B. Raaka

发表

Evaluation of gene expression measurements from commercial microarray platforms.

R. Lempicki, Paul K Tan, T. Downey, 2003, Nucleic acids research.

Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening.

Stefano Costanzi, Susanne Neumann, Irina G Tikhonova, 2008, Journal of medicinal chemistry.

Evidence for cooperative signal triggering at the extracellular loops of the TSH receptor

R. Paschke, B. Raaka, G. Krause, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition

B. Raaka, H. Samuels, Xinyu Zhao, 2002, Oncogene.

Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets

Alan R. Kimmel, B. Raaka, A. Kimmel, 2012, Journal of Cell Science.

TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors.

B M Raaka, H H Samuels, B. Raaka, 1998, Molecular endocrinology.

The conserved ninth C-terminal heptad in thyroid hormone and retinoic acid receptors mediates diverse responses by affecting heterodimer but not homodimer formation

B. Raaka, H. Samuels, E. Helmer, 1993, Molecular and cellular biology.

Half-site spacing and orientation determines whether thyroid hormone and retinoic acid receptors and related factors bind to DNA response elements as monomers, homodimers, or heterodimers.

B. Raaka, H. Samuels, B. M. Forman, 1992, Molecular endocrinology.

Endocrine precursor cells from mouse islets are not generated by epithelial-to-mesenchymal transition of mature beta cells

B. Raaka, E. Geras-Raaka, M. Gershengorn, 2007, Molecular and Cellular Endocrinology.

Are Better Islet Cell Precursors Generated by Epithelial-to-Mesenchymal Transition?

B. Raaka, A. Hardikar, E. Geras-Raaka, 2005, Cell cycle.

Thyroid hormone receptors and action: the 5'-flanking region of the rat growth hormone gene can mediate regulated gene expression.

B. Raaka, H. Samuels, H. Sahnoun, 1989, Endocrine research.

High Levels of Thyrotropin-Releasing Hormone Receptors Activate Programmed Cell Death in Human Pancreatic Precursors

B. Raaka, E. Geras-Raaka, M. Gershengorn, 2009, Pancreas.

Human Islet‐Derived Precursor Cells Are Mesenchymal Stromal Cells That Differentiate and Mature to Hormone‐Expressing Cells In Vivo

B. Raaka, B. Marcus-Samuels, E. Geras-Raaka, 2007, Stem cells.

The glucocorticoid antagonist 17 alpha-methyltestosterone binds to the 10 S glucocorticoid receptor and blocks agonist-mediated dissociation of the 10 S oligomer to the 4 S deoxyribonucleic acid-binding subunit.

B. Raaka, H. Samuels, M. Finnerty, 1989, Molecular endocrinology.

Effects of molybdate on steroid receptors in intact GH1 cells. Evidence for dissociation of an intracellular 10 S receptor oligomer prior to nuclear accumulation.

B. Raaka, H. Samuels, M. Finnerty, 1985, The Journal of biological chemistry.

The glucocorticoid receptor in GH1 cells. Evidence from dense amino acid labeling and whole cell studies for an equilibrium model explaining the influence of hormone on the intracellular distribution of receptor.

B. Raaka, H. Samuels, 1983, The Journal of biological chemistry.

CHAPTER 4 – Hormonal Regulation of Growth Hormone Synthesis in Cell Cultures: Role of Thyroid and Glucocorticoid Hormone Receptors

B. Raaka, H. Samuels, L. Shapiro, 1983 .

Epithelial-to-Mesenchymal Transition Generates Proliferative Human Islet Precursor Cells

B. Raaka, A. Hardikar, B. Marcus-Samuels, 2004, Science.

Constitutively active thyrotropin and thyrotropin-releasing hormone receptors and their inverse agonists.

B. Raaka, M. Gershengorn, S. Neumann, 2010, Methods in enzymology.

Hormone-dependent and -independent transcriptional activation by thyroid hormone receptors are mediated by different mechanisms.

B. Raaka, H. Samuels, E. Helmer, 1996, Endocrinology.

Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor

B. Raaka, M. Gershengorn, N. Thirunarayanan, 2012, Front. Endocrin..

The ligand-binding domains of the thyroid hormone/retinoid receptor gene subfamily function in vivo to mediate heterodimerization, gene silencing, and transactivation

B M Raaka, H H Samuels, B. Raaka, 1995, Molecular and cellular biology.

Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition.

B. Raaka, M. Gershengorn, I. Tikhonova, 2007, Journal of medicinal chemistry.

A sequence in the rat Pit-1 gene promoter confers synergistic activation by glucocorticoids and protein kinase-C.

B M Raaka, H H Samuels, B. Raaka, 1994, Molecular endocrinology.

In silico discovery of novel Retinoic Acid Receptor agonist structures

Ruben Abagyan, Matthieu Schapira, R. Abagyan, 2001, BMC Structural Biology.

Nonsecreted Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) Can Induce Apoptosis in Human Prostate Cancer Cells by IGF-independent Mechanisms without Being Concentrated in the Nucleus*

B. Raaka, M. Wiench, N. Bhattacharyya, 2006, Journal of Biological Chemistry.

Erythropoietin Signaling: A Novel Regulator of White Adipose Tissue Inflammation During Diet-Induced Obesity

B. Raaka, O. Gavrilova, C. Noguchi, 2014, Diabetes.

Insulin but Not Glucagon Gene is Silenced in Human Pancreas‐Derived Mesenchymal Stem Cells

B. Raaka, E. Geras-Raaka, M. Gershengorn, 2009, Stem cells.

β‐catenin signalling in mesenchymal islet‐derived precursor cells

B. Raaka, E. Geras-Raaka, M. Gershengorn, 2008, Cell proliferation.

Inhibition of fatty acid oxidation by 2-bromooctanoate. Evidence for the enzymatic formation of 2-bromo-3-ketooctanoyl coenzyme A and the inhibition of 3-ketothiolase.

B. Raaka, J. Lowenstein, 1979, The Journal of biological chemistry.

Inhibition of fatty acid oxidation by 2-bromooctanoate. Including effects of bromooctanoate on ketogenesis and gluconeogenesis.

B. Raaka, J. Lowenstein, 1979, The Journal of biological chemistry.

Regulation of thyroid hormone nuclear receptor levels in GH1 cells by 3,5,3'-triiodo-L-thyronine. Use of dense amino acid labeling to determine the influence of hormone on the receptor half-life and the rate of appearance of newly synthesized receptor.

B. Raaka, H. Samuels, 1981, The Journal of biological chemistry.

A 10-amino-acid sequence in the N-terminal A/B domain of thyroid hormone receptor alpha is essential for transcriptional activation and interaction with the general transcription factor TFIIB

B. Raaka, H. Samuels, V. Desai-Yajnik, 1995, Molecular and cellular biology.

Carboxyl Tail Cysteine Mutants of the Thyrotropin-Releasing Hormone Receptor Type 1 Exhibit Constitutive Signaling: Role of Palmitoylation

B. Raaka, Y. Oron, D. Du, 2005, Molecular Pharmacology.

Thyrotropin-Releasing Hormone Receptor Type 1 (TRH-R1), not TRH-R2, Primarily Mediates Taltirelin Actions in the CNS of Mice

B. Raaka, M. Gershengorn, N. Thirunarayanan, 2013, Neuropsychopharmacology.

TRH Receptor Type 2 Deficient Mice are Euthyroid and Exhibit Increased Depression and Reduced Anxiety Phenotypes

B. Raaka, M. Toth, M. Gershengorn, 2008, Neuropsychopharmacology.

Understanding the structural and functional differences between mouse thyrotropin‐releasing hormone receptors 1 and 2

B. Raaka, F. Deflorian, M. Gershengorn, 2008, Proteins.

The Human Insulin Gene Displays Transcriptionally Active Epigenetic Marks in Islet‐Derived Mesenchymal Precursor Cells in the Absence of Insulin Expression

B. Raaka, G. Felsenfeld, M. Gershengorn, 2007, Stem cells.

The herpes simplex virus thymidine kinase gene promoter contains a novel thyroid hormone response element.

B. Raaka, H. Samuels, H. Park, 1993, Molecular endocrinology.

Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking

Ruben Abagyan, Maxim Totrov, Matthieu Schapira, 2003, Proceedings of the National Academy of Sciences of the United States of America.

4 – Thyroid Hormone Receptor Synthesis and Degradation and Interaction with Chromatin Components

B. Raaka, H. Samuels, F. Stanley, 1983 .

Organization of the thyroid hormone receptor in chromatin.

B. Raaka, H. Samuels, F. Stanley, 1982, Recent progress in hormone research.

A drug-like antagonist inhibits thyrotropin receptor-mediated stimulation of cAMP production in Graves' orbital fibroblasts.

B. Raaka, E. Geras-Raaka, M. Gershengorn, 2012, Thyroid : official journal of the American Thyroid Association.

Human TSH receptor ligands as pharmacological probes with potential clinical application

B. Raaka, M. Gershengorn, S. Neumann, 2009, Expert review of endocrinology & metabolism.

Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice

B. Raaka, Noel Southall, C. Austin, 2009, Proceedings of the National Academy of Sciences.

A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism.

B. Raaka, G. Krause, M. Gershengorn, 2008, Endocrinology.

Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns.

Gerd Krause, Stefano Costanzi, Susanne Neumann, 2006, Journal of medicinal chemistry.

Human pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates

B. Raaka, A. Hardikar, B. Marcus-Samuels, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Functional evidence for ligand-dependent dissociation of thyroid hormone and retinoic acid receptors from an inhibitory cellular factor

B. Raaka, H. Samuels, J. Qi, 1994, Molecular and cellular biology.

Rational discovery of novel nuclear hormone receptor antagonists

R Abagyan, M Schapira, B M Raaka, 2000, Proc. Natl. Acad. Sci. USA.

Role of the conserved C-terminal region of thyroid hormone receptor-α in ligand-dependent transcriptional activation

B. Raaka, H. Samuels, S. Selmi‐Ruby, 1998, Molecular and Cellular Endocrinology.

TITLE : Toward a New Chemotherapy for Breast Cancer : Structural and Functional Mechanism of the Retinoid Receptors Addressed by a Novel Computer Approach

B. Raaka, M. Schapira, 2022 .

interaction with the general transcription factor is essential for transcriptional activation and A / B domain of thyroid hormone receptor alpha A 10-amino-acid sequence in the N-terminal

B. Raaka, H. Samuels, V. Desai-Yajnik, 1995 .

A Low Molecular Weight Agonist Signals by Binding to the Transmembrane Domain of Thyroid-stimulating Hormone Receptor (TSHR) and Luteinizing Hormone/Chorionic Gonadotropin Receptor (LHCGR)*

R. Paschke, B. Raaka, G. Krause, 2006, Journal of Biological Chemistry.

[42] 2-Bromooctanoate

B. Raaka, J. Lowenstein, 1981 .

Identification of Residues Important for Agonist Recognition and Activation in GPR40*

Stefano Costanzi, Susanne Neumann, Irina G Tikhonova, 2007, Journal of Biological Chemistry.

A Novel Multifunctional Motif in the Amino-terminal A/B Domain of T3Rα Modulates DNA Binding and Receptor Dimerization*

B. Raaka, H. Samuels, E. Hadzic, 1998, The Journal of Biological Chemistry.

Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice

B. Raaka, Noel Southall, C. Austin, 2009, Proceedings of the National Academy of Sciences.

High Levels of Thyrotropin-Releasing Hormone Receptors Activate Programmed Cell Death in Human Pancreatic Precursors

B. Raaka, M. Gershengorn, Christopher M Mulla, 2009, Pancreas.