M. Struthers

发表

Design of a Monomeric 23-Residue Polypeptide with Defined Tertiary Structure

M. Struthers, R. P. Cheng, B. Imperiali, 1996, Science.

Design and NMR analyses of compact, independently folded BBA motifs.

M. Struthers, B. Imperiali, J. Ottesen, 1998, Folding & design.

Potent heteroarylpiperidine and carboxyphenylpiperidine 1-alkyl-cyclopentane carboxamide CCR2 antagonists.

M. Struthers, J. Demartino, S. Mills, 2008, Bioorganic & medicinal chemistry letters.

Persistent IL-2 Receptor Signaling by IL-2/CD25 Fusion Protein Controls Diabetes in NOD Mice by Multiple Mechanisms

M. Struthers, Liping Yu, T. Malek, 2020, Diabetes.

IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells

A. Yamniuk, M. Struthers, T. Malek, 2018, The Journal of Immunology.

THE INFLUENCE OF IRON-DEXTRAN COMPLEX ON THE STRAIN L FIBROBLAST

M. Struthers, B. Danes, 1961, The Journal of biophysical and biochemical cytology.

Tertiary interactions between the fifth and sixth transmembrane segments of rhodopsin.

M. Struthers, D. Oprian, H. Yu, 1999, Biochemistry.

G protein-coupled receptor activation: analysis of a highly constrained, "straitjacketed" rhodopsin.

M. Struthers, D. Oprian, H. Yu, 2000, Biochemistry.

Heterocyclic acetamide and benzamide derivatives as potent and selective beta3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles.

M. Struthers, R. Berger, S. Feighner, 2010, Bioorganic & medicinal chemistry letters.

Diaryl substituted pyrazoles as potent CCR2 receptor antagonists.

M. Struthers, J. Demartino, A. Pinkerton, 2007, Bioorganic & medicinal chemistry letters.

Expression and characterization of the chemokine receptor CCR2B from rhesus monkey.

M. Struthers, W. Hanlon, J. Demartino, 2003, Biochemical pharmacology.

Leukotriene B4 Strongly Increases Monocyte Chemoattractant Protein-1 in Human Monocytes

Jilly F. Evans, M. Struthers, F. Ujjainwalla, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Rhesus monkey model for concurrent analyses of in vivo selectivity, pharmacokinetics and pharmacodynamics of aldosterone synthase inhibitors.

M. Struthers, X. Tong, T. Cai, 2015, Journal of pharmacological and toxicological methods.

Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist.

M. Struthers, M. Forrest, J. Demartino, 2010, Journal of immunological methods.

Synthesis and immunological activities of novel agonists of toll-like receptor 9.

M. Struthers, Hao Wang, Dong Yu, 2010, Cellular immunology.

Investigation of piperazine benzamides as human β3 adrenergic receptor agonists for the treatment of overactive bladder.

M. Struthers, R. Berger, C. Moyes, 2017, Bioorganic & medicinal chemistry letters.

Design, synthesis, and evaluation of conformationally restricted acetanilides as potent and selective β3 adrenergic receptor agonists for the treatment of overactive bladder.

M. Struthers, R. Berger, C. Moyes, 2014, Journal of medicinal chemistry.

CCR2 antagonists.

M. Struthers, A. Pasternak, 2010, Current topics in medicinal chemistry.

Design, synthesis, and structure-activity relationship of novel CCR2 antagonists.

M. Struthers, M. Maccoss, J. Demartino, 2009, Bioorganic & medicinal chemistry letters.

Dual targeting of CCR2 and CX3CR1 in an arterial injury model of vascular inflammation

M. Jerath, M. Struthers, P. Liu, 2010, Thrombosis journal.

Conformational studies of 3-amino-1-alkyl-cyclopentane carboxamide CCR2 antagonists leading to new spirocyclic antagonists.

M. Struthers, J. Demartino, G. Butora, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and immunological activities of novel Toll-like receptor 7 and 8 agonists.

M. Struthers, S. Agrawal, D. Casimiro, 2011, Cellular immunology.

Targeting native and apo-sGC

M. Struthers, Sophie Roy, C. Sinz, 2013, BMC Pharmacology and Toxicology.

Mapping tertiary contacts between amino acid residues within rhodopsin.

M. Struthers, D. Oprian, 2000, Methods in enzymology.

Mouse IL-2/CD25 Fusion Protein Induces Regulatory T Cell Expansion and Immune Suppression in Preclinical Models of Systemic Lupus Erythematosus

M. Struthers, P. Mangan, C. Tovar, 2021, The Journal of Immunology.

Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.

M. Struthers, R. Berger, C. Moyes, 2016, Journal of medicinal chemistry.

Discovery of a Potent and Orally Bioavailable CCR2 and CCR5 Dual Antagonist

M. Struthers, J. Demartino, R. Kilburn, 2010 .

Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β3 adrenergic receptor agonists.

M. Struthers, S. Galloway, S. Feighner, 2011, Bioorganic & medicinal chemistry letters.

Discovery of benzamides as potent human β3 adrenergic receptor agonists.

M. Struthers, A. Weber, G. Salituro, 2016, Bioorganic & medicinal chemistry letters.

Pharmacological Characterization of a Novel Beta 3 Adrenergic Agonist, Vibegron: Evaluation of Antimuscarinic Receptor Selectivity for Combination Therapy for Overactive Bladder

M. Struthers, J. Demartino, J. Woods, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Dual Inhibition of Interleukin-23 and Interleukin-17 Offers Superior Efficacy in Mouse Models of Autoimmunity

Noah T. Ditto, M. Struthers, K. McIntyre, 2015, The Journal of Pharmacology and Experimental Therapeutics.

A novel function of CXCL10 in mediating monocyte production of proinflammatory cytokines

M. Struthers, T. Olah, L. Salter-Cid, 2017, Journal of leukocyte biology.

Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.

M. Struthers, D. Macneil, D. Cully, 2017, Bioorganic & medicinal chemistry letters.

Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Michael E. Lassman, M. Struthers, Qingzhong Hu, 2015, ACS medicinal chemistry letters.

Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Michael E. Lassman, Jeffrey T. Kuethe, M. Struthers, 2015, ACS medicinal chemistry letters.

Economy in Protein Design: Evolution of a Metal-Independent ββα Motif Based on the Zinc Finger Domains

Barbara Imperiali, M. Struthers, R. P. Cheng, 1996 .

Structural and Functional Characterization of a Constrained Asx-Turn Motif

M. Struthers, B. Imperiali, J. Spencer, 1994 .

Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension.

M. Struthers, D. Macneil, D. Cully, 2017, ACS medicinal chemistry letters.

Persistent IL-2R signaling by IL-2/CD25 fusion protein controls diabetes in NOD mice by multiple mechanisms

M. Struthers, Liping Yu, T. Malek, 2020 .

Nonisotopic DNA detection system employing elastase and fluorogenic rhodamine substrate.

M. Struthers, W. Mangel, K. Pierson, 1993, Analytical chemistry.