B. Orser

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Evaluation of a preoperative checklist and team briefing among surgeons, nurses, and anesthesiologists to reduce failures in communication.

R. Reznick, G. Regehr, L. Lingard, 2008, Archives of surgery.

Communication failures in the operating room: an observational classification of recurrent types and effects

R. Reznick, G. Regehr, L. Lingard, 2004, Quality and Safety in Health Care.

Inhaled Anesthetics and Immobility: Mechanisms, Mysteries, and Minimum Alveolar Anesthetic Concentration

B. Orser, B. Vissel, E. Eger, 2003, Anesthesia and analgesia.

Global PRoMiSe (Perioperative Recommendations for Medication Safety): protocol for a mixed-methods study

Karen C. Nanji, Sofia D. Shaikh, A. Merry, 2020, BMJ Open.

Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors

B. Orser, J. Macdonald, J. Lambert, 2004 .

Anesthetic neurotoxicity--clinical implications of animal models.

B. Orser, B. Rappaport, S. Suresh, 2015, The New England journal of medicine.

Inhibition by propofol (2,6 di‐isopropylphenol) of the N‐methyl‐D‐aspartate subtype of glutamate receptor in cultured hippocampal neurones

B. Orser, L. Wang, J. Macdonald, 1995, British journal of pharmacology.

Multiple Mechanisms of Ketamine Blockade of N‐methyl‐D‐aspartate Receptors

Peter S. Pennefather, Beverley A. Orser, John F. MacDonald, 1997, Anesthesiology.

Emerging molecular mechanisms of general anesthetic action.

B. Orser, J. Trudell, M. Akabas, 2005, Trends in pharmacological sciences.

Getting teams to talk: development and pilot implementation of a checklist to promote interprofessional communication in the OR

G R Baker, R Reznick, R. Reznick, 2005, Quality and Safety in Health Care.

Sleep and Anesthesia: Neural Correlates in Theory and Experiment

Beverley A. Orser, B. Orser, Dian-shi Wang, 2012, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

Silence, power and communication in the operating room

Lorelei Lingard, Sherry Espin, Sarah Whyte, 2009, Journal of Advanced Nursing.

Extrasynaptic GABAA receptors are critical targets for sedative-hypnotic drugs.

B. Orser, Beverley A Orser, 2006, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

Programming errors contribute to death from patient-controlled analgesia: case report and estimate of probability

Kim J. Vicente, Beverley A. Orser, K. J. Vicente, 2003, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Intubation of SARS patients: infection and perspectives of healthcare workers

R. Byrick, B. Orser, B. Orser, 2006, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations

B. Orser, J. Macdonald, Y. Mori, 2007, Proceedings of the National Academy of Sciences.

The sedative but not the memory-blocking properties of ethanol are modulated by α5-subunit-containing γ-aminobutyric acid type A receptors

Loren J. Martin, B. Orser, R. Bonin, 2011, Behavioural Brain Research.

Desensitization Receptor A Networks With Anesthetics: Role of GABA Disruption of Coherent Oscillations in Inhibitory

F. Skinner, T. Netoff, B. Orser, 2015 .

Inhibiting α5 Subunit-Containing γ-Aminobutyric Acid Type A Receptors Attenuates Cognitive Deficits After Traumatic Brain Injury.

B. Orser, A. Baker, Dian-shi Wang, 2019, Critical care medicine.

Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery.

M. Kelz, R. Eckenhoff, B. Orser, 2019, Trends in pharmacological sciences.

A Nonselective Cation Channel in Adult Alveolar Epithelial Cells

B. Orser, J. Edelson, 1994 .

Repeated intermittent alcohol exposure during the third trimester-equivalent increases expression of the GABAA receptor δ subunit in cerebellar granule neurons and delays motor development in rats

B. Orser, C. Valenzuela, R. A. Morton, 2014, Neuropharmacology.

In Reply.

B. Orser, R. Horner, Dian-shi Wang, 2016, Anesthesiology.

Drug safety in Canada: 2 steps forward, 1 step back

B. Orser, S. Hyland, Claire Dionee, 2006, Canadian Medical Association Journal.

New opportunities for anesthesia research in Canada

B. Orser, Donald R. Miller, 2002, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

CELL-SPECIFIC GENE EXPRESSION PATTERN OF α5-SUBUNIT CONTAINING γ-AMINOBUTYRIC ACID SUBTYPE A RECEPTORS IN HUMAN AND MOUSE PREFRONTAL CORTEX

B. Orser, M. Banasr, A. Salahpour, 2018 .

Cognitive decline among older adults: A hidden preexisting condition and its role in â•Ÿbrainâ•’atâ•’riskâ•Ž surgical patients

B. Orser, S. Avramescu, Stephen Choi, 2021 .

Insulin Decreases Isoflurane Minimum Alveolar Anesthetic Concentration in Rats Independently of an Effect on the Spinal Cord

B. Orser, E. Eger, M. Laster, 2004, Anesthesia and analgesia.

Non‐steroidal anti‐inflammatory drugs increase insulin release from beta cells by inhibiting ATP‐sensitive potassium channels

B. Orser, W. Ju, M. Wheeler, 2007, British journal of pharmacology.

An anti-coagulation agent Futhan preferentially targets GABA(A) receptors in lungepithelia: implication in treating asthma.

B. Orser, J. Macdonald, Wei-yang Lu, 2011, International journal of physiology, pathophysiology and pharmacology.

Desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors facilitates use-dependent inhibition by pentobarbital.

B. Orser, J. Macdonald, M. F. Jackson, 2003, Molecular pharmacology.

Inhibition of a tonic inhibitory conductance in mouse hippocampal neurons by negative allosteric modulators of α5GABAA receptors: implications for treating cognitive deficits Running Title: Comparing the effect of α5GABAA receptor NAMs

B. Orser, O. Popa, J. Atack, 2021 .

Inhibition of a tonic inhibitory conductance in mouse hippocampal neurones by negative allosteric modulators of α5 subunit-containing γ-aminobutyric acid type A receptors: implications for treating cognitive deficits.

B. Orser, J. Atack, Dian-shi Wang, 2020, British journal of anaesthesia.

Musings from an Unlikely Clinician-Scientist: 2018 American Society of Anesthesiologists Excellence in Research Award.

B. Orser, 2019, Anesthesiology.

Anesthetic sensitivity is reduced in hippocampal pyramidal neurons from GABAA receptor α5 subunit null mutant mice

B. Orser, J. Macdonald, Valerie B Caraiscos, 2005 .

A GABAergic system in airway epithelium is essential for mucus overproduction in asthma

P. O'Byrne, B. Orser, Mingyao Liu, 2007, Nature Medicine.

The modulation of TRPM7 currents by nafamostat mesilate depends directly upon extracellular concentrations of divalent cations

B. Orser, J. Macdonald, Y. Mori, 2010, Molecular Brain.

Platelet Glycoprotein IIb/IIIa Inhibitors: Overview and Implications for the Anesthesiologist

B. Orser, M. Madan, R. Chun, 2002, Anesthesia and analgesia.

Sedating ventilated COVID-19 patients with inhalational anesthetic drugs

B. Orser, Dian-shi Wang, Wei-yang Lu, 2020, EBioMedicine.

Isoflurane Regulates Atypical Type-A &ggr;-Aminobutyric Acid Receptors in Alveolar Type II Epithelial Cells

B. Orser, J. Macdonald, J. Hogg, 2013, Anesthesiology.

“Seizing” the opportunity to understand antifibrinolytic drugs

B. Orser, C. Mazer, Irene Lecker, 2011, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

The Prevention of Chronic Postsurgical Pain Using Gabapentin and Pregabalin: A Combined Systematic Review and Meta-Analysis

B. Orser, Marina F Englesakis, R. Bonin, 2012, Anesthesia and analgesia.

Preventing delirium: beyond dexmedetomidine

B. Orser, Dian-shi Wang, S. Avramescu, 2017, The Lancet.

Anesthesiology in the 21st century: our science is our destiny

B. Orser, 2018, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

Propranolol protection from bupivacaine toxicity

B. Orser, J. Macdonald, 1992, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

SmartTots Update Regarding Anesthetic Neurotoxicity in the Developing Brain.

B. Orser, S. Suresh, A. Evers, 2018, Anesthesia and analgesia.

Mechanisms of anesthesia: past, present, and a glimpse into the future

B. Orser, K. Miller, S. Roth, 2011, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Gabapentin increases expression of δ subunit-containing GABAA receptors

B. Orser, R. Bonin, G. Baker, 2019, EBioMedicine.

In Memoriam: Brian Kavanagh, 1962 to 2019.

B. Orser, L. Brochard, 2019, Anesthesiology.

Propofol and thiopental anesthesia: a comparison of the incidence of dreams and perioperative mood alterations.

B. Orser, L. Ferris, D. Oxorn, 1994 .

Propofol, seizure and antidepressants

B. Orser, D. Oxorn, 1994, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Ketamine Increases the Function of &ggr;-Aminobutyric Acid Type A Receptors in Hippocampal and Cortical Neurons

B. Orser, Dian-shi Wang, Antonello Penna, 2017, Anesthesiology.

The Impact of Inflammation and General Anesthesia on Memory and Executive Function in Mice

B. Orser, Dian-shi Wang, R. Syed, 2022, Anesthesia and analgesia.

No community left behind: advancing rural anesthesia, surgery, and obstetric care in Canada

B. Orser, C. Wilson, Jason A. McVicar, 2022, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

Tyrosine kinases enhance the function of glycine receptors in rat hippocampal neurons and human α1β glycine receptors

B. Orser, S. Mihic, J. Macdonald, 2002 .

Sevoflurane and lipopolysaccharide-induced inflammation differentially affect γ-aminobutyric acid type A receptor-mediated tonic inhibition in the hippocampus of male mice.

B. Orser, Dian-shi Wang, S. Khodaei, 2022, British journal of anaesthesia.

Isobolographic Analysis of the Interactions between Midazolam and Propofol at GABAA Receptors in Embryonic Mouse Neurons

B. Orser, J. Macdonald, L. McAdam, 1998, Anesthesiology.

High Concentrations of Tranexamic Acid Inhibit Ionotropic Glutamate Receptors

B. Orser, C. Mazer, Dian-shi Wang, 2017, Anesthesiology.

Tranexamic acid–associated seizures: Causes and treatment

B. Orser, C. Mazer, Dian-shi Wang, 2015, Annals of neurology.

Etomidate Targets α5 γ-Aminobutyric Acid Subtype A Receptors to Regulate Synaptic Plasticity and Memory Blockade

Loren J. Martin, B. Orser, Gabriel Oh, 2009, Anesthesiology.

Tranexamic acid concentrations associated with human seizures inhibit glycine receptors.

B. Orser, C. Mazer, A. Romaschin, 2012, The Journal of clinical investigation.

Magnesium deficiency increases ketamine sensitivity in rats

B. Orser, A. Gelb, D. Smith, 1997, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Laboratory Investigation Magnesium deficiency increases ketamine sensitivity in rats

B. Orser, A. Gelb, D. Smith, 1997 .

Altered expression of δGABAA receptors in health and disease

B. Orser, Dian-shi Wang, P. Whissell, 2015, Neuropharmacology.

Memory Deficits Induced by Inflammation Are Regulated by α5-Subunit-Containing GABAA Receptors

Wei-Yang Lu, Beverley A. Orser, Paul A. Davies, 2012, Cell reports.

Blockade of AMPA Receptors and Volatile Anesthetics: Reduced Anesthetic Requirements in GluR2 Null Mutant Mice for Loss of the Righting Reflex and Antinociception but Not Minimum Alveolar Concentration

B. Orser, E. Eger, D. Gong, 2001, Anesthesiology.

Inhibition of learning and memory by general anesthetics

B. Orser, Dian-shi Wang, Beverley A Orser, 2011, Canadian Journal of Anaesthesia-journal Canadien D Anesthesie.

Selective Enhancement of Tonic GABAergic Inhibition in Murine Hippocampal Neurons by Low Concentrations of the Volatile Anesthetic Isoflurane

B. Orser, J. Macdonald, T. Rosahl, 2004, The Journal of Neuroscience.

Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons.

B. Orser, J. Macdonald, P. Pennefather, 2001, Molecular pharmacology.

α5GABAA Receptor Activity Sets the Threshold for Long-Term Potentiation and Constrains Hippocampus-Dependent Memory

Loren J. Martin, J. Roder, B. Orser, 2010, Journal of Neuroscience.

Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors.

B. Orser, J. Macdonald, J. Lambert, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Design and screening of ASIC inhibitors based on aromatic diamidines for combating neurological disorders.

B. Orser, J. Macdonald, Xuanmao Chen, 2010, European journal of pharmacology.

Plasticity of synaptic glun receptors is required for the Src‐dependent induction of long‐term potentiation at CA3‐CA1 synapses

B. Orser, J. Macdonald, M. Salter, 2011, Hippocampus.

Platelet-derived Growth Factor Receptor-induced Feed-forward Inhibition of Excitatory Transmission between Hippocampal Pyramidal Neurons*

B. Orser, C. Valenzuela, J. Macdonald, 1999, The Journal of Biological Chemistry.

Modulation of NMDA receptors.

B. Orser, J. Macdonald, R. Raouf, 1998, Progress in brain research.

Blockade of glutamate receptors and barbiturate anesthesia: increased sensitivity to pentobarbital-induced anesthesia despite reduced inhibition of AMPA receptors in GluR2 null mutant mice.

J. Roder, B. Orser, J. Sonner, 1999, Anesthesiology.

The Influence of Glutamate Receptor 2 Expression on Excitotoxicity in GluR2 Null Mutant Mice

J. Roder, B. Orser, M. Tymianski, 2001, The Journal of Neuroscience.

Cyclic GMP-dependent feedback inhibition of AMPA receptors is independent of PKG

J. Roder, B. Orser, J. Macdonald, 2000, Nature Neuroscience.

G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors

Wei Yang Lu, B. Orser, J. Macdonald, 1999, Nature Neuroscience.

Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A

B. Orser, J. Macdonald, D. Brautigan, 1994, Nature.

Diarylamidines: High potency inhibitors of acid-sensing ion channels

B. Orser, J. Macdonald, Z. Xiong, 2010, Neuropharmacology.

Recommendations for Endotracheal Intubation of COVID-19 Patients

B. Orser, Beverley A Orser, 2020, Anesthesia and analgesia.

GABA promotes β‐cell proliferation, but does not overcome impaired glucose homeostasis associated with diet‐induced obesity

B. Orser, N. Winegarden, F. Dai, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

GABA promotes b -cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity

B. Orser, N. Winegarden, F. Dai, 2019 .

A D2 Class Dopamine Receptor Transactivates a Receptor Tyrosine Kinase to Inhibit NMDA Receptor Transmission

B. Orser, J. Macdonald, H. V. Tol, 2002, Neuron.

Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia

Loren J. Martin, B. Orser, J. Macdonald, 2009, Nature Neuroscience.

Regulation of N-methyl-D-aspartate receptor function by constitutively active protein kinase C.

B. Orser, L. Wang, J. Macdonald, 1998, Molecular pharmacology.

Strains of Inbred Mice Tuning of LTP at Hippocampal Synapses of Specific Differential Maintenance and Frequency-Dependent

Loren J. Martin, K. Harris, R. Chitwood, 2015 .

Protocol for a prospective cohort study of assessing postoperative cognitive changes after total hip and knee arthroplasty in the Greater Toronto area

B. Orser, S. Avramescu, Stephen Choi, 2019, BMJ Open.

Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar.

K. Blomgren, W. Slikker, B. Orser, 2013, British journal of anaesthesia.

An anaesthetic drug error: minimizing the risk

B. Orser, D. Oxorn, 1994, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

The General Anesthetic Propofol Slows Deactivation and Desensitization of GABAA Receptors

B. Orser, J. Macdonald, P. Pennefather, 1999, The Journal of Neuroscience.

Gabapentin does not reduce preoperative anxiety when given prior to total hip arthroplasty.

B. Orser, N. Mitsakakis, J. Katz, 2010, Pain medicine.

The Effects of Midazolam on Propofol-Induced Anesthesia: Propofol Dose Requirements, Mood Profiles, and Perioperative Dreams

L. E. Ferris, B. Orser, D. Oxorn, 1997, Anesthesia and analgesia.

Gabapentin reduces preoperative anxiety and pain catastrophizing in highly anxious patients prior to major surgery: a blinded randomized placebo-controlled trial

B. Orser, N. Mitsakakis, R. Katznelson, 2013, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

Propofol-benzodiazepine interactions: insights from a “bench to bedside” approach

B. Orser, Donald R. Miller, 2001, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Propofol and Thiopental Anesthesia: A Comparison of the Incidence of Dreams and Perioperative Mood Alterations

B. Orser, L. Ferris, D. Oxorn, 1994, Anesthesia and analgesia.

Nitrous oxide as a putative novel dual-mechanism treatment for bipolar depression: Proof-of-concept study design and methodology

B. Orser, B. MacIntosh, B. Goldstein, 2020, Contemporary clinical trials communications.

UPDATE: SNIPPETS OF SCIENCE

B. Orser, 2007 .

Review article: Improving drug safety for patients undergoing anesthesia and surgery

B. Orser, S. Hyland, C. Wilson, 2013, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

Dystonic reaction to propofol attenuated by benztropine (cogentin).

B. Orser, Belinda M Schramm, 2002, Anesthesia and analgesia.

Mechanisms of general anesthesia

B. Orser, J. Macdonald, K. J. Canning, 2002, Current opinion in anaesthesiology.

Perioperative Neurocognitive Disorder: State of the Preclinical Science.

M. Maze, M. Eckenhoff, R. Eckenhoff, 2020, Anesthesiology.

External compression of a nasotracheal tube due to the displaced bony fragments of multiple LeFort fractures.

B. Orser, D. Joo, 2000, Anesthesiology.

Physostigmine, propofol and the GABAA receptor

B. Orser, 1998, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group

Charles H. Brown, M. Maze, M. Eckenhoff, 2018, Anesthesia and analgesia.

Obstetrical epidural anaesthesia in a Canadian outpost hospital

B. Orser, 1988, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Canada needs a national strategy for anesthesia services in rural and remote regions

B. Orser, C. Wilson, 2020, Canadian Medical Association Journal.

Improving anesthesia care and pain medicine in rural Canada: nothing about us without us

B. Orser, C. Wilson, D. Bainbridge, 2021, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

Anesthesiology: Resetting Our Sights on Long-term Outcomes: The 2020 John W. Severinghaus Lecture on Translational Science.

B. Orser, 2021, Anesthesiology.

The authors respond to “Nurse anesthesiologists”

B. Orser, C. Wilson, 2020, Canadian Medical Association Journal.

Improving Access to Safe Anesthetic Care in Rural and Remote Communities in Affluent Countries.

B. Orser, A. Rotstein, C. Wilson, 2019, Anesthesia and analgesia.

Anesthesia research training: preparing for the future of our speciality

B. Orser, S. Avramescu, 2016, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

Canadian Anesthesiologists’ Society 2011 Royal College Lecture: Anesthesiology: A Profession at a Crossroads

B. Orser, 2012, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

Intraoperative awareness: from neurobiology to clinical practice.

G. Mashour, B. Orser, M. Avidan, 2011, Anesthesiology.

Pharmacological enhancement of δ-subunit-containing GABAA receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice

Y. Koninck, B. Orser, R. Bonin, 2011, PAIN.

Lifting the fog around anesthesia.

B. Orser, 2007, Scientific American.

α5 Subunit-containing GABAA receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activation

Loren J. Martin, O. Paulsen, M. Vargas-Caballero, 2010, Neuropharmacology.

Tonically activated GABAA receptors in hippocampal neurons are high-affinity, low-conductance sensors for extracellular GABA.

B. Orser, J. Macdonald, P. Pennefather, 2003, Molecular pharmacology.

Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.

B. Orser, C. Mazer, Dian-shi Wang, 2017, The New England journal of medicine.

Gabapentin Increases a Tonic Inhibitory Conductance in Hippocampal Pyramidal Neurons

B. Orser, R. Bonin, J. Macdonald, 2006, Anesthesiology.

α5GABAA receptor deficiency causes autism‐like behaviors

S. Scherer, B. Orser, E. Sibille, 2016, Annals of clinical and translational neurology.

Modulation of NMDA Receptors by Pituitary Adenylate Cyclase Activating Peptide in CA1 Neurons Requires Gαq, Protein Kinase C, and Activation of Src

J. Roder, B. Orser, J. Macdonald, 2005, The Journal of Neuroscience.

Multiple sites of action of neomycin, Mg2+ and spermine on the NMDA receptors of rat hippocampal CA1 pyramidal neurones

B. Orser, J. Macdonald, Z. Xiong, 1998, The Journal of physiology.

Short-term Memory Impairment after Isoflurane in Mice Is Prevented by the &agr;5 &ggr;-Aminobutyric Acid Type A Receptor Inverse Agonist L-655,708

Loren J. Martin, J. Roder, B. Orser, 2010, Anesthesiology.

Anesthesia and Developing Brains: Unanswered Questions and Proposed Paths Forward

B. Orser, L. Vutskits, D. O. Warner, 2022, Anesthesiology.

Inhibition of &agr;5 &ggr;-Aminobutyric Acid Type A Receptors Restores Recognition Memory After General Anesthesia

B. Orser, Agnieszka A. Zurek, Erica M Bridgwater, 2012, Anesthesia and analgesia.

Cognitive Outcomes after DEXmedetomidine sedation in cardiac surgery: CODEX randomised controlled trial protocol

A. Kiss, B. Orser, F. D’Aragon, 2021, BMJ Open.

Medication safety in anesthetic practice: first do no harm

B. Orser, 2000, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABAA Receptor Positive Allosteric Modulator

B. Orser, E. Sibille, S. Piantadosi, 2016, Front. Pharmacol..

Depth-of-anesthesia monitor and the frequency of intraoperative awareness.

Beverley A. Orser, B. Orser, 2008, The New England journal of medicine.

Hydrogen Peroxide Increases GABAA Receptor-Mediated Tonic Current in Hippocampal Neurons

B. Orser, D. Bowie, Dian-shi Wang, 2014, The Journal of Neuroscience.

Thrombocytopenia and cocaine abuse.

B. Orser, 1991, Anesthesiology.

2020 Severinghaus Lecture on Translational Science: Reply.

B. Orser, 2021, Anesthesiology.

Competence-Based Training and Immersion Virtual Reality: Paradigm-Shifting Advances in Medical Education.

B. Orser, S. Spadafora, 2022, Anesthesia and analgesia.

Co-stimulation of mGluR5 and N-Methyl-D-aspartate Receptors Is Required for Potentiation of Excitatory Synaptic Transmission in Hippocampal Neurons*

J. Roder, B. Orser, J. Macdonald, 2003, Journal of Biological Chemistry.

Positive allosteric modulators of AMPA receptors reduce proton-induced receptor desensitization in rat hippocampal neurons.

J. Reynolds, B. Orser, J. Macdonald, 2001, Journal of neurophysiology.

Medication errors in anesthetic practice: a survey of 687 practitioners

B. Orser, B A Orser, D. Yee, 2001, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Sustained increase in α5GABAA receptor function impairs memory after anesthesia.

B. Orser, Dian-shi Wang, Agnieszka A. Zurek, 2014, The Journal of clinical investigation.

Targeting microglia to mitigate perioperative neurocognitive disorders.

B. Orser, N. Terrando, Dian-shi Wang, 2020, British journal of anaesthesia.

GABAA receptor subtypes underlying general anesthesia

B. Orser, R. Bonin, 2008, Pharmacology Biochemistry and Behavior.

General anaesthetics and their effects on GABA(A) receptor desensitization.

B. Orser, J. Macdonald, S. Roder, 1998, Toxicology letters.

Functional Modifications of Acid-Sensing Ion Channels by Ligand-Gated Chloride Channels

B. Orser, J. Macdonald, P. Whissell, 2011, PloS one.

R. Byrick, B. Orser, 2004, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Evaluation of a preoperative team briefing: a new communication routine results in improved clinical practice

R. Reznick, G. Regehr, L. Lingard, 2011, Quality and Safety in Health Care.

Uptake of a team briefing in the operating theatre: a Burkean dramatistic analysis.

R. Reznick, L. Lingard, B. Orser, 2009, Social science & medicine.

Towards safer interprofessional communication: Constructing a model of “utility” from preoperative team briefings

L. Lingard, B. Orser, D. Doran, 2006, Journal of interprofessional care.

Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases

B. Orser, J. Macdonald, Tadashi Yamamoto, 2012, The EMBO journal.

Cellular / Molecular 5 GABAA Receptors Mediate the Amnestic But Not Sedative-Hypnotic Effects of the General Anesthetic Etomidate

Loren J. Martin, J. Roder, B. Orser, 2006 .

The anesthesia workforce in Canada: a methodology to identify physician anesthesia providers using health administrative data

B. Orser, I. Bourgeault, C. Wilson, 2023, Human Resources for Health.

Thalamic δ-Subunit Containing GABAA Receptors Promote Electrocortical Signatures of Deep Non-REM Sleep But Do Not Mediate the Effects of Etomidate at the Thalamus In Vivo

B. Orser, R. Horner, Lia Mesbah-Oskui, 2014, The Journal of Neuroscience.

Dexmedetomidine Prevents Excessive &ggr;-Aminobutyric Acid Type A Receptor Function after Anesthesia

B. Orser, J. Sivak, R. Bonin, 2018, Anesthesiology.

Distinct properties of murine α5 γ‐aminobutyric acid type a receptors revealed by biochemical fractionation and mass spectroscopy

M. Moran, B. Orser, J. Macdonald, 2009, Journal of neuroscience research.

Ketamine augmentation for major depressive disorder and suicidal ideation: Preliminary experience in an inpatient psychiatry setting.

B. Orser, Linda Mah, A. Levitt, 2018, Journal of affective disorders.

α5GABAA Receptors Mediate Tonic Inhibition in the Spinal Cord Dorsal Horn and Contribute to the Resolution Of Hyperalgesia

Y. de Koninck, B. Orser, R. Bonin, 2017, Journal of neuroscience research.

The physiological properties and therapeutic potential of alpha5-GABAA receptors.

Loren J. Martin, B. Orser, R. Bonin, 2009, Biochemical Society transactions.

Paradoxical effects of interprofessional briefings on OR team performance

Lorelei Lingard, Richard Reznick, Diane Doran, 2008, Cognition, Technology & Work.

Single and repeated exposures to the volatile anesthetic isoflurane do not impair operant performance in aged rats.

B. Orser, M. Paule, J. Chelonis, 2016, Neurotoxicology.

Insulin Increases the Potency of Glycine at Ionotropic Glycine Receptors

B. Orser, R. Bonin, J. Macdonald, 2007, Molecular Pharmacology.

Perioperative Medication Errors: Building Safer Systems.

B. Orser, Michael R. Cohen, D. U, 2016, Anesthesiology.

Hyperpolarization-Activated Current (Ih) Is Reduced in Hippocampal Neurons from Gabra5−/− Mice

B. Orser, D. Bayliss, R. Bonin, 2013, PloS one.

Potentiation of GABAA receptor activity by volatile anaesthetics is reduced by α5GABAA receptor-preferring inverse agonists.

B. Orser, Dian-shi Wang, Irene Lecker, 2013, British journal of anaesthesia.

Inflammation Increases Neuronal Sensitivity to General Anesthetics

B. Orser, R. Horner, Dian-shi Wang, 2016, Anesthesiology.

Medication safety in the operating room: teaming up to improve patient safety.

B. Orser, S. Hyland, S. Lingard, 2008, Healthcare quarterly.

Understanding Anesthesia-Induced Memory Loss

B. Orser, Agnieszka A. Zurek, 2015 .

α5GABAA Receptors Regulate the Intrinsic Excitability of Mouse Hippocampal Pyramidal Neurons

Loren J. Martin, B. Orser, R. Bonin, 2007 .

α5GABAA Receptors Mediate the Amnestic But Not Sedative-Hypnotic Effects of the General Anesthetic Etomidate

Loren J. Martin, J. Roder, B. Orser, 2006, The Journal of Neuroscience.

An open label pilot study of a dexmedetomidine‐remifentanil‐caudal anesthetic for infant lower abdominal/lower extremity surgery: The T REX pilot study

Katherine J. Lee, B. Orser, A. Brambrink, 2018, Paediatric anaesthesia.

Acutely increasing δGABAA receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus

Loren J. Martin, B. Orser, Dian-shi Wang, 2013, Front. Neural Circuits.

Cognitive deficits after general anaesthesia in animal models: a scoping review.

B. Orser, S. Halpern, Dian-shi Wang, 2022, British journal of anaesthesia.

Editorial: Innovative approaches for assessing and improving perioperative neurocognitive disorders

B. Orser, P. Purdon, J. Egaña, 2022, Frontiers in Aging Neuroscience.

Propofol-induced neuroexcitation and receptor desensitization

B. Orser, 1994, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Effect of inhaled anaesthetics on cognitive and psychiatric outcomes in critically ill adults: a systematic review and meta-analysis.

A. Owen, B. Orser, S. Bagshaw, 2023, British journal of anaesthesia.

α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells

B. Orser, D. Bowie, M. Accardi, 2015, The Journal of Neuroscience.

Neurodevelopment after general anaesthesia in infants

B. Orser, J. O’Leary, 2019, The Lancet.

GABAA Receptors in Astrocytes Are Targets for Commonly Used Intravenous and Inhalational General Anesthetic Drugs

B. Orser, Dian-shi Wang, S. Khodaei, 2022, Frontiers in Aging Neuroscience.

In CA1 Pyramidal Neurons of the Hippocampus Protein Kinase C Regulates Calcium-Dependent Inactivation of NMDA Receptors

B. Orser, J. Macdonald, M. F. Jackson, 2000, The Journal of Neuroscience.

Proof‐of‐concept randomized controlled trial of single‐session nitrous oxide treatment for refractory bipolar depression: Focus on cerebrovascular target engagement

B. Orser, R. McIntyre, N. Herrmann, 2022, Bipolar disorders.

Reconciling differences between in vitro and in vivo effects of propofol.

B. Orser, J. Macdonald, 1996, Anesthesiology.

Predictive factors for sleep apnoea in patients on opioids for chronic pain

B. Orser, D. Juurlink, M. Mamdani, 2019, BMJ Open Respiratory Research.

Are epsins a therapeutic target for tumor

B. Orser, M. Akabas, H. Hemmings, 2012 .

Awareness during anesthesia

B. Orser, C. Mazer, A. Baker, 2008, Canadian Medical Association Journal.

Disruption of coherent oscillations in inhibitory networks with anesthetics: role of GABA(A) receptor desensitization.

Frances K Skinner, Pamela M Baker, Pamela M. Baker, 2002, Journal of neurophysiology.

δ-Subunit Containing GABAA Receptors Modulate Respiratory Networks

B. Orser, Haiying Wu, R. Horner, 2017, Scientific Reports.

Rat Hippocampal Neurons Reduce Proton-Induced Receptor Desensitization in Positive Allosteric Modulators of AMPA Receptors

J. Reynolds, B. Orser, G. Thatcher, 2006 .

Reduced expression of α5GABAA receptors elicits autism-like alterations in EEG patterns and sleep-wake behavior.

B. Orser, R. Horner, Antonello Penna, 2017, Neurotoxicology and teratology.

&dgr;GABAA Receptors Are Necessary for Synaptic Plasticity in the Hippocampus: Implications for Memory Behavior

B. Orser, Dian-shi Wang, S. Avramescu, 2016, Anesthesia and analgesia.

Cell-surface biotinylation of GABAA receptors in mouse hippocampal slices after sevoflurane anesthesia

B. Orser, Dian-shi Wang, S. Khodaei, 2023, STAR protocols.

Tyrosine kinases enhance the function of glycine receptors in rat hippocampal neurons and human alpha(1)beta glycine receptors.

B. Orser, S. Mihic, J. Macdonald, 2002, The Journal of physiology.

Modulation of AMPA receptors by a novel organic nitrate.

J. Reynolds, B. Orser, J. Macdonald, 2001, Canadian journal of physiology and pharmacology.

γ‐aminobutyric acid type A receptors that contain the δ subunit promote memory and neurogenesis in the dentate gyrus

B. Orser, J. Wojtowicz, Dian-shi Wang, 2013, Annals of neurology.

Current in Cultured Hippocampal Neurons -Sensing Cation 2+ Effect of Lamotrigine on the Ca

S. Roper, B. Orser, J. Macdonald, 2015 .

Perioperative Neurocognitive Screening Tools for At-Risk Surgical Patients.

B. Orser, Stephen Choi, C. Brenna, 2021, Neurology Clinical Practice.

Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery—2018

Jeffrey N. Browndyke, M. Maze, C. Lyketsos, 2018, Anesthesiology.

Reducing medication errors.

B. Orser, 2000, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

Learning together to safely intubate patients with COVID-19.

B. Orser, 2020, Anesthesia and Analgesia.

Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern

B. Orser, Haibo Zhang, J. Penninger, 2023, iScience.

Alpha5GABAA receptors regulate the intrinsic excitability of mouse hippocampal pyramidal neurons.

Loren J. Martin, B. Orser, R. Bonin, 2007, Journal of Neurophysiology.

Intraoperative awareness: from neurobiology to clinical practice.

G. Mashour, B. Orser, M. Avidan, 2011, Anesthesiology.

Reciprocal and activity-dependent regulation of surface AMPA and NMDA receptors in cultured neurons.

B. Orser, J. Macdonald, M. F. Jackson, 2009, International journal of physiology, pathophysiology and pharmacology.

Cognitive decline among older adults: A hidden preexisting condition and its role in ‘brain‐at‐risk’ surgical patients

B. Orser, S. Avramescu, Stephen Choi, 2021, Brain and behavior.

Before the Next Wave: Reducing Viral Infections Among Health Care Workers Performing Tracheal Intubation.

B. Orser, 2022, Anesthesia and analgesia.

Pregabalin effective for the prevention of chronic postsurgical pain: really? Reply.

B. Orser, Marina F Englesakis, R. Bonin, 2013, Anesthesia and analgesia.

Inhibition of learning and memory by general anesthetics

B. Orser, Dian-shi Wang, 2011, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Reducing medication errors.

B. Orser, 2000, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

Preventing neuraxial administration of tranexamic acid

R. Byrick, B. Orser, S. Hyland, 2023, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

Short-term Memory Impairment after Isoflurane in Mice Is Prevented by the &agr;5 &ggr;-Aminobutyric Acid Type A Receptor Inverse Agonist L-655,708

Loren J. Martin, J. Roder, B. Orser, 2010, Anesthesiology.

Desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors facilitates use-dependent inhibition by pentobarbital.

B. Orser, J. Macdonald, M. F. Jackson, 2003, Molecular pharmacology.

Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery—2018

R. Eckenhoff, D. Knopman, S. DeKosky, 2018, Acta anaesthesiologica Scandinavica.

Reduced excitatory neurotransmission in the hippocampus after inflammation and sevoflurane anaesthesia

B. Orser, Dian-shi Wang, S. Khodaei, 2023, BJA Open.

Pharmacological enhancement of δ-subunit-containing GABAA receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice

Y. Koninck, B. Orser, R. Bonin, 2011, PAIN.

Evaluation of a preoperative team briefing: a new communication routine results in improved clinical practice

R. Reznick, G. Regehr, L. Lingard, 2011, BMJ Quality & Safety.

Multimodal anesthesia and systems neuroscience: the new frontier.

C. Saper, B. Orser, 2008, Anesthesiology.

Distinct Functional and Pharmacological Properties of Tonic and Quantal Inhibitory Postsynaptic Currents Mediated by ␥-aminobutyric Acid a Receptors in Hippocampal Neurons

B. Orser, M. F. Jackson, Guoyun Zhu, 2001 .

Repurposing General Anesthetic Drugs to Treat Depression: A New Frontier for Anesthesiologists in Neuropsychiatric Care.

B. Orser, Benjamin I Goldstein, Connor T. A. Brenna, 2024, Anesthesiology.

Brief Research Report Gabapentin Does Not Reduce Preoperative Anxiety When Given Prior to Total Hip Arthroplasty

B. Orser, N. Mitsakakis, J. Katz, 2010 .

GABAA Receptor Theory of Perioperative Neurocognitive Disorders.

B. Orser, Dian-shi Wang, 2019, Anesthesiology.