D. Gomez

发表

Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.

D. Gomez, D. Alonso, H. Yoshiji, 1997, European journal of cell biology.

Preclinical Development of Novel Rac1-GEF Signaling Inhibitors using a Rational Design Approach in Highly Aggressive Breast Cancer Cell Lines

D. Gomez, D. Alonso, A. Turjanski, 2014, Anti-cancer agents in medicinal chemistry.

Homology Model and Docking-Based Virtual Screening for Ligands of Human Dyskerin as New Inhibitors of Telomerase for Cancer Treatment

Ezequiel I. Juritz, D. Gomez, R. Armando, 2018, International journal of molecular sciences.

angiogenesis, tumour growth and metastases in vasopressin type 2 receptor-expressing breast cancer models

D. Gomez, D. Alonso, E. Podesta, 2015 .

The novel desmopressin analogue [V4Q5]dDAVP inhibits angiogenesis, tumour growth and metastases in vasopressin type 2 receptor-expressing breast cancer models

D. Gomez, D. Alonso, U. Orlando, 2015, International journal of oncology.

Antitumor protection by NGcGM3/VSSP vaccine against transfected B16 mouse melanoma cells overexpressing N-glycolylated gangliosides.

D. Gomez, D. Alonso, V. Segatori, 2012, In vivo.

[Rho GTPases as therapeutic targets in cancer and other human diseases].

D. Gomez, D. Alonso, G. Cardama, 2010, Medicina.

Cancer vaccines: an update with special focus on ganglioside antigens.

D. Gomez, D. Alonso, M. Gabri, 2002, Oncology reports.

Protein universe containing a PUA RNA‐binding domain

D. Gomez, C. Cerrudo, P. Ghiringhelli, 2014, The FEBS journal.

Mechanisms of cellular uptake, intracellular transportation, and degradation of CIGB-300, a Tat-conjugated peptide, in tumor cell lines.

D. Gomez, D. Alonso, S. Perea, 2014, Molecular pharmaceutics.

Addition of vasopressin synthetic analogue [V4Q5]dDAVP to standard chemotherapy enhances tumour growth inhibition and impairs metastatic spread in aggressive breast tumour models

D. Gomez, D. Alonso, J. Garona, 2016, Clinical & Experimental Metastasis.

Structure-activity relationship of 1-desamino-8-D-arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor-expressing cancer cells.

D. Gomez, D. Alonso, F. Albericio, 2014, Molecular medicine reports.

Antiproliferative effect of 1-deamino-8-D-arginine vasopressin analogs on human breast cancer cells.

D. Gomez, D. Alonso, J. Garona, 2011, Future medicinal chemistry.

New drugs are not enough-drug repositioning in oncology: An update

D. Gomez, R. Armando, D. M. Gómez, 2020, International journal of oncology.

Sensitivity of tumor cells towards CIGB‐300 anticancer peptide relies on its nucleolar localization

D. Gomez, D. Alonso, Y. Perera, 2012, Journal of peptide science : an official publication of the European Peptide Society.

A purified GM3 ganglioside conjugated vaccine induces specific, adjuvant-dependent and non-transient antitumour activity against B16 mouse melanoma in vitro and in vivo

D. Gomez, L. E. Fernández, Z. Mazorra, 2001, Melanoma research.

Lovastatin alters cytoskeleton organization and inhibits experimental metastasis of mammary carcinoma cells

D. Gomez, D. Alonso, H. Farina, 2004, Clinical & Experimental Metastasis.

Modulation of urokinase‐type plasminogen activator and metalloproteinase activities in cultured mouse mammary‐carcinoma cells: Enhancement by paclitaxel and inhibition by nocodazole

D. Gomez, D. Alonso, M. Aon, 1999, International journal of cancer.

Role of protein kinase C-dependent signaling pathways in the antiangiogenic properties of nafoxidine.

D. Gomez, D. Alonso, M. D. De Lorenzo, 2004, Anticancer research.

Liver tumors and possible preneoplastic lesions, induced by a food-derived heterocyclic amine in cynomolgus monkeys; a study of histology and cytokeratin expression.

D. Gomez, U. Thorgeirsson, R. Adamson, 2008, Liver.

Dietary heterocyclic amines as potential human carcinogens: experimental data from nonhuman primates.

D. Gomez, U. Thorgeirsson, R. Adamson, 1996, In vivo.

Exogenous incorporation of neugc-rich mucin augments n-glycolyl sialic acid content and promotes malignant phenotype in mouse tumor cell lines

D. Gomez, D. Alonso, L. L. Otero, 2009, Journal of experimental & clinical cancer research : CR.

Effect of flavone acetic acid on endothelial cell proliferation: evidence for antiangiogenic properties.

D. Gomez, U. Thorgeirsson, C. K. Lindsay, 1996, Anticancer research.

Expression of gelatinise/type IV collagenase in tumor necrosis correlates with cell detachment and tumor invasion

D. Gomez, E. Farias, O. Bustuoabad, 1992, Clinical & Experimental Metastasis.

RAC3 more than a nuclear receptor coactivator: a key inhibitor of senescence that is downregulated in aging

D. Gomez, D. Alonso, D. M. Mengual Gómez, 2015, Cell Death and Disease.

Antitumor effects of desmopressin in combination with chemotherapeutic agents in a mouse model of breast cancer.

D. Gomez, D. Alonso, G. Ripoll, 2008, Anticancer research.

Desmopressin inhibits lung and lymph node metastasis in a mouse mammary carcinoma model of surgical manipulation

D. Gomez, D. Alonso, G. Ripoll, 2002, Journal of surgical oncology.

Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer.

D. Gomez, H. Yoshiji, U. Thorgeirsson, 1996, Cancer research.

Nafoxidine modulates the expression of matrix-metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in endothelial cells.

D. Gomez, D. Alonso, M. D. De Lorenzo, 2000, Anticancer research.

Active Specific Immunotherapy of Melanoma with a GM3 Ganglioside-Based Vaccine: A Report on Safety and Immunogenicity

D. Gomez, D. Alonso, L. E. Fernández, 2004, Journal of immunotherapy.

A puri®ed GM3 ganglioside conjugated vaccine induces speci®c, adjuvant-dependent and non- transient antitumour activity against B16 mouse melanoma in vitro and in vivo

D. Gomez, L. E. Fernández, Z. Mazorra, 2001 .

CIGB-300, a synthetic peptide-based drug that targets the CK2 phosphoaceptor domain. Translational and clinical research

D. Gomez, D. Alonso, Y. Perera, 2011, Molecular and Cellular Biochemistry.

Systemic administration of a peptide that impairs the protein kinase (CK2) phosphorylation reduces solid tumor growth in mice

D. Gomez, D. Alonso, Y. Perera, 2008, International journal of cancer.

AZT exerts its antitumoral effect by telomeric and non-telomeric effects in a mammary adenocarcinoma model.

D. Gomez, R. Armando, D. M. Gómez, 2016, Oncology reports.

Telomerase as a Cancer Target. Development of New Molecules

D. Gomez, R. Armando, C. Cerrudo, 2016, Current topics in medicinal chemistry.

AZT as a telomerase inhibitor

D. Gomez, D. Alonso, R. Armando, 2012, Front. Oncol..

Tissue factor as a novel marker for detection of circulating cancer cells

D. Gomez, D. Alonso, L. L. Otero, 2011, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

Alterations in endothelial cell proteinase and inhibitor polarized secretion following treatment with interleukin‐1, phorbol ester, and human melanoma cell conditioned medium

R. Rees, D. Gomez, U. Thorgeirsson, 1996, Journal of cellular biochemistry.

Telomere structure and telomerase in health and disease

D. Gomez, D. Alonso, P. L. Menna, 2012, International journal of oncology.

The copper‐chelating agent, trientine, suppresses tumor development and angiogenesis in the murine hepatocellular carcinoma cells

D. Gomez, H. Yoshiji, S. Kuriyama, 2001, International journal of cancer.

Rational design of PIN1 inhibitors for cancer treatment based on conformational diversity analysis and docking based virtual screening

D. Gomez, P. L. Menna, R. Armando, 2021, Journal of biomolecular structure & dynamics.

Role of Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor in MiceBear ing a Highly Invasive and Metastatic Mammary Carcinoma

D. Gomez, D. Alonso, P. L. Menna, 1999, Pathobiology.

Lectins as tools for the purification of liver endothelial cells.

D. Gomez, U. Thorgeirsson, U P Thorgeirsson, 1998, Methods in molecular medicine.

Enhanced RNA expression of tissue inhibitor of metalloproteinases‐1 (TIMP‐1) in human breast cancer

D. Gomez, H. Yoshiji, U. Thorgeirsson, 1996, International journal of cancer.

Inhibition of mammary tumor cell adhesion, migration, and invasion by the selective synthetic urokinase inhibitor B428.

D. Gomez, D. Alonso, E. D. Bal de Kier Joffé, 1998, Anticancer research.

A phase II dose-escalation trial of perioperative desmopressin (1-desamino-8-d-arginine vasopressin) in breast cancer patients

Ignacio A. Demarco, D. Gomez, D. Alonso, 2015, SpringerPlus.

Insight into the effect of the vasopressin analog desmopressin on lung colonization by mammary carcinoma cells in BALB/c mice.

D. Gomez, D. Alonso, J. Garona, 2014, Anticancer research.

Desmopressin reduces melanoma lung metastasis in transgenic mice overexpressing tissue inhibitor of metalloproteinases-1.

D. Gomez, D. Alonso, H. Yoshiji, 2006, In vivo.

Perioperative desmopressin prolongs survival in surgically treated bitches with mammary gland tumours: a pilot study.

D. Gomez, D. Alonso, G. Ripoll, 2008, Veterinary journal.

Novel insights into the evolution and structural characterization of dyskerin using comprehensive bioinformatics analysis.

D. Gomez, D. M. Mengual Gómez, C. Cerrudo, 2015, Journal of proteome research.

Telomeropathies: Etiology, diagnosis, treatment and follow‐up. Ethical and legal considerations

D. Gomez, R. Armando, D. M. Mengual Gómez, 2019, Clinical genetics.

In vitro activity of a Solanum tuberosum extract against mammary carcinoma cells.

D. Gomez, D. Alonso, P. Lorenzano Menna, 2001, Planta medica.

NGcGM3 Ganglioside: A Privileged Target for Cancer Vaccines

D. Gomez, D. Alonso, L. E. Fernández, 2010, Clinical & developmental immunology.

Ganglioside-based vaccines and anti-idiotype antibodies for active immunotherapy against cancer

D. Gomez, D. Alonso, L. E. Fernández, 2003, Expert review of vaccines.

In vivo selection and characterization of a murine mammary tumor subline with high potential for spontaneous lymph node metastasis

D. Gomez, L. Puricelli, M. Vidal, 1990, Journal of surgical oncology.

Tumor invasion, proteolysis, and angiogenesis

D. Gomez, U. Thorgeirsson, C. K. Lindsay, 2005, Journal of Neuro-Oncology.

Racotumomab: an anti-idiotype vaccine related to N-glycolyl-containing gangliosides – preclinical and clinical data

D. Gomez, D. Alonso, E. Montero, 2012, Front. Oncol..

Immunomagnetic separation as a final purification step of liver endothelial cells

D. Gomez, U. Thorgeirsson, A. Nason, 1993, In Vitro Cellular & Developmental Biology - Animal.

Irreversible telomere shortening by 3'-azido-2',3'-dideoxythymidine (AZT) treatment.

D. Gomez, A. Tejera, O. Olivero, 1998, Biochemical and biophysical research communications.

Preferential incorporation of 3'-azido-2',3'-dideoxythymidine (azt) in telomeric sequences of cho cells.

D. Gomez, O. Olivero, A. Kassim, 1995, International journal of oncology.

Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer.

D. Gomez, D. Alonso, H. Farina, 2006, Oncology reports.

Chronic In Vitro Exposure to 3′-Azido-2′, 3′-Dideoxythymidine Induces Senescence and Apoptosis and Reduces Tumorigenicity of Metastatic Mouse Mammary Tumor Cells

D. Gomez, D. Alonso, A. Tejera, 2004, Breast Cancer Research and Treatment.

Partial characterization of novel serine proteinase inhibitors from human umbilical vein endothelial cells.

D. Gomez, U. Thorgeirsson, C. N. Rao, 1995, Archives of biochemistry and biophysics.

Inhibition of aggressiveness of metastatic mouse mammary carcinoma cells by the beta2-chimaerin GAP domain.

D. Gomez, D. Alonso, M. Kazanietz, 2003, Cancer research.

Preclinical Efficacy and Toxicology Evaluation of RAC1 Inhibitor 1A-116 in Human Glioblastoma Models

D. Gomez, D. Alonso, I. Demarco, 2022, Cancers.

Rho GTPases as therapeutic targets in cancer (Review)

D. Gomez, G. Cardama, N. González, 2017, International journal of oncology.

Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells

D. Gomez, D. Alonso, G. Cardama, 2014, OncoTargets and therapy.

Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics.

D. Gomez, D. Alonso, C. Rolfo, 2018, Critical reviews in oncology/hematology.

Reduction of tumor angiogenesis induced by desmopressin in a breast cancer model

D. Gomez, D. Alonso, J. Garona, 2013, Breast Cancer Research and Treatment.

Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity

D. Gomez, X. Bustelo, G. Cardama, 2020, Frontiers in Cell and Developmental Biology.

Ras oncogene mediated induction of a 92 kDa metalloproteinase; strong correlation with the malignant phenotype.

D. Gomez, U. Thorgeirsson, M. Ballin, 1988, Biochemical and biophysical research communications.

Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype.

D. Gomez, D. Alonso, E. Farias, 1999, European journal of biochemistry.

Effect of atorvastatin in a case of feline multicentric lymphoma - Case report.

D. Gomez, D. Alonso, H. Farina, 2011, Acta veterinaria Hungarica.

Characterization of a New Murine Tumor Variant with Different in Vivo Behavior Selected by Its Adhesive Properties

D. Gomez, L. Puricelli, M. Vidal, 1990, Tumori.

Tissue inhibitor of metalloproteinases‐1 promotes liver fibrosis development in a transgenic mouse model

S. Thorgeirsson, D. Gomez, H. Yoshiji, 2000, Hepatology.

Pharmacological inhibition of Rac1-PAK1 axis restores tamoxifen sensitivity in human resistant breast cancer cells.

D. Gomez, D. Alonso, G. Cardama, 2017, Cellular signalling.

Identification of the 72-kDa (MMP-2) and 92-kDa (MMP-9) gelatinase/type IV collagenase in preparations of laminin and Matrigel.

R. Rees, D. Gomez, U. Thorgeirsson, 1993, BioTechniques.

The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).

D. Gomez, D. Alonso, M. Kazanietz, 1999, Oncology reports.

Telomerase regulation: a key to inhibition? (Review).

D. Gomez, H. Farina, D. L. Gómez, 2013, International journal of oncology.

Correspondence re: S. M. Melana et al., Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by 3'-azido-3'-deoxythymidine. Clin. Cancer Res., 4: 693-696, 1998.

D. Gomez, O. Olivero, 1998, Clinical Cancer Research.

Histopathological findings in a highly invasive mouse mammary carcinoma transfected with human tissue inhibitor of metalloproteinases-1.

D. Gomez, D. Alonso, H. Yoshiji, 1998, Oncology reports.

Enhanced cytostatic activity of statins in mouse mammary carcinoma cells overexpressing β2-chimaerin.

D. Gomez, D. Alonso, G. Cardama, 2009, Molecular medicine reports.

A novel hydrophobized GM3 ganglioside/Neisseria meningitidis outer-membrane-protein complex vaccine induces tumor protection in B16 murine melanoma.

D. Gomez, M. Gabri, M. Guthmann, 1999, International journal of oncology.

Molecular detection of circulating tyrosinase mRNA: optimization in a preclinical xenograft mouse melanoma model and further evaluation in samples from advanced melanoma patients.

D. Gomez, D. Alonso, M. Gabri, 2008, International journal of molecular medicine.

Antimetastatic effect of desmopressin in a mouse mammary tumor model

D. Gomez, D. Alonso, E. Farias, 1999, Breast Cancer Research and Treatment.

Mammary carcinoma cells over‐expressing tissue inhibitor of metalloproteinases‐1show vascular endothelial growth factor expression

D. Gomez, H. Yoshiji, U. Thorgeirsson, 1998 .

Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis

D. Gomez, D. Alonso, M. Gabri, 1998, Breast Cancer Research and Treatment.

CIGB-300, a proapoptotic peptide, inhibits angiogenesis in vitro and in vivo.

D. Gomez, D. Alonso, Y. Perera, 2011, Experimental cell research.

Mammary carcinoma cells over-expressing tissue inhibitor of metalloproteinases-1 show enhanced vascular endothelial growth factor expression.

D. Gomez, H. Yoshiji, U. Thorgeirsson, 1998, International journal of cancer.

Expression of metalloproteinases (MMP-1, MMP-2, and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in schistosomal portal fibrosis.

D. Gomez, D. Alonso, M. D. De Lorenzo, 1999, The American journal of tropical medicine and hygiene.

Thrombin treatment of endothelial cells stimulates adhesion of oncogene transformed but not parent rat liver epithelial cells.

D. Gomez, U. Thorgeirsson, A. Nason, 1995, Thrombosis research.

Preclinical Efficacy of [V4Q5]dDAVP, a Second Generation Vasopressin Analog, on Metastatic Spread and Tumor-Associated Angiogenesis in Colorectal Cancer

D. Gomez, D. Alonso, J. Garona, 2018, Cancer research and treatment : official journal of Korean Cancer Association.

Metastasis: Recent Discoveries and Novel Perioperative Treatment Strategies with Particular Interest in the Hemostatic Compound Desmopressin

D. Gomez, D. Alonso, J. Garona, 2011, Current pharmaceutical biotechnology.

Long-term exposure to elevated levels of circulating TIMP-1 but not mammary TIMP-1 suppresses growth of mammary carcinomas in transgenic mice.

S. Thorgeirsson, D. Gomez, H. Yoshiji, 2004, Carcinogenesis.

New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesis

A. F. Castillo, D. Gomez, P. Maloberti, 2020, Cellular and Molecular Life Sciences.

The Functional Interaction between Acyl-CoA Synthetase 4, 5-Lipooxygenase and Cyclooxygenase-2 Controls Tumor Growth: A Novel Therapeutic Target

D. Gomez, D. Alonso, P. Maloberti, 2012, PloS one.

Complete Antitumor Protection by Perioperative Immunization with GM3/VSSP Vaccine in a Preclinical Mouse Melanoma Model

D. Gomez, D. Alonso, G. Ripoll, 2006, Clinical Cancer Research.

CompleteAntitumor Protection by Perioperative Immunizationwith GM 3 / VSSP Vaccine in a Preclinical MouseMelanomaModel

D. Gomez, D. Alonso, G. Ripoll, 2006 .

Role of β2-chimaerin in the behaviour of murine mammary carcinoma cells in response to extracellular matrix components

D. Gomez, D. Alonso, P. L. Menna, 2005 .

Effect of adjuvant perioperative desmopressin in locally advanced canine mammary carcinoma and its relation to histologic grade.

D. Gomez, D. Alonso, G. Hermo, 2011, Journal of the American Animal Hospital Association.

Effects of the synthetic vasopressin analog desmopressin in a mouse model of colon cancer.

D. Gomez, D. Alonso, J. Garona, 2010, Anticancer research.

Altered tumor angiogenesis and metastasis of B16 melanoma in transgenic mice overexpressing tissue inhibitor of metalloproteinases-1.

D. Gomez, D. Alonso, H. Yoshiji, 2003, In vivo.

Antitumor properties of an anti-idiotypic monoclonal antibody in relation to N-glycolyl-containing gangliosides.

D. Gomez, M. Gabri, R. Pérez, 2000, Oncology reports.

Proapoptotic and antiinvasive activity of rac1 small molecule inhibitors on malignant glioma cells

D. Gomez, D. Alonso, G. Cardama, 2014 .

Addition of vasopressin synthetic analogue [V4Q5]dDAVP to standard chemotherapy enhances tumour growth inhibition and impairs metastatic spread in aggressive breast tumour models

D. Gomez, D. Alonso, J. Garona, 2016, Clinical & Experimental Metastasis.

Breast cancer; tumor neovasculature and the effect of tissue inhibitor of metalloproteinases-1 (TIMP-1) on angiogenesis.

D. Gomez, H. Yoshiji, U. Thorgeirsson, 1996, In vivo.

Preclinical evaluation of racotumomab, an anti-idiotype monoclonal antibody to N-glycolyl-containing gangliosides, with or without chemotherapy in a mouse model of non-small cell lung cancer

D. Gomez, D. Alonso, V. Segatori, 2012, Front. Oncol..