H. Hobbs

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A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.

Jonathan C. Cohen, I. Kotowski, A. Pertsemlidis, 2006, American journal of human genetics.

Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels.

Jonathan C. Cohen, S. Grundy, A. Pertsemlidis, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol

Jonathan C. Cohen, A. Pertsemlidis, H. Hobbs, 2004, Science.

Human Fatty Liver Disease: Old Questions and New Insights

Jonathan C. Cohen, H. Hobbs, J. Horton, 2011, Science.

Relation of plasma lipoprotein(a) to infarct artery patency in survivors of myocardial infarction.

E. Boerwinkle, H. Hobbs, L. Hillis, 1993, Circulation.

A Common Allele on Chromosome 9 Associated with Coronary Heart Disease

Jonathan C. Cohen, D. Cox, E. Boerwinkle, 2007, Science.

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease.

Jonathan C. Cohen, E. Boerwinkle, H. Hobbs, 2006, The New England journal of medicine.

Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population.

S. Grundy, H. Hobbs, J. Browning, 2005, American journal of physiology. Endocrinology and metabolism.

Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia.

Jonathan C. Cohen, M. DePristo, E. Banks, 2010, The New England journal of medicine.

Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters.

N. Grishin, H. Hobbs, Liqing Yu, 2000, Science.

Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR

Jonathan C. Cohen, H. Hobbs, Yan Wang, 2012, Journal of Lipid Research.

Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion1[S]

Jonathan C. Cohen, H. Hobbs, J. Gromada, 2015, Journal of Lipid Research.

Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity

Jonathan C. Cohen, S. Grundy, H. Hobbs, 2004, Hepatology.

Sterol Intermediates from Cholesterol Biosynthetic Pathway as Liver X Receptor Ligands*

Jonathan C. Cohen, Helen H. Hobbs, Yuan Zhang, 2006, Journal of Biological Chemistry.

The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health.

Ronald M Peshock, Jennifer M. Staab, Robert W Haley, 2004, The American journal of cardiology.

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9

Alexander Pertsemlidis, Jonathan Cohen, I. Kotowski, 2005, Nature Genetics.

Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β*

H. Hobbs, D. Mangelsdorf, J. Repa, 2002, The Journal of Biological Chemistry.

Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote.

Jonathan C. Cohen, Lisa Kinch, N. Grishin, 2006, American journal of human genetics.

ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion

Jonathan C. Cohen, H. Hobbs, S. Bonner-Weir, 2014, Cell.

Atypical angiopoietin-like protein that regulates ANGPTL3

Jonathan C. Cohen, N. Grishin, E. Boerwinkle, 2012, Proceedings of the National Academy of Sciences.

Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis

Jonathan C. Cohen, H. Hobbs, J. Gromada, 2013, Proceedings of the National Academy of Sciences.

ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance[S]

Jonathan C. Cohen, H. Hobbs, A. Murphy, 2017, Journal of Lipid Research.

ANGPTL8 Blockade With a Monoclonal Antibody Promotes Triglyceride Clearance, Energy Expenditure, and Weight Loss in Mice

Jonathan C. Cohen, H. Hobbs, A. Murphy, 2017, Endocrinology.

Hepatic ANGPTL3 regulates adipose tissue energy homeostasis

Jonathan C. Cohen, H. Hobbs, J. Gromada, 2015, Proceedings of the National Academy of Sciences.

Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.

Jonathan C. Cohen, H. Hobbs, H. Brown, 2012, The Journal of clinical investigation.

Expression and Characterization of a PNPLA3 Protein Isoform (I148M) Associated with Nonalcoholic Fatty Liver Disease*

Jonathan C. Cohen, H. Hobbs, Yongcheng Huang, 2011, The Journal of Biological Chemistry.

Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol.

Jonathan C. Cohen, R. Hammer, H. Hobbs, 2002, The Journal of clinical investigation.

Relative roles of ABCG5/ABCG8 in liver and intestine

Jonathan C. Cohen, H. Hobbs, Matthew A. Mitsche, 2015, Journal of Lipid Research.

Purification and reconstitution of sterol transfer by native mouse ABCG5 and ABCG8.

Jonathan C. Cohen, H. Hobbs, Y. Lei, 2008, Biochemistry.

Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8 Published, JLR Papers in Press, June 1, 2005. DOI 10.1194/jlr.M500124-JLR200

Jonathan C. Cohen, H. Hobbs, Liqing Yu, 2005, Journal of Lipid Research.

ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile Published, JLR Papers in Press, June 1, 2005. DOI 10.1194/jlr.M500115-JLR200

Jonathan C. Cohen, H. Hobbs, Liqing Yu, 2005, Journal of Lipid Research.

Selective sterol accumulation in ABCG5/ABCG8-deficient mice Published, JLR Papers in Press, December 1, 2003. DOI 10.1194/jlr.M300377-JLR200

Jonathan C. Cohen, H. Hobbs, Liqing Yu, 2004, Journal of Lipid Research.

Stimulation of Cholesterol Excretion by the Liver X Receptor Agonist Requires ATP-binding Cassette Transporters G5 and G8*

Jonathan C. Cohen, H. Hobbs, Liqing Yu, 2003, The Journal of Biological Chemistry.

Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface.

Jonathan C. Cohen, H. Hobbs, I. Gelissen, 2002, The Journal of clinical investigation.

Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat.

A. Rigotti, H. Hobbs, Ravindra Kumar Pathak, 1996, The Journal of clinical investigation.

Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8.

Jonathan C. Cohen, S. Grundy, H. Hobbs, 2002, Journal of lipid research.

Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

H. Hobbs, D. Mangelsdorf, J. Repa, 2002, The Journal of biological chemistry.

The Modular Adaptor Protein ARH Is Required for Low Density Lipoprotein (LDL) Binding and Internalization but Not for LDL Receptor Clustering in Coated Pits*

Jonathan C. Cohen, Richard G. W. Anderson, H. Hobbs, 2004, Journal of Biological Chemistry.

Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a).

Robert V Farese, R. Hammer, H. Hobbs, 1993, The Journal of clinical investigation.

Adiposity Amplifies the Genetic Risk of Fatty Liver Disease Conferred by Multiple Loci

Jonathan C. Cohen, H. Hobbs, B. Nordestgaard, 2017, Nature Genetics.

Developmental and hormonal regulation of murine scavenger receptor, class B, type 1.

H. Hobbs, J. Richardson, Liping Zhao, 1999, Molecular endocrinology.

Structure and Localization of the Human Gene Encoding SR-BI/CLA-1

H. Hobbs, K. Wyne, C. Garcia, 1997, The Journal of Biological Chemistry.

Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

Jonathan C. Cohen, H. Hobbs, J. McDonald, 2015, eLife.

Increased thermogenesis by a noncanonical pathway in ANGPTL3/8-deficient mice

Jonathan C. Cohen, H. Hobbs, J. Gromada, 2018, Proceedings of the National Academy of Sciences.

Identification of a VLDL‐induced, FDNPVY‐independent internalization mechanism for the LDLR

Jonathan C. Cohen, H. Hobbs, Wei-ping Li, 2007, The EMBO journal.

Sequences in the Nonconsensus Nucleotide-binding Domain of ABCG5/ABCG8 Required for Sterol Transport*

Jonathan C. Cohen, N. Grishin, H. Hobbs, 2011, The Journal of Biological Chemistry.

The Modular Adaptor Protein Autosomal Recessive Hypercholesterolemia (ARH) Promotes Low Density Lipoprotein Receptor Clustering into Clathrin-coated Pits*

Jonathan C. Cohen, H. Hobbs, R. Gerard, 2005, Journal of Biological Chemistry.

Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis

Jonathan C. Cohen, H. Hobbs, J. Gromada, 2014, Hepatology.

Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins*

Jonathan C. Cohen, H. Hobbs, S. Gilyard, 2016, The Journal of Biological Chemistry.

No association between plasma lipoprotein(a) concentrations and the presence or absence of coronary atherosclerosis in African-Americans.

E. Boerwinkle, H. Hobbs, L. Hillis, 1995, Arteriosclerosis, thrombosis, and vascular biology.

Lipoprotein(a): intrigues and insights.

H. Hobbs, A. White, Ann L. White, 1999, Current opinion in lipidology.

Scavenger Receptor, Class B, Type I-dependent Stimulation of Cholesterol Esterification by High Density Lipoproteins, Low Density Lipoproteins, and Nonlipoprotein Cholesterol*

H. Hobbs, H. Stangl, Guoqing Cao, 1998, The Journal of Biological Chemistry.

Lipoprotein(a) and Apolipoprotein(a) Isoforms: No Association With Coronary Artery Calcification in The Dallas Heart Study

Jonathan C. Cohen, H. Hobbs, Zhaoxia Yu, 2005, Circulation.

Tetranucleotide length polymorphism 5' of the alpha 2-macroglobulin receptor (A2MR)/LDL receptor-related protein (LRP) gene.

H. Hobbs, G. Zuliani, 1994, Human molecular genetics.

Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans.

Eric Boerwinkle, Len A Pennacchio, Jonathan C. Cohen, 2008, The Journal of clinical investigation.

Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

Jonathan C. Cohen, H. Hobbs, A. Murphy, 2020, Journal of Lipid Research.

Genetic Variation in ANGPTL4 Provides Insights into Protein Processing and Function

Jonathan C. Cohen, N. Grishin, H. Hobbs, 2009, Journal of Biological Chemistry.

Dinucleotide repeat polymorphism at the 3' end of the LDL receptor gene.

H. Hobbs, G. Zuliani, 1990, Nucleic acids research.

Deletion in the gene for the low-density-lipoprotein receptor in a majority of French Canadians with familial hypercholesterolemia.

H. Hobbs, D. Russell, M. Brown, 1987, The New England journal of medicine.

Transport of Lipids from High and Low Density Lipoproteins via Scavenger Receptor-BI*

H. Hobbs, H. Stangl, M. Hyatt, 1999, The Journal of Biological Chemistry.

APOC3, coronary disease, and complexities of Mendelian randomization.

Jonathan C. Cohen, H. Hobbs, S. Stender, 2014, Cell metabolism.

Relation between number of apolipoprotein(a) kringle 4 repeats and mobility of isoforms in agarose gel: basis for a standardized isoform nomenclature.

H. Hobbs, S. Marcovina, J. Albers, 1996, Clinical chemistry.

Genetic variant in PNPLA3 is associated with nonalcoholic fatty liver disease in China

Jonathan C. Cohen, H. Hobbs, C. Xing, 2012, Hepatology.

Angiopoietin-like protein 3 (ANGPTL3) governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

Jonathan C. Cohen, H. Hobbs, A. Murphy, 2020 .

Common low-density lipoprotein receptor mutations in the French Canadian population.

H. Hobbs, E. Leitersdorf, J. Davignon, 1990, The Journal of clinical investigation.

Two common low density lipoprotein receptor gene mutations cause familial hypercholesterolemia in Afrikaners.

G. Coetzee, H. Hobbs, E. Leitersdorf, 1989, The Journal of clinical investigation.

Mutations in ATP‐cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia

Jonathan C. Cohen, H. Hobbs, J. Hubacek, 2001, Human mutation.

EcoN I polymorphism in the human cholesteryl ester transfer protein (CEPT) gene.

H. Hobbs, G. Zuliani, 1990, Nucleic acids research.

Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor

Jonathan C. Cohen, H. Hobbs, R. Garuti, 2008, Proceedings of the National Academy of Sciences.

Evidence for a dominant gene that suppresses hypercholesterolemia in a family with defective low density lipoprotein receptors.

H. Hobbs, M. Brown, J. Goldstein, 1989, The Journal of clinical investigation.

Multiple crm- mutations in familial hypercholesterolemia. Evidence for 13 alleles, including four deletions.

H. Hobbs, D. Russell, M. Brown, 1988, The Journal of clinical investigation.

Corrigendum: Low LDL cholesterol in African Americans resulting from frequent nonsense mutations in PCSK9

I. Kotowski, A. Pertsemlidis, H. Hobbs, 2005, Nature Genetics.

No Association Between Plasma Levels of Plant Sterols and Atherosclerosis in Mice and Men

Jonathan C. Cohen, S. Grundy, G. Vega, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Kinetic characteristics and regulation of HDL cholesteryl ester and apolipoprotein transport in the apoA-I 2 / 2 mouse

H. Hobbs, R. S. Meidell, L. Woollett, 1998 .

Tetranucleotide repeat polymorphism in the apolipoprotein B gene.

H. Hobbs, G. Zuliani, 1990, Nucleic acids research.

Transgenic Mice Expressing High Plasma Concentrations of Human Apolipoprotein B 100 and Lipoprotein ( a )

Robert, Chin, H. Hobbs, 2013 .

Low density lipoprotein kinetics in a family having defective low density lipoprotein receptors in which hypercholesterolemia is suppressed.

S. Grundy, G. Vega, H. Hobbs, 1991, Arteriosclerosis and thrombosis : a journal of vascular biology.

Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor

Helen H. Hobbs, Shangzhe Xu, A. Rigotti, 1996, Science.

Polyunsaturated fatty acids up-regulate hepatic scavenger receptor B1 (SR-BI) expression and HDL cholesteryl ester uptake in the hamster.

H. Hobbs, D. Kearney, D. Spady, 1999, Journal of lipid research.

Regulation of the very low density lipoprotein receptor by thyroid hormone in rat skeletal muscle.

H. Hobbs, K. Wyne, Y. Ho, 1994, The Journal of biological chemistry.

Patatin‐like phospholipase domain‐containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease

Jonathan C. Cohen, H. Hobbs, J. Browning, 2010, Hepatology.

ABC1: connecting yellow tonsils, neuropathy, and very low HDL.

D. Rader, H. Hobbs, 1999, The Journal of clinical investigation.

Homozygosity mapping identifies a bile acid biosynthetic defect in an adult with cirrhosis of unknown etiology

Jonathan C. Cohen, H. Hobbs, C. Xing, 2012, Hepatology.

High-level expression of ABCG5 and ABCG8 attenuates diet-induced hypercholesterolemia and atherosclerosis in Ldlr (cid:2) / (cid:2) mice

Jonathan C. Cohen, H. Hobbs, Liqing Yu, 2004 .

Dual roles for cholesterol in mammalian cells.

Jonathan C. Cohen, H. Hobbs, R. B. Rawson, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Mutational Analysis of a Menabrane Protein

H. Hobbs, D. Russell, J. Goldstein, 1990 .

Molecular mechanisms of autosomal recessive hypercholesterolemia.

Jonathan C. Cohen, H. Hobbs, J. Garcia, 2002, Human molecular genetics.

Deletion of exon encoding cysteine-rich repeat of low density lipoprotein receptor alters its binding specificity in a subject with familial hypercholesterolemia.

H. Hobbs, D. Russell, M. Brown, 1986, The Journal of biological chemistry.

The LDL receptor in familial hypercholesterolemia: use of human mutations to dissect a membrane protein.

T. Südhof, H. Hobbs, D. Russell, 1986, Cold Spring Harbor symposia on quantitative biology.

Polymorphism and evolution of Alu sequences in the human low density lipoprotein receptor gene.

H. Hobbs, D. Russell, M. Lehrman, 1985, Proceedings of the National Academy of Sciences of the United States of America.

LDL Receptor Mutations in Patients with Familial Hypercholesterolemia

H. Hobbs, D. Russell, J. Goldstein, 1987 .

Reconstitution of lipoprotein(a) by infusion of human low density lipoprotein into transgenic mice expressing human apolipoprotein(a).

R. Hammer, M. Koschinsky, H. Hobbs, 1992, The Journal of biological chemistry.

HSD17B13 and Chronic Liver Disease in Blacks and Hispanics.

Jonathan C. Cohen, H. Hobbs, S. Stender, 2018, The New England journal of medicine.

Comparative analysis of the apo(a) gene, apo(a) glycoprotein, and plasma concentrations of Lp(a) in three ethnic groups. Evidence for no common "null" allele at the apo(a) locus.

E. Boerwinkle, H. Hobbs, A. Gaw, 1994, The Journal of clinical investigation.

Human LDL receptor gene: HincII polymorphism detected by gene amplification.

H. Hobbs, E. Leitersdorf, 1988, Nucleic acids research.

Apolipoprotein(a) kringle 4-containing fragments in human urine. Relationship to plasma levels of lipoprotein(a).

H. Hobbs, V. Mooser, M. Abedin, 1996, The Journal of clinical investigation.

Kringle-containing fragments of apolipoprotein(a) circulate in human plasma and are excreted into the urine.

H. Hobbs, V. Mooser, S. Marcovina, 1996, The Journal of clinical investigation.

Functional Asymmetry of Nucleotide-binding Domains in ABCG5 and ABCG8*

Jonathan C. Cohen, H. Hobbs, R. Gerard, 2006, Journal of Biological Chemistry.

Determinants of human apolipoprotein [a] secretion from mouse hepatocyte cultures.

H. Hobbs, A. White, J. Wang, 2001, Journal of lipid research.

Lipoprotein(a) and growth hormone: is the puzzle solved?

H. Hobbs, V. Mooser, 1997, European journal of endocrinology.

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

Anne Tybjærg-Hansen, Børge G. Nordestgaard, Jonathan C. Cohen, 2014, Nature Genetics.

Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets.

Jonathan C. Cohen, H. Hobbs, Michael A. Mitsche, 2018, The Journal of Biological Chemistry.

Autosomal recessive hypercholesterolaemia in Sardinia, Italy, and mutations in ARH: a clinical and molecular genetic analysis

Jonathan C. Cohen, H. Hobbs, N. Glorioso, 2002, The Lancet.

Transgenic mice expressing a human apolipoprotein[a] allele.

R. Hammer, H. Hobbs, V. Mooser, 1999, Journal of lipid research.

Contribution of a genetic risk score to ethnic differences in fatty liver disease

H. Hobbs, J. Kozlitina, Maddie J Kubiliun, 2022, Liver international : official journal of the International Association for the Study of the Liver.

High plasma levels of apo(a) fragments in Caucasians and African‐Americans with end‐stage renal disease: implications for plasma Lp(a) assay

H. Hobbs, V. Mooser, S. Marcovina, 1997, Clinical genetics.

Apo(a) Expression in Transgenic Mice a

R. Hammer, M. Koschinsky, H. Hobbs, 1994, Annals of the New York Academy of Sciences.

Deletion in the first cysteine-rich repeat of low density lipoprotein receptor impairs its transport but not lipoprotein binding in fibroblasts from a subject with familial hypercholesterolemia.

G. Coetzee, H. Hobbs, A. Fourie, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Molecular genetics of lipoprotein (a): new pieces to the puzzle.

H. Hobbs, A. Gaw, Helen H. Hobbs, 1994, Current opinion in lipidology.

Tetranucleotide repeat polymorphism in the apolipoprotein C-III gene.

H. Hobbs, G. Zuliani, 1990, Nucleic acids research.

Sequence microheterogeneity in apolipoprotein(a) gene repeats and the relationship to plasma Lp(a) levels.

H. Hobbs, V. Mooser, F. Mancini, 1995, Human molecular genetics.

Sequence polymorphisms in the apo(a) gene associated with specific levels of Lp(a) in plasma.

E. Boerwinkle, H. Hobbs, V. Mooser, 1995, Human molecular genetics.

No association between polymorphism in PEMT (V175M) and hepatic triglyceride content in the Dallas Heart Study

Jonathan C. Cohen, H. Hobbs, S. Romeo, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Relative contributions of apolipoprotein(a) and apolipoprotein-B to the development of fatty lesions in the proximal aorta of mice.

R. Hammer, H. Hobbs, V. Mooser, 1995, Arteriosclerosis, thrombosis, and vascular biology.

Cloning of the human cholesterol 7 alpha-hydroxylase gene (CYP7) and localization to chromosome 8q11-q12.

Jonathan C. Cohen, H. Hobbs, D. Russell, 1992, Genomics.

Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

Jonathan C. Cohen, R. Hammer, H. Hobbs, 2002, Proceedings of the National Academy of Sciences of the United States of America.

High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase

Richard G. W. Anderson, H. Hobbs, Y. Marcel, 2001, Nature Medicine.

The Apo(a) gene is the major determinant of variation in plasma Lp(a) levels in African Americans.

H. Hobbs, V. Mooser, S. Marcovina, 1997, American journal of human genetics.

Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations.

E. Boerwinkle, H. Hobbs, G. Chiesa, 1992, The Journal of clinical investigation.

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

Nick V. Grishin, Jonathan C. Cohen, Helen H. Hobbs, 2009, The Journal of Biological Chemistry.

ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol Excretion*

Jonathan C. Cohen, H. Hobbs, R. Gerard, 2003, Journal of Biological Chemistry.

CGG triple repeat polymorphism in VLDL receptor (VLDL-R) gene.

H. Hobbs, T. Yamamoto, E. Jokinen, 1994, Human molecular genetics.

Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride

Jonathan C. Cohen, D. Dickel, L. Pennacchio, 2018, Hepatology.

ARH Is a Modular Adaptor Protein That Interacts with the LDL Receptor, Clathrin, and AP-2*

Jonathan C. Cohen, H. Hobbs, Ming Yi, 2002, The Journal of Biological Chemistry.

Autosomal Recessive Hypercholesterolemia Caused by Mutations in a Putative LDL Receptor Adaptor Protein

Jonathan C. Cohen, N. Grishin, H. Hobbs, 2001, Science.

Adult-onset liver disease and hepatocellular carcinoma in S-adenosylhomocysteine hydrolase deficiency.

Jonathan C. Cohen, H. Hobbs, C. Xing, 2015, Molecular genetics and metabolism.

Tetranucleotide repeat polymorphism in the LPL gene.

H. Hobbs, G. Zuliani, 1990, Nucleic Acids Research.

Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin

Jonathan C. Cohen, H. Hobbs, J. Kozlitina, 2017, eLife.

Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets

Jonathan C. Cohen, H. Hobbs, Matthew A. Mitsche, 2018, The Journal of Biological Chemistry.

Dissociation Between APOC3 Variants, Hepatic Triglyceride Content and Insulin Resistance

Jonathan C. Cohen, E. Boerwinkle, H. Hobbs, 2011, Hepatology.

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

Alexander Pertsemlidis, Eric Boerwinkle, Chao Xing, 2008, Nature Genetics.

Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13.

H. Hobbs, M. Brown, X. Hua, 1995, Genomics.

Polymorphic DNA haplotypes at the LDL receptor locus.

A. Chakravarti, H. Hobbs, E. Leitersdorf, 1989, American journal of human genetics.

Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL

Eric Boerwinkle, Yunxin Fu, Len A Pennacchio, 2007, Nature Genetics.

Expression of the VLDL receptor in endothelial cells.

H. Hobbs, K. Wyne, M. Seabra, 1996, Arteriosclerosis, thrombosis, and vascular biology.

Molecular basis of apolipoprotein (a) isoform size heterogeneity as revealed by pulsed-field gel electrophoresis.

E. Boerwinkle, H. Hobbs, C. Leffert, 1991, The Journal of clinical investigation.

Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis

Jonathan C. Cohen, H. Hobbs, Yang Wang, 2019, Proceedings of the National Academy of Sciences.

Functional characterization of genetic variants in NPC1L1 supports the sequencing extremes strategy to identify complex trait genes

Jonathan C. Cohen, H. Hobbs, Saleemah Fahmi, 2008, Human molecular genetics.

Identification by whole-genome resequencing of gene defect responsible for severe hypercholesterolemia

Jay Shendure, Jonathan C. Cohen, Helen H. Hobbs, 2010, Human molecular genetics.

Sequence diversity in genes of lipid metabolism.

N. Patil, H. Hobbs, Y. Liao, 2001, Genome research.

Monogenic hypercholesterolemia: new insights in pathogenesis and treatment.

Jonathan D. Cohen, D. Rader, H. Hobbs, 2003, The Journal of clinical investigation.

Molecular genetics of the LDL receptor gene in familial hypercholesterolemia

H. Hobbs, J. Goldstein, Michael S. Brown, 1992, Human mutation.

Deletion of GPIHBP1 causing severe chylomicronemia

Jonathan C. Cohen, H. Hobbs, N. Hauser, 2011, Journal of Inherited Metabolic Disease.

The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein.

H. Hobbs, D. Russell, M. Brown, 1990, Annual review of genetics.

Human growth hormone increases apo(a) expression in transgenic mice.

H. Hobbs, F. Acquati, S. Marcovina, 1999, Arteriosclerosis, thrombosis, and vascular biology.

High-level expression of ABCG5 and ABCG8 attenuates diet-induced hypercholesterolemia and atherosclerosis in Ldlr−/− mice Published, JLR Papers in Press, June 1, 2004. DOI 10.1194/jlr.M400167-JLR200

Jonathan C. Cohen, H. Hobbs, Liqing Yu, 2004, Journal of Lipid Research.

Expression of human apolipoprotein B100 in transgenic mice. Editing of human apolipoprotein B100 mRNA.

R. Mahley, H. Hobbs, S. Young, 1993, The Journal of biological chemistry.

Molecular mechanisms of autosomal recessive hypercholesterolemia

Jonathan C. Cohen, H. Hobbs, M. Kimmel, 2003, Current opinion in lipidology.

Molecular basis of cholesterol efflux via ABCG subfamily transporters

Jonathan C. Cohen, H. Hobbs, Xiaochun Li, 2021, Proceedings of the National Academy of Sciences.

Crystal structure of the human sterol transporter ABCG5/ABCG8

Jonathan C. Cohen, H. Hobbs, L. Kinch, 2016, Nature.

Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation*

Jonathan C. Cohen, H. Hobbs, J. Horton, 2007, Journal of Biological Chemistry.

Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface

Jonathan C. Cohen, H. Hobbs, I. Gelissen, 2002 .

A high frequency of length polymorphisms in repeated sequences adjacent to Alu sequences.

H. Hobbs, G. Zuliani, 1990, American journal of human genetics.

Sequence Variations in PCSK 9 , Low LDL , and Protection against Coronary Heart Disease

Eric Boerwinkle, Jonathan C. Cohen, Helen H. Hobbs, 2006 .

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys1[S]

Jonathan C. Cohen, H. Hobbs, A. Murphy, 2015, Journal of Lipid Research.

Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats

Jonathan C. Cohen, H. Hobbs, S. Martin, 2021, Cellular and molecular gastroenterology and hepatology.

A Protein‐Truncating HSD17B13 Variant and Protection from Chronic Liver Disease

Alexander E. Lopez, Tanya M. Teslovich, Alexander Hanbo Li, 2018, The New England journal of medicine.

Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2).

H. Hobbs, A. Miserez, Guoqing Cao, 1997, Genomics.

Expression of human apolipoprotein B90 in transgenic mice. Demonstration that apolipoprotein B90 lacks the structural requirements to form lipoprotein.

H. Hobbs, S. Young, M. Linton, 1994, The Journal of biological chemistry.

Sequence polymorphisms in the apolipoprotein (a) gene. Evidence for dissociation between apolipoprotein(a) size and plasma lipoprotein(a) levels.

H. Hobbs, G. Chiesa, J. Cohen, 1993, The Journal of clinical investigation.

Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: no accentuation by apolipoprotein(a).

R. Hammer, H. Hobbs, V. Mooser, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Genetic factors that contribute to interindividual variations in plasma low density lipoprotein-cholesterol levels.

H. Hobbs, A. Gaw, R. Barnes, 1996, Ciba Foundation symposium.

PCSK9: a convertase that coordinates LDL catabolism Published, JLR Papers in Press, November 19, 2008.

Jonathan C. Cohen, H. Hobbs, J. Horton, 2009, Journal of Lipid Research.

Molecular definition of the extreme size polymorphism in apolipoprotein(a).

H. Hobbs, J. Cohen, C. Lackner, 1993, Human molecular genetics.

Disruption of cholesterol homeostasis by plant sterols.

Jonathan C. Cohen, H. Hobbs, Wei-ping Li, 2004, The Journal of clinical investigation.

Missense Mutations in ABCG5 and ABCG8 Disrupt Heterodimerization and Trafficking*

Jonathan C. Cohen, H. Hobbs, G. Graf, 2004, Journal of Biological Chemistry.

Genetic and Metabolic Determinants of Plasma Levels of ANGPTL8

Jonathan C. Cohen, H. Hobbs, V. Gusarova, 2021, The Journal of clinical endocrinology and metabolism.

Normal Sorting but Defective Endocytosis of the Low Density Lipoprotein Receptor in Mice with Autosomal Recessive Hypercholesterolemia*

Jonathan C. Cohen, R. Hammer, H. Hobbs, 2003, Journal of Biological Chemistry.

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation

Jonathan C. Cohen, H. Hobbs, Ē. Šmagris, 2017, Hepatology.

Molecular biology of PCSK9: its role in LDL metabolism.

Jonathan C. Cohen, H. Hobbs, J. Horton, 2007, Trends in biochemical sciences.

Genetic defenses against hypercholesterolemia.

H. Hobbs, G. Graf, K. Wilund, 2002, Cold Spring Harbor symposia on quantitative biology.

Lawrence Berkeley National Laboratory Recent Work Title Relationship between genetic variation at PPP 1 R 3 B and levels of liver glycogen and triglyceride Permalink

Jonathan C. Cohen, D. Dickel, L. Pennacchio, 2018 .

Simple Genetics for a Complex Disease

Jonathan C. Cohen, Helen H. Hobbs, H. Hobbs, 2013, Science.

Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia.

Jonathan C. Cohen, H. Hobbs, N. Maeda, 2007, The Journal of clinical investigation.

African Americans and Caucasians have a similar prevalence of coronary calcium in the Dallas Heart Study.

S. Grundy, G. Vega, H. Hobbs, 2004, Journal of the American College of Cardiology.

WholePathwayScope: a comprehensive pathway-based analysis tool for high-throughput data

Ming Yi, Robert M. Stephens, Jay D. Horton, 2006, BMC Bioinformatics.

Missense variant in insulin receptor (Y1355H) segregates in family with fatty liver disease

Jonathan C. Cohen, H. Hobbs, G. Liang, 2021, Molecular metabolism.

ANGPTL8 has both endocrine and autocrine effects on substrate utilization

Jonathan C. Cohen, H. Hobbs, S. Banfi, 2020, JCI insight.

PNPLA3, CGI‐58, and Inhibition of Hepatic Triglyceride Hydrolysis in Mice

Jonathan C. Cohen, H. Hobbs, Nora Kory, 2019, Hepatology.

Genetic and metabolic determinants of plasma PCSK9 levels.

Jonathan C. Cohen, H. Hobbs, J. Horton, 2009, The Journal of clinical endocrinology and metabolism.

Indices of cholesterol metabolism and relative responsiveness to ezetimibe and simvastatin.

Jonathan C. Cohen, S. Grundy, G. Vega, 2010, The Journal of clinical endocrinology and metabolism.

Expression of ABCG5 and ABCG8 Is Required for Regulation of Biliary Cholesterol Secretion*

Jonathan C. Cohen, H. Hobbs, D. Mangelsdorf, 2005, Journal of Biological Chemistry.

A feed-forward loop amplifies nutritional regulation of PNPLA3

Jonathan C. Cohen, H. Hobbs, T. Osborne, 2010, Proceedings of the National Academy of Sciences.

Sterol Transfer by ABCG5 and ABCG8

Jonathan C. Cohen, H. Hobbs, Da-Wei Zhang, 2006, Journal of Biological Chemistry.

Erratum: Patatin-like phospholipase domain-containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets (Journal of Biological Chemistry (2018) 293 (6958-6968) DOI: 10.1074/jbc.RA118.002333)

Jonathan C. Cohen, H. Hobbs, Michael A. Mitsche, 2018 .

Human LDL receptor gene: two ApaLI RFLPs.

H. Hobbs, E. Leitersdorf, 1987, Nucleic acids research.

Molecular basis of familial hypercholesterolemia.

H. Hobbs, D. Russell, V. Esser, 1989, Arteriosclerosis.

Overexpression of ABCG 5 and ABCG 8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

Jonathan C. Cohen, R. Hammer, H. Hobbs, 2018 .

Kinetic characteristics and regulation of HDL cholesteryl ester and apolipoprotein transport in the apoA-I-/- mouse.

H. Hobbs, R. S. Meidell, L. Woollett, 1998, Journal of lipid research.

Hepatic triglyceride content in individuals with reduced intestinal cholesterol absorption due to variants in Nieman Pick C1‐like 1

Jonathan C. Cohen, H. Hobbs, R. Ramirez, 2011, Hepatology.

Human Fatty Liver Disease: Old Questions and New Insights

Jonathan C. Cohen, H. Hobbs, J. Horton, 2011, Science.

Common low-density lipoprotein receptor mutations in the French Canadian population.

H. Hobbs, E. Leitersdorf, J. Davignon, 1990, The Journal of clinical investigation.

Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets

Jonathan C. Cohen, H. Hobbs, Matthew A. Mitsche, 2018, The Journal of Biological Chemistry.

HSD17B13 and Chronic Liver Disease in Blacks and Hispanics.

Jonathan C. Cohen, H. Hobbs, S. Stender, 2018, The New England journal of medicine.

Genetic variant in PNPLA3 is associated with nonalcoholic fatty liver disease in China

Jonathan C. Cohen, H. Hobbs, Yiling Li, 2012, Hepatology.

Patatin‐like phospholipase domain‐containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease

Jonathan C. Cohen, H. Hobbs, J. Browning, 2010, Hepatology.

Lipoprotein(a) and Apolipoprotein(a) Isoforms: No Association With Coronary Artery Calcification in The Dallas Heart Study

Jonathan C. Cohen, H. Hobbs, Zhaoxia Yu, 2005, Circulation.

APOC3, coronary disease, and complexities of Mendelian randomization.

Jonathan C. Cohen, H. Hobbs, S. Stender, 2014, Cell metabolism.