B. Fermini

发表

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative - Update on progress.

T. Colatsky, B. Fermini, G. Gintant, 2016, Journal of pharmacological and toxicological methods.

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century

Gary R. Mirams, J. Skinner, B. Fermini, 2016, The Journal of physiology.

The impact of drug-induced QT interval prolongation on drug discovery and development

B. Fermini, A. Fossa, 2003, Nature Reviews Drug Discovery.

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

T. Colatsky, B. Fermini, G. Gintant, 2016, Journal of biomolecular screening.

Publisher Correction: Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells

B. Fermini, G. Gintant, Jennifer B Pierson, 2020, Scientific Reports.

Cardiac voltage-gated ion channels in safety pharmacology: Review of the landscape leading to the CiPA initiative.

Simon Authier, Michael J Curtis, Michael K Pugsley, 2017, Journal of pharmacological and toxicological methods.

Evaluation of the rubidium efflux assay for preclinical identification of HERG blockade.

Robert H Gallavan, B. Fermini, A. Bahinski, 2006, Assay and drug development technologies.

Pharmacokinetic-pharmacodynamic modelling of the effect of Moxifloxacin on QTc prolongation in telemetered cynomolgus monkeys.

B. Fermini, P. H. van der Graaf, M. Holbrook, 2011, Journal of pharmacological and toxicological methods.

Amiodarone: Pharmacology, Clinical Actions, and Relationships Between Them

B. Fermini, S. Nattel, M. Talajic, 1992 .

Current inHumanAtrial Myocytes Evidence fora NovelDelayed Rectifier K'Current Similar to Kvl.5ClonedChannel Currents

B. Fermini, S. Nattel, 1993 .

On the perspective of an aging population and its potential impact on drug attrition and pre-clinical cardiovascular safety assessment.

B. Fermini, D. Bell, 2022, Journal of pharmacological and toxicological methods.

Pre-Clinical Assessment of Drug-Induced QT Interval Prolongation. Current Issues and Impact on Drug Discovery

B. Fermini, A. Fossa, 2004 .

α-Adrenergic Control of Volume-Regulated Cl− Currents in Rabbit Atrial Myocytes

B. Fermini, S. Nattel, D. Duan, 1995 .

Modeling the heart with Novoheart’s MyHeart™ platform

Ronald A. Li, K. Costa, B. Fermini, 2020 .

Role of chloride currents in repolarizing rabbit atrial myocytes.

B. Fermini, S. Nattel, Jianlin Feng, 1995, The American journal of physiology.

Deranged sodium to sudden death

B. Fermini, J. Weiss, Z. Qu, 2015, The Journal of physiology.

Disruption of sodium homeostasis in cardiac disease In the session on ‘ Disruption of Na + homeostasis

B. Fermini, J. Weiss, Z. Qu, 2015 .

Class I Drug Effects on the Atrium

B. Fermini, S. Nattel, G. O'hara, 1992 .

Adrenergic modulation of ultrarapid delayed rectifier K+ current in human atrial myocytes.

B. Fermini, S. Nattel, G. Li, 1996, Circulation research.

Mechanism of action potential prolongation by RP 58866 and its active enantiomer, terikalant. Block of the rapidly activating delayed rectifier K+ current, IKr.

B. Fermini, M. Sanguinetti, M C Sanguinetti, 1996, Circulation.

Novel, Potent inhibitors of human Kv1.5 K channels and IKur

B. Fermini, J. Salata, A. Lagrutta, 2006 .

Choline chloride activates time-dependent and time-independent K+ currents in dog atrial myocytes.

B. Fermini, S. Nattel, 1994, The American journal of physiology.

Effects of flecainide, quinidine, and 4-aminopyridine on transient outward and ultrarapid delayed rectifier currents in human atrial myocytes.

B. Fermini, S. Nattel, Zhiguo Wang, 1995, The Journal of pharmacology and experimental therapeutics.

Repolarization differences between guinea pig atrial endocardium and epicardium: evidence for a role of Ito.

B. Fermini, S. Nattel, Zhiguo Wang, 1991, The American journal of physiology.

Mechanism of flecainide's rate-dependent actions on action potential duration in canine atrial tissue.

B. Fermini, S. Nattel, Z. Wang, 1993, The Journal of pharmacology and experimental therapeutics.

Modulation of flecainide's cardiac sodium channel blocking actions by extracellular sodium: a possible cellular mechanism for the action of sodium salts in flecainide cardiotoxicity.

B. Fermini, S. Nattel, R. Sheldon, 1993, The Journal of pharmacology and experimental therapeutics.

Human Cardiac Ventricular‐Like Organoid Chambers and Tissue Strips From Pluripotent Stem Cells as a Two‐Tiered Assay for Inotropic Responses

Ronald A. Li, Eugene K. Lee, K. Costa, 2019, Clinical pharmacology and therapeutics.

Alpha-adrenergic control of volume-regulated Cl- currents in rabbit atrial myocytes. Characterization of a novel ionic regulatory mechanism.

B. Fermini, S. Nattel, D. Duan, 1995, Circulation research.

Determinants of action potential duration in neonatal rat ventricle cells.

B. Fermini, O. Schanne, 1991, Cardiovascular research.

Cardiac sodium channel antagonism - Translation of preclinical in vitro assays to clinical QRS prolongation.

David S. Ramirez, B. Fermini, Donglin Guo, 2018, Journal of pharmacological and toxicological methods.

Rapid and slow components of delayed rectifier current in human atrial myocytes.

B. Fermini, S. Nattel, Zhiguo Wang, 1994, Cardiovascular research.

Delayed rectifier outward current and repolarization in human atrial myocytes.

S Nattel, B. Fermini, S. Nattel, 1993, Circulation research.

Comparative gene expression profiling in human-induced pluripotent stem cell--derived cardiocytes and human and cynomolgus heart tissue.

B. Fermini, M. Pletcher, B. Anson, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Challenges in designing and executing clinical trials in a dish studies.

B. Fermini, K. Coyne, Shawn T. Coyne, 2018, Journal of pharmacological and toxicological methods.

A bilayer small diameter in vitro vascular model for evaluation of drug induced vascular injury.

J. Vacanti, B. Fermini, J. Borenstein, 2016, Biomicrofluidics.

Sustained depolarization-induced outward current in human atrial myocytes. Evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channel currents.

S Nattel, B. Fermini, S. Nattel, 1993, Circulation research.

Differences in rate dependence of transient outward current in rabbit and human atrium.

B. Fermini, S. Nattel, Zhiguo Wang, 1992, The American journal of physiology.

L-type calcium channel antagonism - Translation from in vitro to in vivo.

David S. Ramirez, B. Fermini, T. Wisialowski, 2017, Journal of pharmacological and toxicological methods.

The Evolving Roles of Human iPSC-Derived Cardiomyocytes in Drug Safety and Discovery.

Gary Gintant, Norman Stockbridge, David Strauss, 2017, Cell stem cell.

Clinical Trials in a Dish: A Perspective on the Coming Revolution in Drug Development

B. Fermini, K. Coyne, Shawn T. Coyne, 2018, SLAS discovery : advancing life sciences R & D.

Sialic acid and the surface charge associated with hyperpolarization-activated, inward rectifying channels

B. Fermini, R. D. Nathan, 1990, The Journal of Membrane Biology.

Identity of a novel delayed rectifier current from human heart with a cloned K+ channel current.

B. Fermini, A. Brown, S. Nattel, 1993, Circulation research.

Removal of sialic acid alters both T- and L-type calcium currents in cardiac myocytes.

B. Fermini, R D Nathan, B Fermini, 1991, The American journal of physiology.

The human ether-a'-go-go related gene (hERG) K+ channel blockade by the investigative selective-serotonin reuptake inhibitor CONA-437: limited dependence on S6 aromatic residues.

B. Fermini, J. Hancox, A. Alexandrou, 2014, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Proarrhythmia liability assessment and the comprehensive in vitro Proarrhythmia Assay (CiPA): An industry survey on current practice.

Jean-Pierre Valentin, Hugo M Vargas, Simon Authier, 2017, Journal of pharmacological and toxicological methods.

Novel method for action potential measurements from intact cardiac monolayers with multiwell microelectrode array technology

Stacie A. Chvatal, Daniel C Millard, B. Fermini, 2019, Scientific Reports.

Differentiation of Arrhythmia Risk of the Antibacterials Moxifloxacin, Erythromycin, and Telithromycin Based on Analysis of Monophasic Action Potential Duration Alternans and Cardiac Instability

B. Fermini, K. Crimin, T. Wisialowski, 2006, Journal of Pharmacology and Experimental Therapeutics.

Novel, Potent Inhibitors of Human Kv1.5 K+ Channels and Ultrarapidly Activating Delayed Rectifier Potassium Current

B. Fermini, J. Salata, A. Lagrutta, 2006, Journal of Pharmacology and Experimental Therapeutics.

IK of rabbit ventricle is composed of two currents: evidence for IKs.

B. Fermini, R. Swanson, K. Folander, 1996, The American journal of physiology.

Sustained outward current observed after I(to1) inactivation in rabbit atrial myocytes is a novel Cl- current.

B. Fermini, S. Nattel, D. Duan, 1992, The American journal of physiology.

Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells

B. Fermini, G. Gintant, Jennifer B Pierson, 2020, Scientific Reports.

Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.

Todd Wisialowski, B. Fermini, D. Raunig, 2004, European journal of pharmacology.

Use‐Dependent Effects of the Class III Antiarrhythmic Agent NE‐10064 (Azimilide) on Cardiac Repolarization: Block of Delayed Rectifier Potassium and L‐Type Calcium Currents

B. Fermini, J. Lynch, E. Baskin, 1995, Journal of cardiovascular pharmacology.

Comparative mechanisms of 4-aminopyridine-resistant Ito in human and rabbit atrial myocytes.

B. Fermini, S. Nattel, G. Li, 1995, The American journal of physiology.

Potassium channel blocking properties of propafenone in rabbit atrial myocytes.

B. Fermini, S. Nattel, D. Duan, 1993, The Journal of pharmacology and experimental therapeutics.

Recent Advances in Ion Channel Screening Technologies

B. Fermini, 2008 .

Use of automated patch clamp in cardiac safety assessment: Past, present & future perspectives.

B. Fermini, D. Bell, 2021, Journal of pharmacological and toxicological methods.

Use of automated patch clamp in cardiac safety assessment: Past, present and future perspectives.

B. Fermini, D. Bell, 2021, Journal of pharmacological and toxicological methods.

Properties of sodium and potassium currents of cultured adult human atrial myocytes.

B. Fermini, S. Nattel, G. Li, 1996, The American journal of physiology.

Measuring kinetics and potency of hERG block for CiPA.

Monique J Windley, Najah Abi-Gerges, Bernard Fermini, 2017, Journal of pharmacological and toxicological methods.