Y. Sekino

发表

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative - Update on progress.

T. Colatsky, B. Fermini, G. Gintant, 2016, Journal of pharmacological and toxicological methods.

GABAergic Interneurons Facilitate Mossy Fiber Excitability in the Developing Hippocampus

Y. Sekino, Michiko Nakamura, T. Manabe, 2007, The Journal of Neuroscience.

1410 External stimulastion changed spatial and temporal patterns of synchronous oscillation in self-organized cortical neuronal network

K. Muramoto, M. Kawahara, Kazuo Kobayashi, 1993 .

International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment

Daniel C Millard, G. Gintant, Jennifer B Pierson, 2018, Cell reports.

Prenatal exposure to valproic acid alters the development of excitability in the postnatal rat hippocampus

Y. Sekino, S. Yoshida, S. Ueno, 2018, Neurotoxicology.

A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes.

Yasunari Kanda, Takashi Yoshinaga, Kohei Sawada, 2017, Journal of pharmacological and toxicological methods.

Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs.

Yasunari Kanda, Tetsuo Sasano, Junko Kurokawa, 2017, Journal of pharmacological sciences.

Quantitative analysis of intraneuronal transport in human iPS neurons.

Y. Sekino, Y. Goshima, F. Tanaka, 2015, Journal of pharmacological sciences.

Specific induction and long-term maintenance of high purity ventricular cardiomyocytes from human induced pluripotent stem cells

Y. Sekino, Y. Yoshida, M. Kawatou, 2020, PloS one.

Lesions of the Supramammillary Nucleus Decrease Self-Grooming Behavior of Rats Placed in an Open Field

T. Shirao, Y. Sekino, M. Saji, 2011 .

Required research activities to overcome addiction problems in Japan

M. Kawato, S. Yamawaki, T. Shirao, 2021 .

Chlorpyrifos inhibits neural induction via Mfn1-mediated mitochondrial dysfunction in human induced pluripotent stem cells

Y. Sekino, Y. Kanda, D. Yamazaki, 2017, Scientific Reports.

Reduced Basal and LPS-Stimulated A 1 AR Expression in the Brain of NF- κ B p50 − / − Mice

Vickram, Y. Sekino, L. Toth, 2007 .

Reduced basal and lipopolysaccharide-stimulated adenosine A1 receptor expression in the brain of nuclear factor-κB p50−/− mice

Y. Sekino, L. Toth, V. Ramkumar, 2007, Neuroscience.

Systematic expression analysis of genes related to generation of action potentials in human iPS cell-derived cardiomyocytes.

Y. Sekino, T. Furukawa, Y. Kurachi, 2019, Journal of pharmacological sciences.

Appraisal of state-ofthe-art Improvement of acquisition and analysis methods in multi-electrode array experiments with iPS cell-derived cardiomyocytes

Y. Sekino, K. Sawada, Tomoharu Osada, 2015 .

Early‐stage development of human induced pluripotent stem cell‐derived neurons

T. Shirao, Y. Sekino, Noriko Koganezawa, 2015, Journal of neuroscience research.

Many faces of drebrin: from building dendritic spines and stabilizing gap junctions to shaping neurite-like cell processes

T. Shirao, Y. Sekino, I. Majoul, 2007, Histochemistry and Cell Biology.

Osmotic Diuretics Induce Adenosine A1 Receptor Expression and Protect Renal Proximal Tubular Epithelial Cells against Cisplatin-mediated Apoptosis*

Y. Sekino, S. Pingle, L. Rybak, 2004, Journal of Biological Chemistry.

Neurons Induce Tiled Astrocytes with Branches That Avoid Each Other

Y. Sekino, M. Hayashi, Kaoru Sato, 2022, International journal of molecular sciences.

Development of correction formula for field potential duration of human induced pluripotent stem cell-derived cardiomyocytes sheets.

Y. Sekino, A. Naito, Y. Kanda, 2017, Journal of Pharmacological Sciences.

Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation.

Y. Sekino, Y. Shigemoto-mogami, Takeshi Suzuki, 2015, Journal of pharmacological sciences.

Nicotine induces mitochondrial fission through mitofusin degradation in human multipotent embryonic carcinoma cells.

Y. Sekino, Y. Kanda, Naoya Hirata, 2016, Biochemical and biophysical research communications.

Endogenous adenosine protects CA1 neurons from kainic acid‐induced neuronal cell loss in the rat hippocampus

Y. Sekino, K. Takata, Y. Kitamura, 1999, The European journal of neuroscience.

Niflumic acid activates additional currents of the human glial L-glutamate transporter EAAT1 in a substrate-dependent manner.

Y. Sekino, K. Nakazawa, Kaoru Sato, 2013, Biological & pharmaceutical bulletin.

Assessment of NMDA receptor inhibition of phencyclidine analogues using a high-throughput drebrin immunocytochemical assay.

T. Shirao, Y. Sekino, Noriko Koganezawa, 2019, Journal of pharmacological and toxicological methods.

Tributyltin induces mitochondrial fission through Mfn1 degradation in human induced pluripotent stem cells.

Y. Sekino, Y. Kanda, Naoya Hirata, 2016, Toxicology in vitro : an international journal published in association with BIBRA.

Tributyltin induces mitochondrial fission through NAD-IDH dependent mitofusin degradation in human embryonic carcinoma cells.

Y. Sekino, Y. Kotake, Y. Kanda, 2015, Metallomics : integrated biometal science.

NMDA receptor‐dependent and ‐independent effects of natural compounds and crude drugs on synaptic states as revealed by drebrin imaging analysis

T. Shirao, Y. Sekino, Noriko Koganezawa, 2020, The European journal of neuroscience.

Tributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells

Y. Sekino, S. Yoshida, Y. Kanda, 2018, Scientific Reports.

Tributyltin induces G2/M cell cycle arrest via NAD(+)-dependent isocitrate dehydrogenase in human embryonic carcinoma cells.

Y. Sekino, Y. Kotake, Y. Kanda, 2016, The Journal of toxicological sciences.

Comparative metabolome analysis of cultured fetal and adult hepatocytes in humans.

M. Usami, Y. Sekino, T. Matsuo, 2014, The Journal of toxicological sciences.

Discovery of a Tamoxifen-related compound that suppresses glial l-glutamate transport activity without interaction with estrogen receptors.

Yoshihiko Saito, Y. Sekino, T. Ohwada, 2012, ACS chemical neuroscience.

Residual metals in carbon nanotubes suppress the proliferation of neural stem cells

Y. Sekino, A. Hirose, Y. Ikarashi, 2014 .

AMP-activated protein kinase-mediated glucose transport as a novel target of tributyltin in human embryonic carcinoma cells.

Y. Sekino, Y. Kotake, Y. Kanda, 2013, Metallomics : integrated biometal science.

Adenosine (A2) antagonist inhibits induction of long-term potentiation of evoked synaptic potentials but not of the population spike in hippocampal CA1 neurons.

Y. Kuroda, Y. Sekino, H. Miyakawa, 1991, Biochemical and biophysical research communications.

Cellular localization of adenosine A1 receptors in rat forebrain: Immunohistochemical analysis using adenosine A1 receptor‐specific monoclonal antibody

Y. Sekino, L. Chen, H. Nakata, 1999, The Journal of comparative neurology.

Structural development of stabilized helical peptides as inhibitors of estrogen receptor (ER)-mediated transcription.

Y. Sekino, M. Naito, Y. Kanda, 2015, Bioorganic & medicinal chemistry.

Development of cell-penetrating R7 fragment-conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription.

Y. Sekino, M. Naito, Y. Kanda, 2014, Bioconjugate chemistry.

Selective inhibition of homosynaptic depression in a tetanized pathway by an adenosine A1 blocker in the CA1 region of rat hippocampal slice

Y. Sekino, I. Koyama, 1992, Neuroscience Letters.

8-cyclopentyltheophylline, an adenosine A1 receptor antagonist, inhibits the reversal of long-term potentiation in hippocampal CA1 neurons.

Y. Kuroda, Y. Sekino, H. Kato, 1997, European journal of pharmacology.

Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells

Y. Sekino, H. Hirai, T. Irie, 2014, The Journal of physiology.

NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells

Y. Sekino, Y. Kotake, Y. Kanda, 2014, Scientific Reports.

Cellular localization and dendritic function of rat isoforms of the SRF coactivator MKL1 in cortical neurons

T. Shirao, Y. Sekino, J. Baraban, 2014, Neuroreport.

Identification, expression and characterization of rat isoforms of the serum response factor (SRF) coactivator MKL1

T. Shirao, Y. Sekino, J. Baraban, 2013, FEBS open bio.

Role of actin cytoskeleton in dendritic spine morphogenesis

T. Shirao, Y. Sekino, N. Kojima, 2007, Neurochemistry International.

Good Cell Culture Practice for stem cells and stem-cell-derived models.

Anton Simeonov, Mardas Daneshian, Yasunari Kanda, 2016, ALTEX.

Tributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells

Y. Sekino, S. Yoshida, Y. Kanda, 2018, Scientific Reports.

Induction of Adenosine A1 Receptor Expression by Pertussis Toxin via an Adenosine 5′-Diphosphate Ribosylation-Independent Pathway

Y. Sekino, S. Pingle, D. Mukherjea, 2006, Journal of Pharmacology and Experimental Therapeutics.

Delayed signal propagation via CA2 in rat hippocampal slices revealed by optical recording.

K. Obata, M. Tanifuji, Y. Sekino, 1997, Journal of neurophysiology.

Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone

Y. Sekino, J. Goldman, Kaoru Sato, 2014, The Journal of Neuroscience.

Characterization of Functional Primary Cilia in Human Induced Pluripotent Stem Cell-Derived Neurons

T. Shirao, Y. Sekino, Noriko Koganezawa, 2019, Neurochemical Research.

Characterization of human iPS cell-derived cardiomyocyte sheets as a model to detect drug-induced conduction disturbance.

Y. Sekino, Y. Kanda, A. Sugiyama, 2017, The Journal of toxicological sciences.

L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the ‘collusion’ hypothesis for increased extracellular L-glutamate concentration in neuroinflammation

Y. Sekino, Takeshi Suzuki, Koki Fujimori, 2012, Journal of Neuroinflammation.

Expression of drebrin E in migrating neuroblasts in adult rat brain: Coincidence between drebrin E disappearance from cell body and cessation of migration

T. Shirao, Y. Sekino, N. Kojima, 2008, Neuroscience.

Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation

Y. Sekino, Y. Kanda, M. Kurihara, 2014, Nature Communications.

Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro

T. Shirao, Y. Sekino, T. Shofuda, 2021, Molecular Brain.

Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates

Y. Sekino, K. Sawamoto, N. Kaneko, 2021, Molecular brain.

High level of adenosine A1 receptor-like immunoreactivity in the CA2/CA3a region of the adult rat hippocampus

T. Shirao, Y. Sekino, M. Saji, 1999, Neuroscience.

Spikar, a novel drebrin‐binding protein, regulates the formation and stabilization of dendritic spines

T. Shirao, Y. Sekino, N. Koibuchi, 2014, Journal of neurochemistry.

Y. Sekino, Takeshi Suzuki, Koki Fujimori, 2012, Journal of Neuroinflammation.

Drebrin-Dependent Actin Clustering in Dendritic Filopodia Governs Synaptic Targeting of Postsynaptic Density-95 and Dendritic Spine Morphogenesis

T. Shirao, Y. Sekino, Hideto Takahashi, 2003, The Journal of Neuroscience.

Proarrhythmia risk prediction using human induced pluripotent stem cell-derived cardiomyocytes.

Yasunari Kanda, Atsuhiro Yamanishi, Etsushi Takahashi, 2018, Journal of pharmacological sciences.

Hyaluronan synthesis supports glutamate transporter activity

Y. Sekino, S. Yoshida, M. Yasui, 2019, Journal of neurochemistry.

Improvement of acquisition and analysis methods in multi-electrode array experiments with iPS cell-derived cardiomyocytes.

Yasunari Kanda, Kohei Sawada, Seiji Hayashi, 2015, Journal of pharmacological and toxicological methods.

Antisense knockdown of drebrin A, a dendritic spine protein, causes stronger preference, impaired pre-pulse inhibition, and an increased sensitivity to psychostimulant

T. Shirao, Y. Sekino, M. Saji, 2004, Neuroscience Research.

The role of drebrin in dendritic spines

T. Shirao, Y. Sekino, Noriko Koganezawa, 2017, Molecular and Cellular Neuroscience.

Clustering and anchoring mechanisms of molecular constituents of postsynaptic scaffolds in dendritic spines

T. Shirao, Y. Sekino, 2001, Neuroscience Research.

The effects of neurotrophin-3 and brain-derived neurotrophic factor on cerebellar granule cell movement and neurite extension in vitro

T. Shirao, Y. Sekino, Yuko Sekino, 2000, Neuroscience.

G protein‐independent neuromodulatory action of adenosine on metabotropic glutamate signalling in mouse cerebellar Purkinje cells

B. Fredholm, M. Kano, Y. Sekino, 2007, The Journal of physiology.

Comparative gene expression analysis of the amygdala in autistic rat models produced by pre- and post-natal exposures to valproic acid.

Y. Sekino, Atsuko Oguchi-Katayama, T. Moriguchi, 2013 .

Nicotine increases cancer stem cell population in MCF-7 cells.

Y. Sekino, Y. Kanda, Naoya Hirata, 2010, Biochemical and biophysical research communications.

General Introduction to Drebrin.

T. Shirao, Y. Sekino, 2017, Advances in experimental medicine and biology.

Electrophysiological Characteristics of Human iPSC-Derived Cardiomyocytes for the Assessment of Drug-Induced Proarrhythmic Potential

Y. Sekino, K. Sawada, T. Yoshinaga, 2016, PloS one.

Distribution and expression of A1 adenosine receptors, adenosine deaminase and adenosine deaminase-binding protein (CD26) in goldfish brain

Y. Sekino, U. Traversa, J. Nagy, 2003, Neurochemistry International.

Points to consider for a validation study of iPS cell-derived cardiomyocytes using a multi-electrode array system.

Yasunari Kanda, Junko Kurokawa, Daiju Yamazaki, 2016, Journal of pharmacological and toxicological methods.

Potential Application of Human iPS Cells-derived Cardiomyocytes to a New Test Method: Toward Revision of ICH S 7 B Guideline 諫田泰成,山崎大樹,関野祐子*

Y. Sekino, Y. Kanda, D. Yamazaki, 2016 .

An inhibitory pathway controlling the gating mechanism of the mouse lateral amygdala revealed by voltage-sensitive dye imaging

T. Shirao, Y. Sekino, Noriko Koganezawa, 2015, Neuroscience Letters.

The role of drebrin in neurons

T. Shirao, Y. Sekino, Noriko Koganezawa, 2017, Journal of neurochemistry.

Activation of N-methyl-d-aspartate receptor induces a shift of drebrin distribution: Disappearance from dendritic spines and appearance in dendritic shafts

Hiroyuki Yamazaki, Tomoaki Shirao, Yuko Sekino, 2006, Molecular and Cellular Neuroscience.

Three-dimensional distribution of Fos-positive neurons in the supramammillary nucleus of the rat exposed to novel environment

Makoto Ito, Kenji Doya, Tomoaki Shirao, 2009, Neuroscience Research.

Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses

C. Aoki, T. Shirao, Y. Sekino, 2005, The Journal of comparative neurology.

Role of α7-nicotinic acetylcholine receptor in normal and cancer stem cells.

Y. Sekino, Y. Kanda, Naoya Hirata, 2012, Current drug targets.

Nitric oxide serves as an endogenous regulator of neuronal adenosine A1 receptor expression

Y. Sekino, L. Toth, V. Ramkumar, 2006, Journal of neurochemistry.

Interleukin‐6‐type cytokines in neuroprotection and neuromodulation: oncostatin M, but not leukemia inhibitory factor, requires neuronal adenosine A1 receptor function

Y. Sekino, H. Boddeke, K. Biber, 2010, Journal of neurochemistry.

Myosin II ATPase Activity Mediates the Long-Term Potentiation-Induced Exodus of Stable F-Actin Bound by Drebrin A from Dendritic Spines

T. Shirao, Y. Sekino, Y. Ishizuka, 2014, PloS one.

Glypican 6 Enhances N-Methyl-D-Aspartate Receptor Function in Human-Induced Pluripotent Stem Cell-Derived Neurons

Y. Sekino, Kaoru Sato, Kanako Takahashi, 2016, Front. Cell. Neurosci..

Role of Drebrin in Synaptic Plasticity.

T. Shirao, Y. Sekino, Noriko Koganezawa, 2017, Advances in experimental medicine and biology.

Activity of the AMPA receptor regulates drebrin stabilization in dendritic spine morphogenesis

T. Shirao, Y. Sekino, Hideto Takahashi, 2009, Journal of Cell Science.

Overexpression of drebrin A in immature neurons induces the accumulation of F-actin and PSD-95 into dendritic filopodia, and the formation of large abnormal protrusions

T. Shirao, Y. Sekino, Hideto Takahashi, 2005, Molecular and Cellular Neuroscience.

Increase in AMPA receptor-mediated miniature EPSC amplitude after chronic NMDA receptor blockade in cultured hippocampal neurons

T. Shirao, Y. Sekino, H. Yasuda, 2007, Neuroscience Letters.

Upregulations of metallothionein gene expressions and tolerance to heavy metal toxicity by three dimensional cultivation of HepG2 cells on VECELL 3-D inserts.

Y. Sekino, S. Ishida, Su-ryang Kim, 2016, The Journal of toxicological sciences.

MAM-2201, a synthetic cannabinoid drug of abuse, suppresses the synaptic input to cerebellar Purkinje cells via activation of presynaptic CB1 receptors

M. Usami, Y. Sekino, Y. Goda, 2015, Neuropharmacology.

A synthetic cannabinoid MAM-2201 potently suppresses synaptic transmission via activation of presynaptic CB 1 receptors and reduces synaptically-evoked Intracellular Ca 2 þ transients in cerebellar Purkinje cells

M. Usami, Y. Sekino, Y. Goda, 2015 .

Adenosine A1 receptor antagonist-induced facilitation of postsynaptic AMPA currents in pyramidal neurons of the rat hippocampal CA2 area.

Y. Sekino, M. Kawamura, 2022, Purinergic signalling.

Design and synthesis of novel selective estrogen receptor degradation inducers based on the diphenylheptane skeleton.

M. Makishima, Y. Sekino, M. Naito, 2017, MedChemComm.

Tobacco nitrosamine NNK increases ALDH-positive cells via ROS-Wnt signaling pathway in A549 human lung cancer cells.

Y. Sekino, Y. Kanda, Naoya Hirata, 2017, The Journal of toxicological sciences.

Erratum: Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses. (Journal of Comparative Neurology (2005) 483 (383-402))

C. Aoki, T. Shirao, Y. Sekino, 2005 .

Drebrin A regulates hippocampal LTP and hippocampus-dependent fear learning in adult mice

T. Shirao, Y. Sekino, Y. Ishizuka, 2016, Neuroscience.

A novel, brain-specific mouse drebrin: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization.

T. Shirao, Y. Sekino, R. Kawai-Hirai, 2002, Genomics.

High-content imaging analysis for detecting the loss of drebrin clusters along dendrites in cultured hippocampal neurons.

T. Shirao, Y. Sekino, Noriko Koganezawa, 2019, Journal of pharmacological and toxicological methods.

An approach to elucidation of the mechanism ofinformation gating in hippocampus neural network:Lecture note of neural information science summer school NISS2003.

Yuko Sekino, Y. Sekino, 2004 .

Assessment of testing methods for drug-induced repolarization delay and arrhythmias in an iPS cell-derived cardiomyocyte sheet: multi-site validation study.

Yasunari Kanda, Kentaro Ando, Kohei Sawada, 2014, Journal of pharmacological sciences.

Imaging activity of neuronal populations with new long-wavelength voltage-sensitive dyes

George J Augustine, Leslie M Loew, Yuko Sekino, 2008, Brain cell biology.

Characterization of Functional Primary Cilia in Human Induced Pluripotent Stem Cell-Derived Neurons

T. Shirao, Y. Sekino, Noriko Koganezawa, 2019, Neurochemical Research.

Cysteamine potentiates entorhinal activation of dentate gyrus granule cells in rats

W. Abraham, Y. Sekino, A. Takazawa, 1994, Brain Research Bulletin.

A Role for Signal Propagation Through the Hippocampal CA2 Field in Memory Formation

Yuko Sekino, Tomoaki Shirao, T. Shirao, 2006, WImBI.

The sulphydryl reagent, N-ethylmaleimide, disrupts sleep and blocks A1 adenosine receptor-mediated inhibition of intracellular calcium signaling in the in vitro ventromedial preoptic nucleus

T. Shirao, Y. Sekino, M. Ikeda, 2001, Neuroscience.

Interruption of supramammillohippocampal afferents prevents the genesis and spread of limbic seizures in the hippocampus via a disinhibition mechanism

Y. Sekino, M. Saji, K. Ohno, 2000, Neuroscience.

Adenosine A2 receptor antagonist facilitates the reversal of long-term potentiation (depotentiation) of evoked postsynaptic potentials but inhibits that of population spikes in hippocampal CA1 neurons

Y. Kuroda, Y. Sekino, H. Miyakawa, 1992, Neuroscience Letters.

Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation

Y. Sekino, Y. Kanda, M. Kurihara, 2014, Nature Communications.

Suspension Culture Improves Cryopreservation- induced Damage of Liver-derived Cells

Y. Sekino, S. Ishida, T. Kanaki, 2016 .