Jiansong Sheng

发表

A temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channel.

Phu N. Tran, T. Colatsky, Zhihua Li, 2016, Journal of pharmacological and toxicological methods.

Improving the In Silico Assessment of Proarrhythmia Risk by Combining hERG (Human Ether-à-go-go-Related Gene) Channel–Drug Binding Kinetics and Multichannel Pharmacology

Kelly C. Chang, Phu N. Tran, T. Colatsky, 2017, Circulation. Arrhythmia and electrophysiology.

Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block

Phu N. Tran, D. Strauss, Jiansong Sheng, 2020, PloS one.

Drug potency on inhibiting late Na+ current is sensitive to gating modifier and current region where drug effects were measured.

Phu N. Tran, Jiansong Sheng, Wendy W Wu, 2019, Journal of pharmacological and toxicological methods.

Bisphenol S and bisphenol F are less disruptive to cardiac electrophysiology and potentially safer for use in medical products, as compared to bisphenol A

Jiansong Sheng, L. Swift, Marissa Reilly, 2021, bioRxiv.

quantification reveals the importance of data variability and experimental design considerations for in silico

Kelly C. Chang, Phu N. Tran, T. Colatsky, 2017 .

Plasticizer Interaction With the Heart

Jiansong Sheng, L. Tereshchenko, J. Saiz, 2019, Circulation. Arrhythmia and electrophysiology.

A general procedure to select calibration drugs for lab-specific validation and calibration of proarrhythmia risk prediction models: An illustrative example using the CiPA model.

James Kramer, David G Strauss, George Okeyo, 2020, Journal of pharmacological and toxicological methods.

A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm

James Kramer, David G Strauss, Liudmila Polonchuk, 2020, Toxicology and applied pharmacology.

Abstract 454: Plasticizer Interaction With the Heart: Chemicals Used in Plastic Medical Devices Can Interfere With Cardiac Electrophysiology

Jiansong Sheng, L. Swift, N. Posnack, 2019, Circulation Research.

Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative

Min Wu, James Kramer, Gary R. Mirams, 2018, Clinical pharmacology and therapeutics.

Bisphenol S and bisphenol F are less disruptive to cardiac electrophysiology, as compared to bisphenol A.

Jiansong Sheng, L. Swift, Marissa Reilly, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment

Min Wu, Zhihua Li, Gary R. Mirams, 2017, Front. Physiol..

Experimental factors that impact CaV1.2 channel pharmacology—Effects of recording temperature, charge carrier, and quantification of drug effects on the step and ramp currents elicited by the “step-step-ramp” voltage protocol

Phu N. Tran, Jiansong Sheng, Wendy W Wu, 2022, PloS one.

Characterization of loperamide-mediated block of hERG channels at physiological temperature and its proarrhythmia propensity.

Kelly C. Chang, Phu N. Tran, T. Colatsky, 2017, Journal of pharmacological and toxicological methods.

Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment

Kelly C. Chang, Phu N. Tran, T. Colatsky, 2017, Front. Physiol..