C. Brearley

发表

AtDGK2, a Novel Diacylglycerol Kinase from Arabidopsis thaliana, Phosphorylates 1-Stearoyl-2-arachidonoyl-sn-glycerol and 1,2-Dioleoyl-sn-glycerol and Exhibits Cold-inducible Gene Expression*

F. Gómez-Merino, C. Brearley, M. Ornatowska, 2004, Journal of Biological Chemistry.

Inositol hexakisphosphate is a physiological signal regulating the K+-inward rectifying conductance in guard cells.

C. Brearley, F. Lemtiri-Chlieh, E. Macrobbie, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Enhanced Transcription of the Arabidopsis Disease Resistance Genes RPW8.1 and RPW8.2 via a Salicylic Acid–Dependent Amplification Circuit Is Required for Hypersensitive Cell Death Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.006940.

C. Brearley, S. Xiao, E. Patrick, 2003, The Plant Cell Online.

Molecular dissection of bacterial acrylate catabolism--unexpected links with dimethylsulfoniopropionate catabolism and dimethyl sulfide production.

C. Brearley, J. Todd, P. C. Page, 2010, Environmental microbiology.

A role for inositol hexakisphosphate in the maintenance of basal resistance to plant pathogens.

C. Brearley, J. Carr, A. Murphy, 2008, The Plant journal : for cell and molecular biology.

Synthesis of inositol phosphate ligands of plant hormone-receptor complexes: pathways of inositol hexakisphosphate turnover.

C. Brearley, P. Green, D. Hanke, 2012, The Biochemical journal.

Effect of phytase on intestinal phytate breakdown, plasma inositol concentrations and glucose transporter type 4 abundance in muscle membranes of weanling pigs.

C. Brearley, K. Ajuwon, M. Bedford, 2019, Journal of animal science.

Reduced inositol content and altered morphology in transgenic potato plants inhibited for 1D‐myo‐inositol 3‐phosphate synthase

C. Brearley, R. Trethewey, B. Müller-röber, 1998 .

Quantum Blue Reduces the Severity of Woody Breast Myopathy via Modulation of Oxygen Homeostasis-Related Genes in Broiler Chickens

C. Brearley, S. Dridi, E. Greene, 2019, Front. Physiol..

Effects of fou8/fry1 Mutation on Sulfur Metabolism: Is Decreased Internal Sulfate the Trigger of Sulfate Starvation Response?

C. Brearley, A. Chételat, E. Farmer, 2012, PloS one.

The Arabidopsis ATP-binding Cassette Protein AtMRP5/AtABCC5 Is a High Affinity Inositol Hexakisphosphate Transporter Involved in Guard Cell Signaling and Phytate Storage*

C. Brearley, J. Schjoerring, E. Martinoia, 2009, The Journal of Biological Chemistry.

Metabolism of 3‐ and 4‐phosphorylated phosphatidylinositols in stomatal guard cells of Commelina communis L.

C. Brearley, P. N. Parmar, 1995 .

Arabidopsis inositol phosphate kinases, IPK1 and ITPK1, constitute a metabolic pathway in maintaining phosphate homeostasis

C. Brearley, T. Munnik, T. Chiou, 2018, bioRxiv.

An Arabidopsis inositol phospholipid kinase strongly expressed in procambial cells: synthesis of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 in insect cells by 5-phosphorylation of precursors.

C. Brearley, B. Mueller‐Roeber, H. Xue, 2001, The Plant journal : for cell and molecular biology.

Structure of a cereal purple acid phytase provides new insights to phytate degradation in plants

C. Brearley, A. Hemmings, H. Brinch-Pedersen, 2022, Plant communications.

Insights to the Structural Basis for the Stereospecificity of the Escherichia coli Phytase, AppA

C. Brearley, A. Hemmings, E. Thompson, 2022, International journal of molecular sciences.

Allosteric Site on SHIP2 Identified Through Fluorescent Ligand Screening and Crystallography: A Potential New Target for Intervention

A. M. Riley, C. Brearley, A. Hemmings, 2021, Journal of medicinal chemistry.

Snapshots during the catalytic cycle of a histidine acid phytase reveal an induced fit structural mechanism.

C. Brearley, A. Hemmings, M. Bedford, 2020, The Journal of biological chemistry.

An ATP-responsive metabolic cassette comprised of inositol tris/tetrakisphosphate kinase 1 (ITPK1) and inositol pentakisphosphate 2-kinase (IPK1) buffers diphosphosphoinositol phosphate levels

A. M. Riley, C. Brearley, A. Hemmings, 2020, The Biochemical journal.

A Fluorescent Probe Identifies Active Site Ligands of Inositol Pentakisphosphate 2-Kinase.

A. M. Riley, C. Brearley, A. Hemmings, 2018, Journal of medicinal chemistry.

Improved sensitivity, accuracy and prediction provided by a high‐performance liquid chromatography screen for the isolation of phytase‐harbouring organisms from environmental samples

C. Brearley, A. Neal, J. Todd, 2020, Microbial biotechnology.

Regioisomeric Family of Novel Fluorescent Substrates for SHIP2

A. M. Riley, C. Brearley, B. Potter, 2019, ACS medicinal chemistry letters.

Exogenous phytase and xylanase exhibit opposing effects on real-time gizzard pH in broiler chickens

C. Brearley, M. Bedford, S. A. Lee, 2018, British poultry science.

Nonmonotonic trends in electrolyte-induced injury to rapidly cooled erythrocytes.

C. Brearley, C. Olliff, N. Hodges, 1992, Cryobiology.

Membrane specificity of non-monotonic trends in cation-mediated injury to rapidly frozen phospholipid vesicles.

C. Brearley, N. Hodges, C. Oliff, 1991, Chemistry and physics of lipids.

The Retention of Entrapped Molecules within Erythrocyte Ghosts During Cryopreservation

C. Brearley, C. Olliff, N. Hodges, 1990, The Journal of pharmacy and pharmacology.

At 5 PTase 13 Modulates Cotyledon Vein Development through Regulating Auxin Homeostasis 1 [ W ]

C. Brearley, B. Mueller‐Roeber, H. Xue, 2005 .

At5PTase13 Modulates Cotyledon Vein Development through Regulating Auxin Homeostasis1[W]

C. Brearley, B. Mueller‐Roeber, H. Xue, 2005, Plant Physiology.

Arabidopsis inositol phosphate kinases, IPK1 and ITPK1, constitute a metabolic pathway in maintaining phosphate homeostasis

C. Brearley, T. Munnik, T. Chiou, 2018, bioRxiv.

Characterization of myo‐inositol hexakisphosphate deposits from larval Echinococcus granulosus

C. Brearley, N. Veiga, C. Fontana, 2006, The FEBS journal.

Characterisation of a soil MINPP phytase with remarkable long-term stability and activity from Acinetobacter sp.

C. Brearley, A. Hemmings, J. Todd, 2022, PloS one.

Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts.

C. Brearley, C. Whiteford, E. Ulug, 1997, The Biochemical journal.

Phytase dose-dependent response of kidney inositol phosphate levels in poultry

C. Brearley, E. Burton, D. Scholey, 2022, PloS one.

Arabidopsis thaliana inositol 1,3,4‐trisphosphate 5/6‐kinase 4 (AtITPK4) is an outlier to a family of ATP‐grasp fold proteins from Arabidopsis

C. Brearley, P. Green, D. Sweetman, 2007, FEBS letters.

Manipulation of plasma myo‐inositol in broiler chickens: effect on growth performance, dietary energy, nutrient availability, and hepatic function

C. Brearley, V. Pirgozliev, S. Mansbridge, 2019, Poultry science.

Rapeseed meal processing and dietary enzymes modulate excreta inositol phosphate profile, nutrient availability, and production performance of broiler chickens

C. Brearley, M. Bedford, V. Pirgozliev, 2022, Poultry science.

Characterization of an Arabidopsis inositol 1,3,4,5,6-pentakisphosphate 2-kinase (AtIPK1).

C. Brearley, D. Hanke, D. Sweetman, 2006, The Biochemical journal.

Pathway of synthesis of 3,4- and 4,5-phosphorylated phosphatidylinositols in the duckweed Spirodela polyrhiza L.

C. Brearley, D. Hanke, 1993, The Biochemical journal.

Lab-scale preparation and QC of phytase assay substrate from rice bran

C. Brearley, H. Brinch-Pedersen, C. Madsen, 2019, Analytical biochemistry.

Assessment of iron bioavailability from different bread making processes using an in vitro intestinal cell model

P. Shewry, C. Brearley, S. Fairweather-Tait, 2017, Food chemistry.

A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut

C. Brearley, P. Bailey, A. Hemmings, 2014, Cell reports.

Evidence for a SAL1-PAP Chloroplast Retrograde Pathway That Functions in Drought and High Light Signaling in Arabidopsis[C][W][OA]

Markus Wirtz, Peter A. Crisp, James Whelan, 2011, Plant Cell.

Intrinsic GTPase activity of a bacterial twin‐arginine translocation proofreading chaperone induced by domain swapping

C. Brearley, F. Sargent, David Guymer, 2010, The FEBS journal.

Simple synthesis of 32P-labelled inositol hexakisphosphates for study of phosphate transformations

A. M. Riley, C. Brearley, H. Y. Godage, 2017, Plant and Soil.

Land‐use influences phosphatase gene microdiversity in soils

C. Brearley, P. Hirsch, I. Clark, 2017, Environmental microbiology.

Cephalosporinases associated with outer membrane vesicles released by Bacteroides spp. protect gut pathogens and commensals against β-lactam antibiotics

C. Brearley, D. Livermore, S. Carding, 2014, The Journal of antimicrobial chemotherapy.

A Single Streptomyces Symbiont Makes Multiple Antifungals to Support the Fungus Farming Ant Acromyrmex octospinosus

Douglas W. Yu, C. Brearley, M. Hutchings, 2011, PloS one.

Phosphoinositides in Barley (Hordeum vulgare L.) Aleurone Tissue

C. Brearley, D. Hanke, 1994, Plant physiology.

Both d- and l-Glucose Polyphosphates Mimic d-myo-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins(1,4,5)P3 Receptor

A. M. Riley, C. Brearley, B. Potter, 2020, Journal of medicinal chemistry.

Bacteria are important dimethylsulfoniopropionate producers in coastal sediments

C. Brearley, L. Spurgin, Xiaohua Zhang, 2019, Nature Microbiology.

A Role of Arabidopsis Inositol Polyphosphate Kinase, AtIPK2α, in Pollen Germination and Root Growth1

C. Brearley, B. Mueller‐Roeber, H. Xue, 2005, Plant Physiology.

Arabidopsis Inositol Polyphosphate 6-/3-Kinase Is a Nuclear Protein That Complements a Yeast Mutant Lacking a Functional ArgR-Mcm1 Transcription Complex Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.006676.

C. Brearley, B. Mueller‐Roeber, H. Fromm, 2003, The Plant Cell Online.

PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase

C. Brearley, M. Schell, H. Murer, 1999, FEBS letters.

Arabidopsis AtDGK7, the Smallest Member of Plant Diacylglycerol Kinases (DGKs), Displays Unique Biochemical Features and Saturates at Low Substrate Concentration

F. Gómez-Merino, C. Brearley, B. Mueller‐Roeber, 2005, Journal of Biological Chemistry.

Effect of phytase supplementation on plasma and organ myo-inositol content and erythrocyte inositol phosphates as pertaining to breast meat quality issues in chickens

C. Brearley, S. Dridi, M. Bedford, 2022, Journal of Applied Animal Nutrition.

Jasmonate and Phytochrome A Signaling in Arabidopsis Wound and Shade Responses Are Integrated through JAZ1 Stability[C][W]

C. Brearley, C. Wasternack, H. Okamoto, 2010, Plant Cell.

A defective ABC transporter of the MRP family, responsible for the bean lpa1 mutation, affects the regulation of the phytic acid pathway, reduces seed myo-inositol and alters ABA sensitivity.

C. Brearley, E. Cassani, R. Pilu, 2011, The New phytologist.

Inositol hexakisphosphate mobilizes an endomembrane store of calcium in guard cells

A. Webb, C. Brearley, G. Prestwich, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Inositol 1,3,4,5,6-pentakisphosphate 2-kinase is a distant IPK member with a singular inositide binding site for axial 2-OH recognition

Beatriz González, Maider Villate, C. Brearley, 2010, Proceedings of the National Academy of Sciences.

Metabolic relations of inositol 3,4,5,6-tetrakisphosphate revealed by cell permeabilization. Identification of inositol 3,4,5, 6-tetrakisphosphate 1-kinase and inositol 3,4,5,6-tetrakisphosphate phosphatase activities in mesophyll cells.

C. Brearley, D. Hanke, Charles A. Brearley, 2000, Plant physiology.

Metabolic evidence for the order of addition of individual phosphate esters in the myo-inositol moiety of inositol hexakisphosphate in the duckweed Spirodela polyrhiza L.

C. Brearley, D. Hanke, 1996, The Biochemical journal.

Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlier AtITPK4

A. M. Riley, C. Brearley, A. Hemmings, 2023, The Biochemical journal.

Inhibition of membrane damage due to phospholipase activity during fractionation of wheat aleurone tissue

C. Brearley, D. L. Laidman, M. Wilkinson, 1987 .

Characterization of Arabidopsis mur3 mutations that result in constitutive activation of defence in petioles, but not leaves.

Jonathan D. G. Jones, C. Brearley, G. Fabro, 2008, The Plant journal : for cell and molecular biology.

Conformational Changes in Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase upon Substrate Binding

C. Brearley, B. González, J. Sanz-Aparicio, 2012, The Journal of Biological Chemistry.

Crystallization and preliminary X-ray diffraction analysis of inositol 1,3,4,5,6-pentakisphosphate kinase from Arabidopsis thaliana.

C. Brearley, B. González, J. Sanz-Aparicio, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Inositol phosphates in barley (Hordeum vulgare L.) aleurone tissue are stereochemically similar to the products of breakdown of InsP6 in vitro by wheat-bran phytase.

C. Brearley, D. Hanke, 1996, The Biochemical journal.

Inositol phosphates in the duckweed Spirodela polyrhiza L.

C. Brearley, D. Hanke, 1996, The Biochemical journal.

Metabolic evidence for PtdIns(4,5)P2-directed phospholipase C in permeabilized plant protoplasts.

C. Brearley, D. Hanke, P. N. Parmar, 1997, The Biochemical journal.

Molecular genetic analysis of a dimethylsulfoniopropionate lyase that liberates the climate-changing gas dimethylsulfide in several marine alpha-proteobacteria and Rhodobacter sphaeroides.

C. Brearley, J. Todd, A. Johnston, 2008, Environmental microbiology.

Snapshots during the catalytic cycle of a histidine acid phytase reveal an induced-fit structural mechanism

C. Brearley, A. Hemmings, M. Bedford, 2020, The Journal of biological chemistry.

A lysine accumulation phenotype of ScIpk2Delta mutant yeast is rescued by Solanum tuberosum inositol phosphate multikinase.

C. Brearley, Samuel E K Caddick, Christopher J. Harrison, 2007, The Biochemical journal.

Identification of 3‐ and 4‐phosphorylated phosphoinositides and inositol phosphates in stomatal guard cells

C. Brearley, P. N. Parmar, 1993 .

A Plant 126-kDa Phosphatidylinositol 4-Kinase with a Novel Repeat Structure

C. Brearley, H. Xue, C. Pical, 1999, The Journal of Biological Chemistry.

The effect of high phytase doses on phytate degradation and myo-inositol release in the grower pig

C. Brearley, S. Laird, Hm Miller, 2016 .

Platelet Shape Change Evoked by Selective Activation of P2X1 Purinoceptors with α,β-Methylene ATP

C. Brearley, M. Rolf, M. Mahaut-Smith, 2001, Thrombosis and Haemostasis.

A major role for P2X1 receptors in the early collagen-evoked intracellular Ca2+ responses of human platelets

C Y Eleanor Fung, Charles A Brearley, Richard W Farndale, 2005, Thrombosis and Haemostasis.

Platelet shape change evoked by selective activation of P2X1 purinoceptors with alpha,beta-methylene ATP.

C. Brearley, M. Rolf, M. Mahaut-Smith, 2001, Thrombosis and haemostasis.

The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function

C. Brearley, B. González, J. Sanz-Aparicio, 2017, The Journal of Biological Chemistry.

Gibberellin modulation of phosphatidyl-choline turnover in wheat aleurone tissue

C. Brearley, D. Vakharia, D. L. Laidman, 1987, Planta.

A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut

C. Brearley, P. Bailey, A. Hemmings, 2014, Cell Reports.

Accentuating the positive and eliminating the negative: Efficacy of TiO2 as digestibility index marker for poultry nutrition studies

C. Brearley, E. Burton, D. Scholey, 2023, PloS one.

Bacteria are important dimethylsulfoniopropionate producers in coastal sediments

Lewis G. Spurgin, C. Brearley, Xiaohua Zhang, 2019, Nature Microbiology.

Expression, purification, crystallization and preliminary X-ray diffraction analysis of the apo form of InsP5 2-K from Arabidopsis thaliana.

C. Brearley, B. González, J. Sanz-Aparicio, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Synthesis of inositol phosphate ligands of plant hormone-receptor complexes: pathways of inositol hexakisphosphate turnover.

C. Brearley, P. Green, D. Hanke, 2012, The Biochemical journal.

A defective ABC transporter of the MRP family, responsible for the bean lpa1 mutation, affects the regulation of the phytic acid pathway, reduces seed myo-inositol and alters ABA sensitivity.

C. Brearley, E. Cassani, R. Pilu, 2011, The New phytologist.

Inositol 1,3,4,5,6-pentakisphosphate 2-kinase is a distant IPK member with a singular inositide binding site for axial 2-OH recognition

C. Brearley, B. González, J. Sanz-Aparicio, 2010, Proceedings of the National Academy of Sciences.

A Solanum tuberosum inositol phosphate kinase (StITPK1) displaying inositol phosphate–inositol phosphate and inositol phosphate–ADP phosphotransferase activities

C. Brearley, A. Hemmings, Jennifer L. Mitchell, 2008, FEBS letters.