K. Sakaguchi

发表

HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation.

R. Henderson, H. Michel, K. Sakaguchi, 1992, Science.

High-resolution structure of the oligomerization domain of p53 by multidimensional NMR.

A. Gronenborn, G. Clore, H. Sakamoto, 1994, Science.

Refined solution structure of the oligomerization domain of the tumour suppressor p53

G. Marius Clore, James G. Omichinski, Angela M. Gronenborn, 1995, Nature Structural Biology.

The P53 Tumor Suppressor Protein

A. Gronenborn, G. Clore, H. Sakamoto, 1995 .

DNA damage activates p53 through a phosphorylation-acetylation cascade.

K. Sakaguchi, E. Appella, M. Bustin, 1998, Genes & development.

Phosphorylation of p53: a Novel Pathway for p53 Inactivation in Human T-Cell Lymphotropic Virus Type 1-Transformed Cells

Ettore Appella, K. Sakaguchi, E. Appella, 1998, Journal of Virology.

Damage-mediated Phosphorylation of Human p53 Threonine 18 through a Cascade Mediated by a Casein 1-like Kinase

K. Sakaguchi, E. Appella, C. Anderson, 2000, The Journal of Biological Chemistry.

DNA damage induces phosphorylation of the amino terminus of p53.

Y Taya, K. Sakaguchi, E. Appella, 1997, Genes & development.

The human DNA-activated protein kinase, DNA-PK: Substrate specificity

K. Sakaguchi, E. Appella, M. Connelly, 1995 .

Interhelical angles in the solution structure of the oligomerization domain of p53: correction

A M Gronenborn, G M Clore, A. Gronenborn, 1995, Science.

Preferential binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domain.

C. Harris, K. Sakaguchi, E. Appella, 1999, Journal of molecular biology.

Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53.

M. Fiscella, K. Sakaguchi, E. Appella, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Oxidation of methionine residue at hydrophobic core destabilizes p53 tetrameric structure.

K. Sakaguchi, T. Nomura, Rui Kamada, 2009, Biopolymers.

Chemical synthesis of phosphorylated peptides of the carboxy-terminal domain of human p53 by a segment condensation method.

H. Sakamoto, K. Sakaguchi, E. Appella, 2009, International journal of peptide and protein research.

Differential recognition of phosphorylated transactivation domains of p53 by different p300 domains.

K. Sakaguchi, T. Kundu, Siddhartha Roy, 2008, Journal of molecular biology.

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner.

M. Fiscella, K. Sakaguchi, E. Appella, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.

Y Taya, K. Sakaguchi, E. Appella, 1998, Science.

Synthesis of Bimetallic PdAg Nanoparticles through an Oligomerization- Controlled Biomineralization Peptide

K. Sakaguchi, J. Janairo, 2018, Materials Science Forum.

Effects of biomineralization peptide topology on the structure and catalytic activity of Pd nanomaterials.

K. Sakaguchi, K. Hara, J. Janairo, 2014, Chemical communications.

Effects of Buffer on the Structure and Catalytic Activity of Palladium Nanomaterials Formed by Biomineralization

K. Sakaguchi, J. Janairo, 2014 .

Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry.

R. Henderson, H. Michel, K. Sakaguchi, 1992, Science.

Identification of gel‐separated tumor marker proteins by mass spectrometry

M. Waltham, K. Sakaguchi, E. Appella, 2000, Electrophoresis.

High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1.

A M Gronenborn, G M Clore, A. Gronenborn, 1992, Biochemistry.

Formation of Functionalized Nanowires by Control of Self‐Assembly Using Multiple Modified Amyloid Peptides

K. Sakaguchi, Y. Chuman, K. Uosaki, 2013 .

New evidence for ATP binding induced catalytic subunit interactions in pig kidney Na/K-ATPase.

K. Sakaguchi, Kan Tanoue, K. Abe, 2006, Journal of biochemistry.

Evidence for a relationship between activity and the tetraprotomeric assembly of solubilized pig gastric H/K-ATPase.

K. Sakaguchi, K. Oiwa, K. Abe, 2005, Journal of biochemistry.

MPSA short communications

W. E. Moddeman, J. A. Lindquist, D. N. Perkins, 1988 .

DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

P. Jeggo, G. Wahl, K. Sakaguchi, 1999, Nature.

Probing phenylalanine environments in oligomeric structures with pentafluorophenylalanine and cyclohexylalanine.

K. Sakaguchi, T. Nomura, Rui Kamada, 2011, Biopolymers.

Effective Cellular Morphology Analysis for Differentiation Processes by a Fluorescent 1,3a,6a-Triazapentalene Derivative Probe in Live Cells

K. Sakaguchi, Rui Kamada, Y. Chuman, 2016, PloS one.

The ezrin-like family of tyrosine kinase substrates: receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation.

K. Sakaguchi, E. Appella, S. Ullrich, 1993, Oncogene.

Mutational analysis of Lck in CD45-negative T cells: dominant role of tyrosine 394 phosphorylation in kinase activity

K. Sakaguchi, E. Appella, J. Ashwell, 1996, Molecular and cellular biology.

The peripheral subunit-binding domain of the dihydrolipoyl acetyltransferase component of the pyruvate dehydrogenase complex of Bacillus stearothermophilus: preparation and characterization of its binding to the dihydrolipoyl dehydrogenase component.

K. Sakaguchi, E. Appella, M. Allen, 1994, The Biochemical journal.

Human p53 Is Phosphorylated on Serines 6 and 9 in Response to DNA Damage-inducing Agents*

K. Sakaguchi, E. Appella, C. Anderson, 2000, The Journal of Biological Chemistry.

Keratanase II‐Catalyzed Synthesis of Keratan Sulfate Oligomers by Using Sugar Oxazolines as Transition‐State Analogue Substrate Monomers: A Novel Insight into the Enzymatic Catalysis Mechanism

K. Sakaguchi, Shiro Kobayashi, M. Ohmae, 2007, Chembiochem : a European journal of chemical biology.

Potent immunogenic short linear peptide constructs composed of B cell epitopes and Pan DR T helper epitopes (PADRE) for antibody responses in vivo.

S. Hoffman, H. Grey, A. Sette, 1997, Vaccine.

Direct identification of an endogenous peptide recognized by multiple HLA-A2.1-specific cytotoxic T cells.

R. Henderson, K. Sakaguchi, J. Shabanowitz, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Antiproliferative Activity of Silver Nanoplates on Human Promyelocytic Leukemia Cell Lines

K. Sakaguchi, Rui Kamada, Tatsuya Sakaguchi, 2015 .

Formation process and solvent-dependent structure of a polyproline self-assembled monolayer on a gold surface.

K. Sakaguchi, K. Uosaki, H. Noguchi, 2011, Langmuir : the ACS journal of surfaces and colloids.

Proteome mapping by two-dimensional polyacrylamide gel electrophoresis in combination with mass spectrometric protein sequence analysis.

K. Sakaguchi, E. Appella, D. Arnott, 2000, EXS.

Increased expression of α‐enolase in c‐jun transformed rat fibroblasts without increased activation of plasminogen

K. Sakaguchi, E. Appella, H. Jörnvall, 1997, FEBS letters.

The proteolytic environment involved in MHC class II-restricted antigen presentation can be modulated by the p41 form of invariant chain.

K. Sakaguchi, E. Appella, J. Miller, 1996, Journal of immunology.

Identification of new melanoma epitopes on melanosomal proteins recognized by tumor infiltrating T lymphocytes restricted by HLA-A1, -A2, and -A3 alleles.

K. Sakaguchi, E. Appella, S. Rosenberg, 1998, Journal of immunology.

HLA-A 1 ,-A 2 , andA 3 Alleles Infiltrating T Lymphocytes Restricted by Melanosomal Proteins Recognized by Tumor Identification of New Melanoma Epitopes on Sakaguchi

K. Sakaguchi, E. Appella, S. Rosenberg, 1998 .

Identification of subdominant CTL epitopes of the GP100 melanoma-associated tumor antigen by primary in vitro immunization with peptide-pulsed dendritic cells.

J. Sidney, A. Sette, K. Sakaguchi, 1997, Journal of immunology.

Dimerization of neurokinin A and B COOH-terminal heptapeptide fragments enhanced the selectivity for tachykinin receptor subtypes.

K. Sakaguchi, Y. Shimohigashi, H. Kodama, 1988, European journal of pharmacology.

The Role of HSP90 in Tumor Specific Immunity

K. Sakaguchi, E. Appella, S. Ullrich, 1991 .

Patterning nanofibrils through the templated growth of multiple modified amyloid peptides

K. Sakaguchi, Rui Kamada, Y. Chuman, 2016, Scientific Reports.

CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases.

K. Sakaguchi, E. Appella, J. Ashwell, 1994, The Journal of biological chemistry.

Inhibition of tumor suppressor protein p53-dependent transcription by a tetramerization domain peptide via hetero-oligomerization.

K. Sakaguchi, Rui Kamada, Y. Chuman, 2012, Bioorganic & medicinal chemistry letters.

Zinc controls PML nuclear body formation through regulation of a paralog specific auto-inhibition in SUMO1

K. Sakaguchi, G. Ferbeyre, J. Omichinski, 2022, Nucleic acids research.

Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes.

K. Sakaguchi, E. Appella, S. Rosenberg, 1995, Journal of immunology.

Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression.

A. Sette, K. Sakaguchi, E. Appella, 1995, Journal of immunology.

Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes.

K. Sakaguchi, E. Appella, S. Rosenberg, 1995, Journal of immunology.

Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad.

A Sette, H. Grey, A. Sette, 1992, Science.

Development of a fluorescence reporter system to quantify transcriptional activity of endogenous p53 in living cells

K. Sakaguchi, Rui Kamada, T. Imagawa, 2022, bioRxiv.

Effects of mutations on tetramer formation of tumor suppressor protein p53

A. Gronenborn, G. Clore, K. Sakaguchi, 1999 .

Two-dimensional nuclear magnetic resonance analysis of a labeled peptide bound to a class II major histocompatibility complex molecule.

K. Sakaguchi, J. Altman, M. Davis, 1993, Journal of molecular biology.

The 61st Annual Meeting of the Japan Endocrine Society Invited Lecture Familial Multiple Endocrine Neoplasia Type I:Familial Multiple Endorcrine Neoplasia Type 1

K. Sakaguchi, M. Zimering, 1988 .

Self peptide requirement for class II major histocompatibility complex allorecognition.

H. Grey, A. Sette, K. Sakaguchi, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Lipid Droplet Formation Is Regulated by Ser/Thr Phosphatase PPM1D via Dephosphorylation of Perilipin 1

K. Sakaguchi, Rui Kamada, Nozomi Kimura, 2022, International journal of molecular sciences.

Discussion of the Paper

G. Clore, K. Sakaguchi, E. Appella, 1994 .

Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family.

J. Coligan, K. Sakaguchi, E. Appella, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Zinc Fingers Involved in MHC Class I Gene Regulation: Use of Synthetic Peptides for Structural Analysis

A. Gronenborn, G. Clore, K. Sakaguchi, 1991 .

Thymocyte costimulating antigen is CD26 (dipeptidyl-peptidase IV). Costimulation of granulocyte, macrophage, and T lineage cell proliferation via CD26.

K. Sakaguchi, E. Appella, L. Bristol, 1992, Journal of immunology.

Effects of E/Z Configuration of Fluoroalkene-containing HDAC Inhibitors on Selectivity for HDAC Isoforms

K. Sakaguchi, Y. Chuman, Fei-Yue Wu, 2013 .

Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor.

K. Sakaguchi, J. Zhang, R. Siraganian, 1997, Journal of immunology.

Optimum Cross-linking Spacer Length of Dimeric Neurokinin B Analogs for Interaction with NK-1 Tachykinin Receptors.

K. Sakaguchi, Y. Shimohigashi, M. Ohno, 1993 .

Colocalization of heparin and receptor binding sites on keratinocyte growth factor.

H. Sakamoto, K. Sakaguchi, R. Day, 1998, Biochemistry.

Development of a fluorescence reporter system to quantify transcriptional activity of endogenous p53 in living cells

K. Sakaguchi, Rui Kamada, T. Imagawa, 2022, bioRxiv.

Specific sequences from the carboxyl terminus of human p53 gene product form anti-parallel tetramers in solution.

H. Sakamoto, K. Sakaguchi, E. Appella, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Phosphorylation of human p53 by p38 kinase coordinates N‐terminal phosphorylation and apoptosis in response to UV radiation

K. Sakaguchi, E. Appella, A. Fornace, 1999, The EMBO journal.

Structural requirements of nociceptin antagonist Ac‐RYYRIK‐NH2 for receptor binding

K. Sakaguchi, Y. Shimohigashi, K. Okada, 2002, Journal of peptide science : an official publication of the European Peptide Society.

Fluoroalkene modification of mercaptoacetamide-based histone deacetylase inhibitors.

K. Sakaguchi, Y. Chuman, H. Kodama, 2010, Bioorganic & medicinal chemistry.

Identification of a binding site for the human immunodeficiency virus type 1 nucleocapsid protein.

A. Gronenborn, G. Clore, K. Sakaguchi, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of tachykinin receptors in endothelial cells of porcine artery

K. Sakaguchi, Y. Shimohigashi, H. Kamiya, 1990, Neuroscience Letters.

Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors.

K. Sakaguchi, S. Ito, J. Omichinski, 2020, Pharmacology & therapeutics.

PPM1D controls nucleolar formation by up-regulating phosphorylation of nucleophosmin

K. Sakaguchi, Rui Kamada, Y. Chuman, 2016, Scientific Reports.

Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes

K. Sakaguchi, E. Appella, S. Rosenberg, 1994, The Journal of experimental medicine.

An efficient and cost-effective isotope labeling protocol for proteins expressed in shape Escherichia coli

G M Clore, A. Gronenborn, G. Clore, 1998, Journal of biomolecular NMR.

Calreticulin and calreticulin fragments are endothelial cell inhibitors that suppress tumor growth.

K. Sakaguchi, E. Appella, J. Teruya-Feldstein, 1999, Blood.

Structural characterization of a 39‐residue synthetic peptide containing the two zinc binding domains from the HIV‐1 p7 nucleocapsid protein by CD and NMR spectroscopy

A. Gronenborn, G. Clore, K. Sakaguchi, 1993 .

Structural characterization of a 39-residue synthetic peptide containing the two zinc binding domains from the HIV-1 p7 nucleocapsid protein by CD and NMR spectroscopy.

A. Gronenborn, G. Clore, K. Sakaguchi, 1991, FEBS letters.

Heparan sulfate proteoglycan modulates keratinocyte growth factor signaling through interaction with both ligand and receptor.

K. Sakaguchi, Y. Takagi, R. Day, 1999, Biochemistry.

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53

K. Sakaguchi, E. Appella, C. Anderson, 1992, Molecular and cellular biology.

Interferon stimulation creates chromatin marks and establishes transcriptional memory

K. Sakaguchi, K. Ozato, Jun Zhu, 2018, Proceedings of the National Academy of Sciences.

Heterochiral Jun and Fos bZIP peptides form a coiled‐coil heterodimer that is competent for DNA binding

K. Sakaguchi, Rui Kamada, Taiji Oyama, 2017, Journal of peptide science : an official publication of the European Peptide Society.

Analysis of MHC-Specific Peptide Motifs

A. Sette, K. Sakaguchi, E. Appella, 1995 .

Structural isoforms of the circadian neuropeptide PDF expressed in the optic lobes of the cricket Gryllus bimaculatus: Immunocytochemical evidence from specific monoclonal antibodies

I. Meinertzhagen, K. Sakaguchi, Y. Chuman, 2006, The Journal of comparative neurology.

Specific Acetylation of Chromosomal Protein HMG-17 by PCAF Alters Its Interaction with Nucleosomes

K. Sakaguchi, M. Bustin, Y. Nakatani, 1999, Molecular and Cellular Biology.

PPM1D is a neuroblastoma oncogene and therapeutic target in childhood neural tumors

D. Gisselsson, M. Kool, K. Sakaguchi, 2020, bioRxiv.

Thr-774 (Transmembrane Segment M5), Val-920 (M8), and Glu-954 (M9) Are Involved in Na+ Transport, and Gln-923 (M8) Is Essential for Na,K-ATPase Activity*

K. Sakaguchi, S. Kaya, T. Imagawa, 2005, Journal of Biological Chemistry.

Tetramer formation of tumor suppressor protein p53: Structure, function, and applications

K. Sakaguchi, Rui Kamada, Y. Toguchi, 2016, Biopolymers.

Cancer-associated p53 Tetramerization Domain Mutants

K. Sakaguchi, C. Anderson, Rui Kamada, 2010, The Journal of Biological Chemistry.

Lower DNA methylation levels in CpG island shores of CR1, CLU, and PICALM in the blood of Japanese Alzheimer’s disease patients

K. Ozaki, K. Sakaguchi, S. Niida, 2020, PloS one.

Lower DNA methylation levels in CpG island shores of CR1, CLU, and PICALM genes in the blood of Alzheimer's disease patients

K. Sakaguchi, S. Niida, N. Shimoda, 2020, medRxiv.

Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.

K. Sakaguchi, E. Appella, S. Rosenberg, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas

K. Sakaguchi, E. Appella, H. Jörnvall, 1999, FEBS letters.

Receptor Interactions of Synthetic Morphiceptin Analogs Containing Phenylalanine Homologs in Position 4

H. Sakamoto, K. Sakaguchi, Y. Shimohigashi, 1992 .

Opioid Activities of Morphiceptin Analogs Derived from Human β-Casein

H. Sakamoto, K. Sakaguchi, Y. Shimohigashi, 1990 .

Vasostatin, a Calreticulin Fragment, Inhibits Angiogenesis and Suppresses Tumor Growth

K. Sakaguchi, E. Appella, J. Teruya-Feldstein, 1998, The Journal of experimental medicine.

Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition with the Neighboring Normal Epithelial Cells.

K. Sakaguchi, S. Yonezawa, Yasuyuki Fujita, 2018, Cell reports.

Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant.

S. Ceman, A. Sette, H. Michel, 1992, Science.

SMAR1 forms a ternary complex with p53-MDM2 and negatively regulates p53-mediated transcription.

K. Sakaguchi, S. Chattopadhyay, Siddhartha Roy, 2009, Journal of molecular biology.

Site-directed affinity-labeling of delta opioid receptors by SNpys-containing enkephalin and dynorphin analogues

K. Sakaguchi, Y. Shimohigashi, K. Okada, 2003, Letters in Peptide Science.

Site-directed affinity-labeling of delta opioid receptors by

K. Sakaguchi, Y. Shimohigashi, K. Okada, 2003, Letters in Peptide Science.

Unfolding, aggregation, and amyloid formation by the tetramerization domain from mutant p53 associated with lung cancer.

Kohei Uosaki, Ettore Appella, S. Durell, 2006, Biochemistry.

Dilation of the Human Immunodeficiency Virus–1 Envelope Glycoprotein Fusion Pore Revealed by the Inhibitory Action of a Synthetic Peptide from gp41

S. Durell, K. Sakaguchi, E. Appella, 1998, The Journal of cell biology.

Clonality of parathyroid tumors in familial multiple endocrine neoplasia type 1.

Y. Nakamura, K. Sakaguchi, E. Friedman, 1989, The New England journal of medicine.

Induction of tumor-reactive CTL from peripheral blood and tumor-infiltrating lymphocytes of melanoma patients by in vitro stimulation with an immunodominant peptide of the human melanoma antigen MART-1.

A Sette, F. Marincola, A. Sette, 1995, Journal of immunology.

Familial multiple endocrine neoplasia type I.

K. Sakaguchi, M. Brandi, S. Marx, 1988, Nihon Naibunpi Gakkai zasshi.

Linkage analysis of multiple endocrine neoplasia type 1 with INT2 and other markers on chromosome 11.

K. Sakaguchi, S. Bale, M. Brandi, 1989, Genomics.

Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element

T. Golub, K. Sakaguchi, E. Appella, 2002, Molecular and Cellular Biology.

Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53.

H. Sakamoto, K. Sakaguchi, E. Appella, 1997, Biochemistry.

Definition of a DQ3.1-specific binding motif.

M F del Guercio, C Oseroff, A Sette, 1994, Journal of immunology.

Characteristics of endogenous peptides eluted from the class I MHC molecule HLA-B7 determined by mass spectrometry and computer modeling.

R. Henderson, K. Sakaguchi, J. Shabanowitz, 1993, Journal of immunology.

Structural and functional characterization of the phosphorylation-dependent interaction between PML and SUMO1.

K. Sakaguchi, G. Ferbeyre, J. Omichinski, 2015, Structure.

Eph receptorsandephrins restrict cell intermingling andcommunication

G. Wahl, K. Sakaguchi, M. Hubank, 1999 .

A small molecule inhibitor of p53-inducible protein phosphatase PPM1D.

K. Sakaguchi, Y. Chuman, T. Imagawa, 2012, Bioorganic & medicinal chemistry letters.

Three-dimensional solution structure of the E3-binding domain of the dihydrolipoamide succinyltransferase core from the 2-oxoglutarate dehydrogenase multienzyme complex of Escherichia coli.

A. Gronenborn, G. Clore, K. Sakaguchi, 1994, Biochemistry.

Characterization of a new cancer-associated mutant of p53 with a missense mutation (K351N) in the tetramerization domain

K. Sakaguchi, L. Tuosto, G. Blandino, 2009, Cell cycle.

PPM1D430, a novel alternative splicing variant of the human PPM1D, can dephosphorylate p53 and exhibits specific tissue expression.

K. Sakaguchi, Y. Chuman, Y. Mizukami, 2008, Journal of biochemistry.

Definition of specific peptide motifs for four major HLA-A alleles.

A Sette, H. Grey, A. Sette, 1994, Journal of immunology.

Antibodies to macrophage stimulating protein (MSP): specificity, epitope interactions, and immunoassay of MSP in human serum

K. Sakaguchi, E. Leonard, Ming-Hai Wang, 1993, Journal of leukocyte biology.

PPM1D Is a Therapeutic Target in Childhood Neural Tumors

K. Sakaguchi, P. Kogner, J. Johnsen, 2021, Cancers.

Mitogenic activity on parathyroid cells in plasma from members of a large kindred with multiple endocrine neoplasia type 1.

K. Sakaguchi, M. Brandi, K. Sakaguchi, 1988, The Journal of clinical endocrinology and metabolism.

Naturally processed peptides longer than nine amino acid residues bind to the class I MHC molecule HLA-A2.1 with high affinity and in different conformations.

A Sette, J Sidney, J. Sidney, 1994, Journal of immunology.

Quantitative Correlation between the Protein Expression Level in Escherichia Coli and Thermodynamic Stability of Protein In Vitro

K. Sakaguchi, Rui Kamada, H. Miyazaki, 2016 .

Ribosomal protein uL30 undergoes phase separation with nucleophosmin and regulates nucleolar formation in the absence of RNA.

K. Sakaguchi, Rui Kamada, J. Janairo, 2022, Biochemical and biophysical research communications.

Autoreactive cytotoxic T lymphocytes in human immunodeficiency virus type 1-infected subjects

A. Sette, K. Sakaguchi, J. Shabanowitz, 1996, The Journal of experimental medicine.

Peripheral T cell response to A-gliadin in celiac disease: differential processing and presentation capacities of Epstein-Barr-transformed B cells and fibroblasts.

H. Grey, A. Sette, K. Sakaguchi, 1994, Clinical immunology and immunopathology.

Pillars article: Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. Science 1992. 255: 1261-1263.

R. Henderson, H. Michel, K. Sakaguchi, 2007, Journal of immunology.

Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes

K. Sakaguchi, E. Appella, S. Rosenberg, 1994, The Journal of experimental medicine.

Chemical synthesis and applications of phosphopeptides.

K. Sakaguchi, E. Appella, P. Roller, 1996, Genetic engineering.

Calcium-dependent Interaction of S100B with the C-terminal Domain of the Tumor Suppressor p53*

K. Sakaguchi, L. Debussche, C. Delphin, 1999, The Journal of Biological Chemistry.

Wip 1 , a novel human protein phosphatase that is induced in response to ionizing radiation in a p 53-dependent manner

M. Fiscella, W., K. Sakaguchi, 1997 .

Phosphatase assay for multi-phosphorylated substrates using phosphatase specific-motif antibody.

K. Sakaguchi, Y. Chuman, Y. Shimohigashi, 2011, Journal of biochemistry.

Sequence analysis of peptides presented to the immune system by class I and class II MHC molecules

H. Grey, A. Sette, R. Henderson, 1992 .

Posttranslational modifications involved in the DNA damage response.

K. Sakaguchi, E. Appella, C. Anderson, 1998, Journal of protein chemistry.

Inhibition of protein phosphatase PPM1D enhances retinoic acid-induced differentiation in human embryonic carcinoma cell line.

K. Sakaguchi, Rui Kamada, Y. Chuman, 2019, Journal of biochemistry.

Enhancement of transcriptional activity of mutant p53 tumor suppressor protein through stabilization of tetramer formation by calix[6]arene derivatives.

K. Sakaguchi, Rui Kamada, Y. Chuman, 2010, Bioorganic & medicinal chemistry letters.

Evaluation of transcriptional activity of p53 in individual living mammalian cells.

K. Sakaguchi, Rui Kamada, T. Imagawa, 2009, Analytical biochemistry.

Specific DNA binding to a major histocompatibility complex enhancer sequence by a synthetic 57-residue double zinc finger peptide from a human enhancer binding protein.

A. Gronenborn, G. Clore, K. Sakaguchi, 1991, The Journal of biological chemistry.

Design of Potent Inhibitors of Human RAD51 Recombinase Based on BRC Motifs of BRCA2 Protein: Modeling and Experimental Validation of a Chimera Peptide

Vinh Tran, Andrzej Stasiak, K. Sakaguchi, 2010, Journal of medicinal chemistry.

Structural Essentials of Ser-1 in Tethered Peptide Ligand of Human Thrombin Receptor for Phosphoinositide Hydrolysis

K. Sakaguchi, Y. Shimohigashi, H. Kodama, 1994 .

Sequence of a cDNA encoding bovine apolipoprotein H.

K. Sakaguchi, E. Appella, B. Gao, 1993, Gene.

Characterization of the active site and a unique uncompetitive inhibitor of the PPM1-type protein phosphatase PPM1D.

K. Sakaguchi, Tomohiko Fukuda, Y. Chuman, 2008, Protein Peptide Letters.

Inhibition of C-terminal truncated PPM1D enhances the effect of doxorubicin on cell viability in human colorectal carcinoma cell line.

K. Sakaguchi, Rui Kamada, K. Tanino, 2014, Bioorganic & medicinal chemistry letters.

Conformationally stabilized gramicidin S analog containing dehydrophenylalanine in place of d‐phenylalanine4,4′

K. Sakaguchi, Y. Shimohigashi, H. Kodama, 2009 .

Inhibition of Ser/Thr phosphatase PPM1D induces neutrophil differentiation in HL-60 cells

K. Sakaguchi, Rui Kamada, Fuki Kudoh, 2017, Journal of biochemistry.

Novel inhibitors targeting PPM1D phosphatase potently suppress cancer cell proliferation.

K. Sakaguchi, Rui Kamada, Y. Chuman, 2015, Bioorganic & medicinal chemistry.

Dimeric substance P analogue shows a highly potent activity of the in vivo salivary secretion in the rat.

K. Sakaguchi, Y. Shimohigashi, H. Kodama, 1989, European journal of pharmacology.

Characterization of a C-Terminal SUMO-Interacting Motif Present in Select PIAS-Family Proteins.

K. Sakaguchi, J. Omichinski, Rui Kamada, 2020, Structure.

Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner.

K. Sakaguchi, J. Omichinski, M. Lussier-Price, 2019, Structure.

Oligomerization enhances the binding affinity of a silver biomineralization peptide and catalyzes nanostructure formation

K. Sakaguchi, J. Omichinski, M. Lussier-Price, 2017, Scientific Reports.

High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution.

A. Gronenborn, G. Clore, K. Sakaguchi, 1992, Biochemistry.

Effect of Phosphorylation on the Structure and Fold of Transactivation Domain of p53*

K. Sakaguchi, T. Kundu, Siddhartha Roy, 2002, The Journal of Biological Chemistry.

The high-resolution structure of the peripheral subunit-binding domain of dihydrolipoamide acetyltransferase from the pyruvate dehydrogenase multienzyme complex of Bacillus stearothermophilus.

Y. Kalia, K. Sakaguchi, E. Appella, 1994, Journal of molecular biology.

Role of active site arginine residues in substrate recognition by PPM1A.

K. Sakaguchi, S. Ito, J. Omichinski, 2021, Biochemical and biophysical research communications.

Synthetic antigenic peptides as a new strategy for immunotherapy of cancer.

A. Sette, K. Sakaguchi, E. Appella, 1995, Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity.

Effect of Phosphorylation on Tetramerization of the Tumor Suppressor Protein p53

H. Sakamoto, K. Sakaguchi, E. Appella, 1997, Journal of protein chemistry.

Bilayer Hydrogel Composed of Elastin-Mimetic Polypeptides as a Bio-Actuator with Bidirectional and Reversible Bending Behaviors

K. Sakaguchi, Rui Kamada, Y. Chuman, 2023, Molecules.

The oligomerization domain of p53: Crystal structure of the trigonal form

A. Gronenborn, G. Clore, H. Sakamoto, 1996, FEBS letters.

Effects of tumor-associated mutations in the p53 tetramerization domain on oligomerization state and transcriptional activity.

K. Sakaguchi, Rui Kamada, Y. Chuman, 2009, Advances in experimental medicine and biology.

Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO 1

K. Sakaguchi, G. Ferbeyre, J. Omichinski, 2014 .

Tetramer formation of tumor suppressor protein p53: Structure, function, and applications

K. Sakaguchi, Rui Kamada, Y. Toguchi, 2016, Biopolymers.