K. Rock

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Distinct proteolytic processes generate the C and N termini of MHC class I-binding peptides.

A. Goldberg, X. Mo, P. Cascio, 1999, Journal of immunology.

Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide.

A. Goldberg, K. Rock, A. Craiu, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.

K. Rock, G. Dranoff, Z. Shen, 1997, Journal of immunology.

26S proteasomes and immunoproteasomes produce mainly N‐extended versions of an antigenic peptide

A. Goldberg, P. Cascio, K. Rock, 2001, The EMBO journal.

Present Yourself! By MHC Class I and MHC Class II Molecules.

K. Rock, J. Neefjes, E. Reits, 2016, Trends in immunology.

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

K. Rock, V. Hornung, E. Latz, 2008, Nature Immunology.

Proteolysis, proteasomes and antigen presentation

A. Goldberg, K. Rock, Kenneth L. Rock, 1992, Nature.

The sterile inflammatory response.

Fernando Ontiveros, K. Rock, E. Latz, 2010, Annual review of immunology.

Overexpressed Ly-6A.2 mediates cell-cell adhesion by binding a ligand expressed on lymphoid cells.

K. Rock, A. Bamezai, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Presentation of exogenous antigen with class I major histocompatibility complex molecules.

K. Rock, S. Gamble, L. Rothstein, 1990, Science.

Internalization of glycosyl‐phosphatidylinositol (GPI)‐anchored lymphocyte proteins II. GPI‐anchored and transmembrane molecules internalize through distinct pathways

K. Rock, V. Goldmacher, A. Bamezai, 1992, European journal of immunology.

NLRP3 inflamasomes are required for atherogenesis and activated by cholesterol crystals that form early in disease

K. Moore, K. Rock, V. Hornung, 2010, Nature.

Degradation of cell proteins and the generation of MHC class I-presented peptides.

A. Goldberg, K. Rock, A L Goldberg, 1999, Annual review of immunology.

The Specificity of Trimming of MHC Class I-Presented Peptides in the Endoplasmic Reticulum1

K. Rock, I. York, Arron Hearn, 2009, The Journal of Immunology.

Anti-Peptide Antibody Blocks Peptide Binding to MHC Class I Molecules in the Endoplasmic Reticulum1

K. Rock, C. Hilton, A. M. Dahl, 2001, Journal of Immunology.

A new foreign policy: MHC class I molecules monitor the outside world.

K. Rock, 1996, Immunology today.

Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages.

K. Rock, B. Benacerraf, M. Kovacsovics-Bankowski, 1993, Proceedings of the National Academy of Sciences of the United States of America.

A Novel Approach to Recovery of Function of Mutant Proteins by Slowing Down Translation*

K. Rock, M. Sherman, H. Bihler, 2012, The Journal of Biological Chemistry.

Priming of T cells by exogenous antigen cross-presented on MHC class I molecules.

K. Rock, Lianjun Shen, 2006, Current opinion in immunology.

Inhibition of antigen-specific T lymphocyte activation by structurally related Ir gene-controlled polymers. Evidence of specific competition for accessory cell antigen presentation

K. Rock, B. Benacerraf, 1983, The Journal of experimental medicine.

Characterization of a proapoptotic antiganglioside GM2 monoclonal antibody and evaluation of its therapeutic effect on melanoma and small cell lung carcinoma xenografts.

K. Rock, B. Woda, M. Retter, 2005, Cancer research.

Fully mobilizing host defense: Building better vaccines

K. Rock, S. Raychaudhuri, 1998, Nature Biotechnology.

Presentation of exogenous antigens by macrophages: analysis of major histocompatibility complex class I and II presentation and regulation by cytokines

K. Rock, Magdalena, Kovacsovics‐Bankowski, 1994, European journal of immunology.

Oncofetal Protein IMP3, a New Diagnostic Biomarker to Distinguish Malignant Mesothelioma From Reactive Mesothelial Proliferation

K. Rock, Zhong Jiang, B. Woda, 2011, The American journal of surgical pathology.

Sterile Cell Death Stimulates the Inflammatory Response to Identification of the Cellular Sensor That

K. Rock, Y. Iwakura, H. Kono, 2010 .

Identification of the Cellular Sensor That Stimulates the Inflammatory Response to Sterile Cell Death

K. Rock, Y. Iwakura, H. Kono, 2010, The Journal of Immunology.

Pathobiology of inflammation to cell death.

K. Rock, 2009, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Cutting Edge: Elimination of an Endogenous Adjuvant Reduces the Activation of CD8 T Lymphocytes to Transplanted Cells and in an Autoimmune Diabetes Model

K. Rock, Yan Shi, S. A. Galusha, 2006, The Journal of Immunology.

Mammaglobin and CRxA‐01 in pleural effusion cytology

K. Rock, G. Fanger, Ashraf Khan, 2004, Cancer.

The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8+ T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi

K. Rock, R. Gazzinelli, E. Cunha-Neto, 2016, PLoS pathogens.

Mice completely lacking immunoproteasomes display major alterations in antigen presentation

K. Rock, A. Murphy, G. Yancopoulos, 2011, Nature Immunology.

Targeting antigen into the phagocytic pathway in vivo induces protective tumour immunity

K. Rock, M. Kovacsovics-Bankowski, L. Falo, 1995, Nature Medicine.

Characterization of MHC class II‐presented peptides generated from an antigen targeted to different endocytic compartments

K. Rock, D. M. Fernandes, L. Vidard, 2000, European journal of immunology.

Gamma‐interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages

A. Goldberg, K. Rock, Tamara T. Laha, 1995, FEBS letters.

A Mutant Cell with a Novel Defect in MHC Class I Quality Control1

K. Rock, E. Grant, I. York, 2005, The Journal of Immunology.

of CD8 T Cell Responses in Antigen Presentation and the Generation Analysis of the Role of Bleomycin Hydrolase

K. Rock, J. Lazo, L. Watkin, 2007 .

Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy

A. Goldberg, K. Rock, D. Rubinsztein, 2010, Human molecular genetics.

Role of proteasomes in antigen presentation.

A. Goldberg, K. Rock, M. Gaczynska, 1993, Enzyme & protein.

Heterogeneity in antigen processing by different types of antigen-presenting cells. Effect of cell culture on antigen processing ability.

K. Rock, B. Benacerraf, L. Vidard, 1992, Journal of immunology.

The generation of immunogenic peptides can be selectively increased or decreased by proteolytic enzyme inhibitors.

K. Rock, B. Benacerraf, L. Vidard, 1991, Journal of immunology.

Class II antigen processing defects in two H2 dmouse cell lines are caused by point mutations in the H2‐DMagene

K. Rock, J. Monaco, I. York, 1999, European journal of immunology.

CD 4 T Cell Memory Even in the Absence of + CD 8 Programming , Maintenance , and Recall of CD 40 on APCs Is Needed for Optimal Rock

K. Rock, Lianjun Shen, M. G. H. Hernandez, 2008 .

CD40 on APCs Is Needed for Optimal Programming, Maintenance, and Recall of CD8+ T Cell Memory Even in the Absence of CD4+ T Cell Help1

K. Rock, Lianjun Shen, M. G. H. Hernandez, 2008, The Journal of Immunology.

Differentiate into Memory Cells Proliferate, Develop Effector Function, and Stimulate Naive CD8 T Cells In Vivo to Both Dendritic Cells and Macrophages Can

K. Rock, J. Maciaszek, L. Pozzi, 2005 .

The xanthine oxidase inhibitor Febuxostat reduces tissue uric acid content and inhibits injury-induced inflammation in the liver and lung.

K. Rock, H. Kataoka, Ke Yang, 2015, European journal of pharmacology.

Characterization of antigen-presenting cells that present exogenous antigens in association with class I MHC molecules.

K. Rock, S. Gamble, L. Rothstein, 1993, Journal of immunology.

19 – The Role of Specific B Lymphocytes in Antigen Processing and Presentation to T Cells

K. Rock, B. Benacerraf, A. Abbas, 1988 .

Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors

K. Rock, B. Benacerraf, A. Abbas, 1984, The Journal of experimental medicine.

Stimulation of human Jurkat cells by monoclonal antibody crosslinking of transfected-Ly-6A.2 (TAP) molecules.

K. Rock, J. McGrew, 1991, Cellular immunology.

CD4+ T cells mature in the absence of MHC class I and class II expression in Ly-6A.2 transgenic mice.

K. Rock, A. Berezovskaya, D. Palliser, 1998, Journal of immunology.

Transgenic Mice Class I and Class II Expression in Ly-6 A . 2 T Cells Mature in the Absence of MHC + CD 4

K. Rock, A. Berezovskaya, C. Henderson, 1998 .

Cytotoxic T lymphocytes in resistance to tuberculosis.

K. Rock, B. Bloom, S. Porcelli, 1998, Advances in experimental medicine and biology.

Regulated expression of Ly-6A.2 is important for T cell development.

K. Rock, E. Lacy, A. Berezovskaya, 1995, Journal of immunology.

Cloning and expression of a cDNA for the T-cell-activating protein TAP.

K. Rock, B. Benacerraf, E. Palmer, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Isolation, expression, and sequence of the TAP/Ly-6A.2 chromosomal gene.

K. Rock, J. McGrew, 1991, Journal of immunology.

Analysis of thymocyte MHC specificity with thymocyte hybridomas

K. Rock, E. Yeh, B. Benacerraf, 1984, The Journal of experimental medicine.

Analysis of the association of peptides of optimal length to class I molecules on the surface of cells.

K. Rock, B. Benacerraf, L. Rothstein, 1992, Proceedings of the National Academy of Sciences of the United States of America.

h Accumulation of a Substantial Pool of Inactive Class I MHC Heavy Chains on the Cell Surface

K. Rock, B. Benacerraf, S. Gamble, 1991 .

KOC (K Homology Domain Containing Protein Overexpressed in Cancer): A Novel Molecular Marker That Distinguishes Between Benign and Malignant Lesions of the Pancreas

R. Yantiss, K. Rock, D. Andersen, 2005, The American journal of surgical pathology.

Phospholipase treatment of accessory cells that have been exposed to antigen selectively inhibits antigen-specific Ia-restricted, but not allospecific, stimulation of T lymphocytes.

K. Rock, B. Benacerraf, L. Falo, 1986, Proceedings of the National Academy of Sciences of the United States of America.

IL-1 Generated Subsequent to Radiation-Induced Tissue Injury Contributes to the Pathogenesis of Radiodermatitis

K. Rock, T. Fitzgerald, F. Ontiveros, 2012, Radiation research.

MHC class I-restricted presentation of exogenous antigen by thymic antigen-presenting cells in vitro and in vivo.

K. Rock, E. Grant, Ethan P. Grant, 1992, Journal of immunology.

Two genetically identical antigen-presenting cell clones display heterogeneity in antigen processing.

K. Rock, B. Benacerraf, M. Michalek, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury.

K. Rock, Jiann-jyh Lai, Freidrich M. Cruz, 2019, Immunity.

Antigen Presentation

K. Rock, 2020, Definitions.

Antigen presentation by hapten‐specific B lymphocytes III. Analysis of the immunoglobulin‐dependent pathway of antigen presentation to interleukin 1‐dependent T lymphocytes

K. Rock, B. Benacerraf, A. Abbas, 1986, European journal of immunology.

Both Dendritic Cells and Macrophages Can Stimulate Naive CD8 T Cells In Vivo to Proliferate, Develop Effector Function, and Differentiate into Memory Cells1

K. Rock, J. Maciaszek, L. Pozzi, 2005, The Journal of Immunology.

The role of Ia molecules in the activation of T lymphocytes. I. The activation of an IL 1-dependent IL 2-producing T cell hybridoma by Con A requires an interaction, which is not H-2-restricted, with an Ia-bearing accessory cell.

K. Rock, 1982, Journal of immunology.

Expression of a novel oncofetal mRNA-binding protein IMP3 in endometrial carcinomas: diagnostic significance and clinicopathologic correlations

K. Rock, A. Fischer, V. Zota, 2007, Modern Pathology.

The Biological Significance of the Antigens of the Major Histocompatibility Complex

K. Rock, B. Benacerraf, 1985 .

MHC‐Restricted T Cell Activation: Analysis with T Cell Hybridomas

K. Rock, B. Benacerraf, 1983, Immunological reviews.

TAP transcription and phosphatidylinositol linkage mutants are defective in activation through the T cell receptor

K. Rock, E. Yeh, H. Reiser, 1988, Cell.

Functional T-Cell Hybridomas

K. Rock, 1985 .

IMP3, a New Biomarker to Predict Progression of Cervical Intraepithelial Neoplasia Into Invasive Cancer

K. Rock, Zhong Jiang, B. Woda, 2011, The American journal of surgical pathology.

1 – Processing of Native Antigen by Accessory Cells and Presentation of Membrane-Bound MHC-Associated Antigen to Specific T Cells1

K. Rock, B. Benacerraf, L. Falo, 1988 .

The role of H-2 linked genes in helper T-cell function. II. Isolation on antigen-pulsed macrophages of two separate populations of F1 helper T cells each specific for antigen and one set of parental H-2 products

K. Rock, P. Marrack, J. Kappler, 1978, The Journal of experimental medicine.

Thymic T cells are driven to expand upon interaction with self-class II major histocompatibility complex gene products on accessory cells.

K. Rock, B. Benacerraf, 1984, Proceedings of the National Academy of Sciences of the United States of America.

How dying cells alert the immune system to danger

K. Rock, H. Kono, Kenneth L. Rock, 2008, Nature Reviews Immunology.

The class II MHC-restricted presentation of endogenously synthesized ovalbumin displays clonal variation, requires endosomal/lysosomal processing, and is up-regulated by heat shock.

K. Rock, B. Benacerraf, M. Michalek, 1992, Journal of immunology.

Reassociation with beta 2-microglobulin is necessary for Db class I major histocompatibility complex binding of an exogenous influenza peptide.

K. Rock, B. Benacerraf, S. Gamble, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Diversity in MHC class II ovalbumin T cell epitopes generated by distinct proteases.

K. Rock, B. Benacerraf, L. Vidard, 1992, Journal of immunology.

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

A. Goldberg, K. Rock, L. Dick, 1994, Cell.

The ins and outs of cross-presentation

K. Rock, 2003, Nature Immunology.

Selective modification of a private I-A allo-stimulating determinant(s) upon association of antigen with an antigen-presenting cell

K. Rock, B. Benacerraf, 1984, The Journal of experimental medicine.

Structural characterization of the TAP molecule: A phosphatidylinositol-linked glycoprotein distinct from the T cell receptor/T3 complex and Thy-1

K. Rock, E. Yeh, B. Benacerraf, 1986, Cell.

Tetraspanin-5–mediated MHC class I clustering is required for optimal CD8 T cell activation

K. Rock, Jeff D. Colbert, Christina E. Baer, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Serum proteases alter the antigenicity of peptides presented by class I major histocompatibility complex molecules.

K. Rock, B. Benacerraf, L. Falo, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Stimulation of B lymphocytes through surface Ig receptors induces LFA-1 and ICAM-1-dependent adhesion.

K. Rock, L. Dang, K. L. Rock, 1991, Journal of immunology.

Stimulation of T cells via the TAP molecule, a member in a family of activating proteins encoded in the Ly-6 locus.

K. Rock, E. Yeh, J. Daley, 1987, Journal of immunology.

The oncofetal protein IMP3: a novel molecular marker to predict aggressive meningioma.

K. Rock, Zhong Jiang, B. Woda, 2011, Archives of pathology & laboratory medicine.

Analysis of MHC class II presentation of particulate antigens of B lymphocytes.

K. Rock, B. Benacerraf, S. Kraeft, 1996, Journal of immunology.

Exiting the outside world for cross-presentation.

K. Rock, 2006, Immunity.

Natural endogenous adjuvants

K. Rock, Arron Hearn, Yan Shi, 2004, Springer Seminars in Immunopathology.

Molecular identification of a danger signal that alerts the immune system to dying cells

James E. Evans, Yan Shi, K. Rock, 2003, Nature.

Cell death releases endogenous adjuvants that selectively enhance immune surveillance of particulate antigens

Yan Shi, K. Rock, Kenneth L. Rock, 2002, European journal of immunology.

Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses.

K. Rock, Y. Shi, W. Zheng, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Proteolysis and class I major histocompatibility complex antigen presentation

A. Goldberg, X. Mo, K. Rock, 1999, Immunological reviews.

Interferon-γ Can Stimulate Post-proteasomal Trimming of the N Terminus of an Antigenic Peptide by Inducing Leucine Aminopeptidase*

A. Goldberg, K. Rock, J. Beninga, 1998, The Journal of Biological Chemistry.

Leucine Aminopeptidase Is Not Essential for Trimming Peptides in the Cytosol or Generating Epitopes for MHC Class I Antigen Presentation1

K. Rock, A. Murphy, G. Yancopoulos, 2005, The Journal of Immunology.

The inflammatory response to cell death.

K. Rock, H. Kono, 2008, Annual review of pathology.

Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation

K. Rock, Jeff D. Colbert, Karthik Dhatchinamoorthy, 2021, Frontiers in Immunology.

The IL-1–Dependent Sterile Inflammatory Response Has a Substantial Caspase-1–Independent Component That Requires Cathepsin C

K. Rock, H. Kono, Zubin H. Patel, 2012, The Journal of Immunology.

Proteases in MHC Class I Presentation and Cross-Presentation

K. Rock, Diego J. Farfán-Arribas, Lianjun Shen, 2009, The Journal of Immunology.

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Egil Lien, Katherine A. Fitzgerald, George S. Abela, 2010, Nature.

Antigen processing and presentation by the class I major histocompatibility complex.

K. Rock, I. York, 1996, Annual review of immunology.

The LY‐6 Locus: A Multigene Family Encoding Phosphatidylinositol‐Anchored Membrane Proteins Concerned with T‐Cell Activation

K. Rock, B. Benacerraf, H. Reiser, 1989, Immunological reviews.

Uric acid as a danger signal in gout and its comorbidities

Hiroshi Kataoka, K. Rock, Kenneth L. Rock, 2013, Nature Reviews Rheumatology.

Alpha‐methylacyl‐CoA racemase: a multi‐institutional study of a new prostate cancer marker

Ximing J. Yang, K. Iczkowski, K. Rock, 2004, Histopathology.

Internalization of phosphatidylinositol-anchored lymphocyte proteins. I. Documentation and potential significance for T cell stimulation.

K. Rock, H. Reiser, V. Goldmacher, 1989, Journal of immunology.

Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen

R. Andino, K. Rock, S. Crotty, 1999, Nature.

Poliovirus vaccine vectors elicit antigen-specific cytotoxic T cells and protect mice against lethal challenge with malignant melanoma cells expressing a model antigen.

R. Andino, K. Rock, S. Mandl, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Processing and presentation of ovalbumin in mice genetically selected for antibody response

K. Rock, B. Benacerraf, L. Vidard, 1992, European journal of immunology.

Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7.

A. Goldberg, K. Rock, M. Gaczynska, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Protein degradation and the generation of MHC class I-presented peptides.

A. Goldberg, K. Rock, T. Šarić, 2002, Advances in immunology.

SPECIFIC ANTIGENIC COMPETITION FOR ACCESSORY CELL PRESENTATION Monoclonal Antibodies

K. Rock, B. Benacerraf, 2003 .

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

S. Akira, K. Rock, D. Golenbock, 2007, Nature Medicine.

The role of Ia molecules in the activation of T lymphocytes. II. Ia-restricted recognition of allo K/D antigens is required for class I MHC-stimulated mixed lymphocyte responses.

K. Rock, R. Germain, B. Benacerraf, 1983, Journal of immunology.

A role for the ubiquitin-dependent proteolytic pathway in MHC class l-restricted antigen presentation

A. Goldberg, K. Rock, E. Grant, 1993, Nature.

Analysis of the role of MHC class II presentation in the stimulation of cytotoxic T lymphocytes by antigens targeted into the exogenous antigen-MHC class I presentation pathway.

K. Rock, K. Clark, K. L. Rock, 1996, Journal of immunology.

CD40-CD40 Ligand Interaction between Dendritic Cells and CD8+ T Cells Is Needed to Stimulate Maximal T Cell Responses in the Absence of CD4+ T Cell Help1

K. Rock, Lianjun Shen, M. G. H. Hernandez, 2007, The Journal of Immunology.

Cross‐presentation: underlying mechanisms and role in immune surveillance

K. Rock, Lianjun Shen, Kenneth L. Rock, 2005, Immunological reviews.

Structural Basis For Antigenic Peptide Precursor Processing by the Endoplasmic Reticulum Aminopeptidase ERAP1

A. Goldberg, K. Rock, Shi-Chung Chang, 2011, Nature Structural &Molecular Biology.

Microbiota signalling through MyD88 is necessary for a systemic neutrophilic inflammatory response

K. Rock, Dipti Karmarkar, 2013, Immunology.

An IFN-γ–induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I–presented peptides

Akira Hattori, A. Goldberg, K. Rock, 2002, Nature Immunology.

Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen

R. Andino, K. Rock, S. Crotty, 1999, Nature.

IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16INK4a expression

K. Rock, Zhong Jiang, B. Woda, 2007, Modern Pathology.

IL-1 generated subsequent to radiation-induced tissue injury contributes to the pathogenesis of radiodermatitis.

K. Rock, T. Fitzgerald, A. Deng, 2012, Radiation research.

A dietary enzyme: α-methylacyl-CoA racemase/P504S is overexpressed in colon carcinoma

K. Rock, S. Reed, Zhong Jiang, 2003 .

The Biology and Underlying Mechanisms of Cross-Presentation of Exogenous Antigens on MHC-I Molecules.

K. Rock, Jeff D. Colbert, B. Kriegsman, 2017, Annual review of immunology.

Oncofetal protein IMP3

K. Rock, C. Lohse, Zhong Jiang, 2008, Cancer.

A Novel Molecular Marker That Predicts Metastasis of Papillary and Chromophobe Renal Cell Carcinomas

K. Rock, C. Lohse, Zhong Jiang, 2008 .

Peptide-priming of cytolytic T cell immunity in vivo using beta 2-microglobulin as an adjuvant.

K. Rock, S. Gamble, C. Fleischacker, 1993, Journal of immunology.

Combination of Quantitative IMP3 and Tumor Stage: A New System to Predict Metastasis for Patients with Localized Renal Cell Carcinomas

K. Rock, Zhong Jiang, B. Woda, 2008, Clinical Cancer Research.

Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study.

K. Rock, Zhong Jiang, B. Woda, 2006, The Lancet. Oncology.

Pathways of MHC I cross-presentation of exogenous antigens.

K. Rock, Amanda Chan, Freidrich M Cruz, 2023, Seminars in immunology.

Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection.

K. Rock, H. Ploegh, B. Bloom, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Two distinct mechanisms regulate the in vivo generation of cytotoxic T cells

K. Rock, B. Benacerraf, M. Sy, 1982, The Journal of experimental medicine.

Inhibition of antigen-specific T lymphocyte activation by structurally related Ir gene-controlled polymers. II. Competitive inhibition of I-E- restricted, antigen-specific T cell responses

K. Rock, B. Benacerraf, 1984, The Journal of experimental medicine.

Post-proteasomal antigen processing for major histocompatibility complex class I presentation

A. Goldberg, K. Rock, I. York, 2004, Nature Immunology.

Multiple Cathepsins Promote Pro–IL-1β Synthesis and NLRP3-Mediated IL-1β Activation

M. Bogyo, K. Rock, Shruti Sharma, 2015, The Journal of Immunology.

The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation.

A. Goldberg, K. Lemerise, K. Rock, 2003, Immunity.

The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8–9 residues

A. Goldberg, K. Rock, Shi-Chung Chang, 2002, Nature Immunology.

The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides.

A. Goldberg, P. Cascio, K. Rock, 2002, Molecular immunology.

Major Histocompatibility Complex Class I-presented Antigenic Peptides Are Degraded in Cytosolic Extracts Primarily by Thimet Oligopeptidase*

A. Goldberg, K. Rock, T. Akopian, 2001, The Journal of Biological Chemistry.

Bone Marrow–Derived Antigen-Presenting Cells Are Required for the Generation of Cytotoxic T Lymphocyte Responses to Viruses and Use Transporter Associated with Antigen Presentation (Tap)-Dependent and -Independent Pathways of Antigen Presentation

K. Rock, L. Sigal, 2000, The Journal of experimental medicine.

Uric acid promotes an acute inflammatory response to sterile cell death in mice.

K. Rock, H. Kono, Chun-jen Chen, 2010, The Journal of clinical investigation.

A monoclonal antibody reactive with a 40-kDa molecule on fetal thymocytes and tumor cells blocks proliferation and stimulates aggregation and apoptosis.

K. Rock, L. Berg, D. M. Fernandes, 1999, Journal of immunology.

Stimulates Aggregation and Apoptosis Tumor Cells Blocks Proliferation and 40-kDa Molecule on Fetal Thymocytes and A Monoclonal Antibody Reactive with a

K. Rock, L. Berg, D. M. Fernandes, 1999 .

Functions of the proteasome in antigen presentation.

A. Goldberg, K. Rock, M. Gaczynska, 1995, Cold Spring Harbor symposia on quantitative biology.

Functions of the proteasome in antigen presentation.

A. Goldberg, K. Rock, M. Gaczynska, 1995, Cold Spring Harbor symposia on quantitative biology.

Using intein catalysis to probe the origin of major histocompatibility complex class I-presented peptides

K. Rock, L. Stern, Diego J. Farfán-Arribas, 2012, Proceedings of the National Academy of Sciences.

Reassociation with beta 2-microglobulin is necessary for Kb class I major histocompatibility complex binding of exogenous peptides.

K. Rock, B. Benacerraf, S. Gamble, 1990, Proceedings of the National Academy of Sciences of the United States of America.

T cell receptor/CD3 negative variants are unresponsive to stimulation through the Ly-6 encoded molecule, TAP.

K. Rock, H. Reiser, A. Bamezai, 1988, Journal of immunology.

The expression, function, and ontogeny of a novel T cell-activating protein, TAP, in the thymus.

K. Rock, E. Yeh, B. Benacerraf, 1986, Journal of immunology.

TAP, a novel T cell-activating protein involved in the stimulation of MHC-restricted T lymphocytes

K. Rock, E. Yeh, B. Benacerraf, 1986, The Journal of experimental medicine.

MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals.

S. Akira, K. Rock, D. Golenbock, 2006, The Journal of clinical investigation.

Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo.

K. Rock, M. Boes, L. Sigal, 2004, Immunity.

Analysis of antigen presentation by metabolically inactive accessory cells and their isolated membranes.

K. Rock, B. Benacerraf, M. Mescher, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes.

A. Goldberg, K. Rock, M. Gaczynska, 1993, Nature.

Innate and adaptive immune responses to cell death

K. Rock, H. Kono, Jiann-jyh Lai, 2011, Immunological reviews.

Cross-presentation of exogenous antigens on MHC I molecules.

K. Rock, Jeff D. Colbert, Freidrich M Cruz, 2020, Current opinion in immunology.

Puromycin-Sensitive Aminopeptidase Limits MHC Class I Presentation in Dendritic Cells but Does Not Affect CD8 T Cell Responses during Viral Infections1

K. Rock, A. Murphy, G. Yancopoulos, 2008, The Journal of Immunology.

during Viral Infections but Does Not Affect CD8 T Cell Responses MHC Class I Presentation in Dendritic Cells Puromycin-Sensitive Aminopeptidase Limits

K. Rock, A. Murphy, G. Yancopoulos, 2008 .

Frontline Science: Multiple cathepsins promote inflammasome‐independent, particle‐induced cell death during NLRP3‐dependent IL‐1β activation

M. Bogyo, K. Rock, Shruti Sharma, 2017, Journal of leukocyte biology.

The GTPase Rab39a promotes phagosome maturation into MHC‐I antigen‐presenting compartments

K. Rock, Jeff D. Colbert, Freidrich M Cruz, 2019, The EMBO journal.

Role of ICAM-1 in antigen presentation demonstrated by ICAM-1 defective mutants.

K. Rock, F. Takei, M. Michalek, 1990, Journal of immunology.

Rate of antigen degradation by the ubiquitin-proteasome pathway influences MHC class I presentation.

A. Goldberg, K. Rock, E. Grant, 1995, Journal of immunology.

A dietary enzyme: alpha-methylacyl-CoA racemase/P504S is overexpressed in colon carcinoma.

K. Rock, S. Reed, Zhong Jiang, 2003, Cancer detection and prevention.

Altered peptidase and viral-specific T cell response in LMP2 mutant mice.

S. Tonegawa, A. Goldberg, M. Eichelberger, 1994, Immunity.

Characterizing the Specificity and Cooperation of Aminopeptidases in the Cytosol and Endoplasmic Reticulum during MHC Class I Antigen Presentation

K. Rock, I. York, Arron Hearn, 2010, The Journal of Immunology.

The Specificity of Trimming of MHC Class

K. Rock, Arron Hearn, 2009 .

Inhibition of class I and class II MHC-restricted antigen presentation by cytotoxic T lymphocytes specific for an exogenous antigen.

K. Rock, S. Gamble, L. Rothstein, 1992, Journal of immunology.

Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance.

K. Rock, C. Towne, M. Brehm, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression

A. Brass, K. Rock, P. Meraner, 2019, The Journal of Immunology.

Antigen presentation by hapten-specific B lymphocytes. II. Specificity and properties of antigen-presenting B lymphocytes, and function of immunoglobulin receptors.

K. Rock, A. Abbas, K L Rock, 1985, Journal of immunology.

Cross-Presentation Proteases in MHC Class I Presentation and

K. Rock, Lianjun Shen, 2009 .

Low temperature and peptides favor the formation of class I heterodimers on RMA-S cells at the cell surface.

K. Rock, B. Benacerraf, C. Gramm, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Dissociation of β 2-microglobulin leads to the accumulation of a substantial pool of inactive class I MHC heavy chains on the cell surface

K. Rock, B. Benacerraf, Kenneth L. Rock, 1991, Cell.

Lactacystin and clasto-Lactacystin β-Lactone Modify Multiple Proteasome β-Subunits and Inhibit Intracellular Protein Degradation and Major Histocompatibility Complex Class I Antigen Presentation*

A. Goldberg, K. Rock, A. Craiu, 1997, The Journal of Biological Chemistry.

Sequences That Flank Subdominant and Cryptic Epitopes Influence the Proteolytic Generation of MHC Class I-Presented Peptides1

K. Rock, A. Craiu, Kenneth L. Rock, 2000, The Journal of Immunology.

Peptides Generation of MHC Class I-Presented Cryptic Epitopes Influence the Proteolytic Sequences That Flank Subdominant

K. Rock, A. Craiu, Annie X. Y. Mo, 2000 .

The interaction between class II MHC molecules and antigens as a basis for Ir gene specificity.

K. Rock, B. Benacerraf, 1984, Annales d'immunologie.

tovirus-infected non-haematopoietic cells requires presentation of exogenous antigen

R. Andino, K. Rock, S. Crotty, 1999 .

Generation of class I MHC-restricted T-T hybridomas.

K. Rock, S. Gamble, L. Rothstein, 1990, Journal of immunology.

Cellular protein is the source of cross-priming antigen in vivo.

K. Rock, Lianjun Shen, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Proteasome Subunits X and Y Alter Peptidase Activities in Opposite Ways to the Interferon-γ-induced Subunits LMP2 and LMP7*

A. Goldberg, K. Rock, M. Gaczynska, 1996, The Journal of Biological Chemistry.

Analysis of the Role of Tripeptidyl Peptidase II in MHC Class I Antigen Presentation In Vivo1

M. Kawahara, K. Rock, I. York, 2009, The Journal of Immunology.

Vivo II in MHC Class I Antigen Presentation In Analysis of the Role of Tripeptidyl Peptidase Farfan

M. Kawahara, K. Rock, Arron Hearn, 2009 .

Analysis of the Role of Bleomycin Hydrolase in Antigen Presentation and the Generation of CD8 T Cell Responses1

K. Rock, J. Lazo, L. Watkin, 2007, The Journal of Immunology.

Tripeptidyl Peptidase II Is the Major Peptidase Needed to Trim Long Antigenic Precursors, but Is Not Required for Most MHC Class I Antigen Presentation1

A. Goldberg, K. Rock, I. York, 2006, The Journal of Immunology.

The role of B7-1 and B7-2 costimulation for the generation of CTL responses in vivo.

K. Rock, H. Reiser, L. Sigal, 1998, Journal of immunology.

the Generation of CTL Responses In Vivo The Role of B7-1 and B7-2 Costimulation for

K. Rock, H. Reiser, L. Sigal, 1998 .

Evaluation of the Contribution of Multiple DAMPs and DAMP Receptors in Cell Death-Induced Sterile Inflammatory Responses

K. Rock, H. Kono, Zubin H. Patel, 2014, PloS one.

Not just research tools—proteasome inhibitors offer therapeutic promise

A. Goldberg, K. Rock, 2002, Nature Medicine.

A gradient of adhesive specificity in developing avian retina.

K. Rock, D. Gottlieb, L. Glaser, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Re-examining class-I presentation and the DRiP hypothesis.

A. Goldberg, K. Rock, Jeff D. Colbert, 2014, Trends in immunology.

The role of Ia molecules in the activation of T lymphocytes. III. Antigen-specific, Ia-restricted, interleukin 2-producing T cell hybridomas with detectable affinity for the restricting I-A molecule

K. Rock, B. Benacerraf, 1983, The Journal of experimental medicine.

Chemical denaturation and modification of ovalbumin alters its dependence on ubiquitin conjugation for class I antigen presentation.

K. Rock, E. Grant, M. Michalek, 1996, Journal of immunology.

Substrate-Induced Protein Stabilization Reveals a Predominant Contribution from Mature Proteins to Peptides Presented on MHC Class I

K. Rock, Jeff D. Colbert, Diego J. Farfán-Arribas, 2013, The Journal of Immunology.

Generating Epitopes for MHC Class I Trimming Peptides in the Cytosol or Leucine Aminopeptidase Is Not Essential for Yancopoulos

K. Rock, A. Murphy, G. Yancopoulos, 2005 .

An Oncofetal Protein IMP3: A New Molecular Marker for the Detection of Esophageal Adenocarcinoma and High-grade Dysplasia

K. Rock, Zhong Jiang, B. Woda, 2009, The American journal of surgical pathology.

Specialized proteasome subunits play an essential role in thymic selection of CD8+ T cells

K. Rock, Keiji Tanaka, S. Murata, 2016, Nature Immunology.

Tumor immune evasion through loss of MHC class-I antigen presentation.

K. Rock, Gulce Sari, 2023, Current opinion in immunology.

A mutant antigen-presenting cell defective in antigen presentation expresses class II MHC molecules with an altered conformation.

K. Rock, B. Benacerraf, L. Lien, 1993, Journal of immunology.

γ-lnterferon and expression of MHC genes regulate peptide hydrolysis by proteasomes

A. Goldberg, K. Rock, M. Gaczynska, 1995, Nature.

IMP 3 Predicts Aggressive Superficial Urothelial Carcinoma of the Bladder

K. Rock, B. Woda, S. Mohanty, 2008 .

Combination of Quantitative IMP 3 andTumor Stage : ANew System to Predict Metastasis for Patients with Localized Renal Cell Carcinomas

K. Rock, B. Woda, Chin-Lee Wu, 2008 .

Not just research tools—proteasome inhibitors offer therapeutic promise

A. Goldberg, K. Rock, 2002, Nature Medicine.

Involvement of Syngeneic Ia in T Cell Responses to Class I Alloantigens

K. Rock, R. Germain, S. Burakoff, 1983 .

Endoplasmic Reticulum Aminopeptidase 1 Vitro but in Patterns Distinct from Generates Mature Antigenic Peptides in Placental Leucine Aminopeptidase Efficiently

K. Rock, L. Leondiadis, Irini Evnouchidou, 2022 .

Cerulenin is a potent inhibitor of antigen processing by antigen-presenting cells.

K. Rock, B. Benacerraf, L. Rothstein, 1987, Journal of immunology.

Characterization of antigen association with accessory cells: specific removal of processed antigens from the cell surface by phospholipases.

K. Rock, B. Benacerraf, S. Herrmann, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Evidence for a Gradient of Adhesive Specificity in the Developing Chick Retina

K. Rock, D. Gottlieb, L. Glaser, 1976 .

Correction: Multiple Cathepsins Promote Pro–IL-1β Synthesis and NLRP3-Mediated IL-1β Activation

M. Bogyo, K. Rock, Shruti Sharma, 2016, The Journal of Immunology.

Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1.

K. Rock, L. Leondiadis, Irini Evnouchidou, 2010, Journal of immunology.

Chemical cross-linking of class I molecules on cells creates receptive peptide binding sites.

K. Rock, B. Benacerraf, S. Gamble, 1992, Journal of immunology.

the Endoplasmic Reticulum Binding to MHC Class I Molecules in Anti-Peptide Antibody Blocks Peptide

K. Rock, A. M. Dahl, Craig J. Hilton, 2010 .

Placental Leucine Aminopeptidase Efficiently Generates Mature Antigenic Peptides In Vitro but in Patterns Distinct from Endoplasmic Reticulum Aminopeptidase 1

K. Rock, L. Leondiadis, Irini Evnouchidou, 2010, Journal of Immunology.

Innate and adaptive immune responses to cell death

K. Rock, H. Kono, Jiann-jyh Lai, 2011, Immunological reviews.

The Specificity of Trimming of MHC Class I-Presented Peptides in the Endoplasmic Reticulum1

K. Rock, I. York, Arron Hearn, 2009, The Journal of Immunology.

Re-examining class-I presentation and the DRiP hypothesis.

A. Goldberg, K. Rock, Jeff D. Colbert, 2014, Trends in immunology.

Analysis of thymocyte MHC specificity with thymocyte hybridomas

B. S. Tan, K. Rock, Damian H. Evans, 1984, The Journal of experimental medicine.

oxidase-induced oxidant injury in isolated rabbit lungs Role of neutrophils in xanthine/xanthine

K. Rock, T. Dahms, Y. Iwakura, 2015 .

Inhibition of antigen-specific T lymphocyte activation by structurally related Ir gene-controlled polymers. Evidence of specific competition for accessory cell antigen presentation

K. Rock, B. Benacerraf, 1983, The Journal of experimental medicine.

Selective modification of a private I-A allo-stimulating determinant(s) upon association of antigen with an antigen-presenting cell

K. Rock, B. Benacerraf, 1984, The Journal of experimental medicine.

Oncofetal Protein IMP3, a New Diagnostic Biomarker to Distinguish Malignant Mesothelioma From Reactive Mesothelial Proliferation

K. Rock, Zhong Jiang, B. Woda, 2011, The American journal of surgical pathology.

Combination of Quantitative IMP3 and Tumor Stage: A New System to Predict Metastasis for Patients with Localized Renal Cell Carcinomas

K. Rock, Zhong Jiang, B. Woda, 2008, Clinical Cancer Research.

Characterizing the Specificity and Cooperation of Aminopeptidases in the Cytosol and Endoplasmic Reticulum during MHC Class I Antigen Presentation

K. Rock, I. York, Arron Hearn, 2010, The Journal of Immunology.

Weak base amines can inhibit class I MHC-restricted antigen presentation.

K. Rock, B. Benacerraf, M. Michalek, 1991, Journal of immunology.

The role of Ia molecules in the activation of T lymphocytes. IV. The basis of the thymocyte IL 1 response and its possible role in the generation of the T cell repertoire.

K. Rock, B. Benacerraf, 1984, Journal of immunology.

Selection of thymocyte MHC restriction specificity in vitro.

K. Rock, E. Yeh, B. Benacerraf, 1984, The Journal of molecular and cellular immunology : JMCI.

How a tailor achieves the perfect fit

K. Rock, Jeff D. Colbert, 2020, The Journal of Biological Chemistry.