F. Belluti

发表

Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives.

A. Cavalli, V. Andrisano, L. Piazzi, 2007, Journal of medicinal chemistry.

Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors.

A. Cavalli, L. Piazzi, F. Belluti, 2009, European journal of medicinal chemistry.

Phenolic 1,3‐diketones attenuate lipopolysaccharide‐induced inflammatory response by an alternative magnesium‐mediated mechanism

S. Moro, F. Belluti, P. Brun, 2017, British journal of pharmacology.

Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent.

F. Belluti, A. Bisi, S. Gobbi, 2019, Bioorganic chemistry.

Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds.

A. Cavalli, V. Andrisano, L. Piazzi, 2008, Bioorganic & medicinal chemistry letters.

2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents.

V. Andrisano, F. Belluti, A. Bisi, 2012, European journal of medicinal chemistry.

Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors.

A. Cavalli, V. Andrisano, G. Bottegoni, 2016, Journal of medicinal chemistry.

Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part II: curcumin derivatives in cancer and neurodegeneration

F. Belluti, A. Bisi, S. Gobbi, 2017, Expert opinion on therapeutic patents.

Modulation of Amyloid β-Induced Microglia Activation and Neuronal Cell Death by Curcumin and Analogues

F. Belluti, M. Zusso, R. D. Di Martino, 2022, International journal of molecular sciences.

Chalcone-based carbamates for Alzheimer's disease treatment.

A. Cavalli, F. Belluti, A. Bisi, 2017, Future medicinal chemistry.

Improved eradication efficacy of a combination of newly identified antimicrobial agents in C. albicans and S. aureus mixed-species biofilm.

F. Belluti, A. Bisi, S. Gobbi, 2021, Research in microbiology.

Reconsidering Aromatase for Breast Cancer Treatment: New Roles for an Old Target

F. Belluti, A. Bisi, S. Gobbi, 2020, Molecules.

Toward the Development of Dual‐Targeted Glyceraldehyde‐3‐phosphate Dehydrogenase/Trypanothione Reductase Inhibitors against Trypanosoma brucei and Trypanosoma cruzi

A. Cavalli, F. Belluti, M. Bolognesi, 2014, ChemMedChem.

Single-digit nanomolar inhibitors lock the aromatase active site via a dualsteric targeting strategy.

F. Belluti, A. Bisi, S. Gobbi, 2022, European journal of medicinal chemistry.

Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts.

F. Belluti, A. Bisi, S. Gobbi, 2022, Bioorganic chemistry.

Homopterocarpanes as bridged triarylethylene analogues: synthesis and antagonistic effects in human MCF-7 breast cancer cells.

L. Piazzi, F. Belluti, A. Bisi, 2005, Farmaco.

Bisdemethoxycurcumin and Its Cyclized Pyrazole Analogue Differentially Disrupt Lipopolysaccharide Signalling in Human Monocyte-Derived Macrophages

F. Belluti, L. Facci, S. Skaper, 2018, Mediators of inflammation.

Flavonoid-Inspired Vascular Disrupting Agents: Exploring Flavone-8-Acetic Acid and Derivatives in the New Century

F. Belluti, A. Bisi, S. Gobbi, 2021, Molecules.

Natural-like Chalcones with Antitumor Activity on Human MG63 Osteosarcoma Cells

F. Belluti, A. Bisi, S. Gobbi, 2022, Molecules.

Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI).

A. Cavalli, F. Belluti, A. Bisi, 2013, Journal of medicinal chemistry.

Targeting the bacterial membrane with a new polycyclic privileged structure: a powerful tool to face Staphylococcus aureus infections.

F. Belluti, A. Bisi, S. Gobbi, 2019, ACS infectious diseases.

Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents.

V. Andrisano, F. Belluti, A. Bisi, 2016, Journal of medicinal chemistry.

Functionalization of the Chalcone Scaffold for the Discovery of Novel Lead Compounds Targeting Fungal Infections

F. Belluti, A. Bisi, S. Gobbi, 2019, Molecules.

Dual BACE-1/GSK-3β Inhibitors to Combat Alzheimer's Disease: A Focused Review.

F. Belluti, A. Bisi, S. Gobbi, 2018, Current topics in medicinal chemistry.

Mono- or di-fluorinated analogues of flavone-8-acetic acid: synthesis and in vitro biological activity.

L. Piazzi, F. Belluti, A. Bisi, 2005, Anticancer research.

New derivatives of xanthenone-4-acetic acid: synthesis, pharmacological profile and effect on TNF-alpha and NO production by human immune cells.

L. Piazzi, F. Belluti, A. Bisi, 2006, Bioorganic & medicinal chemistry.

Complementary medicinal chemistry-driven strategies toward new antitrypanosomal and antileishmanial lead drug candidates.

A. Cavalli, L. Piazzi, F. Belluti, 2010, FEMS immunology and medical microbiology.

Synthesis and biological evaluation of 3-alkoxy analogues of flavone-8-acetic acid.

L. Piazzi, F. Belluti, A. Bisi, 2003, Journal of medicinal chemistry.

Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation.

Silvia Gobbi, Maurizio Recanatini, Christina Zimmer, 2010, Journal of medicinal chemistry.

Synthesis, cytotoxicity and SAR of simple geiparvarin analogues.

F. Belluti, A. Bisi, M. Recanatini, 1997, Anti-cancer drug design.

1,4-Dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety.

L. Piazzi, F. Belluti, A. Bisi, 2005, Bioorganic & medicinal chemistry.

Design, synthesis and anticancer activities of stilbene-coumarin hybrid compounds: Identification of novel proapoptotic agents.

F. Belluti, F. Zunino, N. Carenini, 2010, Bioorganic & medicinal chemistry.

Synthesis and biological activity of some rigid analogues of flavone-8-acetic acid.

F. Belluti, A. Bisi, S. Gobbi, 2000, Bioorganic & medicinal chemistry.

Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity.

F. Belluti, A. Bisi, S. Gobbi, 2017, European journal of medicinal chemistry.

From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold.

A. Cavalli, V. Andrisano, F. Belluti, 2015, Bioorganic & medicinal chemistry letters.

Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.

A. Cavalli, V. Andrisano, G. Bottegoni, 2011, European journal of medicinal chemistry.

Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers.

V. Andrisano, F. Belluti, A. Bisi, 2011, European journal of medicinal chemistry.

Cardiovascular hybrid drugs: new benzazepinone derivatives as bradycardic agents endowed with selective beta1-non-competitive antagonism.

F. Belluti, A. Bisi, S. Gobbi, 2003, Bioorganic & medicinal chemistry.

Design, synthesis and biological profile of new inhibitors of multidrug resistance associated proteins carrying a polycyclic scaffold.

F. Belluti, A. Bisi, S. Gobbi, 2015, European journal of medicinal chemistry.

Acetylcholinesterase inhibitors for potential use in Alzheimer's disease: molecular modeling, synthesis and kinetic evaluation of 11H-indeno-[1,2-b]-quinolin-10-ylamine derivatives.

A. Cavalli, V. Andrisano, V. Cavrini, 2000, Bioorganic & medicinal chemistry.

Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis.

F. Belluti, A. Bisi, S. Gobbi, 2016, Journal of medicinal chemistry.

3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy.

A. Cavalli, V. Andrisano, L. Piazzi, 2003, Journal of medicinal chemistry.

In vitro evaluation of newly developed chalcone analogues in human cancer cells

F. Belluti, P. Valenti, F. Ranelletti, 2000, Cancer Chemotherapy and Pharmacology.

Potent inhibition of human phosphodiesterase-5 by icariin derivatives.

F. Belluti, M. Dell’Agli, G. Galli, 2008, Journal of natural products.

Identification of chalcone-based antileishmanial agents targeting trypanothione reductase.

F. Belluti, A. Bisi, S. Gobbi, 2018, European journal of medicinal chemistry.

Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme.

A. Cavalli, L. Piazzi, F. Belluti, 2006, Journal of medicinal chemistry.

Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach.

Silvia Gobbi, Maurizio Recanatini, Andrea Cavalli, 2005, Journal of medicinal chemistry.

A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.

A. Cavalli, F. Belluti, A. Bisi, 2001, Journal of medicinal chemistry.

Synthesis of a series of Homopterocarpane derivatives with potential antitumor and anti-AIDS activity.

F. Belluti, A. Bisi, A. Rampa, 1997, Farmaco.

New potent P-glycoprotein inhibitors carrying a polycyclic scaffold.

L. Piazzi, F. Belluti, A. Bisi, 2006, Journal of medicinal chemistry.

Curcumin-1,2,3-Triazole Conjugation for Targeting the Cancer Apoptosis Machinery

F. Belluti, A. Bisi, S. Gobbi, 2020, Molecules.

Imidazolylmethylbenzophenones as highly potent aromatase inhibitors.

Silvia Gobbi, Maurizio Recanatini, Andrea Cavalli, 2007, Journal of medicinal chemistry.

Prenylated Curcumin Analogues as Multipotent Tools To Tackle Alzheimer's Disease.

F. Belluti, M. Catanzaro, C. Lanni, 2018, ACS chemical neuroscience.

Chitosan nanoparticles for lipophilic anticancer drug delivery: Development, characterization and in vitro studies on HT29 cancer cells.

F. Belluti, B. Luppi, F. Bigucci, 2016, Colloids and surfaces. B, Biointerfaces.

Synthesis and antitumor activity of new derivatives of xanthen-9-one-4-acetic acid.

F. Belluti, A. Bisi, S. Gobbi, 2002, Journal of medicinal chemistry.

Synthesis of flavone-2'-carboxylic acid analogues as potential antitumor agents.

F. Belluti, A. Bisi, S. Gobbi, 1998, Anti-cancer drug design.

Acetylcholinesterase inhibitors: SAR and kinetic studies on omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives.

A. Cavalli, V. Andrisano, V. Cavrini, 2001, Journal of medicinal chemistry.

Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile.

F. Belluti, M. Bolognesi, R. Krauth-Siegel, 2012, Journal of medicinal chemistry.

Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson’s Disease

F. Belluti, A. Bisi, S. Gobbi, 2020, ACS chemical neuroscience.

Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part I: Curcumin

F. Belluti, A. Bisi, S. Gobbi, 2017, Expert opinion on therapeutic patents.

Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 – 2012)

F. Belluti, A. Bisi, S. Gobbi, 2013, Expert opinion on therapeutic patents.

SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues.

A. Cavalli, V. Andrisano, V. Cavrini, 2000, Journal of medicinal chemistry.

A Simple One-Pot Synthesis of Isoflavanones

F. Belluti, A. Bisi, A. Rampa, 1999 .

A Simple One-Pot Synthesis of Isoflavanones.

F. Belluti, A. Bisi, A. Rampa, 1999 .

The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease?

V. Andrisano, F. Belluti, A. Bisi, 2012, ACS medicinal chemistry letters.

New Coumarin Derivatives as Cholinergic and Cannabinoid System Modulators

F. Belluti, A. Bisi, S. Gobbi, 2021, Molecules.

Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease.

A. Cavalli, V. Andrisano, G. Bottegoni, 2014, European journal of medicinal chemistry.

Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold.

F. Belluti, A. Bisi, S. Gobbi, 2023, European journal of medicinal chemistry.

Targeting Steroidogenic Cytochromes P450 (CYPs) with 6‐Substituted 1‐Imidazolylmethylxanthones

F. Belluti, A. Bisi, S. Gobbi, 2016, ChemMedChem.

Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing.

F. Belluti, A. Bisi, S. Gobbi, 2019, Bioorganic chemistry.

Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation.

A. Cavalli, V. Andrisano, L. Piazzi, 2005, Journal of medicinal chemistry.

Switching from Aromatase Inhibitors to Dual Targeting Flavonoid-Based Compounds for Breast Cancer Treatment

F. Belluti, A. Bisi, S. Gobbi, 2023, Molecules.

Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer.

F. Belluti, A. Bisi, S. Gobbi, 2021, European journal of medicinal chemistry.

Multitarget Compounds for Bipolar Disorder: From Rational Design to Preliminary Pharmacokinetic Evaluation

A. Cavalli, G. Bottegoni, F. Belluti, 2020, ChemMedChem.

Quinone-Amino Acid Conjugates Targeting Leishmania Amino Acid Transporters

F. Belluti, M. Bolognesi, F. Lizzi, 2014, PloS one.

Cardiovascular Profile of Xanthone-Based 1,4 Dihydropyridines Bearing a Lidoflazine Pharmacophore Fragment

F. Belluti, A. Bisi, S. Gobbi, 2018, Molecules.

Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment.

F. Belluti, A. Bisi, S. Gobbi, 2019, European journal of medicinal chemistry.

Nonsteroidal aromatase inhibitors for the treatment of breast cancer: an update.

F. Belluti, A. Bisi, S. Gobbi, 2014, Anti-cancer agents in medicinal chemistry.

Drifting of heme-coordinating group in imidazolylmethylxanthones leading to improved selective inhibition of CYP11B1.

F. Belluti, A. Bisi, S. Gobbi, 2017, European journal of medicinal chemistry.

Structure–Activity Relationships and Binding Mode in the Human Acetylcholinesterase Active Site of Pseudo‐Irreversible Inhibitors Related to Xanthostigmine

A. Cavalli, V. Andrisano, F. Belluti, 2009, ChemMedChem.

Design, Synthesis and Structure—Activity Relationships of a Phenotypic Small Library against Protozoan Infections

Maria Paola Costi, L. Piazzi, F. Belluti, 2017 .

Multifaceted activity of polyciclic MDR revertant agents in drug-resistant leukemic cells: Role of the spacer.

F. Belluti, A. Bisi, S. Gobbi, 2020, Bioorganic chemistry.

Development of a Focused Library of Triazole‐Linked Privileged‐Structure‐Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections

Maria Paola Costi, L. Piazzi, F. Belluti, 2018, ChemMedChem.

Naturally Inspired Molecules as Multifunctional Agents for Alzheimer’s Disease Treatment

F. Belluti, A. Bisi, S. Gobbi, 2016, Molecules.

Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin‐Based Derivatives

A. Cavalli, V. Andrisano, F. Belluti, 2016, ChemMedChem.

Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment.

F. Belluti, A. Bisi, S. Gobbi, 2019, European journal of medicinal chemistry.

Hybrid-based multi-target ligands for the treatment of Alzheimer's disease.

F. Belluti, A. Bisi, S. Gobbi, 2011, Current topics in medicinal chemistry.

Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer’s Disease

F. Belluti, A. Bisi, S. Gobbi, 2018, Molecules.

Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones.

V. Andrisano, L. Piazzi, F. Belluti, 2007, Bioorganic & medicinal chemistry.

Tackling Alzheimer's Disease with Existing Drugs: Playing Dirty for Bypassing Obstacles.

F. Belluti, A. Bisi, S. Gobbi, 2020, Current medicinal chemistry.

Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold.

F. Belluti, A. Bisi, S. Gobbi, 2023, European journal of medicinal chemistry.

Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities.

F. Belluti, A. Bisi, S. Gobbi, 2019, ACS medicinal chemistry letters.

Hitting drug-resistant malaria infection with triazole-linked flavonoid-chloroquine hybrid compounds.

F. Belluti, A. Bisi, S. Gobbi, 2022, Future medicinal chemistry.