A. Bisi

发表

Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives.

A. Cavalli, V. Andrisano, L. Piazzi, 2007, Journal of medicinal chemistry.

Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors.

A. Cavalli, L. Piazzi, F. Belluti, 2009, European journal of medicinal chemistry.

Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent.

F. Belluti, A. Bisi, S. Gobbi, 2019, Bioorganic chemistry.

Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity.

V. Andrisano, L. Piazzi, A. Bisi, 2008, Journal of medicinal chemistry.

2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents.

V. Andrisano, F. Belluti, A. Bisi, 2012, European journal of medicinal chemistry.

The ability of coumarin-, flavanon- and flavonol-analogues of flavone acetic acid to stimulate human monocytes.

A. Bisi, S. Gobbi, A. Rampa, 2008, Oncology reports.

From nonsteroidal aromatase inhibitors to multifunctional drug candidates: classic and innovative strategies for the treatment of breast cancer.

A. Cavalli, A. Bisi, S. Gobbi, 2008, Current topics in medicinal chemistry.

Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors.

A. Cavalli, V. Andrisano, G. Bottegoni, 2016, Journal of medicinal chemistry.

Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part II: curcumin derivatives in cancer and neurodegeneration

F. Belluti, A. Bisi, S. Gobbi, 2017, Expert opinion on therapeutic patents.

Chalcone-based carbamates for Alzheimer's disease treatment.

A. Cavalli, F. Belluti, A. Bisi, 2017, Future medicinal chemistry.

Improved eradication efficacy of a combination of newly identified antimicrobial agents in C. albicans and S. aureus mixed-species biofilm.

F. Belluti, A. Bisi, S. Gobbi, 2021, Research in microbiology.

Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.

A. Bisi, S. Gobbi, M. Negri, 2008, Journal of medicinal chemistry.

Reconsidering Aromatase for Breast Cancer Treatment: New Roles for an Old Target

F. Belluti, A. Bisi, S. Gobbi, 2020, Molecules.

Single-digit nanomolar inhibitors lock the aromatase active site via a dualsteric targeting strategy.

F. Belluti, A. Bisi, S. Gobbi, 2022, European journal of medicinal chemistry.

Antimicrotubular and cytotoxic activity of geiparvarin analogues, alone and in combination with paclitaxel

A. Bisi, A. Rampa, P. Valenti, 2001, Cell biochemistry and function.

Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts.

F. Belluti, A. Bisi, S. Gobbi, 2022, Bioorganic chemistry.

Homopterocarpanes as bridged triarylethylene analogues: synthesis and antagonistic effects in human MCF-7 breast cancer cells.

L. Piazzi, F. Belluti, A. Bisi, 2005, Farmaco.

Coumarin 1,4-dihydropyridine derivatives.

A. Bisi, A. Rampa, P. Valenti, 1998, Bioorganic & medicinal chemistry.

1,4-Dihydropyridines bearing a pharmacophoric fragment of lidoflazine.

A. Bisi, A. Rampa, P. Valenti, 1996, Bioorganic & medicinal chemistry.

Flavonoid-Inspired Vascular Disrupting Agents: Exploring Flavone-8-Acetic Acid and Derivatives in the New Century

F. Belluti, A. Bisi, S. Gobbi, 2021, Molecules.

Natural-like Chalcones with Antitumor Activity on Human MG63 Osteosarcoma Cells

F. Belluti, A. Bisi, S. Gobbi, 2022, Molecules.

Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI).

A. Cavalli, F. Belluti, A. Bisi, 2013, Journal of medicinal chemistry.

Targeting the bacterial membrane with a new polycyclic privileged structure: a powerful tool to face Staphylococcus aureus infections.

F. Belluti, A. Bisi, S. Gobbi, 2019, ACS infectious diseases.

Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents.

V. Andrisano, F. Belluti, A. Bisi, 2016, Journal of medicinal chemistry.

Functionalization of the Chalcone Scaffold for the Discovery of Novel Lead Compounds Targeting Fungal Infections

F. Belluti, A. Bisi, S. Gobbi, 2019, Molecules.

Dual BACE-1/GSK-3β Inhibitors to Combat Alzheimer's Disease: A Focused Review.

F. Belluti, A. Bisi, S. Gobbi, 2018, Current topics in medicinal chemistry.

Mono- or di-fluorinated analogues of flavone-8-acetic acid: synthesis and in vitro biological activity.

L. Piazzi, F. Belluti, A. Bisi, 2005, Anticancer research.

New derivatives of xanthenone-4-acetic acid: synthesis, pharmacological profile and effect on TNF-alpha and NO production by human immune cells.

L. Piazzi, F. Belluti, A. Bisi, 2006, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 3-alkoxy analogues of flavone-8-acetic acid.

L. Piazzi, F. Belluti, A. Bisi, 2003, Journal of medicinal chemistry.

Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation.

Silvia Gobbi, Maurizio Recanatini, Christina Zimmer, 2010, Journal of medicinal chemistry.

Synthesis, cytotoxicity and SAR of simple geiparvarin analogues.

F. Belluti, A. Bisi, M. Recanatini, 1997, Anti-cancer drug design.

1,4-Dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety.

L. Piazzi, F. Belluti, A. Bisi, 2005, Bioorganic & medicinal chemistry.

Synthesis and biological activity of some rigid analogues of flavone-8-acetic acid.

F. Belluti, A. Bisi, S. Gobbi, 2000, Bioorganic & medicinal chemistry.

Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity.

F. Belluti, A. Bisi, S. Gobbi, 2017, European journal of medicinal chemistry.

From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold.

A. Cavalli, V. Andrisano, F. Belluti, 2015, Bioorganic & medicinal chemistry letters.

Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.

A. Cavalli, V. Andrisano, G. Bottegoni, 2011, European journal of medicinal chemistry.

Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers.

V. Andrisano, F. Belluti, A. Bisi, 2011, European journal of medicinal chemistry.

Cardiovascular hybrid drugs: new benzazepinone derivatives as bradycardic agents endowed with selective beta1-non-competitive antagonism.

F. Belluti, A. Bisi, S. Gobbi, 2003, Bioorganic & medicinal chemistry.

Design, synthesis and biological profile of new inhibitors of multidrug resistance associated proteins carrying a polycyclic scaffold.

F. Belluti, A. Bisi, S. Gobbi, 2015, European journal of medicinal chemistry.

Acetylcholinesterase inhibitors for potential use in Alzheimer's disease: molecular modeling, synthesis and kinetic evaluation of 11H-indeno-[1,2-b]-quinolin-10-ylamine derivatives.

A. Cavalli, V. Andrisano, V. Cavrini, 2000, Bioorganic & medicinal chemistry.

Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis.

F. Belluti, A. Bisi, S. Gobbi, 2016, Journal of medicinal chemistry.

Selective cardiodepressant activity of fluodipine, a fluorenone-1,4-dihydropyridine derivative.

A. Bisi, A. Rampa, P. Valenti, 1998, European Journal of Pharmacology.

SAR studies in the field of Ca-antagonists: 2-substituted 1,4-dihydropyridines with a xanthone backbone.

A. Bisi, A. Rampa, P. Valenti, 1993, Farmaco.

3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy.

A. Cavalli, V. Andrisano, L. Piazzi, 2003, Journal of medicinal chemistry.

Identification of chalcone-based antileishmanial agents targeting trypanothione reductase.

F. Belluti, A. Bisi, S. Gobbi, 2018, European journal of medicinal chemistry.

Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme.

A. Cavalli, L. Piazzi, F. Belluti, 2006, Journal of medicinal chemistry.

Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach.

Silvia Gobbi, Maurizio Recanatini, Andrea Cavalli, 2005, Journal of medicinal chemistry.

A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.

A. Cavalli, F. Belluti, A. Bisi, 2001, Journal of medicinal chemistry.

Synthesis of a series of Homopterocarpane derivatives with potential antitumor and anti-AIDS activity.

F. Belluti, A. Bisi, A. Rampa, 1997, Farmaco.

New potent P-glycoprotein inhibitors carrying a polycyclic scaffold.

L. Piazzi, F. Belluti, A. Bisi, 2006, Journal of medicinal chemistry.

Curcumin-1,2,3-Triazole Conjugation for Targeting the Cancer Apoptosis Machinery

F. Belluti, A. Bisi, S. Gobbi, 2020, Molecules.

Imidazolylmethylbenzophenones as highly potent aromatase inhibitors.

Silvia Gobbi, Maurizio Recanatini, Andrea Cavalli, 2007, Journal of medicinal chemistry.

Synthesis and Bone Resorption Effect of Alkoxy‐Substituted Xanthones

A. Bisi, P. Valenti, G. Pifferi, 1997, Archiv der Pharmazie.

Synthesis and Bone Resorption Effect of Alkoxy‐Substituted Xanthones ( I).

A. Bisi, P. Valenti, G. Pifferi, 1997 .

Synthesis of the 3-Homologue of Ipriflavone.

A. Bisi, P. Valenti, G. Pifferi, 1997 .

Synthesis and antitumor activity of new derivatives of xanthen-9-one-4-acetic acid.

F. Belluti, A. Bisi, S. Gobbi, 2002, Journal of medicinal chemistry.

Synthesis of flavone-2'-carboxylic acid analogues as potential antitumor agents.

F. Belluti, A. Bisi, S. Gobbi, 1998, Anti-cancer drug design.

Synthesis and antitumor activity of some analogues of flavone acetic acid.

A. Bisi, S. Gobbi, A. Rampa, 1996, Anti-cancer drug design.

Acetylcholinesterase inhibitors: SAR and kinetic studies on omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives.

A. Cavalli, V. Andrisano, V. Cavrini, 2001, Journal of medicinal chemistry.

Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson’s Disease

F. Belluti, A. Bisi, S. Gobbi, 2020, ACS chemical neuroscience.

Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part I: Curcumin

F. Belluti, A. Bisi, S. Gobbi, 2017, Expert opinion on therapeutic patents.

Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 – 2012)

F. Belluti, A. Bisi, S. Gobbi, 2013, Expert opinion on therapeutic patents.

SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues.

A. Cavalli, V. Andrisano, V. Cavrini, 2000, Journal of medicinal chemistry.

Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives.

A. Bisi, S. Gobbi, A. Rampa, 2008, Bioorganic & medicinal chemistry.

A Simple One-Pot Synthesis of Isoflavanones

F. Belluti, A. Bisi, A. Rampa, 1999 .

A Simple One-Pot Synthesis of Isoflavanones.

F. Belluti, A. Bisi, A. Rampa, 1999 .

The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease?

V. Andrisano, F. Belluti, A. Bisi, 2012, ACS medicinal chemistry letters.

New Coumarin Derivatives as Cholinergic and Cannabinoid System Modulators

F. Belluti, A. Bisi, S. Gobbi, 2021, Molecules.

Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease.

A. Cavalli, V. Andrisano, G. Bottegoni, 2014, European journal of medicinal chemistry.

Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold.

F. Belluti, A. Bisi, S. Gobbi, 2023, European journal of medicinal chemistry.

Targeting Steroidogenic Cytochromes P450 (CYPs) with 6‐Substituted 1‐Imidazolylmethylxanthones

F. Belluti, A. Bisi, S. Gobbi, 2016, ChemMedChem.

Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing.

F. Belluti, A. Bisi, S. Gobbi, 2019, Bioorganic chemistry.

Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation.

A. Cavalli, V. Andrisano, L. Piazzi, 2005, Journal of medicinal chemistry.

Acetylcholinesterase inhibitors: synthesis and structure-activity relationships of omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)- methyl]aminoalkoxyheteroaryl derivatives.

A. Cavalli, V. Andrisano, V. Cavrini, 1998, Journal of medicinal chemistry.

New approaches to the treatment of Alzheimer's disease.

A. Bisi, A. Rampa, 2013, Current topics in medicinal chemistry.

Switching from Aromatase Inhibitors to Dual Targeting Flavonoid-Based Compounds for Breast Cancer Treatment

F. Belluti, A. Bisi, S. Gobbi, 2023, Molecules.

Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer.

F. Belluti, A. Bisi, S. Gobbi, 2021, European journal of medicinal chemistry.

Targeting Orthosteric and Allosteric Pockets of Aromatase via Dual-Mode Novel Azole Inhibitors.

A. Bisi, S. Gobbi, N. Zaffaroni, 2020, ACS medicinal chemistry letters.

A Computational Assay of Estrogen Receptor α Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers

A. Bisi, S. Gobbi, G. Colombo, 2018, Scientific Reports.

Cardiovascular Profile of Xanthone-Based 1,4 Dihydropyridines Bearing a Lidoflazine Pharmacophore Fragment

F. Belluti, A. Bisi, S. Gobbi, 2018, Molecules.

Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment.

F. Belluti, A. Bisi, S. Gobbi, 2019, European journal of medicinal chemistry.

Nonsteroidal aromatase inhibitors for the treatment of breast cancer: an update.

F. Belluti, A. Bisi, S. Gobbi, 2014, Anti-cancer agents in medicinal chemistry.

Synthesis and structure-activity relationships of cetiedil analogues as blockers of the Ca(2+)-activated K+ permeability of erythrocytes.

S Athmani, C R Ganellin, D. Jenkinson, 2001, Journal of medicinal chemistry.

Drifting of heme-coordinating group in imidazolylmethylxanthones leading to improved selective inhibition of CYP11B1.

F. Belluti, A. Bisi, S. Gobbi, 2017, European journal of medicinal chemistry.

Structure–Activity Relationships and Binding Mode in the Human Acetylcholinesterase Active Site of Pseudo‐Irreversible Inhibitors Related to Xanthostigmine

A. Cavalli, V. Andrisano, F. Belluti, 2009, ChemMedChem.

Multifaceted activity of polyciclic MDR revertant agents in drug-resistant leukemic cells: Role of the spacer.

F. Belluti, A. Bisi, S. Gobbi, 2020, Bioorganic chemistry.

Naturally Inspired Molecules as Multifunctional Agents for Alzheimer’s Disease Treatment

F. Belluti, A. Bisi, S. Gobbi, 2016, Molecules.

A Computational Assay of Estrogen Receptor α Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers

A. Bisi, S. Gobbi, G. Colombo, 2018, Scientific Reports.

Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin‐Based Derivatives

A. Cavalli, V. Andrisano, F. Belluti, 2016, ChemMedChem.

Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment.

F. Belluti, A. Bisi, S. Gobbi, 2019, European journal of medicinal chemistry.

Hybrid-based multi-target ligands for the treatment of Alzheimer's disease.

F. Belluti, A. Bisi, S. Gobbi, 2011, Current topics in medicinal chemistry.

Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer’s Disease

F. Belluti, A. Bisi, S. Gobbi, 2018, Molecules.

Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones.

V. Andrisano, L. Piazzi, F. Belluti, 2007, Bioorganic & medicinal chemistry.

Tackling Alzheimer's Disease with Existing Drugs: Playing Dirty for Bypassing Obstacles.

F. Belluti, A. Bisi, S. Gobbi, 2020, Current medicinal chemistry.

Acetylcholinesterase inhibition by tacrine analogues

V. Andrisano, V. Cavrini, A. Bisi, 1997 .

New approaches to the treatment of Alzheimer's disease.

A. Bisi, A. Rampa, 2013, Current topics in medicinal chemistry.

Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold.

F. Belluti, A. Bisi, S. Gobbi, 2023, European journal of medicinal chemistry.

Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities.

F. Belluti, A. Bisi, S. Gobbi, 2019, ACS medicinal chemistry letters.

Hitting drug-resistant malaria infection with triazole-linked flavonoid-chloroquine hybrid compounds.

F. Belluti, A. Bisi, S. Gobbi, 2022, Future medicinal chemistry.

Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11β-hydroxylase inhibition.

F. Belluti, A. Bisi, S. Gobbi, 2013, Journal of medicinal chemistry.

Identification of chalcone-based antileishmanial agents targeting trypanothione reductase.

F. Belluti, A. Bisi, S. Gobbi, 2018, European journal of medicinal chemistry.

Synthesis and pharmacological profile of some chloroxanthone-1, 4-dihydropyridine derivatives.

A. Bisi, A. Rampa, P. Valenti, 1996, Arzneimittel-Forschung.

Structure-activity relationship studies of xanthone and fluorenone-1,4-dihydropyridine-5-phosphonates.

A. Bisi, A. Rampa, P. Valenti, 1996, Arzneimittel-Forschung.

Fluorenone and benzophenone 1,4-dihydropyridine derivatives with cardiodepressant activity.

A. Bisi, A. Rampa, P. Valenti, 1992, Arzneimittel-Forschung.

Negative inotropic and chronotropic activity of calcium channel ligands possessing a xanthone 1,4-dihydropyridine backbone.

A. Bisi, A. Rampa, P. Valenti, 1992, Arzneimittel-Forschung.

4-heterotricyclic substituted 1,4-dihydropyridines with a potent selective bradycardic effect.

A. Bisi, A. Rampa, P. Valenti, 1991, Arzneimittel-Forschung.