M. Negri

发表

Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls.

Ulrike E. Hille, Qingzhong Hu, Carsten A. Vock, 2009, European journal of medicinal chemistry.

The Role of Fluorine Substitution in Biphenyl Methylene Imidazole‐Type CYP17 Inhibitors for the Treatment of Prostate Carcinoma

Qingzhong Hu, M. Negri, R. Hartmann, 2010, ChemMedChem.

Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.

Qingzhong Hu, M. Negri, M. Bartels, 2008, Bioorganic & medicinal chemistry.

A powerful combination of computational methods on the road toward potent non-steroidal inhibitors of steroidogenic enzymes involved in hormone-dependent diseases

M. Negri, 2010 .

Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives.

M. Negri, A. Abadi, H. Tinsley, 2012, European journal of medicinal chemistry.

Novel small molecule inhibitors targeting the "switch region" of bacterial RNAP: structure-based optimization of a virtual screening hit.

M. Negri, R. Hartmann, Jörg Haupenthal, 2013, European journal of medicinal chemistry.

Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer.

M. Negri, U. Müller-Vieira, T. Lauterbach, 2008, Journal of medicinal chemistry.

Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies

M. Negri, R. Hartmann, Christine K. Maurer, 2013, BMC biophysics.

Discovery of novel bacterial RNA polymerase inhibitors: pharmacophore-based virtual screening and hit optimization.

M. Negri, R. Hartmann, Jörg Haupenthal, 2013, Journal of medicinal chemistry.

Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.

A. Bisi, S. Gobbi, M. Negri, 2008, Journal of medicinal chemistry.

Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2).

M. Negri, R. Hartmann, Sarah Ulmschneider, 2006, Bioorganic & medicinal chemistry letters.

Inﬂuence of DNA Template Choice on Transcription and Inhibition of Escherichia coli RNA Polymerase

M. Negri, Christine K. Maurer, Joerg Haupenthal, 2012 .

Homology modeling meets site-directed mutagenesis: An ideal combination to elucidate the topology of 17β-HSD2

M. Negri, R. Hartmann, J. Adamski, 2020, The Journal of Steroid Biochemistry and Molecular Biology.

Structure optimization of 2-benzamidobenzoic acids as PqsD inhibitors for Pseudomonas aeruginosa infections and elucidation of binding mode by SPR, STD NMR, and molecular docking.

Michael P. Storz, M. Negri, R. Hartmann, 2013, Journal of medicinal chemistry.

Hydroxybenzothiazoles as New Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1)

Matthias Negri, M. Negri, M. Frotscher, 2012, PloS one.

Mechanistic details for anthraniloyl transfer in PqsD: the initial step in HHQ biosynthesis

M. Negri, R. Hartmann, Christina Zimmer, 2014, Journal of Molecular Modeling.

Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1).

M. Negri, R. Hartmann, M. Frotscher, 2008, Journal of medicinal chemistry.

Synthesis, biological evaluation and molecular modelling studies of novel ACD- and ABD-ring steroidomimetics as inhibitors of CYP17.

Ulrike E. Hille, M. Negri, R. Hartmann, 2008, Bioorganic & medicinal chemistry letters.

Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.

M. Negri, R. Hartmann, Christina Zimmer, 2011, Journal of medicinal chemistry.

Peptide-based investigation of the Escherichia coli RNA polymerase σ(70):core interface as target site.

M. Negri, R. Hartmann, S. Boettcher, 2013, ACS chemical biology.

Influence of DNA Template Choice on Transcription and Inhibition of Escherichia coli RNA Polymerase

M. Negri, R. Hartmann, Christine K. Maurer, 2012, Antimicrobial Agents and Chemotherapy.

Imidazolylmethylbenzophenones as highly potent aromatase inhibitors.

Silvia Gobbi, Maurizio Recanatini, Andrea Cavalli, 2007, Journal of medicinal chemistry.

17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: Protein structures, functions, and recent progress in inhibitor development

M. Negri, R. Hartmann, J. Adamski, 2011, The Journal of Steroid Biochemistry and Molecular Biology.

Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure.

Maurizio Recanatini, Andrea Cavalli, Thomas Lauterbach, 2008, Bioorganic & medicinal chemistry.

New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivity.

M. Negri, R. Hartmann, M. Frotscher, 2009, Journal of medicinal chemistry.

Computational investigation of the binding mode of bis(hydroxylphenyl)arenes in 17β-HSD1: molecular dynamics simulations, MM-PBSA free energy calculations, and molecular electrostatic potential maps

Maurizio Recanatini, Rolf W. Hartmann, Matthias Negri, 2011, J. Comput. Aided Mol. Des..

Novel estrone mimetics with high 17beta-HSD1 inhibitory activity.

M. Negri, R. Hartmann, M. Frotscher, 2010, Bioorganic & medicinal chemistry.

Structural optimization of 2,5-thiophene amides as highly potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of osteoporosis.

M. Negri, R. Hartmann, A. Odermatt, 2013, Journal of medicinal chemistry.

Composing compound libraries for hit discovery--rationality-driven preselection or random choice by structural diversity?

Matthias Negri, Elisabeth Weidel, Martin Empting, 2014, Future medicinal chemistry.

Structural Basis for Species Specific Inhibition of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Computational Study and Biological Validation

M. Negri, M. Frotscher, T. Klein, 2011, PloS one.

Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.

M. Negri, R. Hartmann, S. Lucas, 2008, Journal of medicinal chemistry.

CYP17 Inhibitors. Annulations of Additional Rings in Methylene Imidazole Substituted Biphenyls: Synthesis, Biological Evaluation and Molecular Modelling

Ulrike E. Hille, Qingzhong Hu, M. Negri, 2008, Archiv der Pharmazie.

Structure optimization of 2-benzamidobenzoic acids as PqsD inhibitors for Pseudomonas aeruginosa infections and elucidation of binding mode by SPR, STD NMR, and molecular docking.

Michael P. Storz, M. Negri, R. Hartmann, 2013, Journal of medicinal chemistry.

Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11β-hydroxylase inhibition.

F. Belluti, A. Bisi, S. Gobbi, 2013, Journal of medicinal chemistry.

Insights in 17β-HSD1 Enzyme Kinetics and Ligand Binding by Dynamic Motion Investigation

M. Recanatini, M. Negri, R. Hartmann, 2010, PloS one.

Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives.

M. Negri, A. Abadi, H. Tinsley, 2012, European journal of medicinal chemistry.

Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls.

Ulrike E. Hille, Qingzhong Hu, Carsten A. Vock, 2009, European journal of medicinal chemistry.