V. Tumiatti

发表

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.

A. Cavalli, V. Andrisano, M. Bartolini, 2008, Journal of medicinal chemistry.

Structure-activity relationships of novel substituted naphthalene diimides as anticancer agents.

V. Tumiatti, A. Milelli, A. Minarini, 2012, European journal of medicinal chemistry.

Multitarget-directed ligands: innovative chemical probes and therapeutic tools against Alzheimer's disease.

V. Tumiatti, A. Minarini, M. Rosini, 2011, Current topics in medicinal chemistry.

Multi-target-directed ligands to combat neurodegenerative diseases.

Maurizio Recanatini, Maria Laura Bolognesi, Andrea Cavalli, 2008, Journal of medicinal chemistry.

Tumor vascular targeted liposomal-bortezomib minimizes side effects and increases therapeutic activity in human neuroblastoma.

V. Tumiatti, A. Milelli, A. Minarini, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Application of an ESI‐QTOF method for the detailed characterization of GSK‐3&bgr; inhibitors

V. Andrisano, V. Tumiatti, A. Milelli, 2017, Journal of pharmaceutical and biomedical analysis.

Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer’s disease treatment

V. Andrisano, M. Bartolini, V. Tumiatti, 2012, Neuropharmacology.

Tacrine derivatives and Alzheimer's disease.

V. Tumiatti, A. Milelli, A. Minarini, 2010, Current medicinal chemistry.

Alpha 1-adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety.

V. Tumiatti, A. Minarini, M. Rosini, 2000, Pharmaceutica acta Helvetiae.

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer.

V. Andrisano, V. Tumiatti, A. Milelli, 2020, European journal of medicinal chemistry.

Heterocyclic inhibitors of AChE acylation and peripheral sites.

A. Cavalli, V. Andrisano, M. Bartolini, 2005, Farmaco.

Effect of polyamines on the nicotinic ACh receptor

V. Tumiatti, B. Dworakowska, E. Nurowska, 2018, Journal of Pre-Clinical and Clinical Research.

Exploring the effects of isothiocyanates on chemotherapeutic drugs

V. Tumiatti, A. Milelli, A. Minarini, 2014, Expert opinion on drug metabolism & toxicology.

Development of an UHPLC-diode arrays detector (DAD) method for the analysis of polydatin in human plasma.

V. Andrisano, V. Tumiatti, A. Gaddi, 2021, Journal of pharmaceutical and biomedical analysis.

Design, synthesis and biological evaluation of new naphtalene diimides bearing isothiocyanate functionality.

V. Tumiatti, A. Milelli, A. Minarini, 2012, European journal of medicinal chemistry.

Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties.

V. Tumiatti, A. Milelli, A. Minarini, 2007, Bioorganic & medicinal chemistry.

Polymethylene tetraamine backbone as template for the development of biologically active polyamines

V. Tumiatti, A. Minarini, M. Rosini, 2003, Medicinal research reviews.

Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra‐amines

V. Tumiatti, A. Minarini, M. Rosini, 2001, British journal of pharmacology.

Bovine Serum Amine Oxidase and Polyamine Analogues: Chemical Synthesis and Biological Evaluation Integrated with Molecular Docking and 3-D QSAR Studies

V. Tumiatti, A. Milelli, A. Minarini, 2022, J. Chem. Inf. Model..

Integrated analytical approaches for the characterization of Spirulina and Chlorella microalgae.

V. Andrisano, V. Tumiatti, A. De Simone, 2022, Journal of pharmaceutical and biomedical analysis.

Tetraamines as lead compounds for the design of neurotransmitter receptor ligands:Focus on α-adrenergic and muscarinic receptors recognition

V. Tumiatti, A. Minarini, M. Bolognesi, 1996 .

Design, synthesis and biological activity of some 4-DAMP- related compounds

M. Recanatini, V. Tumiatti, A. Minarini, 1995 .

DESIGN, SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME TETRAAMINES RELATED TO METHOCTRAMINE AND 4-DAMP

V. Tumiatti, A. Minarini, C. Melchiorre, 1995 .

The design of novel methoctramine-related tetraamines as muscarinic receptor subtype selective antagonists.

V. Tumiatti, A. Minarini, C. Melchiorre, 1995, Life sciences.

Multifunctional tacrine derivatives in Alzheimer's disease.

V. Tumiatti, A. Milelli, A. Minarini, 2013, Current topics in medicinal chemistry.

Macrocyclic naphthalene diimides as G-quadruplex binders.

Stephan A. Ohnmacht, V. Tumiatti, A. Milelli, 2015, Bioorganic & medicinal chemistry.

Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease.

E. Novellino, V. Andrisano, V. Tumiatti, 2019, ACS medicinal chemistry letters.

Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics.

V. Tumiatti, A. Minarini, M. Rosini, 2008, Bioorganic & medicinal chemistry.

Bis(7)‐tacrine Derivatives as Multitarget‐Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities

V. Andrisano, M. Bartolini, V. Tumiatti, 2010, ChemMedChem.

Study of the Cytotoxic Effects of the New Synthetic Isothiocyanate CM9 and Its Fullerene Derivative on Human T-Leukemia Cells

M. Prato, V. Tumiatti, A. Milelli, 2015, Toxins.

MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond.

V. Andrisano, M. Bartolini, V. Tumiatti, 2009, Current pharmaceutical design.

Synthetic polyamines activating autophagy: effects on cancer cell death.

V. Tumiatti, A. Milelli, A. Minarini, 2013, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists.

P. Usherwood, V. Tumiatti, A. Minarini, 1999, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds.

V. Tumiatti, M. Rosini, C. Melchiorre, 2005, Journal of medicinal chemistry.

Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate.

V. Tumiatti, A. Milelli, A. Minarini, 2016, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent.

V. Tumiatti, A. Milelli, A. Minarini, 2009, Journal of medicinal chemistry.

Determination of the dissociation constants (pKa) of basic acetylcholinesterase inhibitors by reversed-phase liquid chromatography.

A. Cavalli, R. Gotti, V. Andrisano, 2002, Journal of chromatography. A.

Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.

David W McClymont, Andrea Cavalli, David W. McClymont, 2008, Journal of medicinal chemistry.

Combined Methodologies for Determining In Vitro Bioavailability of Drugs and Prediction of In Vivo Bioequivalence From Pharmaceutical Oral Formulations

V. Andrisano, V. Tumiatti, A. De Simone, 2021, Frontiers in Chemistry.

Antagonist binding profile of the split chimeric muscarinic m2-trunc/m3-tail receptor.

A Minarini, M L Bolognesi, V. Tumiatti, 1998, European journal of pharmacology.

Natural polyamines and synthetic analogs modify the growth and the morphology of Pyrus communis pollen tubes affecting ROS levels and causing cell death.

V. Tumiatti, A. Minarini, G. Cai, 2015, Plant science : an international journal of experimental plant biology.

Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.

V. Andrisano, M. Bartolini, V. Tumiatti, 2001, Journal of medicinal chemistry.

Synthetic polyamines: an overview of their multiple biological activities

V. Tumiatti, A. Milelli, A. Minarini, 2010, Amino Acids.

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties.

V. Andrisano, M. Bartolini, V. Tumiatti, 2004, Journal of medicinal chemistry.

Polyamines in drug discovery: from the universal template approach to the multitarget-directed ligand design strategy.

V. Tumiatti, A. Minarini, M. Rosini, 2010, Journal of medicinal chemistry.

Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.

M L Bolognesi, A. Cavalli, V. Andrisano, 1998, Journal of medicinal chemistry.

Recent Advances in α1-Adrenoreceptor Antagonists as Pharmacological Tools and Therapeutic Agents

V. Tumiatti, A. Minarini, M. Rosini, 2007 .

Recent advances in alpha1-adrenoreceptor antagonists as pharmacological tools and therapeutic agents.

V. Tumiatti, A. Minarini, M. Rosini, 2007, Current topics in medicinal chemistry.

Tacrine-based Multifunctional Agents in Alzheimer's Disease: An Old Story in Continuous Development§.

V. Andrisano, V. Tumiatti, A. Milelli, 2017, Current medicinal chemistry.

Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.

Maurizio Recanatini, Maria Laura Bolognesi, Andrea Cavalli, 2007, Journal of medicinal chemistry.

Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer’s Disease Multitarget Drug Discovery?

V. Andrisano, V. Tumiatti, A. Milelli, 2020, Journal of medicinal chemistry.

Novel polyamine-based Histone deacetylases-Lysine demethylase 1 dual binding inhibitors.

V. Tumiatti, A. Milelli, A. Minarini, 2018, Bioorganic & medicinal chemistry letters.

Synthesis of monomeric derivatives to probe memoquin's bivalent interactions.

A. Cavalli, V. Andrisano, G. Bottegoni, 2011, Journal of medicinal chemistry.

Synthetic polyamines as potential amine oxidase inhibitors: a preliminary study

V. Tumiatti, A. Milelli, A. Minarini, 2012, Amino Acids.

An Improved Synthesis of N,N′-Bis(6-(o-Methoxyphenylmethylamino)hexyl)-1,8-octanediamine (Methoctramine).

V. Tumiatti, A. Minarini, C. Melchiorre, 1990 .

An improved synthesis of N,N'-bis[6-o-methoxyphenyl methyl hexylamino]1,8-octanediamine (methoctramine)

V. Tumiatti, A. Minarini, C. Melchiorre, 1989 .

Preparation, characterization and in vitro evaluation of sterically stabilized liposome containing a naphthalenediimide derivative as anticancer agent

V. Tumiatti, A. Milelli, A. Minarini, 2015, Drug delivery.

Exploiting RNA as a new biomolecular target for synthetic polyamines.

V. Tumiatti, A. Milelli, A. Minarini, 2013, Gene.

Cytotoxicity of methoctramine and methoctramine-related polyamines.

Anna Minarini, Vincenzo Tumiatti, Carlo Melchiorre, 2009, Chemico-biological interactions.

Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update

Maria Laura Bolognesi, Anna Minarini, Vincenzo Tumiatti, 2008 .

Recent advances in the design and synthesis of prazosin derivatives

V. Tumiatti, A. Minarini, M. Bolognesi, 2006, Expert opinion on drug discovery.

Stereoselectivity at alpha-adrenoreceptor subtypes: observations with the enantiomers of WB 4101 separated through their amides of N-tosyl-(S)-proline.

V. Andrisano, V. Tumiatti, C. Melchiorre, 1992, Chirality.

Capillary electrophoretic and high-performance liquid chromatographic studies of the enantioselective separation of alpha1-adrenoreceptor antagonists.

R. Gotti, V. Andrisano, V. Cavrini, 1998, Journal of chromatography. A.

A. Cavalli, R. Gotti, M. Recanatini, 1999, Journal of medicinal chemistry.

[4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]-trimethylammonium (McN-A-343)-related compounds. Effect of the butynyl chain inclusion into an aromatic unit on the potency for muscarinic receptors.

A. Cavalli, V. Andrisano, M. Recanatini, 2000, Bioorganic & medicinal chemistry.

Methoctramine analogues inhibit responses to capsaicin and protons in rat dorsal root ganglion neurons.

V. Tumiatti, A. Minarini, M. Rosini, 2004, European journal of pharmacology.

Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases.

V. Tumiatti, A. Milelli, A. Minarini, 2013, European journal of medicinal chemistry.

Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists.

V. Tumiatti, A. Minarini, M. Bolognesi, 1998, Journal of medicinal chemistry.

Muscarinic Properties of Compounds Related to Arecaidine Propargyl Ester

V. Tumiatti, E. Mutschler, U. Moser, 2000, Arzneimittelforschung.

Progress in acetylcholinesterase inhibitors for Alzheimer’s disease

V. Tumiatti, A. Minarini, M. Bolognesi, 2006 .

Lipoic acid, a lead structure for multi-target-directed drugs for neurodegeneration.

V. Tumiatti, A. Minarini, M. Bolognesi, 2006, Mini reviews in medicinal chemistry.

From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease.

V. Tumiatti, A. Minarini, M. Rosini, 2008, Mini reviews in medicinal chemistry.

Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate.

V. Tumiatti, A. Milelli, A. Minarini, 2016, European journal of medicinal chemistry.

Naphthalene diimide-polyamine hybrids as antiproliferative agents: Focus on the architecture of the polyamine chains.

V. Tumiatti, A. Milelli, A. Minarini, 2017, European journal of medicinal chemistry.

Cytotoxicity of methoctramine and methoctramine-related polyamines.

V. Tumiatti, A. Milelli, A. Minarini, 2009, Chemico-biological interactions.

Tumor vascular targeted liposomal-bortezomib minimizes side effects and increases therapeutic activity in human neuroblastoma.

V. Tumiatti, A. Milelli, A. Minarini, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Synthetic polyamines as potential amine oxidase inhibitors: a preliminary study

V. Tumiatti, A. Milelli, A. Minarini, 2011, Amino Acids.