A. Milelli

发表

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.

A. Cavalli, V. Andrisano, M. Bartolini, 2008, Journal of medicinal chemistry.

Structure-activity relationships of novel substituted naphthalene diimides as anticancer agents.

V. Tumiatti, A. Milelli, A. Minarini, 2012, European journal of medicinal chemistry.

Tumor vascular targeted liposomal-bortezomib minimizes side effects and increases therapeutic activity in human neuroblastoma.

V. Tumiatti, A. Milelli, A. Minarini, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Application of an ESI‐QTOF method for the detailed characterization of GSK‐3&bgr; inhibitors

V. Andrisano, V. Tumiatti, A. Milelli, 2017, Journal of pharmaceutical and biomedical analysis.

Direct determination of GSK-3β activity and inhibition by UHPLC-UV-vis diode arrays detector (DAD).

V. Andrisano, A. Milelli, M. Naldi, 2016, Journal of pharmaceutical and biomedical analysis.

Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer’s disease treatment

V. Andrisano, M. Bartolini, V. Tumiatti, 2012, Neuropharmacology.

Tacrine derivatives and Alzheimer's disease.

V. Tumiatti, A. Milelli, A. Minarini, 2010, Current medicinal chemistry.

Oxidative stress in Alzheimer's disease: are we connecting the dots?

A. Milelli, A. Minarini, M. Rosini, 2014, Journal of medicinal chemistry.

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer.

V. Andrisano, V. Tumiatti, A. Milelli, 2020, European journal of medicinal chemistry.

Overview of the Anticancer Profile of Avenanthramides from Oat

A. Milelli, C. Fimognari, C. Calcabrini, 2019, International journal of molecular sciences.

Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death

A. Milelli, L. Altucci, A. Nebbioso, 2018, ChemMedChem.

Exploring the effects of isothiocyanates on chemotherapeutic drugs

V. Tumiatti, A. Milelli, A. Minarini, 2014, Expert opinion on drug metabolism & toxicology.

Deuterium Incorporation Protects Cells from Oxidative Damage

A. Milelli, A. Mazzanti, C. Fimognari, 2019, Oxidative medicine and cellular longevity.

Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One

A. Milelli, M. Bolognesi, Francesca Seghetti, 2022, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of new naphtalene diimides bearing isothiocyanate functionality.

V. Tumiatti, A. Milelli, A. Minarini, 2012, European journal of medicinal chemistry.

Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties.

V. Tumiatti, A. Milelli, A. Minarini, 2007, Bioorganic & medicinal chemistry.

Bovine Serum Amine Oxidase and Polyamine Analogues: Chemical Synthesis and Biological Evaluation Integrated with Molecular Docking and 3-D QSAR Studies

V. Tumiatti, A. Milelli, A. Minarini, 2022, J. Chem. Inf. Model..

Multifunctional tacrine derivatives in Alzheimer's disease.

V. Tumiatti, A. Milelli, A. Minarini, 2013, Current topics in medicinal chemistry.

Transglutaminases, neuronal cell death and neural repair: implications for traumatic brain injury and therapeutics.

A. Milelli, M. Basso, 2019, Current opinion in neurology.

Novel Polyamine–Naphthalene Diimide Conjugates Targeting Histone Deacetylases and DNA for Cancer Phenotype Reprogramming

A. Milelli, A. Minarini, E. Giordano, 2017, ACS medicinal chemistry letters.

Macrocyclic naphthalene diimides as G-quadruplex binders.

Stephan A. Ohnmacht, V. Tumiatti, A. Milelli, 2015, Bioorganic & medicinal chemistry.

Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease.

E. Novellino, V. Andrisano, V. Tumiatti, 2019, ACS medicinal chemistry letters.

Bis(7)‐tacrine Derivatives as Multitarget‐Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities

V. Andrisano, M. Bartolini, V. Tumiatti, 2010, ChemMedChem.

Study of the Cytotoxic Effects of the New Synthetic Isothiocyanate CM9 and Its Fullerene Derivative on Human T-Leukemia Cells

M. Prato, V. Tumiatti, A. Milelli, 2015, Toxins.

How to make five contiguous stereocenters in one reaction: asymmetric organocatalytic synthesis of pentasubstituted cyclohexanes.

A. Milelli, K. Jørgensen, Efraím Reyes, 2007, Angewandte Chemie.

Synthetic polyamines activating autophagy: effects on cancer cell death.

V. Tumiatti, A. Milelli, A. Minarini, 2013, European journal of medicinal chemistry.

Targeted Protein Degradation for Infectious Diseases: from Basic Biology to Drug Discovery

A. Milelli, M. Bolognesi, A. Ilari, 2022, ACS bio & med chem Au.

Perspectives in Designing Multifunctional Molecules in Antipsychotic Drug Discovery

A. Milelli, C. Fimognari, E. Catanzaro, 2016, Drug development research.

Organocatalytic asymmetric synthesis of alpha,alpha-disubstituted alpha-amino acids and derivatives.

A. Milelli, K. Jørgensen, Efraím Reyes, 2008, Journal of the American Chemical Society.

Asymmetric 1,4-addition of oxazolones to nitroalkenes by bifunctional cinchona alkaloid thiourea organocatalysts: synthesis of alpha,alpha-disubstituted alpha-amino acids.

A. Milelli, K. Jørgensen, Efraím Reyes, 2008, Chemistry.

Asymmetric Organocatalysis: A Survival Guide to Medicinal Chemists

A. Milelli, Liher Prieto, Efraím Reyes, 2022, Molecules.

Organocatalytic Asymmetric Synthesis of a,a-Disubstituted a-Amino Acids and Derivatives

A. Milelli, K. Jørgensen, Efraím Reyes, 2009 .

Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate.

V. Tumiatti, A. Milelli, A. Minarini, 2016, European journal of medicinal chemistry.

Asymmetric 1,4-Addition of Oxazolones to Nitroalkenes by Bifunctional Cinchona Alkaloid Thiourea Organocatalysts: Synthesis of α,α-Disubstituted α-Amino Acids.

A. Milelli, Efraím Reyes, J. Alemán, 2009 .

Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent.

V. Tumiatti, A. Milelli, A. Minarini, 2009, Journal of medicinal chemistry.

Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.

V. Andrisano, M. Bartolini, A. Milelli, 2011, European journal of medicinal chemistry.

Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease.

V. Andrisano, M. Bartolini, A. Milelli, 2017, European journal of medicinal chemistry.

Distinct biological responses of metastatic castration resistant prostate cancer cells upon exposure to G-quadruplex interacting naphthalenediimide derivatives.

A. Milelli, A. Minarini, N. Zaffaroni, 2019, European journal of medicinal chemistry.

Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase

A. Milelli, A. Minarini, M. Rosini, 2019, Journal of enzyme inhibition and medicinal chemistry.

Synthetic polyamines: an overview of their multiple biological activities

V. Tumiatti, A. Milelli, A. Minarini, 2010, Amino Acids.

Benextramine and derivatives as novel human monoamine oxidases inhibitors: an integrated approach

A. Milelli, A. Minarini, M. Rosini, 2019, The FEBS journal.

Treatment with a GSK-3β/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of CDKL5 Deficiency Disorder

A. Milelli, E. Ciani, S. Trazzi, 2021, International journal of molecular sciences.

Tacrine-based Multifunctional Agents in Alzheimer's Disease: An Old Story in Continuous Development§.

V. Andrisano, V. Tumiatti, A. Milelli, 2017, Current medicinal chemistry.

Investigating in Vitro Amyloid Peptide 1–42 Aggregation: Impact of Higher Molecular Weight Stable Adducts

V. Andrisano, M. Bartolini, A. Milelli, 2019, ACS omega.

Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer’s Disease Multitarget Drug Discovery?

V. Andrisano, V. Tumiatti, A. Milelli, 2020, Journal of medicinal chemistry.

Novel polyamine-based Histone deacetylases-Lysine demethylase 1 dual binding inhibitors.

V. Tumiatti, A. Milelli, A. Minarini, 2018, Bioorganic & medicinal chemistry letters.

Synthetic polyamines as potential amine oxidase inhibitors: a preliminary study

V. Tumiatti, A. Milelli, A. Minarini, 2012, Amino Acids.

Preparation, characterization and in vitro evaluation of sterically stabilized liposome containing a naphthalenediimide derivative as anticancer agent

V. Tumiatti, A. Milelli, A. Minarini, 2015, Drug delivery.

Exploiting RNA as a new biomolecular target for synthetic polyamines.

V. Tumiatti, A. Milelli, A. Minarini, 2013, Gene.

Cytotoxicity of methoctramine and methoctramine-related polyamines.

Anna Minarini, Vincenzo Tumiatti, Carlo Melchiorre, 2009, Chemico-biological interactions.

Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update

Maria Laura Bolognesi, Anna Minarini, Vincenzo Tumiatti, 2008 .

Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery?

A. Milelli, A. De Simone, 2019, ChemMedChem.

Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases.

V. Tumiatti, A. Milelli, A. Minarini, 2013, European journal of medicinal chemistry.

Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate.

V. Tumiatti, A. Milelli, A. Minarini, 2016, European journal of medicinal chemistry.

Naphthalene diimide-polyamine hybrids as antiproliferative agents: Focus on the architecture of the polyamine chains.

V. Tumiatti, A. Milelli, A. Minarini, 2017, European journal of medicinal chemistry.

Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity.

Maria Laura Bolognesi, Vincenza Andrisano, Fabiana Morroni, 2011, Bioorganic & medicinal chemistry letters.

Cytotoxicity of methoctramine and methoctramine-related polyamines.

V. Tumiatti, A. Milelli, A. Minarini, 2009, Chemico-biological interactions.

From Monoamine Oxidase Inhibition to Antiproliferative Activity: New Biological Perspectives for Polyamine Analogs

A. Milelli, A. Minarini, M. Cervelli, 2023, Molecules.

Oxidative stress in Alzheimer's disease: are we connecting the dots?

A. Milelli, A. Minarini, M. Rosini, 2014, Journal of medicinal chemistry.

PROTAC-Induced Glycogen Synthase Kinase 3β Degradation as a Potential Therapeutic Strategy for Alzheimer’s Disease

V. Andrisano, A. Milelli, M. Bolognesi, 2023, ACS chemical neuroscience.

Tumor vascular targeted liposomal-bortezomib minimizes side effects and increases therapeutic activity in human neuroblastoma.

V. Tumiatti, A. Milelli, A. Minarini, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Synthetic polyamines as potential amine oxidase inhibitors: a preliminary study

V. Tumiatti, A. Milelli, A. Minarini, 2011, Amino Acids.

Pollutants and Drugs: Interactions and Human Health

V. Tumiatti, A. Milelli, C. Fimognari, 2018 .