M. Rosini

发表

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.

A. Cavalli, V. Andrisano, M. Bartolini, 2008, Journal of medicinal chemistry.

Alzheimer's disease: new approaches to drug discovery.

A. Minarini, M. Rosini, M. Bolognesi, 2009, Current opinion in chemical biology.

Structure-activity relationships of novel substituted naphthalene diimides as anticancer agents.

V. Tumiatti, A. Milelli, A. Minarini, 2012, European journal of medicinal chemistry.

Multitarget-directed ligands: innovative chemical probes and therapeutic tools against Alzheimer's disease.

V. Tumiatti, A. Minarini, M. Rosini, 2011, Current topics in medicinal chemistry.

Multi-target-directed ligands to combat neurodegenerative diseases.

Maurizio Recanatini, Maria Laura Bolognesi, Andrea Cavalli, 2008, Journal of medicinal chemistry.

Curcumin in Alzheimer's disease: Can we think to new strategies and perspectives for this molecule?

M. Rosini, M. Catanzaro, C. Lanni, 2017, Pharmacological research.

Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer’s disease treatment

V. Andrisano, M. Bartolini, V. Tumiatti, 2012, Neuropharmacology.

Memantine Derivatives as Multitarget Agents in Alzheimer’s Disease

G. Marotta, A. Minarini, M. Rosini, 2020, Molecules.

Tacrine derivatives and Alzheimer's disease.

V. Tumiatti, A. Milelli, A. Minarini, 2010, Current medicinal chemistry.

Alpha 1-adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety.

V. Tumiatti, A. Minarini, M. Rosini, 2000, Pharmaceutica acta Helvetiae.

A. Cavalli, A. Minarini, M. Rosini, 2003, Journal of medicinal chemistry.

Merging memantine and ferulic acid to probe connections between NMDA receptors, oxidative stress and amyloid-β peptide in Alzheimer's disease.

A. Minarini, M. Rosini, M. Catanzaro, 2019, European journal of medicinal chemistry.

Oxidative stress in Alzheimer's disease: are we connecting the dots?

A. Milelli, A. Minarini, M. Rosini, 2014, Journal of medicinal chemistry.

Multitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics.

A. Minarini, M. Rosini, E. Simoni, 2016, Future medicinal chemistry.

Heterocyclic inhibitors of AChE acylation and peripheral sites.

A. Cavalli, V. Andrisano, M. Bartolini, 2005, Farmaco.

Lights and shadows of electrophile signaling: focus on the Nrf2-Keap1 pathway.

A. Minarini, M. Rosini, C. Lanni, 2019, Future medicinal chemistry.

A Nature-Inspired Nrf2 Activator Protects Retinal Explants from Oxidative Stress and Neurodegeneration

M. Rosini, M. Amadio, M. Cammalleri, 2021, Antioxidants.

Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties.

V. Tumiatti, A. Milelli, A. Minarini, 2007, Bioorganic & medicinal chemistry.

Polymethylene tetraamine backbone as template for the development of biologically active polyamines

V. Tumiatti, A. Minarini, M. Rosini, 2003, Medicinal research reviews.

Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra‐amines

V. Tumiatti, A. Minarini, M. Rosini, 2001, British journal of pharmacology.

Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-β aggregation.

A. Cavalli, V. Andrisano, G. Bottegoni, 2017, Future medicinal chemistry.

Multifunctional tacrine derivatives in Alzheimer's disease.

V. Tumiatti, A. Milelli, A. Minarini, 2013, Current topics in medicinal chemistry.

Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics.

V. Tumiatti, A. Minarini, M. Rosini, 2008, Bioorganic & medicinal chemistry.

Bis(7)‐tacrine Derivatives as Multitarget‐Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities

V. Andrisano, M. Bartolini, V. Tumiatti, 2010, ChemMedChem.

MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond.

V. Andrisano, M. Bartolini, V. Tumiatti, 2009, Current pharmaceutical design.

Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα.

N. Osheroff, A. Minarini, M. Rosini, 2017, Bioorganic & medicinal chemistry letters.

Inhibition of β-Amyloid Aggregation in Alzheimer’s Disease: The Key Role of (Pro)electrophilic Warheads

M. Bartolini, A. Minarini, M. Rosini, 2022, ACS medicinal chemistry letters.

NRF2 and PPAR-γ Pathways in Oligodendrocyte Progenitors: Focus on ROS Protection, Mitochondrial Biogenesis and Promotion of Cell Differentiation

M. Rosini, M. Falchi, C. Lanni, 2020, International journal of molecular sciences.

Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors.

A. Cavalli, V. Andrisano, M. Bartolini, 2003, Farmaco.

Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors.

V. Andrisano, M. Rosini, M. Bolognesi, 2006, Bioorganic & medicinal chemistry.

Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists.

P. Usherwood, V. Tumiatti, A. Minarini, 1999, Journal of medicinal chemistry.

Rational approach to discover multipotent anti-Alzheimer drugs.

Vincenza Andrisano, Anna Minarini, Carlo Melchiorre, 2005, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds.

V. Tumiatti, M. Rosini, C. Melchiorre, 2005, Journal of medicinal chemistry.

Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease.

Luca Goldoni, Giovanni Bottegoni, Andrea Cavalli, 2012, Journal of medicinal chemistry.

Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.

Maurizio Recanatini, Maria Laura Bolognesi, Andrea Cavalli, 2007, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues.

A. Cavalli, V. Andrisano, M. Bartolini, 2004, Journal of medicinal chemistry.

Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.

V. Andrisano, M. Bartolini, A. Milelli, 2011, European journal of medicinal chemistry.

Immunomodulators Inspired by Nature: A Review on Curcumin and Echinacea

M. Rosini, M. Catanzaro, C. Lanni, 2018, Molecules.

Controlled iontophoretic delivery in vitro and in vivo of ARN14140 - a multi-target compound for Alzheimer's disease.

Y. Kalia, A. Cavalli, M. Rosini, 2019, Molecular pharmaceutics.

Multi-target Design Strategies in the Context of Alzheimer’s Disease: Acetylcholinesterase Inhibition and NMDA Receptor Antagonism as the Driving Forces

A. Minarini, M. Rosini, C. Melchiorre, 2014, Neurochemical Research.

The Bivalent Ligand Approach as a Tool for Improving the in vitro Anti‐Alzheimer Multitarget Profile of Dimebon

V. Andrisano, M. Bartolini, M. Rosini, 2013, ChemMedChem.

Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.

A. Cavalli, V. Andrisano, M. Bartolini, 2009, Journal of medicinal chemistry.

Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.

David W McClymont, Andrea Cavalli, David W. McClymont, 2008, Journal of medicinal chemistry.

Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.

V. Andrisano, M. Bartolini, V. Tumiatti, 2001, Journal of medicinal chemistry.

Eye-Light on Age-Related Macular Degeneration: Targeting Nrf2-Pathway as a Novel Therapeutic Strategy for Retinal Pigment Epithelium

M. Rosini, M. Catanzaro, C. Lanni, 2020, Frontiers in Pharmacology.

Multi-target Design Strategies in the Context of Alzheimer’s Disease: Acetylcholinesterase Inhibition and NMDA Receptor Antagonism as the Driving Forces

A. Minarini, M. Rosini, C. Melchiorre, 2014, Neurochemical Research.

Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase

A. Milelli, A. Minarini, M. Rosini, 2019, Journal of enzyme inhibition and medicinal chemistry.

Synthetic polyamines: an overview of their multiple biological activities

V. Tumiatti, A. Milelli, A. Minarini, 2010, Amino Acids.

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties.

V. Andrisano, M. Bartolini, V. Tumiatti, 2004, Journal of medicinal chemistry.

Structure-activity relationship and site of binding of polyamine derivatives at the nicotinic acetylcholine receptor.

Y. Liu, P. Usherwood, M. Rosini, 2000, European journal of biochemistry.

Benextramine and derivatives as novel human monoamine oxidases inhibitors: an integrated approach

A. Milelli, A. Minarini, M. Rosini, 2019, The FEBS journal.

Polyamines in drug discovery: from the universal template approach to the multitarget-directed ligand design strategy.

V. Tumiatti, A. Minarini, M. Rosini, 2010, Journal of medicinal chemistry.

Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.

M L Bolognesi, A. Cavalli, V. Andrisano, 1998, Journal of medicinal chemistry.

Recent Advances in α1-Adrenoreceptor Antagonists as Pharmacological Tools and Therapeutic Agents

V. Tumiatti, A. Minarini, M. Rosini, 2007 .

Recent advances in alpha1-adrenoreceptor antagonists as pharmacological tools and therapeutic agents.

V. Tumiatti, A. Minarini, M. Rosini, 2007, Current topics in medicinal chemistry.

Reversible human serum albumin binding of lipocrine: a circular dichroism study.

M. Rosini, C. Bertucci, A. De Simone, 2011, Chirality.

Nature-Inspired Hybrids (NIH) Improve Proteostasis by Activating Nrf2-Mediated Protective Pathways in Retinal Pigment Epithelial Cells

M. Rosini, S. Govoni, M. Amadio, 2022, Antioxidants.

Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.

Maurizio Recanatini, Maria Laura Bolognesi, Andrea Cavalli, 2007, Journal of medicinal chemistry.

Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects.

A. Cavalli, M. Rosini, M. Bolognesi, 2006, Journal of medicinal chemistry.

Synthesis of monomeric derivatives to probe memoquin's bivalent interactions.

A. Cavalli, V. Andrisano, G. Bottegoni, 2011, Journal of medicinal chemistry.

Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer’s Disease

V. Andrisano, M. Bartolini, A. Minarini, 2016, ACS medicinal chemistry letters.

In Vivo Characterization of ARN14140, a Memantine/Galantamine-Based Multi-Target Compound for Alzheimer’s Disease

A. Cavalli, A. Minarini, M. Rosini, 2016, Scientific Reports.

Functionalized Cannabinoid Subtype 2 Receptor Ligands: Fluorescent, PET, Photochromic and Covalent Molecular Probes

M. Rosini, M. Decker, Filippo Basagni, 2020, ChemMedChem.

Nature‐Inspired Multifunctional Ligands: Focusing on Amyloid‐Based Molecular Mechanisms of Alzheimer's Disease

V. Andrisano, M. Bartolini, A. Minarini, 2016, ChemMedChem.

An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512.

A. Minarini, M. Rosini, G. Palermo, 2015, Chemical communications.

Exploiting RNA as a new biomolecular target for synthetic polyamines.

V. Tumiatti, A. Milelli, A. Minarini, 2013, Gene.

Polypharmacology: the rise of multitarget drugs over combination therapies.

M. Rosini, Michela Rosini, 2014, Future medicinal chemistry.

Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update

Maria Laura Bolognesi, Anna Minarini, Vincenzo Tumiatti, 2008 .

A. Cavalli, R. Gotti, M. Recanatini, 1999, Journal of medicinal chemistry.

Quinazoline based α1-adrenoreceptor antagonists with potent antiproliferative activity in human prostate cancer cell lines.

A. Minarini, M. Rosini, M. Naldi, 2017, European journal of medicinal chemistry.

[4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]-trimethylammonium (McN-A-343)-related compounds. Effect of the butynyl chain inclusion into an aromatic unit on the potency for muscarinic receptors.

A. Cavalli, V. Andrisano, M. Recanatini, 2000, Bioorganic & medicinal chemistry.

Methoctramine analogues inhibit responses to capsaicin and protons in rat dorsal root ganglion neurons.

V. Tumiatti, A. Minarini, M. Rosini, 2004, European journal of pharmacology.

Modulation of Keap1/Nrf2/ARE Signaling Pathway by Curcuma- and Garlic-Derived Hybrids

M. Rosini, M. Catanzaro, C. Lanni, 2020, Frontiers in Pharmacology.

Polyamine–Drug Conjugates: Do They Boost Drug Activity?

G. Marotta, A. Minarini, M. Rosini, 2023, Molecules.

Location of the Polyamine Binding Site in the Vestibule of the Nicotinic Acetylcholine Receptor Ion Channel*

P. Usherwood, M. Rosini, M. Bolognesi, 2001, The Journal of Biological Chemistry.

Targeting Cytokine Release Through the Differential Modulation of Nrf2 and NF-κB Pathways by Electrophilic/Non-Electrophilic Compounds

M. Rosini, M. Catanzaro, C. Lanni, 2020, Frontiers in Pharmacology.

Targeting the Nrf2/Amyloid-Beta Liaison in Alzheimer's Disease: A Rational Approach.

M. Bartolini, A. Minarini, M. Rosini, 2017, ACS chemical neuroscience.

Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action.

V. Andrisano, M. Bartolini, M. Rosini, 2009, Bioorganic & medicinal chemistry letters.

Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents.

A. Cavalli, A. Minarini, M. Rosini, 2010, Journal of medicinal chemistry.

Hybrid Lipoic Acid Derivatives to Attack Prion Disease on Multiple Fronts

A. Cavalli, M. Rosini, M. Bolognesi, 2011, ChemMedChem.

Binding of polyamine-containing toxins in the vestibule of the nicotinic acetylcholine receptor ion channel.

P. Usherwood, M. Rosini, M. Bolognesi, 2001, Farmaco.

An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512.

A. Minarini, M. Rosini, G. Palermo, 2015, Chemical communications.

Role of Fyn Kinase Inhibitors in Switching Neuroinflammatory Pathways.

G. Marotta, A. Minarini, M. Rosini, 2021, Current Medicinal Chemistry.

Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties.

G. Bottegoni, M. Bartolini, A. Minarini, 2023, European journal of medicinal chemistry.

Editorial Sp E cial Focu S: Horizon S in ME dicinal cHEM i S try

M. Rosini, 2014 .

From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease.

V. Tumiatti, A. Minarini, M. Rosini, 2008, Mini reviews in medicinal chemistry.

Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity.

Maria Laura Bolognesi, Vincenza Andrisano, Fabiana Morroni, 2011, Bioorganic & medicinal chemistry letters.

Oxidative stress in Alzheimer's disease: are we connecting the dots?

A. Milelli, A. Minarini, M. Rosini, 2014, Journal of medicinal chemistry.

Double Attack to Oxidative Stress in Neurodegenerative Disorders: MAO-B and Nrf2 as Elected Targets

A. Minarini, M. Rosini, C. Lanni, 2023, Molecules.

Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action.

V. Andrisano, M. Bartolini, M. Rosini, 2009, Bioorganic & medicinal chemistry letters.