J. Leppänen

发表

Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone.

Heikki S. Salo, Päivi H Kiviranta, J. Leppänen, 2008, Bioorganic & medicinal chemistry.

Structural studies of acyl esters of entacapone

J. Leppänen, T. Nevalainen, T. Järvinen, 2001 .

Novel Cyclic Phosphate Prodrug Approach for Cytochrome P450-activated Drugs Containing an Alcohol Functionality

J. Leppänen, T. Järvinen, J. Rautio, 2007, Pharmaceutical Research.

Structure-activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion.

J. Leppänen, A. Poso, M. Lahtela-Kakkonen, 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Aflatoxin B1 transfer and metabolism in human placenta.

J. Leppänen, P. Myllynen, K. Vähäkangas, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Lack of increased oxidative stress in catechol-O-methyltransferase (COMT)-deficient mice

J. Leppänen, M. Karayiorgou, J. Gogos, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

N(epsilon)-thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors.

Päivi H Kiviranta, J. Leppänen, S. Kyrylenko, 2009, Journal of medicinal chemistry.

Determination of metformin and its prodrugs in human and rat blood by hydrophilic interaction liquid chromatography.

J. Leppänen, J. Rautio, P. Keski-Rahkonen, 2009, Journal of pharmaceutical and biomedical analysis.

Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin.

J. Leppänen, J. Rautio, J. Vepsäläinen, 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors.

J. Leppänen, A. Poso, T. Laitinen, 2013, Journal of medicinal chemistry.

Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.

J. Leppänen, A. Poso, T. Nevalainen, 2008, Journal of medicinal chemistry.

Systematic in vitro and in vivo study on porous silicon to improve the oral bioavailability of celecoxib.

J. Leppänen, H. Santos, K. Järvinen, 2015, Biomaterials.

Quantitative Insight into the Design of Compounds Recognized by the L‐Type Amino Acid Transporter 1 (LAT1)

J. Leppänen, A. Poso, M. Lahtela-Kakkonen, 2014, ChemMedChem.

Tailored Synthesis of PEGylated Bismuth Nanoparticles for X-ray Computed Tomography and Photothermal Therapy: One-pot, Targeted pyrolysis, and Self-promotion.

J. Leppänen, Tuulia Tynkkynen, J. Töyräs, 2020, ACS applied materials & interfaces.

Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor.

J. Leppänen, M. Lehtonen, J. Rautio, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of a water-soluble prodrug of entacapone.

J. Leppänen, T. Nevalainen, T. Järvinen, 2000, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of 2,4‐dihydropyrano[2,3‐c]pyrazole derivatives as autotaxin inhibitors

J. Leppänen, A. Poso, T. Laitinen, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Screening of Various Hormone‐Sensitive Lipase Inhibitors as Endocannabinoid‐Hydrolyzing Enzyme Inhibitors

Henri Xhaard, Antti Poso, Jukka Leppänen, 2009, ChemMedChem.

The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption.

J. Leppänen, T. Järvinen, Anne Mannila, 2009, Journal of medicinal chemistry.

Erratum to: Design, Synthesis and Brain Uptake of LAT1-Targeted Amino Acid Prodrugs of Dopamine

J. Leppänen, J. Rautio, M. Forsberg, 2013, Pharmaceutical Research.

N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors.

Anu J. Tervo, Päivi H Kiviranta, J. Leppänen, 2007, Bioorganic & medicinal chemistry letters.

Crystal Structure Changes of γ-cyclodextrin After the SEDS Process in Supercritical Carbon Dioxide Affect the Dissolution Rate of Complexed Budesonide

J. Leppänen, K. Järvinen, S. Velaga, 2007, Pharmaceutical Research.

Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase.

J. Leppänen, E. Proschak, S. Auriola, 2018, Bioorganic chemistry.

Prodrug approach for posterior eye drug delivery: synthesis of novel ganciclovir prodrugs and in vitro screening with cassette dosing.

J. Leppänen, A. Urtti, Kati-Sisko Vellonen, 2020, Molecular pharmaceutics.

Absorption Rate Limit Considerations for Oral Phosphate Prodrugs

G. Flynn, J. Leppänen, D. Fleisher, 2003, Pharmaceutical Research.

Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol.

J. Leppänen, T. Nevalainen, Anne Mannila, 2008, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors.

J. Leppänen, T. Nevalainen, C. Fowler, 2009, European journal of medicinal chemistry.

Rational design of novel CYP2A6 inhibitors.

Muluneh M. Fashe, J. Leppänen, R. Tyndale, 2014, Bioorganic & medicinal chemistry.

Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure

J. Leppänen, M. Lehtonen, J. Rautio, 2016, Neurochemical Research.

Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery.

J. Leppänen, J. Rautio, K. Laine, 2011, Molecular pharmaceutics.

Diets rich in whole grains increase betainized compounds associated with glucose metabolism.

Ville Koistinen, Gabriele Riccardi, Marjukka Kolehmainen, 2018, The American journal of clinical nutrition.

Whole grain intake associated molecule 5-aminovaleric acid betaine decreases β-oxidation of fatty acids in mouse cardiomyocytes

J. Leppänen, A. Poso, T. Tuomainen, 2018, Scientific Reports.

Comparative and pharmacophore model for deacetylase SIRT1

Antti Poso, Tuomo Laitinen, Jukka Leppänen, 2006, J. Comput. Aided Mol. Des..

Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET).

Kjeld Hermansen, Marjukka Kolehmainen, Jukka Leppänen, 2019, The American journal of clinical nutrition.

An in silico approach to discovering novel inhibitors of human sirtuin type 2.

Antti Poso, Jukka Leppänen, Tomi Järvinen, 2004, Journal of medicinal chemistry.

High-accuracy mass spectrometry for identification of sulphur-containing bioactive constituents and flavonoids in extracts of Raphanus sativus var. caudatus Alef (Thai rat-tailed radish)

J. Leppänen, M. Lehtonen, J. Rautio, 2017 .

N(epsilon)-Modified lysine containing inhibitors for SIRT1 and SIRT2.

J. Leppänen, T. Suuronen, A. Salminen, 2010, Bioorganic & medicinal chemistry.

Brain uptake of ketoprofen-lysine prodrug in rats.

J. Leppänen, M. Lehtonen, J. Rautio, 2010, International journal of pharmaceutics.

Large neutral amino acid transporter enables brain drug delivery via prodrugs.

J. Leppänen, T. Nevalainen, Anne Mannila, 2008, Journal of medicinal chemistry.

Green and Efficient Esterification Method Using Dried Dowex H+/NaI Approach

J. Leppänen, J. Vepsäläinen, P. Turhanen, 2019, ACS omega.

Discovering inhibitors of human sirtuin type 2: novel structural scaffolds.

Antti Poso, Jukka Leppänen, Anu J. Tervo, 2006, Journal of medicinal chemistry.

Identification of novel CYP2A6 inhibitors by virtual screening.

J. Leppänen, A. Poso, M. Lahtela-Kakkonen, 2011, Bioorganic & medicinal chemistry.

Design, Synthesis and Brain Uptake of LAT1-Targeted Amino Acid Prodrugs of Dopamine

J. Leppänen, J. Rautio, M. Forsberg, 2013, Pharmaceutical Research.

Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats.

J. Leppänen, J. Rautio, K. Laine, 2009, Journal of medicinal chemistry.

Tyrosine–Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7

J. Leppänen, J. Rautio, Juri M. Timonen, 2020, International journal of molecular sciences.

Synthesis and in‐vitro/in‐vivo evaluation of orally administered entacapone prodrugs

J. Leppänen, T. Nevalainen, J. Huuskonen, 2001, The Journal of pharmacy and pharmacology.

Structural effects on free volume distribution in glassy polysulfones: molecular modelling of gas permeability

J. Leppänen, F. Sundholm, Satu Niemelä, 1996 .

N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors.

Anu J. Tervo, Heikki S. Salo, Päivi H Kiviranta, 2006, Journal of medicinal chemistry.

Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2.

Antti Poso, Jukka Leppänen, Tero Huhtiniemi, 2011, Journal of medicinal chemistry.

Design and synthesis of a novel L-dopa-entacapone codrug.

J. Leppänen, T. Nevalainen, J. Gynther, 2002, Journal of Medicinal Chemistry.

Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors.

Antti Poso, Jukka Leppänen, Carsten Wittekindt, 2008, Journal of medicinal chemistry.

In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin.

J. Leppänen, J. Rautio, J. Sirviö, 2012, Journal of pharmaceutical sciences.

Towards Metformin Prodrugs

J. Leppänen, J. Rautio, J. Vepsäläinen, 2008 .

Whole grain intake associated molecule 5-aminovaleric acid betaine decreases β-oxidation of fatty acids in mouse cardiomyocytes

J. Leppänen, A. Poso, T. Tuomainen, 2018, Scientific Reports.

Erratum to: Design, Synthesis and Brain Uptake of LAT1-Targeted Amino Acid Prodrugs of Dopamine

J. Leppänen, J. Rautio, M. Forsberg, 2013, Pharmaceutical Research.