N. Eberhardt

发表

Role of nonexercise activity thermogenesis in resistance to fat gain in humans.

J. Levine, M. Jensen, N. Eberhardt, 1999, Science.

Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cells.

Norman L Eberhardt, N. Eberhardt, Shi-Wen Jiang, 2005, Cancer research.

Intracellular amyloidogenesis by human islet amyloid polypeptide induces apoptosis in COS-1 cells.

N. Eberhardt, H. J. Hiddinga, Norman L. Eberhardt, 1999, The American journal of pathology.

Hormonal and cell-specific regulation of the human growth hormone and chorionic somatomammotropin genes.

N. Eberhardt, S. Jiang, A. Shepard, 1996, Progress in nucleic acid research and molecular biology.

Expression of wild‐type and mutant S20G hIAPP in physiologic knock‐in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance

N. Eberhardt, Y. Kudva, T. Sanke, 2011, Journal of diabetes investigation.

The human growth hormone gene locus: structure, evolution, and allelic variations.

E. Chen, P. Seeburg, N. Eberhardt, 1987, DNA.

Islet Amyloid Polypeptide (lAPP) and Insulin Secretion

N. Eberhardt, P. Butler, T. O’Brien, 1994 .

Islet Amyloid Polypeptide (IAPP) and Insulin Secretion

N. Eberhardt, P. Butler, T. O’Brien, 1994 .

Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy.

N. Eberhardt, T. Miyatsuka, H. Watada, 2014, The Journal of clinical investigation.

Human islet amyloid polypeptide expression in COS-1 cells. A model of intracellular amyloidogenesis.

N. Eberhardt, P. Butler, T. O’Brien, 1995, The American journal of pathology.

A novel assay in vitro of human islet amyloid polypeptide amyloidogenesis and effects of insulin secretory vesicle peptides on amyloid formation.

N. Eberhardt, Y. Kudva, P. Butler, 1998, The Biochemical journal.

Unique Cellular and Mitochondrial Defects Mediate FK506-Induced Islet &bgr;-Cell Dysfunction

Ian R. Lanza, Y. Asmann, K. Nair, 2011, Transplantation.

Structure and evolution of the growth hormone gene family.

N. Eberhardt, W. Miller, 1983, Endocrine reviews.

High resolution loss of heterozygosity mapping of 17p13 in thyroid cancer: Hurthle cell carcinomas exhibit a small 411-kilobase common region of allelic imbalance, probably containing a novel tumor suppressor gene.

B. Delahunt, N. Eberhardt, I. Hay, 2002, The Journal of clinical endocrinology and metabolism.

A human pituitary adenoma cell line proliferates and maintains some differentiated functions following expression of SV40 large T-antigen

B. Scheithauer, N. Eberhardt, X. Qian, 1998 .

Redifferentiation and induction of tumor suppressors miR-122 and miR-375 by the PAX8/PPARγ fusion protein inhibits anaplastic thyroid cancer: a novel therapeutic strategy

N. Eberhardt, H. Reddi, D. Milošević, 2013, Cancer Gene Therapy.

The PAX8/PPARgamma fusion oncoprotein transforms immortalized human thyrocytes through a mechanism probably involving wild-type PPARgamma inhibition.

N. Eberhardt, M. Sahin, I. Hay, 2004, Oncogene.

The PAX8/PPARγ fusion oncoprotein transforms immortalized human thyrocytes through a mechanism probably involving wild-type PPARγ inhibition

N. Eberhardt, M. Sahin, J. G. Powell, 2004, Oncogene.

Expression of a potential metastasis suppressor gene (nm23) in thyroid neoplasms

D. Schaid, N. Eberhardt, D. Farley, 1993, World Journal of Surgery.

Transforming growth factor-beta 1 induces growth inhibition of a human medullary thyroid carcinoma cell line despite an increase in steady state c-myc messenger ribonucleic acid levels.

N. Eberhardt, S. Khosla, M. Oursler, 1994, Endocrinology.

A micro-scale method to isolate DNA-binding proteins suitable for quantitative comparison of expression levels from transfected cells.

N. Eberhardt, S. Jiang, 1995, Nucleic acids research.

Glucocorticoid action: a mechanism involving nuclear and non‐nuclear pathways

N. Eberhardt, E. Widmaier, J. Baxter, 1982, The British journal of dermatology.

Leptin and leptin receptor expression in normal and neoplastic human pituitary: evidence of a regulatory role for leptin on pituitary cell proliferation.

B. Scheithauer, N. Eberhardt, B. Burguera, 1999, The Journal of clinical endocrinology and metabolism.

The Paired Box-8/Peroxisome Proliferator-Activated Receptor-γ Oncogene in Thyroid Tumorigenesis

N. Eberhardt, H. Reddi, B. Mciver, 2007 .

Affinity chromatography of thyroid hormone receptors. Biospecific elution from support matrices, characterization of the partially purified receptor.

N. Eberhardt, J. Baxter, K. Latham, 1981, The Journal of biological chemistry.

Expression and hormonal regulation of the rat growth hormone gene in transfected mouse L cells.

N. Eberhardt, J. Martial, M. Karin, 1984, DNA.

Clustering of the B cell receptor is not required for the apoptotic response.

N. Eberhardt, M. Trujillo, Shi-Wen Jiang, 2003, DNA and cell biology.

Cowden Disease and the PTEN/MMAC1 Gene

N. Eberhardt, B. Mciver, 2002 .

Thyroid hormone receptors and responses.

P. Seeburg, N. Eberhardt, J. Martial, 1979, Recent progress in hormone research.

Differential loss of heterozygosity at 7q31.2 in follicular and papillary thyroid tumors

David I. Smith, N. Eberhardt, I. Hay, 1998, Oncogene.

DNA Binding of TEA/ATTS Domain Factors Is Regulated by Protein Kinase C Phosphorylation in Human Choriocarcinoma Cells*

N. Eberhardt, L. Miller, M. Dong, 2001, The Journal of Biological Chemistry.

Involvement of a Protein Distinct from Transcription Enhancer Factor-1 (TEF-1) in Mediating Human Chorionic Somatomammotropin Gene Enhancer Function through the GT-IIC Enhanson in Choriocarcinoma and COS Cells (*)

N. Eberhardt, S. Jiang, S. Jiang, 1995, The Journal of Biological Chemistry.

CHAPTER 9 – The Molecular Biology of Thyroid Hormone Action

N. Eberhardt, J. Baxter, J. Apriletti, 1980 .

Thyroid hormone receptors. Alteration of hormone-binding specificity.

N. Eberhardt, J. Baxter, J. Ring, 1979, The Journal of biological chemistry.

FHIT and TSG101 in thyroid tumours: aberrant transcripts reflect rare abnormal RNA processing events of uncertain pathogenetic or clinical significance

N. Eberhardt, I. Hay, J. Goellner, 2000, Clinical endocrinology.

Interaction of small nuclear ribonucleoproteins with simian virus 40 in CV-1 cells: is U2 snRNA involved in regulating replication?

N. Eberhardt, J. Baxter, G. Cathala, 1984, DNA.

Evolution of the Growth Hormone Gene Family

N. Eberhardt, J. Baxter, E. Slater, 1986 .

DNA bending by retinoid X receptor-containing retinoid and thyroid hormone receptor complexes

N. Eberhardt, M. Pfahl, X. P. Lu, 1993, Molecular and cellular biology.

Small heat shock proteins inhibit in vitro Aβ1–42 amyloidogenesis

N. Eberhardt, Y. Kudva, P. Butler, 1997 .

Remnant lipoproteins induce endothelial plasminogen activator inhibitor-1.

N. Eberhardt, T. O’Brien, A. Sawka, 2001, Biochemical and biophysical research communications.

Cooperative binding of TEF-1 to repeated GGAATG-related consensus elements with restricted spatial separation and orientation.

N. Eberhardt, S. Khan, S. Jiang, 2000, DNA and cell biology.

3 – Physicochemical Characterization of the Intranuclear Thyroid Hormone Receptor

N. Eberhardt, J. Baxter, J. Apriletti, 1983 .

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

N. Eberhardt, A. Terzic, D. Baker, 2012, Nature Cell Biology.

Thyroid hormone resistance syndrome: correlation of dominant negative activity and location of mutations.

N. Eberhardt, T. Nagaya, J. Jameson, 1993, The Journal of clinical endocrinology and metabolism.

The 5'-flanking sequences of the human growth hormone gene contain a cell-specific control element.

N. Eberhardt, J. Baxter, P. Cattini, 1986, DNA.

Small heat shock proteins inhibit in vitro A beta(1-42) amyloidogenesis.

N. Eberhardt, Y. Kudva, P. Butler, 1997, FEBS letters.

Hormone—receptor interactions in brain: Uptake and binding of thyroid hormone

N. Eberhardt, P. Timiras, T. Valcana, 1976, Psychoneuroendocrinology.

Hormonal domains of response: actions of glucocorticoid and thyroid hormones in regulating pleiotropic responses in cultured cells.

N. Eberhardt, R. Ivarie, J. Morris, 1980, Recent progress in hormone research.

Adenoviral-mediated gene transfer to human adipocytes in vitro, and human adipose tissue ex vivo and rabbit femoral adipose tissue in vivo.

J. Levine, M. Jensen, N. Eberhardt, 1998, Journal of nutritional science and vitaminology.

The human chorionic somatomammotropin enhancers form a composite silencer in pituitary cells in vitro.

N. Eberhardt, S. Jiang, 1997, Molecular endocrinology.

The human growth hormone gene is negatively regulated by triiodothyronine when transfected into rat pituitary tumor cells.

N. Eberhardt, J. Baxter, P. Cattini, 1986, The Journal of biological chemistry.

Triiodothyronine nuclear receptors: an in vitro comparison of the binding of triiodothyronine to nuclei of adult rat liver, cerebral hemisphere, and anterior pituitary.

N. Eberhardt, P. Timiras, T. Valcana, 1978, Endocrinology.

The PAX8/PPAR gamma fusion oncogene as a potential therapeutic target in follicular thyroid carcinoma.

N. Eberhardt, B. Mciver, S. Grebe, 2004, Current drug targets. Immune, endocrine and metabolic disorders.

Regulated expression of chimaeric genes containing the 5'-flanking regions of human growth hormone-related genes in transiently transfected rat anterior pituitary tumor cells.

N. Eberhardt, P. Cattini, 1987, Nucleic acids research.

Analysis of a major human chorionic somatomammotropin gene. Evidence for two functional promoter elements.

N. Eberhardt, J. Baxter, A. Barta, 1984, The Journal of biological chemistry.

Fluorescent rhodamine‐labeled thyroid hormone derivatives

I. Pastan, N. Eberhardt, J. Baxter, 1979, FEBS letters.

Human placental TEF-5 transactivates the human chorionic somatomammotropin gene enhancer.

N. Eberhardt, K. Wu, S. Jiang, 1999, Molecular endocrinology.

Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation.

B. Scheithauer, N. Eberhardt, W. Young, 1993, The Journal of clinical endocrinology and metabolism.

Thyroid Hormone Receptor Interactions with DNA

N. Eberhardt, J. Baxter, M. Norman, 1989 .

A novel dynamin III isoform is up-regulated in the central nervous system in hypothyroidism

N. Eberhardt, B. Mciver, G. Anderson, 2003, International Journal of Developmental Neuroscience.

Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models

N. Eberhardt, Y. Kudva, A. Jahangir, 2011, Laboratory animals.

Malate dehydrogenase, circular dichroism difference spectra of porcine heart mitochondrial and supernatant enzymes, binary enzyme-coenzyme, and ternary enzyme-coenzyme-substrate analog complexes.

N. Eberhardt, R. Wolfe, 1975, The Journal of biological chemistry.

Thyroid gland clonality revisited: the embryonal patch size of the normal human thyroid gland is very large, suggesting X-chromosome inactivation tumor clonality studies of thyroid tumors have to be interpreted with caution.

B. Delahunt, N. Eberhardt, L. Jovanovic, 2003, The Journal of clinical endocrinology and metabolism.

Malate dehydrogenase. XI. Absence of tryptophan in porcine heart mitochondrial enzyme.

N. Eberhardt, R. Wolfe, 1974, Archives of biochemistry and biophysics.

Prenyltransferase from Saccharomyces cerevisiae. Purification to homogeneity and molecular properties.

N. Eberhardt, H. Rilling, N L Eberhardt, 1975, The Journal of biological chemistry.

Photoaffinity labeling of human thyroxine-binding prealbumin with thyroxine and N-(ethyl-2-diazomalonyl)thyroxine.

N. Eberhardt, S. Nordeen, R. Somack, 1982, Biochemistry.

Thyroid hormone responsiveness in human growth hormone-related genes. Possible correlation with receptor-induced DNA conformational changes.

N. Eberhardt, J. Baxter, W. Zhang, 1992, The Journal of biological chemistry.

Human chorionic somatomammotropin and growth hormone gene expression in rat pituitary tumour cells is dependent on proximal promoter sequences.

N. Eberhardt, W. Zhang, P. Cattini, 1989, Nucleic acids research.

Mechanisms of glucocorticoid hormone action.

N. Eberhardt, J. Baxter, P. Cattini, 1986, Advances in experimental medicine and biology.

Growth Hormone Gene Expression: Hormonal Regulation and Tissue-Specific Expression

N. Eberhardt, J. Baxter, P. Cattini, 1988 .

Chromosomal rearrangements and the pathogenesis of differentiated thyroid cancer

N. Eberhardt, H. Reddi, B. Mciver, 2011 .

Cytogenetic Abnormalities Associated with Endocrine Neoplasia

N. Eberhardt, R. Jenkins, S. Grebe, 1997 .

Human chorionic somatomammotropin enhancer function is mediated by cooperative binding of TEF-1 and CSEF-1 to multiple, low-affinity binding sites.

N. Eberhardt, S. Jiang, M. Trujillo, 1997, Molecular endocrinology.

THE GROWTH HORMONE GENE FAMILY: STRUCTURE, EVOLUTION, EXPRESSION, AND REGULATION

N. Eberhardt, M. Karin, J. Baxter, 1982 .

The human growth hormone gene contains a silencer embedded within an Alu repeat in the 3'-flanking region.

N. Eberhardt, M. Trujillo, M. Sakagashira, 2006, Molecular endocrinology.

A simple method for gene phasing using mate pair sequencing

Travis M. Drucker, Claudia Neuhauser, Travis M Drucker, 2014, BMC Medical Genetics.

Adipocyte macrophage colony-stimulating factor is a mediator of adipose tissue growth.

J. Levine, M. Jensen, N. Eberhardt, 1998, The Journal of clinical investigation.

PPARgamma staining as a surrogate for PAX8/PPARgamma fusion oncogene expression in follicular neoplasms: clinicopathological correlation and histopathological diagnostic value.

N. Eberhardt, M. Sahin, T. Sebo, 2005, The Journal of clinical endocrinology and metabolism.

Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers.

N. Eberhardt, Shi-Wen Jiang, K. Podratz, 2005, Gynecologic oncology.

hMLH1 promoter methylation and silencing in primary endometrial cancers are associated with specific alterations in MBDs occupancy and histone modifications.

N. Eberhardt, Shi-Wen Jiang, K. Podratz, 2006, Gynecologic oncology.

Frequent loss of heterozygosity on chromosomes 3p and 17p without VHL or p53 mutations suggests involvement of unidentified tumor suppressor genes in follicular thyroid carcinoma.

N. Eberhardt, H. Drabkin, R. Jenkins, 1997, The Journal of clinical endocrinology and metabolism.

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

N. Eberhardt, A. Terzic, D. Baker, 2008, Nature Cell Biology.

The role of the PAX8/PPARγ fusion oncogene in the pathogenesis of follicular thyroid cancer

N. Eberhardt, H. Reddi, B. Mciver, 2010, Molecular and Cellular Endocrinology.

Optimising restriction enzyme cleavage of DNA derived from archival histopathological samples: an improved HUMARA assay

B. Delahunt, N. Eberhardt, L. Jovanovic, 2003, Pathology.

Distinct genetic changes characterise multifocality and diverse histological subtypes in papillary thyroid carcinoma

B. Delahunt, N. Eberhardt, R. Lea, 2010, Pathology.

RNA sequencing identifies multiple fusion transcripts, differentially expressed genes, and reduced expression of immune function genes in BRAF (V600E) mutant vs BRAF wild-type papillary thyroid carcinoma.

Jennifer M. Carr, Kendall W. Cradic, D. Serie, 2014, The Journal of clinical endocrinology and metabolism.

Mechanisms of glucocorticoid hormone action.

N. Eberhardt, M. Karin, J. Baxter, 1984, Journal of steroid biochemistry.

The primary structure of coho salmon growth hormone and its cDNA.

N. Eberhardt, R. Nishioka, J. Baxter, 1987, General and comparative endocrinology.

Up-regulation of DNA methyltransferase 3B expression in endometrial cancers.

N. Eberhardt, Shi-Wen Jiang, K. Podratz, 2005, Gynecologic oncology.

Human Endometrial Cells DNA Methyltransferase Activity in De novo Downregulate Methyltransferase-3 B Messenger RNA Stability and Histone Deacetylase Inhibitors Decrease DNA

N. Eberhardt, Shi-Wen Jiang, K. Podratz, 2005 .

Preclinical efficacy of the oncolytic measles virus expressing the sodium iodide symporter in iodine non-avid anaplastic thyroid cancer: a novel therapeutic agent allowing noninvasive imaging and radioiodine therapy

N. Eberhardt, S. Russell, H. Reddi, 2012, Cancer Gene Therapy.

Antitumor Activity of VB-111, a Novel Antiangiogenic Virotherapeutic, in Thyroid Cancer Xenograft Mouse Models.

N. Eberhardt, D. Harats, H. Reddi, 2011, Genes & cancer.

FHIT and TSG101 in thyroid tumours: aberrant transcripts reflect rare abnormal RNA processing events of uncertain pathogenetic or clinical significance.

N. Eberhardt, A. Yokomizo, D. Smith, 2000, Clinical endocrinology.

The Role of the PAX8/PPARγ Fusion Oncogene in Thyroid Cancer

N. Eberhardt, H. Reddi, B. Mciver, 2008, PPAR research.

Evaluation of the PAX8/PPARG translocation in follicular thyroid cancer with a 4-color reverse-transcription PCR assay and automated high-resolution fragment analysis.

N. Eberhardt, H. Reddi, D. Milošević, 2010, Clinical chemistry.

ONYX-411, a conditionally replicative oncolytic adenovirus, induces cell death in anaplastic thyroid carcinoma cell lines and suppresses the growth of xenograft tumors in nude mice

N. Eberhardt, J. Copland, E. Galanis, 2008, Cancer Gene Therapy.

The Putative PAX8/PPARγ Fusion Oncoprotein Exhibits Partial Tumor Suppressor Activity through Up-Regulation of Micro-RNA-122 and Dominant-Negative PPARγ Activity.

N. Eberhardt, H. Reddi, D. Milošević, 2011, Genes & cancer.

Expression of the PAX8/PPARγ Fusion Protein Is Associated with Decreased Neovascularization In Vivo: Impact on Tumorigenesis and Disease Prognosis.

N. Eberhardt, J. Copland, L. Marlow, 2010, Genes & cancer.

Loss of heterozygosity studies revisited: prior quantification of the amplifiable DNA content of archival samples improves efficiency and reliability.

B. Delahunt, N. Eberhardt, I. Hay, 2002, The Journal of molecular diagnostics : JMD.

Estrogen receptor expression and growth-promoting function in human choriocarcinoma cells.

N. Eberhardt, L. Jin, R. Lloyd, 1997, DNA and cell biology.

Epigenetic-mediated upregulation of progesterone receptor B gene in endometrial cancer cell lines.

N. Eberhardt, Shi-Wen Jiang, J. Gonzalez Bosquet, 2005, Gynecologic oncology.

Basal, Cell‐Specific and Hormonal Regulation of Gene Transcription: an Overview of the 1980s

N. Eberhardt, 1990, Acta paediatrica Scandinavica. Supplement.

TEF-1 Transrepression in BeWo Cells Is Mediated through Interactions with the TATA-binding Protein, TBP (*)

N. Eberhardt, S. Jiang, Shi-Wen Jiang, 1996, The Journal of Biological Chemistry.

Two CGTCA motifs and a GHF1/Pit1 binding site mediate cAMP-dependent protein kinase A regulation of human growth hormone gene expression in rat anterior pituitary GC cells.

N. Eberhardt, W. Zhang, A. Shepard, 1994, The Journal of biological chemistry.

The human growth hormone gene contains both positive and negative control elements.

N. Eberhardt, J. Baxter, P. Cattini, 1988, The Journal of biological chemistry.

S20G mutant amylin exhibits increased in vitro amyloidogenicity and increased intracellular cytotoxicity compared to wild-type amylin.

N. Eberhardt, T. Sanke, K. Nanjo, 2000, The American journal of pathology.

Effect of butyrate on thyroid hormone-mediated gene expression in rat pituitary tumour cells

E. Kardami, N. Eberhardt, P. Cattini, 1988, Molecular and Cellular Endocrinology.

eNOS gene transfer to vascular smooth muscle cells inhibits cell proliferation via upregulation of p27 and p21 and not apoptosis.

N. Eberhardt, T. O’Brien, L. Fitzpatrick, 2000, Cardiovascular research.

An Initiator Element Is Required for Maximal Human Chorionic Somatomammotropin Gene Promoter and Enhancer Function (*)

N. Eberhardt, A. Shepard, S. Jiang, 1995, The Journal of Biological Chemistry.

Autophagy protects against human islet amyloid polypeptide‐associated apoptosis

N. Eberhardt, T. Sanke, T. Kondo, 2010, Journal of diabetes investigation.

Novel human TEF-1 isoforms exhibit altered DNA binding and functional properties.

N. Eberhardt, R. Wilke, S. Jiang, 2000, Biochemistry.

Interactions of the nuclear thyroid hormone receptor with core histones.

N. Eberhardt, J. Baxter, J. Apriletti, 1984, The Journal of biological chemistry.

Kinetics of the apoptotic response induced by anti-IgM engagement of the B cell receptor is dependent on the density of cell surface immunoglobulin M expression.

N. Eberhardt, M. Trujillo, 2003, DNA and cell biology.

Molecular mechanisms of thyroid hormone action.

N. Eberhardt, A. Shepard, 1993, Clinics in laboratory medicine.

References and Notes Materials and Methods Figs. S1 to S4 Tables S1 and S2 References Sequence-directed Dna Translocation by Purified Ftsk

N. Cozzarelli, C. Bustamante, K. Nair, 2022 .

Most multifocal papillary thyroid carcinomas acquire genetic and morphotype diversity through subclonal evolution following the intra‐glandular spread of the initial neoplastic clone

B. Delahunt, N. Eberhardt, L. Jovanovic, 2008, The Journal of pathology.

Leptin responses to overfeeding: relationship with body fat and nonexercise activity thermogenesis.

J. Levine, M. Jensen, N. Eberhardt, 1999, The Journal of clinical endocrinology and metabolism.

Negative thyroid hormone control of human growth hormone gene expression is mediated by 3'-untranslated/3'-flanking DNA.

N. Eberhardt, J. Baxter, D. Silversides, 1992, The Journal of biological chemistry.