P. Boutin

发表

A genome-wide association study identifies novel risk loci for type 2 diabetes

T. Hudson, D. Balding, A. Montpetit, 2007, Nature.

A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus.

P. Boutin, P. Froguel, A. Philippi, 1998, The Journal of clinical investigation.

Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity

K. Clément, C. Dina, P. Boutin, 2005, Diabetologia.

Common nonsynonymous variants in PCSK1 confer risk of obesity

T. Hansen, O. Pedersen, T. Jørgensen, 2008, Nature Genetics.

Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women.

P. Boutin, P. Froguel, G. Frühbeck, 2006, Biochemical and biophysical research communications.

Genome-Wide Search for Type 2 Diabetes in Japanese Affected Sib-Pairs Confirms Susceptibility Genes on 3 q , 15 q , and 20 q and Identifies Two New Candidate Loci on 7 p and 11 p

C. Dina, P. Boutin, P. Froguel, 2002 .

Anatomy of a Homeoprotein Revealed by the Analysis of Human MODY3 Mutations*

P. Boutin, P. Froguel, M. Vaxillaire, 1999, The Journal of Biological Chemistry.

Is glutamate decarboxylase 2 (GAD2) a genetic link between low birth weight and subsequent development of obesity in children?

P. Boutin, B. Heude, D. Meyre, 2005, The Journal of clinical endocrinology and metabolism.

Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population.

C. Dina, P. Boutin, G. Charpentier, 2006, Diabetes.

Genetics of Pathways Regulating Body Weight in the Development of Obesity in Humans

P. Boutin, P. Froguel, 2001, Experimental biology and medicine.

The INS VNTR locus does not associate with smallness for gestational age (SGA) but interacts with SGA to increase insulin resistance in young adults.

P. Boutin, D. Meyre, P. Froguel, 2006, The Journal of clinical endocrinology and metabolism.

Routine mutation screening of HNF-1α and GCK genes in MODY diagnosis: How effective are the techniques of DHPLC and direct sequencing used in combination?

P. Boutin, F. Vasseur, P. Froguel, 2001, Diabetologia.

Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR ): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians

M. Permutt, P. Boutin, P. Froguel, 1998, Diabetologia.

Automated fluorescence-based screening for mutation by SSCP: use of universal M13 dye primers for labeling and detection.

P. Boutin, F. Vasseur, J. Hager, 1997, BioTechniques.

Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians.

K. Clément, C. Dina, P. Boutin, 2002, Human molecular genetics.

GAD2 on Chromosome 10p12 Is a Candidate Gene for Human Obesity

K. Clément, Å. Lernmark, C. Dina, 2003, PLoS biology.

Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.

C. Dina, P. Boutin, P. Froguel, 2002, Diabetes.

Missense mutation Gly574Ser in the transcription factor HNF-1alpha is a marker of atypical diabetes mellitus in African-American children.

P. Boutin, L. Gresh, G. Bell, 1999, Diabetologia.

Mutation screening in 18 Caucasian families suggest the existence of other MODY genes

P. Boutin, G. Charpentier, P. Froguel, 1998, Diabetologia.

Identification of seven novel nucleotide variants in the hepatocyte nuclear factor‐1α (TCF1) promoter region in MODY patients

P. Boutin, P. Froguel, H. Blanché, 2000, Human mutation.

Obesity susceptibility CART gene polymorphism contributes to bone remodeling in postmenopausal women

C. Christiansen, P. Boutin, P. Froguel, 2005, Osteoporosis International.

Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p.

C. Dina, P. Boutin, P. Froguel, 2002, Diabetes.

An Automated Fluorescent Single-Strand Conformation Polymorphism Technique for Screening Mutations in the Hepatocyte Nuclear Factor-1α Gene (Maturity-Onset Diabetes of the Young)

P. Boutin, P. Froguel, M. Vaxillaire, 1997, Diabetes.

Obesity: Genetics, Behavior or a Combination of Both

P. Boutin, D. Meyre, P. Froguel, 2004 .

Genetics of Obesity

K. Clément, P. Boutin, P. Froguel, 2011, Springer New York.

Genetics of human obesity.

P. Boutin, P. Froguel, P. Froguel, 2001, Best practice & research. Clinical endocrinology & metabolism.

Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians

D. Bonthron, P. Boutin, E. Schaftingen, 2003, Diabetologia.

Genetic studies of neuropeptide Y and neuropeptide Y receptors Y1 and Y5 regions in morbid obesity

G. Gyapay, K. Clément, C. Dina, 1997, Diabetologia.

Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population

K. Clément, F. Horber, C. Dina, 2005, BMC Genetics.

Mutation screening and association studies of the human uncoupling protein 3 gene in normoglycemic and diabetic morbidly obese patients.

K. Clément, P. Boutin, F. Vasseur, 1999, Diabetes.

Linkage and association studies between the proopiomelanocortin (POMC) gene and obesity in caucasian families

K. Clément, C. Dina, P. Boutin, 2000, Diabetologia.

No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians.

P. Boutin, P. Froguel, M. Chikri, 2002, Diabetologia.

Genetic Polymorphisms and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets

Philippe Froguel, Christian Dina, Philippe Boutin, 2006, PLoS clinical trials.

Short Technical Repor t Rapid SNP Allele Frequency Determination in Genomic DNA Pools by Pyrosequencin g

P. Boutin, P. Froguel, V. Vatin, 2002 .

Evaluating the Association of FAAH Common Gene Variation with Childhood, Adult Severe Obesity and Type 2 Diabetes in the French Population

P. Boutin, B. Balkau, G. Charpentier, 2008, Obesity Facts.

The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes

C. Dina, P. Boutin, P. Froguel, 2000, Nature Genetics.

Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes

K. Clément, C. Dina, P. Boutin, 2005, Nature Genetics.

GAD2: a polygenic contribution to genetic susceptibility for common obesity?

P. Boutin, P. Froguel, 2005, Pathologie-biologie.

Rapid SNP allele frequency determination in genomic DNA pools by pyrosequencing.

P. Boutin, P. Froguel, V. Vatin, 2002, BioTechniques.

Prevalence of the missense mutation Gly574Ser in the hepatocyte nuclear factor-1alpha in Africans with diabetes.

P. Boutin, B. Bauduceau, M. Ducorps, 2002, Diabetes & metabolism.

Genotype-by-nutrient interactions assessed in European obese women

O. Pedersen, K. Clément, S. Toubro, 2006, European journal of nutrition.

Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism

A. Mildner, P. Boutin, H. Kettenmann, 2015, Glia.

Mutation screening of the urocortin gene: identification of new single nucleotide polymorphisms and association studies with obesity in French Caucasians.

K. Clément, C. Dina, P. Boutin, 2002, Journal of Clinical Endocrinology and Metabolism.

Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians.

Philippe Froguel, Christian Dina, Philippe Boutin, 2004, Diabetes.

Big Dye™ terminator cycle sequencing chemistry: Accuracy of the dilution process and application for screening mutations in the TCF1 and GCK genes

P. Boutin, F. Vasseur, P. Froguel, 2000, Human mutation.

Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease

P. Boutin, P. Amouyel, V. Mooser, 2003, Molecular Psychiatry.

Genetics of Obesity

K. Clément, P. Boutin, P. Froguel, 2002, American journal of pharmacogenomics : genomics-related research in drug development and clinical practice.

Islet-brain 1/c-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease

P. Boutin, P. Amouyel, V. Mooser, 2003, Molecular Psychiatry.