A. Pshezhetsky

发表

A genome-wide association study identifies novel risk loci for type 2 diabetes

T. Hudson, D. Balding, A. Montpetit, 2007, Nature.

De Novo Mutations in Moderate or Severe Intellectual Disability

Edouard Henrion, Guy A. Rouleau, Fadi F. Hamdan, 2014, PLoS genetics.

Multidimensional Proteomics for the Identification of Endothelial Post Mortem Signals of Importance in Vascular Remodeling

A. Pshezhetsky, I. Sirois, M. Hébert, 2012 .

Apoptosis of endothelial cells triggers a caspase‐dependent anti‐apoptotic paracrine loop active on vascular smooth muscle cells

A. Pshezhetsky, A. Désormeaux, N. Vigneault, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Caspase-3 Activation Triggers Extracellular Cathepsin L Release and Endorepellin Proteolysis*

A. Pshezhetsky, J. Cailhier, R. Iozzo, 2008, Journal of Biological Chemistry.

Caspase activation regulates the extracellular export of autophagic vacuoles

A. Pshezhetsky, N. Pallet, I. Sirois, 2012, Autophagy.

Sialic acid catabolism by N-acetylneuraminate pyruvate lyase is essential for muscle function.

C. Ross, W. Wasserman, A. Pshezhetsky, 2018, JCI insight.

Presence of aberrant epididymal tubules revealing undifferentiated epithelial cells and absence of spermatozoa in a combined neuraminidase-3 and -4 deficient adult mouse model

A. Pshezhetsky, L. Hermo, C. Morales, 2018, PloS one.

Mitochondrial damage and cholesterol storage in human hepatocellular carcinoma cells with silencing of UBIAD1 gene expression

A. Pshezhetsky, Luigi Bruno, C. McMaster, 2014, Molecular Genetics and Metabolism Reports.

Crosstalk between 2 organelles: Lysosomal storage of heparan sulfate causes mitochondrial defects and neuronal death in mucopolysaccharidosis III type C

A. Pshezhetsky, 2015, Rare diseases.

Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway

A. Pshezhetsky, R. Sladek, Y. Xu, 2007, Cell Death and Differentiation.

Serine Carboxypeptidase SCPEP1 and Cathepsin A Play Complementary Roles in Regulation of Vasoconstriction via Inactivation of Endothelin-1

A. Pshezhetsky, J. Tremblay, Junzheng Peng, 2014, PLoS genetics.

Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferative vesicular corneal dystrophy and hypertrophic skin thickenings

A. Pshezhetsky, A. Hinek, Xuefang Pan, 2017, PloS one.

Antagonist of IL-1 Receptor Development of a Novel Noncompetitive

A. Pshezhetsky, N. Heveker, M. Leduc, 2013 .

Molecular Bases of Neurodegeneration and Cognitive Decline, the Major Burden of Sanfilippo Disease

A. Pshezhetsky, Rachel Heon-Roberts, Annie L A Nguyen, 2020, Journal of clinical medicine.

Cathepsin B-associated Activation of Amyloidogenic Pathway in Murine Mucopolysaccharidosis Type I Brain Cortex

A. Pshezhetsky, H. Nader, V. D’Almeida, 2020, International journal of molecular sciences.

Where catabolism meets signalling: neuraminidase 1 as a modulator of cell receptors

A. Pshezhetsky, A. Hinek, 2011, Glycoconjugate Journal.

Analysis of the Biogenesis of Heparan Sulfate Acetyl-CoA:α-Glucosaminide N-Acetyltransferase Provides Insights into the Mechanism Underlying Its Complete Deficiency in Mucopolysaccharidosis IIIC*

A. Pshezhetsky, P. Thibault, É. Bonneil, 2010, The Journal of Biological Chemistry.

Lysosomal Carboxypeptidase A

A. Pshezhetsky, 2013 .

Anatomical changes and pathophysiology of the brain in mucopolysaccharidosis disorders.

A. Pshezhetsky, D. Begley, B. Bigger, 2018, Molecular genetics and metabolism.

Persistent reduction in sialylation of cerebral glycoproteins following postnatal inflammatory exposure

Wyston C Pierre, A. Pshezhetsky, G. Lodygensky, 2018, Journal of Neuroinflammation.

Enzymatic Activity of Lysosomal Carboxypeptidase (Cathepsin) A Is Required for Proper Elastic Fiber Formation and Inactivation of Endothelin-1

A. Pshezhetsky, J. Tremblay, Junzheng Peng, 2008, Circulation.

Regulation of Phagocytosis in Macrophages by Neuraminidase 1*

A. Pshezhetsky, E. Kanshin, M. Szewczuk, 2009, The Journal of Biological Chemistry.

Neuraminidases 1 and 3 Trigger Atherosclerosis by Desialylating Low‐Density Lipoproteins and Increasing Their Uptake by Macrophages

A. Orekhov, A. Pshezhetsky, R. Roy, 2021, Journal of the American Heart Association.

Molecular mechanism of lysosomal sialidase deficiency in galactosialidosis involves its rapid degradation.

K. Lukong, A. Pshezhetsky, M. El‐Alfy, 1998, The Biochemical journal.

Association of N-acetylgalactosamine-6-sulfate sulfatase with the multienzyme lysosomal complex of beta-galactosidase, cathepsin A, and neuraminidase. Possible implication for intralysosomal catabolism of keratan sulfate.

A. Pshezhetsky, M. Potier, 1996, The Journal of biological chemistry.

Neu4, a Novel Human Lysosomal Lumen Sialidase, Confers Normal Phenotype to Sialidosis and Galactosialidosis Cells*

A. Pshezhetsky, C. Morales, K. Landry, 2004, Journal of Biological Chemistry.

Desialylation of insulin receptors and IGF-1 receptors by neuraminidase-1 controls the net proliferative response of L6 myoblasts to insulin.

A. Pshezhetsky, A. Hinek, Yanting Wang, 2010, Glycobiology.

The Janus‐like role of neuraminidase isoenzymes in inflammation

A. Pshezhetsky, C. Cairo, Md. Amran Howlader, 2021, bioRxiv.

Lysosomal Sialidase (Neuraminidase-1) Is Targeted to the Cell Surface in a Multiprotein Complex That Facilitates Elastic Fiber Assembly*

A. Pshezhetsky, M. von Itzstein, B. Starcher, 2006, Journal of Biological Chemistry.

Sanfilippo type C disease: pathogenic mechanism and potential therapeutic applications

A. Pshezhetsky, Carla Martins, M. Ashmarina, 2018, Expert Opinion on Orphan Drugs.

Atypical juvenile presentation of GM2 gangliosidosis AB in a patient compound-heterozygote for c.259G > T and c.164C > T mutations in the GM2A gene☆

A. Pshezhetsky, G. Mitchell, A. Lortie, 2017, Molecular genetics and metabolism reports.

An acetylated 120-kDa lysosomal transmembrane protein is absent from mucopolysaccharidosis IIIC fibroblasts: a candidate molecule for MPS IIIC.

A. Pshezhetsky, K. Landry, F. Lapointe, 2006, Molecular genetics and metabolism.

Molecular pathology of NEU1 gene in sialidosis

A. Pshezhetsky, R. Froissart, M. Zabot, 2003, Human mutation.

Hyaluronidase 1 and β-Hexosaminidase Have Redundant Functions in Hyaluronan and Chondroitin Sulfate Degradation*♦

A. Pshezhetsky, D. Martin, B. Triggs-Raine, 2012, Journal of Biological Chemistry.

Proteome Analysis and Functional Expression Identify Mortalin as an Antiapoptotic Gene Induced by Elevation of [Na Ratio in Cultured Vascular Smooth Muscle Cells Cellular Biology

A. Pshezhetsky, P. Thibault, S. Orlov, 2002 .

Monocyte Differentiation Up-regulates the Expression of the Lysosomal Sialidase, Neu1, and Triggers Its Targeting to the Plasma Membrane via Major Histocompatibility Complex Class II-positive Compartments*

Ali Ahmad, Rasheed Ahmad, A. Pshezhetsky, 2006, Journal of Biological Chemistry.

Lysosomal multienzyme complex: biochemistry, genetics, and molecular pathophysiology.

A. Pshezhetsky, M. Ashmarina, 2001, Progress in nucleic acid research and molecular biology.

Identification of UDP-N-acetylglucosamine-phosphotransferase-binding sites on the lysosomal proteases, cathepsins A, B, and D.

K. Lukong, A. Pshezhetsky, M. Elsliger, 1999, Biochemistry.

Keeping it trim: roles of neuraminidases in CNS function

A. Pshezhetsky, M. Ashmarina, 2018, Glycoconjugate Journal.

Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model.

A. Pshezhetsky, E. Hamel, M. Tesařová, 2015, Brain : a journal of neurology.

Selective Inhibitors of Human Neuraminidase 3.

A. Pshezhetsky, B. Ernst, A. Fougerat, 2018, Journal of medicinal chemistry.

Spectral optical coherence tomography in a patient with type I sialidosis

A. Pshezhetsky, Z. Michalewska, J. Michalewski, 2011, Medical science monitor : international medical journal of experimental and clinical research.

Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages

A. Pshezhetsky, Lai-Xi Wang, A. Cross, 2005, The FEBS journal.

Direct affinity purification and supramolecular organization of human lysosomal cathepsin A.

A. Pshezhetsky, M. Potier, 1994, Archives of biochemistry and biophysics.

Stoichiometry of the Human Lysosomal Carboxypeptidase-β-Galactosidase Complex

A. Pshezhetsky, M. Potier, 1993 .

Protein Misfolding as an Underlying Molecular Defect in Mucopolysaccharidosis III Type C

A. Pshezhetsky, S. Durand, M. Feldhammer, 2009, PloS one.

Continuous spectrophotometric assay of human lysosomal cathepsin A/protective protein in normal and galactosialidosis cells.

A. Pshezhetsky, M. Elsliger, M. Potier, 1995, Analytical biochemistry.

Desialylation of surface receptors as a new dimension in cell signaling

A. Pshezhetsky, L. Ashmarina, Alexey V. Pshezhetsky, 2013, Biochemistry (Moscow).

HGSNAT enzyme deficiency results in accumulation of heparan sulfate in podocytes and basement membranes.

A. Pshezhetsky, C. Morales, Regiana L. Oliveira, 2019, Histology and histopathology.

Enzymes entrapped in reversed micelles of surfactants in organic solvents: A theoretical treatment of the catalytic activity regulation

A. Pshezhetsky, K. Martínek, A. Kabanov, 1988 .

Dominant Role for Calpain in Thromboxane-Induced Neuromicrovascular Endothelial Cytotoxicity

A. Pshezhetsky, P. Hardy, I. Lahaie, 2006, Journal of Pharmacology and Experimental Therapeutics.

Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3Kγ pathway.

A. Pshezhetsky, L. Martiny, L. Duca, 2014, Cardiovascular research.

Lysosomal storage of heparan sulfate causes mitochondrial defects, altered autophagy, and neuronal death in the mouse model of mucopolysaccharidosis III type C

A. Pshezhetsky, 2016, Autophagy.

Catalysis by enzymes entrapped into hydrated surfactant aggregates having lamellar or cylindrical (hexagonal) or ball-shaped (cubic) structure in organic solvents.

A. Pshezhetsky, K. Martínek, N. Klyachko, 1986, European journal of biochemistry.

Molecular Pathology of NEU 1 Gene in Sialidosis

A. Pshezhetsky, R. Froissart, M. Zabot, 2003 .

Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups

Matthew B. Tessier, A. Pshezhetsky, A. Varki, 2012, The Journal of Biological Chemistry.

Selective Inhibitors of Human Neuraminidase 1 (NEU1).

A. Pshezhetsky, C. Cairo, Tianlin Guo, 2018, Journal of medicinal chemistry.

Alcohol dehydrogenase (ADH) Influence of homo‐ and heterologous ADH administration on albino rats craving for alcohol and on ADH isozyme activity in the liver

A. Pshezhetsky, A. V. Pshezhetsky, I. Ashmarin, 1992, FEBS letters.

Proteome Analysis and Functional Expression Identify Mortalin as an Antiapoptotic Gene Induced by Elevation of [Na+]i/[K+]i Ratio in Cultured Vascular Smooth Muscle Cells

A. Pshezhetsky, P. Thibault, S. Orlov, 2002, Circulation research.

Clinical variability of type II sialidosis by C808T mutation

A. Pshezhetsky, G. Rodríguez Criado, I. Gómez de Terreros, 2003, American journal of medical genetics. Part A.

Novel missense mutations in the human lysosomal sialidase gene in sialidosis patients and prediction of structural alterations of mutant enzymes

A. Pshezhetsky, H. Doi, J. Kira, 2002, Journal of Human Genetics.

Mutations in Sialidosis Impair Sialidase Binding to the Lysosomal Multienzyme Complex*

K. Lukong, A. Pshezhetsky, M. Elsliger, 2001, The Journal of Biological Chemistry.

Molecular and structural studies of Japanese patients with sialidosis type 1

K. Lukong, A. Pshezhetsky, H. Doi, 2000, Journal of Human Genetics.

Characterization of the sialidase molecular defects in sialidosis patients suggests the structural organization of the lysosomal multienzyme complex.

K. Lukong, A. Pshezhetsky, G. Thomas, 2000, Human molecular genetics.

Cloning, expression and chromosomal mapping of human lysosomal sialidase and characterization of mutations in sialidosis

Daniel Leclerc, Marc-André Elsliger, A. Pshezhetsky, 1997, Nature Genetics.

Novel Direct Assay for Acetyl-CoA:α-Glucosaminide N-Acetyltransferase Using BODIPY-Glucosamine as a Substrate.

A. Pshezhetsky, N. Bovin, A. Tuzikov, 2015, JIMD reports.

Mutations in TMEM76* cause mucopolysaccharidosis IIIC (Sanfilippo C syndrome).

T. Hudson, A. Verner, A. Pshezhetsky, 2006, American journal of human genetics.

3-Hydroxy-3-methylglutaryl coenzyme A lyase: targeting and processing in peroxisomes and mitochondria.

A. Pshezhetsky, G. Mitchell, S. Branda, 1999, Journal of lipid research.

Gene expression profiles of normal proliferating and differentiating human intestinal epithelial cells: A comparison with the Caco‐2 cell model

A. Pshezhetsky, E. Levy, E. Seidman, 2006, Journal of cellular biochemistry.

Mutations in TMEM76* Cause Mucopolysaccharidosis IIIC

T. Hudson, A. Verner, A. Pshezhetsky, 2006 .

Positive Regulation of Insulin Signaling by Neuraminidase 1

A. Pshezhetsky, P. Thibault, N. Heveker, 2013, Diabetes.

Subcellular proteomics of cell differentiation: Quantitative analysis of the plasma membrane proteome of Caco‐2 cells

D. Labuda, A. Pshezhetsky, E. Levy, 2007, Proteomics.

Global analysis of protein phosphorylation networks in insulin signaling by sequential enrichment of phosphoproteins and phosphopeptides.

A. Pshezhetsky, B. Posner, Yanqing Xu, 2012, Molecular bioSystems.

Molecular characterization of a large group of Mucopolysaccharidosis type IIIC patients reveals the evolutionary history of the disease

D. Labuda, A. Pshezhetsky, R. Giugliani, 2019, Human mutation.

Therapeutic strategies based on modified U1 snRNAs and chaperones for Sanfilippo C splicing mutations

A. Pshezhetsky, M. Prata, P. Jordan, 2014, Orphanet Journal of Rare Diseases.

The stoichiometry of protein phosphorylation in adipocyte lipid droplets: Analysis by N‐terminal isotope tagging and enzymatic dephosphorylation

A. Pshezhetsky, E. Kanshin, Shupei Wang, 2009, Proteomics.

Quantitative analysis of a proteome by N-terminal stable-isotope labelling of tryptic peptides.

A. Pshezhetsky, E. Levy, B. Posner, 2007, Rapid communications in mass spectrometry : RCM.

Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues.

A. Pshezhetsky, C. Cairo, Amgad Albohy, 2013, Journal of medicinal chemistry.

Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT

A. Pshezhetsky, Y. Yamanaka, D. Priestman, 2022, The Journal of experimental medicine.

Oral Glucosamine Ameliorates Aggravated Neurological Phenotype in Mucopolysaccharidosis III Type C Mouse Model Expressing Misfolded HGSNAT Variant

A. Pshezhetsky, Y. Yamanaka, D. Priestman, 2021, bioRxiv.

Brain Pathology in Mucopolysaccharidoses (MPS) Patients with Neurological Forms

A. Pshezhetsky, D. Priestman, F. Platt, 2020, Journal of clinical medicine.

Early defects in mucopolysaccharidosis type IIIC disrupt excitatory synaptic transmission

J. Lacaille, A. Pshezhetsky, P. Thibault, 2021, JCI insight.

Early defects in lysosomal storage diseases disrupt excitatory synaptic transmission

J. Lacaille, A. Pshezhetsky, P. Thibault, 2020, bioRxiv.

Histological characterization of retinal degeneration in mucopolysaccharidosis type IIIC.

A. Pshezhetsky, V. Bonilha, Sujata Rao, 2023, Experimental eye research.

Sanfilippo syndrome type C: mutation spectrum in the heparan sulfate acetyl‐CoA: α‐glucosaminide N‐acetyltransferase (HGSNAT) gene

A. Pshezhetsky, S. Kmoch, R. Laframboise, 2009, Human mutation.

Clinical and genetic spectrum of Sanfilippo type C (MPS IIIC) disease in The Netherlands.

A. Pshezhetsky, R. Wevers, J. M. van de Kamp, 2008, Molecular genetics and metabolism.

Localisation of a gene for mucopolysaccharidosis IIIC to the pericentromeric region of chromosome 8

T. Hudson, A. Verner, A. Pshezhetsky, 2004, Journal of Medical Genetics.

Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice

A. Pshezhetsky, N. Heveker, J. Medin, 2018, Molecular metabolism.

Loss of Cellular Sialidases Does Not Affect the Sialylation Status of the Prion Protein but Increases the Amounts of Its Proteolytic Fragment C1

A. Pshezhetsky, N. Makarava, I. Baskakov, 2015, PloS one.

Cloning of the cDNA and gene encoding mouse lysosomal sialidase and correction of sialidase deficiency in human sialidosis and mouse SM/J fibroblasts.

A. Pshezhetsky, J. Trasler, R. Gravel, 1998, Human molecular genetics.

Synthesis of 1-BODIPY-labeled 2-amino-2-deoxy-d-glucose, substrate for acetyl-CoA:glucosaminide N-acetyltransferase

A. Pshezhetsky, N. Bovin, A. Tuzikov, 2015 .

Serine carboxypeptidases in regulation of vasoconstriction and elastogenesis.

A. Pshezhetsky, A. Hinek, 2009, Trends in cardiovascular medicine.

Mice Doubly-Deficient in Lysosomal Hexosaminidase A and Neuraminidase 4 Show Epileptic Crises and Rapid Neuronal Loss

A. Pshezhetsky, E. Hamel, L. Carmant, 2010, PLoS genetics.

Learning disability in rats induced by the immunosuppression of cathepsin A in blood plasma

A. Pshezhetsky, M. Potier, I. Ashmarin, 1997 .

Structural Basis for Substrate Specificity of Mammalian Neuraminidases

A. Pshezhetsky, E. Korchagina, N. Bovin, 2014, PloS one.

Neu1 desialylation of sialyl alpha-2,3-linked beta-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling.

A. Pshezhetsky, M. Szewczuk, R. Beyaert, 2010, Cellular signalling.

Dependence of pathogen molecule-induced Toll-like receptor activation and cell function on Neu1 sialidase

A. Pshezhetsky, K. Gee, M. Szewczuk, 2009, Glycoconjugate Journal.

Development of a Novel Noncompetitive Antagonist of IL-1 Receptor1

A. Pshezhetsky, N. Heveker, M. Leduc, 2008, The Journal of Immunology.

Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides

A. Pshezhetsky, J. Velasco-Martín, K. Yamaguchi, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Influence of the immunization against heterologous alcohol dehydrogenase on liver alcohol dehydrogenase isozymes and alcohol abuse of rats.

A. Pshezhetsky, I. Ashmarin, R. Danilova, 1993, European journal of biochemistry.

ENZYMATIC CLEAVAGE N-GLYCOLYLNEURAMINIC ACID TO 8-LINKED − 2 α OF-Glycolyl Groups : RESISTANCE N with Metabolism of Vertebrate Amino Sugars Glycobiology and Extracellular Matrices :

Matthew B. Tessier, A. Pshezhetsky, A. Varki, 2012 .

Endothelial stress induces the release of vitamin D-binding protein, a novel growth factor.

A. Pshezhetsky, G. Soulez, A. Désormeaux, 2005, Biochemical and biophysical research communications.

Purification, cDNA Cloning, and Expression of a New Human Blood Plasma Glutamate Carboxypeptidase Homologous to N-Acetyl-aspartyl-α-glutamate Carboxypeptidase/Prostate-specific Membrane Antigen*

A. Pshezhetsky, M. El‐Alfy, C. Morales, 1999, The Journal of Biological Chemistry.

Intracellular Distribution of Lysosomal Sialidase Is Controlled by the Internalization Signal in Its Cytoplasmic Tail*

K. Lukong, A. Pshezhetsky, W. Gahl, 2001, The Journal of Biological Chemistry.

Human lysosomal beta-galactosidase-cathepsin A complex: definition of the beta-galactosidase-binding interface on cathepsin A.

A. Pshezhetsky, M. Elsliger, M A Elsliger, 1995, Biochemistry.