J. Edwards

发表

The first potent and selective non-imidazole human histamine H4 receptor antagonists.

J. A. Jablonowski, Cheryl A. Grice, W. Chai, 2003, Journal of medicinal chemistry.

A Prospective Virtual Screening Study: Enriching Hit Rates and Designing Focus Libraries To Find Inhibitors of PI3Kδ and PI3Kγ.

J. Edwards, K. Damm-Ganamet, S. Bembenek, 2016, Journal of medicinal chemistry.

Discovery of Highly Potent and Selective IRAK1 Degraders to Probe Scaffolding Functions of IRAK1 in ABC DLBCL.

Jennifer D. Venable, J. Edwards, U. Philippar, 2021, Journal of medicinal chemistry.

Identification of a Potent and Selective Noncovalent Cathepsin S Inhibitor

Lars Karlsson, James P. Edwards, S. M. Baker, 2004, Journal of Pharmacology and Experimental Therapeutics.

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors. Part 2: Modification of P3, P4, and P5 regions.

John J. M. Wiener, Cheryl A. Grice, L. Karlsson, 2010, Bioorganic & medicinal chemistry letters.

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1.

Cheryl A. Grice, P. Desai, R. Thurmond, 2010, Bioorganic & medicinal chemistry letters.

The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors.

Cheryl A. Grice, Jianmei Wei, Wen Jiang, 2006, Bioorganic & medicinal chemistry letters.

Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity.

John J. M. Wiener, Jennifer D. Venable, Jianmei Wei, 2021, ACS medicinal chemistry letters.

Dual binding site inhibitors of B-RAF kinase.

Jianmei Wei, L. Karlsson, J. Edwards, 2008, Bioorganic & medicinal chemistry letters.

Abstract DDT02-04: A novel PRMT5 inhibitor with potent in vitro and in vivo activity in preclinical lung cancer models

Italo Poggesi, Vineet Pande, James P. Edwards, 2017 .

A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker

Jianmei Wei, L. Karlsson, J. Edwards, 2008, Molecular Cancer Therapeutics.

Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation.

J. Edwards, U. Philippar, R. Attar, 2020, Cell chemical biology.

Selective inhibition of peripheral cathepsin S reverses tactile allodynia following peripheral nerve injury in mouse.

John J. M. Wiener, Cheryl A. Grice, R. Thurmond, 2020, European journal of pharmacology.

A Carboxylic Acid Isostere Screen of the DHODH Inhibitor Brequinar.

J. Edwards, E. Jacoby, S. Kuduk, 2020, Bioorganic & medicinal chemistry letters.

Potent, nonsteroidal selective androgen receptor modulators (SARMs) based on 8H-[1,4]oxazino[2,3-f]quinolin-8-ones.

J. Edwards, E. Kallel, D. Karanewsky, 2007, Bioorganic & medicinal chemistry letters.

5-benzylidene-1,2-dihydrochromeno[3,4-f]quinolines as selective progesterone receptor modulators.

J. Edwards, B. Pio, T. K. Jones, 2003, Journal of medicinal chemistry.

Identification and biological evaluation of thiazole-based inverse agonists of RORγt.

Michael Albers, J. Edwards, J. Spurlino, 2018, Bioorganic & medicinal chemistry letters.

4-Alkyl- and 3,4-dialkyl-1,2,3,4-tetrahydro-8-pyridono[5,6-g]quinolines: potent, nonsteroidal androgen receptor agonists.

J. Edwards, L. Hamann, T. K. Jones, 1999, Bioorganic & medicinal chemistry letters.

6-Substituted quinolines as RORγt inverse agonists.

J. Edwards, J. Spurlino, M. Cummings, 2017, Bioorganic & medicinal chemistry letters.

Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt.

Michael Albers, J. Edwards, J. Spurlino, 2020, Bioorganic & medicinal chemistry letters.

Immunological characterization of HM5023507, an orally active PI3Kδ/γ inhibitor

P. Acton, J. Edwards, T. Rao, 2020, Pharmacology research & perspectives.

N-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia.

Colleen E. Keohane, J. Edwards, E. Jacoby, 2022, Journal of medicinal chemistry.

Discovery, Optimization, and Evaluation of Potent and Highly Selective PI3Kγ-PI3Kδ Dual Inhibitors.

J. Edwards, T. Rao, S. Bembenek, 2019, Journal of medicinal chemistry.

Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach.

Michael Albers, J. Edwards, M. Cummings, 2020, Bioorganic & medicinal chemistry letters.

Nonsteroidal androgen receptor agonists based on 4-(trifluoromethyl)-2H-pyrano[3,2-g]quinolin-2-one.

J. Edwards, L. Hamann, M. Goldman, 1999, Bioorganic & medicinal chemistry letters.

New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g] quinolinone.

J. Edwards, T. K. Jones, K. Marschke, 1998, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of a novel series of nonsteroidal, peripherally selective androgen receptor antagonists derived from 1,2-dihydropyridono[5,6-g]quinolines.

J. Edwards, L. Hamann, T. K. Jones, 1998, Journal of medicinal chemistry.

Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt.

J. Edwards, J. Spurlino, M. Cummings, 2017, Bioorganic & medicinal chemistry letters.

Organocerium additions to proline-derived hydrazones: synthesis of enantiomerically enriched amines

J. Edwards, S. Denmark, D. W. Piotrowski, 2010 .

Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.

Cheryl A. Grice, Jianmei Wei, L. Karlsson, 2008, Journal of medicinal chemistry.

Novel series of potent, nonsteroidal, selective androgen receptor modulators based on 7H-[1,4]oxazino[3,2-g]quinolin-7-ones.

Dale E Mais, James P Edwards, J. Edwards, 2007, Journal of medicinal chemistry.

Minisci-Photoredox-Mediated α-Heteroarylation of N-Protected Secondary Amines: Remarkable Selectivity of Azetidines.

J. Edwards, H. Beucher, L. Meerpoel, 2018, Organic letters.

Benzannulation of stannylquinones. A new regiocontrolled construction of substituted naphtho- and anthraquinones

J. Edwards, D. Krysan, L. S. Liebeskind, 1993 .

Organocerium Additions to Hydrazones: Effects of Reagent Stoichiometry on Efficiency and Selectivity

J. Edwards, S. Denmark, O. J. Nicaise, 1993 .

Preparation, resolution, and biological evaluation of 5-aryl-1, 2-dihydro-5H-chromeno[3,4-f]quinolines: potent, orally active, nonsteroidal progesterone receptor agonists.

J. Edwards, M. Gottardis, C. Pathirana, 1998, Journal of medicinal chemistry.

Solution and solid-state structure of the "Wittig-Furukawa" cyclopropanation reagent

Scott R. Wilson, J. Edwards, S. Denmark, 1991 .

Tricyclic aminopyrimidine histamine H4 receptor antagonists.

Cheryl A. Grice, R. Thurmond, J. Edwards, 2011, Bioorganic & medicinal chemistry letters.

5-Alkyl 1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal progesterone receptor modulators.

J. Edwards, M. Gottardis, T. K. Jones, 1998, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators.

J. Edwards, B. Pio, T. K. Jones, 2003, Bioorganic & medicinal chemistry letters.

Lithium/ammonia cleavage of the nitrogen-nitrogen bond in N-(methoxycarbonyl)- and N-acetylhydrazines

J. Edwards, S. Denmark, O. J. Nicaise, 1990 .

Modified Proline Auxiliaries for Selective Addition of Organocerium Reagents to Hydrazones

J. Edwards, S. Denmark, T. Weber, 1989 .

A comparison of (chloromethyl)- and (iodomethyl)zinc cyclopropanation reagents

J. Edwards, S. Denmark, 1991 .

Preparation of Chiral Bisoxazolines: Observations on the Effect of Substituents

J. Edwards, S. Denmark, N. Nakajima, 1995 .

Effects of isosteric pyridone replacements in androgen receptor antagonists based on 1,2-dihydro- and 1,2,3,4-tetrahydro-2,2-dimethyl-6-trifluoromethyl-8-pyridono[5,6-g]quin olines.

J. Edwards, L. Hamann, T. K. Jones, 2000, Bioorganic & medicinal chemistry letters.

Lewis-acid catalyzed reaction of 2-isopropenylaniline with ketones: Improved synthesis of 2,2,4-trisubstituted 1,2-dihydroquinolines

J. Edwards, T. K. Jones, J. D. Ringgenberg, 1998 .

Discovery and preliminary SAR studies of a novel, nonsteroidal progesterone receptor antagonist pharmacophore.

J. Edwards, M. Goldman, T. K. Jones, 1998, Journal of medicinal chemistry.

Benzannulation of Stannylquinones. A New Regiocontrolled Construction of Substituted Naphtho- and Anthraquinones.

J. Edwards, D. Krysan, L. S. Liebeskind, 1994 .

Pyrazole-based arylalkyne cathepsin S inhibitors. Part II: optimization of cellular potency.

James P Edwards, Lars Karlsson, R. Thurmond, 2009, Bioorganic & medicinal chemistry letters.

Cyclopropanation with Diazomethane and Bis(oxazoline)palladium(II) Complexes.

J. Edwards, S. Denmark, R. Stavenger, 1997, The Journal of organic chemistry.

Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.

J. A. Jablonowski, Cheryl A. Grice, W. Chai, 2005, Journal of medicinal chemistry.

Acyclic Stereoselection in the Ortho Ester Claisen Rearrangement.

J. Edwards, M. Dibley, C. T. Maxey, 1997, The Journal of organic chemistry.

Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors.

Jianmei Wei, Wen Jiang, R. Thurmond, 2005, Bioorganic & medicinal chemistry letters.

4-Alkyl- and 3,4-dialkyl-1,2,3,4-tetrahydro-8-pyridono[5,6-g]quinolines: potent, nonsteroidal androgen receptor agonists.

J. Edwards, L. Hamann, T. K. Jones, 1999, Bioorganic & medicinal chemistry letters.

Selective phenol alkylation for an improved synthesis of 2-arylbenzimidazole H4 receptor ligands

J. Edwards, M. SavallBrad, Jill R. Fontimayor, 2009 .

Synthesis of 3-methoxy-quinoxalin-2-ones from methyl trimethoxyacetate and phenylenediamines

Jennifer D. Venable, J. Edwards, M. Peterson, 2010 .

A general, regioselective synthesis of substituted benzocyclobutenedione monoacetals

J. Edwards, D. Krysan, L. S. Liebeskind, 1993 .

Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists.

R. Thurmond, J. Edwards, M. Hack, 2014, Journal of medicinal chemistry.

5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines as potent, orally active, nonsteroidal progesterone receptor agonists: the effect of D-ring substituents.

J. Edwards, M. Gottardis, T. K. Jones, 1998, Journal of Medicinal Chemistry.

Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore.

J. Edwards, B. Pio, T. K. Jones, 2003, Bioorganic & medicinal chemistry letters.

Nonsteroidal progesterone receptor antagonists based on a conformationally-restricted subseries of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines.

J. Edwards, L. Hamann, M. Goldman, 1998, Bioorganic & medicinal chemistry letters.

Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation

R. Thurmond, L. Karlsson, J. Edwards, 2004, British journal of pharmacology.

HISTAMINE RELEASE IN POST-CHALLENGE CŒLIAC DISEASE

J. Edwards, D. Challacombe, J. Baylis, 1980, The Lancet.

A Potent and Selective Histamine H4 Receptor Antagonist with Anti-Inflammatory Properties

Lars Karlsson, James P. Edwards, P. Desai, 2004, Journal of Pharmacology and Experimental Therapeutics.

Small-Molecule Targets in Immuno-Oncology.

J. Edwards, D. Dhanak, P. Tummino, 2017, Cell chemical biology.

Clinical Development of Histamine H4 Receptor Antagonists.

Jennifer D. Venable, R. Thurmond, J. Edwards, 2017, Handbook of experimental pharmacology.

Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements.

James P Edwards, Scott D Bembenek, Lars Karlsson, 2009, Bioorganic & medicinal chemistry letters.

Pyrazole-based cathepsin S inhibitors with improved cellular potency.

Wen Jiang, James P Edwards, Lars Karlsson, 2007, Bioorganic & medicinal chemistry letters.

Pyrazole-based arylalkyne cathepsin S inhibitors. Part III: modification of P4 region.

John J. M. Wiener, Lars Karlsson, James P. Edwards, 2013, Bioorganic & medicinal chemistry letters.

Cathepsin S inhibitors as novel immunomodulators.

R. Thurmond, L. Karlsson, J. Edwards, 2005, Current opinion in investigational drugs.

Accelerating Lead Identification by High Throughput Virtual Screening: Prospective Case Studies from the Pharmaceutical Industry

John J. M. Wiener, Nidhi Arora, James P Edwards, 2019, J. Chem. Inf. Model..

Anti-Inflammatory Activity of a Potent, Selective Leukotriene A4 Hydrolase Inhibitor in Comparison with the 5-Lipoxygenase Inhibitor Zileuton

James P Edwards, Lars Karlsson, Navin L Rao, 2007, Journal of Pharmacology and Experimental Therapeutics.

Abstract 5690: Discovery of JNJ-67856633: A novel, first-in-class MALT1 protease inhibitor for the treatment of B cell lymphomas

J. Edwards, G. Vanhoof, U. Philippar, 2020, Cancer Chemistry.

DISCOVERY OF A NOVEL, POTENTIAL FIRST‐IN‐CLASS MALT1 PROTEASE INHIBITOR FOR THE TREATMENT OF B CELL LYMPHOMAS

J. Edwards, G. Vanhoof, U. Philippar, 2019, Hematological Oncology.

Proteases as Drug Targets

R. Thurmond, J. Edwards, 2006 .

Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease.

J. Edwards, Tianbao Lu, U. Philippar, 2019, Bioorganic & medicinal chemistry letters.

Nonpeptidic, noncovalent inhibitors of the cysteine protease cathepsin S.

Mary Pat Beavers, James P Edwards, Lars Karlsson, 2004, Journal of medicinal chemistry.

Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease.

W. Chai, Jennifer D. Venable, J. Edwards, 2020, Journal of medicinal chemistry.

Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.

John J. M. Wiener, Jennifer D. Venable, Jianmei Wei, 2022, Journal of medicinal chemistry.

Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors.

James P Edwards, Scott D Bembenek, Lars Karlsson, 2010, Bioorganic & medicinal chemistry letters.

Chiral Amino Alcohol Modified Halomethylzinc Reagents

J. Edwards, S. Denmark, 1992 .

Identification of small-molecule protein–protein interaction inhibitors for NKG2D

Jennifer D. Venable, J. Edwards, A. Thompson, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation

R. Thurmond, L. Karlsson, J. Edwards, 2004 .

Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands.

James P Edwards, Lars Karlsson, J Guy Breitenbucher, 2006, Bioorganic & medicinal chemistry letters.

Clinical Development of Histamine H4 Receptor Antagonists.

Jennifer D. Venable, R. Thurmond, J. Edwards, 2017, Handbook of experimental pharmacology.