U. Günther

发表

PhenoMeNal: processing and analysis of metabolomics data in the cloud

Alejandra N. González-Beltrán, Marco Enrico Piras, Jake T. M. Pearce, 2018, bioRxiv.

Systems biologists seek fuller integration of systems biology approaches in new cancer research programs.

Olaf Wolkenhauer, Nils Blüthgen, Charles Auffray, 2010, Cancer research.

SALMON: solvent accessibility, ligand binding, and mapping of ligand orientation by NMR spectroscopy.

Christian Ludwig, Udo Oppermann, U. Günther, 2008, Journal of medicinal chemistry.

Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn’s disease and healthy individuals

U. Günther, C. Ludwig, O. Nielsen, 2014, Metabolomics.

Metabolomics Biomarkers for Breast Cancer

U. Günther, 2015, Pathobiology.

Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells

U. Günther, M. Reed, J. Cazier, 2021, bioRxiv.

COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access

Matej Oresic, Christoph Steinbeck, Dirk Walther, 2015, Metabolomics.

Birmingham Metabolite Library: a publicly accessible database of 1-D 1H and 2-D 1H J-resolved NMR spectra of authentic metabolite standards (BML-NMR)

Theodoros N. Arvanitis, John M. Easton, Shan He, 2011, Metabolomics.

Metabolic Fluxes in Cancer Metabolism

U. Günther, F. Khanim, C. Bunce, 2015 .

Quantitative Isotopomer Rates in Real‐Time Metabolism of Cells Determined by NMR Methods

U. Günther, M. Reed, E. Kupče, 2019, ChemBioChem.

MALDI profiles of proteins and lipids for the rapid characterisation of upper GI-tract cancers.

U. Günther, C. Ludwig, D. Ward, 2013, Journal of proteomics.

Nuclear Magnetic Resonance‐based Drug Discovery

U. Günther, H. Rüterjans, Christina Fischer, 2005 .

Validation of a urine metabolome fingerprint in dog for phenotypic classification

U. Günther, C. Ludwig, M. Viant, 2007, Metabolomics.

Solution structures of the DP IV (CD26) inhibitor Val‐boroPro determined by NMR spectroscopy

U. Günther, R. Snow, R. Barton, 1995 .

Solution structures of active and inactive forms of the DP IV (CD26) inhibitor Pro-boroPro determined by NMR spectroscopy.

U. Günther, R. Snow, R. Barton, 1994, Biochemistry.

NMR analysis of interactions of a phosphatidylinositol 3'-kinase SH2 domain with phosphotyrosine peptides reveals interdependence of major binding sites.

U. Günther, B. Schaffhausen, Y. Liu, 1996, Biochemistry.

Evaluation of Solvent Accessibility Epitopes for Different Dehydrogenase Inhibitors

U. Günther, C. Ludwig, C. Bunce, 2008, ChemMedChem.

Fast targeted multidimensional NMR metabolomics of colorectal cancer

M R Viant, U. Günther, C. Ludwig, 2009, Magnetic resonance in chemistry : MRC.

Optimizing the polarization matrix for ex situ dynamic nuclear polarization.

U. Günther, C. Ludwig, M. Saunders, 2010, Journal of the American Chemical Society.

NMR structure of the N-SH2 of the p85 subunit of phosphoinositide 3-kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site.

U. Günther, T. Weber, B. Schaffhausen, 2000, Biochemistry.

Monitoring of photopolymerization processes by NMR imaging

U. Günther, K. Albert, M. Grossa, 1992 .

Metabolomic Evidence for a Field Effect in Histologically Normal and Metaplastic Tissues in Patients with Esophageal Adenocarcinoma1

U. Günther, C. Ludwig, M. Reed, 2017, Neoplasia.

Early Stage Diagnosis of Oral Cancer Using

U. Günther, S. Tiziani, V. Lopes, 2009 .

Early Stage Diagnosis of Oral Cancer Using 1 H NMR – Based Metabolomics 1,2

U. Günther, S. Tiziani, V. Lopes, 2009 .

A lyophilized red grape pomace containing proanthocyanidin-rich dietary fiber induces genetic and metabolic alterations in colon mucosa of female C57BL/6J mice.

M. Cascante, U. Günther, M. Reed, 2011, The Journal of nutrition.

University of Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn’s disease and healthy individuals

U. Günther, C. Ludwig, O. Nielsen, 2015 .

Plasma metabolic profile in COPD patients: effects of exercise and endurance training

M. Cascante, U. Günther, M. Reed, 2012, Metabolomics.

Improved Stability and Spectral Quality in Ex Situ Dissolution DNP Using an Improved Transfer Device

U. Günther, C. Ludwig, M. Pons, 2015 .

Real‐Time NMR Spectroscopy for Studying Metabolism

H. Schwalbe, U. Günther, C. Richter, 2019, Angewandte Chemie.

Detecting acetylated aminoacids in blood serum using hyperpolarized 13C-1Η-2D-NMR.

U. Günther, C. Ludwig, I. Marin-Montesinos, 2019, Journal of magnetic resonance.

Site-specific investigation of the steady-state kinetics and dynamics of the multistep binding of bile acid molecules to a lipid carrier protein.

U. Günther, C. Ludwig, M. Assfalg, 2010, Chemistry.

Sensitivity Optimization in Continuous-Flow FTNMR

U. Günther, J. Sudmeier, W. Bachovchin, 1996 .

COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access

R. Goodacre, M. Nikolski, Susanna-Assunta Sansone, 2015, Metabolomics.

Dynamic nuclear hyperpolarization in liquids.

U. Günther, Ulrich L Günther, 2013, Topics in current chemistry.

Early stage diagnosis of oral cancer using 1H NMR-based metabolomics.

Stefano Tiziani, U. Günther, Ulrich L Günther, 2009, Neoplasia.

Changes in human hepatic metabolism in steatosis and cirrhosis

U. Günther, M. Reed, D. Adams, 2017, World journal of gastroenterology.

Nuclear magnetic resonance detects phosphoinositide 3-kinase/Akt-independent traits common to pluripotent murine embryonic stem cells and their malignant counterparts.

U. Günther, Z. Gulzar, E. Lalani, 2009, Neoplasia.

Proliferation and Survival of T-cell Acute Lymphoblastic Leukaemia Depends on mTOR-regulated Glutamine Uptake and EAAT1-dependent Conversion of Glutamine to Aspartate and Nucleotides

U. Günther, C. Ludwig, M. Reed, 2020 .

Survival and Proliferation of T-cell Acute Lymphoblastic Leukaemia Depends on mTOR-regulated Glutamine Uptake and EAAT1 Activity

U. Günther, C. Ludwig, M. Reed, 2020 .

COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access

Matej Oresic, Christoph Steinbeck, Dirk Walther, 2015, Metabolomics.

Maslinic Acid-Enriched Diet Decreases Intestinal Tumorigenesis in ApcMin/+ Mice through Transcriptomic and Metabolomic Reprogramming

Fernando J. Reyes-Zurita, M. Cascante, U. Günther, 2013, PloS one.

Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis

U. Günther, G. Hirschfield, D. Erion, 2020, JHEP reports : innovation in hepatology.

TKTL1 Knockdown Impairs Hypoxia-Induced Glucose-6-phosphate Dehydrogenase and Glyceraldehyde-3-phosphate Dehydrogenase Overexpression

M. Cascante, U. Günther, I. Baptista, 2022, International journal of molecular sciences.

Hypoxia Triggers Major Metabolic Changes in AML Cells without Altering Indomethacin-Induced TCA Cycle Deregulation

U. Günther, M. Viant, F. Khanim, 2010, ACS chemical biology.

Metabolomic Profiling of Drug Responses in Acute Myeloid Leukaemia Cell Lines

Mark R. Viant, Ulrich L. Günther, Stefano Tiziani, 2009, PloS one.

Metabolic plasticity in CLL: adaptation to the hypoxic niche

U. Günther, C. Ludwig, F. Khanim, 2015, Leukemia.

Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR.

U. Günther, C. Ludwig, M. Wheatley, 2008, Biochemistry.

Proposed reporting requirements for the description of NMR-based metabolomics experiments

Nigel W. Hardy, Nigel Hardy, Mark R. Viant, 2007, Metabolomics.

Application of ex situ dynamic nuclear polarization in studying small molecules.

Christian Ludwig, Zoe Pikramenou, Abdul-Hamid Emwas, 2010, Physical chemistry chemical physics : PCCP.

Determinants for Optimal Enhancement in Ex Situ DNP Experiments

Christian Ludwig, Ulrich L. Günther, Abdul-Hamid Emwas, 2008 .

Optimized metabolite extraction from blood serum for 1H nuclear magnetic resonance spectroscopy.

Mark R Viant, Christian Ludwig, Abdul-Hamid Emwas, 2008, Analytical biochemistry.

NMRKIN: Simulating line shapes from two-dimensional spectra of proteins upon ligand binding

U. Günther, B. Schaffhausen, 2002, Journal of biomolecular NMR.

Modulation of structure and dynamics by disulfide bond formation in unfolded states.

Robert Silvers, H. Schwalbe, M. Blackledge, 2012, Journal of the American Chemical Society.

Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway

Alan J. Robinson, Stefan Neubauer, Mark R. Viant, 2012, Cell metabolism.

Metabonomics uncovers a reversible proatherogenic lipid profile during infliximab therapy of inflammatory bowel disease

U. Günther, M. Reed, O. Nielsen, 2017, BMC Medicine.

Metabolic and Lipidomic Markers Differentiate COVID-19 From Non-Hospitalized and Other Intensive Care Patients

U. Günther, C. Sina, Alvaro Mallagaray, 2021, Frontiers in Molecular Biosciences.

nmrML: A Community Supported Open Data Standard for the Description, Storage, and Exchange of NMR Data.

Christoph Steinbeck, Daniel Schober, Jie Hao, 2018, Analytical chemistry.

T-ALL Proliferation Relies on Glutamine Uptake and EAAT1-dependent Conversion of Glutamine to Aspartate and Nucleotides

U. Günther, C. Ludwig, M. Reed, 2023, bioRxiv.

Regulation of the Mitochondrion-Fatty Acid Axis for the Metabolic Reprogramming of Chlamydia trachomatis during Treatment with β-Lactam Antimicrobials

K. Köhrer, U. Günther, K. Shima, 2021, mBio.

Regulation of the Mitochondrion-Fatty Acid Axis for the Metabolic Reprogramming of Chlamydia trachomatis during Treatment with Î2-Lactam Antimicrobials

K. Köhrer, U. Günther, K. Shima, 2021 .

The Role of Large-Scale Motions in Catalysis by Dihydrofolate Reductase

U. Günther, S. Whittaker, E. J. Loveridge, 2011, Journal of the American Chemical Society.

Validation of a urine metabolome fingerprint in dog for phenotypic classification

Mark R. Viant, Christian Ludwig, Ulrich L. Günther, 2007, Metabolomics.

Using wavelet de-noised spectra in NMR screening.

Ulrich Günther, U. Günther, T. Langer, 2005, Journal of magnetic resonance.

Plasma metabolic profile in COPD patients: effects of exercise and endurance training

M. Cascante, U. Günther, M. Reed, 2012, Metabolomics.

Improved classification accuracy in 1- and 2-dimensional NMR metabolomics data using the variance stabilising generalised logarithm transformation

Mark R. Viant, Christian Ludwig, Ulrich L. Günther, 2007, BMC Bioinformatics.

HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

U. Günther, J. Martens, E. Vellenga, 2019, Cancer & Metabolism.

Targeting Asparagine and Serine Metabolism in Germinal Centre-Derived B Cells Non-Hodgkin Lymphomas (B-NHL)

U. Günther, F. Khanim, J. Cazier, 2021, Cells.

HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

U. Günther, J. Martens, E. Vellenga, 2019, Cancer & Metabolism.

Metabolomic Analysis of Diapausing and Noni-diapausing Larvae of the European Corn Borer Ostrinia nubilalis (Hbn.) (Lepidoptera: Crambidae).

U. Günther, S. Tiziani, Ž. Popović, 2015, Acta chimica Slovenica.

A strategy to obtain backbone resonance assignments of deuterated proteins in the presence of incomplete amide 2H/1H back-exchange

U. Günther, F. Löhr, H. Rüterjans, 2003, Journal of biomolecular NMR.

MetaboLab - advanced NMR data processing and analysis for metabolomics

Christian Ludwig, Ulrich L. Günther, U. Günther, 2011, BMC Bioinformatics.

HCN, a triple-resonance NMR technique for selective observation of histidine and tryptophan side chains in 13C/15N-labeled proteins.

U. Günther, J. Sudmeier, W. Bachovchin, 1996, Journal of Magnetic Resonance - Series B.

Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells.

Adrian L Harris, Francesca M Buffa, A. Harris, 2012, Cell metabolism.

Proton NMR-Based Metabolite Analyses of Archived Serial Paired Serum and Urine Samples from Myeloma Patients at Different Stages of Disease Activity Identifies Acetylcarnitine as a Novel Marker of Active Disease

G. Morgan, U. Günther, M. Viant, 2013, PloS one.

Nuclear magnetic resonance structure of the P395S mutant of the N-SH2 domain of the p85 subunit of PI3 kinase: an SH2 domain with altered specificity.

U. Günther, B. Schaffhausen, B. Weyrauch, 2003, Biochemistry.

A framework for tracer-based metabolism in mammalian cells by NMR

U. Günther, M. Reed, F. Khanim, 2019, Scientific Reports.

Assignment of the orphan nuclear receptor Nurr1 by NMR

U. Günther, C. Ludwig, P. Michiels, 2010, Biomolecular NMR assignments.

Tracer-Based Metabolic NMR-Based Flux Analysis in a Leukaemia Cell Line.

U. Günther, C. Ludwig, M. Reed, 2016, ChemPlusChem.

The Metabolic Profile of Stable Ischemic Heart Disease by Serum 1H NMR

U. Günther, C. Ludwig, M. Viigimaa, 2018, Applied Magnetic Resonance.

Birmingham Metabolite Library: a publicly accessible database of 1-D 1H and 2-D 1H J-resolved NMR spectra of authentic metabolite standards (BML-NMR)

Theodoros N. Arvanitis, U. Günther, C. Ludwig, 2012, Metabolomics.

Ligand-based NMR spectra demonstrate an additional phytoestrogen binding site for 17β-hydroxysteroid dehydrogenase type 1

U. Günther, C. Ludwig, J. Adamski, 2009, The Journal of Steroid Biochemistry and Molecular Biology.

De novo design of a stable N-terminal helical foldamer.

Charles H. Cureton, U. Günther, C. Ludwig, 2005, Organic & biomolecular chemistry.

Malonate as a ROS product is associated with pyruvate carboxylase activity in acute myeloid leukaemia cells

U. Günther, C. Ludwig, M. Reed, 2016, Cancer & metabolism.

Tracer‐Based Metabolic NMR‐Based Flux Analysis in a Leukaemia Cell Line

U. Günther, C. Ludwig, M. Reed, 2016, ChemPlusChem.

Quantum rotor induced hyperpolarization

Christian Ludwig, U. Günther, C. Ludwig, 2010, Proceedings of the National Academy of Sciences.

Food Fingerprinting: LC-ESI-IM-QTOF-Based Identification of Blumeatin as a New Marker Metabolite for the Detection of Origanum majorana Admixtures to O. onites/vulgare

U. Günther, M. Creydt, Markus Fischer, 2023, Metabolites.

Automated Protein NMR Structure Determination Using Wavelet De-noised NOESY Spectra

Ulrich Günther, U. Günther, Felician Dancea, 2005, Journal of biomolecular NMR.

Hypoxia-Like Signatures Induced by BCR-ABL Potentially Alter the Glutamine Uptake for Maintaining Oxidative Phosphorylation

U. Günther, E. Vellenga, J. Schuringa, 2016, PloS one.

Probing Src homology 2 domain ligand interactions by differential line broadening.

U. Günther, B. Schaffhausen, T. Mittag, 2002, Biochemistry.

Backbone assignment of the N-terminal polyomavirus large T antigen

U. Günther, C. Ludwig, B. Schaffhausen, 2009, Biomolecular NMR assignments.

Chapter 2:1D and 2D NMR Spectroscopy: From Metabolic Fingerprinting to Profiling

U. Günther, C. Ludwig, M. Viant, 2007 .

Real‐Time NMR Spectroscopy for Studying Metabolism

H. Schwalbe, U. Günther, C. Richter, 2019, Angewandte Chemie.

University of Birmingham PhenoMeNal

Alejandra N. González-Beltrán, Marco Enrico Piras, Ralf J. M. Weber, 2019 .

Retinol modulates site-specific mobility of apo-cellular retinol-binding protein to promote ligand binding.

U. Günther, B. Schaffhausen, L. Franzoni, 2006, Journal of the American Chemical Society.

Combined Analysis of NMR and MS Spectra (CANMS).

M. Cascante, U. Günther, C. Ludwig, 2017, Angewandte Chemie.

Selective AKR1C3 inhibitors do not recapitulate the anti-leukaemic activities of the pan-AKR1C inhibitor medroxyprogesterone acetate

U. Günther, F. Khanim, R. Hayden, 2014, British Journal of Cancer.

Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells.

A. Harris, U. Günther, D. Ferguson, 2012, Cell metabolism.

Systems biologists seek fuller integration of systems biology approaches in new cancer research programs.

D. Fell, C. Auffray, J. Tyson, 2010, Cancer research.

Erratum to: COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access

R. Goodacre, M. Nikolski, Susanna-Assunta Sansone, 2015, Metabolomics.

Qualitative and quantitative food authentication of oregano using NGS and NMR with chemometrics

U. Günther, M. Creydt, Friedemann Flügge, 2022, Food Control.

NMRLAB-Advanced NMR data processing in matlab

Ludwig, Gunther, Ruterjans, 2000, Journal of magnetic resonance.

WAVEWAT-improved solvent suppression in NMR spectra employing wavelet transforms.

Heinz Rüterjans, Christian Ludwig, U. Günther, 2002, Journal of magnetic resonance.

nmrML: A Community Supported Open Data Standard for the Description, Storage, and Exchange of NMR Data.

Joseph A. Cruz, D. Wishart, T. Ebbels, 2018, Analytical chemistry.

COordination of Standards in MetabOlomicS ( COSMOS ) : facilitating integrated metabolomics

M. Nikolski, Susanna-Assunta Sansone, T. Ebbels, 2018 .

Tracing kinetic intermediates during ligand binding.

U. Günther, B. Schaffhausen, Tanja Mittag, 2004, Journal of the American Chemical Society.

Direct observation of protein-ligand interaction kinetics.

U. Günther, B. Schaffhausen, Tanja Mittag, 2003, Biochemistry.

University of Birmingham MetaboLab - advanced NMR data processing and analysis for metabolomics

U. Günther, Christian Ludwig, Ulrich Gunther, 2022 .

Metabolomics in Cell Biology.

M. Cascante, U. Günther, Zuhal Eraslan, 2022, Handbook of experimental pharmacology.