R. Clark

Christopher M. Horvat, S. Venkataraman, R. Clark, 2019, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Assessment of Antioxidant Reserves and Oxidative Stress in Cerebrospinal Fluid after Severe Traumatic Brain Injury in Infants and Children

P. Kochanek, R. Clark, H. Bayır, 2002, Pediatric Research.

No long-term benefit from hypothermia after severe traumatic brain injury with secondary insult in rats

S. Wisniewski, P. Kochanek, D. Marion, 2000, Critical care medicine.

Traumatic brain injury in mice deficient in poly-ADP(ribose) polymerase: a preliminary report.

P. Kochanek, D. Marion, R. Clark, 2000, Acta neurochirurgica. Supplement.

Reduction of Cognitive and Motor Deficits after Traumatic Brain Injury in Mice Deficient in Poly(ADP-Ribose) Polymerase

P. Kochanek, D. Marion, R. Clark, 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

No long-term benefit from hypothermia after severe traumatic brain injury with secondary insult in rats.

S. Wisniewski, P. Kochanek, D. Marion, 1999 .

Early neuropathologic effects of mild or moderate hypoxemia after controlled cortical impact injury in rats.

P. Kochanek, D. Marion, S. DeKosky, 1997, Journal of neurotrauma.

boc-Aspartyl(OMe)-Fluoromethylketone Attenuates Mitochondrial Release of Cytochrome c and Delays Brain Tissue Loss after Traumatic Brain Injury in Rats

Simon C Watkins, P. Kochanek, J. Melick, 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Proteolysis consistent with activation of caspase-7 after severe traumatic brain injury in humans.

Simon C Watkins, P. Kochanek, D. Marion, 2006, Journal of neurotrauma.

Caspase‐8 expression and proteolysis in human brain after severe head injury

Simon C Watkins, P. Kochanek, D. Marion, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest

P. Kochanek, R. Clark, R. Jha, 2018, Pediatric Research.

Exploratory study of serum ubiquitin carboxyl-terminal esterase L1 and glial fibrillary acidic protein for outcome prognostication after pediatric cardiac arrest.

C. Callaway, D. Angus, P. Kochanek, 2016, Resuscitation.

Induction of the stress response after inflicted and non-inflicted traumatic brain injury in infants and children.

P. Kochanek, R. Clark, P. Adelson, 2004, Journal of neurotrauma.

Quinolinic Acid is Increased in CSF and Associated with Mortality after Traumatic Brain Injury in Humans

E. Sinz, S. Wisniewski, P. Kochanek, 1998, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Effectiveness of Pharmacological Therapies for Intracranial Hypertension in Children With Severe Traumatic Brain Injury—Results From an Automated Data Collection System Time-Synched to Drug Administration

E. Tyler-Kabara, S. Wisniewski, P. Kochanek, 2016, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Mitochondrial injury after mechanical stretch of cortical neurons in vitro: biomarkers of apoptosis and selective peroxidation of anionic phospholipids.

P. Kochanek, R. Clark, H. Bayır, 2012, Journal of neurotrauma.

Resuscitation of traumatic brain injury and hemorrhagic shock with polynitroxylated albumin, hextend, hypertonic saline, and lactated Ringer's: Effects on acute hemodynamics, survival, and neuronal death in mice.

P. Kochanek, R. Clark, H. Bayır, 2009, Journal of neurotrauma.

Cerebral resuscitation after traumatic brain injury and cardiopulmonary arrest in infants and children in the new millennium.

P. Kochanek, R. Clark, C. Dixon, 2001, Pediatric clinics of North America.

Chapter 11 Autophagy in Neurite Injury and Neurodegeneration

R. Clark, C. Chu, R. Hickey, 2009 .

Autophagy in neurite injury and neurodegeneration: in vitro and in vivo models.

R. Clark, C. Chu, R. Hickey, 2009, Methods in enzymology.

Brain-Specific Serum Biomarkers Predict Neurological Morbidity in Diagnostically Diverse Pediatric Intensive Care Unit Patients

P. Kochanek, R. Clark, M. Bell, 2018, Neurocritical Care.

Local administration of the poly(ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice.

R. Clark, C. Dixon, L. Jenkins, 2007, Journal of neurotrauma.

Starving Neurons Show Sex Difference in Autophagy*

Simon C Watkins, G. Gibson, P. Kochanek, 2009, Journal of Biological Chemistry.

POSTTRAUMATIC HYPOTHERMIA DECREASES MORTALITY AFTER SEVERE CONTROLLED CORTICAL IMPACT IN RATS.

P. Kochanek, J. Schiding, D. Marion, 1995 .

Cerebrospinal Fluid Mitochondrial DNA: A Novel DAMP in Pediatric Traumatic Brain Injury

P. Kochanek, R. Clark, M. Bell, 2014, Shock.

Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children

Bedda L. Rosario, Christopher M. Horvat, S. Wisniewski, 2017, PloS one.

Probenecid, an organic anion transporter 1 and 3 inhibitor, increases plasma and brain exposure of N-acetylcysteine

P. Kochanek, R. Clark, H. Bayır, 2017, Xenobiotica; the fate of foreign compounds in biological systems.

24 vs. 72 hours of hypothermia for pediatric cardiac arrest: A pilot, randomized controlled trial.

C. Callaway, D. Angus, P. Kochanek, 2018, Resuscitation.

Therapeutic hypothermia: applications in pediatric cardiac arrest.

P. Kochanek, R. Clark, H. Bayır, 2009, Journal of neurotrauma.

The Potential for Bio-Mediators and Biomarkers in Pediatric Traumatic Brain Injury and Neurocritical Care

P. Kochanek, R. Clark, H. Bayır, 2013, Front. Neurol..

Global lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of acute brain injury

P. Kochanek, R. Clark, D. Okonkwo, 2012, Nature Neuroscience.

Fever control and application of hypothermia using intravenous cold saline

P. Kochanek, R. Clark, M. Bell, 2012, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Autophagy Biomarkers Beclin 1 and p62 are Increased in Cerebrospinal Fluid after Traumatic Brain Injury

P. Kochanek, R. Clark, H. Bayır, 2017, Neurocritical Care.

Traumatic brain injury research highlights in 2015

P. Kochanek, R. Clark, 2016, The Lancet Neurology.

Cerebrospinal fluid levels of high-mobility group box 1 and cytochrome C predict outcome after pediatric traumatic brain injury.

P. Kochanek, R. Clark, H. Bayır, 2012, Journal of Neurotrauma.

72-kDa heat shock protein and mRNA expression after controlled cortical impact injury with hypoxemia in rats.

P. Kochanek, J. Schiding, R. Clark, 1998, Journal of neurotrauma.

Traumatic Brain Injury: Laboratory Studies

P. Kochanek, R. Clark, L. Jenkins, 2005 .

Interstitial adenosine, inosine, and hypoxanthine are increased after experimental traumatic brain injury in the rat.

S. Wisniewski, P. Kochanek, J. Schiding, 1998, Journal of neurotrauma.

Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness

Simon C Watkins, P. Kochanek, R. Clark, 2008, Autophagy.

α-Synuclein Levels Are Elevated in Cerebrospinal Fluid following Traumatic Brain Injury in Infants and Children: The Effect of Therapeutic Hypothermia

S. Wisniewski, P. Kochanek, R. Clark, 2010, Developmental Neuroscience.

Quantification of Poly(ADP-Ribose)-Modified Proteins in Cerebrospinal Fluid from Infants and Children after Traumatic Brain Injury

P. Kochanek, R. Clark, C. Szabó, 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Evaluation of autophagy using mouse models of brain injury.

P. Kochanek, R. Clark, H. Bayır, 2010, Biochimica et biophysica acta.

Autophagy is Increased after Traumatic Brain Injury in Mice and is Partially Inhibited by the Antioxidant γ-glutamylcysteinyl Ethyl Ester

Simon C Watkins, P. Kochanek, R. Clark, 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Selectively increasing inducible heat shock protein 70 via TAT‐protein transduction protects neurons from nitrosative stress and excitotoxicity

R. Clark, H. Wong, L. Jenkins, 2005, Journal of neurochemistry.

Ascorbate Deficiency Confers Resistance to Hippocampal Neurodegeneration after Asphyxial Cardiac Arrest in Juvenile Rats

P. Kochanek, R. Clark, H. Bayır, 2021, Pediatric Research.

Serum levels of the cold stress hormones FGF21 and GDF-15 after cardiac arrest in infants and children enrolled in single center therapeutic hypothermia clinical trials.

P. Kochanek, R. Clark, A. Fabio, 2021, Resuscitation.

Detecting and quantifying pADPr in vivo.

R. Clark, Y. Lai, R. Aneja, 2011, Methods in molecular biology.

Mass‐spectrometric characterization of phospholipids and their primary peroxidation products in rat cortical neurons during staurosporine‐induced apoptosis

P. Kochanek, R. Clark, H. Bayır, 2008, Journal of neurochemistry.

Protein nitration and poly-ADP-ribosylation in brain after rapid exsanguination cardiac arrest in a rat model of emergency preservation and resuscitation.

P. Kochanek, R. Clark, H. Bayır, 2008, Resuscitation.

Dietary Supplementation With Nonfermentable Fiber Alters the Gut Microbiota and Confers Protection in Murine Models of Sepsis

R. Clark, V. Di Caro, S. Ranganathan, 2017, Critical care medicine.

Autophagy in acute brain injury: Feast, famine, or folly?

P. Kochanek, R. Clark, Craig M. Smith, 2011, Neurobiology of Disease.

Polynitroxylated Pegylated Hemoglobin-A Novel, Small Volume Therapeutic for Traumatic Brain Injury Resuscitation: Comparison to Whole Blood and Dose Response Evaluation.

P. Kochanek, R. Clark, C. Dixon, 2017, Journal of neurotrauma.

Polynitroxylated-Pegylated Hemoglobin Attenuates Fluid Requirements and Brain Edema in Combined Traumatic Brain Injury Plus Hemorrhagic Shock in Mice

P. Kochanek, R. Clark, H. Bayır, 2013, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Alterations in inducible 72‐kDa heat shock protein and the chaperone cofactor BAG‐1 in human brain after head injury

Simon C Watkins, P. Kochanek, D. Marion, 2003, Journal of neurochemistry.

Minocycline Reduces Neuronal Death and Attenuates Microglial Response after Pediatric Asphyxial Cardiac Arrest

P. Kochanek, R. Clark, H. Bayır, 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Polynitroxyl Albumin and Albumin Therapy after Pediatric Asphyxial Cardiac Arrest: Effects on Cerebral Blood Flow and Neurologic Outcome

P. Kochanek, R. Clark, H. Bayır, 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Promising strategies to minimize secondary brain injury after head trauma

P. Kochanek, R. Clark, H. Bayır, 2003, Critical care medicine.

Relationship between hyperglycemia and outcome in children with severe traumatic brain injury

John C. Lin, E. Tyler-Kabara, S. Wisniewski, 2012, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Endothelin-1 is increased in cerebrospinal fluid and associated with unfavorable outcomes in children after severe traumatic brain injury.

S. Wisniewski, P. Kochanek, R. Clark, 2010, Journal of neurotrauma.

Interleukin‐8 is increased in cerebrospinal fluid of children with severe head injury

S. Wisniewski, P. Kochanek, D. Marion, 2000, Critical care medicine.

Acute Encephalitis

R. Clark, Dennis W. Simon, G. Zuccoli, 2013, Critical Care Clinics.

Effect of traumatic brain injury in mice deficient in intercellular adhesion molecule-1: assessment of histopathologic and functional outcome.

P. Kochanek, J. Schiding, D. Marion, 1999, Journal of neurotrauma.

The effect of brain temperature on acute inflammation after traumatic brain injury in rats.

P. Kochanek, J. Schiding, D. Marion, 1997, Journal of neurotrauma.

Preterminal Gasping During Hypoxic Cardiac Arrest Increases Cardiac Function in Immature Rats

R. Clark, K. Tobita, R. Hickey, 2006, Pediatric Research.

The Nuclear Splicing Factor RNA Binding Motif 5 Promotes Caspase Activation in Human Neuronal Cells, and Increases after Traumatic Brain Injury in Mice

P. Kochanek, R. Clark, S. Poloyac, 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Reduced brain edema after traumatic brain injury in mice deficient in P‐selectin and intercellular adhesion molecule‐1

P. Kochanek, D. Marion, R. Clark, 2000 .

Reduced brain edema after traumatic brain injury in mice deficient in P-selectin and intercellular adhesion molecule-1.

P. Kochanek, D. Marion, R. Clark, 1999, Journal of leukocyte biology.

International Survey of Critically Ill Children With Acute Neurologic Insults: The Prevalence of Acute Critical Neurological Disease in Children A Global Epidemiological Assessment Study*

D. Angus, P. Kochanek, R. Clark, 2017, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

20-Hydroxyeicosatetraenoic Acid Inhibition by HET0016 Offers Neuroprotection, Decreases Edema, and Increases Cortical Cerebral Blood Flow in a Pediatric Asphyxial Cardiac Arrest Model in Rats

P. Kochanek, R. Clark, D. Tudorascu, 2015, Journal of Cerebral Blood Flow and Metabolism.

Postcardiac arrest syndrome: focus on the brain

P. Kochanek, R. Clark, M. Manole, 2009, Current opinion in pediatrics.

International Survey of Critically Ill Children With Acute Neurologic Insults: The PANGEA study

D. Angus, P. Kochanek, R. Clark, 2017 .

Feasibility and Performance of a Gel-Adhesive Pad System for Pediatric Targeted Temperature Management: An Exploratory Analysis of 19 Pediatric Critically Ill Patients.

P. Kochanek, R. Clark, Dennis W. Simon, 2020, Therapeutic hypothermia and temperature management.

Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children.

S. Wisniewski, P. Kochanek, S. DeKosky, 1997, Journal of neurotrauma.

Multicenter cohort study of in-hospital pediatric cardiac arrest*

Vinay Nadkarni, Heidi J. Dalton, Kathleen L. Meert, 2009, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Deciphering of Mitochondrial Cardiolipin Oxidative Signaling in Cerebral Ischemia-Reperfusion

P. Kochanek, R. Clark, H. Bayır, 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

729: Whole Brain Diffusion Tensor Imaging Analysis and Outcomes Following Pediatric Cardiac Arrest

V. Schmithorst, P. Kochanek, A. Panigrahy, 2020 .

Susceptibility to meningococcal infection--nature versus nurture?

R. Clark, Y. Conley, A. Sarnaik, 2008, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Neutrophils do not mediate blood-brain barrier permeability early after controlled cortical impact in rats.

P. Kochanek, J. Schiding, D. Marion, 1999, Journal of neurotrauma.

Brain injuries and neurological system failure are the most common proximate causes of death in children admitted to a pediatric intensive care unit*

J. Carcillo, R. Clark, M. Bell, 2011, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Plasma Mitochondrial DNA—a Novel DAMP in Pediatric Sepsis

J. Carcillo, R. Clark, V. Di Caro, 2016, Shock.

Cytochrome c, a Biomarker of Apoptosis, is Increased in Cerebrospinal Fluid from Infants with Inflicted Brain Injury from Child Abuse

S. Wisniewski, P. Kochanek, S. DeKosky, 2005, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Cerebral Regional Oxygen Saturation and Serum Neuromarkers for the Prediction of Adverse Neurologic Outcome in Pediatric Cardiac Surgery

R. Clark, M. Bell, J. Sanchez-de-Toledo, 2014, Neurocritical Care.

Combined Neurotrauma Models: Experimental Models Combining Traumatic Brain Injury and Secondary Insults.

P. Kochanek, R. Clark, Dennis W. Simon, 2016, Methods in molecular biology.

Post–Cardiac Arrest Syndrome Epidemiology, Pathophysiology, Treatment, and Prognostication A Consensus Statement From the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Strok

R. Neumar, C. Callaway, L. Morrison, 2008 .

Resuscitation with epinephrine worsens cerebral capillary no-reflow after experimental pediatric cardiac arrest: An in vivo multiphoton microscopy evaluation

P. Kochanek, A. Vazquez, R. Clark, 2022, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Opioid e-prescribing trends at discharge in a large pediatric health system.

Christopher M. Horvat, P. Kochanek, R. Clark, 2019, Journal of opioid management.

Quinolinic acid in the cerebrospinal fluid of children after traumatic brain injury.

E. Sinz, S. Wisniewski, P. Kochanek, 1999, Critical care medicine.

Is it time to revisit a role for antithrombotic therapy in asphyxia neonatorum?

J. Carcillo, R. Clark, 2004, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Out of the frying pan and into the fire: neurodevelopmental outcome in pediatric intensive care unit survivors of serious brain injury.

R. Clark, 2002, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Antioxidant Tempol Enhances Hypothermic Cerebral Preservation during Prolonged Cardiac Arrest in Dogs

P. Kochanek, R. Clark, P. Safar, 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Severe brief pressure-controlled hemorrhagic shock after traumatic brain injury exacerbates functional deficits and long-term neuropathological damage in mice.

S. Wisniewski, P. Kochanek, R. Clark, 2012, Journal of neurotrauma.

Hemorrhagic shock after experimental traumatic brain injury in mice: effect on neuronal death.

P. Kochanek, R. Clark, H. Bayır, 2009, Journal of neurotrauma.

Blood brain barrier is impermeable to solutes and permeable to water after experimental pediatric cardiac arrest

P. Kochanek, R. Clark, L. Foley, 2014, Neuroscience Letters.

Inducible NOS and Other Novel Mediators of Inflammation in Brain Trauma

E. Sinz, P. Kochanek, D. Marion, 1999 .

Inflammatory Process in the Pathobiology of Secondary Damage After Traumatic Brain Injury

P. Kochanek, S. DeKosky, R. Clark, 1997 .

The relationship between brain temperature and neutrophil accumulation after traumatic brain injury in rats.

P. Kochanek, J. Schiding, D. Marion, 1997, Acta neurochirurgica. Supplement.

Heme Oxygenase 1 in Cerebrospinal Fluid from Infants and Children after Severe Traumatic Brain Injury

P. Kochanek, R. Clark, H. Bayır, 2006, Developmental Neuroscience.

Expression of ATP-Binding Cassette Transporters B1 and C1 after Severe Traumatic Brain Injury in Humans.

P. Kochanek, R. Clark, D. Okonkwo, 2016, Journal of Neurotrauma.

Marked gender effect on lipid peroxidation after severe traumatic brain injury in adult patients.

S. Wisniewski, P. Kochanek, D. Marion, 2004, Journal of neurotrauma.

Detection of brain specific cardiolipins in plasma after experimental pediatric head injury

P. Kochanek, R. Clark, H. Bayır, 2019, Experimental Neurology.

Excitatory amino acid concentrations in ventricular cerebrospinal fluid after severe traumatic brain injury in infants and children: the role of child abuse.

S. Wisniewski, P. Kochanek, D. Marion, 2001, The Journal of pediatrics.

Influence of PARP-1 polymorphisms in patients after traumatic brain injury.

Taura L. Barr, P. Kochanek, R. Clark, 2010, Journal of neurotrauma.

The Th1 versus Th2 cytokine profile in cerebrospinal fluid after severe traumatic brain injury in infants and children

S. Wisniewski, P. Kochanek, S. DeKosky, 2001, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Neuron-specific enolase and S100B in cerebrospinal fluid after severe traumatic brain injury in infants and children.

S. Wisniewski, P. Kochanek, R. Clark, 2002, Pediatrics.

Healthcare Use in the Year Following Bronchiolitis Hospitalization.

Christopher M. Horvat, P. Kochanek, R. Clark, 2022, Hospital pediatrics.

ABCG2 c.421C>A Is Associated with Outcomes after Severe Traumatic Brain Injury.

Solomon M. Adams, P. Kochanek, R. Clark, 2018, Journal of neurotrauma.

Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor.

Simon C Watkins, R. Clark, H. Bayır, 2018, ACS chemical biology.

ABCC8 Single Nucleotide Polymorphisms are Associated with Cerebral Edema in Severe TBI

P. Kochanek, R. Clark, D. Okonkwo, 2017, Neurocritical Care.

Soluble adhesion molecules in CSF are increased in children with severe head injury.

S. Wisniewski, P. Kochanek, S. DeKosky, 1998, Journal of neurotrauma.

Selective early cardiolipin peroxidation after traumatic brain injury: an oxidative lipidomics analysis

Rosa Viner, P. Kochanek, R. Clark, 2007, Annals of neurology.

Multiplex assessment of cytokine and chemokine levels in cerebrospinal fluid following severe pediatric traumatic brain injury: effects of moderate hypothermia.

S. Wisniewski, P. Kochanek, R. Clark, 2007, Journal of neurotrauma.

Administration of adenosine receptor agonists or antagonists after controlled cortical impact in mice: effects on function and histopathology

P. Kochanek, J. Melick, R. Clark, 2002, Brain Research.

An acute inflammatory response to the use of granulocyte colony-stimulating factor to prevent infections in patients with brain injury: what about the brain?

P. Kochanek, R. Clark, M. Whalen, 1999, Critical care medicine.

Retinal Hemorrhages Associated With Spinal Cord Arteriovenous Malformation

R. Clark, R. Orr, R. Towbin, 1995, La Clinica pediatrica.

A gel-based proteomic comparison of human cerebrospinal fluid between inflicted and non-inflicted pediatric traumatic brain injury.

D. Allen, G. Omenn, P. Kochanek, 2007, Journal of neurotrauma.

Faculty Opinions recommendation of Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction, and neuronal death.

R. Clark, 2006 .

Poly(ADP-Ribose) Polymerase 1-Sirtuin 1 Functional Interplay Regulates LPS-Mediated High Mobility Group Box 1 Secretion

R. Clark, T. Billiar, J. Piganelli, 2014, Molecular medicine.

The FDA warning against prolonged sedation with propofol in children remains warranted.

J. Carcillo, R. Clark, K. Felmet, 2003, Pediatrics.

HBO: It's not ready for prime time for the treatment of acute central nervous system trauma.

P. Kochanek, R. Clark, L. Jenkins, 2001, Critical care medicine.

DNA Viremia Is Associated with Hyperferritinemia in Pediatric Sepsis.

J. Carcillo, R. Clark, G. Storch, 2019, The Journal of pediatrics.

Brain Resuscitation in the Drowning Victim

R. Berg, V. Nadkarni, P. Kochanek, 2012, Neurocritical Care.

Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients

Christopher M. Horvat, S. Wisniewski, M. Wintermark, 2020, Journal of neurotrauma.

Chapter 62 – Hypoxic-Ischemic Encephalopathy: Pathobiology and Therapy of the Post-Resuscitation Syndrome in Children

P. Kochanek, R. Clark, E. Fink, 2011 .

Chapter 58 – Hypoxic-Ischemic Encephalopathy: Pathobiology and Therapy of the Postresuscitation Syndrome in Children

P. Kochanek, R. Clark, P. Safar, 2006 .

Experimental model of pediatric asphyxial cardiopulmonary arrest in rats

P. Kochanek, R. Clark, C. D. Marco, 2004, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Consensus Process

R. Neumar, C. Callaway, L. Morrison, 2022 .

Epidemiology, Pathophysiology, Treatment, and Prognostication A Consensus Statement From the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, Inter

C. Callaway, L. Morrison, R. Berg, 2008 .

Pathobiology of Secondary Brain Injury

P. Kochanek, R. Clark, L. Jenkins, 2012 .

To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways

R. Clark, Xiao-Ming Yin, D. Henshall, 2003, Progress in Neurobiology.

Intranuclear localization of apoptosis‐inducing factor (AIF) and large scale dna fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite

Simon C Watkins, P. Kochanek, R. Clark, 2002, Journal of neurochemistry.

Bench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injury

P. Kochanek, R. Clark, L. Jenkins, 2004, Critical care.

Caspase‐3 Mediated Neuronal Death After Traumatic Brain Injury in Rats

Simon C Watkins, P. Kochanek, J. Melick, 2000, Journal of neurochemistry.

Apoptosis-Suppressor Gene bcl-2 Expression after Traumatic Brain Injury in Rats

Simon C Watkins, P. Kochanek, R. Clark, 1997, The Journal of Neuroscience.

Opportunities for the repurposing of PARP inhibitors for the therapy of non‐oncological diseases

S. Snyder, R. Clark, N. Curtin, 2018, British journal of pharmacology.

Trends in US Pediatric Hospital Admissions in 2020 Compared With the Decade Before the COVID-19 Pandemic

Christopher M. Horvat, R. Clark, D. Fuhrman, 2021, JAMA network open.

Isoflurane improves long-term neurologic outcome versus fentanyl after traumatic brain injury in rats.

S. Wisniewski, P. Kochanek, K. Statler, 2000, Journal of neurotrauma.

Aiming for the target: Mitochondrial drug delivery in traumatic brain injury

R. Clark, H. Bayır, T. Anthonymuthu, 2019, Neuropharmacology.

Bcl-2 family gene products in cerebral ischemia and traumatic brain injury.

R. Clark, Jun Chen, S. Graham, 2000, Journal of neurotrauma.

Conventional and functional proteomics using large format two-dimensional gel electrophoresis 24 hours after controlled cortical impact in postnatal day 17 rats.

P. Kochanek, D. Marion, R. Clark, 2002, Journal of neurotrauma.

Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: diagnosis, prognosis, probing mechanisms, and therapeutic decision making

Rachel P Berger, P. Kochanek, R. Clark, 2008, Current opinion in critical care.

Disruption of Bax protein prevents neuronal cell death but produces cognitive impairment in mice following traumatic brain injury.

P. Kochanek, R. Clark, C. Dixon, 2008, Journal of neurotrauma.

Innate Gender-based Proclivity in Response to Cytotoxicity and Programmed Cell Death Pathway*

Simon C Watkins, P. Kochanek, R. Clark, 2004, Journal of Biological Chemistry.

Posttranslational protein modifications.

R. Clark, H. Bayır, L. Jenkins, 2005, Critical care medicine.

Increases in bcl-2 protein in cerebrospinal fluid and evidence for programmed cell death in infants and children after severe traumatic brain injury.

S. Wisniewski, P. Kochanek, J. Carcillo, 2000, The Journal of pediatrics.

Increases in Bcl‐2 and cleavage of caspase‐1 and caspase‐3 in human brain after head injury

Simon C Watkins, P. Kochanek, D. Marion, 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Prolonged Lymphopenia, Lymphoid Depletion, and Hypoprolactinemia in Children with Nosocomial Sepsis and Multiple Organ Failure1

J. Carcillo, R. Clark, R. Jaffe, 2005, The Journal of Immunology.

Early Axonal Injury and Delayed Cytotoxic Cerebral Edema are Associated With Microglial Activation in a Mouse Model of Sepsis.

P. Kochanek, A. Panigrahy, R. Clark, 2019, Shock.

Alterations in bcl-2 and caspase gene family protein expression in human temporal lobe epilepsy

Simon C Watkins, R. Clark, R. Simon, 2000, Neurology.

Adenosine A1 Receptor Knockout Mice Develop Lethal Status Epilepticus after Experimental Traumatic Brain Injury

P. Kochanek, R. Clark, P. Crumrine, 2006, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Severe controlled cortical impact in rats: assessment of cerebral edema, blood flow, and contusion volume.

P. Kochanek, J. Schiding, D. Marion, 1995, Journal of neurotrauma.

Factors Contributing to Fentanyl Pharmacokinetic Variability Among Diagnostically Diverse Critically Ill Children

Christopher M. Horvat, P. Kochanek, R. Clark, 2019, Clinical Pharmacokinetics.

ABCB1 Genotype is Associated with Fentanyl Requirements in Critically Ill Children

Christopher M. Horvat, P. Kochanek, R. Clark, 2017, Pediatric Research.

Assessment of Dynamic Intracranial Compliance in Children with Severe Traumatic Brain Injury: Proof-of-Concept

Christopher M. Horvat, G. Clermont, P. Kochanek, 2020, Neurocritical Care.

Chapter 61 – Severe Traumatic Brain Injury in Infants and Children

P. Kochanek, R. Clark, H. Bayır, 2011 .

Hyperglycolysis is exacerbated after traumatic brain injury with fentanyl vs. isoflurane anesthesia in rats

P. Kochanek, J. Melick, K. Statler, 2003, Brain Research.

Relationship Between Increases in Pancreatic Enzymes and Cerebral Events in Children After Traumatic Brain Injury

S. Wisniewski, P. Kochanek, R. Clark, 2009, Neurocritical care.

Factors Associated With Neurobehavioral Complications in Pediatric Abdominal Organ Transplant Recipients Identified Using Computable Composite Definitions*

Christopher M. Horvat, R. Clark, G. Mazariegos, 2020, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

The far-reaching scope of neuroinflammation after traumatic brain injury

P. Kochanek, R. Clark, H. Bayır, 2017, Nature Reviews Neurology.

Repetitive Mild Traumatic Brain Injury in the Developing Brain: Effects on Long-Term Functional Outcome and Neuropathology.

P. Kochanek, R. Clark, H. Bayır, 2016, Journal of neurotrauma.

Cerebrospinal Fluid NLRP3 is Increased After Severe Traumatic Brain Injury in Infants and Children

P. Kochanek, R. Clark, H. Bayır, 2017, Neurocritical Care.

Depletion of gut microbiota is associated with improved neurologic outcome following traumatic brain injury

P. Kochanek, R. Clark, J. Ozolek, 2020, Brain Research.

Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats.

P. Kochanek, K. Statler, R. Clark, 2006, Journal of neurotrauma.

Neuron-Specific Enolase and S 100 B in Cerebrospinal Fluid After Severe Traumatic Brain Injury in Infants and Children

S. Wisniewski, P. Kochanek, R. Clark, 2002 .

Ischemia-induced autophagy contributes to neurodegeneration in cerebellar Purkinje cells in the developing rat brain and in primary cortical neurons in vitro.

Hülya Bayır, Mioara D Manole, P. Kochanek, 2015, Biochimica et biophysica acta.

Membrane transporters in traumatic brain injury: Pathological, pharmacotherapeutic, and developmental implications

Solomon M. Adams, P. Kochanek, R. Clark, 2019, Experimental Neurology.

Normoxic versus hyperoxic resuscitation in pediatric asphyxial cardiac arrest: Effects on oxidative stress

P. Kochanek, R. Clark, H. Bayır, 2011, Critical care medicine.

Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans.

S. Wisniewski, S. DeKosky, R. Clark, 2007, Archives of neurology.

Influence of ATP-Binding Cassette Polymorphisms on Neurological Outcome After Traumatic Brain Injury

P. Kochanek, R. Clark, D. Okonkwo, 2013, Neurocritical Care.

Effect of neutropenia and granulocyte colony stimulating factor-induced neutrophilia on blood-brain barrier permeability and brain edema after traumatic brain injury in rats

S. Wisniewski, P. Kochanek, J. Melick, 2000, Critical care medicine.

Neutrophil accumulation after traumatic brain injury in rats: comparison of weight drop and controlled cortical impact models.

P. Kochanek, J. Schiding, D. Marion, 1994, Journal of neurotrauma.

Antibodies against Mac-1 attenuate neutrophil accumulation after traumatic brain injury in rats.

P. Kochanek, J. Schiding, S. DeKosky, 1996, Journal of neurotrauma.

Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury

John Q. Trojanowski, Stephen R. Wisniewski, Steven T. DeKosky, 2004, Experimental Neurology.

Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice

Simon C Watkins, E. Sinz, S. Wisniewski, 1999 .

Hypothermia Decreases Cerebrospinal Fluid Asymmetric Dimethylarginine Levels in Children With Traumatic Brain Injury

E. Tyler-Kabara, P. Kochanek, R. Clark, 2013, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

“Take a Number”—Precision Monitoring Directs Precision Therapy

P. Kochanek, R. Clark, R. Jha, 2020, Neurocritical Care.

Cerebrospinal fluid and plasma nitrite and nitrate concentrations after head injury in humans.

S. Wisniewski, P. Kochanek, D. Marion, 1996, Critical care medicine.

Translocation of Apoptosis-Inducing Factor in Vulnerable Neurons after Transient Cerebral Ischemia and in Neuronal Cultures after Oxygen-Glucose Deprivation

R. Clark, F. Sun, Jun Chen, 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Critical Role of Calpain I in Mitochondrial Release of Apoptosis-Inducing Factor in Ischemic Neuronal Injury

R. Clark, Xiao-Ming Yin, A. Liou, 2007, The Journal of Neuroscience.

Intra-mitochondrial Poly(ADP-ribosylation) Contributes to NAD+ Depletion and Cell Death Induced by Oxidative Stress*

Simon C Watkins, P. Kochanek, Y. Han, 2003, The Journal of Biological Chemistry.

sFas and sFas Ligand and Pediatric Sepsis-Induced Multiple Organ Failure Syndrome

J. Carcillo, R. Clark, L. Doughty, 2002, Pediatric Research.

Cerebrospinal fluid Sulfonylurea Receptor-1 is associated with intracranial pressure and outcome after pediatric TBI-an exploratory analysis of the Cool Kids Trial.

S. Wisniewski, P. Kochanek, R. Clark, 2021, Journal of neurotrauma.

Isoflurane exerts neuroprotective actions at or near the time of severe traumatic brain injury

P. Kochanek, K. Statler, R. Clark, 2006, Brain Research.

Caspase inhibition therapy abolishes brain trauma-induced increases in Aβ peptide: Implications for clinical outcome

S. DeKosky, R. Clark, M. Ikonomovic, 2006, Experimental Neurology.

Emerging Therapies in Traumatic Brain Injury

P. Kochanek, R. Clark, H. Bayır, 2015, Seminars in Neurology.

Autophagy in Critical Illness

R. Clark, Alicia K. Au, R. Aneja, 2015 .

Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice.

Simon C Watkins, E. Sinz, S. Wisniewski, 1999, The Journal of clinical investigation.

Intracranial and Cerebral Perfusion Pressure Thresholds Associated With Inhospital Mortality Across Pediatric Neurocritical Care.

Christopher M. Horvat, P. Kochanek, R. Clark, 2020, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injury.

Valerian Kagan, P. Kochanek, R. Clark, 2011, Journal of neurotrauma.

C-Reactive Protein and Ferritin Are Associated With Organ Dysfunction and Mortality in Hospitalized Children

Christopher M. Horvat, J. Carcillo, R. Clark, 2019, Clinical pediatrics.

Effect of dietary cellulose supplementation on gut barrier function and apoptosis in a murine model of endotoxemia

R. Clark, V. Di Caro, M. Morowitz, 2019, PloS one.

Sustained Dysbiosis and Decreased Fecal Short Chain Fatty Acids after Traumatic Brain Injury and Impact on Neurologic Outcome.

P. Kochanek, R. Clark, H. Bayır, 2021, Journal of neurotrauma.

Critical mechanisms of secondary damage after inflicted head injury in infants and children.

P. Kochanek, R. Clark, H. Bayır, 2002, Neurosurgery clinics of North America.

Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication: a scientific statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia;

R. Neumar, C. Callaway, L. Morrison, 2009, International emergency nursing.

Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication: A scientific statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia;

R. Neumar, C. Callaway, L. Morrison, 2009, International emergency nursing.

Pre-clinical models in pediatric traumatic brain injury—challenges and lessons learned

P. Kochanek, R. Clark, H. Bayır, 2017, Child's Nervous System.

Considerations for Chronic Recovery after Traumatic Brain Injury

P. Kochanek, R. Clark, C. Dixon, 2015 .

Key Issues in Pediatric Neurointensive Care

P. Kochanek, R. Clark, H. Bayır, 2011 .

Cold stress protein RBM3 responds to temperature change in an ultra-sensitive manner in young neurons

P. Kochanek, R. Clark, M. Manole, 2015, Neuroscience.

"Lost in translation?" Noninvasive cerebral monitoring after cardiac arrest.

P. Kochanek, R. Clark, M. Manole, 2011, Critical care medicine.

A tertiary care center's experience with therapeutic hypothermia after pediatric cardiac arrest*

P. Kochanek, R. Clark, R. S. Watson, 2010, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Current and future therapies of pediatric cardiopulmonary arrest

P. Kochanek, R. Clark, R. Hickey, 2008, Indian journal of pediatrics.

Neurological Complications Acquired During Pediatric Critical Illness: Exploratory “Mixed Graphical Modeling” Analysis Using Serum Biomarker Levels

Christopher M. Horvat, P. Kochanek, R. Clark, 2021, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Personalising Outcomes after Child Cardiac Arrest (POCCA): design and recruitment challenges of a multicentre, observational study

P. Kochanek, A. Panigrahy, J. Wisnowski, 2020, BMJ Open.

Brain MR imaging and spectroscopy for outcome prognostication after pediatric cardiac arrest.

C. Callaway, D. Angus, P. Kochanek, 2020, Resuscitation.

Resuscitation from severe brain trauma.

P. Kochanek, D. Marion, S. DeKosky, 1996, Critical care medicine.

Comparison of the interleukin-6 and interleukin-10 response in children after severe traumatic brain injury or septic shock.

P. Kochanek, S. DeKosky, J. Carcillo, 1997, Acta neurochirurgica. Supplement.

Development and Performance of Electronic Pediatric Risk of Mortality and Pediatric Logistic Organ Dysfunction-2 Automated Acuity Scores.

Christopher M. Horvat, Henry A. Ogoe, P. Kochanek, 2019, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Regionally clustered ABCC8 polymorphisms in a prospective cohort predict cerebral oedema and outcome in severe traumatic brain injury

Theresa A. Koleck, P. Kochanek, R. Clark, 2018, Journal of Neurology, Neurosurgery, and Psychiatry.

Biochemical, cellular, and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: Lessons learned from the bedside

P. Kochanek, D. Marion, R. Clark, 2000, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Traumatic brain injury in infants and children: mechanisms of secondary damage and treatment in the intensive care unit.

P. Kochanek, R. Clark, H. Bayır, 2003, Critical care clinics.

Key Mechanisms of Secondary Neuronal Damage After Brain Trauma

P. Kochanek, R. Clark, R. Clark, 2002 .

Transgenic mice that overexpress the anti-apoptotic Bcl-2 protein have improved histological outcome but unchanged behavioral outcome after traumatic brain injury

P. Kochanek, R. Clark, C. Dixon, 2006, Brain Research.

The simple model versus the super model: translating experimental traumatic brain injury research to the bedside.

P. Kochanek, K. Statler, D. Marion, 2001, Journal of neurotrauma.

Minocycline Attenuates High Mobility Group Box 1 Translocation, Microglial Activation, and Thalamic Neurodegeneration after Traumatic Brain Injury in Post-Natal Day 17 Rats.

P. Kochanek, R. Clark, H. Bayır, 2018, Journal of neurotrauma.

Increased CSF Concentrations of Myelin Basic Protein After TBI in Infants and Children: Absence of Significant Effect of Therapeutic Hypothermia

P. D. Adelson, E. Tyler-Kabara, S. Wisniewski, 2012, Neurocritical Care.

Dietary Cellulose Supplementation Modulates the Immune Response in a Murine Endotoxemia Model

R. Clark, V. Di Caro, M. Morowitz, 2019, Shock.

Quantitative and qualitative assessment of glymphatic flux using Evans blue albumin

Hülya Bayır, Henry Alexander, P. Kochanek, 2019, Journal of Neuroscience Methods.

Vascular Endothelial Growth Factor Is Increased in Cerebrospinal Fluid after Traumatic Brain Injury in Infants and Children

S. Wisniewski, P. Kochanek, R. Clark, 2004, Neurosurgery.

Relationship of Intracranial Pressure and Cerebral Perfusion Pressure with Outcome in Young Children after Severe Traumatic Brain Injury

E. Tyler-Kabara, S. Wisniewski, P. Kochanek, 2010, Developmental Neuroscience.

Barriers to Drug Delivery for Brain Trauma

P. Kochanek, R. Clark, P. Empey, 2014 .

Continuous versus intermittent cerebrospinal fluid drainage after severe traumatic brain injury in children: effect on biochemical markers.

S. Wisniewski, P. Kochanek, R. Clark, 2004, Journal of neurotrauma.

The pharmacogenomics of severe traumatic brain injury.

Yvette P Conley, Solomon M. Adams, P. Kochanek, 2017, Pharmacogenomics.

Cerebrospinal fluid adenosine concentration and uncoupling of cerebral blood flow and oxidative metabolism after severe head injury in humans.

P. Kochanek, D. Marion, J. Carcillo, 1997, Neurosurgery.

Inducible Nitric Oxide Synthase Expression in Cerebrovascular Smooth Muscle and Neutrophils after Traumatic Brain Injury in Immature Rats1

Simon C Watkins, P. Kochanek, J. Schiding, 1996, Pediatric Research.

Unmasking sex-based disparity in neuronal metabolism.

P. Kochanek, R. Clark, H. Bayır, 2011, Current pharmaceutical design.

Brain Oral Session: Traumatic Brain Injury—Metabolism

P. Kochanek, R. Clark, Y. Conley, 2009 .

Brief Induced Hypothermia Improves Outcome after Asphyxial Cardiopulmonary Arrest in Juvenile Rats

P. Kochanek, R. Clark, C. D. Marco, 2005, Developmental Neuroscience.

Screening of biochemical and molecular mechanisms of secondary injury and repair in the brain after experimental blast-induced traumatic brain injury in rats.

P. Kochanek, R. Clark, H. Bayır, 2013, Journal of neurotrauma.

INTERLEUKIN-8 IS INCREASED IN CSF OF CHILDREN WITH SEVERE TRAUMATIC BRAIN INJURY

P. Kochanek, S. DeKosky, R. Clark, 1998 .

CSF Bcl-2 and cytochrome C temporal profiles in outcome prediction for adults with severe TBI

P. Kochanek, R. Clark, H. Bayır, 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Alterations in Cerebral Blood Flow after Resuscitation from Cardiac Arrest

R. Clark, B. Iordanova, M. Manole, 2017, Front. Pediatr..

Brain tissue oxygen monitoring identifies cortical hypoxia and thalamic hyperoxia after experimental pediatric cardiac arrest

P. Kochanek, R. Clark, H. Bayır, 2013, Pediatric Research.

Increases in Cerebrospinal Fluid Caffeine Concentration are Associated with Favorable Outcome after Severe Traumatic Brain injury in Humans

S. Wisniewski, P. Kochanek, R. Clark, 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

The Safar Center for Resuscitation Research: Searching for Breakthroughs in the New Millennium

P. Kochanek, R. Clark, H. Bayır, 2006 .

The role of autophagy in acute brain injury: A state of flux?

P. Kochanek, R. Clark, H. Bayır, 2019, Neurobiology of Disease.

Gel-Based Hippocampal Proteomic Analysis 2 Weeks following Traumatic Brain Injury to Immature Rats Using Controlled Cortical Impact

R. Clark, C. Dixon, L. Jenkins, 2006, Developmental Neuroscience.

Cerebrospinal fluid biomarkers versus glasgow coma scale and glasgow outcome scale in pediatric traumatic brain injury: the role of young age and inflicted injury.

P. Kochanek, R. Clark, H. Bayır, 2007, Journal of neurotrauma.

Magnetic Resonance Imaging Assessment of Regional Cerebral Blood Flow after Asphyxial Cardiac Arrest in Immature Rats

P. Kochanek, R. Clark, H. Bayır, 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Increased Phosphorylation of Protein Kinase B and Related Substrates after Traumatic Brain Injury in Humans and Rats

P. Kochanek, D. Marion, S. DeKosky, 2006, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

ENDOTHELIN-1 IS INCREASED IN CEREBROSPINAL FLUID FOLLOWING TRAUMATIC BRAIN INJURY IN CHILDREN

P. Kochanek, D. Marion, R. Clark, 1999 .

Identification of poly‐ADP‐ribosylated mitochondrial proteins after traumatic brain injury

Simon C Watkins, P. Kochanek, R. Clark, 2008, Journal of neurochemistry.

How I Cool Children in Neurocritical Care

P. Kochanek, R. Clark, M. Bell, 2010, Neurocritical care.

Probenecid and N-Acetylcysteine Prevent Loss of Intracellular Glutathione and Inhibit Neuronal Death after Mechanical Stretch Injury In Vitro.

P. Kochanek, R. Clark, H. Bayır, 2016, Journal of neurotrauma.

Immunohistochemical analysis of histone H3 acetylation and methylation--evidence for altered epigenetic signaling following traumatic brain injury in immature rats.

P. Kochanek, R. Clark, C. Dixon, 2006 .

Don't forget the "single chromosome polymorphism": a need for gender-stratification in pediatric patients?

R. Clark, E. Fink, 2004, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Increased cytochrome c in rat cerebrospinal fluid after cardiac arrest and its effects on hypoxic neuronal survival.

R. Clark, Sunita Shinde, R. Hickey, 2012, Resuscitation.

Temporal Profile of Transporter mRNA Expression in the Brain after Traumatic Brain Injury in Developing Rats

Solomon M. Adams, P. Kochanek, R. Clark, 2019, bioRxiv.

No pain, no gain in pediatric sepsis?*.

R. Clark, R. S. Watson, Dennis W. Simon, 2014, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Physiological assessment and control in studies evaluating central nervous system injury: should size matter?

P. Kochanek, K. Statler, R. Clark, 2006, Anesthesia and Analgesia.

Cerebral microcirculatory alterations and the no-reflow phenomenon in vivo after experimental pediatric cardiac arrest

Simon C Watkins, P. Kochanek, A. Vazquez, 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Enduring Disturbances in Regional Cerebral Blood Flow and Brain Oxygenation at 24 Hours after Asphyxial Cardiac Arrest in Developing Rats

P. Kochanek, A. Vazquez, R. Clark, 2016, Pediatric Research.

Under Pressure: Defining Management Goals for Pediatric Traumatic Brain Injury.

R. Clark, Megan Browning, 2015, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Mitochondrial Heat Shock Protein 60 Is Increased in Cerebrospinal Fluid following Pediatric Traumatic Brain Injury

S. Wisniewski, P. Kochanek, R. Clark, 2006, Developmental Neuroscience.

Trends in Bronchiolitis ICU Admissions and Ventilation Practices: 2010–2019

R. Clark, D. Fuhrman, Alicia K. Au, 2021, Pediatrics.

Brain-systemic temperature gradient is temperature-dependent in children with severe traumatic brain injury

P. Kochanek, R. Clark, H. Bayır, 2011, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Augmented neuronal death in CA3 hippocampus following hyperventilation early after controlled cortical impact.

P. Kochanek, J. Schiding, D. Marion, 1998, Journal of neurosurgery.

Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury

Bedda L. Rosario, S. Wisniewski, P. Kochanek, 2022, JAMA network open.

Regional Brain Injury on Conventional and Diffusion Weighted MRI is Associated with Outcome After Pediatric Cardiac Arrest

P. Kochanek, A. Panigrahy, D. Landsittel, 2013, Neurocritical Care.

Chapter 62 – Hypoxic-Ischemic Encephalopathy: Pathobiology and Therapy of the Post-Resuscitation Syndrome in Children

P. Kochanek, R. Clark, E. Fink, 2011 .

Association of Severe Hyperoxemia Events and Mortality Among Patients Admitted to a Pediatric Intensive Care Unit

Christopher M. Horvat, S. Venkataraman, R. Clark, 2019, JAMA network open.

Clinical Deterioration and Neurocritical Care Utilization in Pediatric Patients With Glasgow Coma Scale Score of 9–13 After Traumatic Brain Injury: Associations With Patient and Injury Characteristics

Christopher M. Horvat, E. Tyler-Kabara, P. Kochanek, 2021, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Rodent Model of Pediatric Asphyxial Cardiac Arrest

R. Clark, R. Hickey, H. Alexander, 2019, Springer Series in Translational Stroke Research.

Pharmacological Inhibition of Pleckstrin Homology Domain Leucine-Rich Repeat Protein Phosphatase Is Neuroprotective: Differential Effects on Astrocytes

P. Kochanek, R. Clark, H. Bayır, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Comparative Effectiveness of Diversion of Cerebrospinal Fluid for Children With Severe Traumatic Brain Injury

Bedda L. Rosario, S. Wisniewski, P. Kochanek, 2022, JAMA network open.

Adenovirus-mediated transfer and expression of beta-gal in injured hippocampus after traumatic brain injury in mice.

P. Kochanek, D. Marion, R. Clark, 2001, Journal of neurotrauma.

Soluble Fas Receptor (sFasR) in Pediatric Sepsis-Induced MOF

J. Carcillo, R. Clark, L. Doughty, 1998 .

Minocycline Attenuates High Mobility Group Box 1 Translocation, Microglial Activation, and Thalamic Neurodegeneration after Traumatic Brain Injury in Post-Natal Day 17 Rats.

P. Kochanek, R. Clark, H. Bayır, 2018, Journal of neurotrauma.

Deciphering of Mitochondrial Cardiolipin Oxidative Signaling in Cerebral Ischemia-Reperfusion

P. Kochanek, R. Clark, H. Bayır, 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A Scientific Statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia;

R. Neumar, C. Callaway, L. Morrison, 2008, Resuscitation.

Thalamocortical Dysfunction and Thalamic Injury after Asphyxial Cardiac Arrest in Developing Rats

D. Simons, P. Kochanek, R. Clark, 2012, The Journal of Neuroscience.

CEREBROSPINAL FLUID ADENOSINE AND CEREBRAL BLOOD FLOW AND METABOLISM AFTER HUMAN HEAD INJURY.

P. Kochanek, D. Marion, J. Carcillo, 1995 .

Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Str

R. Neumar, C. Callaway, L. Morrison, 2008, Circulation.

Polynitroxyl Albumin and Albumin Therapy after Pediatric Asphyxial Cardiac Arrest: Effects on Cerebral Blood Flow and Neurologic Outcome

P. Kochanek, R. Clark, H. Bayır, 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Ischemic Mechanisms in Traumatic Brain Injury

Donald S. Williams, K. Hendrich, P. Kochanek, 2003 .