S. Hufeisen

发表

Predicting new molecular targets for known drugs

Michael J. Keiser, J. Irwin, B. Shoichet, 2009, Nature.

A Gαs DREADD Mouse for Selective Modulation of cAMP Production in Striatopallidal Neurons

T. Daigle, J. Wess, Xi-Ping Huang, 2013, Neuropsychopharmacology.

Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.

Bryan L Roth, V. Setola, Xi-Ping Huang, 2010, Assay and drug development technologies.

Isolation, detection, and amplification of intact mRNA from dermatome strips, epidermal sheets, and sorted epidermal cells.

S. Hufeisen, G. Wood, R. Eckert, 1991, Journal of Investigative Dermatology.

The in vitro pharmacology of the β-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned β-adrenergic receptors and moderate affinity for the human 5-HT1A receptor

B. Roth, S. Hufeisen, P. Ernsberger, 2001, Psychopharmacology.

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs

Vadim Cherezov, Vsevolod Katritch, Bryan L Roth, 2014, Nature Communications.

Evidence for Possible Involvement of 5-HT2B Receptors in the Cardiac Valvulopathy Associated With Fenfluramine and Other Serotonergic Medications

B. Roth, S. Hufeisen, J. Savage, 2000, Circulation.

Retinoid-dependent transcriptional suppression of cytokeratin gene expression in human epidermal squamous cell carcinoma cells.

S. Hufeisen, R. Eckert, E. Rorke, 1993, Differentiation; research in biological diversity.

2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.

B. Roth, S. Hufeisen, R. Glennon, 2000, Journal of medicinal chemistry.

In Vitro Characterization of Ephedrine-Related Stereoisomers at Biogenic Amine Transporters and the Receptorome Reveals Selective Actions as Norepinephrine Transporter Substrates

B. Roth, S. Hufeisen, R. Glennon, 2003, Journal of Pharmacology and Experimental Therapeutics.

The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine’s actions?

B. Roth, S. Hufeisen, H. Meltzer, 2005, Psychopharmacology.

Pharmacologic analysis of non-synonymous coding h5-HT2A SNPs reveals alterations in atypical antipsychotic and agonist efficacies

Ryan T. Strachan, V. Setola, B. Roth, 2006, The Pharmacogenomics Journal.

l-Homocysteine Sulfinic Acid and Other Acidic Homocysteine Derivatives Are Potent and Selective Metabotropic Glutamate Receptor Agonists

J. Nadeau, B. Roth, S. Hufeisen, 2003, Journal of Pharmacology and Experimental Therapeutics.

2‐Substituted Tryptamines: Agents with Selectivity for 5‐HT6 Serotonin Receptors.

B. Roth, S. Hufeisen, R. Glennon, 2000 .

3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.

V. Setola, B. Roth, S. Hufeisen, 2003, Molecular pharmacology.

In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs

B. Roth, S. Hufeisen, P. Ernsberger, 2002, Psychopharmacology.

Salvinorin A, an Active Component of the Hallucinogenic Sage Salvia divinorum Is a Highly Efficacious κ-Opioid Receptor Agonist: Structural and Functional Considerations

Bryan L Roth, B. Roth, S. Hufeisen, 2004, Journal of Pharmacology and Experimental Therapeutics.

Cell-type specific effects of endocytosis inhibitors on 5-hydroxytryptamine2A receptor desensitization and resensitization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells

B. Roth, S. Hufeisen, D. Sheffler, 2001 .

Cell-type specific effects of endocytosis inhibitors on 5-hydroxytryptamine(2A) receptor desensitization and resensitization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells.

B. Roth, S. Hufeisen, D. Sheffler, 2001, Molecular Pharmacology.

H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs

Paul Ernsberger, Bryan L Roth, Herbert Y Meltzer, 2003, Neuropsychopharmacology.

p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling.

A. Deutch, B. Roth, S. Hufeisen, 2006, Proceedings of the National Academy of Sciences of the United States of America.

The PDZ-binding domain is essential for the dendritic targeting of 5-HT2A serotonin receptors in cortical pyramidal neurons in vitro

B. Roth, S. Hufeisen, J. A. Gray, 2003, Neuroscience.

3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.

V. Setola, B. Roth, S. Hufeisen, 2003, Molecular pharmacology.

Predicting new molecular targets for known drugs

Michael J. Keiser, J. Irwin, B. Shoichet, 2009, Nature.

l‐Homocysteine Sulfinic Acid and l‐Homocysteic Acid Stimulate Phosphoinositide Hydrolysis in Rat Cortical Neurons

Bryan L. Roth, S. Hufeisen, J. Wroblewski, 2003, Annals of the New York Academy of Sciences.