G. Ast

发表

Intronic sequences flanking alternatively spliced exons are conserved between human and mouse.

R. Sorek, G. Ast, 2003, Genome research.

How prevalent is functional alternative splicing in the human genome?

R. Shamir, R. Sorek, G. Ast, 2004, Trends in genetics : TIG.

Comparative analysis identifies exonic splicing regulatory sequences--The complex definition of enhancers and silencers.

G. Ast, T. Pupko, Oren Ram, 2006, Molecular cell.

Chromatin organization marks exon-intron structure

G. Ast, Schraga Schwartz, E. Meshorer, 2009, Nature Structural &Molecular Biology.

Alternative splicing and evolution: diversification, exon definition and function

G. Ast, Hadas Keren, Galit Lev-Maor, 2010, Nature Reviews Genetics.

DNA methylation directs microRNA biogenesis in mammalian cells

G. Ast, Carmit Levy, Galit Lev-Maor, 2019, Nature Communications.

HP1 is involved in regulating the global impact of DNA methylation on alternative splicing.

Karsten Rippe, Gil Ast, Eran Meshorer, 2015, Cell reports.

Regulation of alternative splicing through coupling with transcription and chromatin structure.

Gil Ast, I. Schor, A. Kornblihtt, 2015, Annual review of biochemistry.

The alternative role of DNA methylation in splicing regulation.

G. Ast, Ahuvi Yearim, Galit Lev Maor, 2015, Trends in genetics : TIG.

DNA-methylation effect on cotranscriptional splicing is dependent on GC architecture of the exon–intron structure

G. Ast, Ahuvi Yearim, S. Gelfman, 2013, Genome research.

intron structure − on GC architecture of the exon DNA-methylation effect on cotranscriptional splicing is dependent Material Supplemental

G. Ast, Ahuvi Yearim, S. Gelfman, 2013 .

Expanding the MYBPC1 phenotypic spectrum: a novel homozygous mutation causes arthrogryposis multiplex congenita

G. Ast, H. Mandel, D. Oz-Levi, 2016, Clinical genetics.

Alternative splicing regulates biogenesis of miRNAs located across exon-intron junctions.

R. Sharan, G. Ast, Asaf Levy, 2013, Molecular cell.

Changes in exon-intron structure during vertebrate evolution affect the splicing pattern of exons.

D. Burstein, Osnat Penn, G. Ast, 2012, Genome research.

Differential GC content between exons and introns establishes distinct strategies of splice-site recognition.

Schraga Schwartz, Tal Pupko, Gil Ast, 2012, Cell reports.

Multifactorial Interplay Controls the Splicing Profile of Alu-Derived Exons

G. Ast, Schraga Schwartz, Oren Ram, 2008, Molecular and Cellular Biology.

Alternative splicing: current perspectives

G. Ast, Amir Goren, E. Kim, 2008, BioEssays : news and reviews in molecular, cellular and developmental biology.

Human-mouse comparative analysis reveals that branch-site plasticity contributes to splicing regulation.

G. Ast, Guy Kol, Galit Lev-Maor, 2005, Human molecular genetics.

Large-scale comparative analysis of splicing signals and their corresponding splicing factors in eukaryotes.

D. Burstein, E. Eyras, G. Ast, 2007, Genome research.

Different levels of alternative splicing among eukaryotes

G. Ast, Alon Magen, E. Kim, 2006, Nucleic acids research.

Quantitative mass spectrometry analysis reveals a panel of nine proteins as diagnostic markers for colon adenocarcinomas

R. Sharan, G. Ast, Sanjeeva Srivastava, 2018, Oncotarget.

The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates

G. Ast, E. Kim, N. Sela, 2010, Genome Biology.

The characteristics, regulation and evolution of human alternatively spliced exons

R. Shamir, R. Sorek, G. Ast, 2006 .

Alu-containing exons are alternatively spliced.

Dan Graur, Rotem Sorek, Gil Ast, 2002, Genome research.

Minimal conditions for exonization of intronic sequences: 5' splice site formation in alu exons.

Dan Graur, Rotem Sorek, Tal Dagan, 2004, Molecular cell.

Alternative splicing and disease

Gil Ast, Eddo Kim, G. Ast, 2008, RNA biology.

The “Alternative” Choice of Constitutive Exons throughout Evolution

Adi Doron-Faigenboim, Tal Pupko, Gil Ast, 2007, PLoS genetics.

Intronic Alus Influence Alternative Splicing

G. Ast, E. Levanon, Oren Ram, 2008, PLoS genetics.

Alternative splicing of Alu exons—two arms are better than one

G. Ast, Schraga Schwartz, Nurit Gal-Mark, 2008, Nucleic acids research.

Alternative approach to a heavy weight problem.

Nadav Ahituv, Gil Ast, Eddo Kim, 2008, Genome research.

The Pivotal Roles of TIA Proteins in 5′ Splice-Site Selection of Alu Exons and Across Evolution

E. Eyras, G. Ast, Schraga Schwartz, 2009, PLoS genetics.

Chromatin density and splicing destiny: on the cross‐talk between chromatin structure and splicing

Schraga Schwartz, Gil Ast, G. Ast, 2010, The EMBO journal.

A network-based analysis of colon cancer splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1

R. Sharan, G. Ast, Schraga Schwartz, 2016, Genome research.

Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB

Schraga Schwartz, Tyson A. Clark, Gil Ast, 2010, Nature Structural &Molecular Biology.

Insights into the connection between cancer and alternative splicing.

Gil Ast, Eddo Kim, G. Ast, 2008, Trends in genetics : TIG.

How did alternative splicing evolve?

Gil Ast, G. Ast, 2004, Nature Reviews Genetics.

The Birth of an Alternatively Spliced Exon: 3' Splice-Site Selection in Alu Exons

Noam Shomron, Rotem Sorek, Gil Ast, 2003, Science.

Characteristics of Transposable Element Exonization within Human and Mouse

Agnes Hotz-Wagenblatt, Britta Mersch, Gil Ast, 2010, PloS one.

the splicing pattern of exons intron structure during vertebrate evolution affect − Changes in exon Material

D. Burstein, Osnat Penn, G. Ast, 2011 .

How Are Short Exons Flanked by Long Introns Defined and Committed to Splicing?

A. Kornblihtt, G. Ast, Galit Lev-Maor, 2016, Trends in genetics : TIG.

SF3B1 association with chromatin determines splicing outcomes.

G. Ast, Galit Lev-Maor, E. Meshorer, 2015, Cell reports.

SF 3 B 1 Association with C hromatin Determines Splicing Outcomes Graphical

G. Ast, Galit Lev-Maor, E. Meshorer, 2022 .

Large-scale discovery of insertion hotspots and preferential integration sites of human transposed elements

G. Ast, Schraga Schwartz, Asaf Levy, 2009, Nucleic acids research.

Boric acid reversibly inhibits the second step of pre‐mRNA splicing

G. Ast, N. Shomron, 2003, FEBS letters.

Splicing components are excluded from the transcriptionally inactive XY body in male meiotic nuclei.

G. Ast, R. Sperling, J. Sperling, 1994, Molecular biology of the cell.

Food-seeking behavior is triggered by skin ultraviolet exposure in males

G. Ast, P. Pfluger, Carmit Levy, 2022, Nature Metabolism.

SERpredict: Detection of tissue- or tumor-specific isoforms generated through exonization of transposable elements

G. Ast, S. Suhai, B. Mersch, 2007, BMC Genetics.

TEs or not TEs? That is the evolutionary question

G. Ast, Amir Goren, Keren Vaknin, 2009, Journal of biology.

Transposable element sequences provide new exons for host genes

G. Ast, Amir Goren, Keren Vaknin, 2009 .

IKAP/Elp1 involvement in cytoskeleton regulation and implication for familial dysautonomia.

G. Ast, A. Razin, M. Weil, 2011, Human molecular genetics.

Phosphatidylserine Increases IKBKAP Levels in Familial Dysautonomia Cells

D. Zeevi, G. Ast, T. Pupko, 2010, PloS one.

Bioactivation of carbamate-based 20(S)-camptothecin prodrugs.

G. Ast, N. Shomron, N. Pessah, 2004, Bioorganic & medicinal chemistry.

A U1/U4/U5 snRNP Complex Induced by a 2′-O-Methyl-Oligoribonucleotide Complementary to U5 snRNA

A. Weiner, G. Ast, 1996, Science.

A novel splicing factor is an integral component of 200S large nuclear ribonucleoprotein (InRNP) particles.

G. Ast, R. Sperling, J. Sperling, 1991, EMBO Journal.

Histone H1.5 binds over splice sites in chromatin and regulates alternative splicing

G. Ast, Ohad Glaich, Yodfat Leader, 2019, Nucleic acids research.

Testing for Natural Selection in Human Exonic Splicing Regulators Associated with Evolutionary Rate Shifts

G. Ast, S. Gelfman, D. Meyer, 2013, Journal of Molecular Evolution.

Calpain 12 Function Revealed through the Study of an Atypical Case of Autosomal Recessive Congenital Ichthyosis.

O. Sarig, G. Ast, N. Shomron, 2016, The Journal of investigative dermatology.

Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome

Agnes Hotz-Wagenblatt, Britta Mersch, Gil Ast, 2007, Genome Biology.

Gene architecture directs splicing outcome in separate nuclear spatial regions.

Erez Lieberman Aiden, R. Sharan, R. Elkon, 2022, Molecular cell.

The importance of DNA methylation of exons on alternative splicing

G. Ast, Ronna Shayevitch, I. Keydar, 2018, RNA.

Genetics of hearing loss in the Arab population of Northern Israel

T. Walsh, M. King, G. Ast, 2018, European Journal of Human Genetics.

The Emergence of Alternative 3′ and 5′ Splice Site Exons from Constitutive Exons

Gil Ast, Eli Koren, Galit Lev-Maor, 2007, PLoS Comput. Biol..

HP 1 Is Involved in Regulat ing the Global Impact of DNA Methylation on Alternative Splicing Graphical

G. Ast, K. Rippe, E. Meshorer, 2015 .

Alternative approach to a heavy weight problem data

G. Ast, N. Ahituv, Amir Goren, 2007 .

Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate

G. Ast, M. Oren, Dror Hollander, 2014, Genome research.

coupled with RNA polymerase II elongation rate Cotranscriptional histone H 2 B monoubiquitylation is tightly Material Supplemental

G. Ast, M. Oren, Dror Hollander, 2014 .

coupled with RNA polymerase II elongation rate Co-transcriptional histone H 2 B monoubiquitylation is tightly

G. Ast, M. Oren, Dror Hollander, 2014 .

Detection and Removal of Biases in the Analysis of Next-Generation Sequencing Reads

Schraga Schwartz, Gil Ast, G. Ast, 2011, PloS one.

SR proteins: a foot on the exon before the transition from intron to exon definition.

G. Ast, Oren Ram, 2007, Trends in genetics : TIG.

Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model.

D. Zeevi, G. Ast, Maya Donyo, 2013, Human molecular genetics.

Combinatorial treatment increases IKAP levels in human cells generated from Familial Dysautonomia patients

G. Ast, Maya Donyo, Sivan Yannai, 2019, bioRxiv.

Pre-mRNA splicing is a determinant of nucleosome organization

Hadas Keren-Shaul, G. Ast, Galit Lev-Maor, 2013, Epigenetics & Chromatin.

Pre-mRNA Splicing Is a Determinant of Nucleosome Organization

Hadas Keren-Shaul, G. Ast, Galit Lev-Maor, 2013, Epigenetics & Chromatin.

The upstream 5′ splice site remains associated to the transcription machinery during intron synthesis

G. Ast, E. Meshorer, Yodfat Leader, 2021, Nature Communications.

Comparative analysis detects dependencies among the 5' splice-site positions.

Gil Ast, Saar Tal, G. Ast, 2004, RNA.

The U1 snRNP Base Pairs with the 5′ Splice Site within a Penta-snRNP Complex

G. Ast, N. Shomron, Hadar Malca, 2003, Molecular and Cellular Biology.

The U1 snRNP Base Pairs with the 5 (cid:2) Splice Site within a Penta-snRNP Complex

G. Ast, N. Shomron, Hadar Malca, 2003 .

Sequences upstream of the branch site are required to form helix II between U2 and U6 snRNA in a trans-splicing reaction.

A. Weiner, G. Ast, T. Pavelitz, 2001, Nucleic acids research.

TranspoGene and microTranspoGene: transposed elements influence on the transcriptome of seven vertebrates and invertebrates

Asaf Levy, Gil Ast, Noa Sela, 2007, Nucleic Acids Res..

Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus.

G. Ast, N. Shomron, Mika Reznik, 2004, Molecular biology of the cell.

Antisense oligonucleotide binding to U5 snRNP induces a conformational change that exposes the conserved loop of U5 snRNA.

A. Weiner, G. Ast, 1997, Nucleic acids research.

RNA-editing-mediated exon evolution

Eli Eisenberg, Rotem Sorek, Gil Ast, 2007, Genome Biology.

kinase localization of a novel catalytic subunit of casein Translated Alu sequence determines nuclear

Dan Graur, Rotem Sorek, Tal Dagan, 2002 .

Alu Exonization Events Reveal Features Required for Precise Recognition of Exons by the Splicing Machinery

Schraga Schwartz, Gil Ast, Ram Oren, 2009, PLoS Comput. Biol..

Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing

G. Ast, N. Shomron, Mika Reznik, 2005, Journal of Cell Science.

Overlapping splicing regulatory motifs—combinatorial effects on splicing

Gil Ast, Eddo Kim, G. Ast, 2010, Nucleic acids research.

SROOGLE: webserver for integrative, user-friendly visualization of splicing signals

Schraga Schwartz, Gil Ast, Eitan Hall, 2009, Nucleic Acids Res..

Bi-allelic variants in neuronal cell adhesion molecule cause a neurodevelopmental disorder characterized by developmental delay, hypotonia, neuropathy/spasticity.

J. Gécz, G. Ast, F. Glaser, 2022, American journal of human genetics.

Biased exonization of transposed elements in duplicated genes: A lesson from the TIF-IA gene

G. Ast, N. Shomron, Maayan Amit, 2007, BMC Molecular Biology.

Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing.

G. Ast, N. Shomron, A. Sharrocks, 2007, RNA.

The importance of being divisible by three in alternative splicing

Gil Ast, G. Ast, Alon Magen, 2005, Nucleic acids research.

A non-EST-based method for exon-skipping prediction.

Ron Shamir, Rotem Sorek, Gil Ast, 2004, Genome research.

IKAP/hELP1 deficiency in the cerebrum of familial dysautonomia patients results in down regulation of genes involved in oligodendrocyte differentiation and in myelination.

G. Ast, A. Razin, D. Cheishvili, 2007, Human molecular genetics.

When epigenetics meets alternative splicing: the roles of DNA methylation and GC architecture.

G. Ast, S. Gelfman, 2013, Epigenomics.

Reversible inhibition of the second step of splicing suggests a possible role of zinc in the second step of splicing.

G. Ast, N. Shomron, Ida Vig, 2002, Nucleic acids research.

Transduplication resulted in the incorporation of two protein-coding sequences into the Turmoil-1 transposable element of C. elegans

G. Ast, T. Pupko, W. Makałowski, 2008, Biology Direct.

Phosphatidylserine enhances IKBKAP transcription by activating the MAPK/ERK signaling pathway.

G. Ast, Maya Donyo, Dror Hollander, 2016, Human molecular genetics.

Drug-targeting strategies for prostate cancer.

G. Ast, 2003, Current pharmaceutical design.

ATM signaling delays skin pigmentation upon UV exposure by mediating MITF function towards DNA repair mode.

R. Elkon, Y. Shiloh, G. Ast, 2023, The Journal of investigative dermatology.

Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia

G. Ast, Maya Donyo, Sivan Yannai, 2016, PLoS genetics.

Phosphatidylserine improves axonal transport by inhibition of HDAC and has potential in treatment of neurodegenerative diseases

G. Ast, Shiran Naftelberg, E. Perlson, 2017, Neural regeneration research.

Genetics of hearing loss in the Arab population of Northern Israel

T. Walsh, M. King, G. Ast, 2018, European Journal of Human Genetics.

Genetics of hearing loss in the Arab population of Northern Israel

T. Walsh, M. King, G. Ast, 2018, European Journal of Human Genetics.

Calpain 12 Function Revealed through the Study of an Atypical Case of Autosomal Recessive Congenital Ichthyosis.

O. Sarig, G. Ast, N. Shomron, 2016, The Journal of investigative dermatology.

Chromatin density and splicing destiny: on the cross‐talk between chromatin structure and splicing

G. Ast, Schraga Schwartz, 2010, The EMBO journal.

Embo Member's Review Chromatin Density and Splicing Destiny: on the Cross-talk between Chromatin Structure and Splicing

G. Ast, Schraga Schwartz, 2022 .

The alternative genome.

Gil Ast, G. Ast, 2005, Scientific American.

A novel U1/U5 interaction indicates proximity between U1 and U5 snRNAs during an early step of mRNA splicing.

A. Weiner, G. Ast, 1997, RNA.

Human histone H1 variants impact splicing outcome by controlling RNA polymerase II elongation.

G. Ast, Galit Lev-Maor, E. Meshorer, 2023, Molecular cell.