P. Lum

发表

Discovering Modes of Action for Therapeutic Compounds Using a Genome-Wide Screen of Yeast Heterozygotes

J. C. Hinshaw, C. J. Roberts, D. Shoemaker, 2004, Cell.

Integrative genomics and drug development.

E. Schadt, P. Lum, J. Derry, 2009, Pharmacogenomics.

Variations in DNA elucidate molecular networks that cause disease

S. Horvath, Bin Zhang, Chunsheng Zhang, 2008, Nature.

An integrative genomics approach to infer causal associations between gene expression and disease

J. Castle, Chunsheng Zhang, J. Lamb, 2005, Nature Genetics.

Mapping the Genetic Architecture of Gene Expression in Human Liver

John D. Storey, K. Hao, A. Kasarskis, 2008, PLoS biology.

Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders. Reverse engineering gene networks to identify key drivers of complex disease phenotypes Published, JLR Papers in Press, October 1, 2006.

E. Schadt, P. Lum, 2006, Journal of Lipid Research.

Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes

J. Lamb, E. Schadt, Jun Zhu, 2006, Journal of neurochemistry.

Integrative Analysis of a Cross-Loci Regulation Network Identifies App as a Gene Regulating Insulin Secretion from Pancreatic Islets

B. Yandell, Chunsheng Zhang, E. Schadt, 2012, PLoS genetics.

The topology of politics : voting connectivity in the US House of Representatives

G. Carlsson, T. Ishkhanov, P. Lum, 2012, NIPS 2012.

expression from a morbidly obese cohort A survey of the genetics of stomach , liver , and adipose gene Material Supplemental

Bin Zhang, Radu Dobrin, C. Suver, 2011 .

Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.

Xia Yang, Eric E Schadt, Andrew Kasarskis, 2010, Genome research.

Validation of Candidate Causal Genes for Abdominal Obesity Which Affect Shared Metabolic Pathways and Networks

Xia Yang, Eric E. Schadt, Joshua L. Deignan, 2009, Nature Genetics.

Diurnal variation of the human adipose transcriptome and the link to metabolic disease

Xia Yang, Hongyue Dai, Yudong D. He, 2009, BMC Medical Genomics.

Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury

Adam R Ferguson, G. Manley, Gunnar E Carlsson, 2015, Nature Communications.

Foetal and neonatal development of cytochrome P-450 and cytochrome P-448 catalysed mixed function oxidases in the rat: induction by 3-methylcholanthrene.

C. Ioannides, P. Lum, S. Walker, 1985, Toxicology.

Development of an approach for ab initio estimation of compound-induced liver injury based on global gene transcriptional profiles.

Yudong D. He, J. Waring, R. Ulrich, 2006, Genome informatics. International Conference on Genome Informatics.

DiOC6 staining reveals organelle structure and dynamics in living yeast cells.

P. Lum, A. Koning, R. Wright, 1993, Cell motility and the cytoskeleton.

Degradation of HMG-CoA reductase-induced membranes in the fission yeast, Schizosaccharomyces pombe

P. Lum, R. Wright, Robin Wright, 1995, The Journal of cell biology.

Erratum: Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene (American Society for Clinical Investigation (2015)125:4 (1739-1751) DOI 10.1172/JCI74692)

T. Assimes, P. Tsao, J. Pankow, 2016 .

Computational approaches to drug target identification

P. Lum, Thomas B. Freeman, 2016 .

enzyme activities in human liver Systematic genetic and genomic analysis of cytochrome P 450 Material

K. Hao, A. Kasarskis, R. Ulrich, 2010 .

Novel Transcriptome Profiling Analyses Demonstrate that Selective PPAR γ Modulators Display Attenuated and Selective Gene Regulatory Activity in Comparison with PPAR γ Full Agonists

P. Lum, Kenny K. Wong, J. Berger, 2012 .

Induction of cytochrome P-448 activity as exemplified by the O-deethylation of ethoxyresorufin. Effects of dose, sex, tissue and animal species.

C. Ioannides, D. Parke, P. Lum, 1986, Biochemical pharmacology.

Cytochrome P-448 and the activation of toxic chemicals and carcinogens.

C. Ioannides, D. Parke, P. Lum, 1984, Xenobiotica; the fate of foreign compounds in biological systems.

Alkoxyresorufin O-dealkylases: association with the murine Ah locus.

C. Ioannides, P. Lum, R. Mayer, 1986, Cancer letters.

Determination of cytochrome P-448 activity in biological tissues.

C. Ioannides, D. Parke, P. Lum, 1984, The Biochemical journal.

Molecular requirements of the human nucleoside transporters hCNT1, hCNT2, and hENT1.

P. Lum, P. Swaan, J. Unadkat, 2004, Molecular pharmacology.

Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronaviruses

P. Lum, B. Louie, Xiaoying Koh, 2022, bioRxiv.

Functional Discovery via a Compendium of Expression Profiles

Yudong D. He, T. Hughes, C. J. Roberts, 2000, Cell.

vasculatureproinflammatory gene expression in the -HSD1 inhibition reduces atherosclerosis in mice by

Jun Zhu, P. Lum, Xia Yang, 2015 .

11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature.

Jun Zhu, P. Lum, Xia Yang, 2013, Physiological genomics.

Corrigendum to Common body mass index-associated variants confer risk of extreme obesity [Human Molecular Genetics, 2009; 18;18, 3502-3507, 10.1093/hmg/ddp292]

M. Daly, J. Hirschhorn, B. Neale, 2010 .

Common body mass index-associated variants confer risk of extreme obesity.

M. Daly, J. Hirschhorn, B. Neale, 2009, Human molecular genetics.

A single glycine mutation in the equilibrative nucleoside transporter gene, hENT1, alters nucleoside transport activity and sensitivity to nitrobenzylthioinosine.

P. Lum, D. Sengupta, Y. Lai, 2002, Biochemistry.

Human intestinal es nucleoside transporter: molecular characterization and nucleoside inhibitory profiles

P. Lum, J. Unadkat, L. Y. Ngo, 2000, Cancer Chemotherapy and Pharmacology.

Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles.

R G Ulrich, J. Waring, R. Ulrich, 2001, Toxicology and applied pharmacology.

An eQTL biological data visualization challenge and approaches from the visualization community

Kay Nieselt, Ryo Sakai, William C. Ray, 2012, BMC Bioinformatics.

Increasing the Power to Detect Causal Associations by Combining Genotypic and Expression Data in Segregating Populations

Jun Zhu, Matthew C. Wiener, Eric E. Schadt, 2007, PLoS Comput. Biol..

Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels.

Eric E Schadt, Jun Zhu, Sonia Carlson, 2005, Genomics.

Identification and validation of genes affecting aortic lesions in mice.

Joshua L. Deignan, E. Schadt, Jun Zhu, 2010, The Journal of clinical investigation.

Liver and Adipose Expression Associated SNPs Are Enriched for Association to Type 2 Diabetes

Xia Yang, Eric E. Schadt, Lee M. Kaplan, 2010, PLoS genetics.

Genomics and cardiovascular drug development.

Pek Yee Lum, P. Lum, A. Plump, 2009, Journal of the American College of Cardiology.

Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits

E E Schadt, J. Lamb, E. Schadt, 2005, Nature Genetics.

An integrative genomics approach to the reconstruction of gene networks in segregating populations

J. Zhu, J. Thompson, J. Lamb, 2004, Cytogenetic and Genome Research.

Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms

Borislav D. Dimitrov, Tanya Petrossian, Stephan D. Gadola, 2015, The Journal of allergy and clinical immunology.

Extracting insights from the shape of complex data using topology

P. Y. Lum, G. Singh, A. Lehman, 2013, Scientific Reports.

Gene expression profiling of rat liver reveals a mechanistic basis for ritonavir-induced hyperlipidemia.

Xudong Dai, Yudong D. He, Guy Cavet, 2007, Genomics.

From drug to protein: using yeast genetics for high-throughput target discovery.

P. Lum, C. Armour, 2005, Current opinion in chemical biology.

Experimental annotation of the human genome using microarray technology

R. Stoughton, G. Schimmack, Lani F. Wu, 2001, Nature.

Novel Transcriptome Profiling Analyses Demonstrate that Selective Peroxisome Proliferator-Activated Receptor γ (PPARγ) Modulators Display Attenuated and Selective Gene Regulatory Activity in Comparison with PPARγ Full Agonists

H. Dai, P. Lum, Kenny K. Wong, 2012, Molecular Pharmacology.

Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice

B. Yandell, E. Schadt, M. Cleary, 2009, Mammalian Genome.

The molecular and metabolic essentials for long-distance flight in insects

P. Lum, H. Chino, E. Nagao, 1992, Journal of Comparative Physiology B.

Development of the Digital Arthritis Index, a Novel Metric to Measure Disease Parameters in a Rat Model of Rheumatoid Arthritis

P. Lum, L. Schaevitz, Brenton Louie, 2017, Front. Pharmacol..

Trehalose, the insect blood sugar, inhibits loading of diacylglycerol by lipophorin from the fat body in locusts.

P. Lum, H. Chino, 1990, Biochemical and biophysical research communications.

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.

T. Assimes, P. Tsao, J. Pankow, 2016, The Journal of clinical investigation.

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene

T. Assimes, P. Tsao, J. Pankow, 2015 .

A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort.

Bin Zhang, Radu Dobrin, C. Suver, 2011, Genome research.

Acridine Derivatives as Inhibitors of the IRE1α–XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma

P. Lum, A. Koong, A. Giaccia, 2016, Molecular Cancer Therapeutics.

Uncovering precision phenotype-biomarker associations in traumatic brain injury using topological data analysis

Pratik Mukherjee, Adam R Ferguson, Jesse Paquette, 2017, PloS one.

Parallel analysis of tagged deletion mutants efficiently identifies genes involved in endoplasmic reticulum biogenesis

M. Parrish, D. Shoemaker, P. Garrett-engele, 2003, Yeast.

Meditation and vacation effects have an impact on disease-associated molecular phenotypes

E. Schadt, E. Epel, E. Blackburn, 2016, Translational Psychiatry.

Molecular, functional and evolutionary characterization of the gene encoding HMG‐CoA reductase in the fission yeast, Schizosaccharomyces pombe

P. Lum, R. Wright, Scott Edwards, 1996, Yeast.

Primary role of adipokinetic hormone in the formation of low density lipophorin in locusts.

P. Lum, H. Chino, 1990, Journal of lipid research.

The Use of a Compendium of Expression Profiles for Mechanism of Toxicity Predictions

J. Waring, R. Ulrich, C. J. Roberts, 2005 .

A Short Introduction to the Expression Profile Toolbox

Jeffrey F. Waring, Xudong Dai, Yudong He, 2005 .

Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits

Eric E. Schadt, Aldons J. Lusis, Pek Yee Lum, 2005 .

Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data

Borislav Dimitrov, Peter Howarth, Tanya Petrossian, 2015, The Lancet.

Microarray of 16S rRNA Gene Probes Across Microbiome Samples

Alexander J. Probst, P. Lum, G. Andersen, 2014 .

Molecular, functional and evolutionary characterization of the gene encoding HMG‐CoA reductase in the fission yeast, Schizosaccharomyces pombe

P. Lum, R. Wright, S. Edwards, 1996, Yeast.

Preserving yeast colonies grown on agar plates as a dry, thin sheet.

P. Lum, R. Wright, 1995, BioTechniques.

Topological data analysis of Escherichia coli O157:H7 and non-O157 survival in soils

David E. Crowley, Jincai Ma, Pek Y. Lum, 2014, Front. Cell. Infect. Microbiol..

Diurnal variation of the human adipose transcriptome and the link to metabolic disease

Chunsheng Zhang, J. Lamb, E. Schadt, 2009 .

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.

T. Assimes, J. Pankow, K. Hao, 2015, The Journal of clinical investigation.

11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature.

Jun Zhu, P. Lum, Xia Yang, 2013, Physiological genomics.

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.

T. Assimes, P. Tsao, J. Pankow, 2016, The Journal of clinical investigation.

Diurnal variation of the human adipose transcriptome and the link to metabolic disease

Chunsheng Zhang, J. Lamb, E. Schadt, 2009, BMC Medical Genomics.

Acridine Derivatives as Inhibitors of the IRE1α–XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma

P. Lum, A. Koong, A. Giaccia, 2016, Molecular Cancer Therapeutics.

Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.

K. Hao, A. Kasarskis, R. Ulrich, 2010, Genome research.

Increasing the Power to Detect Causal Associations among Genes and between Genes and Complex Traits by Combining Genotypic and Gene Expression Data in Segregating Populations

Matthew C. Wiener, Eric E. Schadt, Jun Zhu, 2005 .