F. Totzke

发表

Inverse in silico screening for identification of kinase inhibitor targets.

L. Meijer, S. Zahler, S. Tietze, 2007, Chemistry & biology.

PTK 787 / ZK 222584 , a Novel and Potent Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases , Impairs Vascular Endothelial Growth Factor-induced Responses and Tumor Growth after Oral Administration

Martin R. Schneider, J. Mestan, F. Totzke, 2000 .

Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes.

L. Meijer, F. Totzke, B. Voigt, 2005, Bioorganic & medicinal chemistry letters.

Anthraquinones and betaenone derivatives from the sponge-associated fungus Microsphaeropsis species: novel inhibitors of protein kinases.

F. Totzke, D. Marmé, P. Proksch, 2000, Journal of natural products.

Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.

F. Totzke, M. Kubbutat, P. Proksch, 2009, Journal of natural products.

Optimization of potent DFG-in inhibitors of platelet derived growth factor receptorβ (PDGF-Rβ) guided by water thermodynamics.

F. Totzke, C. Schächtele, D. Cappel, 2015, Journal of medicinal chemistry.

Development of first lead structures for phosphoinositide 3-kinase-C2γ inhibitors.

F. Totzke, M. Kubbutat, S. Laufer, 2015, Journal of medicinal chemistry.

Diversity-oriented synthesis of pochonins and biological evaluation against a panel of kinases.

F. Totzke, S. Barluenga, N. Winssinger, 2006, Chemistry.

A Novel Roscovitine Derivative Potently Induces G1-Phase Arrest in Platelet-Derived Growth Factor-BB-Activated Vascular Smooth Muscle Cells

F. Totzke, M. Kubbutat, E. Heiss, 2010, Molecular Pharmacology.

Novel aspects in structure–activity relationships of profiled 1-aza-9-oxafluorenes as inhibitors of Alzheimer's disease-relevant kinases cdk1, cdk5 and gsk3β

F. Totzke, W. Sippl, K. Wichapong, 2012 .

Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases.

F. Totzke, C. Schächtele, A. Hilgeroth, 2012, Bioorganic & medicinal chemistry letters.

Novel CDK Inhibition Profiles of Structurally Varied 1-Aza-9-oxafluorenes.

L. Meijer, F. Totzke, B. Voigt, 2005 .

Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors.

F. Totzke, W. Sippl, C. Schächtele, 2010, Bioorganic & medicinal chemistry letters.

Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors.

F. Totzke, M. Kubbutat, S. Laufer, 2014, European journal of medicinal chemistry.

Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells

F. Totzke, M. Kubbutat, Y. Lou, 2013, The Journal of pharmacy and pharmacology.

2-Anilino-4-(benzimidazol-2-yl)pyrimidines--a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines.

Peter G. Jones, F. Totzke, M. Kubbutat, 2012, European journal of medicinal chemistry.

Decalactone Derivatives from Corynespora cassiicola, an Endophytic Fungus of the Mangrove Plant Laguncularia racemosa

F. Totzke, M. Kubbutat, P. Proksch, 2012 .

Cytotoxic effects of the anthraquinone derivatives 1′-deoxyrhodoptilometrin and (S)-(−)-rhodoptilometrin isolated from the marine echinoderm Comanthus sp.

F. Totzke, M. Kubbutat, P. Proksch, 2016, Archives of Toxicology.

Inducible expression of human phospholipase C-gamma 2 and its activation by platelet-derived growth factor B-chain homodimer and platelet-derived growth factor A-chain homodimer in transfected NIH 3T3 fibroblasts.

F. Totzke, H. Hug, D. Marmé, 1992, European journal of biochemistry.

Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.

F. Totzke, M. Kubbutat, P. Proksch, 2011, Bioorganic & medicinal chemistry.

New 3,4-bis(indol-1-yl)maleimides as protein kinase inhibitors

F. Totzke, M. Kubbutat, L. Dezhenkova, 2019, Chemistry of Heterocyclic Compounds.

7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a “Cut and Glue” Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors

S. Knapp, F. Totzke, M. Kubbutat, 2021, Molecules.

Dual IGF-1R/SRC inhibitors based on a N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure.

F. Totzke, M. Kubbutat, C. Kunick, 2011, European journal of medicinal chemistry.

Novel Protein Kinase Inhibitors Related to Tau Pathology Modulate Tau Protein-Self Interaction Using a Luciferase Complementation Assay

F. Totzke, W. Sippl, C. Schächtele, 2018, Molecules.

Discovery of dually acting small-molecule inhibitors of cancer-resistance relevant receptor tyrosine kinases EGFR and IGF-1R

F. Totzke, W. Sippl, C. Schächtele, 2016 .

Identification of 2-anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as dual PLK1/VEGF-R2 kinase inhibitor chemotypes by structure-based lead generation.

F. Totzke, M. Kubbutat, K. Baumann, 2010, Journal of medicinal chemistry.

Novel indeno[1,2-b]indoloquinones as inhibitors of the human protein kinase CK2 with antiproliferative activity towards a broad panel of cancer cell lines.

F. Totzke, C. Götz, P. Bednarski, 2012, Biochemical and biophysical research communications.

Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.

F. Totzke, C. Götz, P. Bednarski, 2012, Bioorganic & medicinal chemistry.

Tri- and tetrasubstituted pyrazole derivates: regioisomerism switches activity from p38MAP kinase to important cancer kinases.

Pierre Koch, Bassam Abu Thaher, Christoph Schächtele, 2012, Journal of Medicinal Chemistry.

Matrix compare analysis discriminates subtle structural differences in a family of novel antiproliferative agents, diaryl-3-hydroxy-2,3,3a,10a-tetrahydrobenzo[b]cycylopenta[e]azepine-4,10(1H,5H)-diones.

F. Totzke, M. Kubbutat, A. Link, 2006, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of novel 3-aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as vascular endothelial growth factor receptor (VEGF-R) inhibitors.

Stefan Laufer, Dieter Schollmeyer, Christian Peifer, 2008, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors.

G. Klebe, R. Brenk, F. Totzke, 2006, Journal of medicinal chemistry.

Modular synthesis of radicicol A and related resorcylic acid lactones, potent kinase inhibitors.

F. Totzke, S. Barluenga, N. Winssinger, 2007, Angewandte Chemie.

N-substituted 2'-(aminoaryl)benzothiazoles as kinase inhibitors: hit identification and scaffold hopping.

F. Totzke, M. Kubbutat, C. Schächtele, 2009, Bioorganic & medicinal chemistry letters.

Substituted 2-arylbenzothiazoles as kinase inhibitors: hit-to-lead optimization.

F. Totzke, M. Kubbutat, C. Schächtele, 2009, Bioorganic & medicinal chemistry.

Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense.

F. Totzke, M. Kubbutat, P. Proksch, 2008, Journal of natural products.

Synthesis and Structure of FluorescentChelate Boron Complexes of 4-Anilinomethylidene-1-benzazepine-2,5-dioneLigands

F. Totzke, M. Kubbutat, C. Kunick, 2011 .

Over‐expression of protein kinase C‐α enhances platelet‐derived growth factor‐ and phorbol ester‐ but not calcium ionophore‐induced formation of prostaglandins in NIH 3T3 fibroblasts

F. Totzke, D. Marmé, G. Finkenzeller, 1993, FEBS letters.

The Crataegus extract WS 1442 inhibits balloon catheter-induced intimal hyperplasia in the rat carotid artery by directly influencing PDGFR-beta.

S. Zahler, F. Totzke, A. Vollmar, 2010, Atherosclerosis.

9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp.

F. Totzke, P. Proksch, Wenhan Lin, 2011, Bioorganic & medicinal chemistry.

Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation.

F. Totzke, M. Kubbutat, P. Proksch, 2009, Molecular nutrition & food research.

Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors.

F. Totzke, S. Laufer, C. Schächtele, 2009, European journal of medicinal chemistry.

Bioactive pyrrole alkaloids isolated from the Red Sea: marine sponge Stylissa carteri

F. Totzke, M. Kubbutat, P. Proksch, 2018, Zeitschrift fur Naturforschung. C, Journal of biosciences.

Identification of Inhibitors of the Tyrosine Kinase c‐Met by Structure‐Based Virtual Screening

M. Rarey, F. Totzke, M. Kubbutat, 2011, Molecular informatics.

Hydrophobic Derivatives of Glycopeptide Antibiotics as Inhibitors of Protein Kinases

F. Totzke, M. Kubbutat, M. Preobrazhenskaya, 2018, Biochemistry (Moscow).

PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.

J. Mestan, F. Totzke, G. Martiny-Baron, 2000, Cancer research.

Novel inhibitors of breast cancer relevant kinases Brk and HER2

F. Totzke, W. Sippl, C. Schächtele, 2014 .

Discovery of 4-anilino α-carbolines as novel Brk inhibitors.

F. Totzke, W. Sippl, C. Schächtele, 2014, Bioorganic & medicinal chemistry letters.

Discovery of 4‐Benzylamino‐Substituted α‐Carbolines as a Novel Class of Receptor Tyrosine Kinase Inhibitors

Wolfgang Sippl, Martin Krug, Andreas Hilgeroth, 2011, ChemMedChem.

7-Bromoindirubin-3′-oxime induces caspase-independent cell death

L. Meijer, F. Totzke, M. Knockaert, 2006, Oncogene.

Roscovitine Targets, Protein Kinases and Pyridoxal Kinase*[boxs]

Lin Tang, Hervé Galons, Olivier Lozach, 2005, Journal of Biological Chemistry.

Structure‐Aided Optimization of Kinase Inhibitors Derived from Alsterpaullone

Rick Gussio, Laurent Meijer, Conrad Kunick, 2005, Chembiochem : a European journal of chemical biology.

Antitumoral and antiangiogenic efficacy of bisphosphonates in vitro and in a murine RENCA model.

F. Totzke, J. Drevs, I. Merfort, 2008, Anticancer research.

Soluble VEGFR-1 secreted by endothelial cells and monocytes is present in human serum and plasma from healthy donors

F. Totzke, G. Martiny-Baron, D. Marmé, 2004, Angiogenesis.

Mapping of the Sites for Ligand Binding and Receptor Dimerization at the Extracellular Domain of the Vascular Endothelial Growth Factor Receptor FLT-1*

E. Kremmer, F. Totzke, G. Martiny-Baron, 1997, The Journal of Biological Chemistry.

Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and PDGFR-β related to anticancer drug resistance

F. Totzke, W. Sippl, C. Schächtele, 2017, Journal of enzyme inhibition and medicinal chemistry.

Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and IGF-1R

F. Totzke, W. Sippl, C. Schächtele, 2017, Journal of enzyme inhibition and medicinal chemistry.

Scaffold hopping identifies 6,8‐disubstituted purines as novel anaplastic lymphoma kinase inhibitors

F. Totzke, M. Kubbutat, C. Kunick, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Flavopiridol Protects Against Inflammation by Attenuating Leukocyte-Endothelial Interaction via Inhibition of Cyclin-Dependent Kinase 9

S. Zahler, F. Totzke, A. Vollmar, 2011, Arteriosclerosis, Thrombosis and Vascular Biology.

The Drosophila melanogaster l(2)gl gene encodes a protein homologous to the cadherin cell-adhesion molecule family.

F. Totzke, C. Klämbt, O. Schmidt, 1989, Developmental biology.

Probing Novel 1‐Aza‐9‐oxafluorenes as Selective GSK‐3β Inhibitors

F. Totzke, B. Voigt, C. Schächtele, 2008, ChemMedChem.

Marine Derived Hamacanthins as Lead for the Development of Novel PDGFRβ Protein Kinase Inhibitors

F. Totzke, S. Gul, B. Pinchuk, 2013, Marine drugs.

Assessing the target differentiation potential of imidazole-based protein kinase inhibitors.

Jürgen Bajorath, Stefan Laufer, Preeti Iyer, 2012, Journal of medicinal chemistry.

Cell Lines Expressing Recombinant Transmembrane Domain–Activated Receptor Kinases as Tools for Drug Discovery

F. Totzke, M. Kubbutat, H. Weber, 2014, Journal of biomolecular screening.

Search for inhibitors of bacterial and human protein kinases among derivatives of diazepines[1,4] annelated with maleimide and indole cycles.

F. Totzke, M. Kubbutat, M. Preobrazhenskaya, 2008, Journal of medicinal chemistry.

Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones.

F. Totzke, T. Beckers, H. Fiebig, 2012, Bioorganic & medicinal chemistry.

Over‐expression of human phospholipase C‐γ2 enhances platelet‐derived growth factor‐induced mobilization of intracellular Ca2+ and the release of arachidonic acid and prostaglandins in NIH 3T3 fibroblasts

F. Totzke, H. Hug, D. Marmé, 1992, FEBS letters.

Hydrophobic Derivatives of Glycopeptide Antibiotics as Inhibitors of Protein Kinases

F. Totzke, M. Kubbutat, M. Preobrazhenskaya, 2018, Biochemistry (Moscow).

Hexa‐, hepta‐ and nonaprenylhydroquinones isolated from marine sponges Sarcotragus muscarum and Ircinia fasciculata inhibit NF‐k B signalling in H4IIE cells

F. Totzke, M. Kubbutat, P. Proksch, 2009 .

Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors.

F. Totzke, W. Sippl, A. Hilgeroth, 2017, Bioorganic & medicinal chemistry letters.

1-Aryl-4,6-dihydropyrazolo[4,3-d][1]benzazepin-5(1H)-ones: a new class of antiproliferative agents with selectivity for human leukemia and breast cancer cell lines.

F. Totzke, M. Kubbutat, C. Kunick, 2007, European journal of medicinal chemistry.

Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors.

F. Totzke, W. Sippl, A. Hilgeroth, 2010, Bioorganic & medicinal chemistry letters.