Jian Cai

发表

Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: An approach to understand pathological and biochemical alterations in AD

D. Butterfield, R. Sultana, D. Boyd-Kimball, 2006, Neurobiology of Aging.

Proteomics analysis provides insight into caloric restriction mediated oxidation and expression of brain proteins associated with age-related impaired cellular processes: Mitochondrial dysfunction, glutamate dysregulation and impaired protein synthesis

D. Butterfield, H. Poon, Jian Cai, 2006, Neurobiology of Aging.

Lack of p 53 Affects the Expression of Several Brain Mitochondrial Proteins : Insights from Proteomics into Important Pathways Regulated by p 53

D. Butterfield, R. Sultana, Jian Cai, 2017 .

Lack of p53 Affects the Expression of Several Brain Mitochondrial Proteins: Insights from Proteomics into Important Pathways Regulated by p53

D. Butterfield, R. Sultana, Jian Cai, 2012, PloS one.

Expression and characterization of human CB1 cannabinoid receptor in methylotrophic yeast Pichia pastoris.

Jian Cai, W. Pierce, W. Feng, 2005, Protein expression and purification.

Expression of CB2 cannabinoid receptor in Pichia pastoris.

Jian Cai, W. Pierce, W. Feng, 2002, Protein expression and purification.

The wheat germ agglutinin‐fractionated proteome of subjects with Alzheimer's disease and mild cognitive impairment hippocampus and inferior parietal lobule: Implications for disease pathogenesis and progression

D. Butterfield, R. Sultana, Jian Cai, 2010, Journal of neuroscience research.

Plasma and Serum Proteins Bound to Nanoceria: Insights into Pathways by which Nanoceria may Exert Its Beneficial and Deleterious Effects In Vivo

R. Sultana, Jian Cai, W. Pierce, 2020, Journal of nanomedicine & nanotechnology.

Reaching Out to Send a Message: Proteins Associated with Neurite Outgrowth and Neurotransmission are Altered with Age in the Long-Lived Naked Mole-Rat

D. Butterfield, Jian Cai, J. Klein, 2016, Neurochemical Research.

Redox Activation of Aldose Reductase in the Ischemic Heart*

Jian Cai, A. Bhatnagar, Xian-Liang Tang, 2006, Journal of Biological Chemistry.

Redox proteomics analyses of the influence of co-expression of wild-type or mutated LRRK2 and Tau on C. elegans protein expression and oxidative modification: relevance to Parkinson disease.

D. Butterfield, R. Sultana, Jian Cai, 2012, Antioxidants & redox signaling.

NATb/NAT1*4 promotes greater arylamine N‐acetyltransferase 1 mediated DNA adducts and mutations than NATa/NAT1*4 following exposure to 4‐aminobiphenyl

Jian Cai, J. States, M. Doll, 2012, Molecular carcinogenesis.

Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development.

Jian Cai, Shufeng Zhou, Zhi-Wei Zhou, 2009, Current medicinal chemistry.

Plasma bradykinin and early diabetic nephropathy lesions in type 1 diabetes mellitus

R. Vasan, P. Kimmel, B. Rovin, 2017, PloS one.

Sex differences in brain proteomes of neuron‐specific STAT3‐null mice after cerebral ischemia/reperfusion

R. Sultana, Jian Cai, W. Pierce, 2012, Journal of neurochemistry.

Quantitative proteomics analysis of phosphorylated proteins in the hippocampus of Alzheimer disease subjects

D. Butterfield, R. Sultana, Jian Cai, 2011 .

Differential expression of proteins in renal cortex and medulla: a proteomic approach.

Jian Cai, W. Pierce, J. Klein, 2002, Kidney international.

Substrate in Human Neutrophils Myeloid-Related Protein-14 Is a p38 MAPK

Jian Cai, M. Merchant, M. Rane, 2013 .

Jian Cai, M. Merchant, M. Rane, 2005, The Journal of Immunology.

Cytochromes P450 catalyze the reduction of α,β-unsaturated aldehydes.

Jian Cai, F. Guengerich, R. Prough, 2011, Chemical research in toxicology.

Detection of Anthocyanins/Anthocyanidins in Animal Tissues

Jian Cai, F. Aqil, Ramesh C. Gupta, 2014, Journal of agricultural and food chemistry.

Do proteomics analyses provide insights into reduced oxidative stress in the brain of an Alzheimer disease transgenic mouse model with an M631L amyloid precursor protein substitution and thereby the importance of amyloid-beta-resident methionine 35 in Alzheimer disease pathogenesis?

D. Butterfield, R. Sultana, Jian Cai, 2012, Antioxidants & redox signaling.

Differential Expression and Redox Proteomics Analyses of an Alzheimer Disease Transgenic Mouse Model: Effects of the Amyloid-β Peptide of APPΞ

D. Butterfield, R. Sultana, Jian Cai, 2011 .

Metallothionein Disulfides Are Present in Metallothionein-overexpressing Transgenic Mouse Heart and Increase under Conditions of Oxidative Stress*

Jian Cai, W. Pierce, Y. J. Kang, 2006, Journal of Biological Chemistry.

Measurement and identification of S-glutathiolated proteins.

Jian Cai, K. Ramana, S. Srivastava, 2010, Methods in enzymology.

Dietary Carnosine Prevents Early Atherosclerotic Lesion Formation in Apolipoprotein E–Null Mice

Jian Cai, A. Bhatnagar, A. Agarwal, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Modulation of Cytochrome c Oxidase-Va Is Possibly Involved in Metallothionein Protection from Doxorubicin Cardiotoxicity

Jian Cai, J. Klein, Y. J. Kang, 2005, Journal of Pharmacology and Experimental Therapeutics.

Role of Aldose Reductase in the Metabolism and Detoxification of Carnosine-Acrolein Conjugates*

Jian Cai, J. Klein, M. Merchant, 2013, The Journal of Biological Chemistry.

Biochemical and mass spectrometric characterization of the human CB2 cannabinoid receptor expressed in Pichia pastoris--importance of correct processing of the N-terminus.

Jian Cai, W. Pierce, Z. Song, 2007, Protein expression and purification.

Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent

Jian Cai, J. States, M. Doll, 2012, Drug Metabolism and Disposition.

Bone selective effect of an estradiol conjugate with a novel tetracycline-derived bone-targeting agent.

Jian Cai, W. Pierce, N. Smith, 2009, Bioorganic & medicinal chemistry letters.

Metallothionein transfers zinc to mitochondrial aconitase through a direct interaction in mouse hearts.

Jian Cai, W. Pierce, R. Franklin, 2005, Biochemical and biophysical research communications.

uPAR isoform 2 forms a dimer and induces severe kidney disease in mice.

Jian Cai, J. Klein, M. Merchant, 2019, The Journal of clinical investigation.

The role of charge in the toxicity of polymer-coated cerium oxide nanomaterials to Caenorhabditis elegans.

D. Butterfield, Jian Cai, J. Klein, 2017, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

Quantitative expression proteomics and phosphoproteomics profile of brain from PINK1 knockout mice: insights into mechanisms of familial Parkinson's disease

D. Butterfield, R. Sultana, Jian Cai, 2015, Journal of neurochemistry.

2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-α release: implications for the reactive oxygen species-mediated mechanisms of chemobrain.

D. Butterfield, R. Sultana, Jian Cai, 2011, Free radical biology & medicine.

An increase in S‐glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approach

D. Butterfield, R. Sultana, Jian Cai, 2007, Journal of neuroscience research.

Disulfide Bonds of GM2 Synthase Homodimers

Jian Cai, W. Pierce, D. Darling, 2000, The Journal of Biological Chemistry.

Neurodegenerative and inflammatory pathway components linked to TNF-α/TNFR1 signaling in the glaucomatous human retina.

Jian Cai, Xiangjun Yang, G. Tezel, 2011, Investigative ophthalmology & visual science.

Acrylonitrile irreversibly inactivates glyceraldehyde-3-phosphate dehydrogenase by alkylating the catalytically active cysteine 149.

Jian Cai, F. Benz, E. Campian, 2002, Chemico-biological interactions.

PROTEOMIC AND UTR ANALYSES OF A RAPIDLY EVOLVING HYPERVARIABLE FAMILY OF VERTEBRATE PHEROMONES

L. Houck, Jian Cai, D. Wilburn, 2012, Evolution; international journal of organic evolution.

Scalable Purification and Characterization of the Anticancer Lunasin Peptide from Soybean

Jian Cai, K. Davis, S. Hume, 2012, PloS one.

Sustained systemic delivery of green tea polyphenols by polymeric implants significantly diminishes benzo[a]pyrene-induced DNA adducts.

Jian Cai, Ramesh C. Gupta, M. Vadhanam, 2011, Chemical research in toxicology.

Redox proteomics analysis of brains from subjects with amnestic mild cognitive impairment compared to brains from subjects with preclinical Alzheimer's disease: insights into memory loss in MCI.

D. Butterfield, Jian Cai, W. Pierce, 2011, Journal of Alzheimer's disease : JAD.

Protein modification by acrolein: formation and stability of cysteine adducts.

Jian Cai, W. Pierce, A. Bhatnagar, 2009, Chemical research in toxicology.

D. Butterfield, Jian Cai, J. Klein, 2015, Biochimica et biophysica acta.

Bioactivation and Protein Modification Reactions of Unsaturated Aldehydes

Jian Cai, W. Pierce, A. Bhatnagar, 2008 .

Fluoride Exposure Attenuates Expression of Streptococcus pyogenes Virulence Factors*

Jian Cai, W. Pierce, J. Klein, 2002, The Journal of Biological Chemistry.

Involvement of stat3 in mouse brain development and sexual dimorphism: A proteomics approach

D. Butterfield, R. Sultana, Jian Cai, 2010, Brain Research.

Mechanisms of acrolein-induced myocardial dysfunction: implications for environmental and endogenous aldehyde exposure.

Yan Gu, Aruni Bhatnagar, Jian Cai, 2007, American journal of physiology. Heart and circulatory physiology.

An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach.

D. Butterfield, R. Sultana, Jian Cai, 2014, Free radical biology & medicine.

Cytochromes P450 catalyze oxidation of α,β-unsaturated aldehydes

Jian Cai, W. Pierce, F. Guengerich, 2007 .

Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Aβ(1–42): Implications for Alzheimer's disease

D. Butterfield, D. Boyd-Kimball, H. Poon, 2006, Neurobiology of Aging.

Original Contribution

D. Butterfield, R. Sultana, Jian Cai, 2022 .

Poly-ubiquitin profile in Alzheimer disease brain

D. Butterfield, Jian Cai, J. Klein, 2018, Neurobiology of Disease.

Proteomic analysis of CA1 and CA3 regions of rat hippocampus and differential susceptibility to intermittent hypoxia

Jian Cai, W. Pierce, J. Klein, 2002, Journal of neurochemistry.

Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age.

Jian Cai, D. Butterfield, R. Sultana, 2011, Journal of proteomics.

Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach

D. Butterfield, R. Sultana, H. Poon, 2006, Neurobiology of Disease.

Catalytic reduction of carbonyl groups in oxidized PAPC by Kvβ2 (AKR6).

Jian Cai, A. Bhatnagar, O. Barski, 2011, Chemico-Biological Interactions.

Immunoproteomic analysis of potential serum biomarker candidates in human glaucoma.

R. Ritch, Jian Cai, J. Liebmann, 2012, Investigative ophthalmology & visual science.

Preclinical Alzheimer disease: Brain oxidative stress, Aβ peptide and proteomics

D. Butterfield, Jian Cai, W. Pierce, 2010, Neurobiology of Disease.

Involvement of the 90-kDa Heat Shock Protein (Hsp-90) in CB2 Cannabinoid Receptor-Mediated Cell Migration: A New Role of Hsp-90 in Migration Signaling of a G Protein-Coupled Receptor

Jian Cai, W. Pierce, Z. Song, 2007, Molecular Pharmacology.

Mass Spectrometry Analysis of Human CB2 Cannabinoid Receptor and Its Associated Proteins.

Jian Cai, Z. Song, A. Laun, 2017, Methods in enzymology.

Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function.

R. de Cabo, D. Butterfield, Jian Cai, 2017, The Journal of nutritional biochemistry.

An astrocyte-specific proteomic approach to inflammatory responses in experimental rat glaucoma.

Jian Cai, Xiangjun Yang, G. Tezel, 2012, Investigative ophthalmology & visual science.

Quantitative phosphoproteomic analyses of the inferior parietal lobule from three different pathological stages of Alzheimer's disease.

Jian Cai, D. Butterfield, Jian Cai, 2015, Journal of Alzheimer's disease : JAD.

Doxorubicin-induced thymus senescence.

D. Butterfield, R. Sultana, Jian Cai, 2010, Journal of proteome research.

Effect of green tea catechins and hydrolyzable tannins on benzo[a]pyrene-induced DNA adducts and structure-activity relationship.

Jian Cai, Ramesh C. Gupta, Pengxiao Cao, 2010, Chemical research in toxicology.

Lymphocyte mitochondria: toward identification of peripheral biomarkers in the progression of Alzheimer disease.

D. Butterfield, P. Mecocci, R. Sultana, 2013, Free radical biology & medicine.

Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: a proteomics study.

D. Butterfield, R. Sultana, Jian Cai, 2013, Free radical biology & medicine.

Proteomic analysis of brain proteins in APP/PS‐1 human double mutant knock‐in mice with increasing amyloid β‐peptide deposition: Insights into the effects of in vivo treatment with N‐acetylcysteine as a potential therapeutic intervention in mild cognitive impairment and Alzheimer's disease

D. Butterfield, R. Sultana, Jian Cai, 2011, Proteomics.

Metabolic clues to salubrious longevity in the brain of the longest‐lived rodent: the naked mole‐rat

D. Butterfield, Jian Cai, J. Klein, 2015, Journal of neurochemistry.

Structural Basis of G Protein-coupled Receptor-Gi Protein Interaction

Alan Grossfield, Nicholas Leioatts, Dow P Hurst, 2014, The Journal of Biological Chemistry.

Proteomic identification of a novel protein regulated in CA1 and CA3 hippocampal regions during intermittent hypoxia

Jian Cai, W. Pierce, J. Klein, 2003, Respiratory Physiology & Neurobiology.

Proteomic Analysis Reveals Alterations in the Renal Kallikrein Pathway during Hypoxia-Induced Hypertension*

Jian Cai, W. Pierce, J. Klein, 2002, The Journal of Biological Chemistry.

Proteomics Analysis of Molecular Risk Factors in the Ocular Hypertensive Human Retina.

Jian Cai, J. Klein, Xiangjun Yang, 2015, Investigative ophthalmology & visual science.

Hemoglobin expression and regulation in glaucoma: insights into retinal ganglion cell oxygenation.

Jian Cai, W. Pierce, Xiangjun Yang, 2010, Investigative ophthalmology & visual science.

Applications of mass spectrometry in proteomics.

Jian Cai, W. Pierce, 2004, Contributions to nephrology.

Quantitative proteomics analysis of phosphorylated proteins in the hippocampus of Alzheimer's disease subjects.

D. Butterfield, R. Sultana, Jian Cai, 2011, Journal of proteomics.

Proteomic identification of oxidatively modified retinal proteins in a chronic pressure-induced rat model of glaucoma.

Jian Cai, Xiangjun Yang, G. Tezel, 2005, Investigative ophthalmology & visual science.