J. Skehel

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The structure of an HIV-1 specific cell entry inhibitor in complex with the HIV-1 gp41 trimeric core.

S. Schreiber, S. Harrison, G. Zhou, 2000, Bioorganic & medicinal chemistry.

Refinement of the influenza virus hemagglutinin by simulated annealing.

J. Skehel, D. Wiley, A. Brünger, 1991, Journal of molecular biology.

Structure of influenza haemagglutinin at the pH of membrane fusion

J. Skehel, D. Wiley, P. Bullough, 1994, Nature.

Effect of proteolytic processing at two distinct sites on shape and aggregation of an anchorless fusion protein of human respiratory syncytial virus and fate of the intervening segment.

J. Skehel, M. Begoña Ruiz-Argüello, L. González-Reyes, 2002, Virology.

Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin.

J. Skehel, D. Wiley, 2000, Annual review of biochemistry.

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

Peter B Rosenthal, J. Skehel, P. Rosenthal, 2020, Nature.

Cleavage of the human respiratory syncytial virus fusion protein at two distinct sites is required for activation of membrane fusion

J. Skehel, D. Wiley, L. González-Reyes, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution

I. Wilson, J. Skehel, D. Wiley, 1981, Nature.

Conformational changes in the hemagglutinin of influenza virus which accompany heat-induced fusion of virus with liposomes.

J. Skehel, D. Wiley, S. Martin, 1986, Virology.

The receptor‐binding and membrane‐fusion properties of influenza virus variants selected using anti‐haemagglutinin monoclonal antibodies.

J. Skehel, D. Wiley, J. Paulson, 1987, The EMBO journal.

Studies on the structure of the influenza virus haemagglutinin at the pH of membrane fusion.

J. Skehel, D. Wiley, W. Weis, 1988, The Journal of general virology.

A soluble domain of the membrane-anchoring chain of influenza virus hemagglutinin (HA2) folds in Escherichia coli into the low-pH-induced conformation.

W. Weissenhorn, J. Skehel, D. Wiley, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Coiled Coils in Both Intracellular Vesicle and Viral Membrane Fusion

J. Skehel, D. Wiley, John J Skehel, 1998, Cell.

N- and C-terminal residues combine in the fusion-pH influenza hemagglutinin HA(2) subunit to form an N cap that terminates the triple-stranded coiled coil.

J. Skehel, D. Wiley, J. Chen, 1999, Proceedings of the National Academy of Sciences of the United States of America.

The structure and function of the hemagglutinin membrane glycoprotein of influenza virus.

J. Skehel, D. Wiley, D C Wiley, 1987, Annual review of biochemistry.

Amantadine selection of a mutant influenza virus containing an acid-stable hemagglutinin glycoprotein: evidence for virus-specific regulation of the pH of glycoprotein transport vesicles.

J. Skehel, D. Wiley, D. Steinhauer, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Structure of the Hemagglutinin Precursor Cleavage Site, a Determinant of Influenza Pathogenicity and the Origin of the Labile Conformation

David J Stevens, J. Skehel, D. Wiley, 1998, Cell.

H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes

Ya Ha, J. Skehel, D. Wiley, 2002, The EMBO journal.

The Structure and Receptor Binding Properties of the 1918 Influenza Hemagglutinin

D. J. Stevens, J. Skehel, D. Wiley, 2004, Science.

H1 and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes.

J. Skehel, S. Gamblin, R. Russell, 2004, Virology.

Analyses of the antigenicity of influenza haemagglutinin at the pH optimum for virus-mediated membrane fusion.

J. Skehel, D. Wiley, A. Douglas, 1983, The Journal of general virology.

Electron microscopy of antibody complexes of influenza virus haemagglutinin in the fusion pH conformation.

J. Skehel, D. Wiley, R. Ruigrok, 1995, The EMBO journal.

Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals.

J. Skehel, X. Xiong, A. Osterhaus, 2020, Cell host & microbe.

Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin

Alan J. Hay, Xiaoli Xiong, Steven J. Gamblin, 2012, Proceedings of the National Academy of Sciences.

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

J. Skehel, D. Jarrossay, F. Sallusto, 2011, Science.

Influenza Hemagglutinin and Neuraminidase Membrane Glycoproteins

Steven J. Gamblin, J. Skehel, S. Gamblin, 2010, The Journal of Biological Chemistry.

Infectivity Studies of Influenza Virus Hemagglutinin Receptor Binding Site Mutants in Mice

J. Skehel, R. Russell, D. Steinhauer, 2008, Journal of Virology.

Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion

David J Stevens, J. Skehel, S. Gamblin, 2008, Proceedings of the National Academy of Sciences.

Single-particle kinetics of influenza virus membrane fusion

Antoine M. van Oijen, S. Harrison, J. Skehel, 2008, Proceedings of the National Academy of Sciences.

Variation and infectivity neutralization in influenza

J. Skehel, Marcel Knossow, Marcel Knossow, 2006, Immunology.

Avian and human receptor binding by hemagglutinins of influenza A viruses

D. J. Stevens, J. Skehel, S. Gamblin, 2006, Glycoconjugate Journal.

Plasticity of influenza haemagglutinin fusion peptides and their interaction with lipid bilayers.

Franca Fraternali, Jens Kleinjung, J. Skehel, 2005, Biophysical journal.

H1 haemagglutinin receptor complexes

J. Skehel, S. Gamblin, R. Russell, 2004 .

Thermostability of the human respiratory syncytial virus fusion protein before and after activation: implications for the membrane-fusion mechanism.

J. Skehel, D. Martin, B. García-Barreno, 2004, The Journal of general virology.

X-ray structure of the hemagglutinin of a potential H3 avian progenitor of the 1968 Hong Kong pandemic influenza virus.

Ya Ha, David J Stevens, J. Skehel, 2003, Virology.

Genetics of influenza viruses.

David A. Steinhauer, J. Skehel, D. Steinhauer, 2002 .

An antibody that prevents the hemagglutinin low pH fusogenic transition.

J. Skehel, S. Wharton, L. Calder, 2002, Virology.

Mechanism of neutralization of influenza virus infectivity by antibodies.

J. Skehel, A. Douglas, Marcel Knossow, 2002, Virology.

X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs

J. Skehel, D. Wiley, D. Stevens, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation

I. Wilson, J. Skehel, D. Wiley, 1981, Nature.

Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion.

I. Wilson, J. Skehel, D. Wiley, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Electron microscopy of influenza haemagglutinin-monoclonal antibody complexes.

J. Skehel, D. Wiley, A. Douglas, 1983, Virology.

Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity

I. Wilson, J. Skehel, D. Wiley, 1983, Nature.

Antigenic analyses of influenza virus haemagglutinins with different receptor-binding specificities.

C. Naeve, R. Webster, J. Skehel, 1984, Virology.

Studies on the adaptation of influenza viruses to MDCK cells.

J. Skehel, D. Wiley, H. Klenk, 1984, The EMBO journal.

Three-dimensional structure of an antigenic mutant of the influenza virus haemagglutinin

M. Knossow, J. Skehel, D. Wiley, 1984, Nature.

Host-mediated selection of influenza virus receptor variants. Sialic acid-alpha 2,6Gal-specific clones of A/duck/Ukraine/1/63 revert to sialic acid-alpha 2,3Gal-specific wild type in ovo.

J. Skehel, D. Wiley, J. Paulson, 1985, The Journal of biological chemistry.

Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid

S. Cusack, J. Skehel, D. Wiley, 1988, Nature.

Hemagglutinins from two influenza virus variants bind to sialic acid derivatives with millimolar dissociation constants: a 500-MHz proton nuclear magnetic resonance study.

G M Whitesides, G. Whitesides, J. Skehel, 1989, Biochemistry.

Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.

J. Skehel, D. Wiley, J. H. Brown, 1994, Biochemistry.

Crystallographic detection of a second ligand binding site in influenza virus hemagglutinin.

M B Eisen, M. Eisen, J. Knowles, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Crystal structures of influenza virus hemagglutinin in complex with high-affinity receptor analogs.

S. Watowich, J. Skehel, D. Wiley, 1994, Structure.

Structure of influenza virus haemagglutinin complexed with a neutralizing antibody

Pascal Rigolet, Olivier Diat, J. Skehel, 1995, Nature.

A surface plasmon resonance assay for the binding of influenza virus hemagglutinin to its sialic acid receptor.

J. Skehel, D. Wiley, D. Takemoto, 1996, Virology.

Binding of the influenza A virus to cell-surface receptors: structures of five hemagglutinin-sialyloligosaccharide complexes determined by X-ray crystallography.

M B Eisen, M. Eisen, J. Skehel, 1997, Virology.

Antigen distortion allows influenza virus to escape neutralization

Damien Fleury, J. Skehel, S. Wharton, 1998, Nature Structural Biology.

A polar octapeptide fused to the N-terminal fusion peptide solubilizes the influenza virus HA2 subunit ectodomain.

J. Skehel, D. Wiley, J. Chen, 1998, Biochemistry.

Studies of the binding properties of influenza hemagglutinin receptor-site mutants.

J. Skehel, D. Wiley, D. Steinhauer, 1998, Virology.

A complex of influenza hemagglutinin with a neutralizing antibody that binds outside the virus receptor binding site

Damien Fleury, J. Skehel, R. Daniels, 1999, Nature Structural Biology.

The molecular basis of the specific anti‐influenza action of amantadine.

J. Skehel, A. Wolstenholme, A. Hay, 1985, The EMBO journal.

Ground penetrating radar surveys to locate 1918 Spanish flu victims in permafrost.

A. P. Annan, J. Skehel, R. Daniels, 2000, Journal of forensic sciences.

Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors

David J. Stevens, Yukiko Muramoto, Yoshihiro Kawaoka, 2006, Nature.

Structure, Function, and Antigenicity of the Hemagglutinin of Influenza Virus

Don C. Wiley, J. Skehel, D. Wiley, 1989 .

Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma

L. Staudt, W. Chan, G. Lenz, 2009, Proceedings of the National Academy of Sciences.

Analysis of murine antibody responses to baculovirus-expressed human immunodeficiency virus type 1 envelope glycoproteins.

J. Skehel, A. Douglas, R. Daniels, 1994, The Journal of general virology.

Determining the structure of an unliganded and fully glycosylated SIV gp120 envelope glycoprotein.

Don C. Wiley, Bing Chen, Haiyun Gong, 2005 .

Experimental influenza causes a non-permissive viral infection of brain, liver and muscle.

J. Skehel, L. Davis, R. Daniels, 2000, Journal of neurovirology.

SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects

J. Skehel, P. Rosenthal, S. Gamblin, 2020, Nature Structural & Molecular Biology.

Analysis of antigenic variation in equine 2 influenza A viruses.

C. Naeve, R. Webster, J. Skehel, 1983, Bulletin of the World Health Organization.

Purification of virus glycoproteins by affinity chromatography using Lens culinaris phytohaemagglutinin

J. Skehel, M. Crumpton, M. Hayman, 1973, FEBS letters.

I-Ad restricted T cell recognition of influenza hemagglutinin. Synthetic peptides identify multiple epitopes corresponding to antibody-binding regions of the HA1 subunit.

J. Skehel, B. Barnett, D. Burt, 1989, Journal of immunology.

Membrane fusion by influenza hemagglutinin.

J. Skehel, D. Wiley, P. Bullough, 1995, Cold Spring Harbor symposia on quantitative biology.

Influenza A Viruses with Mutations in the M1 Helix Six Domain Display a Wide Variety of Morphological Phenotypes

J. Skehel, D. Steinhauer, L. Calder, 2005, Journal of Virology.

Electron microscopy of the human respiratory syncytial virus fusion protein and complexes that it forms with monoclonal antibodies.

J. Skehel, D. Wiley, L. González-Reyes, 2000, Virology.

Diversity of the class II (I-Ak/I-Ek)-restricted T cell repertoire for influenza hemagglutinin and antigenic drift. Six nonoverlapping epitopes on the HA1 subunit are defined by synthetic peptides

J. Skehel, K. Mills, D. Burt, 1989, The Journal of experimental medicine.

Receptor-binding characteristics of monoclonal antibody-selected antigenic variants of influenza virus

J. Skehel, D. Wiley, P. Underwood, 1987, Journal of virology.

Membrane fusion by peptide analogues of influenza virus haemagglutinin.

J. Skehel, D. Wiley, S. Martin, 1988, The Journal of general virology.

rRNA cleavage as an index of ppp(A2'p)nA activity in interferon-treated encephalomyocarditis virus-infected cells

Silverman, J. Skehel, I. Kerr, 1983, Journal of virology.

Role of virion M2 protein in influenza virus uncoating: specific reduction in the rate of membrane fusion between virus and liposomes by amantadine.

J. Skehel, R. Belshe, S. Wharton, 1994, The Journal of general virology.

Fine specificity of murine class II-restricted T cell clones for synthetic peptides of influenza virus hemagglutinin. Heterogeneity of antigen interaction with the T cell and the Ia molecule.

J. Skehel, K. Mills, D. Burt, 1988, Journal of immunology.

A Human Antibody Recognizing a Conserved Epitope of H5 Hemagglutinin Broadly Neutralizes Highly Pathogenic Avian Influenza H5N1 Viruses

Boping Zhou, J. Skehel, Linqi Zhang, 2012, Journal of Virology.

Avian Influenza H 5 N 1 Viruses Broadly Neutralizes Highly Pathogenic Conserved Epitope of H 5 Hemagglutinin A Human Antibody Recognizing a

Boping Zhou, J. Skehel, Linqi Zhang, 2012 .

Changes in the hemagglutinin of H5N1 viruses during human infection – Influence on receptor binding

J. Farrar, J. Skehel, S. Gamblin, 2013, Virology.

Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2

J. Skehel, P. Rosenthal, S. Gamblin, 2020, Nature Communications.

Crystallization and preliminary X-ray diffraction studies of a monoclonal antibody Fab fragment specific for an influenza virus haemagglutinin and of an escape mutant of that haemagglutinin.

J. Skehel, Y. Mauguen, P. Rigolet, 1990, Journal of molecular biology.

Hemagglutinin Structure and Activities.

J. Skehel, X. Xiong, S. Gamblin, 2020, Cold Spring Harbor perspectives in medicine.

Molecular basis of resistance of influenza A viruses to amantadine.

J. Skehel, A. Wolstenholme, M. Zambon, 1986, The Journal of antimicrobial chemotherapy.

Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein

J. Skehel, P. Rosenthal, S. Gamblin, 2020, Nature Communications.

Transcription of the influenza virus genome.

J. Skehel, A. Bellamy, A. Hay, 1977, Virology.

The polypeptide composition of influenza A viruses.

J. Skehel, G. Schild, 1971, Virology.

Evolution in the Microbial World

J. Skehel, M. Carlile, D. Savile, 1975 .

Evolution of SARS-CoV-2 spike glycoprotein

J. Skehel, P. Rosenthal, S. Gamblin, 2020 .

Amino acid sequences of haemagglutinins of influenza viruses of the H3 subtype isolated from horses.

J. Skehel, D. Wiley, R. Daniels, 1985, The Journal of general virology.

Influenza virus haemagglutinin signal sequence

M. Gething, J. Skehel, J. Bye, 1979, FEBS letters.

In vitro synthesis, glycosylation, and membrane insertion of influenza virus haemagglutinin.

J. Skehel, J. Bye, M. Waterfield, 1979, Virology.

Structure of the haemagglutinin of influenza virus.

J. Skehel, M. Waterfield, K. Espelie, 1979, British medical bulletin.

Nucleotide sequences at the 5' termini of influenza virus RNAs and their transcripts.

J. Skehel, A. Hay, J. J. Skehel, 1978, Nucleic acids research.

Crystallization and x-ray diffraction studies on the haemagglutinin glycoprotein from the membrane of influenza virus.

J. Skehel, D. Wiley, 1977, Journal of molecular biology.

Cellular Events Preceding Interferon Formation

J. Skehel, A. Hay, D. Burke, 2008 .

Antigenic and amino acid sequence analysis of the variants of H1N1 influenza virus in 1986.

J. Skehel, D. Wiley, A. Douglas, 1987, Bulletin of the World Health Organization.

Evidence from studies with a cross-linking reagent that the haemagglutinin of influenza virus is a trimer.

J. Skehel, D. Wiley, M. Waterfield, 1977, Virology.

The influenza A virus nucleoprotein gene controls the induction of both subtype specific and cross-reactive cytotoxic T cells

J. Skehel, A. Townsend, 1984, The Journal of experimental medicine.

On the mechanism of inhibition of influenza virus replication by amantadine hydrochloride.

J. Skehel, A. Hay, J. Armstrong, 1978, The Journal of general virology.

Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH

N. Brown, J. Skehel, P. Rosenthal, 2022, Proceedings of the National Academy of Sciences of the United States of America.

The matrix protein gene determines amantadine-sensitivity of influenza viruses.

J. Skehel, G. Appleyard, A. Hay, 1979, The Journal of general virology.

Gamblin Hemagglutinin The Structure and Receptor Binding Properties of the 1918 Influenza

J. Skehel, D. Wiley, S. Gamblin, 2012 .

Evolution of the SARS-CoV-2 spike protein in the human host

J. Skehel, P. Rosenthal, S. Gamblin, 2021, Nature Communications.

Conformational‐dependent recognition of influenza virus hemagglutinin by murine T helper clones

J. Skehel, K. Mills, D. Thomas, 1986, European journal of immunology.

Recognition of influenza A virus nucleoprotein by an H-2-restricted cytotoxic T-cell clone.

J. Skehel, P. Palese, A. Townsend, 1984, Virology.

Effects of actinomycin D and 2-mercapto-1-(β-4-pyridethyl) benzimidazole on the incorporation of [3H]uridine by chick embryo cells

J. Skehel, A. Hay, L. Cartwright, 1967 .

Targets for the Design of Antiviral Agents: Targets in Orthomyxoviruses

J. Skehel, D. Wiley, 1984 .

Deacylation of the hemagglutinin of influenza A/Aichi/2/68 has no effect on membrane fusion properties.

J. Skehel, D. Wiley, D. Steinhauer, 1991, Virology.

1 – Membrane Fusion by Influenza Viruses and the Mechanism of Action of Amantadine

J. Skehel, S. Wharton, A. Hay, 1990 .

Immune recognition of influenza virus haemagglutinin.

J. Skehel, K. Mills, A. Douglas, 1989, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Preliminary Studies of the Membrane-Associated Portion of the Hemagglutinin

J. Skehel, D. Wiley, 1978 .

Antigenic and amino acid sequence analyses of influenza viruses of the H1N1 subtype isolated between 1982 and 1984.

J. Skehel, D. Wiley, A. Douglas, 1985, Bulletin of the World Health Organization.

Antigenic characterization of influenza A (H1N1) viruses recently isolated from pigs and turkeys in France.

J. Skehel, A. Douglas, M. Aymard, 1985, Bulletin of the World Health Organization.

The size and shape of influenza virus neuraminidase.

J. Skehel, N. G. Wrigley, P. Charlwood, 1973, Virology.

Studies of the Hong Kong Influenza Hemagglutinin

J. Skehel, D. Wiley, 1985 .

Influenza A virus enhances IgE-mediated histamine release from human basophil leukocytes. Examination of the effect of viral neuraminidase and haemagglutinin

J. Skehel, P. Clementsen, A. Douglas, 1989, Agents and Actions.

The Structure of the Small Polypeptide Chain of the Hemagglutinin of an Asian Influenza Virus Japan 305/57 — Bellamy/42 (H2N1)

J. Skehel, M. Waterfield, J. McCauley, 1978 .

The Amino Acid and Carbohydrate Composition of the Neuraminidase of B/Lee/40 Influenza Virus

J. Skehel, V. Yuferov, A. K. Allen, 1977 .

Estimations of the molecular weight of the influenza virus genome.

J. Skehel, 1971, The Journal of general virology.

The preparation and properties of adenovirus cores.

J. Skehel, W. Russell, K. Mcintosh, 1971, The Journal of general virology.

Influenza virus transcription.

J. Skehel, A. Hay, 1978, The Journal of general virology.

Polypeptide synthesis in influenza virus-infected cells.

J. Skehel, 1972, Virology.

Characterization of avian influenza viruses isolated in Israel in 1978-1979.

J. Skehel, D. Shoham, A. Douglas, 1980, Comparative immunology, microbiology and infectious diseases.

Infection of tumour cells by fowl plague virus in the presence of actinomycin D.

J. Skehel, L. Mallucci, 1971, Nature: New biology.

Characterization of temperature-sensitive mutants of adenovirus type 5: synthesis of polypeptides in infected cells.

J. Skehel, W. Russell, J. Williams, 1974, The Journal of general virology.

Structure of an unliganded simian immunodeficiency virus gp120 core

Don C. Wiley, Bing Chen, Haiyun Gong, 2005, Nature.

Atomic structure of the ectodomain from HIV-1 gp41

S. Harrison, W. Weissenhorn, J. Skehel, 1997, Nature.

Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants

Alan J. Hay, Steven J. Gamblin, P. Collins, 2008, Nature.

Ligand recognition by influenza virus. The binding of bivalent sialosides.

J. Knowles, J. Skehel, D. Wiley, 1991, The Journal of biological chemistry.

High level expression of soluble glycoproteins in the allantoic fluid of embryonated chicken eggs using a Sendai virus minigenome system

J. Skehel, B. García-Barreno, J. Melero, 2007 .

J. Skehel, A. Kendal, G. Noble, 1978, Virology.

Studies of the membrane fusion activities of fusion peptide mutants of influenza virus hemagglutinin

J. Skehel, D. Wiley, D. Steinhauer, 1995, Journal of virology.

A carbohydrate side chain on hemagglutinins of Hong Kong influenza viruses inhibits recognition by a monoclonal antibody.

I. Wilson, J. Skehel, D. Wiley, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Studies with crosslinking reagents on the oligomeric structure of the env glycoprotein of HIV.

J. Skehel, D. Wiley, G. Smith, 1989, Virology.

Structural Studies of the Hemagglutinin of the Asian Influenza Virus Japan/305/57 — Bellamy/42 (H2N1).Cyanogen Bromide Cleavage of the Larger Polypeptide Chain HA1

J. Skehel, M. Waterfield, Y. Nakashima, 1978 .

Studies on the primary structure of the influenza virus hemagglutinin.

J. Skehel, M. Waterfield, J J Skehel, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Proton nuclear magnetic resonance studies of the binding of sialosides to intact influenza virus.

J. Skehel, D. Wiley, N. Sauter, 1992, Virology.

Crystalline antigen from the influenza virus envelope.

J. Skehel, C. Brand, 1972, Nature: New biology.

The structure and role of the carbohydrate moieties of influenza virus haemagglutinin.

I. Wilson, J. Skehel, D. Wiley, 1983, Biochemical Society transactions.

Ribonucleic Acid Synthesis in Chick Embryo Cells Infected with Fowl-Plague Virus

J. Skehel, D. Burke, 1969, Journal of virology.

Interferon production and RNA inhibitors.

J. Skehel, D. Burke, S. Walters, 1967, The Journal of general virology.

Temperature dependence of fusion by sendai virus.

J. Skehel, D. Wiley, S. Wharton, 2000, Virology.

Chapter 20 Viral membranes

J. Skehel, D. Wiley, D. Steinhauer, 1998 .

Printed covalent glycan array for ligand profiling of diverse glycan binding proteins.

Chi-Huey Wong, James C Paulson, Ian A Wilson, 2004, Proceedings of the National Academy of Sciences of the United States of America.

SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects

J. Skehel, P. Rosenthal, S. Gamblin, 2020, Nature Structural & Molecular Biology.

Spontaneous and tryptic degradation of virus particles and structural components of adenoviruses.

H. Pereira, J. Skehel, 1971, The Journal of general virology.

Influenza virus infection of a cell-cycle mutant of Chinese hamster ovary cells.

J. Skehel, A. Hay, F. Bosch, 1977, The Journal of general virology.

Virus Replication in Enucleate Cells: Vesicular Stomatitis Virus and Influenza Virus

J. Skehel, C. Pringle, W. Wunner, 1974, Journal of virology.

Interferon action—sequence specificity of the ppp(A2′p)nA-dependent ribonuclease

J. Skehel, I. Kerr, J. McCauley, 1981, Nature.

Cloning and DNA sequence of double-stranded copies of haemagglutinin genes from H2 and H3 strains elucidates antigenic shift and drift in human influenza virus

M. Gething, J. Skehel, J. Bye, 1980, Nature.

REVIEW ARTICLE Influenza Virus Transcription

J. Skehel, A. Hay, 1978 .

Cytotoxic T cells kill influenza virus infected cells but do not distinguish between serologically distinct type A viruses

J. Skehel, M. Crumpton, S. Courtneidge, 1977, Nature.

RNA-dependent RNA polymerase activity of the influenza virus.

J. Skehel, 1971, Virology.

Early polypeptide synthesis in influenza virus-infected cells.

J. Skehel, 1973, Virology.

Studies on the in vitro transcription of reovirus RNA catalyzed by reovirus cores.

J. Skehel, W. Joklik, 1969, Virology.

Characterization of virus-specific messenger RNAs from avian fibroblasts infected with fowl plague virus.

J. Stephenson, J. Skehel, A. Hay, 1977, The Journal of general virology.

The polypeptides of adenovirus-infected cells.

J. Skehel, W. Russell, 1972, The Journal of general virology.

The molecular basis of microbial pathogenicity: report of the Dahlem Workshop, Berlin, 22-26 October 1979.

J. Skehel, M. Turner, H. Smith, 1980 .

Comparative analyses of the specificities of anti-influenza hemagglutinin antibodies in human sera

J. Skehel, D. Wiley, M. L. Wang, 1986, Journal of virology.

The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design

David J. Stevens, Alan J. Hay, Steven J. Gamblin, 2006, Nature.

H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis

P. Collins, J. Skehel, X. Xiong, 2012, PLoS pathogens.

H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis

P. Collins, J. Skehel, X. Xiong, 2012, PLoS pathogens.

Structural basis for oseltamivir resistance of influenza viruses.

P. Collins, J. Skehel, S. Martin, 2009, Vaccine.

The immunotargeting approach to adjuvant-independent immunization with influenza haemagglutinin.

J. Skehel, A. Douglas, B. Barber, 1993, Vaccine.

Structural basis for membrane fusion by enveloped viruses.

S. Harrison, W. Weissenhorn, J. Skehel, 1999, Molecular membrane biology.

The polypeptide composition of mouse mammary tumor virus.

J. Skehel, C. Dickson, 1974, Virology.

The immune response of BALB/c mice to influenza hemagglutinin: commonality of the B cell and T cell repertoires and their relevance to antigenic drift

J. Skehel, B. Barnett, D. Burt, 1989, European journal of immunology.

Recent evolution of equine influenza and the origin of canine influenza

P. Collins, J. Skehel, X. Xiong, 2014, Proceedings of the National Academy of Sciences.

Receptor binding by an H7N9 influenza virus from humans

P. Collins, J. Skehel, X. Xiong, 2013, Nature.

Influenza A specific cytotoxic T-cell clones that do not recognize viral glycoproteins

J. Skehel, A. Townsend, 1982, Nature.

Cytotoxic T cells to type A influenza virus; viral hemagglutinin induces A‐strain specificity while infected cells confer cross‐reactive cytotoxicity

J. Skehel, S. Courtneidge, B. Askonas, 1977, European journal of immunology.

Influenza glycoproteins: Hemagglutinin and neuraminidase

J. Skehel, S. Gamblin, R. Russell, 2013 .

Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain.

W. Weissenhorn, J. Skehel, D. Wiley, 1998, Molecular cell.

Receptor binding by a ferret-transmissible H5 avian influenza virus

Yoshihiro Kawaoka, Xiaoli Xiong, Steven J. Gamblin, 2013, Nature.

The ectodomain of HIV‐1 env subunit gp41 forms a soluble, alpha‐helical, rod‐like oligomer in the absence of gp120 and the N‐terminal fusion peptide.

P. Earl, B. Moss, W. Weissenhorn, 1996, The EMBO journal.

Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes

P. Collins, J. Skehel, F. Sallusto, 2016, Cell.

A neutralizing antibody Fab-influenza haemagglutinin complex with an unprecedented 2:1 stoichiometry: characterization and crystallization.

J. Skehel, R. Daniels, Marcel Knossow, 2000, Acta crystallographica. Section D, Biological crystallography.

Potent adaptive immune responses induced against HIV-1 gp140 and influenza virus HA by a polyanionic carbomer.

Q. Sattentau, J. Skehel, J. Heeney, 2010, Vaccine.

Extensive diversity in the recognition of influenza virus hemagglutinin by murine T helper clones

J. Skehel, K. Mills, D. Thomas, 1986, The Journal of experimental medicine.

Proteins synthesized in chick cells following infection with Semliki Forest virus.

J. Skehel, A. Hay, D. Burke, 1968, The Journal of general virology.

A single amino acid substitution in influenza hemagglutinin abrogates recognition by monoclonal antibody and a spectrum of subtype‐specific L3T4+ T cell clones

J. Skehel, K. Mills, Christine M. Graham, 1987, European journal of immunology.

Fred Brown. 31 January 1925 — 20 February 2004

J. Skehel, D. Rowlands, 2007, Biographical Memoirs of Fellows of the Royal Society.

Structural evidence for recognition of a single epitope by two distinct antibodies

J. Skehel, R. Daniels, Marcel Knossow, 2000, Proteins.

Refined three-dimensional structure of the Fab fragment of a murine IgGl,lambda antibody.

J. Skehel, B. Golinelli‐Pimpaneau, R. Daniels, 1994, Acta crystallographica. Section D, Biological crystallography.

Suicide selection of murine T helper clones specific for variable regions of the influenza hemagglutinin molecule

J. Skehel, K. Mills, C. Graham, 1986, European journal of immunology.

Sequential mutations in hemagglutinins of influenza B virus isolates: definition of antigenic domains.

I. Wilson, J. Skehel, D. Wiley, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Sequence elements of the fusion peptide of human respiratory syncytial virus fusion protein required for activity.

J. Skehel, D. Martin, B. García-Barreno, 2006, The Journal of general virology.

Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements

Stuart L. Schreiber, Don C. Wiley, Winfried Weissenhorn, 1999, Nature Structural Biology.

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

J. Skehel, P. Rosenthal, S. Gamblin, 2020, Nature.

The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2

J. Skehel, P. Rosenthal, S. Gamblin, 2021, Proceedings of the National Academy of Sciences.

Virus nucleic acid and interferon formation.

J. Skehel, D. Burke, 1967, The Biochemical journal.

Crystals of a fragment of influenza haemagglutinin in the low pH induced conformation.

J. Skehel, D. Wiley, R. Ruigrok, 1994, Journal of Molecular Biology.

Studies using double mutants of the conformational transitions in influenza hemagglutinin required for its membrane fusion activity.

J. Skehel, D. Wiley, D. Steinhauer, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Are peptides good antigens?

J. Skehel, G. Ada, 1985, Nature.

Membrane fusion by surrogate receptor-bound influenza haemagglutinin.

J. Skehel, D. Wiley, L. Calder, 1999, Virology.

The central structural feature of the membrane fusion protein subunit from the Ebola virus glycoprotein is a long triple-stranded coiled coil.

W. Weissenhorn, J. Skehel, D. Wiley, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Introduction of intersubunit disulfide bonds in the membrane-distal region of the influenza hemagglutinin abolishes membrane fusion activity

J. Skehel, D. Wiley, B. Ely, 1992, Cell.

The structural requirements for class II (I‐Ad)‐restricted T cell recognition of influenza hemagglutinin: B cell epitopes define T cell epitopes

J. Skehel, B. Barnett, D. Burt, 1989, European journal of immunology.

Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957

J. Skehel, S. Gamblin, R. Russell, 2009, Proceedings of the National Academy of Sciences.

Recovery of an Antiviral Antibody Response following Attrition Caused by Unrelated Infection

J. Skehel, J. Langhorne, G. Kassiotis, 2014, PLoS pathogens.

Composition and functions of the influenza fusion peptide.

J. Skehel, R. Russell, D. Steinhauer, 2009, Protein and peptide letters.

Interferon production and viral ribonucleic acid synthesis in chick embryo cells.

J. Skehel, D. Burke, M. Low, 1967, The Journal of general virology.

Interferon production by Semliki Forest virus inactivated with hydroxylamine.

J. Skehel, D. Burke, 1968, The Journal of general virology.

A temperature-sensitive event in interferon production.

J. Skehel, D. Burke, 1968, The Journal of general virology.

Interferons and other cell products influencing viral multiplication.

J. Skehel, D. Burke, 1967, British medical bulletin.

Structural transitions in influenza haemagglutinin at membrane fusion pH

J. Skehel, P. Rosenthal, S. Gamblin, 2020, Nature.

Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza C virus

J. Skehel, D. Wiley, Chi‐Huey Wong, 1998, Nature.

Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza C virus

J. Skehel, D. Wiley, Chi‐Huey Wong, 1998, Nature.

Expression Cloning and Production of Human Heavy-Chain-Only Antibodies from Murine Transgenic Plasma Cells

F. Grosveld, J. Skehel, Johannes Kloess, 2016, Frontiers in immunology.

Analysis of residues near the fusion peptide in the influenza hemagglutinin structure for roles in triggering membrane fusion.

J. Skehel, R. Russell, D. Steinhauer, 2008, Virology.

X‐ray crystallographic determination of the structure of the influenza C virus haemagglutinin‐esterase‐fusion glycoprotein

J. Skehel, D. Wiley, Chi‐Huey Wong, 1999, Acta crystallographica. Section D, Biological crystallography.

The polypeptides of adenovirus type 12.

J. Skehel, W. Russell, 1973, The Journal of general virology.

Influenza viruses and cell membranes.

J. Skehel, D. Wiley, 1995, American journal of respiratory and critical care medicine.

Antigenicity of the Influenza Haemagglutinin Membrane Glycoprotein

J. Skehel, D. Wiley, 1987 .

The characterization of subviral particles derived from influenza virus.

J. Skehel, 1971, Virology.

The origin of pandemic influenza viruses.

J. Skehel, 1974 .

Antigenic and amino acid sequence variations in the haemagglutinins of type A influenza viruses recently isolated from human subjects.

J. Skehel, D. Wiley, A. Douglas, 1983, Bulletin of the World Health Organization.

Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus.

J. Skehel, X. Xiong, S. Martin, 2013, Virus research.

Receptor binding by H10 influenza viruses

Xiaoli Xiong, Steven J. Gamblin, John W. McCauley, 2014, Nature.

Enhanced human receptor binding by H5 haemagglutinins

P. Collins, J. Skehel, X. Xiong, 2014, Virology.

Helio Gelli Pereira. 23 September 1918 — 16 August 1994

J. Skehel, D. Tyrrell, 1999, Biographical Memoirs of Fellows of the Royal Society.

Procedures for characterisation of the genetic material of candidate vaccine strains.

R. Webster, J. Skehel, A. Bellamy, 1977, Developments in biological standardization.

Genetic composition and virulence of influenza virus: differences in facets of virulence in ferrets between two pairs of recombinants with RNA segments of the same parental origin.

J. Skehel, T. J. Mason, A. Douglas, 1982, The Journal of general virology.

Differentiation of the haemagglutinin genes of variant influenza viruses by RNA-RNA hybridization.

R. Webster, J. Skehel, A. Hay, 1979, The Journal of general virology.

Studies of influenza haemagglutinin-mediated membrane fusion.

J. Skehel, D. Wiley, S. Wharton, 1986, Virology.

Influenza virus messenger RNAs are incomplete transcripts of the genome RNAs.

J. Skehel, A. Hay, J. Smith, 1977, Nucleic acids research.

Adaptation of egg-grown and transfectant influenza viruses for growth in mammalian cells: selection of hemagglutinin mutants with elevated pH of membrane fusion.

J. Skehel, D. Wiley, D. Steinhauer, 1997, Virology.

An overview of influenza haemagglutinin and neuraminidase.

J. Skehel, 2009, Biologicals : journal of the International Association of Biological Standardization.

The conformation of influenza virus haemagglutinin

J. Skehel, M. T. Flanagan, 1977, FEBS letters.

Electron microscopy of the low pH structure of influenza virus haemagglutinin.

J. Skehel, S. Cusack, R. Ruigrok, 1986, The EMBO journal.

Nucleotide sequences at the terminal of La Crosse virus RNAs.

J. Skehel, J. McCauley, J. Obijeski, 1980, Nucleic acids research.

Sequential receptor binding primes the SARS-CoV-2 S glycoprotein for membrane fusion

J. Skehel, S. Gamblin, D. Benton, 2020 .

Correction for Basner et al., Mars 520-d mission simulation reveals protracted crew hypokinesis and alterations of sleep duration and timing

J. Skehel, X. Xiong, S. Gamblin, 2013, Proceedings of the National Academy of Sciences.

Studies on influenza haemagglutinin fusion peptide mutants generated by reverse genetics

J. Skehel, D. Wiley, D. Steinhauer, 2001, The EMBO journal.

The structure of a membrane fusion mutant of the influenza virus haemagglutinin.

J. Skehel, D. Wiley, W. Weis, 1990, The EMBO journal.

Electron microscopic evidence for the axial rotation and inter-domain flexibility of the Fab regions of immunoglobulin G.

J. Skehel, N. G. Wrigley, E. Brown, 1983, Journal of molecular biology.

Immunology: Are peptides good antigens?

J. Skehel, G. Ada, 1985, Nature.

FRS 1981 20 February 2004 : Elected − − Fred Brown . 31 January 1925

J. Skehel, D. Rowlands, 2007 .

Conformational aspects of the acid-induced fusion mechanism of influenza virus hemagglutinin. Circular dichroism and fluorescence studies.

J. Skehel, D. Wiley, W. Weis, 1988, The Journal of biological chemistry.

Disulphide bonds of haemagglutinin of Asian influenza virus

J. Skehel, M. Waterfield, G. Scrace, 1981, Nature.

Epitope mapping of cross-reactive monoclonal antibodies specific for the influenza A virus PA and PB2 polypeptides.

J. Skehel, S. de la Luna, J. Melero, 1995, Virus research.

Assembly of a rod-shaped chimera of a trimeric GCN4 zipper and the HIV-1 gp41 ectodomain expressed in Escherichia coli.

W. Weissenhorn, J. Skehel, D. Wiley, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Influenza virus transcription.

J. Skehel, A. Hay, 1978, The Journal of general virology.

Structural studies on viral escape from antibody neutralization.

J. Skehel, Marcel Knossow, C. Barbey-Martin, 2001, Current topics in microbiology and immunology.

Structure and synthesis of influenza virus complementary RNAs.

J. Skehel, A. Hay, J. McCauley, 1980, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Evasion of host defenses: group report.

A. Tomasz, J. Skehel, D. Wiley, 1980 .

Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Virus between Mammals

J. Skehel, X. Xiong, A. Osterhaus, 2020 .

Expression, Purification, and Characterization of gp160e, the Soluble, Trimeric Ectodomain of the Simian Immunodeficiency Virus Envelope Glycoprotein, gp160*

S. Harrison, E. Reinherz, J. Skehel, 2000, The Journal of Biological Chemistry.

Amantadine blocks the channel

J. Skehel, 1992, Nature.

Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody

P. Collins, J. Skehel, X. Xiong, 2015, Proceedings of the National Academy of Sciences.

Determining the structure of an unliganded and fully glycosylated SIV gp120 envelope glycoprotein.

S. Harrison, J. Skehel, D. Wiley, 2005, Structure.

A Novel I221L Substitution in Neuraminidase Confers High-Level Resistance to Oseltamivir in Influenza B Viruses

P. Collins, J. Skehel, S. Gamblin, 2014, The Journal of infectious diseases.

A Novel I 221 L Substitution in Neuraminidase Confers High-Level Resistance to Oseltamivir in In fl uenza B Viruses

P. Collins, J. Skehel, S. Gamblin, 2014 .

Human former seasonal Influenza A(H1N1) haemagglutination inhibition data 1977-2009 from the WHO Collaborating Centre for Reference and Research on Influenza, London, UK

William T. Harvey, J. Skehel, D. Haydon, 2016 .

The structure of the influenza virus haemagglutinin glycoprotein at 3 Ã resolution

Ian A. Wilson, Don C. Wiley, I. Wilson, 1981 .

A Chimeric Protein of Simian Immunodeficiency Virus Envelope Glycoprotein gp140 and Escherichia coli Aspartate Transcarbamoylase

S. Harrison, E. Reinherz, J. Skehel, 2004, Journal of Virology.

Influenza virus. Amantadine blocks the channel.

J. Skehel, 1992, Nature.

Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes

P. Collins, J. Skehel, F. Sallusto, 2016, Cell.

High level expression of soluble glycoproteins in the allantoic fluid of embryonated chicken eggs using a Sendai virus minigenome system

J. Skehel, B. García-Barreno, J. Melero, 2007 .

Studies on low pH-activated HA2 from influenza haemagglutinin

J. Skehel, S. Gamblin, L. Haire, 2017 .

Crystallization and preliminary X‐ray diffraction studies of the influenza C virus glycoprotein

J. Skehel, D. Wiley, J. Newman, 1996, Acta Crystallographica Section D: Biological Crystallography.

PRELIMINARY CRYSTALLOGRAPHIC REPORTS Crystallization and Preliminary X-Ray Diffraction Studies of Complexes Between an Influenza Hemagglutinin and Fab Fragments of Two Different Monoclonal Antibodies

J. Skehel, Marcel Knossow, B. Gigant, 2003 .

Changes in the conformation of inf the pH optimum of virus-mediated (virus glycoprotein/lipid binding/detergent binding)

I. Wilson, J. Skehel, D. Wiley, 2016 .

Structural changes in influenza virus haemagglutinin at the pH of membrane fusion.

J. Skehel, R. Ruigrok, S. Wharton, 1986, Biochemical Society Transactions.

Studies on the structure of the haemagglutinin.

J. Skehel, D. Wiley, M. Waterfield, 1980, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

The Influenza Virus Mechanical Properties Are Dominated By Its Lipid Envelope

J. Skehel, C. Veigel, A. D. Georges, 2009 .

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

J. Skehel, D. Jarrossay, F. Sallusto, 2011, Science.

INFLUENZA ACTIVITY - UNITED-STATES AND WORLDWIDE - COMPOSITION OF THE 1992-1993 INFLUENZA VACCINE (REPRINTED FROM MMWR, VOL 41, PG 315-323, 1992)

Gust, J. Skehel, G. Schild, 1992 .

Studies on the Structure and Activities of Influenza Virus Haemagglutinin

I. Wilson, J. Skehel, D. Wiley, 1984 .

Author Correction: SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects

J. Skehel, P. Rosenthal, S. Gamblin, 2020, Nature Structural & Molecular Biology.

Ligand Recognition by Influenza Virus

J. Skehel, D. Wiley, L. Peter, 1991 .

Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.

J. Skehel, D. Wiley, N. Sauter, 1994, Biochemistry.

A great ape perspective on the origins and evolution of human viruses

J. Skehel, J. Overbaugh, T. Mettenleiter, 2011 .