G. Maley

发表

Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate.

R. Stroud, W. Montfort, K. M. Perry, 1990 .

The enzymic conversion of glucosamine to galactosamine.

G. Maley, F. Maley, 1959, Biochimica et biophysica acta.

Phosphorylation coupled with the oxidation of reduced cytochrome c.

G. Maley, H. Lardy, 1954, The Journal of biological chemistry.

Yields of oxidative phosphorylation by heart mitochondria.

G. Maley, G. Plaut, 1953, The Journal of biological chemistry.

Factors affecting substrate binding in Lactobacillus casei thymidylate synthetase as studied by equilibrium dialysis.

G. Maley, F. Maley, J. Galivan, 1976, Biochemistry.

Oxidative phosphorylation by sonic extracts of mitochondria.

W. C. McMurray, G. Maley, H. Lardy, 1958, The Journal of biological chemistry.

Thymidylate synthase binds to c-myc RNA in human colon cancer cells and in vitro

G. Maley, F. Maley, C. Allegra, 1995, Molecular and cellular biology.

Chromosomal Location and Structural Organization of the Human Deoxycytidylate Deaminase Gene (*)

G. Maley, F. Maley, A. Jaffe, 1995, The Journal of Biological Chemistry.

Three-dimensional structure of the R115E mutant of T4-bacteriophage 2'-deoxycytidylate deaminase.

G. Maley, F. Maley, R. Maccoll, 2004, Biochemistry.

Studies on identifying the binding sites of folate and its derivatives in Lactobacillus casei thymidylate synthase.

G. Maley, F. Maley, 1983, Advances in experimental medicine and biology.

Efficiency of phosphorylation in selected oxidations by mitochondria from normal and thyrotoxic rat livers.

G. Maley, H. Lardy, 1955, The Journal of biological chemistry.

Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli.

G. Maley, F. Maley, K. X. Weiner, 1993, The Journal of biological chemistry.

THE SITE OF ACTION OF FLUOROURACIL IN RELATION TO THE AMINO ACID SEQUENCE OF THYMIDYLATE SYNTHETASE

G. Maley, F. Maley, 1979 .

Intervening sequence in the thymidylate synthase gene of bacteriophage T4.

M. Belfort, G. Maley, F. Maley, 1984, Proceedings of the National Academy of Sciences of the United States of America.

In vitro expression of the intron-containing gene for T4 phage thymidylate synthase.

M. Belfort, G. Maley, F. Maley, 1985, The Journal of biological chemistry.

Nucleotide interconversions. VIII. Thymidine-sparing effect on the utilization of de-cytidine by chick-embryo mince.

G. Maley, F. Maley, 1963, Biochimica et biophysica acta.

Nucleotide interconversions. II. Elevation of deoxycytidylate deaminase and thymidylate synthetase in regenerating rat liver.

G. Maley, F. Maley, 1960, The Journal of biological chemistry.

The effect of methotrexate on enzymes induced following partial hepatectomy.

G. Maley, F. Maley, R. Labow, 1969, Cancer research.

Cloning, sequence analysis, and expression of the bacteriophage T4 cd gene.

G. Maley, F. Maley, A. M. Wang, 1990, The Journal of biological chemistry.

Complete amino acid sequence of an allosteric enzyme, T2 bacteriophage deoxycytidylate deaminase.

G. Maley, F. Maley, D. Guarino, 1983, The Journal of biological chemistry.

Role of substrate depletion in the inhibition of thymidylate biosynthesis by the dihydrofolate reductase inhibitor trimetrexate in cultured hepatoma cells.

G. Maley, F. Maley, D. Priest, 1990, Cancer research.

Purification and properties of T2 bacteriophage-induced thymidylate synthetase.

G. Maley, F. Maley, J. Galivan, 1974, Biochemistry.

Localization of the T4 phage ribonucleotide reductase B1 subunit gene and the nucleotide sequence of its upstream and 5' coding regions.

G. Maley, F. Maley, A. M. Wang, 1987, Gene.

Characterization of the intron in the phage T4 thymidylate synthase gene and evidence for its self-excision from the primary transcript

M. Belfort, G. Maley, F. Maley, 1986, Cell.

Tetrahydrodeoxyuridylate: a potent inhibitor of deoxycytidylate deaminase.

G. Maley, F. Maley, 1971, Archives of biochemistry and biophysics.

High-level expression of Escherichia coli and Bacillus subtilis thymidylate synthases.

G. Maley, F. Maley, V. Frasca, 2000, Protein expression and purification.

A single functional arginyl residue involved in the catalysis promoted by Lactobacillus casei thymidylate synthetase.

M. Belfort, G. Maley, F. Maley, 1980, Archives of biochemistry and biophysics.

Properties of a defined mutant of Escherichia coli thymidylate synthase.

G. Maley, F. Maley, 1988, The Journal of biological chemistry.

Purification and properties of T4 phage thymidylate synthetase produced by the cloned gene in an amplification vector.

M. Belfort, G. Maley, F. Maley, 1983, The Journal of biological chemistry.

Interrupted thymidylate synthase gene of bacteriophages T2 and T6 and other potential self-splicing introns in the T-even bacteriophages

G. Maley, F. Maley, J. Martínez, 1987, Journal of bacteriology.

Intron‐associated splicing reactions in bacteriophage T4

G. Maley, F. Maley, F. Chu, 1990, Molecular microbiology.

RNA splicing in the T‐even bacteriophage

G. Maley, F. Maley, F. Chu, 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Crystal structure of a deletion mutant of human thymidylate synthase Δ (7–29) and its ternary complex with Tomudex and dUMP

G. Maley, F. Maley, P. Van Roey, 2001, Protein science : a publication of the Protein Society.

Properties of an affinity-column-purified human deoxycytidylate deaminase.

G. Maley, F. Maley, A. Lobo, 1993, Biochimica et biophysica acta.

On the nature of a sparing effect by thymidine on the utilization of deoxycytidine.

G. Maley, F. Maley, 1962, Biochemistry.

A simplified enzymic procedure for the preparation of nucleoside di- and triphosphates.

G. Maley, F. Maley, J. F. McGarrahan, 1967, Analytical biochemistry.

The purification and properties of thymidylate synthetase from chick embryo extracts.

G. Maley, F. Maley, M. Lorenson, 1967, The Journal of biological chemistry.

Properties of bacteriophage T4 thymidylate synthase following mutagenic changes in the active site and folate binding region.

G. Maley, F. Maley, L. LaPat-Polasko, 1990, Biochemistry.

The isolation, synthesis, and metabolic properties of 6, 7-dimethyl-8-ribityllumazine.

G. Maley, G. Plaut, 1959, The Journal of biological chemistry.

The effect of substrate analogs on the circular dichroic spectra of thymidylate synthetase from Lactobacillus casei.

G. Maley, F. Maley, J. Galivan, 1975, Biochemistry.

Synthesis of 6-methyl-7-hydroxy-8-ribityllumazine and its identification with a blue-violet fluorescent substance from Ashbya gossypii☆

G. Maley, G. Plaut, 1959 .

Primary structure of the Streptomyces enzyme endo-beta-N-acetylglucosaminidase H.

K. Biemann, G. Maley, F. Maley, 1984, The Journal of biological chemistry.

Inhibiyors of protein synthesis: Effect on the levels of deoxycytidylate deaminase, thymidylate synthetase, and thymidine kinase in regenerating rat liver☆

G. Maley, F. Maley, M. Lorenson, 1965 .

Nucleotide interconversions. IV. Activities of deoxycytidylate deaminase and thymidylate synthetase in normal rat liver and hepatomas.

G. Maley, F. Maley, 1961, Cancer research.

INHIBITORS OF PROTEIN SYNTHESIS: EFFECT ON THE LEVELS OF DEOXYCYTIDYLATE DEAMINASE, THYMIDYLATE SYNTHETASE, AND THYMIDINE KINASE IN REGENERATING RAT LIVER.

G. Maley, F. Maley, M. Lorenson, 1965, Biochemical and biophysical research communications.

Nucleotide interconversions V. Incorporation of deoxyadenylate into the deoxyguanylate of deoxyribonucleic acid

G. Maley, F. Maley, 1961 .

Inhibition of deoxyribonucleic acid synthesis in chick embryos by deoxyadenosine.

G. Maley, F. Maley, 1960, The Journal of biological chemistry.

The Regulatory Influence of Allosteric Effectors on Deoxycytidylate Deaminases

G. Maley, F. Maley, 1972 .

The primary structure of Lactobacillus casei thymidylate synthetase. III. The use of 2-(2-nitrophenylsulfenyl)-3-methyl-3-bromoindolenine and limited tryptic peptides to establish the complete amino acid sequence of the enzyme.

G. Maley, F. Maley, R. Bellisario, 1979, The Journal of biological chemistry.

The Synthesis of α-D-Glucosamine-1-phosphate and N-Acetyl-α-D-glucosamine-1-phosphate. Enzymatic Formation of Uridine Diphosphoglucosamine1

G. Maley, F. Maley, H. Lardy, 1956 .

Nucleotide interconversions. X. Deoxyribo- and ribonucleoside 5'-phosphate synthesis via a phosphotransferase reaction in chick embryo extracts.

G. Maley, F. Maley, Frank Maley, 1963, Archives of biochemistry and biophysics.

[54] Deoxycytidylate deaminase from T2-infected Escherichia coli

G. Maley, 1978 .

Deoxycytidylate deaminase from T2-infected Escherichia coli.

G. Maley, 1978, Methods in Enzymology.

Mechanisms of enzyme modulation involving deoxycytidylate deaminase and thymidylate synthetase.

G. Maley, F. Maley, 1970, Advances in enzyme regulation.

Regulatory properties and subunit structure of chick embryo deoxycytidylate deaminase.

G. Maley, F. Maley, 1968, The Journal of biological chemistry.

Nucleotide interconversions in embryonic and neoplastic tissues. I. The conversion of deoxycytidylic acid to deoxyuridylic acid and thymidylic acid.

G. Maley, F. Maley, 1959, The Journal of biological chemistry.

A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase.

G. Maley, F. Maley, 1990, Progress in nucleic acid research and molecular biology.

Probing the infra-structure of thymidylate synthase and deoxycytidylate deaminase.

M. Belfort, G. Maley, F. Maley, 1984, Advances in enzyme regulation.

Allosteric transitions associated with the binding of substrate and effector ligands to T2 phage induced deoxycytidylate deaminase.

G. Maley, F. Maley, 1982, Biochemistry.

The in vitro synthesis of T2 bacteriophage-induced deoxycytidylate deaminase and its regulation by allosteric effectors.

G. Maley, F. Maley, R. B. Trimble, 1972, Archives of biochemistry and biophysics.

Chloroviruses Encode a Bifunctional dCMP-dCTP Deaminase That Produces Two Key Intermediates in dTTP Formation

J. V. Van Etten, G. Maley, F. Maley, 2007, Journal of Virology.

The presence of deoxycytidylate deaminase in normal adult rat liver.

G. Maley, F. Maley, 1961, Biochimica et biophysica acta.

THE PURIFICATION AND PROPERTIES OF DEOXYCYTIDYLATE DEAMINASE FROM CHICK EMBRYO EXTRACTS.

G. Maley, F. Maley, 1964, The Journal of biological chemistry.

Amino acid sequence at the FdUMP binding site of thymidylate synthetase.

G. Maley, F. Maley, J. Galivan, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A.

R. Stroud, E. Fauman, G. Maley, 1994, Biochemistry.

Nucleotide interconversions. III. The incorporation in vitro of deoxycytidylate into the deoxycytidine and thymidine of deoxyribonucleic acid.

G. Maley, F. Maley, 1961, The Journal of biological chemistry.

Identification of an RNA binding site for human thymidylate synthase.

G. Maley, F. Maley, C. Takimoto, 1993, Proceedings of the National Academy of Sciences of the United States of America.

T2r + bacteriophage-induced enzymes. I. The purification and properties of deoxycytidylate deaminase.

G. Maley, F. Maley, D. Guarino, 1972, The Journal of biological chemistry.

T2r + bacteriophage-induced enzymes. II. The subunit structure of deoxycytidylate deaminase.

G. Maley, F. Maley, R. Maccoll, 1972, The Journal of biological chemistry.

End Product Regulation of Bacteriophage T2 r+-induced Deoxycytidylate Deaminase

G. Maley, F. Maley, D. Guarino, 1967 .

Thymidylate Synthase Protein and p53 mRNA Form an In Vivo Ribonucleoprotein Complex

G. Maley, F. Maley, C. Allegra, 1999, Molecular and Cellular Biology.

Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells

G. Maley, F. Maley, C. Allegra, 1994, Molecular and cellular biology.

Mechanism and requirements of in vitro RNA splicing of the primary transcript from the T4 bacteriophage thymidylate synthase gene.

G. Maley, F. Maley, F. Chu, 1987, Biochemistry.

Oxidative phosphorylation by heart muscle mitochondria.

G. Maley, G. Plaut, 1954, Biochimica et biophysica acta.

The primary structure of Lactobacillus casei thymidylate synthetase. II. The complete amino acid sequence of the active site peptide, CNBr 4.

G. Maley, F. Maley, R. Bellisario, 1979, The Journal of biological chemistry.

Characterization of the Escherichia coli thyA gene and its amplified thymidylate synthetase product.

M. Belfort, G. Maley, F. Maley, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Relationship Between Escherichia coli B Titer and the Level of Deoxycytidylate Deaminase Activity Induced on Bacteriophage T2r+ Infection

G. Maley, F. Maley, R. B. Trimble, 1972, Journal of virology.

Characterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA.

G. Maley, F. Maley, X. Lin, 2000, Nucleic acids research.

Comparison of some enzyme systems in normal and thyrotoxic rat livers.

G. Maley, 1956, The American journal of physiology.

Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate.

R M Stroud, R. Stroud, K. M. Perry, 1990, Biochemistry.

RNA splicing and in vivo expression of the intron-containing td gene of bacteriophage T4.

L. Gold, M. Belfort, G. Maley, 1986, Gene.

Metabolic effects of thyroid hormones in vitro. II. Influence of thyroxine and triiodothyronine on oxidative phosphorylation.

G. Maley, H. Lardy, 1953, The Journal of biological chemistry.

The primary structure of Lactobacillus casei thymidylate synthetase. I. The isolation of cyanogen bromide peptides 1 through 5 and the complete amino acid sequence of CNBr 1, 2, 3, and 5.

G. Maley, F. Maley, R. Bellisario, 1979, The Journal of biological chemistry.

Characterization of the restriction site of a prokaryotic intron-encoded endonuclease.

G. Maley, F. Maley, A. M. Wang, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Structure of the Y94F mutant of Escherichia coli thymidylate synthase.

G. Maley, F. Maley, W. Montfort, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Intracellular Location of Thymidylate Synthase and Its State of Phosphorylation*

G. Maley, F. Maley, M. Mckee, 1997, The Journal of Biological Chemistry.

Isolation and expression of rat thymidylate synthase cDNA: phylogenetic comparison with human and mouse thymidylate synthases.

G. Maley, F. Maley, J. Reston, 1995, Biochimica et biophysica acta.

Crystal structure of thymidylate synthase from T4 phage: component of a deoxynucleoside triphosphate-synthesizing complex.

R. Stroud, J. Finer-Moore, G. Maley, 1994, Biochemistry.

Plastic adaptation toward mutations in proteins: Structural comparison of thymidylate synthases

R. Stroud, K. M. Perry, E. Fauman, 1990, Proteins.

Studies on identifying the folylpolyglutamate binding sites of Lactobacillus casei thymidylate synthetase.

G. Maley, F. Maley, C. Baugh, 1982, Archives of biochemistry and biophysics.

An anomaly in the active site region of thymidylate synthase.

G. Maley, F. Maley, 1989, Advances in enzyme regulation.

DISCUSSION PAPER: THE APPARENT INDUCTION OF THYMIDYLATE SYNTHETASE BY AMETHOPTERIN *

G. Maley, F. Maley, 1971, Annals of the New York Academy of Sciences.

Significance of mutations on the structural perturbation of thymidylate synthase: Implications for their involvement in subunit exchange

G. Maley, F. Maley, C. Hauer, 2007, Protein science : a publication of the Protein Society.

Overcoming inclusion body formation in a high-level expression system.

G. Maley, F. Maley, J. Moore, 1993, Protein expression and purification.

A T4-phage Deoxycytidylate Deaminase Mutant That No Longer Requires Deoxycytidine 5′-Triphosphate for Activation*

G. Maley, F. Maley, R. Saxl, 2000, The Journal of Biological Chemistry.

Identification of a site necessary for allosteric regulation in T4-phage deoxycytidylate deaminase.

G. Maley, F. Maley, J. Moore, 1994, Biochemistry.

Studies on identifying the allosteric binding sites of deoxycytidylate deaminase.

G. Maley, F. Maley, 1982, The Journal of biological chemistry.

High-level expression of human thymidylate synthase.

G. Maley, F. Maley, E. Chu, 1997, Protein expression and purification.

THE CONVERSION OF 6,7-DIMETHYL-8-RIBITYLLUMAZINE (6,7-DIMETHYL-8-RIBITYL-2,4[1H,3H]-PTERIDINEDIONE) TO RIBOFLAVIN BY EXTRACTS OF ASHBYA GOSSYPII

G. Maley, G. Plaut, 1959 .

Adenosine triphosphatase and morphological integrity of mitochondria.

G. Maley, D. Johnson, 1957, Biochimica et biophysica acta.

Phosphorylations associated with the oxidation of external reduced diphosphopyridine nucleotide by rat liver mitochondria.

G. Maley, 1957, The Journal of biological chemistry.

Purification and substrate specificity of a T4 phage intron-encoded endonuclease.

G. Maley, F. Maley, A. M. Wang, 1991, Nucleic acids research.

T4-phage deoxycytidylate deaminase is a metalloprotein containing two zinc atoms per subunit.

G. Maley, F. Maley, R. Silversmith, 1993, The Journal of biological chemistry.

In vitro selection of an RNA sequence that interacts with high affinity with thymidylate synthase.

G. Maley, F. Maley, X. Lin, 2000, Nucleic acids research.

Characterization of a specific interaction between Escherichia coli thymidylate synthase and Escherichia coli thymidylate synthase mRNA.

G. Maley, F. Maley, C. Allegra, 1995, Nucleic acids research.

Feedback Control of Purified Deoxycytidylate Deaminase

G. Maley, F. Maley, 1963, Science.

Plastic adaptation toward mutations in proteins: Structural comparison of thymidylate synthases

R. Stroud, K. M. Perry, E. Fauman, 1990, Proteins.

Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug.

G. Maley, L. Hardy, F. Maley, 1999, Biochemistry.

The effect of reducing reagents on binding of thymidylate synthase protein to thymidylate synthase messenger RNA.

G. Maley, F. Maley, C. Allegra, 1994, The Journal of biological chemistry.

The significance of the substrate specificity of T2r+-induced deoxycytidylate deaminase.

G. Maley, F. Maley, 1966, The Journal of biological chemistry.