H. Wiley

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Inferring Reaction Networks using Perturbation Data

Herbert M. Sauro, H. Steven Wiley, Kiri Choi, 2018, bioRxiv.

Parsing ERK Activation Reveals Quantitatively Equivalent Contributions from Epidermal Growth Factor Receptor and HER2 in Human Mammary Epithelial Cells*

D. Lauffenburger, H. Wiley, B. Hendriks, 2005, Journal of Biological Chemistry.

Generating Synthetic Signaling Networks for in Silico Modeling Studies

Herbert M. Sauro, Jin Xu, H. Steven Wiley, 2020, bioRxiv.

Computational modeling of the EGF-receptor system: a paradigm for systems biology.

D. Lauffenburger, S. Shvartsman, H. Wiley, 2003, Trends in cell biology.

Escape of autocrine ligands into extracellular medium: experimental test of theoretical model predictions.

D. Lauffenburger, H. Wiley, G. Oehrtman, 1998, Biotechnology and bioengineering.

Autocrine loops with positive feedback enable context-dependent cell signaling.

D. Lauffenburger, S. Shvartsman, H. Wiley, 2002, American journal of physiology. Cell physiology.

Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor.

D. Lauffenburger, H. Wiley, R. Coffey, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Open questions: The disrupted circuitry of the cancer cell

H. Wiley, 2014, BMC Biology.

Self-organization of polarized cell signaling via autocrine circuits: computational model analysis.

D. Lauffenburger, H. Wiley, I. Maly, 2004, Biophysical journal.

Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library

H. Steven Wiley, Jennifer R. Cochran, James R. Coleman, 2003, Nature Biotechnology.

Effect of Epidermal Growth Factor Receptor Internalization on Regulation of the Phospholipase C-γ1 Signaling Pathway*

Alan Wells, H. Steven Wiley, Douglas A. Lauffenburger, 1999, The Journal of Biological Chemistry.

An integrated model of epidermal growth factor receptor trafficking and signal transduction.

H. Wiley, H. Resat, D. Dixon, 2003, Biophysical journal.

Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis

H. Wiley, R. Coffey, C. Hawkey, 1999, British Journal of Cancer.

The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor.

D A Lauffenburger, D. Lauffenburger, H. Wiley, 1991, The Journal of biological chemistry.

Trafficking of the ErbB receptors and its influence on signaling.

H Steven Wiley, H. Wiley, 2003, Experimental cell research.

Rapid and sustained nuclear–cytoplasmic ERK oscillations induced by epidermal growth factor

Haluk Resat, Harish Shankaran, H Steven Wiley, 2009, Molecular systems biology.

Ratiometric assay of epidermal growth factor receptor tyrosine kinase activation.

H. Wiley, K. Schooler, 2000, Analytical biochemistry.

Quantitative Analysis of HER2-mediated Effects on HER2 and Epidermal Growth Factor Receptor Endocytosis

D. Lauffenburger, H. Wiley, B. Hendriks, 2003, Journal of Biological Chemistry.

Enabling high-throughput data management for systems biology: The Bioinformatics Resource Manager

Mudita Singhal, Eric G. Stephan, H. Steven Wiley, 2007, Bioinform..

Induced Autocrine Signaling through the Epidermal Growth Factor Receptor Contributes to the Response of Mammary Epithelial Cells to Tumor Necrosis Factor α*

Richard C Zangar, Brian D Thrall, H Steven Wiley, 2004, Journal of Biological Chemistry.

A systems perspective of heterocellular signaling.

H. Wiley, A. Wells, 2018, Essays in biochemistry.

Engineering dynamics of growth factors and other therapeutic ligands.

D. Lauffenburger, H. Wiley, A. Wells, 1996, Biotechnology and bioengineering.

Molecular/cell engineering approach to autocrine ligand control of cell function

D. Lauffenburger, H. Wiley, K. E. Forsten, 1995, Annals of Biomedical Engineering.

Affinity regulates spatial range of EGF receptor autocrine ligand binding.

D. Lauffenburger, H. Wiley, Tomoko Iida, 2002, Developmental biology.

Studies on engineered autocrine systems: requirements for ligand release from cells producing an artificial growth factor.

D. Lauffenburger, H. Wiley, B. Will, 1995, Tissue engineering.

The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis.

H. Wiley, D. Cunningham, Dennis Cunningham, 1982, The Journal of biological chemistry.

Engineering Growth Factor/Receptor Processes: Effects of EGF Receptor Trafficking Dynamics on Cell Proliferation Responses To EGF

D. Lauffenburger, H. Wiley, C. Starburck, 1993 .

Functional reconstitutional of the human epidermal growth factor receptor system in Xenopus oocytes

H. Wiley, L. Opresko, 1990, The Journal of cell biology.

Altered degradation of epidermal growth factor in a diphtheria toxin‐resistant clone of KB cells

H. Wiley, T. Moehring, H. Haigler, 1985, Journal of cellular physiology.

Phenylarsine oxide-induced increase in alveolar macrophage surface receptors: evidence for fusion of internal receptor pools with the cell surface

H. Wiley, J. Kaplan, D. Ward, 1985, The Journal of cell biology.

Genomes to Life "Center for Molecular and Cellular Systems": a research program for identification and characterization of protein complexes.

Malin M. Young, Richard D. Smith, H. Wiley, 2002, Omics : a journal of integrative biology.

Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells.

Lily A. Chylek, Miles A. Miller, Jeremy L. Muhlich, 2020, Cell systems.

Specific factors are required for kinase-dependent endocytosis of insulin receptors.

J. Welsh, H. Wiley, G. Gill, 1994, Molecular biology of the cell.

Assay of growth factor stimulation of fluid-phase endocytosis.

H. Wiley, D. McKinley, 1987, Methods in enzymology.

Differential signaling and regulation of apical vs. basolateral EGFR in polarized epithelial cells.

H. Wiley, L. Opresko, K. Amsler, 1998, American journal of physiology. Cell physiology.

Receptor-Mediated Endocytosis in Xenopus Oocytes

H. Wiley, L. Opresko, I. Characterization, 1987 .

Ligand-induced endocytosis of epidermal growth factor receptors that are defective in binding adaptor proteins.

H. Wiley, G. Gill, A. Nesterov, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Quantitative assessment of autocrine cell loops.

D. Lauffenburger, H. Wiley, G. Oehrtman, 1999, Methods in molecular medicine.

Decoding Signal Processing at the Single-Cell Level.

H Steven Wiley, H. Wiley, 2017, Cell systems.

Cell Surface Receptors for Signal Transduction and Ligand Transport: A Design Principles Study

H. Steven Wiley, Haluk Resat, Harish Shankaran, 2007, PLoS Comput. Biol..

Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system

H. Wiley, H S Wiley, 1988, The Journal of cell biology.

A steady state model for analyzing the cellular binding, internalization and degradation of polypeptide ligands

H. Steven Wiley, Dennis D. Cunningham, H. Wiley, 1981, Cell.

Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo

H. Wiley, J. Segall, P. Kenny, 2013, Oncogene.

Bmc Cell Biology Her/erbb Receptor Interactions and Signaling Patterns in Human Mammary Epithelial Cells

Haluk Resat, Harish Shankaran, H Steven Wiley, 2009 .

Androgens regulate proliferation of human prostate cancer cells in culture by increasing transforming growth factor-alpha (TGF-alpha) and epidermal growth factor (EGF)/TGF-alpha receptor.

H. Wiley, A. Meikle, H S Wiley, 1993, The Journal of clinical endocrinology and metabolism.

Cholesterol dictates the freedom of EGF receptors and HER2 in the plane of the membrane.

H. Wiley, S. Colson, L. Opresko, 2005, Biophysical journal.

The Enhanced Tumorigenic Activity of a Mutant Epidermal Growth Factor Receptor Common in Human Cancers Is Mediated by Threshold Levels of Constitutive Tyrosine Phosphorylation and Unattenuated Signaling*

H. Wiley, W. Cavenee, M. Nagane, 1997, The Journal of Biological Chemistry.

Endocytosis and Lysosomal Targeting of Epidermal Growth Factor Receptors Are Mediated by Distinct Sequences Independent of the Tyrosine Kinase Domain (*)

H. Wiley, L. Opresko, H S Wiley, 1995, The Journal of Biological Chemistry.

Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation

G. M. Walton, J. Welsh, H. Wiley, 1989, Cell.

EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation

Alan Wells, Douglas A Lauffenburger, H Steven Wiley, 2007, Journal of Cell Science.

Coregulation of epidermal growth factor receptor/human epidermal growth factor receptor 2 (HER2) levels and locations: quantitative analysis of HER2 overexpression effects.

Douglas Lauffenburger, H Steven Wiley, Lee K Opresko, 2003, Cancer research.

Trafficking and Proteolytic Release of Epidermal Growth Factor Receptor Ligands Are Modulated by Their Membrane-anchoring Domains*

H. Wiley, Jianying Dong, H. Wiley, 2000, The Journal of Biological Chemistry.

Removal of the Membrane-anchoring Domain of Epidermal Growth Factor Leads to Intracrine Signaling and Disruption of Mammary Epithelial Cell Organization

D. Lauffenburger, H. Wiley, L. Opresko, 1998, The Journal of cell biology.

Genetically modified skin to treat disease: potential and limitations.

H. Wiley, S. Boyce, M. Kwan, 1994, The Journal of investigative dermatology.

Structural and functional characterization of the human gene for sorting nexin 1 (SNX1).

H. Wiley, R. Kurten, B. Shank, 2001, DNA and cell biology.

Modeling the effects of HER/ErbB1-3 coexpression on receptor dimerization and biological response.

Haluk Resat, Harish Shankaran, H Steven Wiley, 2006, Biophysical journal.

Epidermal growth factor receptor signaling in tissues

D. Lauffenburger, S. Shvartsman, H. Wiley, 2004, IEEE Control Systems.

Spatial range of autocrine signaling: modeling and computational analysis.

D A Lauffenburger, D. Lauffenburger, S. Shvartsman, 2001, Biophysical journal.

Multiple Mechanisms Are Responsible for Transactivation of the Epidermal Growth Factor Receptor in Mammary Epithelial Cells*

H. Wiley, R. Coffey, L. Opresko, 2008, Journal of Biological Chemistry.

Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context.

D. Lauffenburger, H. Wiley, H. Shankaran, 2010, Molecular bioSystems.

Endocytic Relay as a Potential Means for Enhancing Ligand Transport through Cellular Tissue Matrices: Analysis and Possible Implications for Drug Delivery.

D. Lauffenburger, H. Wiley, L. Chu, 1996, Tissue engineering.

Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking.

H. Wiley, K. Schooler, P Burke, 2001, Molecular biology of the cell.

Receptor-mediated endocytosis in Xenopus oocytes. I. Characterization of the vitellogenin receptor system.

H. Wiley, L. Opresko, H S Wiley, 1987, The Journal of biological chemistry.

Basic fibroblast growth factor regulates persistent ERK oscillations in premalignant but not malignant JB6 cells.

Harish Shankaran, H Steven Wiley, Lee K Opresko, 2010, The Journal of investigative dermatology.

Highly polarized EGF receptor tyrosine kinase activity initiates egg activation in Xenopus.

H. Wiley, L. Opresko, R. Nuccitelli, 1994, Developmental biology.

An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.

Richard D. Smith, H. Wiley, D. Camp, 2009, Journal of proteome research.

Implications of epidermal growth factor (EGF) induced egf receptor aggregation.

K Lund, H. Wiley, B. Goldstein, 1992, Biophysical journal.

The heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact and prevents HB-EGF proteolytic release

Richard T. Lee, D. Lauffenburger, E. Schreiter, 2010, Journal of Cell Science.

ErbB-2 Amplification Inhibits Down-regulation and Induces Constitutive Activation of Both ErbB-2 and Epidermal Growth Factor Receptors*

H. Wiley, L. Opresko, H S Wiley, 1999, The Journal of Biological Chemistry.

Relationship between epidermal growth factor receptor occupancy and mitogenic response. Quantitative analysis using a steady state model system.

H. Wiley, H S Wiley, D J Knauer, 1984, The Journal of biological chemistry.

How low can you go?

H Steven Wiley, H. Wiley, 2018, eLife.

The membrane-anchoring domain of epidermal growth factor receptor ligands dictates their ability to operate in juxtacrine mode.

D. Lauffenburger, H. Wiley, L. Opresko, 2005, Molecular biology of the cell.

Ligand-induced transformation by a noninternalizing epidermal growth factor receptor.

J. Welsh, H. Wiley, M. Rosenfeld, 1990, Science.

The Membrane-anchoring Domain of EGF Receptor Ligands Dictates Their Ability to Operate in Juxtacrine Mode

D. Lauffenburger, H. Wiley, L. Opresko, 2005 .

Internalized Epidermal Growth Factor Receptors Participate in the Activation of p21 ras in Fibroblasts*

D. Lauffenburger, H. Wiley, J. Haugh, 1999, The Journal of Biological Chemistry.

Quantitative analysis of the EGF receptor autocrine system reveals cryptic regulation of cell response by ligand capture.

D A Lauffenburger, D. Lauffenburger, H. Wiley, 2001, Journal of cell science.

Human mammary epithelial cells rapidly exchange empty EGFR between surface and intracellular pools

H. Wiley, H S Wiley, P M Burke, 1999, Journal of cellular physiology.

The dynamic expression of the epidermal growth factor receptor and epidermal growth factor ligand family in a differentiating intestinal epithelial cell line.

H. Wiley, R. Coffey, P. Dempsey, 1999, Growth factors.

Real-time quantitative measurement of autocrine ligand binding indicates that autocrine loops are spatially localized.

D A Lauffenburger, D. Lauffenburger, H. Wiley, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Structural Aspects of the Epidermal Growth Factor Receptor Required for Transmodulation of erbB-2/neu*

H. Wiley, R. Worthylake, Rebecca Worthylake, 1997, The Journal of Biological Chemistry.

Quantitative Analysis of HER2-mediated Effects on HER2 and Epidermal Growth Factor Receptor Endocytosis

D. Lauffenburger, H. Wiley, B. Hendriks, 2003, Journal of Biological Chemistry.

Engineering epidermal growth factor for enhanced mitogenic potency

Alan Wells, H. Steven Wiley, Douglas A. Lauffenburger, 1996, Nature Biotechnology.

Dynamics and Sensitivity of Signaling Pathways

Michael A. Kochen, H. Sauro, S. Andrews, 2021, Current Pathobiology Reports.

Quantitative analysis of the endocytic system involved in hormone-induced receptor internalization.

H. Wiley, L. Opresko, C. Starbuck, 1990, The Journal of biological chemistry.

The mammary epithelial cell secretome and its regulation by signal transduction pathways.

David G Camp, Brian D Thrall, Jon M Jacobs, 2008, Journal of proteome research.

Regulation of postendocytic trafficking of the epidermal growth factor receptor through endosomal retention.

D. Lauffenburger, H. Wiley, L. Opresko, 1994, The Journal of biological chemistry.

Photoaffinity labeling of specific alpha-thrombin binding sites on Chinese hamster lung cells.

H. Wiley, J. Fenton, D. Cunningham, 1983, The Journal of biological chemistry.

Ligand-induced internalization and increased cell calcium are mediated via distinct structural elements in the carboxyl terminus of the epidermal growth factor receptor.

J. Kao, H. Wiley, M. Rosenfeld, 1991, The Journal of biological chemistry.

Epidermal growth factor rapidly induces a redistribution of transferrin receptor pools in human fibroblasts.

H. Wiley, J. Kaplan, H S Wiley, 1984, Proceedings of the National Academy of Sciences of the United States of America.

HER2-mediated effects on EGFR endosomal sorting: analysis of biophysical mechanisms.

Douglas Lauffenburger, H Steven Wiley, D. Lauffenburger, 2003, Biophysical journal.

Epidermal growth factor binding and trafficking dynamics in fibroblasts: relationship to cell proliferation

D. Lauffenburger, H. Wiley, C. Starbuck, 1990 .

Chapter 9 Receptors as Models for the Mechanisms of Membrane Protein Turnover and Dynamics

H. Wiley, 1985 .

Epidermal growth factor stimulates fluid phase endocytosis in human fibroblasts through a signal generated at the cell surface

H. Wiley, D. Cunningham, 1982, Journal of cellular biochemistry.

Receptor-mediated endocytosis in Xenopus oocytes. II. Evidence for two novel mechanisms of hormonal regulation.

H. Wiley, L. Opresko, H S Wiley, 1987, The Journal of biological chemistry.

Receptor downregulation and desensitization enhance the information processing ability of signalling receptors

H. Steven Wiley, Haluk Resat, Harish Shankaran, 2007, BMC Syst. Biol..

Phosphorylation of the epidermal growth factor receptor at threonine 654 inhibits ligand-induced internalization and down-regulation.

G. M. Walton, J. Welsh, H. Wiley, 1990, Journal of Biological Chemistry.

Global modulation of the epidermal growth factor receptor is triggered by occupancy of only a few receptors. Evidence for a binary regulatory system in normal human fibroblasts.

H. Wiley, B. Walsh, K. Lund, 1989, The Journal of biological chemistry.

Autocrine epidermal growth factor signaling stimulates directionally persistent mammary epithelial cell migration

D. Lauffenburger, H. Wiley, G. Maheshwari, 2001, The Journal of cell biology.

Mutational removal of the Thr669 and Ser671 phosphorylation sites alters substrate specificity and ligand-induced internalization of the epidermal growth factor receptor.

H. Wiley, H. Ingraham, G. Heisermann, 1990, The Journal of biological chemistry.

Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions.

D A Lauffenburger, D. Lauffenburger, H. Wiley, 1994, The Journal of biological chemistry.

Achieving Molecular Selectivity in Imaging Using Multiphoton Raman Spectroscopy Techniques

G R Holtom, S D Colson, H. Wiley, 2001, Traffic.

Open questions: The disrupted circuitry of the cancer cell

H. Wiley, 2014, BMC Biology.

Intracellular processing of epidermal growth factor and its effect on ligand-receptor interactions.

H. Wiley, H S Wiley, D D Cunningham, 1985, The Journal of biological chemistry.

FRET measurements between small numbers of molecules identifies subtle changes in receptor interactions

H. Steven Wiley, Haluk Resat, Steven D. Colson, 2004, SPIE BiOS.

Generating synthetic signaling networks for in silico modeling studies

H. Sauro, H. Wiley, Jin Xu, 2020, bioRxiv.

Integrating Multiple Types of Data for Signaling Research: Challenges and Opportunities

H Steven Wiley, H. Wiley, 2011, Science Signaling.

Integrated experimental and model-based analysis reveals the spatial aspects of EGFR activation dynamics.

Haluk Resat, Yi Zhang, Harish Shankaran, 2012, Molecular bioSystems.

3-D multispectral monitoring of living cell signaling using confocal imaging and FPGA processing

Scott E. Budge, Kenneth Perrine, Marianne Sowa Resat, 2004, 2004 2nd IEEE International Symposium on Biomedical Imaging: Nano to Macro (IEEE Cat No. 04EX821).

A Model of Cytokine Shedding Induced by Low Doses of Gamma Radiation

J. Miller, H. Wiley, S. Jin, 2005, Radiation research.

Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway.

D A Lauffenburger, D. Lauffenburger, H. Wiley, 1999, The Journal of biological chemistry.

HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells

H. Wiley, H. Shankaran, L. Opresko, 2009, BMC Cell Biology.

Ligand accumulation in autocrine cell cultures.

Douglas A Lauffenburger, Stanislav Y Shvartsman, H Steven Wiley, 2005, Biophysical journal.

Should software hold data hostage?

George S. Michaels, H Steven Wiley, H. Wiley, 2004, Nature Biotechnology.