M. Vieth

发表

Kinomics-structural biology and chemogenomics of kinase inhibitors and targets.

M. Vieth, R. Higgs, D. Robertson, 2004, Biochimica et biophysica acta.

Kinomics: characterizing the therapeutically validated kinase space.

M. Vieth, D. Robertson, J. Sutherland, 2005, Drug discovery today.

Characteristic physical properties and structural fragments of marketed oral drugs.

Ian A. Watson, M. Vieth, R. Higgs, 2004, Journal of medicinal chemistry.

The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines.

S. A. Watkins, M. Vieth, R. Campbell, 2004, Molecular cancer therapeutics.

Aminoimidazo[1,2-a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation.

S. A. Watkins, M. Vieth, R. Campbell, 2004, Bioorganic & medicinal chemistry letters.

Predicting the Conformational Variability of Abl Tyrosine Kinase using Molecular Dynamics Simulations and Markov State Models.

M. Vieth, B. Roux, D. Clawson, 2018, Journal of chemical theory and computation.

Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.

M. Vieth, R. Campbell, B. Anderson, 2003, Journal of medicinal chemistry.

Chemical fragments as foundations for understanding target space and activity prediction.

Ian A. Watson, M. Vieth, R. Higgs, 2008, Journal of medicinal chemistry.

Kinase inhibitor data modeling and de novo inhibitor design with fragment approaches.

Ian A. Watson, M. Vieth, R. Higgs, 2009, Journal of medicinal chemistry.

Lessons in molecular recognition: the effects of ligand and protein flexibility on molecular docking accuracy.

Richard A. Lewis, M. Vieth, D. Robertson, 2004, Journal of medicinal chemistry.

Do active site conformations of small ligands correspond to low free-energy solution structures?

C L Brooks, J D Hirst, C. Brooks, 1998, Journal of computer-aided molecular design.

Prediction of protein secondary structure by neural networks: encoding short and long range patterns of amino acid packing.

J Skolnick, A Koliński, J. Skolnick, 1992, Acta biochimica Polonica.

Drugs in other drugs: a new look at drugs as fragments.

Michal Vieth, M. Vieth, M. Siegel, 2007, Drug discovery today.

DoMCoSAR: a novel approach for establishing the docking mode that is consistent with the structure-activity relationship. Application to HIV-1 protease inhibitors and VEGF receptor tyrosine kinase inhibitors.

M. Vieth, D. Cummins, Michal Vieth, 2000, Journal of medicinal chemistry.

Dependence of molecular properties on proteomic family for marketed oral drugs.

Michal Vieth, Jeffrey J Sutherland, M. Vieth, 2006, Journal of medicinal chemistry.

Prediction of the folding pathways and structure of the GCN4 leucine zipper.

A Kolinski, J Skolnick, C L Brooks, 1994, Journal of molecular biology.

Reconstruction of 3D structures of MET antibodies from electron microscopy 2D class averages

Ilan E. Chemmama, A. Sali, D. Schneidman-Duhovny, 2017, PloS one.

Assessing energy functions for flexible docking

Charles L. Brooks, Jonathan D. Hirst, Michal Vieth, 1998, J. Comput. Chem..

Perspective on computational and structural aspects of kinase discovery from IPK2014.

S. Knapp, M. Vieth, J. Meiler, 2015, Biochimica et biophysica acta.

A High-Throughput Screen against Pantothenate Synthetase (PanC) Identifies 3-Biphenyl-4-Cyanopyrrole-2-Carboxylic Acids as a New Class of Inhibitor with Activity against Mycobacterium tuberculosis

D. Sherman, M. Vieth, P. Hipskind, 2013, PloS one.

Identification of tyrosine kinase inhibitors that halt Plasmodium falciparum parasitemia

P. Low, M. Vieth, P. Hipskind, 2020, PloS one.

Method for predicting the state of association of discretized protein models. Application to leucine zippers.

A Kolinski, J Skolnick, J. Skolnick, 1996, Biochemistry.

Molecular Basis for Necitumumab Inhibition of EGFR Variants Associated with Acquired Cetuximab Resistance

J. Haidar, M. Vieth, S. Eastman, 2017, Molecular Cancer Therapeutics.

Selectivity data: assessment, predictions, concordance, and implications.

Ian A. Watson, M. Vieth, P. Iversen, 2013, Journal of medicinal chemistry.

Dynamic Error Correction in Autocatalytic Peptide Networks

Kay Severin, M. Vieth, M. Ghadiri, 1998 .

Detailed analysis of grid‐based molecular docking: A case study of CDOCKER—A CHARMm‐based MD docking algorithm

Charles L. Brooks, Guosheng Wu, Michal Vieth, 2003, J. Comput. Chem..

Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions

Robert H Bates, M. Vieth, P. Hipskind, 2022, ACS infectious diseases.

Discovery of selective RIO2 kinase small molecule ligand.

M. Vieth, David A. Evans, Thibault Varin, 2015, Biochimica et biophysica acta.

Novel route to the synthesis of 4-quinolyl isothiocyanates

M. Vieth, C. Hamdouchi, R. Al-awar, 2006 .

Crystal structure of human RIOK2 bound to a specific inhibitor

M. Vieth, J. Elkins, Thibault Varin, 2019, Open Biology.

Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis

M. Vieth, M. Files, T. Parish, 2016, Antimicrobial Agents and Chemotherapy.

Structural determinants of dual incretin receptor agonism by tirzepatide

M. Vieth, T. S. Kobilka, B. Kobilka, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Molecular properties that influence oral drug-like behavior.

Michael S Lajiness, Michal Vieth, Jon Erickson, 2004, Current opinion in drug discovery & development.

What general conclusions can we draw from kinase profiling data sets?

Michal Vieth, Cen Gao, Jeffrey J Sutherland, 2013, Biochimica et biophysica acta.

Assessing search strategies for flexible docking

Charles L. Brooks, Jonathan D. Hirst, Michal Vieth, 1998, J. Comput. Chem..

Structural insights into probe-dependent positive allosterism of the GLP-1 receptor

M. Vieth, B. Chau, T. S. Kobilka, 2020, Nature Chemical Biology.

Lessons in Molecular Recognition, 2. Assessing and Improving Cross-Docking Accuracy

Michal Vieth, Jeffrey J. Sutherland, Ravi Nandigam, 2007, J. Chem. Inf. Model..

P110 Identification of the tryptophan metabolite 3-hydroxyanthranilic acid as a novel tool for the differentiation of Crohn’s disease phenotypes

M. Vieth, J. Pfeilschifter, J. Stein, 2020 .

Prediction of quaternary structure of coiled coils. Application to mutants of the GCN4 leucine zipper.

J. Skolnick, A. Kolinski, C. Brooks, 1995, Journal of molecular biology.

Prediction of protein secondary structure by an enhanced neural network.

M Vieth, A Koliński, A. Kolinski, 1991, Acta biochimica Polonica.

Structure-guided expansion of kinase fragment libraries driven by support vector machine models.

Michal Vieth, Ian A. Watson, Richard E Higgs, 2010, Biochimica et biophysica acta.

COMBINING MEDICINAL CHEMISTRY WITH CHEMOGENOMIC AND COMPUTER-AIDED STRUCTURE-BASED DESIGN IN DEVELOPMENT OF NOVEL KINASE INHIBITORS

M. Vieth, C. Hamdouchi, Faming Zhang, 2003 .

Knowledge-Based Strategy to Improve Ligand Pose Prediction Accuracy for Lead Optimization

Ji-Bo Wang, Michal Vieth, Cen Gao, 2015, J. Chem. Inf. Model..