D. Spring

发表

Chemical Genetics to Chemical Genomics: Small Molecules Offer Big Insights

D. Spring, 2005 .

Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips.

S. Haggarty, S. Schreiber, M. Snyder, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions

D. Spring, N. Robertson, D. R. Spring, 2018, Molecules.

Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions

D. Spring, G. McKenzie, A. Venkitaraman, 2015, Chemistry & biology.

A one-bead, one-stock solution approach to chemical genetics: part 2.

P. Clemons, D. Spring, M. Foley, 2001, Chemistry & biology.

Chemogenomics approaches for receptor deorphanization and extensions of the chemogenomics concept to phenotypic space.

John P. Overington, Julio E. Peironcely, H. V. van Vlijmen, 2011, Current topics in medicinal chemistry.

Assessment of structural diversity in combinatorial synthesis.

A. Bender, D. Spring, S. Fergus, 2005, Current opinion in chemical biology.

Diversity-oriented synthesis of macrocyclic peptidomimetics

A. Bender, D. Spring, M. Welch, 2011, Proceedings of the National Academy of Sciences.

Peptide stapling techniques based on different macrocyclisation chemistries.

D. Spring, Peterson de Andrade, Y. H. Lau, 2015, Chemical Society reviews.

Diversity-oriented synthesis; a spectrum of approaches and results.

Andreas Bender, David R Spring, A. Bender, 2008, Organic & biomolecular chemistry.

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.

David R Spring, Warren R J D Galloway, D. Spring, 2010, Nature communications.

Drug discovery: A question of library design

Warren R. J. D. Galloway, David R. Spring, Philip J. Hajduk, 2011, Nature.

A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling.

David R Spring, Yaw Sing Tan, Feilin Nie, 2013, Nature chemistry.

Diversity-oriented synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with α-iminocarbenes

D. Spring, Alejandro Guarnieri-Ibáñez, Florian Medina, 2017, Chemical science.

Diversity-oriented synthesis of macrocyclic

Andreas Bender, Warren R. J. D. Galloway, David R. Spring, 2011 .

Diversity-oriented synthesis; a challenge for synthetic chemists.

David R Spring, D. Spring, D. R. Spring, 2003, Organic & biomolecular chemistry.

Chemical genetics to chemical genomics: small molecules offer big insights.

David R Spring, D. Spring, D. R. Spring, 2005, Chemical Society reviews.

Anti-MRSA agent discovery using diversity-oriented synthesis.

Andreas Bender, David R Spring, Martin Welch, 2008, Angewandte Chemie.

Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.

David R Spring, Martin Welch, Warren R J D Galloway, 2008, Chemical communications.

Synthesis of unprecedented scaffold diversity.

David R Spring, Warren R J D Galloway, D. Spring, 2009, Angewandte Chemie.

Skeletal diversity construction via a branching synthetic strategy.

Suzanne Fergus, Andreas Bender, David R Spring, 2006, Chemical communications.

Diversity-oriented synthesis: producing chemical tools for dissecting biology.

David R Spring, D. Spring, Henning S. g. Beckmann, 2012, Chemical Society reviews.

Exploiting domino enyne metathesis mechanisms for skeletal diversity generation.

David R Spring, D. Spring, Richard J Spandl, 2008, Chemical communications.

Diversity-oriented synthesis of bicyclic and tricyclic alkaloids.

Kieron M. G. O'Connell, D. Spring, W. R. Galloway, 2010, Chemical communications.

Synthesis of Unprecedented Scaffold Diversity

D. Spring, W. R. Galloway, Albert Isidro-Llobet, 2009 .

Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1

Chris Abell, Robert B Best, David R Spring, 2012, Angewandte Chemie.

An Introduction to Diversity‐Oriented Synthesis

Kieron M. G. O'Connell, D. Spring, R. J. Spandl, 2009 .

C-H activation: Complex peptides made simple.

D. Spring, S. Bartlett, 2016, Nature chemistry.

Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment‐Based Drug Discovery

D. Spring, T. A. King, H. Stewart, 2019, European journal of organic chemistry.

Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen.

D. Spring, W. R. Galloway, S. Bartlett, 2016, Organic and biomolecular chemistry.

The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein-Protein Interactions.

D. Spring, Y. S. Tan, C. Verma, 2015, Journal of chemical theory and computation.

Diversity‐Oriented Synthesis

Kieron M. G. O'Connell, D. Spring, R. J. Spandl, 2009 .

The Basics of Diversity‐Oriented Synthesis

Warren R. J. D. Galloway, David R. Spring, Kieron M. G. O'Connell, 2013 .

Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics

Stephen J. Walsh, J. Carroll, D. Spring, 2020, Angewandte Chemie.

The molecular basis of the host response to lipopolysaccharide

D. Spring, N. Gay, C. Bryant, 2010, Nature Reviews Microbiology.

Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer

J. Brenton, D. Spring, L. Itzhaki, 2016, Angewandte Chemie.

Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery.

D. Spring, S. L. Kidd, Kim T Mortensen, 2020, Chemical communications.

Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction

Matthew N. Grayson, D. Spring, L. Itzhaki, 2020, ACS omega.

Induction-driven stabilization of the anion-π interaction in electron-rich aromatics as the key to fluoride inclusion in imidazolium-cage receptors.

Kwang S. Kim, Kwang Soo Kim, D. Spring, 2011, Chemistry.

Palladium-catalysed cross-coupling of vinyldisiloxanes with benzylic and allylic halides and sulfonates.

D. Spring, A. Venkitaraman, D. G. Hulcoop, 2012, Chemistry.

Synthesis of Structurally Diverse N‐Substituted Quaternary‐Carbon‐Containing Small Molecules from α,α‐Disubstituted Propargyl Amino Esters

Andreas Bender, David R Spring, Leen Kalash, 2018, Chemistry.

C(sp3)-H arylation to construct all-syn cyclobutane-based heterobicyclic systems: a novel fragment collection.

D. Spring, S. L. Kidd, T. A. King, 2020, Chemical communications.

Site-selective modification strategies in antibody-drug conjugates.

Stephen J. Walsh, J. Carroll, D. Spring, 2020, Chemical Society reviews.

Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates

Stephen J. Walsh, J. Carroll, D. Spring, 2018, Chemical science.

Rapid and robust cysteine bioconjugation with vinylheteroarenes†

Stephen J. Walsh, J. Carroll, D. Spring, 2021, Chemical science.

Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc00798a

D. Spring, Y. S. Tan, C. Verma, 2019, Chemical science.

Formation of flavone-based wooly fibres by glandular trichomes of Dionysia tapetodes

D. Spring, R. Wightman, Karin H. Müller, 2020, bioRxiv.

Discovery of a highly selective turn-on fluorescent probe for Ag+.

D. Spring, Juyoung Yoon, Zhaochao Xu, 2010, The Analyst.

Antiplasmodial and trypanocidal activity of violacein and deoxyviolacein produced from synthetic operons

S. Oliver, J. Ajioka, D. Spring, 2018, BMC Biotechnology.

GLP-1R is downregulated in beta cells of NOD mice and T1D patients

J. Hecksher-Sørensen, D. Spring, G. Ladds, 2019, bioRxiv.

Diversity-Oriented Synthesis: Producing Chemical Tools for Dissecting Biology

David R. Spring, D. Spring, Henning S. g. Beckmann, 2012 .

Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa.

A. Poso, D. Spring, M. Welch, 2017, Biochemistry.

A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation

Jamie E. Stokes, D. Spring, G. McKenzie, 2019, Scientific Reports.

Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis.

Jamie E. Stokes, D. Spring, W. R. Galloway, 2015, Bioorganic & medicinal chemistry.

New Advances in Diversity‐Oriented Synthesis

Jamie E. Stokes, D. Spring, W. R. Galloway, 2015 .

A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds.

Kieron M. G. O'Connell, A. Bender, D. Spring, 2012, Organic & biomolecular chemistry.

A concise total synthesis of deoxyschizandrin and exploration of its antiproliferative effects and those of structurally related derivatives.

D. Spring, Luca Laraia, W. R. Galloway, 2012, Chemistry.

Divergent Synthesis of Novel Cylindrocyclophanes that Inhibit Methicillin‐Resistant Staphylococcus aureus (MRSA)

D. Spring, M. Welch, N. Robertson, 2020, ChemMedChem.

Diversity-oriented synthesis of drug-like macrocyclic scaffolds using an orthogonal organo- and metal catalysis strategy.

D. Spring, J. Hodgkinson, André Grossmann, 2014, Angewandte Chemie.

Diversity-Oriented Synthesis of Macrocycle Libraries for Drug Discovery and Chemical Biology

D. Spring, Feilin Nie, S. Bartlett, 2016, Synthesis.

Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase–TPX2 protein–protein interaction

W. L. Jorgensen, D. Spring, G. McKenzie, 2017, Chemical communications.

Assessment of Structural Diversity in Combinatorial Synthesis

A. Bender, D. Spring, S. Fergus, 2005 .

Diversity‐Oriented Synthesis of Biaryl‐Containing Medium Rings Using a One Bead/One Stock Solution Platform.

S. Schreiber, D. Spring, H. Blackwell, 2002 .

Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.

D. Spring, A. C. Simon, L. Pellegrini, 2017, Angewandte Chemie.

Linear Aliphatic Dialkynes as Alternative Linkers for Double‐Click Stapling of p53‐Derived Peptides

D. Spring, G. McKenzie, Peterson de Andrade, 2014, Chembiochem : a European journal of chemical biology.

Small-molecule screening: advances in microarraying and cell-imaging technologies.

D. Spring, M. Welch, M. Ladlow, 2007, ACS chemical biology.

Fluorescent chemosensors for Zn(2+).

D. Spring, Juyoung Yoon, Zhaochao Xu, 2010, Chemical Society reviews.

The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions

D. Spring, B. Gan, Josephine Gaynord, 2021, Chemical Society reviews.

Semi-syntheses of the 11-hydroxyrotenoids sumatrol and villosinol.

D. Spring, D. Russell, A. Bond, 2018, Organic & biomolecular chemistry.

The Synthesis of Quinolone Natural Products from Pseudonocardia sp.

D. Spring, M. Welch, W. R. Galloway, 2015, European Journal of Organic Chemistry.

Palladium-catalysed cross-coupling of organosilicon reagents.

D. Spring, W. R. Galloway, H. Sore, 2012, Chemical Society reviews.

Combinatorial Synthesis of Structurally Diverse Triazole-Bridged Flavonoid Dimers and Trimers

D. Spring, F. Hollfelder, W. R. Galloway, 2016, Molecules.

Synthesis of structurally diverse biflavonoids

D. Spring, W. R. Galloway, J. Ciardiello, 2018, Tetrahedron.

Divergent and concise total syntheses of dihydrochalcones and 5-deoxyflavones recently isolated from Tacca species and Mimosa diplotricha

D. Spring, W. R. Galloway, T. H. Sum, 2015 .

Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity.

D. Spring, Y. S. Tan, A. Venkitaraman, 2012, Organic & biomolecular chemistry.

Cleavable linkers in antibody-drug conjugates.

D. Spring, Albert Isidro-Llobet, Jonathan D Bargh, 2019, Chemical Society reviews.

Dynamic Combinatorial Chemistry with Novel Dithiol Building Blocks: Towards New Structurally Diverse and Adaptive Screening Collections

T. M. Postma, D. Spring, W. R. Galloway, 2013, Synlett.

A selective and ratiometric Cu2+ fluorescent probe based on naphthalimide excimer-monomer switching.

D. Spring, Juyoung Yoon, Zhaochao Xu, 2010, Chemical communications.

Development of off-on fluorescent probes for heavy and transition metal ions.

D. Spring, Juyoung Yoon, Zhaochao Xu, 2010, Chemical communications.

Chemical genetics.

D. Spring, Luca Laraia, C. J. O’Connor, 2011, Chemical Society reviews.

High content screening of diverse compound libraries identifies potent modulators of tubulin dynamics.

David R Spring, Ashok R Venkitaraman, Luca Laraia, 2014, ACS medicinal chemistry letters.

Diversity-oriented synthesis.

David R Spring, Kieron M. G. O'Connell, D. Spring, 2009, Chemical record.

Zn2+-triggered amide tautomerization produces a highly Zn2+-selective, cell-permeable, and ratiometric fluorescent sensor.

D. Spring, Juyoung Yoon, Zhaochao Xu, 2010, Journal of the American Chemical Society.

Fluorescent Chemosensors for Zn2

D. Spring, Juyoung Yoon, Zhaochao Xu, 2010 .

Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria.

D. Spring, M. Welch, W. R. Galloway, 2012, Trends in microbiology.

(Z)-Selective Takai olefination of salicylaldehydes

D. Spring, J. Goodman, W. R. Galloway, 2017, Beilstein journal of organic chemistry.

Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection.

D. Spring, S. L. Kidd, A. North, 2019, Organic letters.

Fluoride-free cross coupling using vinyldisiloxanes.

D. Spring, S. Macdonald, D. Fox, 2009, Organic & biomolecular chemistry.

Synthesis and utilization of functionalized polystyrene resins

D. Spring, M. Ladlow, G. Thomas, 2005 .

Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents.

Stephen J. Walsh, J. Carroll, D. Spring, 2020, Chemical communications.

Photocatalytic methods for amino acid modification.

Stephen J. Walsh, D. Spring, T. A. King, 2020, Chemical Society reviews.

A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates† †Dedicated to Professor Jack Baldwin on the occasion of his 80th birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c

Stephen J. Walsh, J. Carroll, D. Spring, 2018, Chemical science.

Total synthesis of sanguiin H-5.

D. Spring, R. J. Spandl, D. Surry, 2008, Organic letters.

Synthesis of medium-ring and iodinated biaryl compounds by organocuprate oxidation.

D. Spring, Vilius Franckevičius, S. Macdonald, 2005, Angewandte Chemie.

Aryl-aryl bond formation by the fluoride-free cross-coupling of aryldisiloxanes with aryl bromides.

Kieron M. G. O'Connell, D. Spring, D. G. Hulcoop, 2011, Chemistry.

Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2

David R. Spring, Marko Hyvönen, Ashok R. Venkitaraman, 2016, Scientific Reports.

Surface swarming motility by Pectobacterium atrosepticum is a latent phenotype that requires O antigen and is regulated by quorum sensing.

D. Spring, M. Welch, J. Hodgkinson, 2013, Microbiology.

Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides.

D. Spring, G. McKenzie, Peterson de Andrade, 2015, Angewandte Chemie.

Identification of Key Residues That Confer Rhodobacter sphaeroides LPS Activity at Horse TLR4/MD-2

D. Spring, N. Gay, Kate L. Irvine, 2014, PloS one.

Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase

D. Spring, L. Itzhaki, Y. S. Tan, 2017, Journal of the American Chemical Society.

Toxicity of six plant extracts and two pyridone alkaloids from Ricinus communis against the malaria vector Anopheles gambiae

D. Spring, D. Masiga, H. Alborn, 2014, Parasites & Vectors.

Immunomodulatory effects of Pseudomonas aeruginosa quorum sensing small molecule probes on mammalian macrophages.

D. Spring, M. Welch, C. Bryant, 2006, Molecular bioSystems.

Studies on the Biomimetic Synthesis of the Manzamine Alkaloids

D. Spring, T. Claridge, J. Baldwin, 1999 .

Investigations into the Manzamine Alkaloid Biosynthetic Hypothesis.

D. Spring, I. Mutton, T. Claridge, 1998, Angewandte Chemie.

An approach to the manzamine alkaloids modelled on a biogenetic theory

D. Spring, T. Claridge, J. Baldwin, 1997 .

High throughput ‘catch-and-release’ synthesis within spatially discrete gel arrays

D. Spring, H. Sore, David Norton, 2010 .

A two-component 'double-click' approach to peptide stapling

D. Spring, W. R. Galloway, Y. H. Lau, 2015, Nature Protocols.

Functionalised staple linkages for modulating the cellular activity of stapled peptides

D. Spring, L. Itzhaki, D. Lane, 2014 .

Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling.

Stephen J. Walsh, D. Spring, N. Robertson, 2019, Chemical communications.

Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.

Stephen J. Walsh, D. Spring, L. Itzhaki, 2019, Chemical communications.

Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides.

Stephen J. Walsh, D. Spring, L. Itzhaki, 2019, ACS chemical biology.

Investigating peptide sequence variations for 'double-click' stapled p53 peptides.

D. Spring, D. Lane, G. McKenzie, 2014, Organic & biomolecular chemistry.

Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways.

James T Hodgkinson, David R Spring, Martin Welch, 2011, Chemical reviews.

Novel non-ATP competitive small molecules targeting the CK2 α/β interface

D. Spring, M. Hyvönen, A. North, 2018, Bioorganic & medicinal chemistry.

Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study

D. Spring, P. Brear, M. Hyvönen, 2021, Molecules.

Chemical probes targeting the kinase CK2: a journey outside the catalytic box.

D. Spring, P. Brear, M. Hyvönen, 2021, Organic & biomolecular chemistry.

Towards quorum-quenching catalytic antibodies.

D. Spring, M. Welch, M. Ramstedt, 2009, Chemical communications.

Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells.

D. A. Russell, D. Spring, D. Russell, 2020, Journal of natural products.

Stereocontrolled semi-syntheses of deguelin and tephrosin† †Electronic supplementary information (ESI) available: 1H and 13C NMR spectra. See DOI: 10.1039/c6ob02659a Click here for additional data file.

D. Spring, D. Russell, H. Sore, 2017, Organic and biomolecular chemistry.

Vinyldisiloxanes: their synthesis, cross coupling and applications.

D. Spring, Luca Laraia, W. R. Galloway, 2011, Organic & biomolecular chemistry.

Second-generation CK2α inhibitors targeting the αD pocket† †Electronic supplementary information (ESI) available: All experimental details, crystallographic data collection and refinement statistics, details of chemical synthesis, additional figures and tables. See DOI: 10.1039/c7sc05122k

D. Spring, P. Brear, M. Rossmann, 2018, Chemical science.

Combating multidrug-resistant bacteria: current strategies for the discovery of novel antibacterials.

Kieron M. G. O'Connell, D. Spring, M. Welch, 2013, Angewandte Chemie.

Divergent Synthesis of Quinolone Natural Products from Pseudonocardia sp. CL38489

D. Spring, J. Hodgkinson, L. Carro, 2016, European journal of organic chemistry.

The Use of Chlorobenzene as a Probe Molecule in Molecular Dynamics Simulations

David R. Spring, Chris Abell, Chandra Verma, 2014, J. Chem. Inf. Model..

Quantitatively Mapping Cellular Viscosity with Detailed Organelle Information via a Designed PET Fluorescent Probe

D. Spring, Zhaochao Xu, X. Qian, 2014, Scientific Reports.

Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence

J. Brenton, D. Spring, M. Stewart, 2016, Journal of structural biology.

Metabolic and regulatory engineering of Serratia marcescens: mimicking phage-mediated horizontal acquisition of antibiotic biosynthesis and quorum-sensing capacities.

D. Spring, G. Salmond, S. Coulthurst, 2006, Microbiology.

Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site

T. Blundell, P. Simpson, E. Cota, 2011, Structure.

3D small-molecule microarrays.

D. Spring, M. Ladlow, R. L. Nicholson, 2009, Chemical communications.

Multifunctional supramolecular polymer networks as next-generation consolidants for archaeological wood conservation

Alexandros Koutsioubas, Zarah Walsh, Emma-Rose Janeček, 2014, Proceedings of the National Academy of Sciences.

A quorum-sensing molecule acts as a morphogen controlling gas vesicle organelle biogenesis and adaptive flotation in an enterobacterium

D. Spring, G. Salmond, J. Ramsay, 2011, Proceedings of the National Academy of Sciences.

Engineering of new prodigiosin-based biosensors of Serratia for facile detection of short-chain N-acyl homoserine lactone quorum-sensing molecules.

D. Spring, G. Salmond, Timothy M. Carlton, 2010, Environmental microbiology reports.

Energetics of lipid transport by the ABC transporter MsbA is lipid dependent

D. Spring, K. Fukase, Yakun Tang, 2021, Communications Biology.

Development of a Novel Cell-Permeable Protein–Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1

D. Spring, G. McKenzie, A. Venkitaraman, 2019, ACS omega.

How Diverse Are Diversity Assessment Methods? A Comparative Analysis and Benchmarking of Molecular Descriptor Space

Andreas Bender, Alexios Koutsoukas, Shardul Paricharak, 2014, J. Chem. Inf. Model..

Controlling the contents of microdroplets by exploiting the permeability of PDMS.

Santoshkumar N. Patil, James T Hodgkinson, David R Spring, 2011, Lab on a chip.

LGR5 targeting molecules as therapeutic agents for multiple cancer types

Stephen J. Walsh, J. Brenton, D. Spring, 2022, bioRxiv.

Towards Diversity-Oriented, Stereoselective Syntheses of Biaryl- or Bis(aryl)metal-Containing Medium Rings

Stuart L. Schreiber, David R. Spring, Shyam Krishnan, 2000 .

Arene C-H functionalisation using a removable/modifiable or a traceless directing group strategy.

D. Spring, Fengzhi Zhang, D. R. Spring, 2014, Chemical Society reviews.

Concise Synthesis of Substituted Quinolizin‐4‐ones by Ring‐Closing Metathesis

D. Spring, W. R. Galloway, T. Alanine, 2014 .

Concise copper-catalyzed synthesis of tricyclic biaryl ether-linked aza-heterocyclic ring systems.

D. Spring, W. R. Galloway, J. Parker, 2013, Organic letters.

Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction.

D. Spring, L. Itzhaki, M. Hyvönen, 2020, Organic & biomolecular chemistry.

Two‐Component Stapling of Biologically Active and Conformationally Constrained Peptides: Past, Present, and Future

D. Spring, M. Hyvönen, N. Robertson, 2018, Advanced Therapeutics.

Efficient synthesis of the sponge alkaloids cyclostellettamines A-F

D. Spring, J. Baldwin, V. Lee, 1998 .

A novel Diels-Alder approach to hydroisoquinolines

D. Spring, J. Baldwin, R. Whitehead, 1998 .

Synthesis and stability of small molecule probes for Pseudomonas aeruginosa quorum sensing modulation.

D. Spring, M. Welch, G. Salmond, 2004, Organic & biomolecular chemistry.

Enantioselective Synthesis of Chromanones via a Peptidic Phosphane Catalyzed Rauhut-Currier Reaction.

D. Spring, André Grossmann, R. Scanes, 2015, Organic letters.

Diversity-oriented synthesis as a tool for identifying new modulators of mitosis

Brett M. Ibbeson, D. Spring, G. McKenzie, 2014, Nature Communications.

Peptides as a platform for targeted therapeutics for cancer: peptide-drug conjugates (PDCs).

D. Spring, J. Iegre, Daniel H. O’ Donovan, 2020, Chemical Society reviews.

Which microbial factors really are important in Pseudomonas aeruginosa infections?

D. Spring, M. Welch, A. Floto, 2015, Future microbiology.

The discovery of antibacterial agents using diversity-oriented synthesis.

Andreas Bender, David R Spring, Martin Welch, 2009, Chemical communications.

A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds

D. Spring, Y. S. Tan, W. R. Galloway, 2015, Organic & biomolecular chemistry.

Strategies for the Diversity-Oriented Synthesis of Macrocycles.

D. Spring, T. A. King, Kim T Mortensen, 2019, Chemical reviews.

A Multidimensional Diversity‐Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles

Warren R. J. D. Galloway, David R. Spring, Hannah F. Sore, 2016, Angewandte Chemie.

4. Diversity-Oriented Synthesis

Warren R. J. D. Galloway, David R. Spring, Kieron M. G. O'Connell, 2011 .

Chemical library screening approaches to aid the design of protein- protein inhibitors

D. Spring, Luca Laraia, 2013 .

Gemmacin B: bringing diversity back into focus.

David R Spring, Martin Welch, D. Spring, 2008, Organic & biomolecular chemistry.

An expedient strategy for the diversity-oriented synthesis of macrocyclic compounds with natural product-like characteristics

Warren R. J. D. Galloway, David R. Spring, Cornelius J. O'Connor, 2016 .

Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform.

Stuart L Schreiber, David R Spring, Helen E Blackwell, 2002, Journal of the American Chemical Society.

Fluorous tagged small molecule microarrays.

D. Spring, M. Ladlow, R. L. Nicholson, 2007, Chemical communications.

A unified in vitro to in vivo fluorescence lifetime screening platform yields amyloid β aggregation inhibitors

Claire H. Michel, D. Spring, F. Hollfelder, 2022, bioRxiv.

The Pseudomonas Quinolone Signal (PQS)

D. Spring, M. Welch, J. Hodgkinson, 2016 .

A new Pseudomonas quinolone signal (PQS) binding partner: MexG† †Electronic supplementary information (ESI) available: Full experimental protocols and characterisation data. See DOI: 10.1039/c5sc04197j

D. Spring, M. Welch, J. Hodgkinson, 2016, Chemical science.

2-Heptyl-4-Quinolone, a Precursor of the Pseudomonas Quinolone Signal Molecule, Modulates Swarming Motility in Pseudomonas aeruginosa

D. Spring, M. Welch, G. O’Toole, 2011, Journal of bacteriology.

Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues.

D. Spring, M. Welch, S. Ley, 2011, Organic & biomolecular chemistry.

Identification of new quorum sensing autoinducer binding partners in Pseudomonas aeruginosa using photoaffinity probes† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc01270e Click here for additional data file.

D. Spring, M. Welch, B. Florea, 2017, Chemical science.

Microwave-assisted preparation of the quorum-sensing molecule 2-heptyl-3-hydroxy-4(1H)-quinolone and structurally related analogs

D. Spring, M. Welch, W. R. Galloway, 2012, Nature Protocols.

Structure-Activity Analysis of the Pseudomonas Quinolone Signal Molecule

D. Spring, M. Welch, W. R. Galloway, 2010, Journal of bacteriology.

Loving the poison: the methylcitrate cycle and bacterial pathogenesis.

D. Spring, M. Welch, Rafael Silva-Rocha, 2018, Microbiology.

Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics.

Kieron M. G. O'Connell, Brett M. Ibbeson, D. Spring, 2012, Organic & biomolecular chemistry.

Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa.

D. Spring, M. Welch, W. R. Galloway, 2012, Organic & biomolecular chemistry.

Discovery of a quorum sensing modulator pharmacophore by 3D small-molecule microarray screening.

D. Spring, M. Welch, G. Salmond, 2010, Organic & biomolecular chemistry.

Communications blackout? Do N-acylhomoserine-lactone-degrading enzymes have any role in quorum sensing?

D. Spring, M. Welch, F. G. Glansdorp, 2004, Microbiology.

The role of chemical synthesis in developing RiPP antibiotics.

D. Spring, D. R. Spring, S. Rowe, 2021, Chemical Society reviews.

Non-internalising antibody-drug conjugates.

D. Spring, Jonathan D Bargh, D. R. Spring, 2022, Chemical Society reviews.

The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance

D. Sherman, D. Spring, M. Troll, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Coumarin-derived transformable fluorescent sensor for Zn2+.

D. Spring, Zhaochao Xu, Jie Pan, 2012, Chemical communications.

Robust routes for the synthesis of N-acylated-L-homoserine lactone (AHL) quorum sensing molecules with high levels of enantiomeric purity

D. Spring, M. Welch, G. Salmond, 2011 .

2-Methoxycyclopentyl analogues of a Pseudomonas aeruginosa quorum sensing modulator.

D. Spring, M. Welch, G. Salmond, 2008, Molecular bioSystems.

Design and chance in the self-assembly of macromolecules.

D. Spring, X. Pei, J. Worrall, 2007, Biochemical Society transactions.

Divergent synthesis of biflavonoids yields novel inhibitors of the aggregation of amyloid β (1-42).

D. Spring, F. Hollfelder, W. R. Galloway, 2017, Organic & biomolecular chemistry.

Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking.

D. Spring, A. Ulrich, S. Afonin, 2018, Organic & biomolecular chemistry.

Variations on a Theme: Diverse N-Acyl Homoserine Lactone-Mediated Quorum Sensing Mechanisms in Gram-Negative Bacteria

D. Spring, M. Welch, J. Swatton, 2006, Science progress.

The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with LHSpTA peptide.

D. Spring, M. Rossmann, M. Hyvönen, 2018 .

Complete functionalisation of small and large diameter bromopolystyrene beads; applications for solid-supported reagents, scavengers and diversity-oriented synthesis.

David R Spring, D. Spring, M. Ladlow, 2004, Organic & biomolecular chemistry.

Discovery of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells

Brett M. Ibbeson, D. Spring, M. Welch, 2016, Beilstein journal of organic chemistry.

A lysosome-targetable fluorescent probe for imaging hydrogen sulfide in living cells.

D. Spring, Zhaochao Xu, Jingnan Cui, 2013, Organic letters.

Novel and efficient copper-catalysed synthesis of nitrogen-linked medium-ring biaryls.

D. Spring, M. Welch, W. R. Galloway, 2011, Chemistry.

Efficient Synthesis of Fmoc-ProtectedAzido Amino Acids

D. Spring, Y. H. Lau, 2011 .

Stereocontrolled Semisyntheses of Elliptone and 12aβ-Hydroxyelliptone.

D. Spring, D. Russell, H. Sore, 2017, Journal of natural products.

Importance of relative humidity in the oxidative ageing of organic aerosols: case study of the ozonolysis of maleic acid aerosol

F. Pope, D. Spring, P. Gallimore, 2011 .

Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design

Jason C Cole, David R Spring, Richard A. Sykes, 2020, J. Chem. Inf. Model..

Oxidation of Organocopper Compounds

D. Spring, S. J. Aves, D. R. Spring, 2011 .

Rational methods for the selection of diverse screening compounds.

David R Spring, David J Huggins, Ashok R Venkitaraman, 2011, ACS chemical biology.

2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in Pseudomonas aeruginosa

D. Spring, M. Welch, P. Tammela, 2020, International journal of molecular sciences.

Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials

David R. Spring, Martin Welch, Kieron M. G. O'Connell, 2013 .

Fluorescent sensing and discrimination of ATP and ADP based on a unique sandwich assembly of pyrene-adenine-pyrene.

D. Spring, Juyoung Yoon, Zhaochao Xu, 2011, Chemistry, an Asian journal.

Diversity‐Oriented Synthesis: Developing New Chemical Tools to Probe and Modulate Biological Systems

D. Spring, Luca Laraia, W. R. Galloway, 2014 .

Regioselectivity in ThermalRhodium(II)-Catalysed Büchner-Type Reactions of SubstitutedAryl Halides: Studies towards the Synthesis of Halide-SubstitutedCycloheptatrienes

D. Spring, W. R. Galloway, E. Wyatt, 2011 .

A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066

David R. Spring, Marko Hyvönen, D. Spring, 2017, Bioorganic & medicinal chemistry.

Sulfatase-cleavable linkers for antibody-drug conjugates†

Stephen J. Walsh, J. Carroll, D. Spring, 2020, Chemical science.

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst† †Dedicated to Professor Stuart L. Schreiber on the occasion of his 60th birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05313k Click here for additional

Stephen J. Walsh, David R Spring, Martin Welch, 2017, Chemical science.

The oxidation of organocuprates--an offbeat strategy for synthesis.

D. Spring, D. Surry, D. R. Spring, 2006, Chemical Society reviews.

Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion†

Anthony R. Bradley, Christopher G. Dowson, Katherine E. McAuley, 2020, Chemical science.

Partially Saturated Bicyclic Heteroaromatics as an sp3‐Enriched Fragment Collection

Warren R. J. D. Galloway, David R. Spring, D. Spring, 2016, Angewandte Chemie.

Ratiometric fluorescent and colorimetric sensors for Cu2+ based on 4,5-disubstituted-1,8-naphthalimide and sensing cyanide via Cu2+ displacement approach

David R. Spring, Jie Pan, Juyoung Yoon, 2010 .

A dual-enzyme cleavable linker for antibody-drug conjugates.

Stephen J. Walsh, J. Carroll, D. Spring, 2021, Chemical communications.

An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds.

D. Spring, A. Bond, T. Moss, 2020, Chemical communications.

The Serratia LuxR family regulator CarR39006 activates transcription independently of cognate quorum sensing signals

D. Spring, G. Salmond, Timothy M. Carlton, 2011, Molecular microbiology.

Small molecules in biology.

D. Spring, A. Hamilton, A. Tavassoli, 2011, Chemical Society reviews.

All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading

Stephen J. Walsh, J. Carroll, D. Spring, 2022, Chemical science.

Efficient and selective antibody modification with functionalised divinyltriazines.

Stephen J. Walsh, D. Spring, N. Robertson, 2020, Organic & biomolecular chemistry.

General dual functionalisation of biomacromolecules via a cysteine bridging strategy.

Stephen J. Walsh, J. Carroll, D. Spring, 2020, Organic & biomolecular chemistry.

Second-generation CK2 alpha inhibitors targeting the alpha D pocket.

D. Spring, M. Rossmann, M. Hyvönen, 2018 .

Novel non-ATP competitive small molecules targeting the CK2 alpha / beta interface.

D. Spring, M. Hyvönen, A. North, 2018 .

Which microbial factors really are important in Pseudomonas 1 aeruginosa infections ? 2 3

Martin, D. Spring, A. Floto, 2015 .

Design and Synthesis of a Biotinylated Chemical Probe for Detecting the Molecular Targets of an Inhibitor of the Production of the Pseudomonas aeruginosa Virulence Factor Pyocyanin

D. Spring, W. R. Galloway, J. Hodgkinson, 2013, Molecules.

Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections

David R. Spring, Sarah L. Kidd, Natalia Mateu, 2018, Front. Chem..

Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry.

D. Spring, L. Itzhaki, M. Hyvönen, 2019, Organic & biomolecular chemistry.

Synthesis and biological evaluation of 1,2-disubsubstituted 4-quinolone analogues of Pseudonocardia sp. natural products

D. Spring, M. Welch, J. Hodgkinson, 2018, Beilstein journal of organic chemistry.

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

D. Spring, L. Itzhaki, Y. S. Tan, 2016, Scientific Reports.

A novel complexity-to-diversity strategy for the diversity-oriented synthesis of structurally diverse and complex macrocycles from quinine.

D. Spring, J J Ciardiello, H L Stewart, 2017, Bioorganic & medicinal chemistry.

Stapled peptides as a new technology to investigate protein–protein interactions in human platelets

D. Spring, Y. S. Tan, C. Verma, 2018, Chemical science.

Cell-cell communication in Gram-negative bacteria.

D. Spring, M. Welch, J. Swatton, 2005, Molecular bioSystems.

Direct Synthesis of N-Functionalized Dipropargylamine Linkers as Models for Use in Peptide Stapling

D. Spring, H. Sore, Andrea Renzetti, 2019, Synlett.

The effect of humidity on the ozonolysis of unsaturated compounds in aerosol particles.

Stephen J. Fuller, F. Pope, D. Spring, 2012, Physical chemistry chemical physics : PCCP.

Structure-activity relationships of Erwinia carotovora quorum sensing signaling molecules.

D. Spring, M. Welch, G. Salmond, 2005, Bioorganic & medicinal chemistry letters.

Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling

David R. Spring, D. Spring, M. Rossmann, 2016, Chembiochem : a European journal of chemical biology.

D. Spring, Y. S. Tan, C. Verma, 2019, Chemical science.

Virulence in Pectobacterium atrosepticum is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)ppGpp

D. Spring, M. Welch, G. Salmond, 2013, Molecular microbiology.

Mastering the chemical language of bacteria.

D. Spring, M. Welch, J. Hodgkinson, 2009, Chemistry & biology.

Using chemical probes to investigate the sub-inhibitory effects of azithromycin.

D. Spring, M. Welch, J. Swatton, 2008, Organic & biomolecular chemistry.

Learning the language of bacteria.

D. Spring, M. Welch, J. Hodgkinson, 2007, ACS chemical biology.

Proceedings of the Chemical Society. January 1963

D. Spring, M. Welch, G. Salmond, 1963 .

Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5-6-mer) Peptides.

D. Spring, J. Nissink, Andrew P Thomas, 2021, Journal of medicinal chemistry.

Towards drugging the 'undruggable': enhancing the scaffold diversity of synthetic small molecule screening collections using diversity-oriented synthesis

D. Spring, W. Galloway, 2013 .

Two-directional synthesis as a tool for diversity-oriented synthesis: Synthesis of alkaloid scaffolds

David R Spring, Kieron M. G. O'Connell, Warren R J D Galloway, 2012, Beilstein journal of organic chemistry.

Is synthesis the main hurdle for the generation of diversity in compound libraries for screening?

David R Spring, Warren Rjd Galloway, D. Spring, 2009, Expert opinion on drug discovery.

Ligand binding kinetics of the quorum sensing regulator PqsR.

D. Spring, M. Welch, J. Hodgkinson, 2013, Biochemistry.

CHAPTER 8:Double-click Stapled Peptides for Inhibiting Protein–Protein Interactions

D. Spring, L. Itzhaki, Y. H. Lau, 2017 .

Synthesis and Reactivity of a Bis-Strained Alkyne Derived from 1,1′-Biphenyl-2,2′,6,6′-tetrol

D. Spring, N. Robertson, M. Wills, 2019, ACS omega.

Enriching chemical space with diversity-oriented synthesis.

David R Spring, Gemma L Thomas, Emma E Wyatt, 2006, Current opinion in drug discovery & development.

A novel complexity-to-diversity strategy for the diversity-oriented synthesis of structurally diverse and complex macrocycles from quinine.

D. Spring, H. Sore, J. Ciardiello, 2017, Bioorganic & medicinal chemistry.

Controlling the contents of microdroplets by exploiting the permeability of PDMS.

Santoshkumar N. Patil, D. Spring, M. Welch, 2011, Lab on a chip.

Ratiometric fluorescent and colorimetric sensors for Cu2+ based on 4,5-disubstituted-1,8-naphthalimide and sensing cyanide via Cu2+ displacement approach

D. Spring, Juyoung Yoon, Zhaochao Xu, 2010 .

Fluorescent sensing and discrimination of ATP and ADP based on a unique sandwich assembly of pyrene-adenine-pyrene.

D. Spring, Juyoung Yoon, Zhaochao Xu, 2011, Chemistry, an Asian journal.

Stephen J. Walsh, D. Spring, M. Welch, 2017, Chemical science.

Loving the poison: the methylcitrate cycle and bacterial pathogenesis.

D. Spring, M. Welch, Rafael Silva-Rocha, 2018, Microbiology.

Multifunctional supramolecular polymer networks as next-generation consolidants for archaeological wood conservation

D. Spring, M. Welch, C. Toprakcioglu, 2014, Proceedings of the National Academy of Sciences.

Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.

A. Plowright, D. Spring, M. Welch, 2008, Chemical communications.

Investigating peptide sequence variations for 'double-click' stapled p53 peptides.

D. Spring, D. Lane, G. McKenzie, 2014, Organic & biomolecular chemistry.

The reductive cleavage of picolinic amides

D. Spring, C. D. Fusco, D. H. O. Donovan, 2016 .

Drug discovery: A question of library design

P. Hajduk, D. Spring, W. Galloway, 2011, Nature.

Studies on the Biomimetic Synthesis of the Manzamine Alkaloids

D. Spring, T. Claridge, J. Baldwin, 1999 .

Stephen J. Walsh, J. Carroll, D. Spring, 2018, Chemical science.

Exploiting domino enyne metathesis mechanisms for skeletal diversity generation.

D. Spring, R. J. Spandl, H. Rudyk, 2008, Chemical communications.

Novel and efficient copper-catalysed synthesis of nitrogen-linked medium-ring biaryls.

D. Spring, M. Welch, Albert Isidro-Llobet, 2011, Chemistry.

Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling.

Stephen J. Walsh, D. Spring, Yuteng Wu, 2019, Chemical communications.

Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late-Stage Functionalisation.

D. Spring, S. Krajcovicova, 2023, Angewandte Chemie.

Engineering of new prodigiosin-based biosensors of Serratia for facile detection of short-chain N-acyl homoserine lactone quorum-sensing molecules.

D. Spring, G. Salmond, Timothy M. Carlton, 2010, Environmental microbiology reports.

Mastering the chemical language of bacteria.

D. Spring, M. Welch, J. Hodgkinson, 2009, Chemistry & biology.