J. Gnarra

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Mutations of the VHL tumour suppressor gene in renal carcinoma

J. Brooks, W. Linehan, L. Schmidt, 1994, Nature Genetics.

Identification of the von Hippel-Lindau disease tumor suppressor gene.

J. Gnarra, F. Latif, F. Duh, 1993, Science.

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

J. Herman, W. Linehan, J. Gnarra, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Special Notice to Contributors

S. Ennis, C. Auffray, W. Linehan, 1996 .

Loss of heterozygosity occurs centromeric to RB without associated abnormalities in the retinoblastoma gene in tumors from patients with metastatic renal cell carcinoma.

J. Gnarra, C. Florence, M. Walther, 1995, The Journal of urology.

Interleukin (IL)-2 and IL-3 induce distinct but overlapping responses in murine IL-3-dependent 32D cells transduced with human IL-2 receptor beta chain: involvement of tyrosine kinase(s) other than p56lck.

M. Erdos, J. Gnarra, W. Leonard, 1992, Proceedings of the National Academy of Sciences of the United States of America.

The beta-chain of the IL-2 receptor (p70) is tyrosine-phosphorylated on YT and HUT-102B2 cells.

J. Gnarra, W. Leonard, M. Sharon, 1989, Journal of Immunology.

Mapping the X chromosome breakpoint in two papillary renal cell carcinoma cell lines with a t(X;1)(p11.2;q21.2) and the first report of a female case.

C. Cooper, J. Gnarra, S. Fisher, 1995, Cytogenetics and cell genetics.

Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines.

J. Minna, A. Gazdar, W. Linehan, 1994, Oncogene.

Early Events in Target‐Cell Lysis by Cytotoxic T Cells a

V. Engelhard, J. Gnarra, L. Gray, 1988, Annals of the New York Academy of Sciences.

The role of K+ in the regulation of the increase in intracellular Ca2+ mediated by the T lymphocyte antigen receptor

V. Engelhard, J. Gnarra, J. Russell, 1987, Cell.

A 100-kilodalton protein is associated with the murine interleukin 2 receptor: biochemical evidence that p100 is distinct from the alpha and beta chains.

J. Gnarra, W. Leonard, M. Sharon, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Integrin a v b 3 and Fibronectin Upregulate Slug in Cancer Cells to Promote Clot Invasion and Metastasis

J. Gnarra, J. Maranchie, J. Pilch, 2013 .

Microenvironment and Immunology Integrin a v b 3 and Fibronectin Upregulate Slug in Cancer Cells to Promote Clot Invasion and Metastasis

J. Gnarra, J. Maranchie, J. Pilch, 2013 .

Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor

Julie A. Brown, J. Gnarra, H. Xin, 2010, Oncogene.

Clinical and genetic characterization of pheochromocytoma in von Hippel-Lindau families: comparison with sporadic pheochromocytoma gives insight into natural history of pheochromocytoma.

P. Choyke, W. Linehan, J. Gnarra, 1999, The Journal of urology.

(list includes refereed review articles in leading journals, as noted)

Simon E. Fisher, Jeremy Clark, Helen J. Blair, 2012 .

Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients.

W. Linehan, J. Gnarra, I. Lubensky, 1996, The American journal of pathology.

EAF2 loss enhances angiogenic effects of Von Hippel-Lindau heterozygosity on the murine liver and prostate

J. Gnarra, Laura E. Pascal, L. Rigatti, 2011, Angiogenesis.

von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease.

M. Emmert-Buck, A. Vortmeyer, W. Linehan, 1997, Human pathology.

Detection of von Hippel-Lindau disease gene mutations in paraffin-embedded sporadic renal cell carcinoma specimens.

W. Linehan, J. Gnarra, B. Zbar, 1996, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

Association of the von Hippel–Lindau Protein with AUF1 and Posttranscriptional Regulation of VEGFA mRNA

Julie A. Brown, J. Gnarra, H. Fan, 2011, Molecular Cancer Research.

Association of the von Hippel-Lindau protein with AUF 1 and post-transcriptional regulation of Vascular Endothelial Growth Factor A mRNA

Julie A. Brown, J. Gnarra, H. Fan, 2011 .

The use of molecular genetic analysis in the diagnosis of renal cell carcinoma

W. Linehan, J. Gnarra, S. Liu, 2004, World Journal of Urology.

Expression of Pax-2 in human renal cell carcinoma and growth inhibition by antisense oligonucleotides.

J. Gnarra, G. Dressler, 1995, Cancer research.

Loss of heterozygosity of the human cytosolic glutathione peroxidase I gene in lung cancer.

J. Gnarra, K. Cowan, J. Moscow, 1994, Carcinogenesis.

Human interleukin 2 receptor beta-chain gene: chromosomal localization and identification of 5' regulatory sequences.

J. Gnarra, W. Leonard, O. Mcbride, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Induction of cell cycle arrest and apoptosis in human prostate carcinoma cells by a recombinant adenovirus expressing p27Kip1

J. Gnarra, W. Rayford, A. Katner, 2002, The Prostate.

Possible association between IL-2 receptors and class I HLA molecules on T cells.

J. Gnarra, W. Leonard, M. Sharon, 1988, Journal of immunology.

Loss of HLA haplotype and B locus down-regulation in melanoma cell lines.

F. Marincola, J. Gnarra, J. Taubenberger, 1994, Journal of immunology.

Examination of human tumors for rhoA mutations.

W. Linehan, J. Gnarra, Y. Weng, 1994, Oncogene.

Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density.

R. Klausner, W. Linehan, J. Gnarra, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Spatial and temporal characteristics of the increase in intracellular Ca2+ induced in cytotoxic T lymphocytes by cellular antigen.

V. Engelhard, J. Gnarra, L. Gray, 1988, Journal of immunology.

Increased intracellular cyclic adenosine monophosphate inhibits T lymphocyte-mediated cytolysis by two distinct mechanisms

V. Engelhard, J. Gnarra, E. Hewlett, 1988, The Journal of experimental medicine.

Demonstration of a calcium influx in cytolytic T lymphocytes in response to target cell binding.

V. Engelhard, J. Gnarra, L. Gray, 1987, Journal of immunology.

Progelatinase A mRNA expression in cell lines derived from tumors in patients with metastatic renal cell carcinoma correlates inversely with survival.

W. Linehan, J. Gnarra, I. Lubensky, 1997, Urology.

Effect of suramin on the mitogenic response of the human prostate carcinoma cell line PC‐3

W. M. Linehan, J. Gnarra, M. Walther, 1993, Cancer.

CLINICAL AND GENETIC CHARACTERIZATION OF COMPARISON WITH SPORADIC PHEOCHROMOCYTOMA GIVES INSIGHT INTO NATURAL HISTORY OF PHEOCHROMOCYTOMA PHEOCHROMOCYTOMA IN VON HIPPEL-LINDAU FAMILIES:

P. Choyke, W. Linehan, J. Gnarra, 1999 .

Renal cell carcinoma. Molecular genetics and clinical implications.

W. Linehan, J. Gnarra, M. Walther, 1995, Surgical oncology clinics of North America.

Molecular genetic studies of sporadic and familial renal cell carcinoma.

W. Linehan, J. Gnarra, M. Lerman, 1993, The Urologic clinics of North America.

Genotype–phenotype correlations of pheochromocytoma in two large von Hippel–Lindau (VHL) type 2A kindreds with different missense mutations

J. Gnarra, W. Rubinstein, E. Feingold, 2011, American journal of medical genetics. Part A.

von Hippel-Lindau syndrome: cloning and identification of the plasma membrane Ca(++)-transporting ATPase isoform 2 gene that resides in the von Hippel-Lindau gene region.

D. Paslier, L. Schmidt, J. Gnarra, 1993, Cancer research.

Structure, function, and regulation of the interleukin-2 receptor and identification of a novel immune activation gene.

J. Gnarra, W. Leonard, M. Sharon, 1990, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Chromosome imbalances in papillary renal cell carcinoma and first cytogenetic data of familial cases analyzed by comparative genomic hybridization.

W. Linehan, P. Lichter, J. Gnarra, 1996, Cytogenetics and cell genetics.

Comparative genomic analysis of tumors: detection of DNA losses and amplification.

Carissa A. Sanchez, M. Wigler, W. M. Linehan, 1995, Proceedings of the National Academy of Sciences of the United States of America.

A microdissection technique for archival DNA analysis of specific cell populations in lesions < 1 mm in size.

L. Liotta, M. Emmert-Buck, W. Linehan, 1995, The American journal of pathology.

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice.

J M Ward, R D Klausner, M. Emmert-Buck, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene.

R. Klausner, W. Linehan, J. Gnarra, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Chromosome 17p deletions and p53 mutations in renal cell carcinoma.

W. Linehan, J. Gnarra, S. Liu, 1993, Cancer research.

Regional DNA hypermethylation at D17S5 precedes 17p structural changes in the progression of renal tumors.

S. Baylin, W. Isaacs, J. Gnarra, 1993, Cancer research.

Identification of an Actin Binding Region and a Protein Kinase C Phosphorylation Site on Human Fascin*

J. Gnarra, T. Obinata, P. Matsudaira, 1997, The Journal of Biological Chemistry.

Germline mutations in the von Hippel–Lindau disease tumor suppressor gene: Correlations with phenotype

W. Linehan, L. Schmidt, J. Gnarra, 1995, Human mutation.

Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma.

R. Klausner, W. Linehan, L. Schmidt, 1996, Biochimica et biophysica acta.

Susceptibility to vascular neoplasms but no increased susceptibility to renal carcinogenesis in Vhl knockout mice.

J. Gnarra, L. Pluta, C. Walker, 2003, Carcinogenesis.

Metastatic models and molecular genetics of prostate cancer.

W. M. Linehan, J. Gnarra, P. Steeg, 1992, Journal of the National Cancer Institute.

Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis.

R. Klausner, J. Gnarra, A. Pause, 2001, Proceedings of the National Academy of Sciences of the United States of America.

The von Hippel-Lindau Tumor Suppressor Gene Inhibits Hepatocyte Growth Factor/Scatter Factor-Induced Invasion and Branching Morphogenesis in Renal Carcinoma Cells

R. Klausner, W. Linehan, J. Gnarra, 1999, Molecular and Cellular Biology.

Loss of heterozygosity on the short arm of chromosome 3 in mesothelioma cell lines and solid tumors

W. M. Linehan, J. Gnarra, B. Zbar, 1994, Genes, chromosomes & cancer.

Genetic basis of renal cell cancer.

W. Linehan, J. Gnarra, M. Lerman, 1993, Important advances in oncology.

Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations.

R. Klausner, W. Linehan, J. Gnarra, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth.

J. Gnarra, W. Rathmell, M. Simon, 2003, Cancer cell.

One-megabase yeast artificial chromosome and 400-kilobase cosmid-phage contigs containing the von Hippel-Lindau tumor suppressor and Ca(2+)-transporting adenosine triphosphatase isoform 2 genes.

D. Paslier, J. Gnarra, H. Li, 1994, Cancer research.

von Hippel-Lindau disease gene deletion detected in microdissected sporadic human colon carcinoma specimens.

L. Liotta, M. Emmert-Buck, W. Linehan, 1996, Human pathology.

Renal cell carcinoma. Cytogenetic analysis of tumors and cell lines.

W. Linehan, J. Gnarra, S. Liu, 1995, Cancer genetics and cytogenetics.

Loss of heterozygosity on the short arm of chromosome 3 in sporadic, von hippel‐lindau disease‐associated, and familial pheochromocytoma

J. Gnarra, B. Zbar, M. Zeiger, 1995, Genes, chromosomes & cancer.

Molecular Studies of the VHL Tumor Suppressor Gene in Renal Cell Carcinoma

W. Linehan, J. Gnarra, M. Lerman, 1995 .

Expression of nm23 in cell lines derived from patients with metastatic renal cell carcinoma.

W. Linehan, J. Gnarra, R. Pozzatti, 1995, The Journal of urology.

The gene encoding the Act-2 cytokine. Genomic structure, HTLV-I/Tax responsiveness of 5' upstream sequences, and chromosomal localization.

J. Gnarra, W. Leonard, H. Seuánez, 1991, The Journal of biological chemistry.

von Hippel-Lindau gene mutations in human and rodent renal tumors--association with clear cell phenotype.

J. Gnarra, 1998, Journal of the National Cancer Institute.

Von Hippel-Lindau Syndrome : Cloning and Identification of the Plasma Membrane Ca + +-transporting ATPase Isoform 2 Gene That Resides in the Von Hippel-Lindau Gene Region 1

William, Yao, Thomas, 2006 .

Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency.

Y. Pekarsky, C. Croce, G. Calin, 2005, Cancer research.

Integrin αvβ3 and fibronectin upregulate Slug in cancer cells to promote clot invasion and metastasis.

J. Gnarra, J. Maranchie, J. Pilch, 2013, Cancer research.

Genetics of renal-cell carcinoma and evidence for a critical role for von Hippel-Lindau in renal tumorigenesis.

W. Linehan, J. Gnarra, M. Lerman, 1995, Seminars in oncology.

A recombinant adenovirus expressing p7(Kip1) induces cell cycle arrest and apoptosis in human 786-0 renal carcinoma cells.

J. Gnarra, W. Rayford, A. Katner, 2002, The Journal of urology.

The Multisubunit Interleukin‐2 Receptor

J. Gnarra, W. Leonard, M. Sharon, 1990, Annals of the New York Academy of Sciences.

Net Exchange of CO2 in a Mid-Latitude Forest

D. Paslier, S. Wofsy, P. Bakwin, 1993, Science.