J. Parsons

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Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation

Alissa M. Weaver, A. Karginov, Andrew W. Kinley, 2001, Current Biology.

Cortactin: coupling membrane dynamics to cortical actin assembly

S. Weed, J. Parsons, J Thomas Parsons, 2001, Oncogene.

Cell Migration: Integrating Signals from Front to Back

G. Borisy, J. Parsons, R. Firtel, 2003, Science.

A Role for Focal Adhesion Kinase in Phenylephrine-induced Hypertrophy of Rat Ventricular Cardiomyocytes*

J. Taylor, J. Parsons, J. Rovin, 2000, The Journal of Biological Chemistry.

Src family kinases, key regulators of signal transduction

J. Parsons, S. Parsons, J Thomas Parsons, 2004, Oncogene.

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

Martin A. Schwartz, Alan Rick Horwitz, J. Parsons, 2010, Nature Reviews Molecular Cell Biology.

Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene

J. Parsons, S. Kanner, A. Reynolds, 1989, Molecular and cellular biology.

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

Daniel Gioeli, J. Parsons, D. Tschumperlin, 2010, PloS one.

Interaction of Focal Adhesion Kinase with Cytoskeletal Protein Talin (*)

J. Parsons, J. Guan, J. Hildebrand, 1995, The Journal of Biological Chemistry.

FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

Donna J. Webb, Sheila M. Thomas, J. Parsons, 2004, Nature Cell Biology.

Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again

Donna J. Webb, J. Parsons, D. Webb, 2002, Nature Cell Biology.

Structure of the BH Domain from Graf and Its Implications for Rho GTPase Recognition*

K. Longenecker, J. Parsons, Z. Dauter, 2000, The Journal of Biological Chemistry.

Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK

J. Parsons, M. Schaller, B. S. Cobb, 1994, Molecular and cellular biology.

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains

J. Parsons, J. Hildebrand, M. Schaller, 1995, The Journal of cell biology.

Genetics of src: structure and functional organization of a protein tyrosine kinase.

J. Parsons, M. Weber, J. Parsons, 1989, Current topics in microbiology and immunology.

Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells

J. Parsons, E. Bissonette, R. Adams, 2001, Oncogene.

Characterization of c-myc proteins from avian bursal lymphoma cell lines.

J. Parsons, J. Morgan, 1986, Virology.

Identification of two focal adhesion targeting sequences in the adapter molecule p130(Cas).

J. Parsons, M. Harte, A. Bouton, 2000, Biochimica et biophysica acta.

Identification and characterization of novel substrates for protein tyrosine kinases.

J. Parsons, D. Flynn, M. Schaller, 1993, Progress in nucleic acid research and molecular biology.

Identification of an amino terminal domain required for the transforming activity of the Rous sarcoma virus src protein.

J. Parsons, V. Raymond, 1987, Virology.

Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stability

J. Parsons, H. Wang, 1989, Journal of virology.

Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein

J. Parsons, S. Kanner, J. Gibbs, 1991, Molecular and cellular biology.

Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets

J. Parsons, J. Brugge, B. Haimovich, 1992, The Journal of cell biology.

FRNK Expression Promotes Smooth Muscle Cell Maturation During Vascular Development and After Vascular Injury

J. Parsons, M. Rojas, Haruko Hayasaka, 2008, Arteriosclerosis, thrombosis, and vascular biology.

CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein

J. Parsons, S. Fu, F. Gaskin, 1994, The Journal of experimental medicine.

p130Cas, a Substrate Associated with v-Src and v-Crk, Localizes to Focal Adhesions and Binds to Focal Adhesion Kinase*

J. Parsons, J. Hildebrand, M. Harte, 1996, The Journal of Biological Chemistry.

The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly.

A. Karginov, J. Parsons, K. Martin, 2002, Molecular biology of the cell.

Mislocalization or Reduced Expression of Arf GTPase-activating Protein ASAP1 Inhibits Cell Spreading and Migration by Influencing Arf1 GTPase Cycling*

J. Parsons, P. Grigera, Yunhao Liu, 2005, Journal of Biological Chemistry.

Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK

J. Parsons, M. Schaller, C. A. Borgman, 1993, Molecular and cellular biology.

Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells

J. Parsons, S. Kanner, A. B. Reynolds, 1991 .

CD47 Blockade as an Adjuvant Immunotherapy for Resectable Pancreatic Cancer

J. Parsons, C. Slingluff, K. Ravichandran, 2017, Clinical Cancer Research.

Oncogene-mediated Multistep Transformation of C 3 H 10 T 1 / 2 Cells 1

J. Parsons, E. Taparowsky, M. Heaney, 2006 .

Oncogene-mediated multistep transformation of C3H10T1/2 cells.

J. Parsons, E. Taparowsky, M. Heaney, 1987, Cancer research.

FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts

J. Parsons, M. Iwanicki, T. Vomastek, 2008, Journal of Cell Science.

Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins

J. Parsons, S. Kanner, A. Reynolds, 1989, Molecular and cellular biology.

Activation of pp60c-src transforming potential by mutations altering the structure of an amino terminal domain containing residues 90-95.

J. Parsons, T. J. Lansing, A. Reynolds, 1988, Oncogene research.

Site-directed mutagenesis of the src gene of Rous sarcoma virus: construction and characterization of a deletion mutant temperature sensitive for transformation

J. Parsons, D. Bryant, 1982, Journal of virology.

The reorientation of cell nucleus promotes the establishment of front-rear polarity in migrating fibroblasts.

J. Parsons, M. Iwanicki, T. Vomastek, 2013, Journal of molecular biology.

Direct Proof of the 5′ to 3′ Transcriptional Jump During Reverse Transcription of the Avian Retrovirus Genome by DNA Sequencing

J. Parsons, A. Faras, C. Omer, 1981, Journal of virology.

Molecular cloning of avian sarcoma virus closed circular DNA: structural and biological characterization of three recombinant clones

J. Parsons, P. Highfield, T. Gilmer, 1980, Journal of virology.

pp6Ov-src Inactivate Transformation and Modulate Membrane Stability

J. Parsons, H. Wang, 2003 .

Immunoaffinity purification of tyrosine-phosphorylated cellular proteins.

J. Parsons, S. Kanner, A. Reynolds, 1989, Journal of immunological methods.

Identification of phosphorylation sites in betaPIX and PAK1.

J. Shabanowitz, D. Hunt, J. Parsons, 2007, Journal of Cell Science.

Rous sarcoma virus variants that encode src proteins with an altered carboxy terminus are defective for cellular transformation

J. Parsons, D. Bryant, V. Wilkerson, 1985, Journal of virology.

The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110.

J. Parsons, S. Kanner, R. Vines, 1991, The EMBO journal.

RNase H hydrolysis of the 5′ terminus of the avian sarcoma virus genome during reverse transcription

J. Parsons, M. Collett, A. Faras, 1978, Nature.

CHAPTER 78 – Integrin Signaling: Cell Migration, Proliferation, and Survival

J. Parsons, K. Martin, R. Tilghman, 2003 .

Shifting Paradigms in Tumor Metastasis: Challenges and Opportunities—A Workshop Report

J. Parsons, B. Zetter, S. Mohla, 2002, Cancer biology & therapy.

Closing the GAP in a signal transduction pathway.

J. Parsons, 1990, Trends in genetics : TIG.

Focal adhesion kinase: an integrin-linked protein tyrosine kinase.

J. Parsons, M. Schaller, M. D. Schaller, 1993, Trends in cell biology.

Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts

L. Addadi, J. Parsons, B. Geiger, 2006, Journal of Cell Science.

Stable Association of PYK2 and p130Cas in Osteoclasts and Their Co-localization in the Sealing Zone*

J. Parsons, G. Rodan, I. Nakamura, 1999, The Journal of Biological Chemistry.

Novel tyrosine phosphorylations accompany the activation of pp60c-src during chemical carcinogenesis.

J. Parsons, S. Kanner, T. Gilmer, 1989, Oncogene.

MC29 deletion mutants which fail to transform chicken macrophages are competent for transformation of quail macrophages

J. Parsons, B. Biegalke, M. Heaney, 1987, Journal of virology.

Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions

J. Parsons, J. Hildebrand, M. Schaller, 1993, The Journal of cell biology.

Tyrosine phosphorylation of the focal adhesion kinase pp125FAK during development: relation to paxillin.

J. Parsons, C. Turner, M. Schaller, 1993, Journal of cell science.

Immunological methods for the detection of phosphotyrosine-containing proteins in neural tissues

J. Parsons, S. Parsons, C. Ely, 1992 .

Identification and Characterization of a Novel Cytoskeleton-Associated pp6Osrc Substrate

J. Parsons, S. Kanner, A. Reynolds, 2022 .

Inhibition of the tyrosine kinase activity of v-src, v-fgr, and v-yes gene products by a monoclonal antibody which binds both amino and carboxy peptide fragments of pp60v-src

J. Parsons, D. Benjamin, S. Parsons, 1987, Journal of virology.

Selective Expression of an Endogenous Inhibitor of FAK Regulates Proliferation and Migration of Vascular Smooth Muscle Cells

J. Parsons, G. Owens, C. Regan, 2001, Molecular and Cellular Biology.

J. Parsons, S. Kanner, A. Reynolds, 1991, Molecular and cellular biology.

Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase.

J. Parsons, E. Villa-Moruzzi, M. Bianchi, 2001, The Biochemical journal.

Disruption of FRNK expression by gene targeting of the intronic promoter within the focal adhesion kinase gene

J. Parsons, K. Martin, Haruko Hayasaka, 2007, Journal of cellular biochemistry.

FRNK, the autonomously expressed C‐terminal region of focal adhesion kinase, is uniquely regulated in vascular smooth muscle: Analysis of expression in transgenic mice

J. Parsons, Haruko Hayasaka, Koh‐hei Masumoto, 2005, Journal of cellular biochemistry.

Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model

H. Frierson, J. Parsons, D. Theodorescu, 2009, Molecular Cancer Therapeutics.

Results Disruption of FAK Expression in the Prostate of Normal and TRAMP Mice To assess the role of FAK in prostate cancer progression in TRAMP mice , normal and TRAMP mice were interbred

H. Frierson, J. Parsons, D. Theodorescu, 2009 .

Identification of integrin-stimulated sites of serine phosphorylation in FRNK, the separately expressed C-terminal domain of focal adhesion kinase: a potential role for protein kinase A.

J. Parsons, R. Adams, M. Schaller, 1997, The Biochemical journal.

pp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src

J. Parsons, S. Parsons, D. Luttrell, 1989, Molecular and cellular biology.

In vitro transcription of reconstituted 35s RNA.tRNAtrp template.primer complexes by the avian oncornavirus DNA polymerase. Effect of temperature on the size of the DNA transcripts.

J. Parsons, M. Collett, J. Leis, 1978, Virology.

In vitro synthesis of a unique RNA species by a T particle of vesicular stomatitis virus

S. Emerson, J. Parsons, P. Dierks, 1977, Journal of virology.

Regulated Expression of Focal Adhesion Kinase-Related Nonkinase, the Autonomously Expressed C-Terminal Domain of Focal Adhesion Kinase

J. Parsons, J. Lacoste, K. Nolan, 1999, Molecular and Cellular Biology.

Tyrosine phosphorylation of three cellular proteins correlates with transformation of rat 1 cells by pp60src

J. Parsons, S. Kanner, A. Bouton, 1991, Molecular carcinogenesis.

Site-directed mutagenesis of the gag-myc gene of avian myelocytomatosis virus 29: biological activity and intracellular localization of structurally altered proteins

J. Parsons, M. Heaney, J. Pierce, 1986, Journal of virology.

Amino acid alterations within a highly conserved region of the Rous sarcoma virus src gene product pp60src inactivate tyrosine protein kinase activity

J. Parsons, D. Bryant, 1984, Molecular and cellular biology.

Identification of transcriptional elements within the long terminal repeat of Rous sarcoma virus

J. Parsons, G. Gilmartin, 1983, Molecular and cellular biology.

Identification ofTranscriptional Elements Within theLong Terminal Repeat ofRousSarcoma Virus

J. Parsons, Gregory M. GILMARTINtAND, 1983 .

Integrin-mediated signaling in normal and malignant cells: a role of protein tyrosine kinases.

J. Parsons, R. K. Malik, 1996, Biochimica et biophysica acta.

Assay and purification and focal adhesion kinase.

J. Parsons, J. Lacoste, A. Ma, 1998, Methods in enzymology.

Cortactin Interacts with WIP in Regulating Arp2/3 Activation and Membrane Protrusion

Alissa M. Weaver, A. Karginov, Andrew W. Kinley, 2003, Current Biology.

Protein-synthetic capacities of liver nuclear subfractions.

J. Parsons, J. Laszlo, W. Carter, 1966, The Journal of biological chemistry.

Focal Adhesion Kinase (FAK) Regulates Insulin-stimulated Glycogen Synthesis in Hepatocytes*

J. Parsons, A. Cheung, Danshan Huang, 2002, The Journal of Biological Chemistry.

Regulation of focal adhesion targeting and inhibitory functions of the FAK related protein FRNK using a novel estrogen receptor "switch".

J. Parsons, K. Martin, S. Boerner, 2002, Cell motility and the cytoskeleton.

Identification and characterization of a cytoskeleton-associated, epidermal growth factor sensitive pp60c-src substrate.

J. Parsons, M. Maa, S. Parsons, 1992, Oncogene.

The identification of p130cas-binding proteins and their role in cellular transformation.

J. Parsons, M. Harte, A. Bouton, 1996, Oncogene.

Protein-tyrosine kinases, oncogenes, and cancer.

J. Parsons, S. Parsons, 1993, Important advances in oncology.

Purification of virus-specific RNA from chicken cells infected with avian sarcoma virus: identification of genome-length and subgenome-leghth viral RNAs

J. Parsons, P. Dierks, P. Lewis, 1978, Journal of virology.

A new approach to the isolation of RNA-DNA hybrids and its application to the quantitative determination of labeled tumor virus RNA.

J. Parsons, J. Coffin, C. Weissmann, 1974, Journal of molecular biology.

Serine phosphorylation of focal adhesion kinase in interphase and mitosis: a possible role in modulating binding to p130(Cas).

J. Parsons, E. Schaefer, A. Ma, 2001, Molecular biology of the cell.

Focal Adhesion Kinase: a regulator of focal adhesion dynamics and cell movement

S. Weed, J. Parsons, K. Martin, 2000, Oncogene.

Identification of phosphorylation sites in βPIX and PAK1

J. Shabanowitz, D. Hunt, J. Parsons, 2007, Journal of Cell Science.

Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase.

J. Parsons, J. Hildebrand, M. Schaller, 1995, Molecular biology of the cell.

pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk

J. Parsons, M. Schaller, M D Schaller, 1995, Molecular and cellular biology.

Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase.

R L Juliano, J. Parsons, L. Kornberg, 1992, The Journal of biological chemistry.

Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors.

J. Parsons, J. Brugge, B. Haimovich, 1994, The Journal of biological chemistry.

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

J. Parsons, J. Fox, J. Hildebrand, 1994, Molecular and cellular biology.

Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex

J. Parsons, H. Wu, Hong Wu, 1993, The Journal of cell biology.

Identification and characterization of a novel cytoskeleton-associated pp60src substrate

J. Parsons, S. Kanner, A. Reynolds, 1991, Molecular and cellular biology.

Monoclonal antibodies specific for the virion polypeptide, p27, of avian retroviruses.

J. Parsons, D. Benjamin, S. Parsons, 1984, Hybridoma.

The Src pathway as a therapeutic strategy

J. Parsons, S. Parsons, Michelle L. Demory, 2005 .

Focal adhesion kinase: the first ten years

J. Parsons, J. Thomas Parsons, 2003, Journal of Cell Science.

Deletion mutant of the Bratislava-77 strain of Rous sarcoma virus containing a fusion of the group-specific antigen and envelope genes

J. Parsons, P. Highfield, P. Dierks, 1979, Journal of virology.

The nucleotide sequence complexity of avian tumor virus RNA.

M. Billeter, J. Parsons, J. Coffin, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Monoclonal Antibody Which Binds Both Amino and Carboxy Peptide Fragments of pp6OV-src

J. Parsons, D. Benjamin, S. Parsons, 2003 .

Mutations within the 5' half of the avian retrovirus MC29 v-myc gene alter or abolish transformation of chicken embryo fibroblasts and macrophages

J. Parsons, J. Huff, S. F. Farina, 1992, Journal of virology.

Monoclonal antibodies to Rous sarcoma virus pp60src react with enzymatically active cellular pp60src of avian and mammalian origin

J. Parsons, D. Benjamin, S. Parsons, 1984, Journal of virology.

Isolation and partial characterization of a monoclonal antibody to the Rous sarcoma virus transforming protein pp60src

J. Parsons, D. Benjamin, S. Parsons, 1983, Journal of virology.

Immune response to the src gene product in mice bearing tumors induced by injection of avian sarcoma virus-transformed mouse cells

J. Parsons, D. Benjamin, W. Kuehl, 1979, Journal of virology.

Expression of focal adhesion kinase in normal and pathologic human prostate tissues

H. Frierson, J. Parsons, R. Adams, 2002, The Prostate.

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

J. Parsons, M. Schaller, A. Reynolds, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Biochemical studies on adenovirus multiplication. 18. Resolution of early virus-specific RNA species in Ad 2 infected and transformed cells.

J. Parsons, M. Green, M. Green, 1969, Virology.

Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases.

J. Parsons, J. Hildebrand, M. Schaller, 1999, Molecular biology of the cell.

Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways.

J. Parsons, S. Parsons, 1997, Current opinion in cell biology.

A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK

J. Parsons, J. Thomas Parsons, Alan Richardson, 1996, Nature.

Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.

J. Parsons, T. J. Lansing, M. Weber, 1987, The EMBO journal.

The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro.

E Medico, J. Parsons, E. Medico, 1996, Molecular biology of the cell.

Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins.

J. Parsons, J Thomas Parsons, 1996, Current opinion in cell biology.

In vitro synthesis of Rous sarcoma virus-specific RNA is catalyzed by a DNA-dependent RNA polymerase.

J. Parsons, J. Coffin, C. Weissmann, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Quantitative Determination and Location of Newly Synthesized Virus-Specific Ribonucleic Acid in Chicken Cells Infected with Rous Sarcoma Virus

J. Parsons, J. Coffin, C. Weissmann, 1973, Journal of virology.

Transcription of Adenovirus Genes in Productively Infected and in Transformed Cells

J. Parsons, H. Caffier, K. Fujinaga, 1970 .

Cellular Characterization of a Novel Focal Adhesion Kinase Inhibitor*

Christopher Autry, J. Parsons, M. Iwanicki, 2007, Journal of Biological Chemistry.

Focal adhesion kinase as a regulator of cell tension in the progression of cancer.

J. Parsons, J Thomas Parsons, R. Tilghman, 2008, Seminars in cancer biology.

CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response

Mazhar Adli, Mazhar Adli, J. Parsons, 2018, Nature Communications.

Integrin connections map: to infinity and beyond.

J. Parsons, K. Martin, S. Boerner, 2002, Science.

HDAC6 modulates cell motility by altering the acetylation level of cortactin.

Sharon Y. R. Dent, J. Parsons, William Arbuthnot Sir Lane, 2007, Molecular cell.

Interplay between Oncogenes and Tumor Suppressor Genes in Human Disease

J. Parsons, S. Parsons, J. DaSilva, 2016 .

Induction of Apoptosis after Expression of PYK2, a Tyrosine Kinase Structurally Related to Focal Adhesion Kinase

J. Parsons, W. Xiong, 1997, The Journal of cell biology.

Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton.

J. Parsons, Michael S. Guerrero, A. Bouton, 2012, Genes & cancer.

Focal Adhesion Kinase: Targeting Adhesion Signaling Pathways for Therapeutic Intervention

J. Parsons, W. Roberts, R. Tilghman, 2008, Clinical Cancer Research.

Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate

J. Parsons, D. Flynn, A. Reynolds, 1993, Molecular and cellular biology.

Cell Migration--Movin' On

J. Parsons, A. R. Horwitz, 1999, Science.

Extracellular Signal-Regulated Kinase 2 (ERK2) Phosphorylation Sites and Docking Domain on the Nuclear Pore Complex Protein Tpr Cooperatively Regulate ERK2-Tpr Interaction

J. Parsons, W. R. Burack, M. Iwanicki, 2008, Molecular and Cellular Biology.

Cortactin Localization to Sites of Actin Assembly in Lamellipodia Requires Interactions with F-Actin and the Arp2/3 Complex

Alissa M. Weaver, A. Karginov, Andrew W. Kinley, 2000, The Journal of cell biology.

Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho.

J. Taylor, J. Parsons, M. Macklem, 1999, Journal of cell science.

An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase

J. Taylor, J. Parsons, J. Hildebrand, 1996, Molecular and cellular biology.

Chicken Macrophage Stimulating Protein Is a Ligand of the Receptor Protein-tyrosine Kinase Sea*

R. Wahl, J. Parsons, P. Courchesne, 1999, The Journal of Biological Chemistry.

The protooncogene c-sea encodes a transmembrane protein-tyrosine kinase related to the Met/hepatocyte growth factor/scatter factor receptor.

J. Parsons, T. J. Lansing, J. Huff, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Mitogen-Activated Protein Kinase Feedback Phosphorylation Regulates MEK1 Complex Formation and Activation during Cellular Adhesion

J. Parsons, A. Catling, S. T. Eblen, 2004, Molecular and Cellular Biology.

Emerging views of integrin signaling: Implications for prostate cancer

J. Parsons, Jill K. Slack-Davis, 2004, Journal of cellular biochemistry.

Clinical, Molecular and Genetic Validation of a Murine Orthotopic Xenograft Model of Pancreatic Adenocarcinoma Using Fresh Human Specimens

J. Parsons, E. Stelow, J. B. Stokes, 2013, PloS one.

Development of a multicellular pancreatic tumor microenvironment system using patient-derived tumor cells.

E. Petricoin, J. Parsons, J. Wulfkuhle, 2019, Lab on a chip.

Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase

J. Parsons, M. Vicente-Manzanares, A. Horwitz, 2007, The Journal of cell biology.

Mechanism of carcinogenesis by RNA tumor viruses. 3. Formation of RNA, DNA complex and duplex DNA molecules by the DNA polymerase (s) of avian myeloblastosis virus.

J. Parsons, K. Fujinaga, M. Green, 1970, Proceedings of the National Academy of Sciences of the United States of America.

Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton.

S. Weed, J. Parsons, E. Schaefer, 2003, Molecular biology of the cell.

Interaction of Cortactin and N-WASp with Arp2/3 Complex

Alissa M. Weaver, A. Karginov, J. Parsons, 2002, Current Biology.

Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1.

S. Weed, J. Parsons, Yunrui Du, 1998, Journal of cell science.

Arrangement of Integrated Avian Sarcoma Virus DNA Sequences Within the Cellular Genomes of Transformed and Revertant Mammalian Cells

C. J. Collins, J. Parsons, D. Boettiger, 1980, Journal of virology.

Analysis of cellular integration sites in avian sarcoma virus infected duck embryo cells

J. Parsons, T. Gilmer, 1979, Journal of virology.

Matrix Rigidity Regulates Cancer Cell Growth by Modulating Cellular Metabolism and Protein Synthesis

J. Parsons, J. Fox, N. Sherman, 2012, PloS one.

Integration of avian sarcoma virus DNA sequences in transformed mammalian cells.

C. J. Collins, J. Parsons, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Focal adhesion kinase and associated proteins.

J. Parsons, M. Schaller, 1994, Current opinion in cell biology.

SH2 domain specificity and activity modified by a single residue

Tony Pawson, Zhou Songyang, Lewis C. Cantley, 1994, Nature.

Focal adhesion kinase: structure and signalling

J. Parsons, J. Hildebrand, M. Schaller, 1994, Journal of Cell Science.

Localization of conserved and nonconserved epitopes within the Rous sarcoma virus-encoded src protein

J. Parsons, S. Parsons, D. McCARLEY, 1986, Journal of virology.

Site-directed point mutation in the src gene oF rous sarcoma virus results in an inactive src gene product

J. Parsons, D. Bryant, 1983, Journal of virology.

Inhibition of Focal Adhesion Kinase by PF-562,271 Inhibits the Growth and Metastasis of Pancreatic Cancer Concomitant with Altering the Tumor Microenvironment

J. Parsons, R. Hwang, E. Stelow, 2011, Molecular Cancer Therapeutics.

Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells

J. Parsons, N. Sergina, M. Iwanicki, 2005, Journal of Cell Science.

c-Raf-mediated Inhibition of Epidermal Growth Factor-stimulated Cell Migration*

J. Parsons, A. Catling, S. T. Eblen, 1999, The Journal of Biological Chemistry.

Co-Treatment with Panitumumab and Trastuzumab Augments Response to the MEK Inhibitor Trametinib in a Patient-Derived Xenograft Model of Pancreatic Cancer1

J. Parsons, E. Stelow, T. Bauer, 2014, Neoplasia.

Adhesion-induced tyrosine phosphorylation of the p130 src substrate.

S. Bockholt, J. Parsons, K. Burridge, 1995, Journal of cell science.

Signal transduction through integrins: A central role for focal adhesion kinase?

J. Parsons, A. Richardson, 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

Studies on the structure and synthesis of Rous sarcoma virus RNA.

M. Billeter, J. Parsons, J. Coffin, 1975, Cold Spring Harbor symposia on quantitative biology.

Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape.

Andrew W. Kinley, J. Parsons, P. Hou, 2003, Human molecular genetics.

Characterization of Graf, the GTPase-activating Protein for Rho Associated with Focal Adhesion Kinase

J. Parsons, J. Hildebrand, M. Cox, 1998, The Journal of Biological Chemistry.

Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.

J. Parsons, S. Kanner, A. Reynolds, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein.

J. Parsons, W. Xiong, M. Macklem, 1998, Journal of cell science.

Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: a role for paxillin tyrosine phosphorylation

J. Parsons, J. Hildebrand, A. Richardson, 1997, Molecular and cellular biology.

Biochemical studies on adenovirus multiplication, XIX. Resolution of late viral RNA species in the nucleus and cytoplasm.

J. Parsons, M. Green, J. Gardner, 1971, Proceedings of the National Academy of Sciences of the United States of America.

A Thirteen-Gene Expression Signature Predicts Survival of Patients with Pancreatic Cancer and Identifies New Genes of Interest

Jae K. Lee, J. Parsons, J. Parsons, 2014, PloS one.

Mutations within the 5' half of the avian retrovirus MC29 v-myc gene alter or abolish transformation of chicken embryo fibroblasts and macrophages

J. Parsons, J. Huff, S. F. Farina, 1992, Journal of virology.

Inhibition of the growth of patient-derived pancreatic cancer xenografts with the MEK inhibitor trametinib is augmented by combined treatment with the epidermal growth factor receptor/HER2 inhibitor lapatinib.

John T Parsons, J. Parsons, T. Gilmer, 2013, Neoplasia.

FAK phosphorylation sites mapped by mass spectrometry

J. Shabanowitz, D. Hunt, J. Parsons, 2005, Journal of Cell Science.

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

J. Parsons, A. Catling, S. T. Eblen, 2003, The Journal of cell biology.

Identification of a Novel Cortactin SH3 Domain-Binding Protein and Its Localization to Growth Cones of Cultured Neurons

S. Weed, J. Parsons, Yunrui Du, 1998, Molecular and Cellular Biology.

Avian Retrovirus pp32 DNA-Binding Protein I. Recognition of Specific Sequences on Retrovirus DNA Terminal Repeats

J. Parsons, D. Grandgenett, T. K. Misra, 1982, Journal of virology.

SRChing for the substrates of Src

S. Weed, J. Parsons, S. Kanner, 2014, Oncogene.

Cortactin phosphorylation sites mapped by mass spectrometry

J. Shabanowitz, D. Hunt, J. Parsons, 2006, Journal of Cell Science.

Modular domains of focal adhesion-associated proteins.

J. Taylor, J. Parsons, A. Richardson, 1998, Current topics in microbiology and immunology.

tyrosine phosphorylation. catalytically inactive FAK: a role for paxillin (FAK) is rescued by coexpression of Src or C-terminal domain of focal adhesion kinase Inhibition of cell spreading by expression of the

J. Parsons, J. Hildebrand, A. Richardson, 2013 .

Regulation of the oncogenic activity of the cellular src protein requires the correct spacing between the kinase domain and the C-terminal phosphorylated tyrosine (Tyr-527)

J. Parsons, A. Reynolds, B. S. Cobb, 1991, Molecular and cellular biology.

Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells

J. Olivo-Marin, A. Karginov, S. Weed, 2004, The Journal of cell biology.

RACK1 Targets the Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway To Link Integrin Engagement with Focal Adhesion Disassembly and Cell Motility

J. Parsons, H. Schaeffer, M. Iwanicki, 2007, Molecular and Cellular Biology.

Adjuvant Trametinib Delays the Outgrowth of Occult Pancreatic Cancer in a Mouse Model of Patient-Derived Liver Metastasis

J. Parsons, O. Rahma, E. Stelow, 2016, Annals of Surgical Oncology.

Focal adhesion kinase modulates activation of NF-kappaB by flow in endothelial cells.

J. Parsons, M. Schwartz, Cornelia S. Hahn, 2009, American journal of physiology. Cell physiology.

Local degradation of fibronectin at sites of expression of the transforming gene product pp60src

J. Parsons, S. Parsons, Wen‐Tien Chen, 1985, Nature.

A novel role for signal transducer and activator of transcription 5b (STAT5b) in β1-integrin-mediated human breast cancer cell migration

J. Parsons, Jessica Zareno, Corinne M. Silva, 2009, Breast Cancer Research.

Rapidly labeled messenger ribonucleic acid-protein complex of rat liver nuclei.

J. Parsons, K. McCarty, 1968, The Journal of biological chemistry.

Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells.

J. Parsons, J. Fox, N. Sherman, 2012, Journal of proteomics.

CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response

Mazhar Adli, J. Parsons, Cem Kuscu, 2018, Nature Communications.

The protein tyrosine kinase substrate cortactin is differentially expressed in murine B lymphoid tumors.

J. Parsons, T. Bender, M. Miglarese, 1994, Oncogene.

c-Src Tyrosine Phosphorylation of Epidermal Growth Factor Receptor, P190 RhoGAP, and Focal Adhesion Kinase Regulates Diverse Cellular Processes

J. Parsons, S. Parsons, J. K. Slack, 2001 .

c-Src tyrosine phosphorylation of epidermal growth factor receptor, P190 RhoGAP, and focal adhesion kinase regulates diverse cellular processes.

J. Parsons, S. Parsons, J. K. Slack, 2001, Chemical reviews.

Dynamin2 and Cortactin Regulate Actin Assembly and Filament Organization

A. Karginov, S. Weed, J. Parsons, 2002, Current Biology.

Expression and maturation of the cellular sea receptor, a member of the hepatocyte growth factor (HGF) receptor family of protein tyrosine kinases.

J. Parsons, T. Jamieson, J. Huff, 1996, Oncogene.

Regulation of the cellular src protein tyrosine kinase: interactions of the carboxyl terminal sequences residing between the kinase domain and tyrosine-527.

J. Parsons, B. S. Cobb, 1993, Oncogene.

Integrin-dependent Activation of the p70 Ribosomal S6 Kinase Signaling Pathway*

J. Parsons, R. K. Malik, Thomas Parsons¶i, 1996, The Journal of Biological Chemistry.

CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response

Mazhar Adli, J. Parsons, Cem Kuscu, 2018, Nature Communications.

Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase

J. Parsons, M. Vicente-Manzanares, A. Horwitz, 2007, The Journal of cell biology.

Activation of pp60c-src tyrosine kinase specific activity in tumor-derived Syrian hamster embryo cells.

J. Parsons, S. Kanner, T. Gilmer, 1988, Oncogene.

Construction of plasmids for expression of Rous sarcoma virus transforming protein, p60src, in Escherichia coli.

J. Parsons, T. Gilmer, R. Erikson, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Evaluation of SAS1B as a target for antibody-drug conjugate therapy in the treatment of pancreatic cancer

J. Parsons, C. Slingluff, W. Olson, 2018, Oncotarget.

CHAPTER 78 – Integrin Signaling: Cell Migration, Proliferation, and Survival

J. Parsons, K. Martin, R. Tilghman, 2003 .

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

J. Parsons, A. Catling, S. T. Eblen, 2003, The Journal of cell biology.

Structural and functional motifs of the Rous sarcoma virus src protein.

J. Parsons, S. Parsons, V. Wilkerson, 1986, Gene amplification and analysis.

Terminally repeated sequences in the avian sarcoma virus RNA genome.

J. Parsons, M. Collett, A. Faras, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Focal adhesion kinase modulates activation of NF-kappaB by flow in endothelial cells.

J. Parsons, M. Schwartz, Cornelia S. Hahn, 2009, American journal of physiology. Cell physiology.