N. Harada

N. Harada, H. Sasano, G. Matsunaga, 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Anatomical relationships between aromatase and tyrosine hydroxylase in the quail brain: Double‐label immunocytochemical studies

Gregory F Ball, N. Harada, J. Balthazart, 1998, The Journal of comparative neurology.

Human and quail aromatase activity is rapidly and reversibly inhibited by phosphorylating conditions.

N. Harada, J. Balthazart, C. Cornil, 2011, Endocrinology.

Behavioral Analysis of Genetically Modified Mice Indicates Essential Roles of Neurosteroidal Estrogen

N. Harada, T. Wakatsuki, S. Honda, 2011, Front. Endocrin..

Lack of estrogen increases pain in the trigeminal formalin model: a behavioural and immunocytochemical study of transgenic ArKO mice

N. Harada, J. Schoenen, Á. Párdutz, 2005, Pain.

Expression and cellular localization of estrogen receptors alpha and beta in the human fetus.

S. Inoue, N. Harada, H. Sasano, 2001, The Journal of clinical endocrinology and metabolism.

Regulation of aromatase cytochrome P-450 (estrogen synthetase) transcripts in the quail brain by testosterone.

N. Harada, J. Balthazart, A. Foidart, 1992, Brain research. Molecular brain research.

Synergism between androgens and estrogens in the induction of aromatase and its messenger RNA in the brain

N. Harada, J. Balthazart, A. Foidart, 1993, Brain Research.

Aromatase immunoreactivity in axon terminals of the vertebrate brain. An immunocytochemical study on quail, rat, monkey and human tissues.

C. Léránth, N. Harada, T. Horvath, 1996, Neuroendocrinology.

Rate-limiting steps in cytochrome P-450-catalysed reactions: studies on isotope effects in the O-de-ethylation of 7-ethoxycoumarin.

A. Y. Lu, N. Harada, G. Miwa, 1984, Xenobiotica; the fate of foreign compounds in biological systems.

Purification and characterization of four forms of cytochrome P-450 from liver microsomes of phenobarbital-treated and 3-methylcholanthrene-treated rats.

N. Harada, T. Omura, T. Miyata, 1984, Journal of biochemistry.

A GCM Motif Protein Is Involved in Placenta-specific Expression of Human Aromatase Gene*

N. Harada, S. Honda, T. Okazaki, 1999, The Journal of Biological Chemistry.

The alternative exons 1 of the mouse aromatase cytochrome P-450 gene.

N. Harada, S. Honda, Y. Takagi, 1996, Biochimica et biophysica acta.

Breast carcinoma in women over the age of 85: distinct histological pattern and androgen, oestrogen, and progesterone receptor status

N. Harada, F. Akiyama, M. Sawabe, 2003, Histopathology.

Localization and controls of aromatase in the quail spinal cord

N. Harada, P. Absil, J. Balthazart, 2000, The Journal of comparative neurology.

Ontogeny of Aromatase and Tyrosine Hydroxylase Activity and of Aromatase‐Immunoreactive Cells in the Preoptic Area of Male and Female Japanese Quail

N. Harada, J. Balthazart, O. Tlemçani, 2000, Journal of neuroendocrinology.

Neuroanatomical Distribution and Variations across the Reproductive Cycle of Aromatase Activity and Aromatase-Immunoreactive Cells in the Pied Flycatcher (Ficedula hypoleuca)

N. Harada, J. Balthazart, A. Foidart, 1998, Hormones and Behavior.

Localization of testosterone-sensitive and sexually dimorphic aromatase-immunoreactive cells in the quail preoptic area

N. Harada, J. Balthazart, O. Tlemçani, 1996, Journal of Chemical Neuroanatomy.

Novel properties of human placental aromatase as cytochrome P-450: purification and characterization of a unique form of aromatase.

N. Harada, 1988, Journal of biochemistry.

Immunocytochemical localization of aromatase in the brain

N. Harada, J. Balthazart, A. Foidart, 1990, Brain Research.

Neuroanatomical specificity in the co-localization of aromatase and estrogen receptors.

N. Harada, J. Balthazart, A. Foidart, 1991, Journal of neurobiology.

Neuroanatomical specificity in the autoregulation of aromatase-immunoreactive neurons by androgens and estrogens: an immunocytochemical study

N. Harada, J. Balthazart, F. Naftolin, 1992, Brain Research.

Synergistic control by androgens and estrogens of aromatase in the quail brain.

N. Harada, J. Balthazart, A. Foidart, 1994, Neuroreport.

Morphometric studies demonstrate that aromatase-immunoreactive cells are the main target of androgens and estrogens in the quail medial preoptic nucleus

N. Harada, J. Balthazart, A. Foidart, 1994, Experimental Brain Research.

Effects of steroidal and non steroidal aromatase inhibitors on sexual behavior and aromatase-immunoreactive cells and fibers in the quail brain

N. Harada, J. Balthazart, A. Foidart, 1994, Brain Research.

Co-localization of aromatase enzyme and estrogen receptor immunoreactivity in the preoptic area during reproductive aging

N. Harada, M. Ottinger, T. Dellovade, 1995, Brain Research.

Sex steroid hormones in pairs of tumor and serum from breast cancer patients and pathobiological role of androstene‐3β, 17β‐diol

N. Harada, S. Hayashi, K. Kuroi, 2011, Cancer science.

Participation of cytochrome P-450 in the reduction of nitro compounds by rat liver microsomes.

N. Harada, T. Omura, 1980, Journal of biochemistry.

Lack of association of ovariectomy-induced obesity with overeating and the reduction of physical activities

N. Harada, M. Nakatani, T. Wakatsuki, 2019, Biochemistry and biophysics reports.

N. Harada, N. Yoshimura, S. Murayama, 2017, Scientific Reports.

Relationships Between Aromatase Activity in the Brain and Gonads and Behavioural Deficits in Homozygous and Heterozygous Aromatase Knockout Mice

N. Harada, J. Balthazart, S. Honda, 2004, Journal of neuroendocrinology.

Distribution of aromatase-immunoreactive cells in the mouse forebrain

N. Harada, J. Balthazart, A. Foidart, 2004, Cell and Tissue Research.

Aromatase-immunoreactive cells are present in mouse brain areas that are known to express high levels of aromatase activity

N. Harada, J. Balthazart, A. Foidart, 1995, Cell and Tissue Research.

Inhibitors of aromatase prevent degradation of the enzyme in cultured human tumour cells.

N. Harada, O. Hatano, 1998, British Journal of Cancer.

Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years

N. Harada, N. Yoshimura, F. Akiyama, 2009, Breast Cancer Research.

Estrogen secreting adrenal adenocarcinoma in an 18-month-old boy: aromatase activity, protein expression, mRNA and utilization of gonadal type promoter.

N. Harada, N. Ohnuma, T. Matsunaga, 2000, Endocrine journal.

Aromatase and sex steroid receptors in human vena cava.

N. Harada, H. Sasano, H. Nagura, 1999, Endocrine journal.

Localized aberrant expression of cytochrome P450 aromatase in primary and metastatic malignant tumors of human liver.

N. Harada, N. Yoshimura, T. Katsuyama, 1998, The Journal of clinical endocrinology and metabolism.

Aromatase in hyperplasia and carcinoma of the human prostate

N. Harada, H. Sasano, M. Ozaki, 1997, The Prostate.

Aberrant expression of aromatase in breast cancer tissues

N. Harada, 1997, The Journal of Steroid Biochemistry and Molecular Biology.

Functional aromatase expression in porcine adrenal gland and testis.

N. Harada, E. Simpson, C. Corbin, 1996, Biology of reproduction.

Presence of alternatively spliced transcripts of aromatase gene in human breast cancer.

N. Harada, Y. Takagi, Y. Takagi, 1996, The Journal of clinical endocrinology and metabolism.

Aromatase mRNA Levels in Benign Prostatic Hyperplasia and Prostate Cancer

N. Harada, K. Tozawa, K. Kohri, 1996, International journal of urology : official journal of the Japanese Urological Association.

Aromatase cytochrome P450 gene expression in endometrial carcinoma.

K. Kaga, N. Harada, H. Sasano, 1996, British Journal of Cancer.

Short Communication Aromatase inHumanCommonEpithelial Ovarian Neoplasms

N. Harada, H. Sasano, M. Ozaki, 1996 .

Aromatase in human common epithelial ovarian neoplasms.

K. Kaga, N. Harada, H. Sasano, 1996, The American journal of pathology.

Pre- and post-translational regulation of aromatase by steroidal and non-steroidal aromatase inhibitors

N. Harada, J. Balthazart, A. Foidart, 1995, Brain Research.

Aromatase inhibitors and enzyme stability.

N. Harada, S. Honda, O. Hatano, 1999, Endocrine-related cancer.

COMPARATIVE BIOCHEMISTRY OF ANIMAL, PLANT, AND MICROORGANISM OXIDASES

N. Harada, T. Omura, H. Yoshioka, 1983 .

Immunochemical study on the role of different types of microsomal cytochrome P-450 in mutagenesis by chemical carcinogens.

M. Noshiro, N. Harada, H. Yonekawa, 1980, Cancer research.

Critical re-examination of the distribution of aromatase-immunoreactive cells in the quail forebrain using antibodies raised against human placental aromatase and against the recombinant quail, mouse or human enzyme

N. Harada, N. Yoshimura, J. Balthazart, 1995, Journal of Chemical Neuroanatomy.

Brain aromatase expression after experimental stroke: Topography and time course

A. Dominiczak, N. Harada, L. Garcia-Segura, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

Purification and characterization of a newly identified isoform of cytochrome P450 responsible for 3-hydroxylation of 2,5,2',5'-tetrachlorobiphenyl in hamster liver.

N. Harada, H. Yamada, Y. Ishii, 1995, Archives of biochemistry and biophysics.

Structure, Regulation and Polymorphisms of the Aromatase Gene

N. Harada, 2015 .

Mouse liver testosterone 16 alpha-hydroxylase (cytochrome P-450(16) alpha). Purification, regioselectivity, stereospecificity, and immunochemical characterization.

N. Harada, M. Negishi, 1984, The Journal of biological chemistry.

Changes in the Arginine‐Vasopressin Immunoreactive Systems in Male Mice Lacking a Functional Aromatase Gene

N. Harada, P. Absil, J. Balthazart, 2002, Journal of neuroendocrinology.

Accelerated conversion of dehydroepiandrosterone sulfate to estrogen in a patient with Crow-Fukase syndrome and diabetes mellitus.

N. Harada, A. Nagasaka, M. Itoh, 1999, Endocrine research.

Molecular cloning of human UMP synthase.

N. Harada, K. Okajima, Y. Wada, 1988, Advances in experimental medicine and biology.

Immunochemical study on the participation of cytochrome b5 in drug oxidation reactions of mouse liver microsomes.

M. Noshiro, N. Harada, T. Omura, 1979, Biochemical and biophysical research communications.

The Aromatase Knock-Out Mouse Provides New Evidence That Estradiol Is Required during Development in the Female for the Expression of Sociosexual Behaviors in Adulthood

N. Harada, J. Balthazart, S. Honda, 2002, The Journal of Neuroscience.

[A new aspect of the pharmacological and physiological significance of the aromatase/estrogen system].

N. Harada, 1998, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Ontogeny of aromatase messenger ribonucleic acid in mouse brain: fluorometrical quantitation by polymerase chain reaction.

N. Harada, K. Yamada, 1992, Endocrinology.

Aromatase knockout mice reveal an impact of estrogen on drug-induced alternation of murine electrocardiography parameters.

N. Harada, T. Furukawa, S. Honda, 2015, The Journal of toxicological sciences.

Unique regulation of expression of human aromatase in the placenta

N. Harada, N. Yoshimura, S. Honda, 2003, The Journal of Steroid Biochemistry and Molecular Biology.

17β-Hydroxysteroid dehydrogenase type 2 expression and enzyme activity in the human gastrointestinal tract

N. Harada, Takashi Suzuki, H. Sasano, 2001 .

LIM‐Homeodomain Transcription Factor, Lhx2, is involved in Transcriptional Control of Brain‐Specific Promoter/Exon 1f of the Mouse Aromatase Gene

N. Harada, S. Honda, S. Soeda, 2012, Journal of neuroendocrinology.

Aromatase and Intracrinology of Estrogen in Hormone-Dependent Tumors

N. Harada, 1999, Oncology.

Aromatase and 17 beta-hydroxysteroid dehydrogenase type 1 in human breast carcinoma.

N. Harada, M. Poutanen, H. Sasano, 1996, The Journal of clinical endocrinology and metabolism.

Forskolin increases the effect of everolimus on aromatase inhibitor-resistant breast cancer cells

N. Harada, T. Wakatsuki, J. Yukitake, 2018, Oncotarget.

Estradiol suppresses phosphorylation of ERα serine 167 through upregulation of PP2A in breast cancer cells.

N. Harada, J. Yukitake, T. Utsumi, 2017, Oncology letters.

Biochemical and molecular genetic analyses on placental aromatase (P-450AROM) deficiency.

N. Harada, E. Nishida, Y. Takagi, 1992, The Journal of biological chemistry.

Insulin-like growth factor I enhances the expression of aromatase P450 by inhibiting autophagy.

N. Harada, Bo Zhang, H. Ishikawa, 2010, Endocrinology.

Demonstration of aromatase activity and its regulation in breast tumor and benign breast fibroblasts

N. Harada, R. Santen, R. Zaino, 2004, Breast Cancer Research and Treatment.

Core glycosylation of cytochrome P-450(arom). Evidence for localization of N terminus of microsomal cytochrome P-450 in the lumen.

N. Harada, K. Mihara, M. Sakaguchi, 1993, The Journal of biological chemistry.

Activation of Peroxisome Proliferator-Activated Receptor-γ and Retinoid X Receptor Inhibits Aromatase Transcription via Nuclear Factor-κB

N. Harada, T. Yanase, H. Nawata, 2005 .

Upregulation of CIP2A in estrogen depletion‐resistant breast cancer cells treated with low‐dose everolimus

N. Harada, Y. Shimono, Takuma Fujii, 2020, FEBS open bio.

HMGA1a Induces Alternative Splicing of the Estrogen Receptor-αlpha Gene by Trapping U1 snRNP to an Upstream Pseudo-5′ Splice Site

N. Harada, K. Ohe, A. Mayeda, 2018, Front. Mol. Biosci..

Molecular cloning of a cDNA encoding human histidase.

N. Harada, Y. Wada, Y. Takagi, 1993, Biochimica et biophysica acta.

Estrogen-dependent regulation of the expression of hepatic Cyp2b and 3a isoforms: assessment using aromatase-deficient mice.

N. Harada, S. Honda, T. Hara, 2002, Toxicology and applied pharmacology.

Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects.

N. Harada, T. Horvath, G. Mor, 1999, Menopause.

Expression of estrogen synthetase (P-450 aromatase) during adipose differentiation of 3T3-L1 cells.

N. Harada, K. Yamada, 1990, Biochemical and biophysical research communications.

Pathway in Human Breast Cancer Tumor-Stromal Interaction through the Estrogen-Signaling

N. Harada, M. Kurosumi, K. Suemasu, 2005 .

Inhibition of PP2A in MCF-7 cells leads to hormone-independent growth

N. Harada, J. Yukitake, T. Utsumi, 2016 .

Depression in gene expression for poly(ADP-ribose) synthetase during the interferon-gamma-induced activation process of murine macrophage tumor cells.

N. Harada, S. Takahashi, T. Yamamoto, 1988, European journal of biochemistry.

Isolation of a cDNA Clone Encoding Bovine Poly(ADP-Ribose) Synthetase by Immunological Screening of a cDNA Expression Library and its Application as a Probe

N. Harada, Hiroshi Yamamoto, K. Yamauchi, 1989 .

Reciprocal expression of 17alpha-hydroxylase-C17,20-lyase and aromatase cytochrome P450 during bovine trophoblast differentiation: a two-cell system drives placental oestrogen synthesis.

N. Harada, B. Hoffmann, A. Conley, 2006, Reproduction.

Genetic studies to characterize the origin of the mutation in placental aromatase deficiency.

N. Harada, M. Shozu, K. Yamada, 1992, American journal of human genetics.

Expression cloning of a cDNA encoding a novel murine B cell activation marker. Homology to human CD38.

N. Harada, N. Copeland, N. Jenkins, 1993, Journal of immunology.

Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene.

N. Harada, S. Honda, Y. Takagi, 1998, Biochemical and biophysical research communications.

Aromatase Controls Sjögren ’ s Syndrome-like Lesions through MCP-1 in Target Organ and Adipose Tissue-Associated Macrophages

N. Harada, N. Yoshimura, N. Ishimaru, 2019 .

Aromatase controls Sjögren syndrome-like lesions through monocyte chemotactic protein-1 in target organ and adipose tissue-associated macrophages.

N. Harada, N. Yoshimura, N. Ishimaru, 2015, The American journal of pathology.

Estrogen receptor-independent catechol estrogen binding activity: protein binding studies in wild-type, Estrogen receptor-alpha KO, and aromatase KO mice tissues.

N. Harada, D. Lubahn, G. Rottinghaus, 2004, Biochemistry.

Dietary Isothiocyanates Modify Mitochondrial Functions through Their Electrophilic Reaction

N. Harada, Yoshimasa Nakamura, K. Kawai, 2005, Bioscience, biotechnology, and biochemistry.

Protective Effect of Brazilian Propolis against Liver Damage with Cholestasis in Rats Treated with α-Naphthylisothiocyanate

N. Harada, K. Ohashi, K. Tokunaga, 2013, Evidence-based complementary and alternative medicine : eCAM.

Protective Effect of Brazilian Propolis Against Hepatic Oxidative Damage in Rats with Water‐immersion Restraint Stress

N. Harada, K. Ohashi, K. Tokunaga, 2012, Phytotherapy research : PTR.

Change in hepatic antioxidant defense system with liver injury development in rats with a single alpha-naphthylisothiocyanate intoxication.

N. Harada, Y. Ohta, M. Kongo, 1999, Toxicology.

Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects

N. Harada, T. Horvath, G. Mor, 2018, Menopause.

Calcineurin and CRTC2 mediate FSH and TGFβ1 upregulation of Cyp19a1 and Nr5a in ovary granulosa cells.

N. Harada, Peng-Hui Wang, Wen-Ling Lee, 2014, Journal of molecular endocrinology.

Calcineurin and CRTC 2 mediate FSH and TGF b 1 upregulation of Cyp 19 a 1 and Nr 5 a in ovary granulosa cells

N. Harada, Peng-Hui Wang, Wen-Ling Lee, 2014 .

17β-Hydroxysteroid Dehydrogenase Type 1 and 2 Expression in the Human Fetus1

N. Harada, Takashi Suzuki, H. Sasano, 2000 .

Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders.

N. Harada, H. Sasano, H. Nagura, 1994, Human pathology.

Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions: full expression of the intrinsic isotope effect during the O-deethylation of 7-ethoxycoumarin by liver microsomes from 3-methylcholanthrene-induced hamsters.

A. Y. Lu, N. Harada, G. Miwa, 1985, Archives of biochemistry and biophysics.

Aromatase and estrogen receptor beta expression in the rat olfactory bulb: Neuroestrogen action in the first relay station of the olfactory pathway?

N. Harada, Á. Párducz, L. Siklós, 2014, Acta neurobiologiae experimentalis.

Novel exon 1 of the aromatase gene specific for aromatase transcripts in human brain.

N. Harada, S. Honda, Y. Takagi, 1994, Biochemical and biophysical research communications.

Effects of changes in gonadal hormones on the amount of aromatase messenger RNA in mouse brain diencephalon.

N. Harada, Y. Takagi, M. Tamaru, 1993, Biochemical and biophysical research communications.

Cytochrome P450 aromatase expression in canine nervous tissue: an immunohistochemical study.

N. Harada, S. Karahan, M. Yarım, 2008, Polish journal of veterinary sciences.

Selective induction of two different molecular species of cytochrome P-450 by phenobarbital and 3-methylcholanthrene.

N. Harada, T. Omura, 1981, Journal of biochemistry.

Forebrain Fos responses to reproductively related chemosensory cues in aromatase knockout mice

N. Harada, S. Honda, N. Aste, 2003, Brain Research Bulletin.

Expression and transport into mitochondria of bovine cytochrome P-450(SCC) in insect cells using the baculovirus expression system.

N. Harada, Y. Takagi, H. Shimada, 1992, Biochemical and biophysical research communications.

Immunoelectron microscopic localization of aromatase in human placenta and ovary using microwave fixation.

N. Harada, H. Ohtani, H. Nagura, 1990, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Aromatase expression in the brain of the ruffed grouse (Bonasa umbellus) and comparisons with other galliform birds (Aves, Galliformes)

N. Harada, A. Iwaniuk, Jeremy R. Corfield, 2013, Journal of Chemical Neuroanatomy.

Mode of Action and Functional Significance of Estrogen-Inducing Dendritic Growth, Spinogenesis, and Synaptogenesis in the Developing Purkinje Cell

N. Harada, K. Tsutsui, S. Honda, 2007, The Journal of Neuroscience.

An association between lipid peroxidation and alpha-naphthylisothiocyanate-induced liver injury in rats.

N. Harada, K. Nishida, Y. Ohta, 1999, Toxicology letters.

Cloning of a complete cDNA encoding human aromatase: immunochemical identification and sequence analysis.

N. Harada, N Harada, 1988, Biochemical and biophysical research communications.

Localized aberrant expression of cytochrome P450 aromatase in primary and metastatic malignant tumors of human liver.

N. Harada, N. Yoshimura, T. Katsuyama, 1998, The Journal of clinical endocrinology and metabolism.

Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis.

N. Harada, Y. Takagi, T. Utsumi, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Identification of a Polymyxin Produced by a Symbiotic Microorganism Isolated from the Brown Planthopper, Nilaparavata lugens

N. Harada, H. Kita, Y. Jigami, 1986 .

1-(2,4-Dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylpheny)propane inhibits melanin synthesis by dual mechanisms.

N. Harada, K. Wakamatsu, S. Ito, 2011, Journal of dermatological science.

The Analyses of 17β-Hydroxysteroid Dehydrogenase Isozymes in Human Endometrial Hyperplasia and Carcinoma1

N. Harada, Takashi Suzuki, H. Sasano, 2001 .

Immunohistochemical localization of steroidogenic enzymes and prolactin receptors in the corpus luteum and placenta of spotted seals (Phoca largha) during late pregnancy.

N. Harada, Masatsugu Suzuki, N. Ohtaishi, 2002, The Journal of veterinary medical science.

Intratumoral aromatase in human breast, endometrial, and ovarian malignancies.

N. Harada, H. Sasano, Nobuhiro Harada, 1998, Endocrine reviews.

Sexual Partner Preference Requires a Functional Aromatase (Cyp19) Gene in Male Mice

N. Harada, J. Balthazart, S. Honda, 2002, Hormones and Behavior.

Regulation of progestin receptors in medial amygdala: Estradiol, phytoestrogens and sex

N. Harada, S. Honda, A. Kudwa, 2009, Physiology & Behavior.

Effects of Organisational Oestradiol on Adult Immunoreactive Oestrogen Receptors (α and β) in the Male Mouse Brain

N. Harada, S. Honda, A. Kudwa, 2007 .

Immunocytochemical localization of aromatase in sensory and integrating nuclei of the hindbrain in Japanese quail (Coturnix japonica)

N. Harada, J. Balthazart, H. Evrard, 2004, The Journal of comparative neurology.

The Androgen Receptor Governs the Execution, but Not Programming, of Male Sexual and Territorial Behaviors

N. Harada, N. Shah, Melody V. Wu, 2010, Neuron.

Regulation of Placenta-specific Expression of the Aromatase Cytochrome P-450 Gene

N. Harada, S. Honda, Y. Takagi, 1995, The Journal of Biological Chemistry.

Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons.

J. Morrison, N. Harada, W. Janssen, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Intrinsic Function of the Aryl Hydrocarbon (Dioxin) Receptor as a Key Factor in Female Reproduction

Masayuki Yamamoto, N. Harada, Y. Fujii‐Kuriyama, 2005, Molecular and Cellular Biology.

Elevated steroid sulfatase expression in breast cancers

N. Harada, N. Yoshimura, S. Takeuchi, 2000, The Journal of Steroid Biochemistry and Molecular Biology.

Steroid sulfatase expression is an independent predictor of recurrence in human breast cancer.

N. Harada, N. Yoshimura, S. Takeuchi, 1999, Cancer research.

Recurrence in Human Breast Cancer Steroid Sulfatase Expression Is an Independent Predictor of Updated

N. Harada, N. Yoshimura, S. Takeuchi, 1999 .

Significance of steroid sulfatase expression in human breast cancer

N. Harada, N. Yoshimura, S. Takeuchi, 1999, Breast cancer.

Genetic analysis of human placental aromatase deficiency

N. Harada, 1993, The Journal of Steroid Biochemistry and Molecular Biology.

Correlation of cyclin D1 mRNA levels with clinico‐pathological parameters and clinical outcome in human breast carcinomas

N. Harada, N. Yoshimura, S. Takeuchi, 2000, International journal of cancer.

Incomplete testicular feminization syndrome: studies on androgen receptor(AR) function, AR gene analysis, and aromatase activities at puberty and long-term observations of clinical and hormonal features from infancy to puberty.

N. Harada, H. Mori, H. Nawata, 1996, Endocrine journal.

The Japanese quail: a model for studying reproductive aging of hypothalamic systems

N. Harada, G. Panzica, M. Ottinger, 2004, Experimental Gerontology.

The Proportion of Chromatin Graded between Closed and Open States Determines the Level of Transcripts Derived from Distinct Promoters in the CYP19 Gene

N. Harada, S. Ishihara, N. Kotomura, 2015, PloS one.

N. Harada, D. Maysinger, M. Sairam, 2003, Experimental Neurology.

Targeting steroid receptor coactivator-1 expression with locked nucleic acids antisense reveals different thresholds for the hormonal regulation of male sexual behavior in relation to aromatase activity and protein expression

N. Harada, G. Ball, J. Balthazart, 2006, Behavioural Brain Research.

Distribution and steroid dependence of aromatase enzyme immunoreactivity in limbic nuclei of the female musk shrew brain

N. Harada, T. Dellovade, E. Rissman, 1994, Brain Research.

Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis

N. Harada, K. Tsutsui, S. Haraguchi, 2014, Nature Communications.

Effects of testosterone and its metabolites on aromatase-immunoreactive cells in the quail brain: Relationship with the activation of male reproductive behavior

N. Harada, P. Absil, J. Balthazart, 1996, The Journal of Steroid Biochemistry and Molecular Biology.

Expression level of enzymes related to in situ estrogen synthesis and clinicopathological parameters in breast cancer patients

N. Harada, S. Akinaga, Y. Shiotsu, 2009, The Journal of Steroid Biochemistry and Molecular Biology.

Immunolocalization of steroidogenic enzymes in the corpus luteum and placenta of the Japanese black bear, Ursus thibetanus japonicus, during pregnancy.

N. Harada, J. Mason, S. Kominami, 2001, Reproduction.

Genetic Targeting Aromatase in Male Amyloid Precursor Protein Transgenic Mice Down-Regulates β-Secretase (BACE1) and Prevents Alzheimer-Like Pathology and Cognitive Impairment

Rena Li, N. Harada, M. Staufenbiel, 2010, The Journal of Neuroscience.

Inhibition of rat liver tryptophan pyrrolase activity and elevation of brain tryptophan concentration by administration of DL-alpha-amino-beta-pyridinepropanoic acid (pyridylalanine) analogs.

N. Harada, H. Shimeno, A. Toda, 1987, Journal of enzyme inhibition.

Intraovarian immunolocalization of steroidogenic enzymes in a Hokkaido brown bear, Ursus arctos yesoensis during the mating season.

N. Harada, J. Mason, S. Kominami, 1996, The Journal of veterinary medical science.

Molecular and epidemiological analyses of abnormal expression of aromatase in breast cancer.

N. Harada, Y. Takagi, T. Utsumi, 1995, Pharmacogenetics.

Distribution of aromatase immunoreactivity in the forebrain of red-sided garter snakes at the beginning of the winter dormancy

N. Harada, J. Balthazart, Daniel D. Baleckaitis, 2002, Journal of Chemical Neuroanatomy.

Distribution of aromatase-immunoreactive cells in the forebrain of zebra finches (Taeniopygia guttata): implications for the neural action of steroids and nuclear definition in the avian hypothalamus.

Gregory F Ball, N. Harada, P. Absil, 1996, Journal of neurobiology.

Distribution and sex differences in aromatase-producing neurons in the brain of Japanese quail embryos

N. Harada, N. Saito, Yumi Watanabe, 2010, Journal of Chemical Neuroanatomy.

Presence of aromatase and estrogen receptor alpha in the inner ear of zebra finches

N. Harada, G. Ball, J. Balthazart, 2009, Hearing Research.

Distribution and effects of testosterone on aromatase mRNA in the quail forebrain: A non-radioactive in situ hybridization study

N. Harada, J. Balthazart, G. Panzica, 1998, Journal of Chemical Neuroanatomy.

Aromatase-immunoreactive cells in the quail brain: Effects of testosterone and sex dimorphism

N. Harada, J. Balthazart, A. Foidart, 1994, Physiology & Behavior.

Aromatase as a cellular marker of testosterone action in the preoptic area

N. Harada, J. Balthazart, C. Surlemont, 1992, Physiology & Behavior.

Porcine Hypothalamic Aromatase Cytochrome P450: Isoform Characterization, Sex-Dependent Activity, Regional Expression, and Regulation by Enzyme Inhibition in Neonatal Boars1

N. Harada, B. Trainor, C. Corbin, 2009, Biology of reproduction.

Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.

N. Harada, M. Negishi, B. Burkhart, 1985, The Journal of biological chemistry.

Expression of synthetic human-lysozyme gene in Saccharomyces cerevisiae: use of a synthetic chicken-lysozyme signal sequence for secretion and processing.

N. Harada, H. Tanaka, Y. Jigami, 1986, Gene.

Expression of synthetic human lysozyme gene in Escherichia coli.

N. Harada, Y. Jigami, M. Muraki, 1985 .

Aromatase in atherosclerotic lesions of human aorta

N. Harada, H. Sasano, H. Murakami, 2001, The Journal of Steroid Biochemistry and Molecular Biology.

Analysis of Estrogen Receptor α and β in Endometrial Carcinomas: Correlation with ERβ and Clinicopathologic Findings in 45 Cases

N. Harada, Takashi Suzuki, H. Sasano, 2000 .

Expression and Cellular Localization of Estrogen Receptors α and β in the Human Fetus1

S. Inoue, N. Harada, Takashi Suzuki, 2001 .

Brain Endogenous Estrogen Levels Determine Responses to Estrogen Replacement Therapy via Regulation of BACE1 and NEP in Female Alzheimer’s Transgenic Mice

Rena Li, N. Harada, M. Staufenbiel, 2013, Molecular Neurobiology.

Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model.

Rena Li, N. Harada, M. Staufenbiel, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Phenobarbital- and 3-methylcholanthrene-induced synthesis of two different molecular species of microsomal cytochrome P-450 in rat liver.

N. Harada, T. Omura, 1983, Journal of biochemistry.

A unique aromatase (P-450AROM) mRNA formed by alternative use of tissue-specific exons 1 in human skin fibroblasts.

N. Harada, 1992, Biochemical and biophysical research communications.

Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies.

N. Harada, H. Sasano, M. Ozaki, 1995, The American journal of pathology.

From endocrinology to intracrinology

N. Harada, Takashi Suzuki, H. Sasano, 1998, Endocrine pathology.

International Congress on Hormonal Steroids and Hormones and Cancer New approaches to the understanding of tamoxifen action and resistance

N. Harada, M. Shanabrough, R. Santen, 2003 .

Specific innervation of aromatase neurons by substance P fibers in the dorsal horn of the spinal cord in quail

N. Harada, J. Balthazart, H. Evrard, 2003, The Journal of comparative neurology.

Genetic susceptibility and environmental estrogen-like compounds.

A. Børresen-Dale, V. Kristensen, N. Harada, 2001, Mutation research.

Genetic variants of CYP19 (aromatase) and breast cancer risk

P. Lønning, A. Børresen-Dale, N. Harada, 2000, Breast Cancer Research.

Expression of oestrogen receptor‐β in apocrine carcinomas of the breast

N. Harada, N. Yoshimura, F. Akiyama, 2007 .

Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications.

Vessela N Kristensen, Therese Sørlie, Anita Langerød, 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

Stromal spindle cells contain aromatase in human breast tumors.

N. Harada, R. Santen, R. Zaino, 1994, The Journal of clinical endocrinology and metabolism.

Effects of anastrozole on the intratumoral gene expression in locally advanced breast cancer

A. Frigessi, I. Glad, T. Sørlie, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

Oestrogen receptor‐β1 but not oestrogen receptor‐βcx is of prognostic value in apocrine carcinoma of the breast

N. Harada, F. Akiyama, R. Horii, 2008, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Semi-quantitative immunohistochemical analysis of aromatase expression in ductal carcinoma in situ of the breast

N. Harada, T. Toyama, H. Yamashita, 2002, Breast Cancer Research and Treatment.

Protective effect of melatonin against α‐naphthylisothiocyanate‐induced liver injury in rats

N. Harada, Y. Ohta, M. Kongo, 2000, Journal of pineal research.

Concomitant treatment of severe uterine adenomyosis in a premenopausal woman with an aromatase inhibitor and a gonadotropin-releasing hormone agonist.

N. Harada, Y. Noda, F. Kimura, 2007, Fertility and sterility.

Inhibitory action of Oren-gedoku-to extract on enzymatic lipid peroxidation in rat liver microsomes.

N. Harada, Y. Ohta, T. Hayashi, 2001, Biological & pharmaceutical bulletin.

Molecular analysis of aberrant expression of aromatase in breast cancer tissues

N. Harada, S. Honda, 2004, Breast Cancer Research and Treatment.

Analysis of transcriptional regulation of human breast aromatase by in vitro and in vivo studies

N. Harada, N. Yoshimura, Takahiro Matsumoto, 2001, The Journal of Steroid Biochemistry and Molecular Biology.

Macrophages, estrogen and the microenvironment of breast cancer

N. Harada, G. Mor, Ji-ping Wang, 1998, The Journal of Steroid Biochemistry and Molecular Biology.

Immunohistochemical localization of steroidogenic enzymes in the corpus luteum and the placenta of the ribbon seal (Phoca fasciata) and steller sea lion (Eumetopias jubatus).

N. Harada, N. Ohtaishi, J. Mason, 2001, The Journal of veterinary medical science.

The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 1999 by The Endocrine Society Aromatase Deficiency Caused by a Novel P450 arom Gene Mutation: Impact of Absent Estrogen Production on Serum Gonadotropin Concentration in a Bo

N. Harada, C. Flück, P. Mullis, 2022 .

Loss of aromatase cytochrome P450 function as a risk factor for Parkinson's disease?

N. Harada, C. Tirolo, S. Caniglia, 2008, Brain Research Reviews.

Autonomous expression of aromatase during development of mouse brain is modulated by neurotransmitters

N. Harada, Y. Takagi, S. Abe-Dohmae, 1997, The Journal of Steroid Biochemistry and Molecular Biology.

HMGA1a induces alternative splicing of estrogen receptor alpha in MCF-7 human breast cancer cells

N. Harada, K. Ohe, A. Mayeda, 2018, The Journal of Steroid Biochemistry and Molecular Biology.

The analyses of 17beta-hydroxysteroid dehydrogenase isozymes in human endometrial hyperplasia and carcinoma.

N. Harada, H. Sasano, S. Sato, 2001, The Journal of clinical endocrinology and metabolism.

Characterization of testosterone 16 alpha-hydroxylase (I-P-450(16) alpha) induced by phenobarbital in mice.

N. Harada, M. Negishi, K. Devore, 1985, Biochemistry.

Aromatase immunoreactivity in the rat brain: Gonadectomy-sensitive hypothalamic neurons and an unresponsive “limbic ring” of the lateral septum-bed nucleus-amygdala complex

C. Léránth, N. Harada, T. Horvath, 1993, The Journal of Steroid Biochemistry and Molecular Biology.

Cell type- and region-specific expression of aromatase mRNA in cultured brain cells.

N. Harada, S. Abe-Dohmae, R. Tanaka, 1994, Brain research. Molecular brain research.

RETRACTED: Neurological effects of aromatase deficiency in the mouse

N. Harada, Takahiro Matsumoto, S. Honda, 2003, The Journal of Steroid Biochemistry and Molecular Biology.

The characteristics of aromatase deficient hairless mice indicate important roles of extragonadal estrogen in the skin

N. Harada, A. Ohuchi, T. Kitahara, 2008, The Journal of Steroid Biochemistry and Molecular Biology.

Genetic Studies toCharacterize theOrigin oftheMutation in Placental AromataseDeficiency

N. Harada, H. Ogawa, 1992 .

Expression of aromatase CYP19 and its relationship with parameters in NSCLC.

N. Harada, T. Oyama, K. Sugio, 2009, Frontiers in bioscience.

Alteration in Sex-Specific Behaviors in Male Mice Lacking the Aromatase Gene

N. Harada, Takahiro Matsumoto, S. Honda, 2003, Neuroendocrinology.

DISTRIBUTION OF ELECTRON TRANSFER COMPONENTS ON THE SURFACE OF MICROSOMAL MEMBRANE

M. Noshiro, N. Harada, T. Omura, 1980 .

Mutations in the aromatase gene and their effect.

N. Harada, M. Shozu, K. Akasofu, 1992, Fertility and sterility.

17 beta-Hydroxysteroid dehydrogenase type 2 expression and enzyme activity in the human gastrointestinal tract.

N. Harada, H. Sasano, T. Shimosegawa, 2001, Clinical science.

Mouse liver testosterone 15 alpha-hydroxylase (cytochrome P-450(15) alpha). Purification, regioselectivity, stereospecificity, and sex-dependent expression.

N. Harada, M. Negishi, 1984, The Journal of biological chemistry.

Bcl-2 gene is highly expressed during neurogenesis in the central nervous system.

N. Harada, K. Yamada, Kazuo Yamada, 1993, Biochemical and biophysical research communications.

Adrenocortical and gonadal expression of the mammalian Ftz-F1 gene encoding Ad4BP/SF-1 is independent of pituitary control.

N. Harada, H. Nawata, K. Morohashi, 1998, Journal of biochemistry.

Post‐translational dual regulation of cytochrome P450 aromatase at the catalytic and protein levels by phosphorylation/dephosphorylation

N. Harada, Takanori Hayashi, 2014, The FEBS Journal.

In vitro increase of aromatase mRNA in diencephalic neurons.

N. Harada, Y. Takagi, S. Abe-Dohmae, 1996, Neuroendocrinology.

Baculovirus mediated high level expression of human placental aromatase (CYP19A1).

N. Harada, M. Titus, S. Nelson, 1994, Biochemical and biophysical research communications.

Estradiol Promotes Purkinje Dendritic Growth, Spinogenesis, and Synaptogenesis During Neonatal Life by Inducing the Expression of BDNF

N. Harada, K. Tsutsui, S. Honda, 2012, The Cerebellum.

Functional Analysis of Neurosteroidal Oestrogen Using Gene‐Disrupted and Transgenic Mice

N. Harada, N. Yoshimura, T. Wakatsuki, 2009, Journal of neuroendocrinology.

[The structural and functional characterization of P-450.aromatase (estrogen synthetase)].

N. Harada, 1992, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

17beta-hydroxysteroid dehydrogenase type 1 and 2 expression in the human fetus.

N. Harada, H. Sasano, H. Nagura, 2000, The Journal of clinical endocrinology and metabolism.

Impairment of spatial learning by estradiol treatment in female mice is attenuated by estradiol exposure during development

N. Harada, H. Bateman, S. Honda, 2006, Hormones and Behavior.

Analysis of spatiotemporal regulation of aromatase in the brain using transgenic mice

N. Harada, S. Honda, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

Identification of cis-acting elements in the proximal promoter region for brain-specific exon 1 of the mouse aromatase gene.

N. Harada, S. Honda, Y. Takagi, 1999, Brain research. Molecular brain research.

Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions. Evidence for the irreversible formation of an activated oxygen intermediate of cytochrome P-448.

A. Y. Lu, N. Harada, J. Walsh, 1984, The Journal of biological chemistry.

Neurotransmitter‐Mediated Regulation of Brain Aromatase: Protein Kinase C‐ and G‐Dependent Induction

N. Harada, Y. Takagi, S. Abe-Dohmae, 1996, Journal of neurochemistry.

Effects of organisational oestradiol on adult immunoreactive oestrogen receptors (alpha and beta) in the male mouse brain.

N. Harada, S. Honda, A. Kudwa, 2007, Journal of neuroendocrinology.

N. Harada, N. Yoshimura, S. Murayama, 2017, Scientific Reports.

Immunochemical study on the route of electron transfer from NADH and NADPH to cytochrome P-450 of liver microsomes.

M. Noshiro, N. Harada, T. Omura, 1980, Journal of Biochemistry (Tokyo).

[Aromatase deficiency].

N. Harada, 2004, Nihon rinsho. Japanese journal of clinical medicine.

Analysis of estrogen receptor alpha and beta in endometrial carcinomas: correlation with ER beta and clinicopathologic findings in 45 cases.

N. Harada, H. Sasano, S. Sato, 2000, International Journal of Gynecological Pathology.

Local modulation of steroid action: rapid control of enzymatic activity

N. Harada, J. Balthazart, O. Kah, 2015, Front. Neurosci..

Neurological effects of aromatase deficiency in the mouse.

N. Harada, Takahiro Matsumoto, S. Honda, 2003, The Journal of steroid biochemistry and molecular biology.

Sex Differences in Brain Aromatase Activity: Genomic and Non-Genomic Controls

N. Harada, G. Ball, J. Balthazart, 2011, Front. Endocrin..

Sex-dependent expression of mouse testosterone 16 alpha-hydroxylase (cytochrome P-450(16) alpha): cDNA cloning and pretranslational regulation.

N. Harada, M. Negishi, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Post‐translational dual regulation of cytochrome P450 aromatase at the catalytic and protein levels by phosphorylation/dephosphorylation

N. Harada, Takanori Hayashi, 2014, The FEBS journal.

Oestrogen receptor‐β1 but not oestrogen receptor‐βcx is of prognostic value in apocrine carcinoma of the breast

N. Harada, F. Akiyama, R. Horii, 2008, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Expression of oestrogen receptor-beta in apocrine carcinomas of the breast.

N. Harada, N. Yoshimura, F. Akiyama, 2007, Histopathology.

Localization of estrogen-synthase (aromatase) in the rat spinal cord

N. Harada, J. Balthazart, H. Evrard, 2001 .

Reciprocal expression of 17 a -hydroxylase-C17,20-lyase and aromatase cytochrome P450 during bovine trophoblast differentiation: a two-cell system drives placental oestrogen synthesis

N. Harada, B. Hoffmann, A. Conley, 2006 .

Transcriptional regulation of CYP19 by cohesin-mediated chromosome tethering in human granulosa cells

N. Harada, S. Ishihara, Y. Shimono, 2021, Biochemistry and biophysics reports.