E. Klann

发表

Extinction-Reconsolidation Boundaries: Key to Persistent Attenuation of Fear Memories

Joseph E LeDoux, M. Monfils, K. Cowansage, 2009, Science.

Mechanism of protein kinase C activation during the induction and maintenance of long-term potentiation probed using a selective peptide substrate.

S. J. Chen, J. Sweatt, E. Klann, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Hypothermia differentially increases extracellular signal-regulated kinase and stress-activated protein kinase/c-Jun terminal kinase activation in the hippocampus during reperfusion after asphyxial cardiac arrest

C. Callaway, E. Klann, D. DeFranco, 2000, Neuroscience.

Translational Control of Long-Lasting Synaptic Plasticity and Memory

N. Sonenberg, E. Klann, W. Sossin, 2009, Neuron.

Reactive oxygen species and synaptic plasticity in the aging hippocampus

Eric Klann, Faridis Serrano, E. Klann, 2004, Ageing Research Reviews.

A Role for Superoxide in Protein Kinase C Activation and Induction of Long-term Potentiation*

J. Sweatt, E. Klann, E. Roberson, 1998, The Journal of Biological Chemistry.

Making synaptic plasticity and memory last: mechanisms of translational regulation.

E. Klann, J. Richter, 2009, Genes & development.

Mitochondrial Superoxide Contributes to Blood Flow and Axonal Transport Deficits in the Tg2576 Mouse Model of Alzheimer's Disease

Robia G. Pautler, Eric Klann, Cynthia A. Massaad, 2010, PloS one.

Dynamic Translational and Proteasomal Regulation of Fragile X Mental Retardation Protein Controls mGluR-Dependent Long-Term Depression

Richard Paylor, Eric Klann, E. Klann, 2006, Neuron.

Translating from cancer to the brain: regulation of protein synthesis by eIF4F

E. Klann, Ilona R Kats, Ilona Kats, 2019, Learning & memory.

Early changes in the apparent diffusion coefficient (ADC) in a mouse model of Sandhoff's disease occur prior to disease symptoms and behavioral deficits

E. Klann, R. Pautler, R. Paylor, 2009, Magnetic resonance in medicine.

Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ΔRG mouse model of tuberous sclerosis complex

E. Klann, H. Kaphzan, J. Arbiser, 2012, Neurobiology of Disease.

The mouse as a model for neuropsychiatric drug development

Alcino J. Silva, M. Bear, S. Lipton, 2018, Current Biology.

A procedure for purifying low-abundance protein components from the brain cytoskeleton-nuclear matrix fraction

E. Klann, K. Shelton, Gerry Nixon, 1991, Journal of Neuroscience Methods.

Localization of extracellular superoxide dismutase in adult mouse brain

E. Klann, J. P. Card, T. Oury, 1999, Brain Research.

NADPH oxidase is required for NMDA receptor‐dependent activation of ERK in hippocampal area CA1

E. Klann, S. Holland, K. Kishida, 2005, Journal of neurochemistry.

Activation of the extracellular signal‐regulated kinase pathway contributes to the behavioral deficit of fragile x‐syndrome

Xinglong Wang, Xiongwei Zhu, G. Casadesus, 2012, Journal of neurochemistry.

The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory

E. Klann, Pumin Zhang, Zhubo Wei, 2008, Nature Cell Biology.

Chemogenetic evidence that rapid neuronal de novo protein synthesis is required for consolidation of long-term memory

Joseph E LeDoux, N. Heintz, E. Klann, 2019, bioRxiv.

Genetic removal of p70 S6K1 corrects coding sequence length-dependent alterations in mRNA translation in fragile X syndrome mice

E. Klann, Francesco Longo, Sameer Aryal, 2020, Proceedings of the National Academy of Sciences.

Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model

E. Klann, H. Erdjument-Bromage, T. Neubert, 2020, Communications biology.

Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.

M. B. Lourenço, E. Klann, T. E. Dever, 2019, Molecular cell.

Astrocytes derived from ASD individuals alter behavior and destabilize neuronal activity through aberrant Ca2+ signaling

C. Liston, E. Klann, Ben S. Huang, 2022, Molecular Psychiatry.

Deletion of Fmr1 in parvalbumin-expressing neurons results in dysregulated translation and selective behavioral deficits associated with fragile X syndrome

E. Klann, M. Kalinowska, Francesco Longo, 2022, Molecular Autism.

Shaping Dendritic Spines in Autism Spectrum Disorder: mTORC1-Dependent Macroautophagy

E. Klann, H. Bowling, 2014, Neuron.

Analysis of microglial BDNF function and expression in the motor cortex

E. Klann, L. Weinhard, Diana Honey, 2022, bioRxiv.

Altered steady state and activity-dependent de novo protein expression in fragile X syndrome

E. Klann, K. Kirshenbaum, E. Berry-Kravis, 2019, Nature Communications.

Cc2d1a Loss of Function Disrupts Functional and Morphological Development in Forebrain Neurons Leading to Cognitive and Social Deficits

Guangying K. Wu, C. Walsh, E. Klann, 2017, Cerebral cortex.

NADPH oxidase immunoreactivity in the mouse brain

E. Klann, J. P. Card, F. Serrano, 2003, Brain Research.

Mitochondrial superoxide: a key player in Alzheimer's disease

E. Klann, R. Pautler, C. A. Massaad, 2009, Aging.

Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model

E. Klann, R. Rivero, C. Gross, 2018, Neuropsychopharmacology.

NADPH oxidase mediates β-amyloid peptide-induced activation of ERK in hippocampal organotypic cultures

J. Sweatt, E. Klann, R. Pautler, 2009, Molecular Brain.

Accumulation of Polyribosomes in Dendritic Spine Heads, But Not Bases and Necks, during Memory Consolidation Depends on Cap-Dependent Translation Initiation

Joseph E LeDoux, Linnaea E. Ostroff, K. Cowansage, 2017, The Journal of Neuroscience.

Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease.

E. Klann, C. Keene, Brenna C. Beckelman, 2016, Journal of Alzheimer's disease : JAD.

Persistent Pain Is Dependent on Spinal Mitochondrial Antioxidant Levels

E. Klann, E. Schwartz, H. Kim, 2009, The Journal of Neuroscience.

Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the Delta RG mouse model of tuberous sclerosis complex

E. Klann, H. Kaphzan, J. Arbiser, 2022 .

Turning up translation in fragile X syndrome

E. Klann, Sameer Aryal, 2018, Science.

Synaptic plasticity and translation initiation.

Eric Klann, E. Klann, J. Banko, 2004, Learning & memory.

Identification of Fragile X Syndrome Specific Molecular Markers in Human Fibroblasts: A Useful Model to Test the Efficacy of Therapeutic Drugs

E. Klann, C. B. Smith, Kristen Moulton, 2014, Human mutation.

Members of the fragile X gene family exhibit genetic and phenotypic interaction in mammals

D. Nelson, E. Klann, J. Botas, 2006, International Journal of Developmental Neuroscience.

Optical Control of Translation with a Puromycin-Photoswitch

E. Klann, D. Trauner, Johannes Morstein, 2022, bioRxiv.

Thwarting Dyskinesia by Targeting mTORC1

E. Klann, 2009, Science Signaling.

Mitochondrial Superoxide Contributes to Hippocampal Synaptic Dysfunction and Memory Deficits in Angelman Syndrome Model Mice

E. Klann, H. Kaphzan, M. Murphy, 2015, The Journal of Neuroscience.

How ketamine helps to overcome depression

E. Klann, Thu N Huynh, 2014, eLife.

(Li+)ghting the Way for a Treatment for Cognitive Impairments in Fragile X Syndrome

E. Klann, A. Bhattacharya, 2014, Biological Psychiatry.

PERK: a novel therapeutic target for neurodegenerative diseases?

E. Klann, T. Ma, 2014, Alzheimer's Research & Therapy.

The Translation Repressor 4E-BP2 Is Critical for eIF4F Complex Formation, Synaptic Plasticity, and Memory in the Hippocampus

N. Sonenberg, E. Klann, C. Demaria, 2005, The Journal of Neuroscience.

Dysregulation of mTOR Signaling in Fragile X Syndrome

E. Klann, R. Zukin, S. McBride, 2010, The Journal of Neuroscience.

The modulation of emotional and social behaviors by oxytocin signaling in limbic network

E. Klann, Prerana Shrestha, J. LeDoux, 2022, Frontiers in Molecular Neuroscience.

Cell type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behaviour in fragile X syndrome model mice

E. Klann, N. Tritsch, C. Bagni, 2022, bioRxiv.

Superoxide dismutase and hippocampal function: age and isozyme matter.

E. Klann, E. Thiels, Daoying Hu, 2006, Antioxidants & redox signaling.

Enhanced phosphorylation of the postsynaptic protein kinase C substrate RC3/neurogranin during long-term potentiation

J. Sweatt, E. Klann, Shu-Jen Chen, 1997, Brain Research.

Amygdala Kindling Alters Protein Kinase C Activity in Dentate Gyrus

J. Sweatt, E. Klann, D. Winder, 1992, Journal of neurochemistry.

Increased Phosphorylation of a 17‐kDa Protein Kinase C Substrate (P17) in Long‐Term Potentiation

S. J. Chen, J. Sweatt, E. Klann, 1992, Journal of neurochemistry.

Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin

E. Klann, Itzamarie Chévere-Torres, Jordan M. Maki, 2012, Neurobiology of Disease.

Activation of a novel p70 S6 kinase 1-dependent intracellular cascade in the basolateral nucleus of the amygdala is required for the acquisition of extinction memory

Joseph E LeDoux, K. Deisseroth, L. Grosenick, 2017, Molecular Psychiatry.

mTOR signaling: At the crossroads of plasticity, memory and disease

E. Klann, C. Hoeffer, 2010, Trends in Neurosciences.

Persistent Activation of ERK Contributes to Glutamate-induced Oxidative Toxicity in a Neuronal Cell Line and Primary Cortical Neuron Cultures*

Jon W. Johnson, E. Klann, D. DeFranco, 2000, The Journal of Biological Chemistry.

Biochemical mechanisms for translational regulation in synaptic plasticity

E. Klann, T. Dever, 2004, Nature Reviews Neuroscience.

Modulation of protein kinases and protein phosphatases by reactive oxygen species: Implications for hippocampal synaptic plasticity

E. Klann, E. Thiels, 1999, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Protected‐Site Phosphorylation of Protein Kinase C in Hippocampal Long‐Term Potentiation

J. Sweatt, A. Newton, E. Klann, 1998, Journal of neurochemistry.

Increased Phosphorylation of Myelin Basic Protein During Hippocampal Long‐Term Potentiation

J. Sweatt, E. Klann, C. Atkins, 1997, Journal of neurochemistry.

Reactive oxygen species in the regulation of synaptic plasticity and memory.

E. Klann, C. A. Massaad, 2011, Antioxidants & redox signaling.

Reactive Oxygen Species, Synaptic Plasticity, and Memory

E. Klann, K. Kishida, 2009 .

Sources and targets of reactive oxygen species in synaptic plasticity and memory.

E. Klann, K. Kishida, 2006, Antioxidants & redox signaling.

Metaplastic protein phosphatases.

E. Klann, 2002, Learning & memory.

Potentiation of Hippocampal Synaptic Transmission by Superoxide Requires the Oxidative Activation of Protein Kinase C

E. Klann, L. Knapp, 2002, The Journal of Neuroscience.

The Extracellular Signal-Regulated Kinase Cascade Is Required for NMDA Receptor-Independent LTP in Area CA1 But Not Area CA3 of the Hippocampus

G. Barrionuevo, N. Urban, E. Klann, 2000, The Journal of Neuroscience.

Rapid isolation of synaptoneurosomes and postsynaptic densities from adult mouse hippocampus

E. Klann, L. Villasana, M. Tejada-Simon, 2006, Journal of Neuroscience Methods.

Role of reactive oxygen species in hippocampal long‐term potentiation: Contributory or inhibitory?

E. Klann, L. Knapp, 2002, Journal of neuroscience research.

Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease

Eric Klann, E. Klann, R. Pautler, 2009, Proceedings of the National Academy of Sciences.

Stimulation of p42 and p44 Mitogen‐Activated Protein Kinases by Reactive Oxygen Species and Nitric Oxide in Hippocampus

E. Klann, L. Knapp, B. Kanterewicz, 1998, Journal of neurochemistry.

Transient and persistent increases in protein phosphatase activity during long-term depression in the adult hippocampus in vivo

E Thiels, G. Barrionuevo, E. Klann, 1998, Neuroscience.

Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus.

Eric Klann, Jennifer N Gelinas, E. Weeber, 2008, Learning & memory.

Synaptic Plasticity Deficits and Mild Memory Impairments in Mouse Models of Chronic Granulomatous Disease

E. Klann, S. Holland, K. Kishida, 2006, Molecular and Cellular Biology.

Glutamate-induced neuron death requires mitochondrial calcium uptake

Ian J. Reynolds, Eric Klann, E. Klann, 1998, Nature Neuroscience.

RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer’s disease

E. Klann, B. Rothermel, P. Cain, 2015, Acta Neuropathologica.

Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons.

E. Klann, C. Hidalgo, M. Müller, 2007, Cell calcium.

Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome

E. Klann, T. K. Best, A. Balbo, 2006, Journal of neurochemistry.

Synaptic localization of a functional NADPH oxidase in the mouse hippocampus

Gang-yi Wu, E. Klann, F. Serrano, 2005, Molecular and Cellular Neuroscience.

The molecular basis of cognitive deficits in pervasive developmental disorders.

E. Klann, A. Bhattacharya, 2012, Learning & memory.

UPF2 leads to degradation of dendritically targeted mRNAs to regulate synaptic plasticity and cognitive function

E. Klann, M. Toth, D. Çolak, 2019, Molecular Psychiatry.

The Nonsense-Mediated mRNA Decay pathway degrades dendritically-targeted mRNAs to regulate long-term potentiation and cognitive function

E. Klann, M. Toth, N. Jeon, 2018 .

Compartmentalized nonsense-mediated mRNA decay regulates synaptic plasticity and cognitive function via GluR1 signaling

E. Klann, M. Toth, D. Çolak, 2018, bioRxiv.

Cell-permeable scavengers of superoxide prevent long-term potentiation in hippocampal area CA1.

E. Klann, Eric Klann, Eric Klann, 1998, Journal of neurophysiology.

mGluR-Dependent Long-Term Depression Is Associated with Increased Phosphorylation of S6 and Synthesis of Elongation Factor 1A but Remains Expressed in S6K-Deficient Mice

E. Klann, L. Hou, M. Antion, 2008, Molecular and Cellular Biology.

Reciprocal control of translation and transcription in autism spectrum disorder

E. Klann, Francesco Longo, 2021, EMBO reports.

Exaggerated Translation Causes Synaptic and Behavioral Aberrations Associated with Autism

E. Klann, H. Kaphzan, D. Ruggero, 2012, Nature.

Activation of the Phosphoinositide 3-Kinase-Akt-Mammalian Target of Rapamycin Signaling Pathway Is Required for Metabotropic Glutamate Receptor-Dependent Long-Term Depression

Eric Klann, E. Klann, L. Hou, 2004, The Journal of Neuroscience.

CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation

Linnaea E. Ostroff, S. Grant, D. Posthuma, 2013, Neuron.

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

E. Klann, R. Blitzer, T. Ma, 2010, PloS one.

Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase

Gang-yi Wu, E. Klann, T. Oury, 2007, Neurobiology of Learning and Memory.

Regulation of Eukaryotic Initiation Factor 4E by Converging Signaling Pathways during Metabotropic Glutamate Receptor-Dependent Long-Term Depression

N. Sonenberg, E. Klann, J. Banko, 2006, The Journal of Neuroscience.

Local RNA Translation at the Synapse and in Disease

S. Warren, E. Klann, A. Gitler, 2011, The Journal of Neuroscience.

Targeting Translation Control with p70 S6 Kinase 1 Inhibitors to Reverse Phenotypes in Fragile X Syndrome Mice

E. Klann, A. Bhattacharya, Daniel G Smith, 2016, Neuropsychopharmacology.

Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

E. Klann, H. Kaphzan, P. Pierre, 2012, Neuron.

Regulator of Calcineurin 1 Modulates Expression of Innate Anxiety and Anxiogenic Responses to Selective Serotonin Reuptake Inhibitor Treatment

K. Cowansage, E. Klann, D. McMillan, 2013, The Journal of Neuroscience.

N-terminal variant Asp14Asn of the human p70 S6 Kinase 1 enhances translational signaling causing different effects in developing and mature neuronal cells

S. Chattarji, E. Klann, I. Iossifov, 2020, Neurobiology of Learning and Memory.

Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis

Chadwick M. Hales, P. Jin, S. Warren, 2021, Cell reports.

Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome.

Seth M. Kelly, J. Gibson, T. Jongens, 2015, Cell reports.

Genetic and Acute CPEB Depletion Ameliorate Fragile X Pathophysiology

S. Chattarji, E. Klann, S. Akbarian, 2013, Nature Medicine.

The translation of translational control by FMRP: therapeutic targets for FXS

J. Darnell, E. Klann, 2013, Nature Neuroscience.

Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome

E. Klann, R. Zukin, F. Tassone, 2012, Genes, brain, and behavior.

Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome

S. Chattarji, E. Klann, Aparna Suvrathan, 2010, Proceedings of the National Academy of Sciences.

Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference.

Alcino J. Silva, E. Klann, D. Kwiatkowski, 2016, Pediatric neurology.

Astrocytes derived from ASD patients alter behavior and destabilize neuronal activity through aberrant Ca2+ signaling

C. Liston, E. Klann, Ben S. Huang, 2021, bioRxiv.

Suppression of eIF2 a kinases alleviates Alzheimer’s disease–related plasticity and memory deficits

E. Klann, D. Cavener, P. Pierre, 2013 .

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

E. Klann, H. Kaphzan, E. Chen, 2012, Molecular Neurodegeneration.

Translational control of synaptic plasticity and learning and memory

E. Klann, J. Richter, 2007 .

PA GE P RO OF 18 Translational Control of Synaptic Plasticity and Learning and Memory

E. Klann, 2006 .

Peroxynitrite-induced tyrosine nitration and inhibition of protein kinase C.

E. Klann, L. Knapp, B. Kanterewicz, 2001, Biochemical and biophysical research communications.

Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer’s disease

E. Klann, T. Ma, 2012, Journal of neurochemistry.

Inhibition of AMP-Activated Protein Kinase Signaling Alleviates Impairments in Hippocampal Synaptic Plasticity Induced by Amyloid β

B. Viollet, E. Klann, T. Ma, 2014, The Journal of Neuroscience.

Suppression of eIF2α kinases alleviates AD-related synaptic plasticity and spatial memory deficits

E. Klann, T. Ma, D. Cavener, 2013, Nature Neuroscience.

Studies with synthetic peptide substrates derived from the neuronal protein neurogranin reveal structural determinants of potency and selectivity for protein kinase C.

S. J. Chen, J. Sweatt, E. Klann, 1993, Biochemistry.

The Down Syndrome Critical Region Protein RCAN1 Regulates Long-Term Potentiation and Memory via Inhibition of Phosphatase Signaling

E. Klann, J. Richardson, J. Shelton, 2007, The Journal of Neuroscience.

potentiationent hippocampal long-term Multiple components of eIF4F are required for protein

R. E. Luna, E. Papadopoulos, J. Lacaille, 2015 .

Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation.

E. Klann, J. Pelletier, T. Ma, 2013, Journal of neurophysiology.

Effects of GDNF on 6‐OHDA‐induced death in a dopaminergic cell line: Modulation by inhibitors of PI3 kinase and MEK

M. Zigmond, E. Klann, Eva Lin, 2003, Journal of neuroscience research.

Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amygdala

Robert M Sears, Joseph E LeDoux, Linnaea E. Ostroff, 2019, eLife.

The translatome of adult cortical axons is regulated by learning in vivo

Robert M Sears, Joseph E LeDoux, Linnaea E. Ostroff, 2018 .

Reciprocal signaling between translational control pathways and synaptic proteins in autism spectrum disorders

E. Klann, E. Santini, 2014, Science Signaling.

Mechanisms of translation control underlying long-lasting synaptic plasticity and the consolidation of long-term memory.

E. Klann, E. Santini, Thu N Huynh, 2014, Progress in molecular biology and translational science.

Cell type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation

Joseph E LeDoux, N. Heintz, E. Klann, 2019, Nature Neuroscience.

References and Notes

Jonathan Grainger, Joël Fagot, Stéphane Dufau, 2022 .

Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.

E. Klann, H. Kaphzan, R. Wek, 2012, Cell reports.

Translational Regulation of Synaptic Plasticity

E. Klann, E. Santini, C. Hoeffer, 2013 .

In-Depth Quantitative Proteomic Analysis of de Novo Protein Synthesis Induced by Brain-Derived Neurotrophic Factor

Guoan Zhang, Eric Klann, Kent Kirshenbaum, 2014, Journal of proteome research.

Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer’s disease

E. Klann, Wenzhong Yang, Nicole P. Kasica, 2021, Science Signaling.

Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer’s disease

E. Klann, Wenzhong Yang, Nicole P. Kasica, 2020, Science Signaling.

Deconstructing brain-derived neurotrophic factor actions in adult brain circuits to bridge an existing informational gap in neuro-cell biology

E. Klann, M. Chao, H. Bowling, 2016, Neural regeneration research.

Aging-Dependent Alterations in Synaptic Plasticity and Memory in Mice That Overexpress Extracellular Superoxide Dismutase

E. Klann, T. Oury, F. Serrano, 2006, The Journal of Neuroscience.

Reversal of Impaired Hippocampal Long-Term Potentiation and Contextual Fear Memory Deficits in Angelman Syndrome Model Mice by ErbB Inhibitors

T. Abel, P. Hernandez, K. Cowansage, 2012, Biological Psychiatry.

NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea.

E. Klann, D. Praticò, F. Serrano, 2005, American journal of respiratory and critical care medicine.

Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity.

E. Klann, M. Merhav, K. Rosenblum, 2008, Learning & memory.

Nitric oxide synthase-independent long-term potentiation in area CA1 of hippocampus.

J. Sweatt, E. Klann, D. Chetkovich, 1993, Neuroreport.

Genetic reduction of the α1 subunit of Na/K-ATPase corrects multiple hippocampal phenotypes in Angelman syndrome.

E. Klann, H. Kaphzan, J. Lingrel, 2013, Cell reports.

A nuclear matrix protein stabilized by lead exposure: current knowledge and future prospects.

E. Klann, J. Bigbee, K. Shelton, 1993, Neurotoxicology.

Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease

E. Klann, Wenzhong Yang, Xueyan Zhou, 2016, Neurobiology of Aging.

Amyloid β-Induced Impairments in Hippocampal Synaptic Plasticity Are Rescued by Decreasing Mitochondrial Superoxide

C. Iadecola, E. Klann, R. Pautler, 2011, The Journal of Neuroscience.

Impairment of Long-term Potentiation and Associative Memory in Mice That Overexpress Extracellular Superoxide Dismutase

G. Barrionuevo, N. Urban, E. Klann, 2000, The Journal of Neuroscience.

Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model

E. Klann, H. Erdjument-Bromage, T. Neubert, 2021, Communications Biology.

Removal of FKBP12 Enhances mTOR-Raptor Interactions, LTP, Memory, and Perseverative/Repetitive Behavior

E. Klann, R. Paylor, S. Hamilton, 2008, Neuron.

Altered steady state and activity-dependent de novo protein expression in fragile X syndrome

E. Klann, K. Kirshenbaum, E. Berry-Kravis, 2019, Nature Communications.

BONLAC: A combinatorial proteomic technique to measure stimulus-induced translational profiles in brain slices

C. Vogel, E. Klann, K. Kirshenbaum, 2016, Neuropharmacology.

Antipsychotics Activate mTORC1-Dependent Translation to Enhance Neuronal Morphological Complexity

W. Gan, E. Klann, L. M. Pérez-Cuesta, 2014, Science Signaling.

Basal variability in CREB phosphorylation predicts trait-like differences in amygdala-dependent memory

Joseph E LeDoux, D. Bush, S. Josselyn, 2013, Proceedings of the National Academy of Sciences.

PERK: a novel therapeutic target for neurodegenerative diseases?

E. Klann, T. Ma, 2014, Alzheimer's Research & Therapy.

Dysregulation and restoration of translational homeostasis in fragile X syndrome

E. Klann, J. Richter, G. Bassell, 2015, Nature Reviews Neuroscience.

A Nitric Oxide/Cyclic GMP‐Dependent Protein Kinase Pathway Alters Transmitter Release and Inhibition by Somatostatin at a Site Downstream of Calcium Entry

E. Klann, R. Metzger, L. Polo-Parada, 1999, Journal of neurochemistry.

Dysregulation of the de novo proteome accompanies pathology progression in the APP/PS1 mouse model of Alzheimer’s disease

E. Klann, H. Erdjument-Bromage, T. Neubert, 2020, bioRxiv.

Inositol polyphosphate multikinase mediates extinction of fear memory

S. Snyder, E. Klann, Jin-Hee Han, 2019, Proceedings of the National Academy of Sciences.

Effects of acute sleep deprivation on motor and reversal learning in mice

E. Klann, A. Varga, Mihwa Kang, 2014, Neurobiology of Learning and Memory.

Altered protein synthesis is a trigger for long-term memory formation

Eric Klann, J. David Sweatt, J. Sweatt, 2008, Neurobiology of Learning and Memory.

ERK and mTOR Signaling Couple β-Adrenergic Receptors to Translation Initiation Machinery to Gate Induction of Protein Synthesis-dependent Long-term Potentiation*

Eric Klann, Nahum Sonenberg, Jennifer N Gelinas, 2007, Journal of Biological Chemistry.

Early Maintenance of Hippocampal Mossy Fiber—Long-Term Potentiation Depends on Protein and RNA Synthesis and Presynaptic Granule Cell Integrity

G. Barrionuevo, E. Klann, E. Thiels, 2003, The Journal of Neuroscience.

Long-Term Depression in the Adult Hippocampus In Vivo Involves Activation of Extracellular Signal-Regulated Kinase and Phosphorylation of Elk-1

E. Klann, J. Trzăskos, E. Thiels, 2002, The Journal of Neuroscience.

Oxidation-induced persistent activation of protein kinase C in hippocampal homogenates.

S. J. Chen, J. Sweatt, E. Klann, 1992, Biochemical and biophysical research communications.

Superoxide-induced Stimulation of Protein Kinase C via Thiol Modification and Modulation of Zinc Content*

E. Klann, L. Knapp, 2000, The Journal of Biological Chemistry.

Cap-dependent translation initiation and memory.

E. Klann, J. Banko, 2008, Progress in brain research.

NMDA receptor activation results in PKA‐ and ERK‐dependent Mnk1 activation and increased eIF4E phosphorylation in hippocampal area CA1

E. Klann, J. Banko, L. Hou, 2004, Journal of neurochemistry.

Long‐Term Depression in the Hippocampus In Vivo Is Associated with Protein Phosphatase‐Dependent Alterations in Extracellular Signal‐Regulated Kinase

G. Barrionuevo, E. Klann, E. Thiels, 2000, Journal of neurochemistry.

Extracellular Signal-Regulated Kinase, Synaptic Plasticity, and Memory

E. Klann, E. Thiels, 2001, Reviews in the neurosciences.

Protein Phosphatase-Mediated Regulation of Protein Kinase C during Long-Term Depression in the Adult Hippocampus In Vivo

G. Barrionuevo, E. Klann, E. Thiels, 2000, The Journal of Neuroscience.

Behavioral alterations in mice lacking the translation repressor 4E-BP2

N. Sonenberg, E. Klann, M. Merhav, 2007, Neurobiology of Learning and Memory.

Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism

E. Klann, R. Zukin, M. Costa-Mattioli, 2015, The Journal of Neuroscience.

Amygdala inhibitory neurons as loci for translation in emotional memories

N. Heintz, E. Klann, J. Pelletier, 2020, Nature.

Amygdala inhibitory neurons as loci for translation in emotional memories

N. Heintz, E. Klann, J. Pelletier, 2020, Nature.

De novo protein synthesis in distinct centrolateral amygdala interneurons is required for associative emotional memories

N. Heintz, E. Klann, J. Pelletier, 2020, bioRxiv.

Spatiotemporally resolved protein synthesis as a molecular framework for memory consolidation

E. Klann, Prerana Shrestha, 2022, Trends in Neurosciences.

Alzheimer's disease: Lost memories found

E. Klann, Prerana Shrestha, 2016, Nature.

Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation

Joseph E LeDoux, K. Cowansage, E. Klann, 2011, Proceedings of the National Academy of Sciences.

Translocation and activation of Rac in the hippocampus during associative contextual fear learning

E. Klann, M. Tejada-Simon, L. Martínez, 2007, Neurobiology of Learning and Memory.

Upregulation of eIF4E, but not other translation initiation factors, in dendritic spines during memory formation

Linnaea E. Ostroff, K. Cowansage, E. Klann, 2021, The Journal of comparative neurology.

Upregulation of eIF4E, but not other translation initiation factors, in dendritic spines during memory consolidation

Joseph E LeDoux, Linnaea E. Ostroff, K. Cowansage, 2021, bioRxiv.

Tyrosine phosphatases: cellular functions and therapeutic potential

E. Klann, E. Norman, A. G. Klann, 2000 .

The E3 ligase APC/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult mice.

M. Malumbres, E. Klann, Joseph E. Pick, 2012, Learning & memory.

Persistent protein kinase activation in the maintenance phase of long-term potentiation.

S. J. Chen, J. Sweatt, E. Klann, 1991, The Journal of biological chemistry.

Regulation of Neuronal Gene Expression and Protein Synthesis

C. Alberini, E. Klann, 2014 .

Translational Control Mechanisms in Synaptic Plasticity and Memory

N. Sonenberg, E. Klann, M. Costa-Mattioli, 2008 .

Genetically Dissecting Cortical Neurons Involved in Epilepsy in Angelman Syndrome

Eric Klann, E. Klann, Emanuela Santini, 2016, Neuron.

Prohibitin Viral Gene Transfer Protects Hippocampal CA1 Neurons From Ischemia and Ameliorates Postischemic Hippocampal Dysfunction

C. Iadecola, E. Klann, T. Ma, 2014, Stroke.

Symposia Abstracts

Lisa Y. M. Chuah, P. K. Banerjee, J. Siegel, 2005 .

Altered striatal actin dynamics drives behavioral inflexibility in a mouse model of fragile X syndrome

S. Grant, E. Klann, G. Pedini, 2023, Neuron.

Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function

M. Rice, E. Klann, J. Patel, 2021, Molecular Psychiatry.

Genetic reduction of PERK-eIF2α signaling in dopaminergic neurons drives cognitive and age-dependent motor dysfunction

M. Rice, E. Klann, J. Patel, 2020, bioRxiv.

Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory

E. Klann, Mimi A. Trinh, 2013, Neurobiology of Learning and Memory.

Coordinate Regulation of Mature Dopaminergic Axon Morphology by Macroautophagy and the PTEN Signaling Pathway

E. Klann, M. Beal, A. Abeliovich, 2013, PLoS genetics.

The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression

E. Klann, H. Kaphzan, T. Ma, 2014, Learning & memory.

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

E. Klann, H. Kaphzan, E. Chen, 2012, Molecular Neurodegeneration.

A lead-associated nuclear protein which increases in maturing brain and in differentiating neuroblastoma 2A cells exposed to cyclic AMP-elevating agents.

E. Klann, K. Shelton, 1990, Brain research. Developmental brain research.

Low‐abundance 32‐kilodalton nuclear protein specifically enriched in the central nervous system

E. Klann, J. G. Cunningham, K. Shelton, 1990, Journal of neuroscience research.

The effect of lead on the metabolism of a nuclear matrix protein which becomes prominent in lead-induced intranuclear inclusion bodies.

E. Klann, K. Shelton, 1989, The Journal of biological chemistry.

Haloperidol Regulates the State of Phosphorylation of Ribosomal Protein S6 via Activation of PKA and Phosphorylation of DARPP-32

G. Fisone, J. Girault, E. Valjent, 2011, Neuropsychopharmacology.

Requirement of Mammalian Target of Rapamycin Complex 1 Downstream Effectors in Cued Fear Memory Reconsolidation and Its Persistence

E. Klann, E. Santini, Thu N Huynh, 2014, The Journal of Neuroscience.

Alterations in Intrinsic Membrane Properties and the Axon Initial Segment in a Mouse Model of Angelman Syndrome

Eric Klann, E. Klann, H. Kaphzan, 2011, The Journal of Neuroscience.

Fragile X mental retardation protein regulates heterosynaptic plasticity in the hippocampus.

Steven A. Connor, E. Klann, P. Nguyen, 2011, Learning & memory.

eIF2-dependent translation initiation: Memory consolidation and disruption in Alzheimer's disease.

E. Klann, Mauricio M. Oliveira, 2021, Seminars in cell & developmental biology.

Cell type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation

Joseph E LeDoux, N. Heintz, E. Klann, 2019, Nature Neuroscience.

NMDA Receptors and Translational Control

E. Klann, C. Hoeffer, 2009 .

Autism- and epilepsy-associated EEF1A2 mutations lead to translational dysfunction and altered actin bundling

E. Klann, Muhaned S. Mohamed, 2023, bioRxiv.

Blood-Based Biomarkers Predictive of Metformin Target Engagement in Fragile X Syndrome

E. Klann, F. Tassone, R. Hagerman, 2020, Brain sciences.

Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice

E. Klann, C. Bagni, S. Koo, 2017, Science Signaling.

Glucagon-Like Peptide-1 Cleavage Product GLP-1(9-36) Amide Rescues Synaptic Plasticity and Memory Deficits in Alzheimer's Disease Model Mice

E. Klann, T. Ma, M. Brownlee, 2012, The Journal of Neuroscience.

A deep dive into local mRNA translation in neurons

E. Klann, Mauricio M. Oliveira, 2021, Proceedings of the National Academy of Sciences.

Use of the synthetic peptide neurogranin(28-43) as a selective protein kinase C substrate in assays of tissue homogenates.

S. J. Chen, E. Klann, A. González, 1993, Analytical biochemistry.

Optimization of protocols for detection of de novo protein synthesis in whole blood samples via azide-alkyne cycloaddition.

E. Klann, K. Kirshenbaum, E. Berry-Kravis, 2020, Journal of proteome research.

Proteomic Tools to Study the Effect of BDNF on De Novo Protein Synthesis

E. Klann, H. Bowling, 2018 .

Neuronal Morphological Complexity Antipsychotics Activate mTORC 1-Dependent Translation to Enhance

W. Gan, E. Klann, L. M. Pérez-Cuesta, 2014 .

Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models.

Eric Klann, David L Nelson, D. Nelson, 2009, Journal of neurophysiology.

Gene Family Knockout Mouse Models Fmr1 Altered Hippocampal Synaptic Plasticity in the

D. Nelson, E. Klann, B. Martin, 2015 .

Fragile X Syndrome Therapeutics S(C)TEP through the Developmental Window

E. Klann, A. Bhattacharya, 2012, Neuron.

Dysregulated mTORC1-Dependent Translational Control: From Brain Disorders to Psychoactive Drugs

E. Klann, E. Santini, 2011, Front. Behav. Neurosci..

Hippocampal memory and plasticity in superoxide dismutase mutant mice

E. Klann, E. Thiels, 2002, Physiology & Behavior.

Overexpression of the autism candidate gene Cyfip1 pathologically enhances olivo-cerebellar signaling in mice

C. Hansel, E. Klann, C. Gomez, 2023, Frontiers in Cellular Neuroscience.

NMDA receptor activation induces translocation and activation of Rac in mouse hippocampal area CA1.

E. Klann, F. Serrano, L. Villasana, 2006, Biochemical and biophysical research communications.

Superoxide-induced potentiation in the hippocampus requires activation of ryanodine receptor type 3 and ERK.

E. Klann, H. Takeshima, S. Hamilton, 2008, Journal of neurophysiology.

ERK Requires Activation of Ryanodine Receptor Type 3 and Superoxide-Induced Potentiation in the Hippocampus

E. Klann, H. Takeshima, S. Hamilton, 2008 .

Excessive Cap-dependent Translation as a Molecular Mechanism Underlying ASD

E. Klann, 2013 .

Title Increased Expression of the PI 3 K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome

Seth M. Kelly, J. Gibson, T. Jongens, 2016 .

Increased Expression of the PI 3 K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome

Seth M. Kelly, J. Gibson, T. Jongens, 2016 .

The integrated stress response effector GADD34 is repurposed by neurons to promote stimulus-induced translation

E. Klann, Snehajyoti Chatterjee, T. Abel, 2023, bioRxiv.

Free Communication Abstracts

Y. Lai, J. Siegel, R. Bootzin, 2005 .

eIF4E/Fmr1 double mutant mice display cognitive impairment in addition to ASD-like behaviors

E. Klann, S. Koo, E. Santini, 2015, Neurobiology of Disease.

Development / Plasticity / Repair

J. Knierim, H. Scharfman, T. Ebner, 2012 .

Suppression of eIF 2 α kinases alleviates AD-related synaptic plasticity and spatial memory deficits

E. Klann, T. Ma, D. Cavener, 2016 .

Calmodulin activity regulates group I metabotropic glutamate receptor‐mediated signal transduction and synaptic depression

E. Klann, H. Kaphzan, Hongbing Wang, 2016, Journal of neuroscience research.

Erratum: Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome (Journal of Neurochemistry (2006) 98 (1266-1277))

E. Klann, T. K. Best, A. Balbo, 2006 .

Activation of the extracellular signal‐regulated kinase pathway contributes to the behavioral deficit of fragile x‐syndrome

Xiongwei Zhu, G. Casadesus, E. Klann, 2012, Journal of neurochemistry.

Molecular functions of the mammalian fragile X mental retardation protein: insights into mental retardation and synaptic plasticity

E. Klann, C. Bagni, 2011 .

Switching Gears: Translational Mastery of Transcription during Memory Formation

E. Klann, C. Hoeffer, 2007, Neuron.

Interactions Between Sleep Disruption, Motor Learning, and p70 S6 Kinase 1 Signaling.

E. Klann, K. Kam, A. Varga, 2019, Sleep.

Cell-type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behavior in fragile X syndrome model mice

E. Klann, C. Bagni, Nicolas X. Tritsch, 2023, Cell reports.