D. Levy

D. Levy, M. Hirata, J. Enterline, 1996, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

IRF3 and IRF7 Phosphorylation in Virus-infected Cells Does Not Require Double-stranded RNA-dependent Protein Kinase R or IκB Kinase but Is Blocked by Vaccinia Virus E3L Protein*

D. Levy, A. García-Sastre, Eric J. Smith, 2001, The Journal of Biological Chemistry.

IL-21 Mediates Suppressive Effects via Its Induction of IL-101

D. Levy, W. Leonard, Hyoung-Pyo Kim, 2009, The Journal of Immunology.

HDAC stimulates gene expression through BRD4 availability in response to IFN and in interferonopathies

D. Levy, I. Marié, Hao‐Ming Chang, 2018, The Journal of experimental medicine.

TLR4 engagement during TLR3-induced proinflammatory signaling in dendritic cells promotes IL-10-mediated suppression of antitumor immunity.

D. Levy, N. Bhardwaj, A. Salazar, 2011, Cancer research.

Type I IFN Receptor-Signaling Complex Functions as a Scaffold Protein Within the The WD Motif-Containing Protein RACK-1

D. Levy, A. Usacheva, O. Colamonici, 2003 .

Th 17 Polarization c-Maf Regulates IL-10 Expression during Bromberg and Yaozhong

Zhihong Wu, D. Levy, G. Qiu, 2009 .

Interferon-γ-induced inhibition of neuronal vesicular stomatitis virus infection is STAT1 dependent

D. Chesler, D. Levy, C. Reiss, 2004, Journal of NeuroVirology.

The house that Jak/Stat built.

D. Levy, 1997, Cytokine & growth factor reviews.

Listeria monocytogenes Macrophages to Cell Death Induced by Production of Type I IFN Sensitizes

D. Levy, T. Decker, T. Chakraborty, 2002 .

Correction: The MEK-ERK Pathway Is Necessary for Serine Phosphorylation of Mitochondrial STAT3 and Ras-Mediated Transformation

D. Levy, D. Gough, Lisa Koetz, 2013, PLoS ONE.

Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family.

J. Coligan, K. Sakaguchi, E. Appella, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region.

J. Darnell, D. Levy, L. Babiss, 1986, Proceedings of the National Academy of Sciences of the United States of America.

STAT 3 positively regulates an early step in B-cell development

D. Levy, W. Chou, Chien-Kuo Lee, 2006 .

STAT 3 positively regulates an early step in B-cell development

D. Levy, W. Chou, Chien-Kuo Lee, 2006 .

Regulation of IRF7 through cell type-specific protein stability.

D. Levy, A. Prakash, 2006, Biochemical and biophysical research communications.

IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca2+ through the noncanonical STAT3 pathway

D. Levy, Haitao Wen, D. Frank, 2021, Proceedings of the National Academy of Sciences.

The interferon-stimulable response elements of two human genes detect overlapping sets of transcription factors.

D. Levy, G. Stark, I. Kerr, 1993, European journal of biochemistry.

Transcriptional stimulation by CaPO4-DNA precipitates.

J. Darnell, D. Levy, N. Reich, 1988, Nucleic acids research.

Interactions of alpha‐ and gamma‐interferon in the transcriptional regulation of the gene encoding a guanylate‐binding protein.

J. Darnell, D. Levy, T. Decker, 1989, The EMBO journal.

Deletion of Stat3 blocks mammary gland involution and extends functional competence of the secretory epithelium in the absence of lactogenic stimuli.

D. Levy, L. Hennighausen, Brian Bierie, 2002, Endocrinology.

STATus report on tetramers.

D. Levy, I. Marié, I. Marié, 2012, Immunity.

Chemokine Gene Silencing in Decidual Stromal Cells Limits T Cell Access to the Maternal-Fetal Interface

D. Levy, P. Asp, Patrice Nancy, 2012, Science.

Identification of a Stat3-dependent transcription regulatory network involved in metastatic progression.

D. Levy, M. Hallett, W. Muller, 2009, Cancer research.

IFN-Mediated Antiviral Response STAT3 Negatively Regulates Type I

D. Levy, Chien-Kuo Lee, 2011 .

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

D. Levy, J. Węgrzyn, D. Gough, 2009, Science.

Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors.

D. Levy, J. Durbin, R. Raz, 1994, The Journal of biological chemistry.

Synergistic interaction between interferon‐alpha and interferon‐gamma through induced synthesis of one subunit of the transcription factor ISGF3.

J. Darnell, D. Levy, D. Kessler, 1990, The EMBO journal.

Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems.

D. Levy, A. García-Sastre, T. Muster, 1998, Virology.

IFNgamma signaling-does it mean JAK-STAT?

David E Levy, Ricky W Johnstone, D. Levy, 2008, Cytokine & growth factor reviews.

Mitochondrial STAT3 regulates antioxidant gene expression through complex I‐derived NAD in triple negative breast cancer

B. Ueberheide, D. Levy, M. Askenazi, 2021, Molecular oncology.

IL-6 signaling via the STAT3/SOCS3 pathway: Functional Analysis of the Conserved STAT3 N-domain

D. Levy, Jack Bevers, P. Murray, 2006, Molecular and Cellular Biochemistry.

Induction and function of type I and III interferon in response to viral infection.

D. Levy, J. Durbin, I. Marié, 2011, Current opinion in virology.

A genetic locus regulates the expression of tissue-specific mRNAs from multiple transcription units.

R. Lerner, D. Levy, M. Wilson, 1982, Proceedings of the National Academy of Sciences of the United States of America.

What does Stat3 do?

D. Levy, Chien-Kuo Lee, 2002, The Journal of clinical investigation.

Constitutive type I interferon modulates homeostatic balance through tonic signaling.

D. Levy, R. Johnstone, N. Messina, 2012, Immunity.

Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice

D. Levy, D. Gilliland, 2000, Oncogene.

Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro.

J. Darnell, D. Levy, D. Kessler, 1989, Genes & development.

STAT3 Negatively Regulates Type I IFN-Mediated Antiviral Response

D. Levy, Chien-Kuo Lee, Wei-Bei Wang, 2011, The Journal of Immunology.

The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion.

D. Levy, A. García-Sastre, D. Levy, 2001, Cytokine & growth factor reviews.

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway.

David E Levy, Genevieve Konopka, Azad Bonni, 2008, Genes & development.

Proto-oncogene PML controls genes devoted to MHC class I antigen presentation

D. Levy, Yang Liu, Yong Guo, 1998, Nature.

Differential Regulation of Constitutive Major Histocompatibility Complex Class I Expression in T and B Lymphocytes

D. Levy, R. Gimeno, Chien-Kuo Lee, 1999, The Journal of experimental medicine.

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

D. Levy, M. Simon, J. Durbin, 1996, Cell.

PKR Transduces MDA5-Dependent Signals for Type I IFN Induction

D. Levy, Alissa M. Pham, F. Santa Maria, 2016, PLoS pathogens.

Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity.

David E Levy, C. Rice, D. Levy, 2004, Proceedings of the National Academy of Sciences of the United States of America.

A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation

D. Levy, S. King, F. Zhu, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Differential viral induction of distinct interferon‐α genes by positive feedback through interferon regulatory factor‐7

D. Levy, J. Durbin, I. Marié, 1998, The EMBO journal.

Inhibition of Nonsense-Mediated RNA Decay by the Tumor Microenvironment Promotes Tumorigenesis

J. Zavadil, D. Levy, F. Parisi, 2011, Molecular and Cellular Biology.

Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

D. Levy, T. Leanderson, C. Bogdan, 2003, Nature Immunology.

STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas

R. Cardiff, D. Levy, M. Welch, 2012, Breast Cancer Research.

STAT1 Affects Lymphocyte Survival and Proliferation Partially Independent of Its Role Downstream of IFN-γ1

David E. Levy, D. Levy, R. Gimeno, 2000, The Journal of Immunology.

Role Downstream of IFN-Proliferation Partially Independent of Its STAT 1 Affects Lymphocyte Survival and and

D. Levy, R. Gimeno, Eric J. Smith, 2000 .

Essential role of STAT3 for embryonic stem cell pluripotency.

P. D’Eustachio, D. Levy, R. Raz, 1999, Proceedings of the National Academy of Sciences of the United States of America.

The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4+ T Cells via a Novel CDK8-GATA3-FOXP3 Pathway

Kaitlin J. Flynn, R. Xavier, P. Linsley, 2021, Molecular and cellular biology.

The CDK8 inhibitor DCA promotes a tolerogenic chemical immunophenotype in CD4+ T cells via a novel CDK8-GATA3-FOXP3 pathway

Kaitlin J. Flynn, R. Xavier, P. Linsley, 2019, bioRxiv.

The CDK8 inhibitor DCA promotes a tolerogenic chemical immunophenotype in CD4+ T cells via a novel CDK8-GATA3-FOXP3 pathway

Kaitlin J. Flynn, R. Xavier, P. Linsley, 2019, bioRxiv.

Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.

J. Darnell, D. Levy, N. Reich, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target

D. Levy, G. Inghirami, J. Karras, 2005, Nature Medicine.

Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3.

D. Levy, K. Schlessinger, 2005, Cancer research.

STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation.

R. DePinho, K. Takeshita, D. Levy, 2002, Immunity.

The MEK-ERK Pathway Is Necessary for Serine Phosphorylation of Mitochondrial STAT3 and Ras-Mediated Transformation

D. Levy, D. Gough, Lisa Koetz, 2013, PloS one.

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2.

M. Loh, J. Aster, D. Levy, 2000, Molecular cell.

Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins

R. Aebersold, J. Darnell, D. Levy, 1992, Molecular and cellular biology.

The molecular basis of IL-21-mediated proliferation.

D. Levy, W. Leonard, R. Spolski, 2007, Blood.

Reduction of Stat3 activity attenuates HIV-induced kidney injury.

R. Iyengar, D. Levy, V. D’Agati, 2009, Journal of the American Society of Nephrology : JASN.

Genetic elements used for a murine lupus anti-DNA autoantibody are closely related to those for antibodies to exogenous antigens

D. Levy, R. Kofler, D. Noonan, 1985, The Journal of experimental medicine.

176 IL-6 Programs TH-17 Cell Differentiation by Promoting the Sequential Engagement of the IL-21 and IL-23 Pathways

D. Levy, W. Leonard, D. Littman, 2007 .

Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death

D. Levy, G. Inghirami, Yan Fan, 2002, Oncogene.

STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2.

D. Levy, R. Raz, C. Basilico, 2001, Development.

FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway.

D. Levy, D. Ambrosetti, C. Basilico, 1999, Genes & development.

Transcription of interferon-stimulated genes is induced by adenovirus particles but is suppressed by E1A gene products

J. Darnell, D. Levy, N. Reich, 1988, Journal of virology.

Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation.

D. Levy, J. Schlessinger, C. Schindler, 1993, Science.

Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation.

D. Levy, G. Stark, S. Staugaitis, 2005, Cancer research.

Stat2 Is a Transcriptional Activator That Requires Sequence-specific Contacts Provided by Stat1 and p48 for Stable Interaction with DNA*

D. Levy, H. Bluyssen, 1997, The Journal of Biological Chemistry.

Retinoic Acid Induces Signal Transducer and Activator of Transcription ( STAT ) I , STAT 2 , and p 48 Expression in Myeloid Leukemia Cells and Enhances Their Responsiveness to lnterferons 1

D. Levy, A. Lehtonen, T. Ronni, 2005 .

Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells1

D. G. Zisoulis, D. Levy, M. Kaplan, 2007, The Journal of Immunology.

What does Stat 3 do ?

D. Levy, Chien-Kuo Lee, 2002 .

Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells

D. Levy, E. Laurini, S. Pricl, 2017, Proceedings of the National Academy of Sciences.

STAT1 acts as a tumor promoter for leukemia development.

David E Levy, Michael Freissmuth, Boris Kovacic, 2006, Cancer cell.

STAT 1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF 2

D. Levy, R. Raz, C. Basilico, 2001 .

Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.

D. Levy, D. Kessler, X. Fu, 1990, Genes & development.

Essential Role of STAT3 in Postnatal Survival and Growth Revealed by Mice Lacking STAT3 Serine 727 Phosphorylation

J. Darnell, D. Levy, E. Meffre, 2004, Molecular and Cellular Biology.

STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.

D. Levy, J. Engelman, J. Settleman, 2011, Cancer research.

Cytokines and growth factors signal through tyrosine phosphorylation of a family of related transcription factors.

D. Levy, J. Ihle, T. Decker, 1994, Immunity.

Influenza virus targets the mRNA export machinery and the nuclear pore complex

David E. Levy, D. Levy, Yaming Wang, 2007, Proceedings of the National Academy of Sciences.

Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells.

D. Levy, C. Mathieu, D. Eizirik, 2005, Diabetes.

Disruption of the-Interferon Signaling Pathway at the Level of Signal Transducer and Activator of Transcription-1 Prevents Immune Destruction of-cells

D. Levy, C. Mathieu, D. Eizirik, 2005 .

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation1

D. Levy, E. Bottinger, W. Ju, 2009, The Journal of Immunology.

Two domains of ISGF3 gamma that mediate protein-DNA and protein-protein interactions during transcription factor assembly contribute to DNA-binding specificity

D. Levy, D. Levy, S. Veals, 1993, Molecular and cellular biology.

ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains.

J. Darnell, D. Levy, Xin-Yuan Fu, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Role of Nucleoporin Induction in Releasing an mRNA Nuclear Export Block

G. Blobel, D. Levy, B. Fontoura, 2002, Science.

Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity.

D. Levy, A. Prakash, I. Marié, 2003, Current opinion in immunology.

Distinct Requirements for IFNs and STAT1 in NK Cell Function1

David E. Levy, D. Levy, A. Frey, 2000, The Journal of Immunology.

Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor

D. Levy, G. Stark, I. Kerr, 1996, Molecular and cellular biology.

Retinoic acid induces signal transducer and activator of transcription (STAT) 1, STAT2, and p48 expression in myeloid leukemia cells and enhances their responsiveness to interferons.

D. Levy, K. Melén, I. Julkunen, 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Acetylation of Interferon Regulatory Factor-7 by p300/CREB-binding Protein (CBP)-associated Factor (PCAF) Impairs its DNA Binding*

D. Levy, A. Masumi, Eric J. Smith, 2002, The Journal of Biological Chemistry.

ACETYLATION OF INTERFERON REGULATORY FACTOR-7 BY PCAF IMPAIRS ITS DNA BINDING*

D. Levy, A. Masumi, G. Ara, 2002 .

Phosphorylation-Induced Dimerization of Interferon Regulatory Factor 7 Unmasks DNA Binding and a Bipartite Transactivation Domain

D. Levy, Eric J. Smith, A. Prakash, 2000, Molecular and Cellular Biology.

ISGF3γ p48, a specificity switch for interferon activated transcription factors

D. Levy, H. Bluyssen, J. Durbin, 1996 .

Interferon induction of gene expression through the Jak–Stat pathway

D. Levy, 1995 .

Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either

J. Darnell, D. Levy, D. Kessler, 1990, Molecular and cellular biology.

Functional Crosstalk between Type I and II Interferon through the Regulated Expression of STAT1

D. Levy, J. Trapani, K. Sabapathy, 2010, PLoS biology.

Interferon-dependent transcriptional activation: signal transduction without second messenger involvement?

J. Darnell, D. Levy, Darnell Je, 1990, The New biologist.

Stat Protein Transactivation Domains Recruit p300/CBP through Widely Divergent Sequences*

D. Levy, A. Mui, S. Guadagno, 1999, The Journal of Biological Chemistry.

How Viruses Elicit Interferon Production

D. Levy, I. Marié, I. Marié, 2005 .

Reduced STAT3 activity in mice mimics clinical disease syndromes.

J. Darnell, D. Levy, K. L. La Perle, 2005, Biochemical and biophysical research communications.

IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff

D. Levy, M. Paulson, Eric J. Smith, 2002, Nature Cell Biology.

Activation of Stat 3 in renal tumors

D. Levy, J. Melamed, Peng Lee, 2009 .

Specificity of signaling by STAT1 depends on SH2 and C‐terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression

D. Levy, T. Decker, Mathias Müller, 2001, The EMBO journal.

Nuclear and cytoplasmic mRNA quantification by SYBR green based real-time RT-PCR.

D. Levy, Yaming Wang, Wei Zhu, 2006, Methods.

Activation of Mitogen-activated Protein Kinase Kinase (MKK) 3 and MKK6 by Type I Interferons*

D. Levy, M. Gaestel, L. Platanias, 2005, Journal of Biological Chemistry.

Regulation of Stat3 transcriptional activity by the conserved LPMSP motif for OSM and IL‐6 signaling

D. Levy, J. J. Zhang, M. Snyder, 2006, FEBS letters.

Distinct Inflammatory Signals Have Physiologically Divergent Effects on Epigenetic Regulation of Foxp3 Expression and Treg Function

D. Levy, J. Bromberg, N. Yin, 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells

D. Levy, M. Kaplan, Evelyn T. Nguyen, 2009, Immunology.

Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-α-producing and partially matured phenotype.

D. Levy, M. Markowitz, L. Rolnitzky, 2011, The Journal of clinical investigation.

Tissue-specific Positive Feedback Requirements for Production of Type I Interferon following Virus Infection*

D. Levy, Eric J. Smith, Chien-Kuo Lee, 2005, Journal of Biological Chemistry.

Whence Interferon? Variety in the Production of Interferon in Response to Viral Infection

D. Levy, 2002, The Journal of experimental medicine.

Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome

D. Levy, P. Chattopadhyay, G. Silverman, 2021, bioRxiv.

Survey IFNg signaling—Does it mean JAK-STAT?

D. Levy, R. Johnstone, D. Gough, 2008 .

Stat1 and Stat2 but Not Stat3 Arbitrate Contradictory Growth Signals Elicited by Alpha/Beta Interferon in T Lymphocytes

D. Levy, C. Schindler, R. Gimeno, 2005, Molecular and Cellular Biology.

New and Old Functions of STAT3: A Pivitol Target for Individualized Treatment of Cancer

D. Levy, G. Inghirami, R. Chiarle, 2005, Cell cycle.

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction

J. Turkson, P. Provero, D. Levy, 2010, Aging.

Enhancement and diversification of IFN induction by IRF-7-mediated positive feedback.

D. Levy, Eric J. Smith, A. Prakash, 2002, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

The Human RVB Complex Is Required for Efficient Transcription of Type I Interferon-Stimulated Genes

D. Levy, P. Mita, Leonid Gnatovskiy, 2013, Molecular and Cellular Biology.

Cells resistant to interferon are defective in activation of a promoter‐binding factor.

D. Levy, L. Pfeffer, R. Pine, 1988, The EMBO journal.

STAT Transcriptional Activation Mechanisms

D. Levy, 2003 .

Physiological significance of STAT proteins: investigations through gene disruption in vivo

D. Levy, D. E. Levy, 1999, Cellular and Molecular Life Sciences CMLS.

Activation of the JAK-STAT signal transduction pathway by oncostatin-M cultured human and mouse osteoblastic cells.

R. Baron, D. Levy, C. Schindler, 1996, Endocrinology.

Cytoplasmic transcription factors: mediators of cytokine signaling.

D. Levy, H. Bluyssen, J. Durbin, 1995, Agents and actions. Supplements.

Regulation of Interferon-α Responsiveness by the Duration of Janus Kinase Activity*

D. Levy, H. Bluyssen, Chien-Kuo Lee, 1997, The Journal of Biological Chemistry.

NF-kappaB-ISGF3 transcription factor cooperation: coincidence detector or memory chip?

D. Levy, 2010, Immunity.

Nucleoporin levels regulate cell cycle progression and phase-specific gene expression.

D. Levy, Yaming Wang, B. Fontoura, 2008, Developmental cell.

Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes.

J. Darnell, D. Levy, D. Kessler, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Analysis of Interferon-Regulated Proteins Binding the Interferon-α-Stimulated Response Element

D. Levy, 1998 .

Regulatory Serine Residues Mediate Phosphorylation-dependent and Phosphorylation-independent Activation of Interferon Regulatory Factor 7*

D. Levy, A. Hovanessian, I. Marié, 2005, Journal of Biological Chemistry.

A novel role for STAT1 in regulating murine erythropoiesis: deletion of STAT1 results in overall reduction of erythroid progenitors and alters their distribution.

David E Levy, D. Levy, D. Barber, 2005, Blood.

Production of Type I IFN Sensitizes Macrophages to Cell Death Induced by Listeria monocytogenes1

D. Levy, T. Decker, T. Chakraborty, 2002, The Journal of Immunology.

Three distinct loci on human chromosome 21 contribute to interferon-α/β responsiveness

D. Levy, R. Raz, L. Ling, 1995, Somatic cell and molecular genetics.

Superantigen-activated T cells redirected by a bispecific antibody inhibit vesicular stomatitis virus replication in vitro and in vivo.

D. Levy, A. Fernández-Sesma, D. Levy, 1998, Journal of immunology.

Virus Replication In Vitro and In Vivo Bispecific Antibody Inhibit Vesicular Stomatitis Superantigen-Activated T Cells Redirected

D. Levy, A. Fernández-Sesma, T. Moran, 1998 .

Cytoplasmic, full length and novel cleaved variant, TBLR1 reduces apoptosis in prostate cancer under androgen deprivation

D. Levy, Xin Li, R. Schneider, 2016, Oncotarget.

Virus infection and interferon can activate gene expression through a single synthetic element, but endogenous genes show distinct regulation.

D. Levy, J. Engelhardt, N. Raj, 1989, The Journal of biological chemistry.

Activation of Acute Phase Response Factor (APRF)/Stat3 Transcription Factor by Growth Hormone (*)

D. Levy, D. Meyer, J. Schwartz, 1995, The Journal of Biological Chemistry.

STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.

D. Levy, I. Aifantis, C. Lobry, 2014, Blood.

Differential regulation of TSG‐14 expression in murine fibroblasts and peritoneal macrophages

D. Levy, L. Reis, J. Vilček, 2000, Journal of leukocyte biology.

Activation of the signal transducer and transcription (STAT) signaling pathway in a primary T cell response. Critical role for IL-6.

D. Levy, O. Silvennoinen, M. Hurme, 1995, Journal of immunology.

A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3

D. Levy, D. Gough, C. White, 2015, Molecular and Cellular Biology.

Contribution of a TANK-Binding Kinase 1–Interferon (IFN) Regulatory Factor 7 Pathway to IFN-γ-Induced Gene Expression

David E. Levy, D. Levy, T. Decker, 2012, Molecular and Cellular Biology.

STAT3 Inhibitor OPB-51602 Is Cytotoxic to Tumor Cells Through Inhibition of Complex I and ROS Induction

D. Levy, M. Cammer, Lara Brambilla, 2020, iScience.

Nongenomic Functions of STAT3

D. Levy, P. Sehgal, D. Gough, 2012 .

STAT3: A multifaceted oncogene

D. Levy, G. Inghirami, 2006, Proceedings of the National Academy of Sciences.

The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity

D. Levy, Hongbo Hu, Shao-Cong Sun, 2017, The Journal of experimental medicine.

The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions.

D. Levy, A. Kamphorst, Y. Chook, 2006, Immunity.

The Proximal Tyrosines of the Cytoplasmic Domain of the β Chain of the Type I Interferon Receptor Are Essential for Signal Transducer and Activator of Transcription (Stat) 2 Activation

D. Levy, L. Platanias, S. Uddin, 1999, The Journal of Biological Chemistry.

Protein kinase activity required for an early step in interferon-alpha signaling.

D. Levy, D. Kessler, 1991, The Journal of biological chemistry.

Regulation of interferon-alpha responsiveness by the duration of Janus kinase activity.

D. Levy, H. Bluyssen, C. K. Lee, 1997, The Journal of biological chemistry.

Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.

D. Levy, G. Stark, I. Kerr, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Stat Acetylation--A Key Facet of Cytokine Signaling?

Xiaomin Chen, D. Levy, J. O’Shea, 2005, Science.

Tumor and Stem Cell Biology STAT 3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis

D. Levy, J. Engelman, J. Settleman, 2011 .

C. elegans STAT: evolution of a regulatory switch

D. Levy, Yaming Wang, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The WD Motif-Containing Protein RACK-1 Functions as a Scaffold Protein Within the Type I IFN Receptor-Signaling Complex 1

D. Levy, A. Usacheva, O. Colamonici, 2003, The Journal of Immunology.

C. elegans STAT Cooperates with DAF-7/TGF-β Signaling to Repress Dauer Formation

D. Levy, Yaming Wang, 2006, Current Biology.

C. elegans STAT cooperates with DAF-7/TGF-beta signaling to repress dauer formation.

D. Levy, Yaming Wang, 2006, Current Biology.

Signal Transducers and Activators of Transcription (STATs)

D. Levy, P. Sehgal, 平野俊夫, 2003, Springer Netherlands.

Role of p38α Map Kinase in Type I Interferon Signaling*

D. Levy, M. Gaestel, L. Platanias, 2004, Journal of Biological Chemistry.

Nuclear receptor coregulator (NRC): mapping of the dimerization domain, activation of p53 and STAT-2, and identification of the activation domain AD2 necessary for nuclear receptor signaling.

D. Levy, H. Samuels, Audrey Murray, 2007, Molecular endocrinology.

STAT3 signaling and the hyper-IgE syndrome.

D. Levy, C. Loomis, 2007, The New England journal of medicine.

STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis.

D. Levy, M. Kaplan, H. Broxmeyer, 2011, Blood.

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells.

D. Levy, D. Littman, Yaming Wang, 2010, Nature.

Transcriptional regulation of interferon-stimulated genes: a DNA response element and induced proteins that recognize it.

J. Darnell, D. Levy, N. Reich, 1988, Cold Spring Harbor symposia on quantitative biology.

mink cell focus-forming virus. to retroviral RNA containing segments identical Normal expression of polymorphic endogenous

R. Lerner, D. Levy, Michael C. Wilson, 2013 .

Role of p38alpha Map kinase in Type I interferon signaling.

D. Levy, M. Gaestel, L. Platanias, 2004, The Journal of biological chemistry.

Distinct Requirements for IFNs and STAT1 in NK Cell Function1

D. Levy, A. Frey, R. Gimeno, 2000, The Journal of Immunology.

Optimized production of the soluble human interferon a receptor (IFNAR) expressed in E. coli

D. Levy, M. Hirata, N. Nguyen, 1997 .

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction

J. Turkson, P. Provero, D. Levy, 2010, Aging.

STAT3 regulated ARF expression suppresses prostate cancer metastasis

D. Levy, R. Eferl, V. Poli, 2015, Nature Communications.

Cooperation between STAT3 and c-jun suppresses Fas transcription.

D. Levy, C. Horvath, L. Owen-Schaub, 2001, Molecular cell.

A novel interferon-alpha-regulated, DNA-binding protein participates in the regulation of the IFP53/tryptophanyl-tRNA synthetase gene.

D. Levy, C. Schindler, T. Decker, 1994, The Journal of biological chemistry.

STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas

R. Cardiff, D. Levy, R. Schreiber, 2012, Breast Cancer Research.

DCA promotes a novel tolerogenic program in CD 4 + T cells by inhibiting CDK 8

Kaitlin J. Flynn, R. Xavier, P. Linsley, 2019 .

Identification of a Stat3-dependent transcription regulatory network involved in metastatic progression.

D. Levy, M. Hallett, W. Muller, 2009, Cancer Research.

Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors.

J. Thierry-Mieg, D. Thierry-Mieg, D. Levy, 2009, Immunity.

Donor T cell STAT3 deficiency enables tissue PD-L1–dependent prevention of graft-versus-host disease while preserving graft-versus-leukemia activity

D. Levy, Xiwei Wu, Ubaydah Nasri, 2023, The Journal of clinical investigation.

The transcription factor STAT3 is required for T helper 2 cell development.

D. Levy, M. Kaplan, R. Goswami, 2011, Immunity.

IFNgamma signaling-does it mean JAK-STAT?

D. Levy, R. Johnstone, D. Gough, 2008, Cytokine & growth factor reviews.

Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity.

C. Rice, D. Levy, Michelle Holko, 2004, Proceedings of the National Academy of Sciences of the United States of America.

ISGF3 gamma p48, a specificity switch for interferon activated transcription factors.

D. Levy, J. Durbin, A. R. Bluyssen, 1996, Cytokine & growth factor reviews.

Signalling: STATs: transcriptional control and biological impact

D. Levy, J. E. Darnell, James E. Darnell, 2002, Nature Reviews Molecular Cell Biology.

Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-α-producing and partially matured phenotype.

D. Levy, M. Markowitz, L. Rolnitzky, 2011, The Journal of clinical investigation.

ACETYLATION OF INTERFERON REGULATORY FACTOR-7 BY PCAF IMPAIRS ITS DNA BINDING*

D. Levy, A. Masumi, G. Ara, 2002 .