R. Jove

发表

The STATs of cancer — new molecular targets come of age

Hua Yu, R. Jove, 2004, Nature Reviews Cancer.

RbAp48 regulates cytoskeletal organization and morphology by increasing K-Ras activity and signaling through mitogen-activated protein kinase.

T. Yeatman, R. Jove, A. Scuto, 2007, Cancer research.

Roles of Gab1 and SHP2 in Paxillin Tyrosine Dephosphorylation and Src Activation in Response to Epidermal Growth Factor*

R. Jove, Yuan Ren, Songshu Meng, 2004, Journal of Biological Chemistry.

Role of Stat3 in Regulating p53 Expression and Function

Hua Yu, R. Jove, Meijuan Huang, 2005, Molecular and Cellular Biology.

Src activation in melanoma and Src inhibitors as therapeutic agents in melanoma

Hua Yu, R. Jove, J. Homsi, 2009, Melanoma research.

A Direct Interaction between G-Protein βγ Subunits and the Raf-1 Protein Kinase (*)

R. Jove, H. Levine, K. Pumiglia, 1995, The Journal of Biological Chemistry.

Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation

J. Turkson, R. Jove, Tammy Bowman, 1998, Molecular and Cellular Biology.

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

L. Ellis, J. Turkson, D. Coppola, 2002, Oncogene.

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

W. Guida, J. Turkson, R. Jove, 2007, Proceedings of the National Academy of Sciences.

STATs in cancer inflammation and immunity: a leading role for STAT3

Hua Yu, R. Jove, D. Pardoll, 2009, Nature Reviews Cancer.

STAT proteins: novel molecular targets for cancer drug discovery

J. Turkson, R. Jove, 2000, Oncogene.

Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention.

R. Jove, R. Buettner, L. Mora, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

Mechanisms of Disease: insights into the emerging role of signal transducers and activators of transcription in cancer

Eric B Haura, J. Turkson, R. Jove, 2005, Nature Clinical Practice Oncology.

Revisiting STAT3 signalling in cancer: new and unexpected biological functions

Hua Yu, Andreas Herrmann, Hua Yu, 2014, Nature Reviews Cancer.

Biochemical properties of p60v-src mutants that induce different cell transformation parameters

H. Iba, R. Jove, H. Hanafusa, 1986, Journal of virology.

The protein-protein complex between pp60v-src and hsp90 is stabilized by molybdate, vanadate, tungstate, and an endogenous cytosolic metal.

R. Jove, W. Pratt, L. Stancato, 1992, The Journal of biological chemistry.

Reconstitution of the multiprotein complex of pp60src, hsp90, and p50 in a cell-free system.

R. Jove, W. Pratt, G. Perdew, 1992, The Journal of biological chemistry.

Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system.

R. Jove, W. Pratt, G. Perdew, 1993, The Journal of biological chemistry.

The native v-Raf.hsp90.p50 heterocomplex contains a novel immunophilin of the FK506 binding class.

R. Jove, W. Pratt, L. Stancato, 1994, The Journal of biological chemistry.

The hsp90-binding Antibiotic Geldanamycin Decreases Raf Levels and Epidermal Growth Factor Signaling without Disrupting Formation of Signaling Complexes or Reducing the Specific Enzymatic Activity of Raf Kinase*

R. Jove, A. Silverstein, W. Pratt, 1997, The Journal of Biological Chemistry.

STATs in oncogenesis

Roy Garcia, J. Turkson, R. Jove, 2000, Oncogene.

Activation of Stat3 in Primary Tumors from High-Risk Breast Cancer Patients Is Associated with Elevated Levels of Activated Src and Survivin Expression

Alan Cantor, Craig A. Beam, Marek Wloch, 2006, Clinical Cancer Research.

COHCAP: an integrative genomic pipeline for single-nucleotide resolution DNA methylation analysis

A. Riggs, Yate-Ching Yuan, Hua Yu, 2019, Nucleic acids research.

The pyrido[2,3-d]pyrimidine derivative PD180970 inhibits p210Bcr-Abl tyrosine kinase and induces apoptosis of K562 leukemic cells.

R. Jove, A. Kraker, J. Dorsey, 2000, Cancer research.

The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors.

Hua Yu, Hong Xin, Minwei Ye, 2009, Cancer cell.

Preliminary pharmacokinetic study of the anticancer 6BIO in mice using an UHPLC‐MS/MS approach

R. Jove, J. Tchoumtchoua, M. Halabalaki, 2019, Journal of pharmaceutical and biomedical analysis.

Inhibition of neurofibromin and p120 GTPase activating protein (GAP) by dietary fatty acids.

R. Jove, V. Sundaram, M. Golubić, 1999, Advances in experimental medicine and biology.

Differential regulation of neurofibromin and p120 GTPase-activating protein by nutritionally relevant fatty acids.

R. Jove, V. Sundaram, M. Golubić, 1998, Nutrition and cancer.

Carboxy-terminal truncated STAT5 is induced by interleukin-2 and GM-CSF in human neutrophils.

R. Jove, Sheng Wei, J. Djeu, 2002, Cellular immunology.

Regulation of the Cyclin D3 Promoter by E2F1*

R. Jove, Meijuan Huang, Yihong Ma, 2003, The Journal of Biological Chemistry.

SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells

R. Jove, A. Vultur, F. Boschelli, 2008, Molecular Cancer Therapeutics.

Transcription initiation by RNA polymerase II is inhibited by S-adenosylhomocysteine.

R. Jove, J. Manley, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Identification of Src transformation fingerprint in human colon cancer

John Quackenbush, Jennifer Tsai, Edison T Liu, 2002, Oncogene.

Cell transformation by the viral src oncogene.

R. Jove, H. Hanafusa, Hidesaburo Hanafusa, 1987, Annual review of cell biology.

Elevated c-Src protein expression is an early event in colonic neoplasia.

T. Yeatman, D. Coppola, R. Jove, 1998, Laboratory investigation; a journal of technical methods and pathology.

Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest.

R. Jove, G. Niu, W. Dalton, 2001, Cancer research.

Prostate adenocarcinoma: cellular and molecular abnormalities.

R. Jove, J. Seigne, R. Buettner, 2001, Cancer control : journal of the Moffitt Cancer Center.

Role of the cytoplasmic tyrosines of beta 1A integrins in transformation by v-src.

R. Jove, R. Fässler, D. Mosher, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Role of the cytoplasmic tyrosines of β1A integrins in transformation by v-src

R. Jove, R. Fässler, D. Mosher, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Activation of Phosphatidylinositol 3-Kinase/Akt Pathway by Androgen through Interaction of p85α, Androgen Receptor, and Src*

Lin Yang, S. Nicosia, J. Cheng, 2003, Journal of Biological Chemistry.

AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells.

S. Nicosia, J. Cheng, R. Jove, 1998, Cancer research.

Dissociation of Mitogen-activated Protein Kinase Activation from the Oxidative Burst in Differentiated HL-60 Cells and Human Neutrophils (*)

Hua Yu, R. Jove, R. Nairn, 1995, The Journal of Biological Chemistry.

Cooperative Regulation of Mcl-1 by Janus Kinase/STAT and Phosphatidylinositol 3-Kinase Contribute to Granulocyte-Macrophage Colony-Stimulating Factor-Delayed Apoptosis in Human Neutrophils1

R. Jove, B. Zhong, K. Jiang, 2001, The Journal of Immunology.

Apoptosis in Human Neutrophils Colony-Stimulating Factor-Delayed Granulocyte-Macrophage 3-Kinase Contribute to Kinase/STAT and Phosphatidylinositol Cooperative Regulation of Mcl-1 by Janus

R. Jove, B. Zhong, K. Jiang, 2001 .

Human topoisomerase IIα nuclear export is mediated by two CRM-1-dependent nuclear export signals

R. Jove, D. Sullivan, J. Turner, 2004, Journal of Cell Science.

Raf-1 N-terminal sequences necessary for Ras-Raf interaction and signal transduction

R. Jove, K. Pumiglia, J. Fabian, 1995, Molecular and cellular biology.

Activation of extracellular signal-regulated kinase (ERK) by mitogenic stimuli is repressed in v-Src-transformed cells.

R. Jove, C. Yu, J. Wu, 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Proximal promoter region of the junB gene mediates attenuation of serum inducibility in Src-transformed cells.

R. Jove, E. Prochownik, C. Yu, 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

The Src-family kinase Lck can induce STAT3 phosphorylation and DNA binding activity.

R. Jove, C. Coleman, B. Sefton, 1999, Cellular signalling.

Preface: STAT signaling

R. Jove, 2000, Oncogene.

Leukemia-Blast Crisis Cells Mesylate-sensitive or-refractory Chronic Myelogenous Bcr-Abl and Induces Apoptosis of Imatinib Expression and Promotes Proteasomal Degradation of Histone Deacetylase Inhibitor LAQ 824 Both Lowers

P. Atadja, R. Jove, Jie Wu, 2003 .

Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells.

P. Atadja, R. Jove, Jie Wu, 2003, Cancer research.

1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and activates apoptosis in melanoma.

R. Jove, S. Awasthi, S. Rahbar, 2012, Biochemical pharmacology.

In vivo phosphorylation states and kinase activities of transforming p60c-src mutants.

R. Jove, H. Hanafusa, M. Hamaguchi, 1989, Oncogene research.

Genetic analysis of p60v-src domains involved in the induction of different cell transformation parameters

H. Iba, R. Jove, B. Mayer, 1986, Journal of virology.

Characterization of avian and viral p60src proteins expressed in yeast.

R. Jove, H. Hanafusa, S. Kornbluth, 1987, Proceedings of the National Academy of Sciences of the United States of America.

The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation

F. Cross, R. Jove, H. Hanafusa, 1987, Journal of virology.

Activated Src tyrosine kinase phosphorylates Tyr-457 of bovine GTPase-activating protein (GAP) in vitro and the corresponding residue of rat GAP in vivo.

T. Pawson, R. Jove, X. Liu, 1992, The Journal of biological chemistry.

Activation of STAT3 by the c-Fes Protein-tyrosine Kinase*

R. Jove, T. Smithgall, Tammy Bowman, 1998, The Journal of Biological Chemistry.

Functional Mapping of the N-terminal Regulatory Domain in the Human Raf-1 Protein Kinase (*)

R. Jove, P. Dent, T. Sturgill, 1995, The Journal of Biological Chemistry.

Targeting JAK1/STAT3 Signaling Suppresses Tumor Progression and Metastasis in a Peritoneal Model of Human Ovarian Cancer

R. Jove, A. Scuto, S. Forman, 2014, Molecular Cancer Therapeutics.

miR-302 b maintains “ stemness ” of human embryonal carcinoma cells by post-transcriptional regulation of Cyclin D 2 expression

R. Jove, S. Moon, M. Behlke, 2008 .

Expression, purification and characterization of recombinant mitogen-activated protein kinase kinases.

R. Jove, D. Morrison, P. Dent, 1994, The Biochemical journal.

The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells.

P. Atadja, R. Jove, Y. Yen, 2007, Blood.

in Cancer Abnormal Differentiation of Dendritic Cells Hyperactivation of STAT3 Is Involved in

R. Jove, D. Gabrilovich, P. Cheng, 2003 .

Regulation of Glucocorticoid Receptor Function through Assembly of a Receptor‐Heat Shock Protein Complex a

R. Jove, W. Pratt, L. Stancato, 1993, Annals of the New York Academy of Sciences.

Effects of dasatinib on SRC kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells.

R. Jove, M. Copland, T. Holyoake, 2008, Cancer research.

Constitutive RelB activation in v‐Src‐transformed fibroblasts: Requirement for IκB degradation

R. Jove, N. Olashaw, K. Shain, 1999, Journal of cellular biochemistry.

RNA polymerase II terminates transcription in vitro in the SV40 origin region.

R. Jove, J. Manley, D. Grass, 1987, Nucleic acids research.

GTPase-activating protein interactions with the viral and cellular Src kinases.

R. Jove, J. Gibbs, B. Brott, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Molecular features of the viral and cellular Src kinases involved in interactions with the GTPase-activating protein

R. Jove, B. Brott, M. O'Brien, 1991, Molecular and cellular biology.

Localization of the viral and cellular Src kinases to perinuclear vesicles in fibroblasts.

R. Jove, M. Welsh, B. Brott, 1992, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Attenuation of serum inducibility of immediate early genes by oncoproteins in tyrosine kinase signaling pathways

R. Jove, E. Prochownik, M. Imperiale, 1993, Molecular and cellular biology.

Molecular Features oftheViral andCellular SrcKinases Involved inInteractions withtheGTPase-Activating Protein

R. Jove, S. Decker, 1991 .

Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck

R. Jove, R. Garcia, P. Medveczky, 1997, Journal of virology.

6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells.

R. Jove, A. Scuto, Fan Yang, 2011, Cancer research.

SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells

P. Atadja, R. Jove, A. Scuto, 2013, Cell Death and Disease.

leukemia cells DNA damage response genes and apoptosis in Ph- acute lymphoblastic The novel histone deacetylase inhibitor, LBH589, induces expression of

P. Atadja, R. Jove, Y. Yen, 2013 .

Corrigendum: Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

D. Coppola, Hua Yu, R. Jove, 2004, Nature Network Boston.

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

J. Turkson, R. Jove, A. Cantor, 2003, Cancer research.

Tumor and Stem Cell Biology LossofAndrogenReceptorExpressionPromotesaStem-like Cell Phenotype in Prostate Cancer through STAT3 Signaling

Hua Yu, R. Jove, S. Pal, 2014 .

B 1 Integrin Adhesion Enhances IL-6–Mediated STAT3 Signaling in Myeloma Cells: Implications for Microenvironment Influence on Tumor Survival and Proliferation

R. Jove, W. Dalton, L. Hazlehurst, 2009 .

3-O-methylthespesilactam, a new small-molecule anticancer pan-JAK inhibitor against A2058 human melanoma cells.

Qiang Xiao, Lucy Liu, Yate-Ching Yuan, 2013, Biochemical pharmacology.

Amphidinolide B: total synthesis, structural investigation, and biological evaluation.

R. Jove, Wei Zhang, Sangkil Nam, 2013, The Journal of organic chemistry.

Synthesis and anticancer activities of ageladine A and structural analogs.

R. Jove, Sangkil Nam, K. Yakushijin, 2010, Bioorganic & medicinal chemistry letters.

General approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors: enantioselective total syntheses of (+)- and (-)-gliocladine C, (+)-leptosin D, (+)-T988C, (+)-bionectin A, and (+)-gliocladin A.

Steven M. Mennen, L. Overman, R. Jove, 2013, Journal of the American Chemical Society.

An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects.

William P. Katt, J. Turkson, R. Jove, 2007, ACS chemical biology.

Cytotoxic prenylated acetophenone dimers from Acronychia pedunculata.

R. Jove, A. Skaltsounis, M. Halabalaki, 2012, Journal of natural products.

Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling

R. Jove, A. Scuto, Xinlai Cheng, 2012, Molecular oncology.

Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein

J. Turkson, R. Jove, Jie Wu, 1999, Molecular and Cellular Biology.

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity

D. Coppola, R. Jove, S. Sebti, 2008, Oncogene.

Neurofibromatosis type 1 gene product (neurofibromin) associates with microtubules

M. Boguski, F. Collins, T. Jacks, 1993, Somatic cell and molecular genetics.

Immunotherapy as part of a multidisciplinary approach to melanoma treatment.

R. Jove, A. Daud, A. Riker, 2006, Frontiers in bioscience : a journal and virtual library.

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells.

J. Turkson, G. Ciliberto, R. Jove, 1999, Immunity.

Activation of STAT transcription factors in oncogenic tyrosine kinase signaling.

R. Jove, R. Garcia, R. Garcia, 1998, Journal of biomedical science.

Bortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of AKT and NF-ĸB signaling, and synergizes with an ERK inhibitor.

R. Jove, Y. Yen, A. Scuto, 2012, Cancer biology & therapy.

Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling.

R. Jove, Jianming Lu, Sangkil Nam, 2010, Carcinogenesis.

Hyperactivation of STAT3 Is Involved in Abnormal Differentiation of Dendritic Cells in Cancer

R. Jove, Meijuan Huang, D. Gabrilovich, 2004, The Journal of Immunology.

Antitumor Activity of Targeting Src Kinases in Endothelial and Myeloid Cell Compartments of the Tumor Microenvironment

Hua Yu, R. Jove, Y. Yen, 2010, Clinical Cancer Research.

Multiple Myeloma: New Insights and Therapeutic Approaches.

R. Jove, W. Dalton, R. Kyle, 2000, Hematology. American Society of Hematology. Education Program.

Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors.

Hua Yu, R. Jove, A. Herrmann, 2009, Cancer cell.

A Novel Platinum Compound Inhibits Constitutive Stat3 Signaling and Induces Cell Cycle Arrest and Apoptosis of Malignant Cells*

J. Turkson, R. Jove, Shumin M. Zhang, 2005, Journal of Biological Chemistry.

Bioactive Cycloperoxides Isolated from the Puerto Rican Sponge Plakortis halichondrioides.

R. Jove, C. Jiménez-Romero, B. Vera, 2010, Journal of natural products.

Molecular characterization and sensitivity of STI-571 (imatinib mesylate, Gleevec)-resistant, Bcr-Abl-positive, human acute leukemia cells to SRC kinase inhibitor PD180970 and 17-allylamino-17-demethoxygeldanamycin.

R. Jove, K. Bhalla, Meijuan Huang, 2002, Cancer research.

Differences and similarities between cancer and somatic stem cells: therapeutic implications

R. Jove, V. Beljanski, K. Grinnemo, 2020, Stem cell research & therapy.

The Ras GTPase-activating Protein (GAP) Is an SH3 Domain-binding Protein and Substrate for the Src-related Tyrosine Kinase, Hck (*)

R. Jove, T. Smithgall, S. Briggs, 1995, Journal of Biological Chemistry.

Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas

R. Jove, J. Mirosevich, Fan Yang, 2008, Molecular Cancer Therapeutics.

Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.

R. Jove, S. Ethier, C. Yu, 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies?

Jeanne Kowalski, Linzhao Cheng, Takita Felder Sumter, 2008, Cancer research.

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

Hua Yu, Tianhong Wang, Maciej Kujawski, 2005, Nature Medicine.

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

Hua Yu, Domenico Coppola, Tianhong Wang, 2004, Nature Medicine.

Expression and role of Foxa proteins in prostate cancer

R. Jove, J. Mirosevich, R. Matusik, 2006, The Prostate.

JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance.

Hua Yu, Yuan Yuan, Rahul Jandial, 2018, Cell metabolism.

JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance.

Hua Yu, Yuan Yuan, Rahul Jandial, 2018, Cell metabolism.

miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis

R. Jove, Y. Yen, Z. Meng, 2014, Oncogene.

Overexpression of normal c-Src in poorly metastatic human colon cancer cells enhances primary tumor growth but not metastatic potential.

T. Yeatman, D. Coppola, R. Jove, 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Critical role of STAT3 in IL-6-mediated drug resistance in human neuroblastoma.

S. Groshen, Hua Yu, R. Jove, 2013, Cancer research.

Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation*

J. Turkson, R. Jove, A. Hamilton, 2001, The Journal of Biological Chemistry.

The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival

R. Jove, Y. Yen, A. Scuto, 2011, Leukemia.

TLR9 is critical for glioma stem cell maintenance and targeting.

G. Gallia, Hua Yu, R. Jove, 2014, Cancer research.

Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation

A. Riggs, Hua Yu, R. Jove, 2012, Proceedings of the National Academy of Sciences.

Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein

J. Turkson, R. Jove, A. Khaled, 2006, Molecular Cancer Therapeutics.

Inhibition of Bcr–Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells

Hua Yu, R. Jove, Jie Wu, 2002, Oncogene.

miR‐194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice

R. Jove, Z. Meng, Xiaosong Chen, 2010, Hepatology.

Signal Transducer and Activator of Transcription 3 Is Required for Hypoxia-Inducible Factor-1α RNA Expression in Both Tumor Cells and Tumor-Associated Myeloid Cells

Hua Yu, R. Jove, M. Kortylewski, 2008, Molecular Cancer Research.

Inhibition of the IL-6/STAT3 signaling pathway for therapeutic intervention in prostate carcinogenesis and cancer cell differentiation

R. Jove, A. Schröder, 2013 .

A critical role for Stat3 signaling in immune tolerance.

Hua Yu, Shizuo Akira, S. Akira, 2003, Immunity.

Spirooxindole Derivative SOID-8 Induces Apoptosis Associated with Inhibition of JAK2/STAT3 Signaling in Melanoma Cells

R. Jove, Fan Yang, R. Buettner, 2012, PloS one.

S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites.

R. Figlin, Hua Yu, R. Jove, 2012, Cancer cell.

COHCAP: an integrative genomic pipeline for single-nucleotide resolution DNA methylation analysis

Hua Yu, Charles D. Warden, Yate-Ching Yuan, 2013, Nucleic acids research.

Splicing pathways of SV40 mRNAs in X. laevis oocytes differ in their requirements for snRNPs

R. Jove, C. Prives, J. Manley, 1984, Cell.

Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein.

R. Jove, D. Meyer, J. Schwartz, 1995, Science.

Src family kinases promote AML cell survival through activation of signal transducers and activators of transcription (STAT).

R. Jove, F. Boschelli, A. List, 2008, Leukemia research.

Inhibition of Src Family Kinases with Dasatinib Blocks Migration and Invasion of Human Melanoma Cells

Tania Mesa, R. Jove, F. Lee, 2008, Molecular Cancer Research.

Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation.

R. Jove, Meijuan Huang, W. Dalton, 2009, Cancer research.

Analysis of p60v-src mutants carrying lesions involved in temperature sensitivity

R. Jove, B. Mayer, H. Hanafusa, 1987, Journal of virology.

Genetic lesions involved in temperature sensitivity of the src gene products of four Rous sarcoma virus mutants

R. Jove, B. Mayer, H. Hanafusa, 1986, Journal of virology.

Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells

J. Turkson, R. Jove, B. Elliott, 2004, Oncogene.

Necdin, a Negative Growth Regulator, Is a Novel STAT3 Target Gene Down-Regulated in Human Cancer

S. Eschrich, R. Jove, Yihong Ma, 2011, PloS one.

Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors

R. Jove, A. Kraker, J. Cunnick, 2002, Leukemia.

Role of Tyrosine Kinase Activity of Epidermal Growth Factor Receptor in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Pathway*

J. Turkson, R. Jove, Jie Wu, 1998, The Journal of Biological Chemistry.

Spontaneous activation and signaling by overexpressed epidermal growth factor receptors in glioblastoma cells

R. Jove, R. Wharen, S. Parsons, 2003, International journal of cancer.

Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis.

R. Jove, H. Yamaguchi, K. Bhalla, 2003, Cancer research.

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

G. Semenza, J. Turkson, J. Cheng, 2005, Oncogene.

Regulates Cytoskeletal Organization and Morphology by Increasing KRas Activity and Signaling through Mitogen-Activated Protein Kinase

T. Yeatman, R. Jove, A. Scuto, 2007 .

Molecular Cloning and Characterization of the Human AKT1 Promoter Uncovers Its Up-regulation by the Src/Stat3 Pathway*

S. Nicosia, J. Cheng, Hua Yu, 2005, Journal of Biological Chemistry.

Prediction of radiation sensitivity using a gene expression classifier.

Steven Eschrich, Timothy Yeatman, T. Yeatman, 2005, Cancer research.

Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells

J. Turkson, R. Jove, J. Karras, 2003, Oncogene.

Persistent Activation of Stat3 Signaling Induces Survivin Gene Expression and Confers Resistance to Apoptosis in Human Breast Cancer Cells

S. Eschrich, J. Turkson, R. Jove, 2006, Clinical Cancer Research.

Synergistic anti-tumor effect of combined inhibition of EGFR and JAK/STAT3 pathways in human ovarian cancer

R. Jove, J. Yim, Jun Wu, 2015, Molecular Cancer.

Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis

R. Jove, G. Woude, Ling-mei Wang, 2002, Oncogene.

Increasing Antitumor Activity of JAK Inhibitor by Simultaneous Blocking Multiple Survival Signaling Pathways in Human Ovarian Cancer

R. Jove, J. Yim, Jun Wu, 2019, Translational oncology.

Ruxolitinib synergistically enhances the anti-tumor activity of paclitaxel in human ovarian cancer

R. Jove, J. Yim, Jun Wu, 2018, Oncotarget.

Activating SRC mutation in a subset of advanced human colon cancers

Timothy J. Yeatman, Domenico Coppola, T. Yeatman, 1999, Nature Genetics.

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression.

J. Turkson, R. Jove, Jin Hong Liu, 2001, The Journal of clinical investigation.

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells.

J E Paciga, S. Nicosia, J. Cheng, 2001, The American journal of pathology.

Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels.

R. Jove, Y. Yen, A. Scuto, 2011, Cancer research.

Transcription of methylated eukaryotic viral genes in a soluble in vitro system.

R. Jove, J. Manley, D. Sperber, 1984, Nucleic acids research.

Two SH2 Domains of p120 Ras GTPase-activating Protein Bind Synergistically to Tyrosine Phosphorylated p190 Rho GTPase-activating Protein (*)

R. Jove, F. McCormick, T. Smithgall, 1995, The Journal of Biological Chemistry.

STAT Proteins as Molecular Targets for Cancer Therapy

Hua Yu, R. Jove, M. Kortylewski, 2003 .

Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

Hua Yu, R. Jove, A. Chang, 2002, Oncogene.

Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.

J. Turkson, R. Jove, Meijuan Huang, 2004, Molecular cancer therapeutics.

Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region

R. Jove, H. Hanafusa, S. Kornbluth, 1987, Cell.

Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells.

J. Cheng, R. Jove, J. Mirosevich, 2005, Cancer research.

Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival.

R. Jove, F. Lee, C. Muro-Cacho, 2007, Cancer research.

Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

J. Turkson, J. Cheng, R. Jove, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of JAK kinase activity enhances Fas-mediated apoptosis but reduces cytotoxic activity of topoisomerase II inhibitors in U266 myeloma cells.

R. Jove, W. Dalton, L. Hazlehurst, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

Hua Yu, R. Jove, G. Niu, 2001, Oncogene.

Activated STAT3 as a correlate of distant metastasis in prostate cancer: a secondary analysis of Radiation Therapy Oncology Group 86-10.

R. Jove, J. Torres-Roca, H. Sandler, 2007, Urology.

Targeting STAT3 affects melanoma on multiple fronts

Hua Yu, R. Jove, M. Kortylewski, 2005, Cancer and Metastasis Reviews.

Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling.

Hua Yu, R. Jove, G. Müller-Newen, 2014, Cancer research.

Stat3-induced S1PR1 expression is critical for persistent Stat3 activation in tumors

Hua Yu, R. Jove, A. Herrmann, 2010, Nature Medicine.

Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells.

J. Pow-Sang, R. Jove, A. Cantor, 2002, Cancer research.

Cytoplasmic transport of Stat3 by receptor‐mediated endocytosis

J. Turkson, A. Bild, R. Jove, 2002, The EMBO journal.

Therapeutics , Targets , and Chemical Biology TLR 9 Is Critical for Glioma Stem Cell Maintenance and Targeting

G. Gallia, Hua Yu, R. Jove, 2014 .

A Novel Berbamine Derivative Inhibits Cell Viability and Induces Apoptosis in Cancer Stem-Like Cells of Human Glioblastoma, via Up-Regulation of miRNA-4284 and JNK/AP-1 Signaling

R. Jove, Fan Yang, R. Hickey, 2014, PloS one.

G-protein-coupled Receptor Agonist BV8/Prokineticin-2 and STAT3 Protein Form a Feed-forward Loop in Both Normal and Malignant Myeloid Cells*

Hua Yu, R. Jove, Chunyan Zhang, 2013, The Journal of Biological Chemistry.

Tumor and Stem Cell Biology LossofAndrogenReceptorExpressionPromotesaStem-like Cell Phenotype in Prostate Cancer through STAT 3 Signaling

Hua Yu, R. Jove, A. Herrmann, 2014 .

1 Loss of Androgen Receptor Expression Promotes a Stem-Like Cell Phenotype in Prostate Cancer through STAT 3 Signaling

Hua Yu, R. Jove, G. Müller-Newen, 2013 .

Sorafenib Induces Growth Arrest and Apoptosis of Human Glioblastoma Cells through the Dephosphorylation of Signal Transducers and Activators of Transcription 3

R. Jove, A. Scuto, Fan Yang, 2010, Molecular Cancer Therapeutics.

CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer.

Hua Yu, R. Jove, H. Xin, 2016, Immunity.

Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival.

R. Jove, F. Lee, E. Haura, 2006, Cancer research.

Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells.

R. Jove, D. Perrotti, S. Forman, 2014, Blood.

growth and maintenance of human acute myeloid leukemia stem cells Role of altered growth factor receptor-mediated JAK2 signaling in

R. Jove, S. Forman, R. Bhatia, 2014 .

Stat3 activity is required for gap junctional permeability in normal rat liver epithelial cells.

R. Jove, M. Geletu, A. Vultur, 2009, DNA and cell biology.

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

T. Yeatman, R. Jove, R. Irby, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling

J. Turkson, R. Jove, W. Wharton, 2000, Oncogene.

STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription.

R. Jove, W. Dalton, W S Dalton, 1999, Current opinion in oncology.

Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo.

M. Jaroszeski, D. Coppola, Hua Yu, 1999, Cancer research.

STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells.

R. Jove, L. Koenderman, R. de Groot, 1999, Blood.

Constitutive activation of the JAK2/STAT5 signal transduction pathway correlates with growth factor independence of megakaryocytic leukemic cell lines.

R. Jove, K. Zuckerman, R. Liu, 1999, Blood.

Constitutive Activation of the JAK 2 / STAT 5 Signal Transduction Pathway Correlates With Growth Factor Independence of Megakaryocytic Leukemic Cell Lines

R. Jove, K. Zuckerman, Richard Y. Liu, 1999 .

STAT 5 Activation by BCR-Abl Contributes to Transformation of K 562 Leukemia Cells

J. Lammers, R. Jove, L. Koenderman, 1999 .

Advances in Brief Gene Therapy with Dominant-negative Stat 3 Suppresses Growth of the Murine Melanoma B 16 Tumor in Vivo 1

M. Jaroszeski, D. Coppola, Hua Yu, 1999 .

Activation of STAT Transcription Factors in Oncogenic Tyrosine Kinase Signaling

R. Jove, R. Garcia, 1998, Journal of Biomedical Science.

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity

D. Coppola, R. Jove, S. Sebti, 2005, Oncogene.

Activation of Stat3 preassembled with platelet-derived growth factor β receptors requires Src kinase activity

R. Jove, A. Kraker, W. Wharton, 2000, Oncogene.

Natural-Based Indirubins Display Potent Cytotoxicity toward Wild-Type and T315I-Resistant Leukemia Cell Lines.

R. Jove, A. Skaltsounis, E. Mikros, 2016, Journal of natural products.

Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively‐activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells

Yate-Ching Yuan, Hua Yu, R. Jove, 2013, Molecular oncology.

Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells

R. Jove, Fan Yang, Yan Wang, 2012, Molecular oncology.

Stat3 regulates genes common to both wound healing and cancer

R. Jove, S. Enkemann, E. Haura, 2005, Oncogene.

Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors

R. Jove, A. Levitzki, R. Karni, 1999, Oncogene.

Combination therapy with AG-490 and interleukin 12 achieves greater antitumor effects than either agent alone.

D. Coppola, Hua Yu, R. Jove, 2002, Molecular cancer therapeutics.

Advances in Brief Overexpression of a Dominant-Negative Signal Transducer and Activator of Transcription 3 Variant in Tumor Cells Leads to Production of Soluble Factors That Induce Apoptosis and Cell Cycle Arrest 1

Hua Yu, R. Jove, Meijuan Huang, 2001 .

Convection-enhanced delivery of sorafenib and suppression of tumor progression in a murine model of brain melanoma through the inhibition of signal transducer and activator of transcription 3.

R. Jove, R. Jandial, Fan Yang, 2016, Journal of neurosurgery.

Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential

Hua Yu, Marek Wloch, Roy Garcia, 1997, Oncogene.

Upregulation of Fanconi Anemia DNA Repair Genes in Melanoma Compared to Non-Melanoma Skin Cancer

Pascal O. Zinn, Richard D. Kennedy, Adam I. Riker, 2011, The Journal of investigative dermatology.

STAT3 inhibition is a therapeutic strategy for ABC-like diffuse large B-cell lymphoma.

Hua Yu, R. Jove, A. Scuto, 2011, Cancer research.

Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen.

J. Turkson, R. Jove, G. Niu, 2005, Molecular biology of the cell.

A novel synthetic derivative of the natural product berbamine inhibits cell viability and induces apoptosis of human osteosarcoma cells, associated with activation of JNK/AP-1 signaling

R. Jove, Fan Yang, Yan Tian, 2013, Cancer biology & therapy.

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

Hua Yu, Drew M. Pardoll, John J. Rossi, 2009, Nature Biotechnology.

JAK/STAT Signaling in Myeloid Cells

Hua Yu, R. Jove, S. Priceman, 2013 .

Chapter 26 – JAK/STAT Signaling in Myeloid Cells: Targets for Cancer Immunotherapy

Hua Yu, R. Jove, S. Priceman, 2013 .

Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells.

R. Jove, S. Ethier, C. Sartor, 1997, Cancer research.

Synergistic Anti-Tumor Activity by Targeting Multiple Signaling Pathways in Ovarian Cancer

R. Jove, J. Yim, Jun Wu, 2020, Cancers.

Prediction of Radiation Sensitivity Using a Gene

T. Yeatman, S. Eschrich, R. Jove, 2005 .

Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity.

J. Turkson, Hua Yu, R. Jove, 2004, Molecular cancer therapeutics.

Erratum: JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance (Cell Metabolism (2018) 27(1) (136–150.e5)(S1550413117306691)(10.1016/j.cmet.2017.11.001))

Hua Yu, Yuan Yuan, Rahul Jandial, 2018 .

Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance

A. Riggs, Hua Yu, R. Jove, 2013, Proceedings of the National Academy of Sciences.

In vitro transcription from the adenovirus 2 major late promoter utilizing templates truncated at promoter-proximal sites.

R. Jove, J. Manley, 1984, The Journal of biological chemistry.

Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480.

R. Figlin, Hua Yu, R. Jove, 2011, Cancer research.

Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains.

William P. Katt, J. Turkson, R. Jove, 2007, Bioorganic & medicinal chemistry letters.

MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids.

R. Jove, F. Pattou, D. Moore, 2015, The Journal of clinical investigation.

TLR agonist–Stat3 siRNA conjugates: cell-specific gene silencing and enhanced antitumor immune responses

Hua Yu, R. Jove, A. Scuto, 2009, Nature biotechnology.

Prognostic Significance of Neutrophilic Infiltration in Benign Lymph Nodes in Patients with Muscle-invasive Bladder Cancer.

R. Jove, D. McConkey, S. Lerner, 2017, European urology focus.

STAT3 nuclear egress requires exportin 7 via engaging lysine acetylation

Hua Yu, R. Jove, A. Herrmann, 2014 .

Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2.

R. Jove, Sheng Wei, B. Chu, 2003, Cancer research.

Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development.

Yate-Ching Yuan, R. Jove, N. Vaidehi, 2011, ACS chemical biology.

AG490 inhibits G1-S traverse in BALB/c-3T3 cells following either mitogenic stimulation or exogenous expression of E2F-1.

R. Jove, P. Moseley, Yihong Ma, 2004, Molecular cancer therapeutics.

Roscovitine Inhibits STAT 5 Activity and Induces Apoptosis in the Human Leukemia Virus Type 1-Transformed Cell Line MT2

R. Jove, Sheng Wei, B. Chu, 2003 .

Drug resistance in multiple myeloma: approaches to circumvention.

R. Jove, W. Dalton, 1999, Seminars in oncology.

Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells

David D. Smith, R. Jove, K. Bhalla, 2007, Molecular Cancer Therapeutics.

Cancer Biology and Signal Transduction Targeting JAK 1 / STAT 3 Signaling Suppresses Tumor Progression and Metastasis in a Peritoneal Model of Human Ovarian Cancer

R. Jove, A. Scuto, S. Forman, 2014 .

Activated stat-3 in melanoma.

Hua Yu, R. Jove, P. Munster, 2008, Cancer control : journal of the Moffitt Cancer Center.

Activated Stat3 in Melanoma

Hua Yu, R. Jove, P. Munster, 2008 .

Targeting JAK 1 / STAT 3 signaling suppresses tumor progression and metastasis in a peritoneal model of human ovarian cancer

R. Jove, A. Scuto, S. Forman, 2014 .

Signal Transduction Proteins in Tumors From Puerto Rican and Caucasian Gastric Adenocarcinoma Patients: Expression Differences With Potential for Specific Targeted Therapies

R. Jove, D. Sullivan, C. Muro-Cacho, 2008, Digestive Diseases and Sciences.

Regulation of the junB gene by v-src

R. Jove, E. Prochownik, C. Yu, 1992, Molecular and cellular biology.

MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cells

R. Jove, Jun Wu, L. Skaltsounis, 2014, Cancer biology & therapy.

A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling

R. Jove, Fan Yang, Yan Wang, 2012, Cancer biology & therapy.

Humanized Lewis-Y specific antibody based delivery of STAT3 siRNA.

A. Simpson, A. Scott, R. Jove, 2011, ACS chemical biology.

Therapeutics , Targets , and Chemical Biology 6-Bromoindirubin-3 0-Oxime Inhibits JAK / STAT 3 Signaling and Induces Apoptosis of Human Melanoma Cells

R. Jove, A. Scuto, Fan Yang, 2011 .

Microenvironment and Immunology Antiangiogenic and Antimetastatic Activity of JAK Inhibitor AZD 1480

R. Figlin, Hua Yu, R. Jove, 2011 .

STAT 3 Inhibition Is a Therapeutic Strategy for ABC-like Diffuse Large B-Cell Lymphoma

Hua Yu, R. Jove, A. Scuto, 2011 .

Constitutive Activation of Stat 3 in Human Prostate Tumors and Cell Lines : Direct Inhibition of Stat 3 Signaling Induces Apoptosis of Prostate Cancer Cells 1

J. Pow-Sang, R. Jove, A. Cantor, 2002 .

Historical Development of STAT3 Inhibitors and Early Results in Clinical Trials

J. Turkson, R. Jove, Chao-Lan Yu, 2016 .

STAT3 Activation by Type I Interferons Is Dependent on Specific Tyrosines Located in the Cytoplasmic Domain of Interferon Receptor Chain 2c

J. Turkson, R. Jove, E. Croze, 2002, The Journal of Biological Chemistry.

Activation of Stat3 in v-Src-transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity*

J. Turkson, R. Jove, A. Kraker, 2000, The Journal of Biological Chemistry.

miR-302b maintains "stemness" of human embryonal carcinoma cells by post-transcriptional regulation of Cyclin D2 expression.

R. Jove, S. Moon, M. Behlke, 2008, Biochemical and biophysical research communications.

AG 490 inhibits G 1S traverse in BALB / c-3 T 3 cells following either mitogenic stimulation or exogenous expression of E 2 F-1

R. Jove, P. Moseley, Yihong Ma, 2004 .

Molecular dynamics simulations of the conformational changes in signal transducers and activators of transcription, Stat1 and Stat3.

Yate-Ching Yuan, R. Jove, N. Vaidehi, 2009, Journal of molecular graphics & modelling.

Modification of insulin-like growth factor 1 receptor, c-Src, and Bcl-XL protein expression during the progression of Barrett's neoplasia.

D. Coppola, J. Cheng, R. Jove, 2003, Human pathology.

A simple method to improve probe set estimates from oligonucleotide arrays.

Shrikant Mane, S. Mane, R. Jove, 2002, Mathematical biosciences.

Activated Signal Transducers and Activators of Transcription 3 Signaling Induces CD46 Expression and Protects Human Cancer Cells from Complement-Dependent Cytotoxicity

Hua Yu, R. Jove, Meijuan Huang, 2007, Molecular Cancer Research.

Reconstitution of interactions between the Src tyrosine kinases and Ras GTPase-activating protein using a baculovirus expression system.

R. Jove, M. Marshall, J. Gibbs, 1992, The Journal of biological chemistry.

Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase.

R. Jove, S. Burakoff, C. Yu, 1997, Journal of immunology.

MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage

A. Bild, R. Jove, Meijuan Huang, 2002, Oncogene.

cells sensitive and resistant to STI-571 in association with down-regulation of Bcr- Abl, abrogation of STAT5 activity, and Bax conformational change.

R. Jove, Meijuan Huang, P. Dent, 2004 .

Lack of induction of neuroretinal cell proliferation by Rous sarcoma virus variants that carry the c-src gene

H. Iba, R. Jove, H. Hanafusa, 1985, Molecular and cellular biology.

Synergistic anti-tumor effect of combined inhibition of EGFR and JAK/STAT3 pathways in human ovarian cancer

R. Jove, J. Yim, Jun Wu, 2015, Molecular Cancer.

Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis

Hua Yu, R. Jove, Fan Yang, 2012, Cancer biology & therapy.

Tyrosine phosphorylation of Ras GTPase-activating protein stabilizes its association with p62 at membranes of v-Src transformed cells.

R. Jove, S. Park, 1993, The Journal of biological chemistry.

Constitutive Activation of JAK1 in Src-transformed Cells*

R. Jove, C. Carter-Su, Chao-Lan Yu, 1997, The Journal of Biological Chemistry.

Inhibition of STAT3 activity with STAT3 antisense oligonucleotide (STAT3-ASO) enhances radiation-induced apoptosis in DU145 prostate cancer cells

R. Jove, J. Torres-Roca, M. Sekharam, 2003 .

Signal Transducers and Activators of Transcription: Novel Targets for Anticancer Therapeutics.

Hua Yu, R. Jove, W. Dalton, 1999, Cancer control : journal of the Moffitt Cancer Center.

Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells.

J. Turkson, R. Jove, A. Hamilton, 2006, Cancer letters.

N-terminal Sequences Contained in the Src Homology 2 and 3 Domains of p120 GTPase-activating Protein Are Required for Full Catalytic Activity Toward Ras (*)

R. Jove, M. Marshall, Wenyan Miao, 1996, The Journal of Biological Chemistry.

STAT3 inhibitor having anti-cancer activity and methods (US)

J. Turkson, R. Jove, S. Sebti, 2020 .