A. Simeone

A. Simeone, D. Acampora, P. Andrews, 1991, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Nucleic Acids Research

M. D'Esposito, A. Simeone, E. Boncinelli, 2008, Nucleic Acids Research.

CLONAL SELECTION AND MOLECULAR CHARACTERISATION BY RAPD ANALYSIS OF THE FIG (FICUS CARICA L.) "DOTTATO" AND "BIANCO DEL CILENTO" CULTIVARS IN ITALY

A. Simeone, U. Galderisi, G. Grassi, 2003 .

A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo

Wolfgang Wurst, Lori Sussel, Nilima Prakash, 2006, Development.

High level expression of the HMGI (Y) gene during embryonic development.

A. Simeone, G. Chiappetta, M. Santoro, 1996, Oncogene.

Otx2 Regulates Subtype Specification and Neurogenesis in the Midbrain

M. Koch, R. Kageyama, A. Simeone, 2005, The Journal of Neuroscience.

Uncoupling of Grb2 from the Met Receptor In Vivo Reveals Complex Roles in Muscle Development

A. Simeone, R. Klein, P. Comoglio, 1996, Cell.

Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development.

M. D'Esposito, A. Simeone, D. Acampora, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Developmental genetic evidence for a monophyletic origin of the bilaterian brain.

A. Simeone, H. Reichert, 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

A human homoeo box gene specifically expressed in spinal cord during embryonic development

C. Peschle, A. Simeone, E. Boncinelli, 1986, Nature.

Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms.

M Alcalay, A. Simeone, D. Acampora, 1992, Oncogene.

Cloning of the human interferon-related developmental regulator (IFRD1) gene coding for the PC4 protein, a member of a novel family of developmentally regulated genes.

A. Simeone, D. Guardavaccaro, F. Tirone, 1998, Genomics.

Reorganization of enhancer patterns in transition from naive to primed pluripotency.

A. Simeone, D. Acampora, Zhixiang Wu, 2014, Cell stem cell.

Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast.

A. Simeone, D. Acampora, Daniela Omodei, 2016, Cell reports.

Differential and stage-related expression in embryonic tissues of a new human homoeobox gene

C. Peschle, A. Simeone, D. Acampora, 1986, Nature.

Dickkopf 3 Promotes the Differentiation of a Rostrolateral Midbrain Dopaminergic Neuronal Subset In Vivo and from Pluripotent Stem Cells In Vitro in the Mouse

C. Niehrs, W. Wurst, A. Simeone, 2015, The Journal of Neuroscience.

Otx2 Controls Identity and Fate of Glutamatergic Progenitors of the Thalamus by Repressing GABAergic Differentiation

A. Simeone, E. Puelles, D. Acampora, 2006, The Journal of Neuroscience.

Altered dopaminergic innervation and amphetamine response in adult Otx2 conditional mutant mice

G. Fisone, W. Wurst, A. Simeone, 2006, Molecular and Cellular Neuroscience.

The caudal limit of Otx2 gene expression as a marker of the midbrain/hindbrain boundary: a study using in situ hybridisation and chick/quail homotopic grafts.

A. Simeone, S. Millet, E. Bloch-Gallego, 1996, Development.

The H3K27 demethylase JMJD3 is required for maintenance of the embryonic respiratory neuronal network, neonatal breathing, and survival.

G. Natoli, A. Simeone, B. Tusi, 2012, Cell reports.

Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis

T. Hoang, A. Simeone, D. Acampora, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Nested expression domains of four homeobox genes in developing rostral brain

M. Gulisano, A. Simeone, D. Acampora, 1992, Nature.

Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells

A. Simeone, D. Acampora, P. Andrews, 1990, Nature.

Conserved usage of gap and homeotic genes in patterning the CNS

A. Simeone, H. Reichert, 1999, Current Opinion in Neurobiology.

Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila.

A. Simeone, D. Acampora, D. Gerlich, 1998, Development.

Folic acid prevents exencephaly in Cited2 deficient mice.

A. Simeone, N. Greene, R. Beddington, 2002, Human molecular genetics.

Identification of sixteen novel candidate genes for late onset Parkinson’s disease

Sonja W. Scholz, Miguel Ángel Martínez, D. Hernandez, 2021, Molecular Neurodegeneration.

Otx2 selectively controls the neurogenesis of specific neuronal subtypes of the ventral tegmental area and compensates En1-dependent neuronal loss and MPTP vulnerability.

W. Wurst, A. Simeone, D. Acampora, 2013, Developmental biology.

Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP

W. Wurst, A. Simeone, D. Acampora, 2010, Nature Neuroscience.

Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon

W. Wurst, A. Simeone, D. Acampora, 2008, Development.

Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants

A. Simeone, D. Acampora, L. Bally-Cuif, 2006, Development.

Otx2 restricts entry to the mouse germline

A. Simeone, D. Acampora, Man Zhang, 2018, Nature.

Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex.

M. Gulisano, A. Simeone, D. Acampora, 1992, The EMBO journal.

Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.

M. D'Esposito, A. Carè, A. Simeone, 1989, Differentiation; research in biological diversity.

Activation of four homeobox gene clusters in human embryonal carcinoma cells induced to differentiate by retinoic acid.

A. Simeone, P. Andrews, E. Boncinelli, 1988, Differentiation; research in biological diversity.

Loss of Glutamatergic Pyramidal Neurons in Frontal and Temporal Cortex Resulting from Attenuation of Fgfr1 Signaling Is Associated with Spontaneous Hyperactivity in Mice

JaneR . Taylor, A. Simeone, F. Vaccarino, 2022 .

The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues.

A. Simeone, D. Acampora, P. Comoglio, 1995, Oncogene.

TTF‐2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation

M. Arnone, A. Simeone, B. Taylor, 1997, The EMBO journal.

The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord

Michael Brand, Hamid Meziane, Mohammed Selloum, 2013, PeerJ.

The role of Otx2 in organizing the anterior patterning in mouse.

A. Simeone, D. Acampora, 2001, The International journal of developmental biology.

Sequential activation of human HOX2 homeobox genes by retinoic acid in embryonal carcinoma cells.

A. Simeone, D. Acampora, P. Andrews, 1990 .

Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cells

M. D'Esposito, A. Simeone, D. Acampora, 1991, Mechanisms of Development.

Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors

M. T. Pascarelli, C. Babiloni, C. Limatola, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Bmp5/7 in concert with the mid-hindbrain organizer control development of noradrenergic locus coeruleus neurons

A. Simeone, M. Krauthammer, I. Meir, 2010, Molecular and Cellular Neuroscience.

Retinoic acid induces stage-specific antero-posterior transformation of rostral central nervous system

A. Simeone, D. Acampora, C. Arra, 1995, Mechanisms of Development.

Orthopedia, a novel homeobox-containing gene expressed in the developing CNS of both mouse and drosophila

A. Simeone, D. Acampora, J. Casanova, 1994, Neuron.

Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5.

G. Merlo, A. Simeone, D. Acampora, 1999, Development.

A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo.

A. Simeone, D. Acampora, E. Boncinelli, 1993, The EMBO journal.

Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3.

A. Simeone, M. Santoro, A. Fusco, 1998, Genomics.

Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain

W. Wurst, A. Simeone, E. Puelles, 2003, Nature Neuroscience.

Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes.

A. Simeone, D. Acampora, F. Tuorto, 1999, Development.

Transient dwarfism and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control of pituitary levels of GH, FSH and LH.

P. Macchia, P. Brûlet, A. Simeone, 1998, Development.

Epilepsy and brain abnormalities in mice lacking the Otx1 gene

P. Brûlet, A. Simeone, D. Acampora, 1996, Nature Genetics.

Otx genes in brain morphogenesis

M. Gulisano, A. Simeone, D. Acampora, 2001, Progress in Neurobiology.

A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei

A. Simeone, J. A. Carlos, L. G. D. Giovannantonio, 2010, Nature Neuroscience.

Fibroblast growth factor 2 increases Otx2 expression in precursor cells from mammalian telencephalon

A. Simeone, L. Robel, M. Ding, 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

At least three human homeoboxes on chromosome 12 belong to the same transcription unit.

M. D'Esposito, A. Simeone, D. Acampora, 1988, Nucleic acids research.

Role of Otx transcription factors in brain development

A. Simeone, E. Puelles, D. Acampora, 2003 .

Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition

A. Simeone, D. Acampora, L. D. Di Giovannantonio, 2013, Development.

Cellular Heterogeneity During Embryonic Stem Cell Differentiation to Epiblast Stem Cells is Revealed by the ShcD/RaLP Adaptor Protein

D. Constam, A. Simeone, A. Sciullo, 2012, Stem cells.

Cloning and characterization of two members of the vertebrate Dlx gene family.

M. D'Esposito, M. Gulisano, A. Simeone, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Evolutionary conservation of otd/Otx2 transcription factor action: a genome-wide microarray analysis in Drosophila

Michael Primig, Martin Strahm, Ulrich Certa, 2002, Genome Biology.

Developmental rescue of Drosophila cephalic defects by the human Otx genes.

A. Simeone, D. Acampora, H. Reichert, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR.

A. Simeone, D. Acampora, A. Annino, 2001, Development.

Otx genes in evolution: are they involved in instructing the vertebrate brain morphology?

A. Simeone, D. Acampora, A. Annino, 2001, Journal of anatomy.

Otx1 and Otx2 in the development and evolution of the mammalian brain

A. Simeone, 1998, The EMBO journal.

Isolation and mapping of EVX1, a human homeobox gene homologous to even-skipped, localized at the 5' end of HOX1 locus on chromosome 7.

M. D'Esposito, M. Gulisano, A. Simeone, 1991, Nucleic acids research.

EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2.

M. D'Esposito, A. Simeone, D. Acampora, 1991, Genomics.

Expression of HOX homeogenes in human neuroblastoma cell culture lines.

M. D'Esposito, A. Simeone, D. Acampora, 1990, Differentiation; research in biological diversity.

Human HOX genes are differentially activated by retinoic acid in embryonal carcinoma cells according to their position within the four loci.

M. D'Esposito, A. Simeone, D. Acampora, 1990, Cell differentiation and development : the official journal of the International Society of Developmental Biologists.

The three most downstream genes of the Hox-3 cluster are expressed in human extraembryonic tissues including trophoblast of androgenetic origin.

A. Simeone, C. Meijer, E. Boncinelli, 1990, Development.

FGF/FGFR2 Signaling Regulates the Generation and Correct Positioning of Bergmann Glia Cells in the Developing Mouse Cerebellum

W. Wurst, A. Simeone, S. Hölter, 2014, PloS one.

Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation.

A. Simeone, D. Acampora, F. Tuorto, 1998, Development.

The transcription factor Otx2 regulates choroid plexus development and function

Magdalena Götz, Johannes Beckers, A. Simeone, 2013, Development.

Identification and characterization of novel human endogenous retroviral sequences prefentially expressed in undifferentiated embryonal carcinoma cells.

A. Simeone, A. Di Cristofano, L. Lania, 1991, Nucleic acids research.

Dentate gyrus formation requires Emx2.

P Gruss, A. Simeone, P. Gruss, 1996, Development.

Embryonic expression pattern of the murine figf gene, a growth factor belonging to platelet-derived growth factor/vascular endothelial growth factor family

Salvatore Oliviero, A. Simeone, D. Acampora, 1998, Mechanisms of Development.

Otx1 null mutant mice show partial segregation of sensory epithelia comparable to lamprey ears

Bernd Fritzsch, Massimo Signore, A. Simeone, 2001, Development Genes and Evolution.

Patterning of the mammalian cochlea.

A. Simeone, D. Acampora, R. Cantos, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Human homoeobox-containing genes in development.

M. D'Esposito, A. Simeone, D. Acampora, 1987, Human reproduction.

Human cDNA clones containing homeo box sequences.

A. Simeone, D. Acampora, E. Boncinelli, 1985, Cold Spring Harbor symposia on quantitative biology.

Expression of the brain transcription factor OTX1 occurs in a subset of normal germinal-center B cells and in aggressive Non-Hodgkin Lymphoma.

A. Simeone, D. Acampora, S. Casola, 2009, The American journal of pathology.

OtxGenes and the Genetic Control of Brain Morphogenesis

M. Gulisano, A. Simeone, D. Acampora, 1999, Molecular and Cellular Neuroscience.

Otx1 and Otx2 activities are required for the normal development of the mouse inner ear.

A. Simeone, F. Tuorto, A Simeone, 1999, Development.

The TINS Lecture Understanding the roles of Otx1 and Otx2 in the control of brain morphogenesis

A. Simeone, D. Acampora, Dario Acampora, 1999, Trends in Neurosciences.

Otx 1 and Otx 2 activities are required for the normal development of the mouse inner ear

A. Simeone, F. Tuorto, Doris K. Wu, 2022 .

Otx genes in corticogenesis and brain development.

A. Simeone, D. Acampora, P. Barone, 1999, Cerebral cortex.

The role of Otx and Otp genes in brain development.

A. Simeone, D. Acampora, M. Di Bonito, 2000, The International journal of developmental biology.

Functional Antagonism between OTX2 and NANOG Specifies a Spectrum of Heterogeneous Identities in Embryonic Stem Cells

A. Simeone, D. Acampora, I. Chambers, 2017, Stem cell reports.

OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm.

A. Simeone, E. Puelles, D. Acampora, 2003, Gene expression patterns : GEP.

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain

W. Wurst, A. Simeone, E. Puelles, 2009, Development.

Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain

Wolfgang Wurst, Francesca Tuorto, Alessandro Usiello, 2004, Development.

Developmental expression of the RET protooncogene.

A. Simeone, M. Santoro, A. Fusco, 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Sequence organization of the ribosomal spacer of D.melanogaster.

A. Simeone, E. Boncinelli, A. de Falco, 1982, Nucleic acids research.

Orthopedia Homeodomain Protein Is Essential for Diencephalic Dopaminergic Neuron Development

S. Ryu, W. Driever, A. Simeone, 2007, Current Biology.

Genetic and molecular roles of Otx homeodomain proteins in head development.

M. Gulisano, A. Simeone, D. Acampora, 2000, Gene.

Genetic control of brain morphogenesis through Otx gene dosage requirement.

A. Simeone, D. Acampora, F. Tuorto, 1997, Development.

Otx genes in neurogenesis of mesencephalic dopaminergic neurons

A. Simeone, E. Puelles, D. Acampora, 2011, Developmental neurobiology.

The role of Otx genes in progenitor domains of ventral midbrain.

A. Simeone, E. Puelles, D. Acampora, 2009, Advances in experimental medicine and biology.

Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border

A. Simeone, P. Gruss, P. Collombat, 2006, Development.

Positioning the isthmic organizer where Otx2 and Gbx2meet.

A. Simeone, A Simeone, Antonio Simeone, 2000, Trends in genetics : TIG.

Location and Size of Dopaminergic and Serotonergic Cell Populations Are Controlled by the Position of the Midbrain–Hindbrain Organizer

Matthias Oesterheld, Wolfgang Wurst, Massimo Signore, 2003, The Journal of Neuroscience.

The upstream region of the human homeobox gene HOX3D is a target for regulation by retinoic acid and HOX homeoproteins.

A. Simeone, E. Boncinelli, F. Mavilio, 1992, The EMBO journal.

The Role of Otx2 in Adult Mesencephalic–Diencephalic Dopaminergic Neurons

A. Simeone, D. Acampora, C. Tomasetti, 2011, Molecular Neurobiology.

Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity

W. Wurst, A. Simeone, D. Acampora, 2014, Development.

The Transcription Factor Orthodenticle Homeobox 2 Influences Axonal Projections and Vulnerability of Midbrain Dopaminergic Neurons.

E. Martin, J. Vance, A. Simeone, 2010 .

Graded Otx2 activities demonstrate dose-sensitive eye and retina phenotypes.

A. Prochiantz, A. Simeone, D. Acampora, 2014, Human molecular genetics.

Common and Rare Variants in TMEM175 Gene Concur to the Pathogenesis of Parkinson’s Disease in Italian Patients

C. Webber, T. Esposito, A. Simeone, 2023, Molecular Neurobiology.

Expression pattern of two otx genes suggests a role in specifying anterior body structures in zebrafish.

A. Simeone, E. Boncinelli, P. Mercier, 1995, The International journal of developmental biology.

Establishment of stable iPS-derived human neural stem cell lines suitable for cell therapies

A. Simeone, M. Copetti, T. Mazza, 2018, Cell Death & Disease.

Morphological organization of somatosensory cortex in Otx1−/− mice

G. Avanzini, A. Simeone, D. Acampora, 2002, Neuroscience.

Xrxl, a novel Xenopus homeobox gene expressed during eye and pineal gland development

A. Simeone, S. Casarosa, M. Andreazzoli, 1997, Mechanisms of Development.

Isolation and expression of the homeobox gene Gbx1 during mouse development

A. Simeone, M. Rhinn, M. Brand, 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

Chromosome locations of human EMX and OTX genes.

A. Simeone, D. Acampora, K. Huebner, 1994, Genomics.

Genetic mapping of the homeobox-containing gene Otxl gene on mouse Chromosome 11

A. Simeone, T. Dragani, G. Manenti, 1996, Mammalian Genome.

'… and C is for Clioquinol' - the AβCs of Alzheimer's disease

A. Simeone, 2002 .

Serotonin Hyperinnervation Abolishes Seizure Susceptibility in Otx2 Conditional Mutant Mice

W. Wurst, A. Simeone, Y. Bozzi, 2008, The Journal of Neuroscience.

Genetic control of dopaminergic neuron differentiation

A. Simeone, 2005, Trends in Neurosciences.

Orthopedia Homeodomain Protein Is Essential for Diencephalic Dopaminergic Neuron Development

S. Ryu, W. Driever, A. Simeone, 2008, Current Biology.

Direct repression of Nanog and Oct4 by OTX2 modulates the contribution of epiblast-derived cells to germline and somatic lineage.

A. Simeone, D. Acampora, I. Chambers, 2021, Development.

Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues.

A. Simeone, A. Pizzuti, R. Taramelli, 1998, Genomics.

3895 Dentate gyrus formation requires Emx 2

A. Simeone, P. Gruss, E. Boncinelli, 1996 .

Biobased Nanographene Oxide Creates Stronger Chitosan Hydrogels with Improved Adsorption Capacity for Trace Pharmaceuticals

A. Simeone, M. Hakkarainen, Karin Odelius, 2017 .

Developmental Expression of the RET Protooncogene 1

A. Simeone, M. Santoro, N. Dathan, 2005 .

Human HOX homeobox genes.

A. Simeone, D. Acampora, E. Boncinelli, 1991, Oxford surveys on eukaryotic genes.

Synaptic Properties of Neocortical Neurons in Epileptic Mice Lacking the Otx1 Gene

G. Avanzini, A. Simeone, D. Acampora, 2000, Epilepsia.

Reorganization of enhancer patterns in transition from naive to primed pluripotency.

A. Simeone, D. Acampora, Zhixiang Wu, 2014, Cell stem cell.

Loss of Glutamatergic Pyramidal Neurons in Frontal and Temporal Cortex Resulting from Attenuation of FGFR1 Signaling Is Associated with Spontaneous Hyperactivity in Mice

JaneR . Taylor, A. Simeone, F. Vaccarino, 2004, The Journal of Neuroscience.

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain

W. Wurst, A. Simeone, E. Puelles, 2009, Development.

Retinoic acid induces stage-specific repatterning of the rostral central nervous system.

A. Simeone, D. Acampora, F. Tuorto, 1996, Developmental biology.

The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons.

E. Martin, J. Vance, A. Simeone, 2010, Brain : a journal of neurology.

Immunoprecipitation and mass spectrometry identify non-cell autonomous Otx2 homeoprotein in the granular and supragranular layers of mouse visual cortex

A. Prochiantz, A. Simeone, D. Acampora, 2014, F1000Research.

Embryonic defects and growth alteration in mice with homozygous disruption of the Patz1 gene

A. Simeone, P. Chieffi, A. Fusco, 2013, Journal of cellular physiology.