R. Karr

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Single amino acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition.

J. Sidney, H. Grey, J. Krieger, 1991, Journal of immunology.

Characterization of a conserved T cell epitope in HIV-1 gp41 recognized by vaccine-induced human cytolytic T cells.

R. Siliciano, R. Karr, S. Koenig, 1991, Journal of immunology.

Mice Deficient in IL-I~ Manifest Impaired Contact Hypersensitivity to Trinitrochlorobenzene

R. Karr, D. Chaplin, J. Goellner, 1996 .

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.

R. Karr, J. Bluestone, D. Loh, 1995, Journal of immunology.

Heterogeneous MHC II restriction pattern of autoreactive desmoglein 3 specific T cell responses in pemphigus vulgaris patients and normals.

R. Karr, M. Amagai, M. Hertl, 1998, The Journal of investigative dermatology.

Structural identity of human histocompatibility leukocyte antigen-B27 molecules from patients with ankylosing spondylitis and normal individuals.

R. Karr, B. Schwartz, Y. Hahn, 1982, The Journal of clinical investigation.

Association of HLA-DRw4 with rheumatoid arthritis in black and white patients.

R. Karr, B. Schwartz, G. Rodey, 1980, Arthritis and rheumatism.

Functional activity of staphylococcal enterotoxin A requires interactions with both the alpha and beta chains of HLA-DR.

R. Karr, D. Karp, J. Dowd, 1996, Molecular immunology.

Recombination sites in the HLA class II region are haplotype dependent.

P. Gregersen, J. Silver, R. Karr, 1988, Journal of immunology.

Gamma interferon and 5-azacytidine cause transcriptional elevation of class I major histocompatibility complex gene expression in K562 leukemia cells in the absence of differentiation

R. Karr, T. Gonwa, Emily Chen, 1986, Molecular and cellular biology.

Effect of isotypes and allelic polymorphism on the binding of staphylococcal exotoxins to MHC class II molecules.

R. Karr, J. Trowsdale, R. Geha, 1990, Journal of immunology.

An HLA-DR5 homozygous cell line expresses two DS (I-A-like) molecules

J. Silver, R. Karr, S. Goyert, 1983, The Journal of experimental medicine.

Analysis of the molecular specificities of anti-class II monoclonal antibodies by using L cell transfectants expressing HLA class II molecules.

P. Gregersen, J. Silver, R. Karr, 1988, Journal of immunology.

DRw11 haplotypes: continuum of DRB1 diversity augmented by unique DQ/DRw52 associations.

R. Karr, W. Yu, C. Hurley, 1991, Human immunology.

Analysis of DR beta and DQ beta chain cDNA clones from a DR7 haplotype.

P. Gregersen, J. Silver, R. Karr, 1986, Journal of immunology.

Cells homozygous for two HLA-DR7-associated HLA-D specificities express highly similar DR molecules but different DQ molecules.

R. Karr, W. Bias, S. H. Hsu, 1986, Human immunology.

Immunochemical analysis of class II molecules expressed by a human B cell line with the unusual class II genotype, DR5+, MB1+, (MB3-), MT2+.

R. Karr, H. Festenstein, J. Sachs, 2008, Tissue antigens.

The molecular specificities of DS-specific reagents: an MB3-like monoclonal antibody isolates two DS molecules.

R. Karr, 1985, Human immunology.

The MT4 Allodeterminant Is Borne on an HLA‐DS Molecule on DR5 Cells

J. Silver, R. Karr, S. Goyert, 1984, Scandinavian journal of immunology.

Molecular relationships of the human B cell alloantigens, MT2, MB3, MT4, and DR5.

R. Karr, D. Mann, B. Schwartz, 1982, Journal of immunology.

Identification of cross-reactive T cell restriction epitopes located on the DR7β1 and DRβ4 molecules

R. Karr, P. Debré, G. Bismuth, 1990 .

HPRT mutant T-cell lines from multiple sclerosis patients recognize myelin proteolipid protein peptides

R. Karr, A. Cross, H. McFarland, 1997, Journal of Neuroimmunology.

The role of polymorphic HLA-DR beta chain residues in presentation of viral antigens to T cells

R. Karr, W. Yu, E. Celis, 1990, The Journal of experimental medicine.

Identification of amino acids in HLA-DPw4bβ and -DR5β1 chains that are involved in antibody binding epitodes using site-directed mutagenesis and DNA-mediated gene transfer

R. Karr, R. Watts, Wei-yuan Yu, 1990 .

Negative and positive regulation of human leukocyte antigen class I gene transcription in K562 leukemia cells

R. Karr, E. Chen, G. Ginder, 1987, Molecular and cellular biology.

Negative andPositive Regulation ofHumanLeukocyte Antigen ClassIGeneTranscription inK562LeukemiaCells

R. Karr, Emily Chen, 1987 .

Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation.

R. Karr, A. Cross, T. Girard, 1995, The Journal of clinical investigation.

A newly characterized HLA-DP beta-chain allele. Evidence for DP beta heterogeneity within the DPw4 specificity.

R. Karr, W. Yu, C. Alber, 1988, Journal of immunology.

Demonstration of a third structurally distinct human Ia beta chain by two-dimensional gel electrophoresis

R. Karr, D. Mann, B. Schwartz, 1982, The Journal of experimental medicine.

Diverse locations of amino acids in HLA-DRβ chains involved in polymorphic antibody binding epitopes on DR(α,β1∗0101), DR(α,β1∗1101), and DR(α,β3∗0202) molecules

G. Ferrara, M. Pistillo, R. Karr, 1992 .

Functional analysis of MHC class II-restricted T cells derived from a Caucasian with a DR4, Dw15, DQw8 haplotype.

P. Gregersen, R. Karr, E. Celis, 1990, Human immunology.

Presentation of an immunodominant T-cell epitope of hepatitis B surface antigen by the HLA-DPw4 molecule

R. Karr, E. Celis, Esteban CELISlt, 1989, Journal of virology.

Antibodies directed against HLA-DR gene products exhibit the CYNAP phenomenon.

R. Karr, H. Gebel, T. Fuller, 2008, Tissue antigens.

Alloantisera and Monoclonal Antibodies Which Appear to Define the Same Ia Allospecificity in Population Studies Do Not Detect the Same Ia Molecules in Biochemical Studies

R. Karr, 1984 .

Three Distinct Human Ia Molecules Isolated from a DR5 Homozygous Lymphoblastoid Cell Line

R. Karr, B. Schwartz, C. C. Kannapell, 1983 .

CTLA-4-Fc treatment of ongoing EAE improves recovery, but has no effect upon relapse rate. Implications for the mechanisms involved in disease perpetuation

R. Karr, A. Cross, M. San, 1999, Journal of Neuroimmunology.

Differential effects of CTLA-4 substitutions on the binding of human CD80 (B7-1) and CD86 (B7-2).

R. Karr, J. Shieh, C. Leysath, 1996, Journal of immunology.

All human monocytes have the capability of expressing HLA-DQ and HLA-DP molecules upon stimulation with interferon-gamma.

R. Karr, T. Gonwa, J. Frost, 1986, Journal of immunology.

Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig.

R. Karr, B. Schwartz, L. Mengle-Gaw, 1995, The Journal of clinical investigation.

Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris.

R. Karr, J. Strominger, K. Wucherpfennig, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2.

R. Karr, D. Chaplin, V. Holers, 1996, Proceedings of the National Academy of Sciences of the United States of America.

A repetitive sequence of Epstein-Barr virus nuclear antigen 6 comprises overlapping T cell epitopes which induce HLA-DR-restricted CD4(+) T lymphocytes.

R. Karr, I. Ernberg, I. Simon, 2000, International immunology.

The HLA Complex

R. Karr, 1998 .

Substitutions in the HLA-DR alpha chain differentially affect DR7-restricted T-cell recognition of rabies virus antigen.

R. Karr, E. Celis, T. Saibara, 1996, Human immunology.

Negatively charged residues interacting with the p4 pocket confer binding specificity to DRB1*0401.

R. Karr, D. Kirschmann, T. Baudino, 1995, Arthritis and rheumatism.

HLA-DR residues accessible under the peptide-binding groove contribute to polymorphic antibody epitopes.

R. Karr, W. Marshall, S. Drover, 1995, Human immunology.

Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association

R. Karr, J. Guenot, Z. Nagy, 1995, The Journal of experimental medicine.

Pocket 4 of the HLA-DR(alpha,beta 1*0401) molecule is a major determinant of T cells recognition of peptide

A. Sette, R. Karr, F. Sinigaglia, 1995, The Journal of experimental medicine.

T cell receptor and peptide‐contacting residues in the HLA‐DR17(3) β1 chain

R. Karr, T. Ottenhoff, A. Geluk, 1994 .

Recombination between DQ alpha and DQ beta genes generates human histocompatibility leukocyte antigen class II haplotype diversity.

P. Gregersen, J. Silver, R. Karr, 1987, Journal of immunology.

Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone

R. Karr, D. Chaplin, J. Goellner, 1996, The Journal of experimental medicine.

Polymorphism of HLA-DR beta chains in DR4, -7, and -9 haplotypes: implications for the mechanisms of allelic variation.

P. Gregersen, J. Silver, R. Winchester, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Ia molecular localization of the DRw52 allodeterminant and the DRw52-like determinants defined by monoclonal antibodies.

R. Karr, F. Koning, C. Alber, 1985, Journal of immunology.

HLA-DR beta chain residues that are predicted to be located in the floor of the peptide-binding groove contribute to antibody-binding epitopes.

R. Karr, R W Karr, E Klohe, 1993, Human immunology.

Critical role of HLA-DR beta 1 residue 58 in multiple polymorphic epitopes recognized by xenogeneic and allogeneic antibodies.

G. Ferrara, M. Pistillo, R. Karr, 1992, Human immunology.

Molecular analysis of the immune response to human cytomegalovirus glycoprotein B. I. Mapping of HLA-restricted helper T cell epitopes on gp93.

R. Karr, F. Bach, P. Donahue, 1993, The Journal of general virology.

Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: Effect of HIV sequence variation and a mechanism for CD4+ cell depletion

R. Siliciano, E. Reinherz, R. Karr, 1988, Cell.

Genetic restriction and fine specificity of human T cell clones reactive with rabies virus.

R. Karr, E. Celis, H. Koprowski, 1988, Journal of immunology.

Antigen-specific T cells with monogamous or promiscuous restriction patterns are sensitive to different HLA-DR beta chain substitutions.

R. Karr, W. Yu, A. Lanzavecchia, 1991, Journal of immunology.

HLA-DRB1 and -DRB4 genes are differentially regulated at the transcriptional level.

R. Karr, L. Stunz, R. Anderson, 1989, Journal of immunology.

Amino Acids in the Peptide‐Binding Groove Influence an Antibody‐Defined, Disease‐Associated HLA‐DR Epitope

R. Karr, G. Nepom, W. Kwok, 1994, Scandinavian journal of immunology.

Polymorphic HLA-DR7 beta 1 chain residues that are involved in T cell allorecognition.

R. Karr, W. Yu, S. Rosen‐Bronson, 1991, Journal of immunology.

Identification of residues involved in polymorphic antibody binding epitopes on HLA-DR molecules.

R. Karr, W. Yu, J. Johnson, 1992, Human immunology.

HLA-DR alpha chain residues located on the outer loops are involved in nonpolymorphic and polymorphic antibody-binding epitopes.

R. Karr, X. Fu, 1994, Human immunology.

Analysis of monoclonal antibodies specific for unique and shared determinants on HLA-DR4 molecules.

R. Karr, W. Marshall, S. Drover, 1994, Human immunology.

T lymphocytes from healthy individuals with specificity to self-epitopes shared by the mycobacterial and human 65-kilodalton heat shock protein.

R. Young, R. Karr, S. Kaufmann, 1989, Journal of immunology.

Development of AO-176, a Next-Generation Humanized Anti-CD47 Antibody with Novel Anticancer Properties and Negligible Red Blood Cell Binding

R. Karr, Benjamin J. Capoccia, M. Bouchlaka, 2019, Molecular Cancer Therapeutics.

P3-112: Initial phase 1 results of gemcitabine, carboplatin and IMO-2055, a toll like receptor 9 (TLR9) agonist, in patients (pts) with advanced solid tumors

R. Karr, J. Marshall, S. Malik, 2007 .

Different regions of the N-terminal domains of HLA-DR1 influence recognition of individual peptide-DR1 complexes.

R. R. Olson, R. Karr, R. Lechler, 1994, Human immunology.

MHC-antigen-T cell interactions: an overview.

H. Grey, A. Sette, J. Krieger, 1991, Seminars in immunology.

Structural requirements of peptide and MHC for DR(alpha, beta 1*0401)-restricted T cell antigen recognition.

R. Karr, F. Oftung, T. Shinnick, 1995, Journal of immunology.

Mutations in the third, but not the first or second, hypervariable regions of DR(beta 1*0101) eliminate DR1-restricted recognition of a pertussis toxin peptide.

R. R. Olson, R. Karr, M. D. de Magistris, 1992, Journal of immunology.

Identification of HLA-DR alpha chain residues critical for binding of the toxic shock syndrome toxin superantigen

R. Karr, A. Lanzavecchia, P. Panina-Bordignon, 1992, The Journal of experimental medicine.

Phase 1-2 study of TI-061 alone and in combination with other anti-cancer agents in patients with advanced malignancies.

R. Karr, A. Italiano, A. Bexon, 2017 .

Acidic residues in the DRβ chain third hypervariable region are required for stimulation of a DR(α,β1*0402)-restricted T-cell clone

R. R. Olson, R. Siliciano, R. Karr, 1994 .

HPRT mutant T-cell lines from multiple sclerosis patients recognize myelin proteolipid protein peptides

R. Karr, A. Cross, H. McFarland, 1997, Journal of Neuroimmunology.