M. Churchill

发表

Lipid metabolism in patients infected with Nef-deficient HIV-1 strain.

H. Low, Lesley Cheng, Maria-Silvana Di Yacovo, 2016, Atherosclerosis.

S. Sugden, D. Hazuda, F. Pereyra, 2012, Journal of the International AIDS Society.

Molecular Gymnastics: Mechanisms of HIV-1 Resistance to CCR5 Antagonists and Impact on Virus Phenotypes.

M. Churchill, S. Lewin, J. Flynn, 2015, Current topics in medicinal chemistry.

Differences in coreceptor specificity contribute to alternative tropism of HIV-1 subtype C for CD4+ T-cell subsets, including stem cell memory T-cells

M. Churchill, J. Flynn, P. Gorry, 2014, Retrovirology.

Pathogenesis of macrophage tropic HIV-1.

M. Churchill, P. Gorry, A. Cunningham, 2005, Current HIV research.

Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS

M. Churchill, D. Purcell, S. Wesselingh, 2007, Retrovirology.

Characterization of interactions between transcription factors and a regulatory region spanning nt -320 to -281 of the HIV-1 LTR in T-lymphoid and non-T-lymphoid cells.

M. Churchill, P. Lambert, R. Ramsay, 2002, Journal of biomedical science.

Characterization of Interactions between Transcription Factors and a Regulatory Region Spanning nt –320 to –281 of the HIV-1 LTR in T-Lymphoid and Non-T-Lymphoid Cells

M. Churchill, P. Lambert, R. Ramsay, 2002, Journal of Biomedical Science.

Quantifying Susceptibility of CD4+ Stem Memory T-Cells to Infection by Laboratory Adapted and Clinical HIV-1 Strains

M. Churchill, J. Flynn, P. Gorry, 2014, Viruses.

Frequency and Env determinants of HIV-1 subtype C strains from antiretroviral therapy-naive subjects that display incomplete inhibition by maraviroc

M. Churchill, J. Flynn, P. Gorry, 2016, Retrovirology.

Simplified colorimetric analysis of polymerase chain reactions: detection of HIV sequences in AIDS patients.

M. Churchill, S. Foote, M. G. Peterson, 1990, Gene.

Where does HIV hide? A focus on the central nervous system

M. Churchill, A. Nath, 2013, Current opinion in HIV and AIDS.

CXCR4-Using HIV Strains Predominate in Naive and Central Memory CD4+ T Cells in People Living with HIV on Antiretroviral Therapy: Implications for How Latency Is Established and Maintained

M. Churchill, S. Lewin, Matthew J. Gartner, 2019, Journal of Virology.

Evolution of DC-SIGN use revealed by fitness studies of R5 HIV-1 variants emerging during AIDS progression

M. Churchill, D. Purcell, J. Albert, 2008, Retrovirology.

CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates

M. Churchill, S. Wesselingh, P. Gorry, 2011, Journal of NeuroVirology.

The magnitude of HIV-1 resistance to the CCR5 antagonist maraviroc may impart a differential alteration in HIV-1 tropism for macrophages and T-cell subsets.

M. Churchill, S. Lewin, D. Purcell, 2013, Virology.

Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus

M. Churchill, S. Wesselingh, P. Gorry, 2007, Retrovirology.

Genetic and Functional Analysis of R5X4 Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Derived from Two Individuals Homozygous for the CCR5Δ32 Allele

M. Churchill, D. Purcell, S. Wesselingh, 2006, Journal of Virology.

SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern

M. Churchill, D. Stark, A. Kelleher, 2022, eBioMedicine.

HIV integration and the establishment of latency in CCL19-treated resting CD4+ T cells require activation of NF-κB

M. Churchill, S. Lewin, J. Mak, 2016, Retrovirology.

HIV eradication symposium: will the brain be left behind?

M. Churchill, J. Mankowski, B. Brew, 2015, Journal of NeuroVirology.

Enhanced CD4+ cellular apoptosis by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with progressive HIV-1 infection.

M. Churchill, D. Purcell, N. Saksena, 2010, Virology.

Tissue-Specific Sequence Alterations in the Human Immunodeficiency Virus Type 1 Envelope Favoring CCR5 Usage Contribute to Persistence of Dual-Tropic Virus in the Brain

M. Churchill, D. Purcell, S. Wesselingh, 2009, Journal of Virology.

Strategies to target HIV-1 in the central nervous system

M. Churchill, B. Brew, L. Gray, 2016, Current opinion in HIV and AIDS.

ExVivo Response to Histone Deacetylase (HDAC) Inhibitors of the HIV Long Terminal Repeat (LTR) Derived from HIV-Infected Patients on Antiretroviral Therapy

M. Churchill, S. Lewin, S. Wesselingh, 2014 .

Non-Human Primate Models of HIV Brain Infection and Cognitive Disorders

M. Churchill, K. Busman-Sahay, J. Estes, 2022, Viruses.

c-Myb influences HIV type 1 gene expression and virus production.

M. Churchill, R. Ramsay, N. Deacon, 2001, AIDS research and human retroviruses.

A HIV-Tat/C4-binding protein chimera encoded by a DNA vaccine is highly immunogenic and contains acute EcoHIV infection in mice

M. Churchill, T. Garrod, L. Gray, 2016, Scientific Reports.

HIV reservoirs: what, where and how to target them

R. Siliciano, M. Churchill, R. Swanstrom, 2015, Nature Reviews Microbiology.

HIV-1 Escape from the CCR5 Antagonist Maraviroc Associated with an Altered and Less-Efficient Mechanism of gp120-CCR5 Engagement That Attenuates Macrophage Tropism

M. Churchill, S. Lewin, P. Gorry, 2011, Journal of Virology.

A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations

Brendan L Wilkinson, M. Churchill, S. Lewin, 2013, Retrovirology.

Alternative Coreceptor Requirements for Efficient CCR5- and CXCR4-Mediated HIV-1 Entry into Macrophages

Paul A. Ramsland, M. Churchill, P. Gorry, 2011, Journal of Virology.

The role of oxidative stress in HIV-associated neurocognitive disorders

M. Churchill, J. Estes, Michael Roche, 2021, Brain, behavior, & immunity - health.

Possible clearance of transfusion-acquired nef/LTR-deleted attenuated HIV-1 infection by an elite controller with CCR5 Δ32 heterozygous and HLA-B57 genotype

M. Churchill, D. Cooper, A. Kelleher, 2019, Journal of virus eradication.

CD4-binding site alterations in CCR5-using HIV-1 envelopes influencing gp120-CD4 interactions and fusogenicity.

M. Churchill, S. Wesselingh, P. Gorry, 2011, Virology.

Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo

M. Churchill, S. Lewin, S. Wesselingh, 2007, Retrovirology.

Identification of HIV transmitting CD11c+ human epidermal dendritic cells

Kirstie M. Bertram, M. Churchill, M. Haniffa, 2019, Nature Communications.

Phagocytic Efficiency of Monocytes and Macrophages Obtained From Sydney Blood Bank Cohort Members Infected With an Attenuated Strain of HIV-1

M. Churchill, K. Kedzierska, S. Crowe, 2003, Journal of acquired immune deficiency syndromes.

Mutational analysis of the HIV-1 LTR as a promoter of negative sense transcription

M. Churchill, S. Zeichner, N. Deacon, 2004, Archives of Virology.

Diminished Production of Human Immunodeficiency Virus Type 1 in Astrocytes Results from Inefficient Translation ofgag, env, and nef mRNAs despite Efficient Expression of Tat and Rev

M. Churchill, J. Howard, D. Purcell, 1999, Journal of Virology.

Towards an HIV cure: a global scientific strategy

M. Lederman, J. Mullins, A. Telenti, 2012, Nature Reviews Immunology.

A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter.

M. Churchill, A. Peeters, N. Deacon, 2000, Nucleic acids research.

New Potential Axes of HIV Neuropathogenesis with Relevance to Biomarkers and Treatment.

M. Churchill, B. Brew, T. Angelovich, 2020, Current topics in behavioral neurosciences.

Longitudinal Analysis of Human Immunodeficiency Virus Type 1 nef/Long Terminal Repeat Sequences in a Cohort of Long-Term Survivors Infected from a Single Source

M. Churchill, S. Wesselingh, P. Gorry, 2006, Journal of Virology.

HIV eradication symposium: will the brain be left behind?

M. Churchill, J. Mankowski, B. Brew, 2015, Journal of NeuroVirology.

Macrophage‐tropic HIV‐1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5

M. Churchill, P. Gorry, N. Webb, 2013, Journal of leukocyte biology.

An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes.

M. Churchill, S. Wesselingh, P. Gorry, 2010, Virology.

Viral tropism, fitness and pathogenicity of HIV-1 subtype C

M. Churchill, P. Gorry, M. Jakobsen, 2010 .

Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndrome.

Steven L Wesselingh, Anthony L Cunningham, Lachlan Gray, 2005, Virology.

The role of viral coreceptors and enhanced macrophage tropism in human immunodeficiency virus type 1 disease progression.

M. Churchill, S. Wesselingh, P. Gorry, 2004, Sexual health.

Understanding the mechanisms driving the spread of subtype C HIV-1

M. Churchill, J. Flynn, Matthew J. Gartner, 2020, EBioMedicine.

Persistence of envelopes in different CD4+ T-cell subsets in antiretroviral therapy-suppressed people with HIV

M. Churchill, S. Lewin, J. Flynn, 2022, AIDS.

Ex Vivo Response to Histone Deacetylase (HDAC) Inhibitors of the HIV Long Terminal Repeat (LTR) Derived from HIV-Infected Patients on Antiretroviral Therapy

M. Churchill, S. Lewin, S. Wesselingh, 2014, PloS one.

Structural elements of primary CCR5-using HIV-1 gp120 proteins influencing sensitivity and resistance to the broadly neutralizing monoclonal antibody b12.

M. Churchill, S. Wesselingh, P. Gorry, 2012, Virology.

The Sydney Blood Bank Cohort: implications for viral fitness as a cause of elite control

M. Churchill, J. Zaunders, W. Dyer, 2011, Current opinion in HIV and AIDS.

Transcriptional activity of blood- and cerebrospinal fluid-derived nef/long-terminal repeat sequences isolated from a slow progressor infected with nef-deleted human immunodeficiency virus type 1 (HIV-1) who developed HIV-associated dementia

M. Churchill, D. Purcell, S. Wesselingh, 2006, Journal of NeuroVirology.

Replication-Dependent Pathogenicity of Attenuated nef-Deleted HIV-1 In Vivo

M. Churchill, S. Wesselingh, P. Gorry, 2007, Journal of acquired immune deficiency syndromes.

Phenotype and envelope gene diversity of nef-deleted HIV-1 isolated from long-term survivors infected from a single source

M. Churchill, S. Wesselingh, D. McPhee, 2007, Virology Journal.

Macrophage Tropism and Cytopathicity of HIV-1 Variants Isolated Sequentially from a Long-Term Survivor Infected with nef-Deleted Virus

M. Churchill, S. Wesselingh, D. McPhee, 2007, The open microbiology journal.

Viral Phenotypes and Antibody Responses in Long-Term Survivors Infected with Attenuated Human Immunodeficiency Virus Type 1 Containing Deletions in the nef and Long Terminal Repeat Regions

M. Churchill, S. Wesselingh, D. McPhee, 2007, Journal of Virology.

Longitudinal analysis of nef/long terminal repeat-deleted HIV-1 in blood and cerebrospinal fluid of a long-term survivor who developed HIV-associated dementia.

M. Churchill, S. Wesselingh, B. Brew, 2004, The Journal of infectious diseases.

Extensive astrocyte infection is prominent in human immunodeficiency virus–associated dementia

M. Churchill, S. Wesselingh, B. Brew, 2009, Annals of neurology.

Astrocyte specific viral strains in HIV dementia

M. Churchill, S. Wesselingh, P. Gorry, 2004, Annals of neurology.

HIV-1 transcriptional regulation in the central nervous system and implications for HIV cure research

M. Churchill, S. Wesselingh, P. Gorry, 2014, Journal of NeuroVirology.

Primary HIV-1 R5 isolates from end-stage disease display enhanced viral fitness in parallel with increased gp120 net charge.

M. Churchill, D. Purcell, J. Albert, 2008, Virology.

Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues

M. Churchill, D. Purcell, S. Wesselingh, 2006, Journal of NeuroVirology.

Longitudinal analysis of subtype C envelope tropism for memory CD4+ T cell subsets over the first 3 years of untreated HIV-1 infection

M. Churchill, S. Lewin, P. Moore, 2020, Retrovirology.

Intact HIV Proviruses Persist in the Brain Despite Viral Suppression with ART

M. Churchill, S. Lewin, B. Brew, 2022, Annals of neurology.

HIV-1 Entry and Trans-Infection of Astrocytes Involves CD81 Vesicles

M. Churchill, S. Wesselingh, P. Gorry, 2014, PloS one.

HIV latency can be established in proliferating and nonproliferating resting CD4+ T cells in vitro: implications for latency reversal

Suha M. Saleh, M. Churchill, S. Lewin, 2019, AIDS.

HDAC inhibitors in HIV

M. Churchill, S. Lewin, P. Ellenberg, 2012, Immunology and cell biology.

HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production.

Heather Donaghy, Helen Cumming, Michael Gale, 2011, Blood.

Is the central nervous system a reservoir of HIV-1?

M. Churchill, S. Wesselingh, J. Flynn, 2014, Current opinion in HIV and AIDS.

CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency-reversing agents with implications for cure strategies

M. Churchill, S. Lewin, S. Wesselingh, 2015, Molecular Psychiatry.

Modular Lentiviral Vectors for Highly Efficient Transgene Expression in Resting Immune Cells

M. Churchill, P. Gorry, S. Turville, 2021, Viruses.

Inhibition of catechol-O-methyl transferase (COMT) by tolcapone restores reductions in microtubule-associated protein 2 (MAP2) and synaptophysin (SYP) following exposure of neuronal cells to neurotropic HIV

M. Churchill, I. Everall, P. Gorry, 2015, Journal of NeuroVirology.

The NRTIs Lamivudine, Stavudine and Zidovudine Have Reduced HIV-1 Inhibitory Activity in Astrocytes

M. Churchill, S. Wesselingh, B. Brew, 2013, PloS one.

Genetic and functional heterogeneity of CNS-derived tat alleles from patients with HIV-associated dementia

M. Churchill, S. Wesselingh, P. Gorry, 2011, Journal of NeuroVirology.

Is specific HIV eradication from the brain possible or needed?

M. Churchill, S. Lewin, B. Brew, 2013, Expert opinion on biological therapy.

Chronic immune activation and gut barrier dysfunction is associated with neuroinflammation in ART-suppressed SIV+ rhesus macaques

M. Churchill, B. Brew, M. Paiardini, 2023, PLoS pathogens.

Increased Sensitivity to Broadly Neutralizing Antibodies of End-Stage Disease R5 HIV-1 Correlates with Evolution in Env Glycosylation and Charge

M. Churchill, J. Albert, E. Fenyö, 2011, PloS one.

Toxicity and in vitro activity of HIV-1 latency-reversing agents in primary CNS cells

M. Churchill, S. Lewin, D. Purcell, 2016, Journal of NeuroVirology.

HIV-1 transcriptional regulation in the central nervous system and implications for HIV cure research

M. Churchill, S. Wesselingh, P. Gorry, 2015, Journal of NeuroVirology.

Reduced basal transcriptional activity of central nervous system-derived HIV type 1 long terminal repeats.

M. Churchill, S. Wesselingh, E. Crespan, 2012, AIDS research and human retroviruses.

Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissues

M. Churchill, P. Gorry, P. Ramsland, 2011, Retrovirology.

Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells

Suha M. Saleh, M. Churchill, S. Lewin, 2013, AIDS.

Variation in cell-associated unspliced HIV RNA on antiretroviral therapy is associated with the circadian regulator brain-and-muscle-ARNT-like-1

Christina C. Chang, A. Perelson, N. Hengartner, 2018, AIDS.

Analysis of Clinical HIV-1 Strains with Resistance to Maraviroc Reveals Strain-Specific Resistance Mutations, Variable Degrees of Resistance, and Minimal Cross-Resistance to Other CCR5 Antagonists.

M. Churchill, S. Lewin, J. Flynn, 2017, AIDS research and human retroviruses.

Reliable Genotypic Tropism Tests for the Major HIV-1 Subtypes

P. Harrigan, M. Churchill, P. Gorry, 2015, Scientific Reports.

Frequency and Env determinants of HIV-1 subtype C strains from antiretroviral therapy-naive subjects that display incomplete inhibition by maraviroc

M. Churchill, J. Flynn, P. Gorry, 2016, Retrovirology.

Adaptation of the intact proviral DNA assay to a nanowell-based digital PCR platform

M. Churchill, S. Lewin, Michael Roche, 2023, Journal of virus eradication.

Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of Antiretroviral Therapy-Naïve Subjects with Progressive HIV-1 Subtype C Infection

H. Ullum, M. Churchill, D. Purcell, 2013, PloS one.

Genetic and functional analysis of R5X4 human immunodeficiency virus type 1 envelope glycoproteins derived from two individuals homozygous for the CCR5delta32 allele.

M. Churchill, D. Purcell, S. Wesselingh, 2006, Journal of virology.

Designer antigens for elicitation of broadly neutralizing antibodies against HIV

M. Churchill, P. Gorry, T. Kok, 2014, Clinical & translational immunology.

Covariance of Charged Amino Acids at Positions 322 and 440 of HIV-1 Env Contributes to Coreceptor Specificity of Subtype B Viruses, and Can Be Used to Improve the Performance of V3 Sequence-Based Coreceptor Usage Prediction Algorithms

M. Churchill, P. Gorry, P. Ramsland, 2014, PloS one.

CoRSeqV3-C: a novel HIV-1 subtype C specific V3 sequence based coreceptor usage prediction algorithm

M. Churchill, P. Gorry, M. Jakobsen, 2013, Retrovirology.

HIV integration and the establishment of latency in CCL19-treated resting CD4+ T cells require activation of NF-κB

M. Churchill, S. Lewin, J. Mak, 2016, Retrovirology.

Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV

M. Churchill, S. Lewin, B. Brew, 2023, Annals of neurology.

HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entry

M. Churchill, S. Lewin, P. Gorry, 2011, Retrovirology.

Identification of HIV transmitting CD11c+ human epidermal dendritic cells

Kirstie M. Bertram, M. Churchill, M. Haniffa, 2019, Nature Communications.

Possible clearance of transfusion-acquired nef/LTR-deleted attenuated HIV-1 infection by an elite controller with CCR5 Δ32 heterozygous and HLA-B57 genotype

M. Churchill, D. Cooper, A. Kelleher, 2019, Journal of virus eradication.

Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissues

M. Churchill, P. Gorry, P. Ramsland, 2011, Retrovirology.

Tissue-Specific Sequence Alterations in the Human Immunodeficiency Virus Type 1 Envelope Favoring CCR5 Usage Contribute to Persistence of Dual-Tropic Virus in the Brain

M. Churchill, D. Purcell, S. Wesselingh, 2009, Journal of Virology.

Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS

M. Churchill, P. Gorry, L. Gray, 2007, Retrovirology.

Asn 362 in Gp120 Contributes to Enhanced Fusogenicity by Ccr5- Restricted Hiv-1 Envelope Glycoprotein Variants from Patients with Aids Asn 362 in Gp120 Contributes to Enhanced Fusogenicity by Ccr5-restricted Hiv-1 Envelope Glycoprotein Variants from Patients with Aids

M. Churchill, P. Gorry, L. Gray, 2022 .

The rev-responsive element negatively regulates human immunodeficiency virus type 1 env mRNA expression in primate cells

M. Churchill, M. Rosenberg, M. J. Churchill, 1996, Journal of virology.

Primary HIV-1 R5 isolates from end-stage disease display enhanced viral fitness in parallel with increased gp120 net charge.

M. Churchill, D. Purcell, J. Albert, 2008, Virology.

009.3 Relibale genotypic tropism tests for the major hiv-1 subtypes

M. Churchill, L. Gray, P. Gorry, 2015 .

CoRSeqV3-C: a novel HIV-1 subtype C specific V3 sequence based coreceptor usage prediction algorithm

M. Churchill, P. Gorry, M. Jakobsen, 2013, Retrovirology.

HIV transcription persists in the brain of virally suppressed people with HIV

M. Churchill, P. Gorry, T. Angelovich, 2024, PLoS pathogens.

M. Churchill, I. Everall, P. Gorry, 2015, Journal of NeuroVirology.