Dongwei Kang

发表

Synthesis and Preliminary Antiviral Activities of Piperidine‐substituted Purines against HIV and Influenza A/H1N1 Infections

E. De Clercq, Dongwei Kang, Zengjun Fang, 2015, Chemical biology & drug design.

Discovery and characterization of novel imidazopyridine derivative CHEQ-2 as a potent CDC25 inhibitor and promising anticancer drug candidate.

Peng Zhan, Dongwei Kang, Yu'ning Song, 2014, European journal of medicinal chemistry.

Development of Novel Dihydrofuro[3,4-d]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Journal of medicinal chemistry.

Exploiting the hydrophobic channel of the NNIBP: Discovery of novel diarylpyrimidines as HIV-1 NNRTIs against wild-type and K103N mutant viruses.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Bioorganic & medicinal chemistry.

Boronic acid-containing diarylpyrimidine derivatives as novel HIV-1 NNRTIs: Design, synthesis and biological evaluation

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021 .

Identification of novel potent HIV-1 inhibitors by exploiting the tolerant regions of the NNRTIs binding pocket.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, European journal of medicinal chemistry.

Discovery of Novel Dihydrothiopyrano[4,3-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs with Significantly Reduced hERG Inhibitory Activity and Improved Resistance Profiles.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Journal of medicinal chemistry.

Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV‑1 non-nucleoside reverse transcriptase inhibitors

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Bioorganic & Medicinal Chemistry.

In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, European journal of medicinal chemistry.

Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties.

E. De Clercq, Dongwei Kang, Boshi Huang, 2020, European journal of medicinal chemistry.

Structure-Activity Relationship Exploration of NNIBP Tolerant Region I Leads to Potent HIV-1 NNRTIs.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, ACS infectious diseases.

Discovery and Characterization of Fluorine-Substituted Diarylpyrimidines Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel.

Peng Zhan, Dongwei Kang, Yanying Sun, 2020, Journal of medicinal chemistry.

Structure-Based Bioisosterism Yields HIV 1 NNRTIs with Improved Drug Resistance Profiles and Favorable Pharmacokinetic Properties.

E. De Clercq, Dongwei Kang, Zengjun Fang, 2020, Journal of medicinal chemistry.

Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, European journal of medicinal chemistry.

Design, synthesis, and evaluation of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, European journal of medicinal chemistry.

Discovery of piperidine-substituted thiazolo[5,4-d]pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors

E. De Clercq, Dongwei Kang, Boshi Huang, 2019, Communications Chemistry.

Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2017, ACS medicinal chemistry letters.

Novel diarylpyrimidines and diaryltriazines as potent HIV-1 NNRTIs with dramatically improved solubility: a patent evaluation of US20140378443A1

Dongwei Kang, Boshi Huang, P. Zhan, 2016, Expert opinion on therapeutic patents.

Current insights into anti-HIV drug discovery and development: a review of recent patent literature (2014–2017)

Peng Zhan, Dongwei Kang, Gaochan Wu, 2018, Expert opinion on therapeutic patents.

Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the "NNRTI Adjacent" Binding Site.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2018, ACS medicinal chemistry letters.

Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery.

Dongwei Kang, Boshi Huang, C. Pannecouque, 2018, ACS medicinal chemistry letters.

Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries.

Dongwei Kang, P. Zhan, Xinyong Liu, 2019, European journal of medicinal chemistry.

Overview of Recent Strategic Advances in Medicinal Chemistry.

Peng Zhan, Yuning Song, Dongwei Kang, 2019, Journal of medicinal chemistry.

Contemporary medicinal-chemistry strategies for discovery of blood coagulation factor Xa inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2019, Expert opinion on drug discovery.

Inhibitors of Influenza Virus Polymerase Acidic (PA) Endonuclease: Contemporary Developments and Perspectives.

Dongwei Kang, Boshi Huang, P. Zhan, 2017, Journal of medicinal chemistry.

Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2019, European journal of medicinal chemistry.

Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus.

E. De Clercq, Dongwei Kang, Boshi Huang, 2018, European journal of medicinal chemistry.

The discovery of novel diarylpyri(mi)dine derivatives with high level activity against a wide variety of HIV-1 strains as well as against HIV-2.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2018, Bioorganic & medicinal chemistry.

Arylazolyl(azinyl)thioacetanilides. Part 20: Discovery of novel purinylthioacetanilides derivatives as potent HIV-1 NNRTIs via a structure-based bioisosterism approach.

E. De Clercq, Dongwei Kang, Boshi Huang, 2016, Bioorganic & medicinal chemistry.

Fragment-based approaches to anti-HIV drug discovery: state of the art and future opportunities

Dongwei Kang, Boshi Huang, P. Zhan, 2015, Expert opinion on drug discovery.

Design, synthesis and evaluation of novel HIV-1 NNRTIs with dual structural conformations targeting the entrance channel of the NNRTI binding pocket.

E. De Clercq, Dongwei Kang, Boshi Huang, 2016, European journal of medicinal chemistry.

Recent developments in the medicinal chemistry of single boron atom-containing compounds

Dongwei Kang, P. Zhan, Xinyong Liu, 2021, Acta pharmaceutica Sinica. B.

Newly Emerging Strategies in Antiviral Drug Discovery: Dedicated to Prof. Dr. Erik De Clercq on Occasion of His 80th Anniversary

Dongwei Kang, Boshi Huang, P. Zhan, 2022, Molecules.

Punicalagin is a neuraminidase inhibitor of influenza viruses

Dongwei Kang, P. Zhan, Xinyong Liu, 2020, Journal of medical virology.

Recent Developments in Small Molecular HIV‐1 and Hepatitis B Virus RNase H Inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2020, Advances in Metallodrugs.

2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Journal of medicinal chemistry.

Identification of C5-NH2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability.

Dongwei Kang, P. Zhan, Xinyong Liu, 2021, Journal of medicinal chemistry.

Discovery of Non‐Peptide Small Molecular CXCR4 Antagonists as anti‐HIV Agents: Recent Advances and Future Opportunities

Dongwei Kang, Boshi Huang, P. Zhan, 2016 .

Discovery of non-peptide small molecular CXCR4 antagonists as anti-HIV agents: Recent advances and future opportunities.

Dongwei Kang, Boshi Huang, P. Zhan, 2016, European journal of medicinal chemistry.

A N-propionylsulfonamide prodrug of K-5a2 provided improved aqueous solubility and hERG inhibition

Dongwei Kang, C. Pannecouque, P. Zhan, 2020 .

Novel fused pyrimidine and isoquinoline derivatives as potent HIV-1 NNRTIs: a patent evaluation of WO2016105532A1, WO2016105534A1 and WO2016105564A1

Dongwei Kang, P. Zhan, Xinyong Liu, 2017, Expert opinion on therapeutic patents.

Design, Synthesis, and Evaluation of a Set of Carboxylic Acid and Phosphate Prodrugs Derived from HBV Capsid Protein Allosteric Modulator NVR 3-778

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Molecules.

Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel".

E. De Clercq, Dongwei Kang, C. Pannecouque, 2018, Organic & biomolecular chemistry.

Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability.

Dongwei Kang, P. Zhan, Xinyong Liu, 2020, Journal of medicinal chemistry.

Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of tacrine-1,2,3-triazole derivatives as potent cholinesterase inhibitors.

Dongwei Kang, Boshi Huang, Huiqing Liu, 2018, MedChemComm.

Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7.

E. De Clercq, Dongwei Kang, Boshi Huang, 2020, Bioorganic & Medicinal Chemistry Letters.

Discovery and optimizing polycyclic pyridone compounds as anti-HBV agents

Dongwei Kang, P. Zhan, Xinyong Liu, 2020, Expert opinion on therapeutic patents.

HIV-1 capsid inhibitors: a sword to destroy the virus.

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Future medicinal chemistry.

Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2019, Bioorganic & medicinal chemistry.

Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity.

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Journal of medicinal chemistry.

Design, Synthesis, and Mechanism Study of Benzenesulfonamide-containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, Journal of medicinal chemistry.

Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Journal of medicinal chemistry.

Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Chemical Society reviews.

Design, Synthesis and Structure—Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Molecules.

Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, European journal of medicinal chemistry.

Contemporary medicinal-chemistry strategies for the discovery of selective butyrylcholinesterase inhibitors.

Dongwei Kang, P. Zhan, Xinyong Liu, 2019, Drug discovery today.

An improved synthesis approach of the HIV-1 inhibitor RDEA427, a pyrrolo[2,3-d]pyrimidine derivative

Dongwei Kang, Boshi Huang, P. Zhan, 2016 .

Design, synthesis, and biological evaluation of piperidinyl‐substituted [1,2,4]triazolo[1,5‐a]pyrimidine derivatives as potential anti‐HIV‐1 agents with reduced cytotoxicity

E. De Clercq, Dongwei Kang, Boshi Huang, 2020, Chemical biology & drug design.

Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2019, Organic & biomolecular chemistry.

Discovery of novel pyridazinylthioacetamides as potent HIV-1 NNRTIs using a structure-based bioisosterism approach

Peng Zhan, Erik De Clercq, Ye Tian, 2013 .

First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain.

E. De Clercq, Dongwei Kang, Boshi Huang, 2018, Bioorganic & medicinal chemistry letters.

"Old Dogs with New Tricks": exploiting alternative mechanisms of action and new drug design strategies for clinically validated HIV targets.

Peng Zhan, Dongwei Kang, Yu'ning Song, 2014, Molecular bioSystems.

Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2021, Acta Pharmaceutica Sinica B.

Search, Identification, and Design of Effective Antiviral Drugs Against Pandemic Human Coronaviruses.

Dongwei Kang, P. Zhan, Xinyong Liu, 2021, Advances in experimental medicine and biology.

Novel urate transporter 1 (URAT1) inhibitors: a review of recent patent literature (2016–2019)

Dongwei Kang, P. Zhan, Xinyong Liu, 2019, Expert opinion on therapeutic patents.

Molecular design opportunities presented by solvent‐exposed regions of target proteins

Peng Zhan, Erik De Clercq, Yuning Song, 2019, Medicinal research reviews.

Design, synthesis, and antiviral evaluation of novel hydrazone‐substituted thiophene[3,2‐d]pyrimidine derivatives as potent human immunodeficiency virus‐1 inhibitors

E. De Clercq, Dongwei Kang, C. Pannecouque, 2018, Chemical biology & drug design.

New techniques and strategies in drug discovery

Guan Wang, Zhen Zhang, Jing Guo, 2020, Chinese Chemical Letters.

The development of an effective synthetic route of rilpivirine

Dongwei Kang, P. Zhan, Xinyong Liu, 2021, BMC Chemistry.

Novel indolylarylsulfone derivatives as covalent HIV-1 reverse transcriptase inhibitors specifically targeting the drug-resistant mutant Y181C.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, Bioorganic & medicinal chemistry.

Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs

E. De Clercq, Dongwei Kang, Boshi Huang, 2019, Acta pharmaceutica Sinica. B.

First discovery of novel 3-hydroxy-quinazoline-2,4(1H,3H)-diones as specific anti-vaccinia and adenovirus agents via ‘privileged scaffold’ refining approach

Peng Zhan, Lieve Naesens, Heng Zhang, 2016, Bioorganic & Medicinal Chemistry Letters.

Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant.

Peng Zhan, Xiao Ding, Ye Tian, 2018, Journal of medicinal chemistry.

Recent applications of click chemistry in drug discovery

Peng Zhan, Dongwei Kang, Xinyong Liu, 2019, Expert opinion on drug discovery.

Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, European journal of medicinal chemistry.

From design to biological mechanism evaluation of phenylalanine-bearing HIV-1 capsid inhibitors targeting a vital assembly interface

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Chinese Chemical Letters.

Design, synthesis, and antiviral evaluation of novel piperidine-substituted arylpyrimidines as HIV-1 NNRTIs by exploring the hydrophobic channel of NNIBP.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Bioorganic chemistry.

Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies.

E. De Clercq, Dongwei Kang, Boshi Huang, 2021, Journal of medicinal chemistry.

Discovery, optimization, and target identification of novel coumarin derivatives as HIV-1 reverse transcriptase-associated ribonuclease H inhibitors.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, European journal of medicinal chemistry.

Discovery of potent HIV‐1 non‐nucleoside reverse transcriptase inhibitors by exploring the structure–activity relationship of solvent‐exposed regions I

E. De Clercq, Dongwei Kang, C. Pannecouque, 2019, Chemical biology & drug design.

Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles.

Peng Zhan, F. J. Luque, Ye Tian, 2019, Journal of medicinal chemistry.

Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties.

Peng Zhan, Jian Zhang, F. J. Luque, 2019, Journal of medicinal chemistry.

Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors

T. Steitz, Dongwei Kang, C. Pannecouque, 2018, eLife.

Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives as potent HIV-1 NNRTIs.

E. De Clercq, Dongwei Kang, Boshi Huang, 2017, European journal of medicinal chemistry.

Identification of Novel Diarylpyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors by Exploring the Primer Grip Region

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Pharmaceuticals.

Efficient drug discovery by rational lead hybridization based on crystallographic overlay.

Jian Zhang, Peng Zhan, Shuo Zhang, 2019, Drug discovery today.

Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles.

Peng Zhan, Xiao Ding, Dongwei Kang, 2016, Journal of medicinal chemistry.

Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors' Binding Pocket.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, Journal of medicinal chemistry.

Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Molecules.

Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitors.

Dongwei Kang, P. Zhan, Xinyong Liu, 2021, Bioorganic & medicinal chemistry.

Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, International Journal of Molecular Sciences.

Discovery of novel 1,2,4‐triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Journal of medical virology.

Structure-Based Discovery and Characterization of a Preclinical Drug Candidate for the Treatment of HIV-1 Infection

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Viruses.

Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants.

Peng Zhan, Xiao Ding, Ye Tian, 2017, Journal of medicinal chemistry.

Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.

Peng Zhan, Xiao Ding, Ye Tian, 2018, Journal of medicinal chemistry.

Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies.

Dongwei Kang, P. Zhan, Xinyong Liu, 2023, Bioorganic chemistry.

Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2019, RSC advances.

Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, Acta pharmaceutica Sinica. B.

Chemical space exploration around indolylarylsulfone scaffold led to a novel class of highly active HIV-1 NNRTIs with spiro structural features.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of novel 5‐Alkyl‐6‐Adamantylmethylpyrimidin‐4(3H)‐ones as HIV‐1 non‐nucleoside reverse‐transcriptase inhibitors

E. De Clercq, Dongwei Kang, Boshi Huang, 2016, Chemical biology & drug design.

Synthesis and Biological Evaluation of a Series of 2‐((1‐substituted‐1H‐1,2,3‐triazol‐4‐yl)methylthio)‐6‐(naphthalen‐1‐ylmethyl)pyrimidin‐4(3H)‐one As Potential HIV‐1 Inhibitors

Peng Zhan, Dongwei Kang, Christophe Pannecouque, 2015, Chemical biology & drug design.

Novel RNase H inhibitors blocking RNA-directed strand displacement DNA synthesis by HIV-1 reverse transcriptase.

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Journal of molecular biology.

Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Journal of medicinal chemistry.

Combination of 2D and 3D-QSAR studies on DAPY and DANA derivatives as potent HIV-1 NNRTIs

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Journal of Molecular Structure.

In Silico Discovery of Small-Molecule Inhibitors Targeting SARS-CoV-2 Main Protease

Dongwei Kang, Na Liu, Menghan Gao, 2023, Molecules.

Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library.

Fangfang Zhang, Peng Zhan, Ye Tian, 2018, European journal of medicinal chemistry.

Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, RSC medicinal chemistry.

Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket.

E. De Clercq, Dongwei Kang, Boshi Huang, 2016, European journal of medicinal chemistry.

Discovery of ligustrazine and chalcone derivatives as novel viral nucleoprotein nuclear export inhibitors against influenza viruses

Dongwei Kang, P. Zhan, Xinyong Liu, 2023, Journal of medical virology.

Discovery of novel anti-influenza agents via contemporary medicinal chemistry strategies (2014-2018 update).

Dongwei Kang, Zengjun Fang, P. Zhan, 2019, Future medicinal chemistry.

Author response: Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors

T. Steitz, Dongwei Kang, C. Pannecouque, 2018 .

Medicinal chemistry strategies towards the development of non-covalent SARS-CoV-2 Mpro inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2023, Acta pharmaceutica Sinica. B.

Identification of Boronate-Containing Diarylpyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

Dongwei Kang, C. Pannecouque, P. Zhan, 2022, Molecules.

Design, Synthesis, and Acetylcholinesterase Inhibition Assay of Novel 9-(1-(Substituted-benzyl)piperidin-4-yl)-2-chloro-9H-purin-6-amine Derivatives

Dongwei Kang, P. Zhan, Xinyong Liu, 2013 .

Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors

T. Steitz, Dongwei Kang, C. Pannecouque, 2018, eLife.

Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization.

Peng Zhan, Ye Tian, Dongwei Kang, 2017, European journal of medicinal chemistry.

5-Cyano substituted diarylpyridines as potent HIV-1 NNRTIs: Rational design, synthesis, and activity evaluation.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, European journal of medicinal chemistry.

Novel diaryltriazines with a picolinonitrile moiety as potent HIV-1 RT inhibitors: a patent evaluation of WO2016059647(A2)

Dongwei Kang, Boshi Huang, P. Zhan, 2017, Expert opinion on therapeutic patents.

Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors

E. De Clercq, Dongwei Kang, Boshi Huang, 2023, Communications chemistry.

Ligand recognition and G protein coupling of the human itch receptor MRGPRX1

Dongwei Kang, Xinzhong Dong, Lu Tie, 2023, Nature communications.

Structural and signaling mechanisms of TAAR1 enabled preferential agonist design

Dongwei Kang, Xinyong Liu, Fan Yang, 2023, Cell.

Escaping from Flatland: Multiparameter Optimization Leads to the Discovery of Novel Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Human Immunodeficiency Virus-1 Non-nucleoside Reverse Transcriptase Inhibitors with Superior Antiviral Activities against Non-nucleoside Reverse Transcriptase Inhibito

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, Journal of medicinal chemistry.

Discovery of GluN2A subtype-selective N-methyl-d-aspartate (NMDA) receptor ligands

Dongwei Kang, Boshi Huang, Xinyong Liu, 2024, Acta pharmaceutica Sinica. B.

Multifunctional agents against Alzheimer's disease based on oxidative stress: Polysubstituted pyrazine derivatives synthesized by multicomponent reactions.

Dongwei Kang, P. Zhan, Xinyong Liu, 2023, Bioorganic & medicinal chemistry.

Structure-based design, synthesis, and biological characterization of indolylarylsulfone derivatives as novel human immunodeficiency virus type 1 inhibitors with potent antiviral activities and favorable drug-like profiles.

Dongwei Kang, C. Pannecouque, P. Zhan, 2024, Journal of medical virology.

Discovery of 2,4,6-trisubstituted Pyrimidine Derivatives as Novel Potent HIV-1 NNRTIs by Exploiting the Tolerant Region II of the NNIBP

Dongwei Kang, C. Pannecouque, P. Zhan, 2024, European Journal of Medicinal Chemistry.

Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants

Dongwei Kang, C. Pannecouque, P. Zhan, 2023, Acta pharmaceutica Sinica. B.

Identification of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase.

Dongwei Kang, C. Pannecouque, P. Zhan, 2022, European journal of medicinal chemistry.