Huiqing Liu

发表

Synthesis and Preliminary Antiviral Activities of Piperidine‐substituted Purines against HIV and Influenza A/H1N1 Infections

E. De Clercq, Dongwei Kang, Zengjun Fang, 2015, Chemical biology & drug design.

Anti-inflammatory Effect of Acetylpuerarin on Eicosanoid Signaling Pathway in Primary Rat Astrocytes

Huiqing Liu, Yanxiao Xiang, Xinbing Wei, 2014, Journal of Molecular Neuroscience.

Angiotensin II stimulates intercellular adhesion molecule-1 via an AT1 receptor/nuclear factor-kappaB pathway in brain microvascular endothelial cells.

Huiqing Liu, Alex F. Chen, Xiumei Zhang, 2006, Life sciences.

Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement.

E. De Clercq, Boshi Huang, Huiqing Liu, 2017, European journal of medicinal chemistry.

Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches.

E. De Clercq, Boshi Huang, Huiqing Liu, 2015, European journal of medicinal chemistry.

Tetramethylpyrazine Analogue CXC195 Protects Against Dopaminergic Neuronal Apoptosis via Activation of PI3K/Akt/GSK3β Signaling Pathway in 6-OHDA-Induced Parkinson’s Disease Mice

Huiqing Liu, Xinyong Liu, Xinbing Wei, 2017, Neurochemical Research.

Tetramethylpyrazine Analogue CXC195 Protects against Cerebral Ischemia/Reperfusion Injury in the Rat by an Antioxidant Action via Inhibition of NADPH Oxidase and iNOS Expression

Huiqing Liu, Xinyong Liu, Xinbing Wei, 2013, Pharmacology.

NOD2 is Involved in the Inflammatory Response after Cerebral Ischemia-Reperfusion Injury and Triggers NADPH Oxidase 2-Derived Reactive Oxygen Species

Huiqing Liu, S. Yan, Xinbing Wei, 2015, International journal of biological sciences.

β‐arrestin 2 negatively regulates NOD2 signalling pathway through association with TRAF6 in microglia after cerebral ischaemia/reperfusion injury

Huiqing Liu, Bing Wang, Xinbing Wei, 2019, Journal of cellular and molecular medicine.

USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3

Huiqing Liu, Chunhong Ma, Chengjiang Gao, 2021, Autophagy.

Angiotensin II stimulates intercellular adhesion molecule-1 via an AT1 receptor/nuclear factor-κB pathway in brain microvascular endothelial cells

Huiqing Liu, Alex F. Chen, Xinbing Wei, 2006 .

Losartan, an angiotensin II type 1 receptor blocker, ameliorates cerebral ischemia-reperfusion injury via PI3K/Akt-mediated eNOS phosphorylation

Huiqing Liu, F. Yi, Yanxiao Xiang, 2012, Brain Research Bulletin.

Inhibition of sPLA2-IIA Prevents LPS-Induced Neuroinflammation by Suppressing ERK1/2-cPLA2α Pathway in Mice Cerebral Cortex

Huiqing Liu, Yanxiao Xiang, Xinbing Wei, 2013, PloS one.

Design, synthesis and biological evaluation of tacrine-1,2,3-triazole derivatives as potent cholinesterase inhibitors.

Dongwei Kang, Boshi Huang, Huiqing Liu, 2018, MedChemComm.

Tetramethylpyrazine Analogue CXC195 Ameliorates Cerebral Ischemia–reperfusion Injury by Regulating Endothelial Nitric Oxide Synthase Phosphorylation Via PI3K/Akt Signaling

Huiqing Liu, Xinyong Liu, S. Yan, 2014, Neurochemical Research.

Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion-induced apoptosis through PI3K/Akt/GSK3β pathway in rats

Huiqing Liu, Xinyong Liu, Xinbing Wei, 2014, Neurochemistry International.

Hydroxysafflor Yellow A Protects Against Cerebral Ischemia–Reperfusion Injury by Anti-apoptotic Effect Through PI3K/Akt/GSK3β Pathway in Rat

Huiqing Liu, Yanxiao Xiang, Xinbing Wei, 2013, Neurochemical Research.

Hydroxysafflor yellow A protects rat brains against ischemia-reperfusion injury by antioxidant action

Fenghua Fu, Huiqing Liu, J. An, 2005, Neuroscience Letters.

Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on crystallographic overlays.

Peng Zhan, Jan Balzarini, Christophe Pannecouque, 2014, Bioorganic & medicinal chemistry.

Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives.

Peng Zhan, Ye Tian, Christophe Pannecouque, 2014, Bioorganic & medicinal chemistry.

Arylazolyl(azinyl)thioacetanilides. Part 16: Structure-based bioisosterism design, synthesis and biological evaluation of novel pyrimidinylthioacetanilides as potent HIV-1 inhibitors.

Peng Zhan, Jan Balzarini, Christophe Pannecouque, 2014, Bioorganic & medicinal chemistry.

Arylazolyl(azinyl)thioacetanilides. Part 10: design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors.

Peng Zhan, Jan Balzarini, Xuwang Chen, 2012, Bioorganic & medicinal chemistry.

Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV‐1 RNase H inhibitors

Peng Zhan, Jacob Kongsted, Luis Menéndez-Arias, 2019, Chemical biology & drug design.

Design, Synthesis, and Biological Evaluation of Novel Benzoyl Diarylamine/ether Derivatives as Potential Anti‐HIV‐1 Agents

E. De Clercq, Lingzi Zhang, Huiqing Liu, 2015, Chemical biology & drug design.

Tetramethylpyrazine Analogue CXC195 Ameliorates Cerebral Ischemia–reperfusion Injury by Regulating Endothelial Nitric Oxide Synthase Phosphorylation Via PI3K/Akt Signaling

Huiqing Liu, Xinyong Liu, S. Yan, 2015, Neurochemical Research.

USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS

Huiqing Liu, Chunhong Ma, Chengjiang Gao, 2021, Nature Communications.

NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson’s disease

Huiqing Liu, Haitao Wen, Chengjiang Gao, 2018, Journal of Neuroinflammation.

Discovery of nitropyridine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors via a structure-based core refining approach.

Peng Zhan, Christophe Pannecouque, E. De Clercq, 2014, European journal of medicinal chemistry.

Discovery of novel diarylpyrimidines as potent HIV NNRTIs via a structure-guided core-refining approach.

Peng Zhan, Jan Balzarini, Ye Tian, 2014, European journal of medicinal chemistry.

The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR

Huiqing Liu, Chengjiang Gao, Xiaomeng Song, 2021, Redox biology.

Activation of the Omega-3 Fatty Acid Receptor GPR120 Protects against Focal Cerebral Ischemic Injury by Preventing Inflammation and Apoptosis in Mice

Huiqing Liu, Chengjiang Gao, Yi Zheng, 2018, The Journal of Immunology.

Design, Synthesis, and Biological Evaluation of Novel 3,5‐Disubstituted‐1,2,6‐Thiadiazine‐1,1‐Dione Derivatives as HIV‐1 NNRTIs

Peng Zhan, Jan Balzarini, Ye Tian, 2013, Chemical biology & drug design.

Synthesis and Biological Evaluation of a Series of 2‐((1‐substituted‐1H‐1,2,3‐triazol‐4‐yl)methylthio)‐6‐(naphthalen‐1‐ylmethyl)pyrimidin‐4(3H)‐one As Potential HIV‐1 Inhibitors

Peng Zhan, Dongwei Kang, Christophe Pannecouque, 2015, Chemical biology & drug design.

Design, Synthesis, and Anti‐HIV Evaluation of Novel Triazine Derivatives Targeting the Entrance Channel of the NNRTI Binding Pocket

E. De Clercq, Huiqing Liu, C. Pannecouque, 2015, Chemical biology & drug design.

Hydroxysafflor Yellow A Protects Against Cerebral Ischemia–Reperfusion Injury by Anti-apoptotic Effect Through PI3K/Akt/GSK3β Pathway in Rat

Huiqing Liu, Yanxiao Xiang, Xinbing Wei, 2013, Neurochemical Research.

Pharmacokinetics and metabolism of Chf197, a ligustrazine derivative, in rats

Huiqing Liu, Xinyong Liu, Chun-min Wei, 2015, Fundamental & clinical pharmacology.

Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 2: discovery of novel [1,2,4]Triazolo[1,5-a]pyrimidines using a structure-guided core-refining approach.

Peng Zhan, Ye Tian, Christophe Pannecouque, 2014, European journal of medicinal chemistry.

Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines.

E. De Clercq, Boshi Huang, Huiqing Liu, 2015, European journal of medicinal chemistry.

Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs.

Peng Zhan, Jan Balzarini, Xuwang Chen, 2014, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs.

Peng Zhan, Jan Balzarini, Christophe Pannecouque, 2013, Bioorganic & medicinal chemistry.

Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, Huiqing Liu, C. Pannecouque, 2013, Bioorganic & medicinal chemistry letters.

NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson’s disease

Huiqing Liu, Haitao Wen, Chengjiang Gao, 2018, Journal of Neuroinflammation.

Anti-inflammatory Effect of Acetylpuerarin on Eicosanoid Signaling Pathway in Primary Rat Astrocytes

Huiqing Liu, Yanxiao Xiang, Xinbing Wei, 2014, Journal of Molecular Neuroscience.

Losartan protects against cerebral ischemia/reperfusion‐induced apoptosis through &bgr;‐arrestin1‐mediated phosphorylation of Akt

Huiqing Liu, Xinbing Wei, Lin Chen, 2017, European journal of pharmacology.

Discovery of novel DAPY-IAS hybrid derivatives as potential HIV-1 inhibitors using molecular hybridization based on crystallographic overlays.

Peng Zhan, Xueshun Wang, Christophe Pannecouque, 2017, Bioorganic & medicinal chemistry.

Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization.

Peng Zhan, Ye Tian, Dongwei Kang, 2017, European journal of medicinal chemistry.

Discovery of nitropyridine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors via a structure-based core refining approach.

E. De Clercq, Huiqing Liu, C. Pannecouque, 2014, European journal of medicinal chemistry.

Discovery of Piperidine‐Linked Pyridine Analogues as Potent Non‐nucleoside HIV‐1 Reverse Transcriptase Inhibitors

Huiqing Liu, C. Pannecouque, Xinyong Liu, 2013, ChemMedChem.

Design, Synthesis, and Anti‐HIV Evaluation of Novel Triazine Derivatives Targeting the Entrance Channel of the NNRTI Binding Pocket

E. De Clercq, Huiqing Liu, C. Pannecouque, 2015, Chemical biology & drug design.