C. Pannecouque

发表

Synthesis and Preliminary Antiviral Activities of Piperidine‐substituted Purines against HIV and Influenza A/H1N1 Infections

E. De Clercq, Dongwei Kang, Zengjun Fang, 2015, Chemical biology & drug design.

Bioactive Natural Products Prioritization Using Massive Multi-informational Molecular Networks.

C. Pannecouque, L. Marcourt, J. Neyts, 2017, ACS chemical biology.

Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata.

C. Pannecouque, J. Neyts, F. Roussi, 2015, Journal of natural products.

Jatrophane diterpenes as inhibitors of chikungunya virus replication: structure-activity relationship and discovery of a potent lead.

C. Pannecouque, J. Neyts, P. Retailleau, 2014, Journal of natural products.

Design, Synthesis, and Molecular Docking Studies of a Conjugated Thiadiazole-Thiourea Scaffold as Antituberculosis Agents.

P. Yogeeswari, D. Sriram, E. De Clercq, 2016, Biological & pharmaceutical bulletin.

Development of Novel Dihydrofuro[3,4-d]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Journal of medicinal chemistry.

Exploiting the hydrophobic channel of the NNIBP: Discovery of novel diarylpyrimidines as HIV-1 NNRTIs against wild-type and K103N mutant viruses.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Bioorganic & medicinal chemistry.

Hydrophobic Pocket Occupation Design of Difluoro-Biphenyl-Diarylpyrimidines as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: from N-Alkylation to Methyl Hopping on the Pyrimidine Ring.

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2021, Journal of medicinal chemistry.

Boronic acid-containing diarylpyrimidine derivatives as novel HIV-1 NNRTIs: Design, synthesis and biological evaluation

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021 .

Identification of novel potent HIV-1 inhibitors by exploiting the tolerant regions of the NNRTIs binding pocket.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, European journal of medicinal chemistry.

Discovery of Novel Dihydrothiopyrano[4,3-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs with Significantly Reduced hERG Inhibitory Activity and Improved Resistance Profiles.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Journal of medicinal chemistry.

Design of the naphthyl-diarylpyrimidines as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) via structure-based extension into the entrance channel.

E. De Clercq, C. Pannecouque, H. Piao, 2021, European journal of medicinal chemistry.

Design, synthesis and anti-HIV evaluation of novel 5-substituted diarylpyrimidine derivatives as potent HIV-1 NNRTIs.

E. De Clercq, C. Pannecouque, P. Zhan, 2021, Bioorganic & medicinal chemistry.

Chemical space exploration of novel naphthyl-carboxamide-diarylpyrimidine derivatives with potent anti-HIV-1 activity.

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2021, Bioorganic chemistry.

Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV‑1 non-nucleoside reverse transcriptase inhibitors

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Bioorganic & Medicinal Chemistry.

In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, European journal of medicinal chemistry.

Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties.

E. De Clercq, Dongwei Kang, Boshi Huang, 2020, European journal of medicinal chemistry.

Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2020, Molecules.

Structure-Activity Relationship Exploration of NNIBP Tolerant Region I Leads to Potent HIV-1 NNRTIs.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, ACS infectious diseases.

Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2019, Acta pharmaceutica Sinica. B.

Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2019, Acta pharmaceutica Sinica. B.

Fragment-based discovery of sulfur-containing diarylbenzopyrimidines as novel nonnucleoside reverse transcriptase inhibitors

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2020 .

Discovery and Characterization of Fluorine-Substituted Diarylpyrimidines Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel.

Peng Zhan, Dongwei Kang, Yanying Sun, 2020, Journal of medicinal chemistry.

Structure-Based Bioisosterism Yields HIV 1 NNRTIs with Improved Drug Resistance Profiles and Favorable Pharmacokinetic Properties.

E. De Clercq, Dongwei Kang, Zengjun Fang, 2020, Journal of medicinal chemistry.

Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2020, European journal of medicinal chemistry.

Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, European journal of medicinal chemistry.

Design, synthesis, and evaluation of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, European journal of medicinal chemistry.

Discovery of piperidine-substituted thiazolo[5,4-d]pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors

E. De Clercq, Dongwei Kang, Boshi Huang, 2019, Communications Chemistry.

Follow on-based optimization of the biphenyl-DAPYs as HIV-1 nonnucleoside reverse transcriptase inhibitors against the wild-type and mutant strains.

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2019, Bioorganic chemistry.

Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2019, European journal of medicinal chemistry.

Indazolyl-substituted piperidin-4-yl-aminopyrimidines as HIV-1 NNRTIs: Design, synthesis and biological activities.

C. Pannecouque, Zhi-Qiang Xu, Fener Chen, 2019, European journal of medicinal chemistry.

Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2017, ACS medicinal chemistry letters.

Design strategies of novel NNRTIs to overcome drug resistance.

Peng Zhan, Christophe Pannecouque, E. De Clercq, 2009, Current medicinal chemistry.

Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the "NNRTI Adjacent" Binding Site.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2018, ACS medicinal chemistry letters.

Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery.

Dongwei Kang, Boshi Huang, C. Pannecouque, 2018, ACS medicinal chemistry letters.

Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle

C. Pannecouque, M. Van Ranst, J. Balzarini, 2007, Antiviral Research.

Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives.

Angela Rao, Maria Zappalà, Pietro Monforte, 2002, Farmaco.

Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives.

E. De Clercq, C. Pannecouque, J. Balzarini, 2006, Chemical & pharmaceutical bulletin.

Overview of Recent Strategic Advances in Medicinal Chemistry.

Peng Zhan, Yuning Song, Dongwei Kang, 2019, Journal of medicinal chemistry.

Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents

Sergio R. Ribone, C. Pannecouque, W. Dehaen, 2018, Bioorganic & Medicinal Chemistry Letters.

Graphene Quantum Dots Based Systems As HIV Inhibitors.

C. Pannecouque, S. Ferro, D. Iannazzo, 2018, Bioconjugate chemistry.

Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, Xiaodong Ma, 2012, European journal of medicinal chemistry.

4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: Synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation

B. Narasimhan, E. De Clercq, C. Pannecouque, 2010, European Journal of Medicinal Chemistry.

Synthesis and Anti Hiv-1 Reverse Transcriptase Evaluation of A Series of N-Mono Substituted Thiourea Derivatives

C. Pannecouque, J. Balzarini, E. Clercq, 2015 .

Non-nucleoside HIV-1 reverse transcriptase inhibitors, Part 7. Synthesis, antiviral activity, and 3D-QSAR investigations of novel 6-(1-naphthoyl) HEPT analogues.

E. De Clercq, C. Pannecouque, J. Balzarini, 2006, Chemical & pharmaceutical bulletin.

Synthesis and anti-HIV activity of carboxylated and drug-conjugated multi-walled carbon nanotubes

M. Prato, C. Pannecouque, S. Galvagno, 2015 .

Synthesis, antimycobacterial, antiviral, antimicrobial activities, and QSAR studies of isonicotinic acid-1-(substituted phenyl)-ethylidene/cycloheptylidene hydrazides

B. Narasimhan, P. Yogeeswari, D. Sriram, 2011, Medicinal Chemistry Research.

Isonicotinic acid hydrazide derivatives: synthesis, antimicrobial activity, and QSAR studies

B. Narasimhan, P. Yogeeswari, D. Sriram, 2012, Medicinal Chemistry Research.

Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase.

E. De Clercq, C. Pannecouque, E. Arnold, 2009, Journal of medicinal chemistry.

Deciphering the Role of Extracellular Vesicles Derived from ZIKV-Infected hcMEC/D3 Cells on the Blood–Brain Barrier System

C. Pannecouque, J. Swinnen, D. Schols, 2021, Viruses.

Synthesis and in vitro enzymatic and antiviral evaluation of phosphoramidate d4T derivatives as chain terminators.

C. Pannecouque, P. Herdewijn, E. Lescrinier, 2012, Organic & biomolecular chemistry.

A time-of–drug addition approach to target identification of antiviral compounds

E. De Clercq, R. Pauwels, C. Pannecouque, 2011, Nature Protocols.

env Chimeric Virus Technology for Evaluating Human Immunodeficiency Virus Susceptibility to Entry Inhibitors

E. De Clercq, C. Pannecouque, A. Vandamme, 2002, Antimicrobial Agents and Chemotherapy.

Arylazolyl(azinyl)thioacetanilides: Part 19 : Discovery of Novel Substituted Imidazo[4,5‐b]pyridin‐2‐ylthioacetanilides as Potent HIV NNRTIs Via a Structure‐based Bioisosterism Approach

E. De Clercq, Boshi Huang, C. Pannecouque, 2016, Chemical biology & drug design.

1-[2-(2-Benzoyl- and 2-benzylphenoxy)ethyl]uracils as potent anti-HIV-1 agents

A. V. Ivanov, C. Pannecouque, J. Balzarini, 2011, Bioorganic & Medicinal Chemistry.

Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2019, European journal of medicinal chemistry.

Discovery of biphenyl-substituted diarylpyrimidines as non-nucleoside reverse transcriptase inhibitors with high potency against wild-type and mutant HIV-1.

E. De Clercq, C. Pannecouque, Fener Chen, 2018, European journal of medicinal chemistry.

Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus.

E. De Clercq, Dongwei Kang, Boshi Huang, 2018, European journal of medicinal chemistry.

The discovery of novel diarylpyri(mi)dine derivatives with high level activity against a wide variety of HIV-1 strains as well as against HIV-2.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2018, Bioorganic & medicinal chemistry.

Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement.

E. De Clercq, Boshi Huang, Huiqing Liu, 2017, European journal of medicinal chemistry.

Arylazolyl(azinyl)thioacetanilides. Part 20: Discovery of novel purinylthioacetanilides derivatives as potent HIV-1 NNRTIs via a structure-based bioisosterism approach.

E. De Clercq, Dongwei Kang, Boshi Huang, 2016, Bioorganic & medicinal chemistry.

Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches.

E. De Clercq, Boshi Huang, Huiqing Liu, 2015, European journal of medicinal chemistry.

Synthesis and biological evaluation of DAPY-DPEs hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase.

E. De Clercq, C. Pannecouque, D. Daelemans, 2015, Bioorganic & medicinal chemistry.

Design, synthesis and evaluation of novel HIV-1 NNRTIs with dual structural conformations targeting the entrance channel of the NNRTI binding pocket.

E. De Clercq, Dongwei Kang, Boshi Huang, 2016, European journal of medicinal chemistry.

Pyrimidine sulfonylacetanilides with improved potency against key mutant viruses of HIV-1 by specific targeting of a highly conserved residue.

E. De Clercq, C. Pannecouque, D. Daelemans, 2015, European journal of medicinal chemistry.

Synthesis and Antiviral Activities of 3-Aralkyl-Thiomethylimidazo[1,2-b]Pyridazine Derivatives

E. De Clercq, C. Pannecouque, J. Balzarini, 2003, Antiviral chemistry & chemotherapy.

Antiviral resistance to diketo acids is associated with the mutations T66I, L74M and S230R in the HIV-1 integrase gene

C. Pannecouque, N. Neamati, T. Burke, 2002 .

CXCR 4 chemokine receptor antagonists : nickel ( II ) complexes of con fi gurationally restricted macrocycles †

C. Pannecouque, E. Clercq, D. Schols, 2012 .

2‐(2,6‐Dihalo‐phenyl)‐3‐heteroaryl‐2‐ylmethyl‐1, 3‐thiazolidin‐4‐ones: Anti‐HIV agents

Ravindra K Rawal, Christophe Pannecouque, E. De Clercq, 2008, Chemical biology & drug design.

Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents.

E. De Clercq, C. Pannecouque, J. Balzarini, 2001, Bioorganic & medicinal chemistry letters.

Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents.

E. De Clercq, C. Pannecouque, J. Balzarini, 2002, Journal of Medicinal Chemistry.

Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands.

C. Pannecouque, A. Marcello, D. Daelemans, 2014, Bioorganic & medicinal chemistry.

Expansion of the S-CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase.

C. Pannecouque, E. Clercq, Fener Chen, 2022, European journal of medicinal chemistry.

Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

C. Pannecouque, Yiming Li, E. Clercq, 2020 .

Conformational restriction design of thiophene-biphenyl-DAPY HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, Fen‐er Chen, 2019, European journal of medicinal chemistry.

Synthesis and biological evaluation of new conformationally restricted S-DABO hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase

C. Pannecouque, J. Balzarini, E. Clercq, 2014 .

Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, J. Balzarini, 2008, Bioorganic & medicinal chemistry.

Non‐Nucleoside HIV‐1 Reverse‐Transcriptase Inhibitors. Part 10

C. Pannecouque, J. Balzarini, Yue-ping Wang, 2008, Chemistry & biodiversity.

Nonnucleoside HIV-1 reverse transcriptase inhibitors; part 3. Synthesis and antiviral activity of 5-alkyl-2-[(aryl and alkyloxyl-carbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones.

E. De Clercq, C. Pannecouque, J. Balzarini, 2004, Bioorganic chemistry.

5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series.

E. De Clercq, C. Pannecouque, J. Balzarini, 2004, Bioorganic & medicinal chemistry letters.

Chelation Motifs Affecting Metal-dependent Viral Enzymes: N′-acylhydrazone Ligands as Dual Target Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain

C. Pannecouque, L. Naesens, M. Carcelli, 2017, Front. Microbiol..

Inhibition of HIV-1 Replication by a Bis-Thiadiazolbenzene-1,2-Diamine That Chelates Zinc Ions from Retroviral Nucleocapsid Zinc Fingers

C. Pannecouque, W. Dehaen, Y. Mély, 2010, Antimicrobial Agents and Chemotherapy.

Systematic evaluation of methyl ester bioisosteres in the context of developing alkenyldiarylmethanes (ADAMs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) for anti-HIV-1 chemotherapy.

C. Pannecouque, M. Cushman, R. Buckheit, 2016, Bioorganic & medicinal chemistry.

2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Journal of medicinal chemistry.

New findings on the d(TGGGAG) sequence: Surprising anti-HIV-1 activity.

C. Pannecouque, S. Noppen, S. Liekens, 2018, European journal of medicinal chemistry.

Ligand-based design of nondimethylphenyl-diarylpyrimidines with improved metabolic stability, safety and oral pharmacokinetic profiles.

E. De Clercq, C. Pannecouque, Fener Chen, 2019, Journal of medicinal chemistry.

Structure-Based Discovery of Novel NH2-Biphenyl-Diarylpyrimidines as Potent Non-Nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Safety: From NH2-Naphthyl-Diarylpyrimidine to NH2-Biphenyl-Diarylpyrimidine.

F. Chen, E. De Clercq, C. Pannecouque, 2022, Journal of medicinal chemistry.

International Journal of Antimicrobial Agents the G-quadruplex-forming Aptamer As1411 Potently Inhibits Hiv-1 Attachment to the Host Cell

C. Pannecouque, G. Palù, A. Garzino-Demo, 2022 .

A N-propionylsulfonamide prodrug of K-5a2 provided improved aqueous solubility and hERG inhibition

Dongwei Kang, C. Pannecouque, P. Zhan, 2020 .

Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, G. Maga, 2008, Bioorganic & medicinal chemistry.

Pyridine N-oxide derivatives inhibit viral transactivation by interfering with NF-kappaB binding.

E. De Clercq, C. Pannecouque, J. Balzarini, 2006, Biochemical pharmacology.

How a Modification (8‐Aza‐3‐deaza‐2′‐deoxyguanosine) Influences the Quadruplex Structure of Hotoda's 6‐Mer TGGGAG with 5′‐ and 3′‐End Modifications

E. De Clercq, C. Pannecouque, J. Balzarini, 2004, Nucleosides, Nucleotides & Nucleic Acids.

Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir).

E. De Clercq, C. Pannecouque, B. Clotet, 1998, Molecular pharmacology.

Synthesis, and in vitro Enzymatic and Antiviral Evaluation of d4T Polyphosphate Derivatives as Chain Terminators

C. Pannecouque, P. Herdewijn, Shiqiong Yang, 2012, Chemistry & biodiversity.

Synthesis and Biological Activity of N-(arylsulfonyl) Valine Hydrazones and Assistance of NMR Spectroscopy for Definitive 3D Structure

E. De Clercq, C. Pannecouque, M. Paci, 2019, Letters in Drug Design & Discovery.

env Chimeric Virus Technology for Evaluating Human Immunodeficiency Virus Susceptibility to Entry Inhibitors

C. Pannecouque, A. Vandamme, K. Van Laethem, 2003, Antimicrobial Agents and Chemotherapy.

The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition

C. Pannecouque, J. Balzarini, A. Karlsson, 2016, PloS one.

Silibinin phosphodiester glyco-conjugates: Synthesis, redox behaviour and biological investigations.

C. Pannecouque, R. Agarwal, M. Iuliano, 2018, Bioorganic chemistry.

Ceramide involvement in apoptosis and apoptotic diseases.

J. Winderickx, C. Pannecouque, B. Cammue, 2006, Mini reviews in medicinal chemistry.

Inhibition of HIV-1 RT activity by a new series of 3-(1,3,4-thiadiazol-2-yl)thiazolidin-4-one derivatives.

C. Pannecouque, R. Gitto, Laura Ielo, 2020, Bioorganic & medicinal chemistry.

Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel".

E. De Clercq, Dongwei Kang, C. Pannecouque, 2018, Organic & biomolecular chemistry.

1,6-Bis[(benzyloxy)methyl]uracil derivatives-Novel antivirals with activity against HIV-1 and influenza H1N1 virus.

C. Pannecouque, L. Naesens, S. Kochetkov, 2016, Bioorganic & medicinal chemistry.

In vitro evaluation of the effect of temporary removal of HIV drug pressure.

C. Pannecouque, M. Witvrouw, K. Andries, 2000, Antiviral research.

Mixed oligonucleotide analogues with an acyclic carbohydrate moiety and a N-cyanoguanidine functionality

C. Pannecouque, P. Herdewijn, J. Rozenski, 1994 .

Synthesis and Antiviral Evaluation of 3′-Substituted Thymidine Analogues Derived from 3′-Amino-3′-deoxythymidine

C. Pannecouque, P. Herdewijn, J. Balzarini, 1995 .

Nitroimidazoles Part 6. Synthesis, Structure and in Vitro anti-HIV Activity of New 5-substituted Piperazinyl-4-nitroimidazole Derivatives

E. De Clercq, C. Pannecouque, N. Al-Masoudi, 2007, Antiviral chemistry & chemotherapy.

SYNTHESIS AND BIOLOGICAL ACTIVITY OF 4-SUBSTITUTED 1-[1-(2-HYDROXYETHOXY)- METHYL-1,2,3-TRIAZOL-(4 & 5)-YLMETHYL]-1H-PYRAZOLO[3,4-d]PYRIMIDINES

E. De Clercq, C. Pannecouque, M. Witvrouw, 2001, Nucleosides, nucleotides & nucleic acids.

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME 4-SUBSTITUTED 1-[1-(4-HYDROXYBUTYL)-1,2,3-TRIAZOL-(4 & 5)-YLMETHYL]-1H-PYRAZOLO-[3,4-d]PYRIMIDINES

E. De Clercq, C. Pannecouque, M. Witvrouw, 2001, Nucleosides, nucleotides & nucleic acids.

SYNTHESIS AND ANTI-HIV ACTIVITY OF NEW MODIFIED 1,2,3-TRIAZOLE ACYCLONUCLEOSIDES

E. De Clercq, C. Pannecouque, J. Imbach, 2001, Nucleosides, nucleotides & nucleic acids.

Structure-activity relationships for dipeptide prodrugs of acyclovir: implications for prodrug design.

E. De Clercq, C. Pannecouque, R. Moreira, 2009, European journal of medicinal chemistry.

Dipeptide Derivatives of AZT: Synthesis, Chemical Stability, Activation in Human Plasma, hPEPT1 Affinity, and Antiviral Activity

C. Pannecouque, R. Moreira, C. Nielsen, 2008, ChemMedChem.

Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine

C. Pannecouque, E. Arnold, P. Herdewijn, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis, anti-HIV activity, and metabolic stability of new alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, P. Fanwick, 2005, Journal of medicinal chemistry.

Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7.

E. De Clercq, Dongwei Kang, Boshi Huang, 2020, Bioorganic & Medicinal Chemistry Letters.

Design, synthesis and anti-HIV activity of novel quinoxaline derivatives.

C. Pannecouque, H. Bhatt, B. Patel, 2016, European journal of medicinal chemistry.

Synthesis, In Vitro and In Vivo Release Kinetics, and Anti‐HIV Activity of A Sustained‐Release Prodrug (mPEG‐AZT) of 3′‐Azido‐3′‐deoxythymidine (AZT, Zidovudine)

C. Pannecouque, P. Zhan, Xinyong Liu, 2010, ChemMedChem.

Development of fluorine-substituted NH2-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors: Boosting the safety and metabolic stability

E. De Clercq, C. Pannecouque, H. Piao, 2022, Acta pharmaceutica Sinica. B.

Binding optimization through coordination chemistry: CXCR4 chemokine receptor antagonists from ultrarigid metal complexes.

E. De Clercq, C. Pannecouque, J. Greenman, 2009, Journal of the American Chemical Society.

Synthesis and anti-HIV activity of novel cyclopentenyl nucleoside analogues of 8-azapurine.

E. Uriarte, E. De Clercq, C. Pannecouque, 2006, Chemical & pharmaceutical bulletin.

Synthesis, antimycobacterial, antiviral, antimicrobial activities, and QSAR studies of nicotinic acid benzylidene hydrazide derivatives

B. Narasimhan, P. Yogeeswari, D. Sriram, 2012, Medicinal Chemistry Research.

Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems.

E. De Clercq, C. Pannecouque, M. Cushman, 2007, Journal of medicinal chemistry.

Conformationally Locked Carbocyclic Nucleosides Built on a 4′-Hydroxymethyl-3′-hydroxybicyclo[4.1.0]heptane Template. Stereoselective Synthesis and Antiviral Activity

C. Pannecouque, O. Illa, F. Busqué, 2022, The Journal of organic chemistry.

Synthesis, structure–activity relationship and antiviral activity of 3′-N,N-dimethylamino-2′,3′-dideoxythymidine and its prodrugs

E. De Clercq, C. Pannecouque, E. Clercq, 2010, European Journal of Medicinal Chemistry.

Design and synthesis of a novel series of non-nucleoside HIV-1 inhibitors bearing pyrimidine and N-substituted aromatic piperazine.

E. De Clercq, C. Pannecouque, Y. Sang, 2018, Bioorganic & medicinal chemistry letters.

Amidate Prodrugs of Deoxythreosyl Nucleoside Phosphonates as Dual Inhibitors of HIV and HBV Replication.

R. Ptak, C. Pannecouque, P. Herdewijn, 2016, Journal of medicinal chemistry.

Deoxythreosyl phosphonate nucleosides as selective anti-HIV agents.

E. De Clercq, C. Pannecouque, P. Herdewijn, 2005, Journal of the American Chemical Society.

Antiviral potential of “new” acyclic nucleoside phosphonates, the 6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines

C. Pannecouque, L. Naesens, J. Neyts, 2004 .

Synthesis and antiviral evaluation of base-modified deoxythreosyl nucleoside phosphonates.

C. Pannecouque, P. Herdewijn, Chao Liu, 2017, Organic & biomolecular chemistry.

Synthesis and in Vitro Antiviral Activities of [(Dihydrofuran‐2‐yl)oxy]methyl‐phosphonate Nucleosides with 2‐Substituted Adenine as Base

C. Pannecouque, P. Herdewijn, Fei Liu, 2015, Chemistry & biodiversity.

Modification of the length and structure of the linker of N(6)-benzyladenosine modulates its selective antiviral activity against enterovirus 71.

C. Pannecouque, J. Neyts, V. Tararov, 2016, European journal of medicinal chemistry.

New 3'-azido-3'-deoxythymidin-5'-yl O-(4-hydroxyalkyl or -alkenyl or -alkylepoxide) carbonate prodrugs: synthesis and anti-HIV evaluation.

E. De Clercq, C. Pannecouque, J. Kraus, 2001, Journal of medicinal chemistry.

New 3'-azido-3'-deoxythymidin-5'-yl O-(omega-hydroxyalkyl) carbonate prodrugs: synthesis and anti-HIV evaluation.

E. De Clercq, C. Pannecouque, F. Bihel, 2001, Journal of medicinal chemistry.

Conversion of 2′,3′‐dideoxyadenosine (ddA) and 2′,3′‐didehydro‐2′,3′‐dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus

E. De Clercq, C. Pannecouque, L. Naesens, 1997, FEBS letters.

ANTIVIRAL POTENTIAL OF A NEW GENERATION OF ACYCLIC NUCLEOSIDE PHOSPHONATES, THE 6-[2-(PHOSPHONOMETHOXY)ALKOXY]-2,4-DIAMINOPYRIMIDINES

E. De Clercq, C. Pannecouque, L. Naesens, 2005, Nucleosides, nucleotides & nucleic acids.

Discovery of novel biphenyl-substituted pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with promising oral bioavailability.

F. Chen, E. De Clercq, C. Pannecouque, 2022, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2019, Bioorganic & medicinal chemistry.

Discovery of a Tat HIV-1 Inhibitor through Computer-Aided Drug Design

C. Pannecouque, J. Sturgis, E. Clercq, 2003 .

Design, Synthesis, and Mechanism Study of Benzenesulfonamide-containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, Journal of medicinal chemistry.

Inhibition of Human Immunodeficiency Virus Type 1 Integration by Diketo Derivatives

E. De Clercq, C. Pannecouque, N. Neamati, 2002, Antimicrobial Agents and Chemotherapy.

Linker optimization of HEPT derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors: from S=O to CHOR

E. De Clercq, C. Pannecouque, Fener Chen, 2022, Chinese Chemical Letters.

A novel family of diarylpyrimidines (DAPYs) featuring a diatomic linker: Design, synthesis and anti-HIV activities.

E. De Clercq, C. Pannecouque, J. Balzarini, 2015, Bioorganic & medicinal chemistry.

Synthesis and Anti‐HIV Activity of Aryl‐2‐[(4‐cyanophenyl)amino]‐4‐pyrimidinone hydrazones as Potent Non‐nucleoside Reverse Transcriptase Inhibitors

C. Pannecouque, Xiaodong Ma, J. Balzarini, 2011, ChemMedChem.

Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs.

C. Pannecouque, Xiaodong Ma, J. Balzarini, 2011, Bioorganic & medicinal chemistry.

Lead Optimization of Diarylpyrimidines as Non‐nucleoside Inhibitors of HIV‐1 Reverse Transcriptase

C. Pannecouque, J. Balzarini, Fener Chen, 2010, ChemMedChem.

Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents.

C. Pannecouque, G. Maga, E. Clercq, 2009, Bioorganic & medicinal chemistry.

Structural Modifications of DAPY Analogues with Potent Anti‐HIV‐1 Activity

C. Pannecouque, J. Balzarini, Fener Chen, 2009, ChemMedChem.

Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains.

E. De Clercq, C. Pannecouque, G. Maga, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and anti-HIV evaluation of the novel 2-(m-chlorobenzyl)-4-substituted-7-methyl-1, 1, 3-trioxo-pyrazolo[4, 5-e] [1, 2, 4]thiadiazines

C. Pannecouque, Xinyong Liu, E. Clercq, 2006, Archives of pharmacal research.

Simultaneous RNA quantification of human and retroviral genomes reveals intact interferon signaling in HTLV-1-infected CD4+ T cell lines

C. Pannecouque, A. Vandamme, R. Khouri, 2012, Virology Journal.

1,2,4-Triazole derivatives inhibiting the human immunodeficiency virus type 1 (HIV-1) in vitro

C. Pannecouque, P. Herdewijn, M. Froeyen, 2002 .

Hybrids of delavirdine and piperdin-4-yl-aminopyrimidines (DPAPYs) as potent HIV-1 NNRTIs: Design, synthesis and biological activities.

C. Pannecouque, Haifeng Wang, Fener Chen, 2023, European journal of medicinal chemistry.

Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Journal of medicinal chemistry.

Structural modifications of diarylpyrimidines (DAPYs) as HIV-1 NNRTIs: Synthesis, anti-HIV activities and SAR.

C. Pannecouque, P. Xue, Ting Li, 2017, Bioorganic & medicinal chemistry.

Structural modification of diarylpyrimidine derivatives as HIV-1 reverse transcriptase inhibitors

E. De Clercq, C. Pannecouque, J. Balzarini, 2014, Medicinal Chemistry Research.

Synthesis, biological evaluation and molecular modeling of 4,6-diarylpyrimidines and diarylbenzenes as novel non-nucleosides HIV-1 reverse transcriptase inhibitors.

Sergio R. Ribone, C. Pannecouque, W. Dehaen, 2012, European journal of medicinal chemistry.

Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs.

E. De Clercq, C. Pannecouque, Xiaodong Ma, 2011, Bioorganic & medicinal chemistry.

Structural Investigation of the Naphthyridone Scaffold: Identification of a 1,6‐Naphthyridone Derivative with Potent and Selective Anti‐HIV Activity

C. Pannecouque, D. Daelemans, S. Sabatini, 2011, ChemMedChem.

Structure modifications of 6-aminoquinolones with potent anti-HIV activity.

E. De Clercq, C. Pannecouque, M. Palumbo, 2004, Journal of medicinal chemistry.

Design, Synthesis, and Evaluation of WC5 Analogues as Inhibitors of Human Cytomegalovirus Immediate‐Early 2 Protein, a Promising Target for Anti‐HCMV Treatment

C. Pannecouque, G. Palù, A. Loregian, 2013, ChemMedChem.

Searching for novel N1-substituted benzimidazol-2-ones as non-nucleoside HIV-1 RT inhibitors.

C. Pannecouque, S. Ferro, L. De Luca, 2017, Bioorganic & medicinal chemistry.

Scaffold hopping: exploration of acetanilide-containing uracil analogues as potential NNRTIs.

A. V. Ivanov, C. Pannecouque, J. Balzarini, 2015, Bioorganic & medicinal chemistry.

Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on crystallographic overlays.

Peng Zhan, Jan Balzarini, Christophe Pannecouque, 2014, Bioorganic & medicinal chemistry.

Synthesis and antiproliferative evaluation of novel 2-(4H-1,2,4-triazole-3-ylthio)acetamide derivatives as inducers of apoptosis in cancer cells.

E. De Clercq, C. Pannecouque, Esra Tatar, 2016, European journal of medicinal chemistry.

Synthesis and Anti‐HIV Activity of 4‐(Naphthalen‐1‐yl)‐1,2,5‐thiadiazol‐3‐hydroxyl Derivatives

E. De Clercq, C. Pannecouque, P. Zhan, 2014, Chemical biology & drug design.

Synthesis and Anti‐HIV Activity Evaluation of Novel 2,4‐Disubstituted 7‐Methyl‐1,1,3‐trioxo‐2,4‐dihydro‐pyrazolo‐[4,5‐e][1,2]thiadiazines

E. De Clercq, C. Pannecouque, P. Zhan, 2008, Archiv der Pharmazie.

Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Chemical Society reviews.

Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends.

Peng Zhan, Christophe Pannecouque, E. De Clercq, 2016, Journal of medicinal chemistry.

Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

Zengjun Fang, C. Pannecouque, P. Zhan, 2009, Bioorganic & medicinal chemistry.

Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.

E. De Clercq, C. Pannecouque, M. Witvrouw, 2002, Farmaco.

Synthesis and Anti-HIV Evaluation of Novel 1,2,4-triazole Derivatives as Potential Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

C. Pannecouque, P. Zhan, Xinyong Liu, 2012 .

A microwave-assisted diastereoselective multicomponent reaction to access dibenzo[c,e]azepinones: synthesis and biological evaluation.

C. Pannecouque, J. Balzarini, E. V. Van der Eycken, 2011, The Journal of organic chemistry.

An Efficient Synthesis of a Hydroxyethylamine (HEA) Isostere and Its α‐Aminophosphonate and Phosphoramidate Derivatives as Potential Anti‐HIV Agents

C. Pannecouque, A. Bhattacharya, Kalpeshkumar C. Rana, 2012, ChemMedChem.

Straightforward synthesis of triazoloacyclonucleotide phosphonates as potential HCV inhibitors.

C. Pannecouque, J. Neyts, M. Smietana, 2010, Bioorganic & Medicinal Chemistry Letters.

Hybrid chemistry. Part 4: Discovery of etravirine-VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, D. Daelemans, 2015, Bioorganic & medicinal chemistry.

Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors.

Peng Zhan, Xuwang Chen, Christophe Pannecouque, 2012, Bioorganic & medicinal chemistry.

Improved and rapid synthesis of new coumarinyl chalcone derivatives and their antiviral activity

Christophe Pannecouque, C. Pannecouque, Anamik Shah, 2007 .

Design, synthesis, antimicrobial activity and anti-HIV activity evaluation of novel hybrid quinazoline–triazine derivatives

E. De Clercq, C. Pannecouque, K. Chikhalia, 2014, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and Evaluation of Novel 4‐Substituted Styryl Quinazolines as Potential Antimicrobial Agents

Amit C. Patel, E. De Clercq, C. Pannecouque, 2012, Archiv der Pharmazie.

Synthesis and biological activity of some 4-substituted 1-[1-(2,3-dihydroxy-1-propoxy)methyl-1,2,3-triazol-(4 & 5)-ylmethyl]-1H-pyrazolo[3,4-d]pyrimidines.

Myriam Witvrouw, Jean-Jacques Vasseur, Christophe Pannecouque, 2002, Farmaco.

Synthesis and Studies of New 2‐(Coumarin‐4‐yloxy)‐4,6‐(substituted)‐s‐Triazine Derivatives as Potential Anti‐HIV Agents

Christophe Pannecouque, E. De Clercq, C. Pannecouque, 2009, Archiv der Pharmazie.

Non‐Nucleoside HIV‐1 Reverse Transcriptase Inhibitors. Part 13

C. Pannecouque, J. Balzarini, Fener Chen, 2009, Chemistry & biodiversity.

Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: structural modulations of diaryltriazines with potent anti-HIV activity.

Jan Balzarini, Christophe Pannecouque, E. De Clercq, 2008, European journal of medicinal chemistry.

Synthesis of novel PETT analogues: 3,4-dimethoxy phenyl ethyl 1,3,5-triazinyl thiourea derivatives and their antibacterial and anti-HIV studies

C. Pannecouque, E. Clercq, K. Chikhalia, 2007 .

Anti-influenza virus activity and structure–activity relationship of aglycoristocetin derivatives with cyclobutenedione carrying hydrophobic chains

J. Jekő,, C. Pannecouque, L. Naesens, 2009, Antiviral Research.

Synthesis and anti-hIV activity of 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazole structurally-related 1,2-substituted benzimidazoles.

E. De Clercq, C. Pannecouque, A. Chimirri, 2002, Farmaco.

Pyridazines 92. Synthesis of dialkyldipyridazinodiazepinones as potential HIV-1 reverse transcriptase inhibitors

C. Pannecouque, E. Clercq, M. Witvrouw, 2001 .

New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.

E. De Clercq, C. Pannecouque, M. Witvrouw, 2002, Bioorganic & medicinal chemistry letters.

Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action.

E. De Clercq, C. Pannecouque, J. Balzarini, 2005, The Journal of antimicrobial chemotherapy.

Zinc(II) complexes of constrained antiviral macrocycles.

P. Sadler, E. De Clercq, C. Pannecouque, 2012, Dalton transactions.

Synthesis and Biological Activity of Novel 1H,3H-Thiazolo[3,4-a]Benzimidazoles: Non-nucleoside Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors

E. De Clercq, C. Pannecouque, J. Balzarini, 1999, Antiviral chemistry & chemotherapy.

Novel inhibitors of HIV-1 integration.

C. Pannecouque, J. Vercammen, Z. Debyser, 2004, Current drug metabolism.

Design, synthesis and preliminary antiviral screening of new N-phenylpyrazole and dihydroisoxazole derivatives

C. Pannecouque, J. Balzarini, G. Andrei, 2010, Medicinal Chemistry Research.

Synthesis and antiviral activity of new pyrazole and thiazole derivatives.

C. Pannecouque, J. Balzarini, G. Andrei, 2009, European journal of medicinal chemistry.

Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings.

E. De Clercq, C. Pannecouque, Zhigang Zhou, 2006, Bioorganic & medicinal chemistry.

A 1,8-naphthyridone derivative targets the HIV-1 Tat-mediated transcription and potently inhibits the HIV-1 replication.

C. Pannecouque, A. Knezevich, A. Marcello, 2010, Journal of medicinal chemistry.

Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents.

Ravindra K Rawal, Christophe Pannecouque, E. De Clercq, 2007, Bioorganic & Medicinal Chemistry.

Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents.

Jan Balzarini, Angela Rao, Maria Zappalà, 2004, Farmaco.

Computer‐Aided Design, Synthesis and Validation of 2‐Phenylquinazolinone Fragments as CDK9 Inhibitors with Anti‐HIV‐1 Tat‐Mediated Transcription Activity

C. Pannecouque, A. Marcello, S. Sabatini, 2013, ChemMedChem.

Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide.

E. Novellino, C. Pannecouque, A. Coluccia, 2011, Journal of medicinal chemistry.

New synthesis and anti-HIV and antiviral properties of 3-arylsulfonyl derivatives of 4-ydroxycoumarin and 4-hydroxyquinolone

C. Pannecouque, E. Clercq, R. Kurkjian, 2008, Pharmaceutical Chemistry Journal.

Anti-HIV, antimycobacterial and antimicrobial studies of newly synthesized 1,2,4-triazole clubbed benzothiazoles

C. Pannecouque, E. Clercq, N. Patel, 2013, Medicinal Chemistry Research.

Some Hydrazones of 2‐Aroylamino‐3‐methylbutanohydrazide: Synthesis, Molecular Modeling Studies, and Identification as Stereoselective Inhibitors of HIV‐1

E. De Clercq, C. Pannecouque, Neerja Kaushik-Basu, 2013, Archiv der Pharmazie.

Design, Synthesis and Structure—Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Molecules.

Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, European journal of medicinal chemistry.

Synthesis of (Z) and (E) α-Alkenyl Phosphonic Acid Derivatives of Purines and Pyrimidines.

C. Pannecouque, J. Balzarini, E. Clercq, 1998 .

Replacement of the metabolically labile methyl esters in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors with isoxazolone, isoxazole, oxazolone, or cyano substituents.

E. De Clercq, C. Pannecouque, M. Cushman, 2006, Journal of medicinal chemistry.

5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.

E. De Clercq, C. Pannecouque, P. Herdewijn, 1991, Journal of medicinal chemistry.

Synthesis and biological evaluation of alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors that possess increased hydrolytic stability.

C. Pannecouque, E. Clercq, M. Cushman, 2007, Journal of medicinal chemistry.

Design, synthesis, anti-HIV activities, and metabolic stabilities of alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, M. Cushman, 2004, Journal of medicinal chemistry.

Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer's disease.

C. Pannecouque, A. Van Aerschot, S. Wera, 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A new vinyl selenone-based domino approach to spirocyclopropyl oxindoles endowed with anti-HIV RT activity.

C. Pannecouque, E. Tramontano, O. Tabarrini, 2016, Organic & biomolecular chemistry.

Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.

E. De Clercq, C. Pannecouque, F. Şahin, 2009, European journal of medicinal chemistry.

Synthesis and biological evaluation of novel 2-(substituted phenylaminocarbonylmethylthio)-6-(2,6-dichlorobenzyl)-pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs.

C. Pannecouque, Xinyong Liu, E. Clercq, 2009, Bioorganic & medicinal chemistry.

Heterocyclic rimantadine analogues with antiviral activity.

E. De Clercq, C. Pannecouque, J. Neyts, 2003, Bioorganic & medicinal chemistry.

Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-acetamides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, Zengjun Fang, C. Pannecouque, 2009, European journal of medicinal chemistry.

Novel 1,2,3-thiadiazole derivatives as HIV-1 NNRTIs with improved potency: Synthesis and preliminary SAR studies.

Zengjun Fang, C. Pannecouque, P. Zhan, 2009, Bioorganic & Medicinal Chemistry.

1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, P. Zhan, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and anti-HIV Activity of New Fused Chromene Derivatives Derived from 2-Amino-4-(1-naphthyl)-5-oxo-4H,5H-pyrano[3,2- c]chromene-3-carbonitrile

C. Pannecouque, P. Langer, A. Spannenberg, 2013 .

Sodium and potassium benzeneazophosphonate complexes with crown ethers: solid-state microwave synthesis, characterization and biological activity

C. Pannecouque, J. Balzarini, E. Clercq, 2009 .

Structure-activity relationship study on anti-HIV 6-desfluoroquinolones.

C. Pannecouque, J. Balzarini, D. Daelemans, 2008, Journal of medicinal chemistry.

Broad-Spectrum Antiviral Activity and Mechanism of Antiviral Action of the Fluoroquinolone Derivative K-12

E. De Clercq, C. Pannecouque, A. Vandamme, 1998, Antiviral chemistry & chemotherapy.

Discovery of HIV‐1 Integrase Inhibitors: Pharmacophore Mapping, Virtual Screening, Molecular Docking, Synthesis, and Biological Evaluation

C. Pannecouque, H. Bhatt, P. Patel, 2014, Chemical biology & drug design.

Synthesis and in vitro evaluation of S-acyl-3-thiopropyl prodrugs of Foscarnet.

C. Pannecouque, J. Montero, A. Morère, 2004, Bioorganic & medicinal chemistry.

Synthesis and primary antiviral activity evaluation of 3-hydrazono-5-nitro-2-indolinone derivatives

C. Pannecouque, J. Neyts, E. Clercq, 2005 .

Design and synthesis of 2-(2,6-dibromophenyl)-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents.

Ravindra K Rawal, Christophe Pannecouque, E. De Clercq, 2008, European journal of medicinal chemistry.

Synthesis, crystal structure, anti-HIV, and antiproliferative activity of new oxadiazole and thiazole analogs

C. Pannecouque, S. Hameed, T. Akhtar, 2016, Medicinal Chemistry Research.

Antiviral activity against human immunodeficiency virus type 1 (HIV‐1) and type 2 (HIV‐2) of ethnobotanically selected Ethiopian medicinal plants

C. Pannecouque, M. Witvrouw, K. Asres, 2001, Phytotherapy research : PTR.

Synthesis and Evaluation of Novel 4‐Substituted Styryl Quinazolines as Potential Antimicrobial Agents.

Amit C. Patel, C. Pannecouque, E. Clercq, 2013 .

N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase

A. V. Ivanov, C. Pannecouque, J. Balzarini, 2013, Bioorganic & Medicinal Chemistry.

Synthesis and biological evaluation of 2,3-diaryl substituted-1,3-thiazolidin-4-ones as anti-HIV agents.

Ravindra K Rawal, Christophe Pannecouque, E. De Clercq, 2007, Medicinal chemistry (Shariqah (United Arab Emirates)).

Design, synthesis, and evaluation of 2-aryl-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents.

Ravindra K Rawal, Christophe Pannecouque, E. De Clercq, 2007, Bioorganic & medicinal chemistry.

2-(2,6-Dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, J. Balzarini, 2004, Antiviral research.

Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-ones.

Angela Rao, Maria Zappalà, Pietro Monforte, 2003, Farmaco.

Synthesis and Screening for Anti-HIV Activity of Some N-Mannich Bases of Isatin Derivatives

P. Yogeeswari, D. Sriram, E. De Clercq, 1999, Chemotherapy.

Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy.

E. De Clercq, C. Pannecouque, J. Balzarini, 2010, Bioorganic & medicinal chemistry.

Antimicrobial, anti-TB, anticancer and anti-HIV evaluation of new s-triazine-based heterocycles.

E. De Clercq, C. Pannecouque, P. Kumari, 2012, Future Medicinal Chemistry.

1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity

C. Pannecouque, E. Tramontano, S. Sabatini, 2020, Molecules.

Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors.

C. Pannecouque, J. Balzarini, E. Clercq, 2010, Bioorganic & medicinal chemistry.

Design, synthesis, and biological evaluation of piperidinyl‐substituted [1,2,4]triazolo[1,5‐a]pyrimidine derivatives as potential anti‐HIV‐1 agents with reduced cytotoxicity

E. De Clercq, Dongwei Kang, Boshi Huang, 2020, Chemical biology & drug design.

Synthesis, crystal structure, anti-HIV, and antiproliferative activity of new pyrazolylthiazole derivatives

C. Pannecouque, S. Hameed, N. Al-Masoudi, 2017, Medicinal Chemistry Research.

Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs.

Peng Zhan, Ye Tian, Xuwang Chen, 2012, Bioorganic & medicinal chemistry letters.

N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action.

E. De Clercq, C. Pannecouque, P. Herdewijn, 2003, Journal of medicinal chemistry.

Sydnone Sulfonamide Derivatives as Antibacterial, Antifungal, Antiproliferative and Anti-HIV Agents

E. De Clercq, C. Pannecouque, K. Patel, 2014, Pharmaceutical Chemistry Journal.

Synthesis and anti-HIV Activity of New Fused Chromene Derivatives Derived from 2-Amino-4-(1-naphthyl)-5-oxo-4H,5H-pyrano [3,2-c]chromene-3-carbonitrile.

C. Pannecouque, P. Langer, A. Spannenberg, 2013 .

Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N, E138K Mutants, and Pharmacokinetic Profiles.

E. De Clercq, C. Pannecouque, Fener Chen, 2020, ACS infectious diseases.

Synthesis and anti-HIV Activity of New Benzimidazole, Benzothiazole and Carbohyrazide Derivatives of the anti-Inflammatory Drug Indomethacin

C. Pannecouque, N. Al-Masoudi, Nadhir N. A. Jafar, 2011 .

Synthesis and biological evaluation of some new 1,3,4-thiadiazole and 1,2,4-triazole derivatives from L-methionine as antituberculosis and antiviral agents

C. Pannecouque, F. Şahin, T. Kocagöz, 2015 .

Anti-HIV, antimycobacterial and antimicrobial studies of newly synthesized 1,2,4-triazole clubbed benzothiazoles

E. De Clercq, C. Pannecouque, N. Patel, 2013, Medicinal Chemistry Research.

Synthesis of novel derivatives of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole as potential HIV-1 NNRTIs.

E. De Clercq, C. Pannecouque, Xinyong Liu, 2007, Molecules.

1,2,3-Selenadiazole thioacetanilides: synthesis and anti-HIV activity evaluation.

E. De Clercq, Zengjun Fang, C. Pannecouque, 2009, Bioorganic & medicinal chemistry.

Non-nucleoside reverse transcriptase inhibitors (Part 18): synthesis and anti-HIV activity of 4-allylamino or 4-azido substituted diaryltriazines.

E. De Clercq, C. Pannecouque, J. Balzarini, 2009, Yao xue xue bao = Acta pharmaceutica Sinica.

Synthesis of novel biologically active methylene derivatives of sydnones

E. De Clercq, C. Pannecouque, C. Supuran, 2013, Medicinal Chemistry Research.

Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives.

Peng Zhan, Ye Tian, Christophe Pannecouque, 2014, Bioorganic & medicinal chemistry.

Probing key coordination interactions: configurationally restricted metal activated CXCR4 antagonists.

E. De Clercq, C. Pannecouque, S. Archibald, 2007, Dalton transactions.

Synthesis and biological evaluation of novel 5-alkyl-2-arylthio-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Peng Zhan, Jing Zhang, Christophe Pannecouque, 2011, Bioorganic & medicinal chemistry.

Arylazolyl(azinyl)thioacetanilides. Part 16: Structure-based bioisosterism design, synthesis and biological evaluation of novel pyrimidinylthioacetanilides as potent HIV-1 inhibitors.

Peng Zhan, Jan Balzarini, Christophe Pannecouque, 2014, Bioorganic & medicinal chemistry.

Synthesis and anti‐HIV Activity of 1‐(2,6‐Difluorophenyl)‐1H,3H‐thiazolo[3,4‐a]benzimidazole Structurally‐Related 1,2‐Substituted Benzimidazoles.

C. Pannecouque, E. Clercq, A. Chimirri, 2003 .

Synthesis, Structure and in Vitro Anti-Human Immunodeficiency virus Activity of Novel 3-Methyl-1H,3H-Thiazolo[3,4-a]Benzimidazoles

E. De Clercq, C. Pannecouque, M. Witvrouw, 1998, Antiviral chemistry & chemotherapy.

Synthesis, enzymatic stability and physicochemical properties of oligonucleotides containing a N-cyanoguanidine linkage.

C. Pannecouque, P. Herdewijn, R. Busson, 1994 .

Novel Human Immunodeficiency Virus (HIV) Inhibitors That Have a Dual Mode of Anti-HIV Action

E. De Clercq, C. Pannecouque, J. Balzarini, 2003, Antimicrobial Agents and Chemotherapy.

Inhibition of Human Immunodeficiency Virus by a New Class of Pyridine Oxide Derivatives

E. De Clercq, C. Pannecouque, J. Balzarini, 2003, Antimicrobial Agents and Chemotherapy.

Pyridine oxide derivatives: structure-activity relationship for inhibition of human immunodeficiency virus and cytomegalovirus replication in cell culture

C. Pannecouque, J. Balzarini, E. Clercq, 2002 .

Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, G. Maga, 2010, Bioorganic & medicinal chemistry.

Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.

Jan Balzarini, Angela Rao, Maria Zappalà, 2005, Journal of medicinal chemistry.

Anti‐HIV Activity of Thiosemicarbazone and Semicarbazone Derivatives of (±)‐3‐Menthone

E. De Clercq, C. Pannecouque, M. Witvrouw, 2002, Archiv der Pharmazie.

Design and synthesis of N₁-aryl-benzimidazoles 2-substituted as novel HIV-1 non-nucleoside reverse transcriptase inhibitors.

C. Pannecouque, J. Balzarini, S. Ferro, 2014, Bioorganic & medicinal chemistry.

Design and Synthesis of DiselenoBisBenzamides (DISeBAs) as Nucleocapsid Protein 7 (NCp7) Inhibitors with anti-HIV Activity.

C. Pannecouque, O. Tabarrini, L. Bagnoli, 2015, Journal of medicinal chemistry.

Synthesis and anti-HIV activity of cosalane analogues incorporating two dichlorodisalicylmethane pharmacophore fragments.

E. De Clercq, C. Pannecouque, E. Clercq, 2001, Bioorganic & medicinal chemistry.

Synthesis and anti‐HIV activity of new 2‐thiolumazine and 2‐thiouracil metal complexes

C. Pannecouque, N. Al-Masoudi, B. A. Saleh, 2011 .

Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2019, Organic & biomolecular chemistry.

Nitroimidazoles Part 7. Synthesis and Anti-HIV Activity of New 4-Nitroimidazole Derivatives

C. Pannecouque, W. Pfleiderer, Najim A. Masoudi, 2012 .

Synthesis of (Z) and (E) α-Alkenyl Phosphonic Acid Derivatives of Purines and Pyrimidines.

C. Pannecouque, J. Balzarini, E. Clercq, 1998 .

Nonnucleoside HIV-1 reverse transcriptase inhibitors: Part I. Synthesis and structure-activity relationship of 1-alkoxymethyl-5-alkyl-6-naphthylmethyl uracils as HEPT analogues.

E. De Clercq, C. Pannecouque, J. Balzarini, 2003, Chemical & pharmaceutical bulletin.

Pyridazines. Part 92. Synthesis of Dialkyldipyridazinodiazepinones as Potential HIV-1 Reverse Transcriptase Inhibitors.

C. Pannecouque, E. Clercq, M. Witvrouw, 2010 .

SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus

E. De Clercq, C. Pannecouque, A. Vandamme, 1997, Antimicrobial agents and chemotherapy.

Configurationally restricted bismacrocyclic CXCR4 receptor antagonists.

Stephen J Archibald, Peter J Sadler, Christophe Pannecouque, 2006, Journal of medicinal chemistry.

First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication.

E. De Clercq, C. Pannecouque, C. Len, 2005, Journal of medicinal chemistry.

Dimer disruption and monomer sequestration by alkyl tripeptides are successful strategies for inhibiting wild-type and multidrug-resistant mutated HIV-1 proteases.

E. De Clercq, C. Pannecouque, L. Bannwarth, 2009, Biochemistry.

Amino acid derivatives. Part 5. Synthesis and anti-HIV activity of new sebacoyl precursor derived thioureido-amino acid and phthalimide derivatives

C. Pannecouque, N. Al-Masoudi, Nahed H. Al-Haidery, 2010 .

Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds.

E. De Clercq, C. Pannecouque, J. Balzarini, 2008, Bioorganic & medicinal chemistry.

Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound.

E. De Clercq, C. Pannecouque, J. Balzarini, 2008, Bioorganic & medicinal chemistry letters.

1,2,3‐Thiadiazole Thioacetanilides. Part 2

C. Pannecouque, P. Zhan, Zhen-Yu Li, 2010, Chemistry & biodiversity.

Potent anti-HIV (type 1 and type 2) activity of polyoxometalates: structure-activity relationship and mechanism of action.

C. Pannecouque, D. Schols, M. Witvrouw, 2000, Journal of medicinal chemistry.

Synthesis and evaluation of antiviral , antitubercular and anticancer activities of some novel thioureas derived from 4-aminobenzohydrazide hydrazones

C. Pannecouque, E. Clercq, G. Andrei, 2010 .

Amino acid derivatives. Part 6. Synthesis, in vitro antiviral activity and molecular docking study of new N-α-amino acid derivatives conjugated spacer phthalimide backbone

C. Pannecouque, E. Abood, N. Al-Masoudi, 2016, Medicinal Chemistry Research.

Synthesis and anti-HIV activity of 4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene) amino]-N(4,6-dimethyl-2-pyrimidinyl)-benzene sulfonamide and its derivatives.

C. Pannecouque, M. Witvrouw, P. Selvam, 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Synthesis and biological evaluation of new heterocyclic quinolinones as anti-parasite and anti-HIV drug candidates.

C. Pannecouque, M. Robin, N. Azas, 2009, Bioorganic & medicinal chemistry letters.

Phytochemical and biological investigations of Elaeodendron schlechteranum.

C. Pannecouque, D. Ferreira, S. Apers, 2010, Journal of ethnopharmacology.

Oxovanadium(IV) cyclam and bicyclam complexes: potential CXCR4 receptor antagonists.

P. Sadler, E. De Clercq, C. Pannecouque, 2010, Inorganic chemistry.

Susceptibility of HIV-2, Siv and Shiv to Various Anti-HIV-1 Compounds: Implications for Treatment and Postexposure Prophylaxis

W. Heneine, C. Pannecouque, E. Clercq, 2004, Antiviral therapy.

Screening of Tanzanian medicinal plants against Plasmodium falciparum and human immunodeficiency virus.

C. Pannecouque, S. Apers, N. Hermans, 2010, Planta medica.

Biologically active bisbenzylisoquinoline alkaloids from the root bark of Epinetrum villosum.

C. Pannecouque, M. Claeys, S. Apers, 2005, Journal of ethnopharmacology.

Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later

C. Pannecouque, E. Clercq, D. Daelemans, 2008, Nature Protocols.

Artemisinin Analogues as Potent Inhibitors of In Vitro Hepatitis C Virus Replication

C. Pannecouque, W. Dehaen, J. Neyts, 2013, PloS one.

Studies on anti-HIV quinolones: new insights on the C-6 position.

C. Pannecouque, D. Daelemans, S. Sabatini, 2009, Bioorganic & medicinal chemistry.

Novel In Vivo Model for the Study of Human Immunodeficiency Virus Type 1 Transcription Inhibitors: Evaluation of New 6-Desfluoroquinolone Derivatives

E. De Clercq, C. Pannecouque, E. Verbeken, 2007, Antimicrobial Agents and Chemotherapy.

2 A NOVEL IN VIVO MODEL FOR THE STUDY OF HIV-1 3 TRANSCRIPTION INHIBITORS : EVALUATION OF NEW 4 6-DESFLUOROQUINOLONE DERIVATIVES ( 6-DFQs ) 5

C. Pannecouque, E. Verbeken, J. Balzarini, 2007 .

HIV-1 transcription in vivo-1-1 2 A NOVEL IN VIVO MODEL FOR THE STUDY OF HIV-1 3 TRANSCRIPTION INHIBITORS : EVALUATION OF NEW 4 6-DESFLUOROQUINOLONE DERIVATIVES ( 6-DFQs ) 5 6 7

C. Pannecouque, E. Verbeken, J. Balzarini, 2007 .

A Novel and Efficient Approach to Discriminate between Pre- and Post-Transcription HIV Inhibitors

E. De Clercq, C. Pannecouque, G. Pavlakis, 2005, Molecular Pharmacology.

Chemical studies of essential oils of Juniperus oxycedrus ssp. badia.

E. De Clercq, C. Pannecouque, M. Witvrouw, 2002, Journal of ethnopharmacology.

Synthesis and anti-HIV activity evaluation of novel N′-arylidene-2-[1-(naphthalen-1-yl)-1H-tetrazol-5-ylthio]acetohydrazides

C. Pannecouque, P. Zhan, Xinyong Liu, 2010, Medicinal Chemistry Research.

Arylazolylthioacetanilide. Part 11: design, synthesis and biological evaluation of 1,2,4-triazole thioacetanilide derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

C. Pannecouque, P. Zhan, Xinyong Liu, 2013, Medicinal chemistry (Shariqah (United Arab Emirates)).

Discovery of novel pyridazinylthioacetamides as potent HIV-1 NNRTIs using a structure-based bioisosterism approach

Peng Zhan, Erik De Clercq, Ye Tian, 2013 .

Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach.

Peng Zhan, Erik De Clercq, Ye Tian, 2012, Bioorganic & medicinal chemistry.

Arylazolyl(azinyl)thioacetanilides. Part 10: design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors.

Peng Zhan, Jan Balzarini, Xuwang Chen, 2012, Bioorganic & medicinal chemistry.

Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents

E. De Clercq, C. Pannecouque, L. Naesens, 2012, Archives of Pharmacal Research.

Arylazolylthioacetanilide. Part 8: Design, synthesis and biological evaluation of novel 2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)-N-arylacetamides as potent HIV-1 inhibitors.

E. De Clercq, C. Pannecouque, P. Zhan, 2011, European journal of medicinal chemistry.

A second target for the peptoid Tat/transactivation response element inhibitor CGP64222: inhibition of human immunodeficiency virus replication by blocking CXC-chemokine receptor 4-mediated virus entry.

E. De Clercq, C. Pannecouque, T. Klimkait, 2000, Molecular pharmacology.

6‐[2‐Phosphonomethoxy)Alkoxy]‐2,4‐Diaminopyrimidines: A New Class of Acyclic Pyrimidine Nucleoside Phosphonates with Antiviral Activity

E. De Clercq, C. Pannecouque, L. Naesens, 2004, Nucleosides, nucleotides & nucleic acids.

Halogenated sesquiterpenes from the red alga Laurencia obtusa

C. Pannecouque, V. Roussis, E. Clercq, 2002 .

Novel 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine derivatives as non-nucleoside reverse transcriptase inhibitors that inhibit human immunodeficiency virus type 1 replication.

E. De Clercq, C. Pannecouque, J. Balzarini, 1998, Journal of medicinal chemistry.

Synthesis, antimycobacterial, antiviral, antimicrobial activities, and QSAR studies of isonicotinic acid-1-(substituted phenyl)-ethylidene/cycloheptylidene hydrazides

B. Narasimhan, P. Yogeeswari, D. Sriram, 2012, Medicinal Chemistry Research.

Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy

E. De Clercq, C. Pannecouque, Fener Chen, 2020, Molecules.

Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV‐1 RNase H inhibitors

Peng Zhan, Jacob Kongsted, Luis Menéndez-Arias, 2019, Chemical biology & drug design.

From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors

C. Pannecouque, E. Tramontano, S. Sabatini, 2018, Journal of enzyme inhibition and medicinal chemistry.

Studies on Cycloheptathiophene‐3‐carboxamide Derivatives as Allosteric HIV‐1 Ribonuclease H Inhibitors

C. Pannecouque, E. Tramontano, S. Sabatini, 2016, ChemMedChem.

Synthesis, and prediction of molecular properties and antimicrobial activity of some acylhydrazones derived from $N$-(arylsulfonyl)methionine

C. Pannecouque, E. Clercq, Esra Tatar, 2016 .

Cell-dependent interference of a series of new 6-aminoquinolone derivatives with viral (HIV/CMV) transactivation.

E. De Clercq, C. Pannecouque, J. Balzarini, 2005, The Journal of antimicrobial chemotherapy.

First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain.

E. De Clercq, Dongwei Kang, Boshi Huang, 2018, Bioorganic & medicinal chemistry letters.

5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase.

Peng Zhan, Xiao Ding, Luis Menéndez-Arias, 2018, European journal of medicinal chemistry.

Molecular design opportunities presented by solvent‐exposed regions of target proteins

Peng Zhan, Erik De Clercq, Yuning Song, 2019, Medicinal research reviews.

Discovery of Novel Pyridine-Dimethyl-Phenyl-DAPY Hybrids by Molecular Fusing of Methyl-Pyrimidine-DAPYs and Difluoro-Pyridinyl-DAPYs: Improving the Druggability toward High Inhibitory Activity, Solubility, Safety, and PK.

E. De Clercq, C. Pannecouque, Li Ding, 2022, Journal of medicinal chemistry.

Design, synthesis, and antiviral evaluation of novel hydrazone‐substituted thiophene[3,2‐d]pyrimidine derivatives as potent human immunodeficiency virus‐1 inhibitors

E. De Clercq, Dongwei Kang, C. Pannecouque, 2018, Chemical biology & drug design.

Nonnucleoside HIV-1 reverse-transcriptase inhibitors, part 5. Synthesis and anti-HIV-1 activity of novel 6-naphthylthio HEPT analogues.

E. De Clercq, C. Pannecouque, J. Balzarini, 2005, Chemical & pharmaceutical bulletin.

Synthesis, Biological Activity, Pharmacokinetic Properties and Molecular Modelling Studies of Novel 1H,3H-Oxazolo[3,4-a]Benzimidazoles: Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

E. De Clercq, C. Pannecouque, G. De Sarro, 2001, Antiviral chemistry & chemotherapy.

Design, Synthesis, and Biological Evaluation of Novel Benzoyl Diarylamine/ether Derivatives as Potential Anti‐HIV‐1 Agents

E. De Clercq, Lingzi Zhang, Huiqing Liu, 2015, Chemical biology & drug design.

SYNTHESIS OF N 6-ALKYLATED ADENOSINE DERIVATIVES

C. Pannecouque, P. Herdewijn, J. Rozenski, 1996 .

Antiretrovirus Activity of a Novel Class of Acyclic Pyrimidine Nucleoside Phosphonates

E. De Clercq, C. Pannecouque, C. Perno, 2002, Antimicrobial Agents and Chemotherapy.

Design, Synthesis, and SAR of Naphthyl‐Substituted Diarylpyrimidines as Non‐Nucleoside Inhibitors of HIV‐1 Reverse Transcriptase

C. Pannecouque, J. Balzarini, Fener Chen, 2009, ChemMedChem.

Synthesis and Antiviral Activity of 1,3-Disubstituted Uracils against HIV-1 and HCMV

E. De Clercq, C. Pannecouque, J. Balzarini, 2003, Antiviral chemistry & chemotherapy.

1,1,3-Trioxo-2H,4H-Thieno[3,4-e][1,2,4]Thiadiazine (TTD) Derivatives: a New Class of Nonnucleoside Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Inhibitors with Anti-HIV-1 Activity

R. Esnouf, E. De Clercq, C. Pannecouque, 1998, Antimicrobial Agents and Chemotherapy.

Hydroxy fatty acids for the delivery of dideoxynucleosides as anti-HIV agents.

C. Pannecouque, P. Herdewijn, E. Lescrinier, 2014, Bioorganic & Medicinal Chemistry Letters.

Dimeric building blocks with N-cyanoguanidine linkage for oligonucleotide synthesis

C. Pannecouque, P. Herdewijn, A. Aerschot, 1992 .

Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI mice

E. De Clercq, C. Pannecouque, J. Balzarini, 1997, Antimicrobial agents and chemotherapy.

Dimeric Building Blocks with N-Cyanoguanidine Linkage for Oligonucleotide Synthesis.

C. Pannecouque, P. Herdewijn, A. Aerschot, 1993 .

New AZT Analogues Having 5′-Alkylsulfonyl Groups: Synthesis and Anti-HIV Activity

E. De Clercq, C. Pannecouque, N. Al-Masoudi, 2007, Nucleosides, Nucleotides & Nucleic Acids.

Microwave-Assisted Synthesis and Anti-HIV Activity of New Acyclic C-Nucleosides of 3-(D-Ribo-Tetritol-1-yl)-5-Mercapto-1,2,4-Triazoles. Part 1

C. Pannecouque, E. Clercq, N. Al-Masoudi, 2008, Nucleosides, nucleotides & nucleic acids.

Synthesis and anti-HIV activity of a bile acid analog of cosalane

C. Pannecouque, E. Clercq, M. Witvrouw, 2001 .

Synthesis, antimycobacterial, antiviral, antimicrobial activity and QSAR studies of N(2)-acyl isonicotinic acid hydrazide derivatives.

B. Narasimhan, P. Yogeeswari, D. Sriram, 2012, Medicinal chemistry (Shariqah (United Arab Emirates)).

Structure-directed linker optimization of novel HEPTs as non-nucleoside inhibitors of HIV-1 reverse transcriptase.

F. Chen, E. De Clercq, C. Pannecouque, 2023, Bioorganic chemistry.

2′-Deoxyuridines with a 5-Heteroaromatic Substituent: Synthesis and Biological Evaluation

E. De Clercq, C. Pannecouque, P. Herdewijn, 1995 .

3-Benzamido, ureido and thioureidoimidazo[1,2-a]pyridine derivatives as potential antiviral agents.

E. De Clercq, C. Pannecouque, A. Kherbeche, 2001, Chemical & pharmaceutical bulletin.

Synthesis, crystal structure, anti-HIV, and antiproliferative activity of new oxadiazole and thiazole analogs

C. Pannecouque, S. Hameed, T. Akhtar, 2016, Medicinal Chemistry Research.

Synthesis of N6‐Alkylated Adenosine Derivatives.

C. Pannecouque, P. Herdewijn, J. Rozenski, 1997 .

Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: synthesis, biological investigation and molecular modeling studies.

E. De Clercq, C. Pannecouque, J. Balzarini, 2013, Bioorganic & Medicinal Chemistry.

Chemoenzymatic Syntheses of Homo‐ and Heterodimers of AZT and d4T, and Evaluation of Their Anti‐HIV Activity

E. De Clercq, C. Pannecouque, J. Vasseur, 2004, Nucleosides, nucleotides & nucleic acids.

Novel indolylarylsulfone derivatives as covalent HIV-1 reverse transcriptase inhibitors specifically targeting the drug-resistant mutant Y181C.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase.

E. De Clercq, C. Pannecouque, P. Zhan, 2019, Bioorganic & medicinal chemistry.

1-Hydroxypyrido[2,3-d]pyrimidin-2(1H)-ones as novel selective HIV integrase inhibitors obtained via privileged substructure-based compound libraries.

Lingzi Zhang, C. Pannecouque, P. Zhan, 2017, Bioorganic & medicinal chemistry.

Prevalence and Characteristics of Multinucleoside-Resistant Human Immunodeficiency Virus Type 1 among European Patients Receiving Combinations of Nucleoside Analogues

E. De Clercq, C. Pannecouque, B. Clotet, 2000, Antimicrobial Agents and Chemotherapy.

Synthesis and Biological Evaluation of 6‐Substituted 5‐Alkyl‐2‐(phenylaminocarbonylmethylthio)pyrimidin‐4(3H)‐ones as Potent HIV‐1 NNRTIs

C. Pannecouque, Xinyong Liu, Zhenyu Li, 2011, ChemMedChem.

Synthesis and anti-HIV activity evaluation of 1-[(alkenyl or alkynyl or alkyloxy)methyl]-5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, J. Balzarini, 2007, European journal of medicinal chemistry.

Anti-HIV-1 Activity of Benzothiadiazine Dioxide

E. De Clercq, C. Pannecouque, C. Pérez, 2001, Antiviral chemistry & chemotherapy.

New AZT Analogues Having 5′-Alkylsulfonyl Groups: Synthesis and anti-HIV Activity.

C. Pannecouque, E. Clercq, N. Al-Masoudi, 2007 .

Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle.

E. De Clercq, C. Pannecouque, E. Clercq, 2000, Molecular pharmacology.

Synthesis and an Antiviral Activity Evaluation of Nucleoside 5′-O-(N-acyl) Phosphoramidates

W. Stec, C. Pannecouque, J. Balzarini, 2011, Antiviral chemistry & chemotherapy.

Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs

E. De Clercq, Dongwei Kang, Boshi Huang, 2019, Acta pharmaceutica Sinica. B.

Synthesis, drug release and anti-HIV activity of a series of PEGylated zidovudine conjugates.

E. De Clercq, C. Pannecouque, P. Zhan, 2012, International journal of biological macromolecules.

Anti-HIV Activity Of Some Mannich Bases Of Isatin Derivatives

D. Sriram, C. Pannecouque, E. Clercq, 1998 .

Phase I/II dose escalation and randomized withdrawal study with add-on azodicarbonamide in patients failing on current antiretroviral therapy

C. Pannecouque, F. Goebel, E. Clercq, 2001, AIDS.

Antiviral Activity of 3-(3,5-Dimethylbenzyl)Uracil Derivatives Against Hiv-1 and HCMV

E. De Clercq, C. Pannecouque, J. Balzarini, 2007, Nucleosides, nucleotides & nucleic acids.

Activity of non-nucleoside reverse transcriptase inhibitors against HIV-2 and SIV.

C. Pannecouque, A. Vandamme, K. Van Laethem, 1999, AIDS.

Synthesis and anti-HIV evaluation of novel 1,3-disubstituted thieno[3,2-c][1,2,6]thiadiazin-4(3H)-one 2,2-dioxides(TTDDs).

E. De Clercq, C. Pannecouque, Xinyong Liu, 2008, Bioorganic & medicinal chemistry.

Erratum to “Are 5′-O-Carbamate-2′,3′-dideoxythiacytidine new anti-HIV and anti-HBV nucleoside drugs or prodrugs?”[Bioorg. Med. Chem. Lett. 13 (2003) 2459] ☆

C. Pannecouque, J. Kraus, D. Dormont, 2003 .

Are 5'-O-carbamate-2',3'-dideoxythiacytidine new anti-HIV and anti-HBV nucleoside drugs or prodrugs?

E. De Clercq, C. Pannecouque, J. Kraus, 2003, Bioorganic & medicinal chemistry letters.

SRR-SB 3 , a Disulfide-Containing Macrolide That Inhibits a Late Stage of the Replicative Cycle of Human Immunodeficiency Virus

C. Pannecouque, A. Vandamme, J. Balzarini, 1997 .

Antiretroviral activity of semisynthetic derivatives of glycopeptide antibiotics.

E. De Clercq, C. Pannecouque, M. Preobrazhenskaya, 2003, Journal of medicinal chemistry.

Cytotoxicity of Natural Compounds Isolated from the Seeds of Garcinia afzelii

E. De Clercq, C. Pannecouque, L. Naesens, 2009, Planta medica.

Anti-HIV-1 activity of the G-quadruplex ligand BRACO-19.

Giorgio Palù, Rosalba Perrone, Sara N Richter, 2014, The Journal of antimicrobial chemotherapy.

A yeast-based model of α-synucleinopathy identifies compounds with therapeutic potential

J. Winderickx, C. Pannecouque, F. Leuven, 2006 .

A yeast-based model of alpha-synucleinopathy identifies compounds with therapeutic potential.

J. Winderickx, C. Pannecouque, F. van Leuven, 2006, Biochimica et biophysica acta.

Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA.

E. De Clercq, C. Pannecouque, L. Naesens, 1999, International journal of pharmaceutics.

Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360

E. De Clercq, C. Pannecouque, M. de Maeyer, 2004, AIDS.

Development of Resistance against Diketo Derivatives of Human Immunodeficiency Virus Type 1 by Progressive Accumulation of Integrase Mutations

E. De Clercq, C. Pannecouque, M. de Maeyer, 2003, Journal of Virology.

Measuring cooperative Rev protein-protein interactions on Rev responsive RNA by fluorescence resonance energy transfer

C. Pannecouque, E. Pardon, J. Steyaert, 2011, RNA biology.

Synthesis, In Vitro Anti-HIV Activity, Cytotoxicity, and Computational Studies of Some New Steroids and Their Pyrazoline and Oxime Analogues

C. Pannecouque, R. Winter, N. Al-Masoudi, 2020, Russian Journal of Bioorganic Chemistry.

Isothiazole Derivatives as Antiviral Agents

E. De Clercq, C. Pannecouque, A. Garozzo, 2007, Antiviral chemistry & chemotherapy.

Isothiazole Derivatives as Novel HIV Replication Inhibitors

E. De Clercq, C. Pannecouque, A. Garozzo, 2004, Antiviral chemistry & chemotherapy.

Design, synthesis and anti-HIV evaluation of novel diarylnicotinamide derivatives (DANAs) targeting the entrance channel of the NNRTI binding pocket through structure-guided molecular hybridization.

Peng Zhan, Christophe Pannecouque, E. De Clercq, 2014, European journal of medicinal chemistry.

Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators

E. De Clercq, C. Pannecouque, P. Zhan, 2022, Molecules.

Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, European journal of medicinal chemistry.

Tryptophan Trimers and Tetramers Inhibit Dengue and Zika Virus Replication by Interfering with Viral Attachment Processes

C. Pannecouque, D. Schols, S. Noppen, 2020, Antimicrobial Agents and Chemotherapy.

From design to biological mechanism evaluation of phenylalanine-bearing HIV-1 capsid inhibitors targeting a vital assembly interface

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Chinese Chemical Letters.

Design, synthesis, and antiviral evaluation of novel piperidine-substituted arylpyrimidines as HIV-1 NNRTIs by exploring the hydrophobic channel of NNIBP.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Bioorganic chemistry.

Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies.

E. De Clercq, Dongwei Kang, Boshi Huang, 2021, Journal of medicinal chemistry.

Discovery, optimization, and target identification of novel coumarin derivatives as HIV-1 reverse transcriptase-associated ribonuclease H inhibitors.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, European journal of medicinal chemistry.

Improving Druggability of Novel Diarylpyrimidine NNRTIs by a Fragment-Based Replacement Strategy: From Biphenyl-DAPYs to Heteroaromatic-Biphenyl-DAPYs.

E. De Clercq, C. Pannecouque, Li Ding, 2021, Journal of medicinal chemistry.

Privileged scaffold inspired design of novel oxime-biphenyl-DAPYs in treatment of HIV-1.

C. Pannecouque, E. Clercq, Fener Chen, 2020, Bioorganic chemistry.

Pharmacophore-fusing design of pyrimidine sulfonylacetanilides as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.

E. De Clercq, C. Pannecouque, Fen‐er Chen, 2020, Bioorganic chemistry.

Synthesis and biological evaluation of dihydroquinazoline-2-amines as potent non-nucleoside reverse transcriptase inhibitors of wild-type and mutant HIV-1 strains.

E. De Clercq, C. Pannecouque, Fener Chen, 2019, European journal of medicinal chemistry.

Discovery of potent HIV‐1 non‐nucleoside reverse transcriptase inhibitors by exploring the structure–activity relationship of solvent‐exposed regions I

E. De Clercq, Dongwei Kang, C. Pannecouque, 2019, Chemical biology & drug design.

Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles.

Peng Zhan, F. J. Luque, Ye Tian, 2019, Journal of medicinal chemistry.

Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties.

Peng Zhan, Jian Zhang, F. J. Luque, 2019, Journal of medicinal chemistry.

Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors

T. Steitz, Dongwei Kang, C. Pannecouque, 2018, eLife.

Structural optimization of N1-aryl-benzimidazoles for the discovery of new non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains.

C. Pannecouque, S. Ferro, L. De Luca, 2017, Bioorganic & medicinal chemistry.

Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives as potent HIV-1 NNRTIs.

E. De Clercq, Dongwei Kang, Boshi Huang, 2017, European journal of medicinal chemistry.

S-adenosylhomocysteine hydrolase inhibitors interfere with the replication of human immunodeficiency virus type 1 through inhibition of the LTR transactivation.

E. De Clercq, C. Pannecouque, A. Vandamme, 1997, Molecular pharmacology.

Inhibition of human immunodeficiency virus type 1 transcription by N-aminoimidazole derivatives.

E. De Clercq, C. Pannecouque, P. Herdewijn, 2007, Virology.

Resistance of Human Immunodeficiency Virus Type 1 to the High-Mannose Binding Agents Cyanovirin N and Concanavalin A

L. Stamatatos, E. De Clercq, C. Pannecouque, 2005, Journal of Virology.

Identification of Novel Diarylpyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors by Exploring the Primer Grip Region

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Pharmaceuticals.

Antiviral Activity of Diterpene Esters on Chikungunya Virus and HIV Replication.

C. Pannecouque, L. Delang, J. Neyts, 2015, Journal of natural products.

Isonicotinic acid hydrazide derivatives: synthesis, antimicrobial activity, and QSAR studies

B. Narasimhan, P. Yogeeswari, D. Sriram, 2012, Medicinal Chemistry Research.

Evaluating Clinical Isolates for Their Phenotypic and Genotypic Resistance Against Anti-HIV Drugs.

J Desmyter, E. De Clercq, C. Pannecouque, 2000, Methods in molecular medicine.

CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles.

E. De Clercq, C. Pannecouque, D. Schols, 2012, Dalton transactions.

1H-13C nuclear magnetic resonance assignment and structural characterization of HIV-1 Tat protein.

C. Pannecouque, D. Olive, C. Bailly, 2000, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie.

Design and Synthesis of WM5 Analogues as HIV-1 TAR RNA Binders

C. Pannecouque, B. Gatto, G. Manfroni, 2019, The Open Medicinal Chemistry Journal.

Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype

R. Esnouf, E. De Clercq, C. Pannecouque, 2001, AIDS.

Nitroimidazoles. V. Synthesis and anti-HIV evaluation of new 5-substituted piperazinyl-4-nitroimidazole derivatives

E. De Clercq, C. Pannecouque, N. Al-Masoudi, 2007, Acta pharmaceutica.

Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.

Wim Dehaen, Els Vanstreels, Christophe Pannecouque, 2008, Bioorganic & medicinal chemistry.

HIV-1 Rev function as target for antiretroviral drug development

C. Pannecouque, D. Daelemans, 2006, Current opinion in HIV and AIDS.

Nitroimidazoles, Part 2

C. Pannecouque, Erik de Clercq, N. Al-Masoudi, 2006 .

Inhibition of Human Immunodeficiency Virus Type (HIV-1) Replication by Some Diversely Functionalized Spirocyclopropyl Derivatives.

C. Pannecouque, E. Clercq, M. Witvrouw, 1999 .

Synthesis of 3‐Nitrosoimidazo[1,2‐a]pyridine Derivatives as Potential Antiretroviral Agents

E. De Clercq, C. Pannecouque, A. Kherbeche, 2001, Archiv der Pharmazie.

Discovery of nitropyridine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors via a structure-based core refining approach.

Peng Zhan, Christophe Pannecouque, E. De Clercq, 2014, European journal of medicinal chemistry.

Discovery of novel diarylpyrimidines as potent HIV NNRTIs via a structure-guided core-refining approach.

Peng Zhan, Jan Balzarini, Ye Tian, 2014, European journal of medicinal chemistry.

Correlation of anti-HIV activity with anion spacing in a series of cosalane analogues with extended polycarboxylate pharmacophores.

E. De Clercq, C. Pannecouque, M. Witvrouw, 2001, Journal of medicinal chemistry.

Synthesis and anti-HIV activity of cosalane analogues incorporating nitrogen in the linker chain.

E. De Clercq, C. Pannecouque, M. Witvrouw, 2000, Bioorganic & medicinal chemistry.

Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency.

E. De Clercq, C. Pannecouque, D. Schols, 1999, Journal of medicinal chemistry.

Polyanion inhibitors of HIV and other viruses. 7. Polyanionic compounds and polyzwitterionic compounds derived from cyclodextrins as inhibitors of HIV transmission.

E. De Clercq, C. Pannecouque, J. Neyts, 1998, Journal of medicinal chemistry.

Identification of optimal anion spacing for anti-HIV activity in a series of cosalane tetracarboxylates.

E. De Clercq, C. Pannecouque, M. Witvrouw, 2000, Bioorganic & medicinal chemistry letters.

Synthesis and Anti-HIV Activity of Cosalane Analogues with Substituted Benzoic Acid Rings Attached to the Pharmacophore through Methylene and Amide Linkers

C. Pannecouque, E. Clercq, M. Witvrouw, 1999 .

Inhibition of Human Immunodeficiency Virus Type (HIV‐1) Replication by some Diversely Functionalized Spirocyclopropyl Derivatives

E. De Clercq, C. Pannecouque, M. Witvrouw, 1999, Archiv der Pharmazie.

Debio-025 inhibits HIV-1 by interfering with an early event in the replication cycle.

E. De Clercq, C. Pannecouque, B. Rosenwirth, 2010, Antiviral research.

Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles.

Peng Zhan, Xiao Ding, Dongwei Kang, 2016, Journal of medicinal chemistry.

Cryo-EM structures of Doravirine and Rilpivirine with HIV-1 Reverse Transcriptase/DNA Aptamer – Nonnucleoside Inhibitor Resistance by E138K and M184I Mutations

C. Pannecouque, E. Arnold, P. Herdewijn, 2022, bioRxiv.

A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions

C. Pannecouque, W. Dehaen, Y. Mély, 2012, Retrovirology.

Chicoric acid analogues as HIV-1 integrase inhibitors.

K. Kohn, Y. Pommier, E. De Clercq, 1999, Journal of medicinal chemistry.

Mutations at 65 and 70 within the context of a Q151M cluster in human immunodeficiency virus type 1 reverse transcriptase impact the susceptibility to the different nucleoside reverse transcriptase inhibitors in distinct ways.

C. Pannecouque, A. Vandamme, K. Van Laethem, 2007, Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.

Design, synthesis and biological evaluation of 3-benzyloxy-linked pyrimidinylphenylamine derivatives as potent HIV-1 NNRTIs.

E. De Clercq, C. Pannecouque, P. Zhan, 2013, Bioorganic & medicinal chemistry.

Anti-SARS-CoV-2 Activity and Cytotoxicity of Amaryllidaceae Alkaloids from Hymenocallis littoralis

C. Pannecouque, J. Neyts, L. Pieters, 2023, Molecules.

Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors' Binding Pocket.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, Journal of medicinal chemistry.

Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters.

Y. Pommier, E. De Clercq, C. Pannecouque, 2000, Molecular pharmacology.

Design, synthesis of new β-carboline derivatives and their selective anti-HIV-2 activity.

S. Chander, C. Pannecouque, J. Balzarini, 2015, Bioorganic & medicinal chemistry letters.

Application of the Triazolization Reaction to Afford Dihydroartemisinin Derivatives with Anti-HIV Activity

C. Pannecouque, W. Dehaen, Sampad Jana, 2017, Molecules.

Synthesis, Antiretroviral and Antioxidant Evaluation of a Series of New Benzo[b]furan Derivatives

C. Pannecouque, A. Tsotinis, J. Neyts, 2001, Arzneimittelforschung.

Synthesis and Anti-HIV-1 Activity Evaluation of 5-Alkyl-2-alkylthio-6-(arylcarbonyl or α-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

Jan Balzarini, Erik De Clercq, Christophe Pannecouque, 2007 .

Human Exportin-1 is a Target for Combined Therapy of HIV and AIDS Related Lymphoma

E. Vanstreels, C. Pannecouque, J. J. van den Oord, 2015, EBioMedicine.

Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, International Journal of Molecular Sciences.

Discovery of novel 1,2,4‐triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Journal of medical virology.

Regioselective Suzuki–Miyaura reactions of 4,7-dichloro-N-methylisatin. Synthesis, anti-HIV activity and modeling study

C. Pannecouque, P. Langer, A. Villinger, 2015 .

Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants.

Peng Zhan, Xiao Ding, Ye Tian, 2017, Journal of medicinal chemistry.

Exploration of the in vitro Antiviral Activity of a Series of New Pyrimidine Analogues on the Replication of HIV and HCV

C. Pannecouque, P. Leyssen, N. Al-Masoudi, 2012, Antiviral chemistry & chemotherapy.

Design, Synthesis, and Biological Evaluation of Novel 3,5‐Disubstituted‐1,2,6‐Thiadiazine‐1,1‐Dione Derivatives as HIV‐1 NNRTIs

Peng Zhan, Jan Balzarini, Ye Tian, 2013, Chemical biology & drug design.

Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, Acta pharmaceutica Sinica. B.

Chemical space exploration around indolylarylsulfone scaffold led to a novel class of highly active HIV-1 NNRTIs with spiro structural features.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, European journal of medicinal chemistry.

Studies of Anti‐HIV Transcription Inhibitor Quinolones: Identification of Potent N1‐Vinyl Derivatives

C. Pannecouque, B. Gatto, M. Palumbo, 2010, ChemMedChem.

Antiretroviral activity of metal-chelating HIV-1 integrase inhibitors.

C. Pannecouque, L. Naesens, M. Carcelli, 2014, European journal of medicinal chemistry.

Polyfluoroaromatic stavudine (d4T) ProTides exhibit enhanced anti-HIV activity.

C. Pannecouque, A. Westwell, C. Mcguigan, 2019, Bioorganic & medicinal chemistry letters.

Development of novel S-N3-DABO derivatives as potent non-nucleoside reverse transcriptase inhibitors with improved potency and selectivity.

F. Chen, E. De Clercq, C. Pannecouque, 2022, European journal of medicinal chemistry.

Structure-directed expansion of biphenyl-pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with significantly improved potency and safety

F. Chen, E. De Clercq, C. Pannecouque, 2023, Chinese Chemical Letters.

Structure-guided design of novel HEPT analogs with enhanced potency and safety: From Isopropyl-HEPTs to Cyclopropyl-HEPTs.

F. Chen, C. Pannecouque, Shuaige Wang, 2022, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of novel 5‐Alkyl‐6‐Adamantylmethylpyrimidin‐4(3H)‐ones as HIV‐1 non‐nucleoside reverse‐transcriptase inhibitors

E. De Clercq, Dongwei Kang, Boshi Huang, 2016, Chemical biology & drug design.

Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. Part 11. Structural Modulations of Diaryltriazines with Potent anti-HIV Activity.

C. Pannecouque, J. Balzarini, Fener Chen, 2008 .

Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors.

Peng Zhan, Jan Balzarini, Xuwang Chen, 2012, European journal of medicinal chemistry.

Synthesis and Biological Evaluation of a Series of 2‐((1‐substituted‐1H‐1,2,3‐triazol‐4‐yl)methylthio)‐6‐(naphthalen‐1‐ylmethyl)pyrimidin‐4(3H)‐one As Potential HIV‐1 Inhibitors

Peng Zhan, Dongwei Kang, Christophe Pannecouque, 2015, Chemical biology & drug design.

Design, synthesis and biological evaluation of substituted guanidine indole derivatives as potential inhibitors of HIV-1 Tat-TAR interaction.

E. De Clercq, C. Pannecouque, P. Zhan, 2013, Medicinal chemistry (Shariqah (United Arab Emirates)).

New Class of HIV Integrase Inhibitors that Block Viral Replication in Cell Culture

Myriam Witvrouw, Zeger Debyser, Erik De Clercq, 2002, Current Biology.

Synthesis, crystal structure, anti-HIV, and antiproliferative activity of new pyrazolylthiazole derivatives

C. Pannecouque, M. Tahir, S. Hameed, 2017, Medicinal Chemistry Research.

Design, Synthesis, and Anti‐HIV Evaluation of Novel Triazine Derivatives Targeting the Entrance Channel of the NNRTI Binding Pocket

E. De Clercq, Huiqing Liu, C. Pannecouque, 2015, Chemical biology & drug design.

Anti-HIV and antiplasmodial activity of original flavonoid derivatives.

C. Pannecouque, M. Robin, N. Azas, 2010, Bioorganic & medicinal chemistry.

Synthesis and anti-HIV evaluation of new 2-Thioxoimidazolidin-4-ones and their Arylidine (styryl) derivatives

C. Pannecouque, E. Clercq, K. Chikhalia, 2012, Pharmaceutical Chemistry Journal.

A stably expressed llama single-domain intrabody targeting Rev displays broad-spectrum anti-HIV activity.

E. Vanstreels, Guangdi Li, C. Pannecouque, 2014, Antiviral research.

New chalcones and thiopyrimidine analogues derived from mefenamic acid: microwave-assisted synthesis, anti-HIV activity and cytotoxicity as antileukemic agents

C. Pannecouque, N. Al-Masoudi, B. Saeed, 2017 .

alpha-Amino acids derived from ornithine as building blocks for peptide synthesis.

C. Pannecouque, P. Herdewijn, R. Busson, 2009, The journal of peptide research : official journal of the American Peptide Society.

Amino acids derived from ornithine

C. Pannecouque, P. Herdewijn, J. Rozenski, 1995, Letters in Peptide Science.

A Novel Series of Indole Alkaloid Derivatives Inhibit Dengue and Zika Virus Infection by Interference with the Viral Replication Complex

P. Lemey, C. Pannecouque, D. Schols, 2021, Antimicrobial agents and chemotherapy.

Potent and Selective Inhibition of HIV and SIV by Prostratin Interacting with Viral Entry

E. De Clercq, C. Pannecouque, M. Witvrouw, 2003, Antiviral chemistry & chemotherapy.

Design and synthesis of a new series of cyclopropylamino-linking diarylpyrimidines as HIV non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, J. Balzarini, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Design and synthesis of a new series of modified CH-diarylpyrimidines as drug-resistant HIV non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, J. Balzarini, 2014, European journal of medicinal chemistry.

Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 2: discovery of novel [1,2,4]Triazolo[1,5-a]pyrimidines using a structure-guided core-refining approach.

Peng Zhan, Ye Tian, Christophe Pannecouque, 2014, European journal of medicinal chemistry.

Synthesis of aryl semicarbazone of 4-aminoacetophenone and their anti-HIV activity.

C. Pannecouque, M. Witvrouw, S. Pandeya, 1998, Pharmaceutica acta Helvetiae.

Synthesis of new covalently bound kappa-carrageenan-AZT conjugates with improved anti-HIV activities.

Myriam Witvrouw, Christophe Pannecouque, Jean-Louis Kraus, 2002, Journal of medicinal chemistry.

Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, RSC medicinal chemistry.

Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines.

E. De Clercq, Boshi Huang, Huiqing Liu, 2015, European journal of medicinal chemistry.

Fragment Hopping-Based Design of Novel Biphenyl-DAPY Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Significantly Improved Anti-Resistance Efficacy.

F. Chen, E. De Clercq, C. Pannecouque, 2023, Journal of medicinal chemistry.

Structural modification of diarylpyrimidine derivatives as HIV-1 reverse transcriptase inhibitors

C. Pannecouque, J. Balzarini, E. Clercq, 2014, Medicinal Chemistry Research.

Non‐nucleoside HIV Reverse Transcriptase Inhibitors, Part 6[1]: Synthesis and Anti‐HIV Activity of Novel 2‐[(Arylcarbonylmethyl)thio]‐6‐arylthio DABO Analogues

E. De Clercq, C. Pannecouque, J. Balzarini, 2005, Archiv der Pharmazie.

Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, M. Cushman, 2009, European journal of medicinal chemistry.

Design and synthesis of hybrids of diarylpyrimidines and diketo acids as HIV-1 inhibitors.

C. Pannecouque, P. Xue, Shuang‐Xi Gu, 2017, Bioorganic & medicinal chemistry letters.

Non‐nucleoside HIV Reverse Transcriptase Inhibitors. Part 6. Synthesis and Anti‐HIV Activity of Novel 2‐[(Arylcarbonylmethyl)thio]‐6‐arylthio DABO Analogues.

E. De Clercq, C. Pannecouque, J. Balzarini, 2006 .

Synthesis of novel biologically active methylene derivatives of sydnones

C. Pannecouque, C. Supuran, E. Clercq, 2013, Medicinal Chemistry Research.

Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents

C. Pannecouque, L. Naesens, P. Zhan, 2012, Archives of pharmacal research.

Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket.

E. De Clercq, Dongwei Kang, Boshi Huang, 2016, European journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Novel 2‐(Pyridin‐3‐yloxy)acetamide Derivatives as Potential Anti‐HIV‐1 Agents

E. De Clercq, Boshi Huang, C. Pannecouque, 2016, Chemical biology & drug design.

Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs.

Peng Zhan, Jan Balzarini, Xuwang Chen, 2014, Bioorganic & medicinal chemistry.

Design, Synthesis and Anti-HIV-1 Evaluation of Novel Arylazolylthioacetanilides as Potent NNRTIS

C. Pannecouque, P. Zhan, Xinyong Liu, 2009 .

Synthesis and anti-HIV activity of some new aminoadamantane heterocycles

C. Pannecouque, E. Clercq, M. Witvrouw, 1997 .

Selective Inhibitors of Nuclear Export (SINE) Compounds Suppress Both HIV Replication and AIDS Related Lymphoma

E. Vanstreels, C. Pannecouque, T. Vercruysse, 2015 .

Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs.

Peng Zhan, Jan Balzarini, Christophe Pannecouque, 2013, Bioorganic & medicinal chemistry.

Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, Huiqing Liu, C. Pannecouque, 2013, Bioorganic & medicinal chemistry letters.

Structural optimization of pyridine-type DAPY derivatives to exploit the tolerant regions of the NNRTI binding pocket.

E. De Clercq, Boshi Huang, C. Pannecouque, 2016, European journal of medicinal chemistry.

NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS

C. Pannecouque, J. Balzarini, E. Clercq, 2004 .

Inhibition of tubulin polymerization by select alkenyldiarylmethanes.

E. De Clercq, C. Pannecouque, M. Cushman, 2008, Bioorganic & medicinal chemistry letters.

The Phthalocyanine Prototype Derivative Alcian Blue Is the First Synthetic Agent with Selective Anti-Human Immunodeficiency Virus Activity Due to Its gp120 Glycan-Binding Potential

C. Pannecouque, J. Balzarini, D. Schols, 2009, Antimicrobial Agents and Chemotherapy.

Anti-HIV activity of a series of cosalane amino acid conjugates.

E. De Clercq, C. Pannecouque, M. Witvrouw, 2000, Bioorganic & medicinal chemistry letters.

G-Quadruplexes in the Human Immunodeficiency Virus-1 and Herpes Simplex Virus-1: New Targets for Antiviral Activity by Small Molecules

C. Pannecouque, S. Richter, M. Nadai, 2015 .

Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility

F. Chen, C. Pannecouque, E. Clercq, 2023, Acta Pharmaceutica Sinica B.

Author response: Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors

T. Steitz, Dongwei Kang, C. Pannecouque, 2018 .

Identification of Boronate-Containing Diarylpyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

Dongwei Kang, C. Pannecouque, P. Zhan, 2022, Molecules.

Comprehensive study of alkaloids from Scadoxus multiflorus by HPLC-PDA-SPE-NMR and evaluation of their anti-SARS-CoV-2 activity

C. Pannecouque, J. Neyts, L. Pieters, 2023, Phytochemistry Letters.

Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors

T. Steitz, Dongwei Kang, C. Pannecouque, 2018, eLife.

Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV.

E. De Clercq, C. Pannecouque, J. Balzarini, 2010, Bioorganic & Medicinal Chemistry.

Discovery of novel DAPY-IAS hybrid derivatives as potential HIV-1 inhibitors using molecular hybridization based on crystallographic overlays.

Peng Zhan, Xueshun Wang, Christophe Pannecouque, 2017, Bioorganic & medicinal chemistry.

Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization.

Peng Zhan, Ye Tian, Dongwei Kang, 2017, European journal of medicinal chemistry.

Structural modifications of CH(OH)-DAPYs as new HIV-1 non-nucleoside reverse transcriptase inhibitors.

Christophe Pannecouque, E. De Clercq, C. Pannecouque, 2014, Bioorganic & medicinal chemistry.

Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, J. Balzarini, 2007, Journal of medicinal chemistry.

Discovery of nitropyridine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors via a structure-based core refining approach.

E. De Clercq, Huiqing Liu, C. Pannecouque, 2014, European journal of medicinal chemistry.

5-Cyano substituted diarylpyridines as potent HIV-1 NNRTIs: Rational design, synthesis, and activity evaluation.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, European journal of medicinal chemistry.

Discovery of Piperidine‐Linked Pyridine Analogues as Potent Non‐nucleoside HIV‐1 Reverse Transcriptase Inhibitors

Huiqing Liu, C. Pannecouque, Xinyong Liu, 2013, ChemMedChem.

Structural Modifications of DAPY Analogues with Potent Anti‐HIV‐1 Activity

C. Pannecouque, J. Balzarini, Fener Chen, 2009, ChemMedChem.

CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles.

E. De Clercq, C. Pannecouque, D. Schols, 2012, Dalton transactions.

1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, P. Zhan, 2008, Bioorganic & medicinal chemistry letters.

Improving the anti-HIV-1 activity and solubility of poorly water-soluble DAPYs by heteroaromatic replacement strategy: From naphthalene-DAPYs to quinoline-DAPYs.

F. Chen, E. De Clercq, C. Pannecouque, 2023, Bioorganic chemistry.

Anti-HIV diarylpyrimidine-quinolone hybrids and their mode of action.

E. De Clercq, C. Pannecouque, D. Daelemans, 2015, Bioorganic & medicinal chemistry.

Amino acid derivatives. Part 6. Synthesis, in vitro antiviral activity and molecular docking study of new N-α-amino acid derivatives conjugated spacer phthalimide backbone

C. Pannecouque, N. Al-Masoudi, Einas Abood, 2016, Medicinal Chemistry Research.

Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors

E. De Clercq, Dongwei Kang, Boshi Huang, 2023, Communications chemistry.

Design, Synthesis, and Anti‐HIV Evaluation of Novel Triazine Derivatives Targeting the Entrance Channel of the NNRTI Binding Pocket

E. De Clercq, Huiqing Liu, C. Pannecouque, 2015, Chemical biology & drug design.

Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound.

E. De Clercq, C. Pannecouque, J. Balzarini, 2008, Bioorganic & medicinal chemistry letters.

Discovery of piperidin-4-yl-aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, D. Daelemans, 2015, European journal of medicinal chemistry.

Synthesis and biological evaluation of CHX-DAPYs as HIV-1 non-nucleoside reverse transcriptase inhibitors.

Christophe Pannecouque, E. De Clercq, C. Pannecouque, 2014, Bioorganic & medicinal chemistry.

Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents.

Jan Balzarini, Laura De Luca, Maria Zappalà, 2002, Journal of medicinal chemistry.

Synthesis and Antiviral Activities of Some New 5-Heteroaromatic Substituted Derivatives of 2′-Deoxyuridine

C. Pannecouque, P. Herdewijn, A. Aerschot, 1995 .

Resistance of Human Immunodeficiency Virus Type 1 to the High-Mannose Binding Agents Cyanovirin N and Concanavalin A

L. Stamatatos, E. De Clercq, C. Pannecouque, 2005, Journal of Virology.

Phytochemical and biological investigations of Elaeodendron schlechteranum.

C. Pannecouque, D. Ferreira, S. Apers, 2010, Journal of ethnopharmacology.

Escaping from Flatland: Multiparameter Optimization Leads to the Discovery of Novel Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Human Immunodeficiency Virus-1 Non-nucleoside Reverse Transcriptase Inhibitors with Superior Antiviral Activities against Non-nucleoside Reverse Transcriptase Inhibito

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, Journal of medicinal chemistry.

Nicotinic Acid Benzylidene/Phenyl-Ethylidene Hydrazides: Synthesis, Antimicrobial Evaluation and QSAR Studies

B. Narasimhan, P. Yogeeswari, D. Sriram, 2011 .

Computer‐Aided Design, Synthesis and Validation of 2‐Phenylquinazolinone Fragments as CDK9 Inhibitors with Anti‐HIV‐1 Tat‐Mediated Transcription Activity

C. Pannecouque, A. Marcello, S. Sabatini, 2013, ChemMedChem.