P. Zhan

发表

Synthesis and Preliminary Antiviral Activities of Piperidine‐substituted Purines against HIV and Influenza A/H1N1 Infections

E. De Clercq, Dongwei Kang, Zengjun Fang, 2015, Chemical biology & drug design.

Discovery and characterization of novel imidazopyridine derivative CHEQ-2 as a potent CDC25 inhibitor and promising anticancer drug candidate.

Peng Zhan, Dongwei Kang, Yu'ning Song, 2014, European journal of medicinal chemistry.

Discovery of C-1 modified oseltamivir derivatives as potent influenza neuraminidase inhibitors.

P. Zhan, Xinyong Liu, Han Ju, 2018, European journal of medicinal chemistry.

The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic.

P. Zhan, Xinyong Liu, J. Kongsted, 2018, Journal of medicinal chemistry.

Development of Novel Dihydrofuro[3,4-d]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Journal of medicinal chemistry.

Exploiting the hydrophobic channel of the NNIBP: Discovery of novel diarylpyrimidines as HIV-1 NNRTIs against wild-type and K103N mutant viruses.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Bioorganic & medicinal chemistry.

Boronic acid-containing diarylpyrimidine derivatives as novel HIV-1 NNRTIs: Design, synthesis and biological evaluation

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021 .

Identification of novel potent HIV-1 inhibitors by exploiting the tolerant regions of the NNRTIs binding pocket.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, European journal of medicinal chemistry.

Discovery of Novel Dihydrothiopyrano[4,3-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs with Significantly Reduced hERG Inhibitory Activity and Improved Resistance Profiles.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Journal of medicinal chemistry.

Design, synthesis and anti-HIV evaluation of novel 5-substituted diarylpyrimidine derivatives as potent HIV-1 NNRTIs.

E. De Clercq, C. Pannecouque, P. Zhan, 2021, Bioorganic & medicinal chemistry.

Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV‑1 non-nucleoside reverse transcriptase inhibitors

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Bioorganic & Medicinal Chemistry.

In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, European journal of medicinal chemistry.

Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties.

E. De Clercq, Dongwei Kang, Boshi Huang, 2020, European journal of medicinal chemistry.

Structure-Activity Relationship Exploration of NNIBP Tolerant Region I Leads to Potent HIV-1 NNRTIs.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, ACS infectious diseases.

Discovery and Characterization of Fluorine-Substituted Diarylpyrimidines Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel.

Peng Zhan, Dongwei Kang, Yanying Sun, 2020, Journal of medicinal chemistry.

Structure-Based Bioisosterism Yields HIV 1 NNRTIs with Improved Drug Resistance Profiles and Favorable Pharmacokinetic Properties.

E. De Clercq, Dongwei Kang, Zengjun Fang, 2020, Journal of medicinal chemistry.

Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, European journal of medicinal chemistry.

Design, synthesis, and evaluation of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, European journal of medicinal chemistry.

Discovery of piperidine-substituted thiazolo[5,4-d]pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors

E. De Clercq, Dongwei Kang, Boshi Huang, 2019, Communications Chemistry.

Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2017, ACS medicinal chemistry letters.

Design strategies of novel NNRTIs to overcome drug resistance.

Peng Zhan, Christophe Pannecouque, E. De Clercq, 2009, Current medicinal chemistry.

Strategies for the design of HIV-1 non-nucleoside reverse transcriptase inhibitors: lessons from the development of seven representative paradigms.

Peng Zhan, E. De Clercq, P. Zhan, 2012, Journal of medicinal chemistry.

HIV‐1 NNRTIs: structural diversity, pharmacophore similarity, and impliations for drug design

Peng Zhan, Xuwang Chen, Zengjun Fang, 2013, Medicinal research reviews.

Novel fluorine-containing DAPY derivatives as potent HIV-1 NNRTIs: a patent evaluation of WO2014072419

Boshi Huang, P. Zhan, Xinyong Liu, 2015, Expert opinion on therapeutic patents.

Novel diarylpyrimidines and diaryltriazines as potent HIV-1 NNRTIs with dramatically improved solubility: a patent evaluation of US20140378443A1

Dongwei Kang, Boshi Huang, P. Zhan, 2016, Expert opinion on therapeutic patents.

Current insights into anti-HIV drug discovery and development: a review of recent patent literature (2014–2017)

Peng Zhan, Dongwei Kang, Gaochan Wu, 2018, Expert opinion on therapeutic patents.

Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the "NNRTI Adjacent" Binding Site.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2018, ACS medicinal chemistry letters.

Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery.

Dongwei Kang, Boshi Huang, C. Pannecouque, 2018, ACS medicinal chemistry letters.

Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries.

Dongwei Kang, P. Zhan, Xinyong Liu, 2019, European journal of medicinal chemistry.

Benzimidazole Heterocycle as a Privileged Scaffold in Antiviral Agents

P. Zhan, Xinyong Liu, Dongyue Li, 2012 .

Overview of Recent Strategic Advances in Medicinal Chemistry.

Peng Zhan, Yuning Song, Dongwei Kang, 2019, Journal of medicinal chemistry.

Identification of Chebulinic Acid and Chebulagic Acid as Novel Influenza Viral Neuraminidase Inhibitors

P. Zhan, Xinyong Liu, Lijun Rong, 2020, Frontiers in Microbiology.

Discovery of novel 1,2,3-triazole oseltamivir derivatives as potent influenza neuraminidase inhibitors targeting the 430-cavity.

P. Zhan, Xinyong Liu, Xiao Ding, 2019, European journal of medicinal chemistry.

Influenza A virus polymerase: an attractive target for next-generation anti-influenza therapeutics.

P. Zhan, Xinyong Liu, Jian Zhang, 2018, Drug discovery today.

Blocking nuclear import of pre-integration complex: an emerging anti-HIV-1 drug discovery paradigm.

E. De Clercq, P. Zhan, Xinyong Liu, 2010, Current medicinal chemistry.

The development of HEPT-type HIV non-nucleoside reverse transcriptase inhibitors and its implications for DABO family.

P. Zhan, Xinyong Liu, Jingde Wu, 2012, Current pharmaceutical design.

Differentiated human adipose-derived stromal cells exhibit the phenotypic and functional characteristics of mature Schwann cells through a modified approach.

P. Zhan, Wei Liu, Jing Chen, 2019, Cytotherapy.

Contemporary medicinal-chemistry strategies for discovery of blood coagulation factor Xa inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2019, Expert opinion on drug discovery.

Inhibitors of Influenza Virus Polymerase Acidic (PA) Endonuclease: Contemporary Developments and Perspectives.

Dongwei Kang, Boshi Huang, P. Zhan, 2017, Journal of medicinal chemistry.

Discovery of HCV NS5B thumb site I inhibitors: core-refining from benzimidazole to indole scaffold.

P. Zhan, Xinyong Liu, Na Liu, 2015, European journal of medicinal chemistry.

Targeting the entry step of SARS-CoV-2: a promising therapeutic approach

P. Zhan, Xinyong Liu, Jing Li, 2020, Signal Transduction and Targeted Therapy.

Arylazolyl(azinyl)thioacetanilides: Part 19 : Discovery of Novel Substituted Imidazo[4,5‐b]pyridin‐2‐ylthioacetanilides as Potent HIV NNRTIs Via a Structure‐based Bioisosterism Approach

E. De Clercq, Boshi Huang, C. Pannecouque, 2016, Chemical biology & drug design.

Substituted indoles as HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent evaluation (WO2015044928)

P. Zhan, Xinyong Liu, Xiao Li, 2016, Expert opinion on therapeutic patents.

Facile Synthesis of Derivatives of 1,1,3‐Trioxo‐2H,4H‐pyrrolo[1,2‐b][1,2,4,6]thiatriazine: A New Heterocyclic System.

Peng Zhan, Boshi Huang, Boshi Huang, 2014 .

Recent advances in the discovery and development of novel HIV-1 NNRTI platforms (Part II): 2009-2013 update.

Peng Zhan, Yu'ning Song, Zengjun Fang, 2013, Current medicinal chemistry.

Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2019, European journal of medicinal chemistry.

Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus.

E. De Clercq, Dongwei Kang, Boshi Huang, 2018, European journal of medicinal chemistry.

The discovery of novel diarylpyri(mi)dine derivatives with high level activity against a wide variety of HIV-1 strains as well as against HIV-2.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2018, Bioorganic & medicinal chemistry.

Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement.

E. De Clercq, Boshi Huang, Huiqing Liu, 2017, European journal of medicinal chemistry.

Arylazolyl(azinyl)thioacetanilides. Part 20: Discovery of novel purinylthioacetanilides derivatives as potent HIV-1 NNRTIs via a structure-based bioisosterism approach.

E. De Clercq, Dongwei Kang, Boshi Huang, 2016, Bioorganic & medicinal chemistry.

Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches.

E. De Clercq, Boshi Huang, Huiqing Liu, 2015, European journal of medicinal chemistry.

Fragment-based approaches to anti-HIV drug discovery: state of the art and future opportunities

Dongwei Kang, Boshi Huang, P. Zhan, 2015, Expert opinion on drug discovery.

Design, synthesis and evaluation of novel HIV-1 NNRTIs with dual structural conformations targeting the entrance channel of the NNRTI binding pocket.

E. De Clercq, Dongwei Kang, Boshi Huang, 2016, European journal of medicinal chemistry.

[The application of structural optimization strategies in drug design of HIV NNRTIs].

P. Zhan, Liu Wang, Xin-yong Liu, 2012, Yao xue xue bao = Acta pharmaceutica Sinica.

The GSK-3β/β-catenin signaling pathway is involved in HMGB1-induced chondrocyte apoptosis and cartilage matrix degradation

P. Zhan, Lang-qing Zeng, Zhi-ming Shu, 2020, International journal of molecular medicine.

Recent developments in the medicinal chemistry of single boron atom-containing compounds

Dongwei Kang, P. Zhan, Xinyong Liu, 2021, Acta pharmaceutica Sinica. B.

Downregulation of Ca2+-Activated Cl− Channel TMEM16A by the Inhibition of Histone Deacetylase in TMEM16A-Expressing Cancer Cells

P. Zhan, Takayoshi Suzuki, K. Muraki, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Downregulation of Ca 2 1-Activated Cl 2 Channel TMEM 16 A by the Inhibition of Histone Deacetylase in TMEM 16 A-Expressing Cancer Cells s

P. Zhan, Takayoshi Suzuki, K. Muraki, 2014 .

Discovery of Novel Bicyclic Imidazolopyridine-Containing Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Improved Efficacy and Favorable Druggability.

P. Zhan, Xinyong Liu, Jianbo Ji, 2022, Journal of medicinal chemistry.

Development of PI3K inhibitors: advances in clinical trials and new strategies (Review).

P. Zhan, Lintao Cai, Wei He, 2021, Pharmacological research.

Advances in Natural Products‐Based Antiviral Agents

P. Zhan, Xinyong Liu, L. Menéndez-Arias, 2021 .

Newly Emerging Strategies in Antiviral Drug Discovery: Dedicated to Prof. Dr. Erik De Clercq on Occasion of His 80th Anniversary

Dongwei Kang, Boshi Huang, P. Zhan, 2022, Molecules.

Punicalagin is a neuraminidase inhibitor of influenza viruses

Dongwei Kang, P. Zhan, Xinyong Liu, 2020, Journal of medical virology.

Identification of spirocyclic or phosphate substituted quinolizine derivatives as novel HIV-1 integrase inhibitors: a patent evaluation of WO2016094197A1, WO2016094198A1 and WO2016154527A1

P. Zhan, Xinyong Liu, Lin Sun, 2017, Expert opinion on therapeutic patents.

HIV-1 and HBV RNase H as Metal-Chelating Inhibitors: Discovery and Medicinal Chemistry Strategies

P. Zhan, Xinyong Liu, Fenju Wei, 2021 .

Recent Developments in Small Molecular HIV‐1 and Hepatitis B Virus RNase H Inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2020, Advances in Metallodrugs.

Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities

P. Zhan, Xinyong Liu, Han Ju, 2020, Journal of medicinal chemistry.

Repurposing of HDAC inhibitors toward anti-hepatitis C virus drug discovery: teaching an old dog new tricks.

P. Zhan, Xinyong Liu, Na Liu, 2015, Future medicinal chemistry.

2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Journal of medicinal chemistry.

Identification of C5-NH2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability.

Dongwei Kang, P. Zhan, Xinyong Liu, 2021, Journal of medicinal chemistry.

Fsp3: A new parameter for drug-likeness.

P. Zhan, Xinyong Liu, Lanlan Jing, 2020, Drug discovery today.

Discovery of Non‐Peptide Small Molecular CXCR4 Antagonists as anti‐HIV Agents: Recent Advances and Future Opportunities

Dongwei Kang, Boshi Huang, P. Zhan, 2016 .

Discovery of non-peptide small molecular CXCR4 antagonists as anti-HIV agents: Recent advances and future opportunities.

Dongwei Kang, Boshi Huang, P. Zhan, 2016, European journal of medicinal chemistry.

A N-propionylsulfonamide prodrug of K-5a2 provided improved aqueous solubility and hERG inhibition

Dongwei Kang, C. Pannecouque, P. Zhan, 2020 .

Searching for potential inhibitors of SARS-COV-2 main protease using supervised learning and perturbation calculations

Son Tung Ngo, Duong Tuan Quang, P. Zhan, 2022, Chemical Physics.

Novel fused pyrimidine and isoquinoline derivatives as potent HIV-1 NNRTIs: a patent evaluation of WO2016105532A1, WO2016105534A1 and WO2016105564A1

Dongwei Kang, P. Zhan, Xinyong Liu, 2017, Expert opinion on therapeutic patents.

Pyrazolo[1,5-a]pyrimidine-based macrocycles as novel HIV-1 inhibitors: a patent evaluation of WO2015123182

P. Zhan, Xinyong Liu, Lin Sun, 2016, Expert opinion on therapeutic patents.

Design, synthesis, and biological evaluation of novel sulfamoylbenzamide derivatives as HBV capsid assembly modulators

P. Zhan, Xinyong Liu, J. Tavis, 2022, Bioorganic Chemistry.

Design, Synthesis, and Evaluation of a Set of Carboxylic Acid and Phosphate Prodrugs Derived from HBV Capsid Protein Allosteric Modulator NVR 3-778

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Molecules.

Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel".

E. De Clercq, Dongwei Kang, C. Pannecouque, 2018, Organic & biomolecular chemistry.

Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors from arylthioacetanilide structural motif.

E. De Clercq, P. Zhan, Xinyong Liu, 2015, European journal of medicinal chemistry.

MDA19, a novel CB2 agonist, inhibits hepatocellular carcinoma partly through inactivation of AKT signaling pathway

P. Zhan, Mei-Chun Rao, Dongfeng Chen, 2019, Biology Direct.

Recent advance of the hepatitis B virus inhibitors: a medicinal chemistry overview.

P. Zhan, Xinyong Liu, Xuwang Chen, 2015, Future medicinal chemistry.

Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability.

Dongwei Kang, P. Zhan, Xinyong Liu, 2020, Journal of medicinal chemistry.

Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of tacrine-1,2,3-triazole derivatives as potent cholinesterase inhibitors.

Dongwei Kang, Boshi Huang, Huiqing Liu, 2018, MedChemComm.

Discovery of highly potent and selective influenza virus neuraminidase inhibitors targeting 150-cavity.

P. Zhan, Xinyong Liu, A. Loregian, 2020, European journal of medicinal chemistry.

The Changing Face of Hepatitis C: Recent Advances on HCV Inhibitors Targeting NS5A

E. De Clercq, P. Zhan, Xinyong Liu, 2015, Current medicinal chemistry.

SMIP-30, a potent and selective PPM1A inhibitor with potential to treat tuberculosis

P. Zhan, Xinyong Liu, Shujing Xu, 2022, Acta Pharmaceutica Sinica B.

Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7.

E. De Clercq, Dongwei Kang, Boshi Huang, 2020, Bioorganic & Medicinal Chemistry Letters.

Synthesis, In Vitro and In Vivo Release Kinetics, and Anti‐HIV Activity of A Sustained‐Release Prodrug (mPEG‐AZT) of 3′‐Azido‐3′‐deoxythymidine (AZT, Zidovudine)

C. Pannecouque, P. Zhan, Xinyong Liu, 2010, ChemMedChem.

Design, synthesis and activity evaluation of novel lesinurad analogues containing thienopyrimidinone or pyridine substructure as human urate transporter 1 inhibitors.

P. Zhan, Xinyong Liu, Jian Zhang, 2022, European journal of medicinal chemistry.

An insight on medicinal aspects of novel HIV-1 capsid protein inhibitors.

P. Zhan, Xinyong Liu, Tianguang Huang, 2021, European journal of medicinal chemistry.

Discovery of Novel Boron-Containing N-Substituted Oseltamivir Derivatives as Anti-Influenza A Virus Agents for Overcoming N1-H274Y Oseltamivir-Resistant

P. Zhan, Xinyong Liu, A. Loregian, 2022, Molecules.

Discovery and optimizing polycyclic pyridone compounds as anti-HBV agents

Dongwei Kang, P. Zhan, Xinyong Liu, 2020, Expert opinion on therapeutic patents.

Discovery and optimization of benzenesulfonamides-based hepatitis B virus capsid modulators via contemporary medicinal chemistry strategies.

P. Zhan, Xinyong Liu, J. Tavis, 2020, European journal of medicinal chemistry.

Current medicinal chemistry strategies in the discovery of novel HIV-1 ribonuclease H inhibitors.

P. Zhan, Xinyong Liu, L. Menéndez-Arias, 2022, European journal of medicinal chemistry.

The discovery and design of novel HIV-1 capsid modulators and future perspectives

P. Zhan, Xinyong Liu, Xiangyi Jiang, 2022, Expert opinion on drug discovery.

HIV-1 capsid inhibitors: a sword to destroy the virus.

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Future medicinal chemistry.

Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2019, Bioorganic & medicinal chemistry.

Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity.

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Journal of medicinal chemistry.

Design, Synthesis, and Mechanism Study of Benzenesulfonamide-containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, Journal of medicinal chemistry.

Current trends in designing antiviral agents against emerging and re-emerging RNA viruses

P. Zhan, E. D. da Silva-Júnior, 2022, Bioorganic & Medicinal Chemistry.

Medicinal chemistry strategies of targeting HIV-1 capsid protein for antiviral treatment.

Boshi Huang, P. Zhan, Xinyong Liu, 2020, Future medicinal chemistry.

Medicinal chemistry insights into antiviral peptidomimetics.

P. Zhan, Xinyong Liu, E. D. da Silva-Júnior, 2022, Drug discovery today.

SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules

P. Zhan, Xinyong Liu, Peihui Wang, 2022, Signal Transduction and Targeted Therapy.

8-Hydroxyquinoline: a privileged structure with a broad-ranging pharmacological potential

P. Zhan, Xinyong Liu, Yu'ning Song, 2015 .

Identification of novel SIRT2-selective inhibitors using a click chemistry approach.

Peng Zhan, Yukihiro Itoh, Takayoshi Suzuki, 2014, Bioorganic & medicinal chemistry letters.

Design, synthesis and primary biological evaluation of the novel 2-pyridone derivatives as potent non-nucleoside HBV inhibitors.

P. Zhan, Xinyong Liu, Chunhong Ma, 2017, European journal of medicinal chemistry.

Non-nucleoside anti-HBV agents: advances in structural optimization and mechanism of action investigations

P. Zhan, Xinyong Liu, Na Liu, 2015 .

Design, synthesis and biological evaluation of novel trimethylpyrazine-2-carbonyloxy-cinnamic acids as potent cardiovascular agents

P. Zhan, Xinyong Liu, Hong Li, 2014 .

Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Journal of medicinal chemistry.

Recent advances in the discovery and development of novel HIV-1 NNRTI platforms: 2006-2008 update.

Peng Zhan, P. Zhan, Xinyong Liu, 2009, Current medicinal chemistry.

Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on crystallographic overlays.

Peng Zhan, Jan Balzarini, Christophe Pannecouque, 2014, Bioorganic & medicinal chemistry.

Synthesis and Anti‐HIV Activity of 4‐(Naphthalen‐1‐yl)‐1,2,5‐thiadiazol‐3‐hydroxyl Derivatives

E. De Clercq, C. Pannecouque, P. Zhan, 2014, Chemical biology & drug design.

Synthesis and Anti‐HIV Activity Evaluation of Novel 2,4‐Disubstituted 7‐Methyl‐1,1,3‐trioxo‐2,4‐dihydro‐pyrazolo‐[4,5‐e][1,2]thiadiazines

E. De Clercq, C. Pannecouque, P. Zhan, 2008, Archiv der Pharmazie.

Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Chemical Society reviews.

Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends.

Peng Zhan, Christophe Pannecouque, E. De Clercq, 2016, Journal of medicinal chemistry.

Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

Zengjun Fang, C. Pannecouque, P. Zhan, 2009, Bioorganic & medicinal chemistry.

Naturally occurring and synthetic bioactive molecules as novel non-nucleoside HBV inhibitors.

P. Zhan, Xinyong Liu, Xuemei Jiang, 2010, Mini reviews in medicinal chemistry.

Synthesis and Anti-HIV Evaluation of Novel 1,2,4-triazole Derivatives as Potential Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

C. Pannecouque, P. Zhan, Xinyong Liu, 2012 .

Conformational restriction: an effective tactic in 'follow-on'-based drug discovery.

Peng Zhan, Yu'ning Song, Qingzhu Zhang, 2014, Future medicinal chemistry.

Discovery of bioactive molecules from CuAAC click-chemistry-based combinatorial libraries.

Peng Zhan, Xinyong Liu, Xueshun Wang, 2016, Drug discovery today.

1,3,4-oxadiazole: a privileged structure in antiviral agents.

P. Zhan, Xinyong Liu, Zhenyu Li, 2011, Mini reviews in medicinal chemistry.

Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors.

Peng Zhan, Xuwang Chen, Christophe Pannecouque, 2012, Bioorganic & medicinal chemistry.

{2-Hydroxy-N′-[1-(2-oxidophenyl)ethylidene]benzohydrazidato}morpholinecopper(II)

P. Zhan, R. Jia, Yanlin Yuan, 2009, Acta Crystallographica Section E.

Designed multiple ligands: an emerging anti-HIV drug discovery paradigm.

Peng Zhan, P. Zhan, Xinyong Liu, 2009, Current pharmaceutical design.

Design, Synthesis and Structure—Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Molecules.

Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, European journal of medicinal chemistry.

Contemporary medicinal-chemistry strategies for the discovery of selective butyrylcholinesterase inhibitors.

Dongwei Kang, P. Zhan, Xinyong Liu, 2019, Drug discovery today.

Functional roles of azoles motif in anti-HIV agents.

E. De Clercq, P. Zhan, Xinyong Liu, 2011, Current medicinal chemistry.

Cosalane and its analogues: a unique class of anti-HIV agents.

P. Zhan, Xinyong Liu, Zhenyu Li, 2010, Mini reviews in medicinal chemistry.

A New Convenient Method for the Synthesis of Formyl Ferrocene with Triethyl Orthoformate and A1C13

P. Zhan, Jie Tang, Xiao-feng Liu, 2000 .

An improved synthesis approach of the HIV-1 inhibitor RDEA427, a pyrrolo[2,3-d]pyrimidine derivative

Dongwei Kang, Boshi Huang, P. Zhan, 2016 .

Privileged scaffolds or promiscuous binders: a glance of pyrrolo[2,1-f][1,2,4]triazines and related bridgehead nitrogen heterocycles in medicinal chemistry.

P. Zhan, Xinyong Liu, Yu'ning Song, 2013, Current pharmaceutical design.

Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-acetamides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, Zengjun Fang, C. Pannecouque, 2009, European journal of medicinal chemistry.

Novel 1,2,3-thiadiazole derivatives as HIV-1 NNRTIs with improved potency: Synthesis and preliminary SAR studies.

Zengjun Fang, C. Pannecouque, P. Zhan, 2009, Bioorganic & Medicinal Chemistry.

1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, P. Zhan, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and Preliminary Biologic Evaluation of 5‐Substituted‐2‐(4‐substituted phenyl)‐1,3‐Benzoxazoles as A Novel Class of Influenza Virus A Inhibitors

E. De Clercq, L. Naesens, P. Zhan, 2012, Chemical biology & drug design.

Recent progress in the structural modification and pharmacological activities of ligustrazine derivatives.

P. Zhan, Xinyong Liu, Ping Gao, 2018, European journal of medicinal chemistry.

Recent advances in antiviral activity of benzo/heterothiadiazine dioxide derivatives.

Peng Zhan, E. De Clercq, P. Zhan, 2008, Current medicinal chemistry.

Sulfanyltriazole/tetrazoles: a promising class of HIV-1 NNRTIs.

Peng Zhan, E. De Clercq, P. Zhan, 2009, Mini reviews in medicinal chemistry.

Design, synthesis, and biological evaluation of piperidinyl‐substituted [1,2,4]triazolo[1,5‐a]pyrimidine derivatives as potential anti‐HIV‐1 agents with reduced cytotoxicity

E. De Clercq, Dongwei Kang, Boshi Huang, 2020, Chemical biology & drug design.

Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs.

Peng Zhan, Ye Tian, Xuwang Chen, 2012, Bioorganic & medicinal chemistry letters.

1,2,3-Selenadiazole thioacetanilides: synthesis and anti-HIV activity evaluation.

E. De Clercq, Zengjun Fang, C. Pannecouque, 2009, Bioorganic & medicinal chemistry.

Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives.

Peng Zhan, Ye Tian, Christophe Pannecouque, 2014, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of novel 5-alkyl-2-arylthio-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Peng Zhan, Jing Zhang, Christophe Pannecouque, 2011, Bioorganic & medicinal chemistry.

Arylazolyl(azinyl)thioacetanilides. Part 16: Structure-based bioisosterism design, synthesis and biological evaluation of novel pyrimidinylthioacetanilides as potent HIV-1 inhibitors.

Peng Zhan, Jan Balzarini, Christophe Pannecouque, 2014, Bioorganic & medicinal chemistry.

Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2019, Organic & biomolecular chemistry.

Facile Synthesis of Derivatives of 1,1,3‐Trioxo‐2H,4H‐pyrrolo[1,2‐b][1,2,4,6]thiatriazine: A New Heterocyclic System

Peng Zhan, Boshi Huang, Boshi Huang, 2013 .

Heterocycle-thioacetic acid motif: a privileged molecular scaffold with potent, broad-ranging pharmacological activities.

Peng Zhan, Yu'ning Song, P. Zhan, 2013, Current pharmaceutical design.

Discovery of novel anti-HIV agents via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry-based approach

Peng Zhan, P. Zhan, Xinyong Liu, 2016, Expert opinion on drug discovery.

Medicinal chemistry insights into novel CDC25 inhibitors.

P. Zhan, Xinyong Liu, Yu'ning Song, 2020, European journal of medicinal chemistry.

1,2,3‐Thiadiazole Thioacetanilides. Part 2

C. Pannecouque, P. Zhan, Zhen-Yu Li, 2010, Chemistry & biodiversity.

Ligustrazine Derivatives. Part 4: Design, Synthesis, and Biological Evaluation of Novel Ligustrazine‐based Stilbene Derivatives as Potential Cardiovascular Agents

P. Zhan, Xinyong Liu, Yu'ning Song, 2012, Chemical biology & drug design.

The current progress in the use of boron as a platform for novel antiviral drug design

Shuo Wang, P. Zhan, Xinyong Liu, 2022, Expert opinion on drug discovery.

Morphology and Properties of Thermoplastic Sugar Beet Pulp and Poly(butylene adipate-co-terepthalate) Blends

P. Zhan, Linshu Liu, Long Jiang, 2011 .

Synthesis and anti-HIV activity evaluation of novel N′-arylidene-2-[1-(naphthalen-1-yl)-1H-tetrazol-5-ylthio]acetohydrazides

C. Pannecouque, P. Zhan, Xinyong Liu, 2010, Medicinal Chemistry Research.

Arylazolylthioacetanilide. Part 11: design, synthesis and biological evaluation of 1,2,4-triazole thioacetanilide derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

C. Pannecouque, P. Zhan, Xinyong Liu, 2013, Medicinal chemistry (Shariqah (United Arab Emirates)).

Discovery of novel pyridazinylthioacetamides as potent HIV-1 NNRTIs using a structure-based bioisosterism approach

Peng Zhan, Erik De Clercq, Ye Tian, 2013 .

Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach.

Peng Zhan, Erik De Clercq, Ye Tian, 2012, Bioorganic & medicinal chemistry.

Arylazolyl(azinyl)thioacetanilides. Part 10: design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors.

Peng Zhan, Jan Balzarini, Xuwang Chen, 2012, Bioorganic & medicinal chemistry.

Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents

E. De Clercq, C. Pannecouque, L. Naesens, 2012, Archives of Pharmacal Research.

Arylazolylthioacetanilide. Part 8: Design, synthesis and biological evaluation of novel 2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)-N-arylacetamides as potent HIV-1 inhibitors.

E. De Clercq, C. Pannecouque, P. Zhan, 2011, European journal of medicinal chemistry.

Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2005 – 2010)

Peng Zhan, P. Zhan, Xinyong Liu, 2011, Expert opinion on therapeutic patents.

Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV‐1 RNase H inhibitors

Peng Zhan, Jacob Kongsted, Luis Menéndez-Arias, 2019, Chemical biology & drug design.

Rationally designed multitarget anti-HIV agents.

X Liu, P Zhan, P. Zhan, 2013, Current medicinal chemistry.

First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain.

E. De Clercq, Dongwei Kang, Boshi Huang, 2018, Bioorganic & medicinal chemistry letters.

"Old Dogs with New Tricks": exploiting alternative mechanisms of action and new drug design strategies for clinically validated HIV targets.

Peng Zhan, Dongwei Kang, Yu'ning Song, 2014, Molecular bioSystems.

5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase.

Peng Zhan, Xiao Ding, Luis Menéndez-Arias, 2018, European journal of medicinal chemistry.

Recent progress in the research of small molecule HIV-1 RNase H inhibitors.

E. De Clercq, P. Zhan, Xinyong Liu, 2014, Current medicinal chemistry.

Exosomes from human adipose‐derived stem cells promote sciatic nerve regeneration via optimizing Schwann cell function

P. Zhan, Jing Chen, Zhenbing Chen, 2019, Journal of cellular physiology.

Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2021, Acta Pharmaceutica Sinica B.

Search, Identification, and Design of Effective Antiviral Drugs Against Pandemic Human Coronaviruses.

Dongwei Kang, P. Zhan, Xinyong Liu, 2021, Advances in experimental medicine and biology.

Recent advances in DAPYs and related analogues as HIV-1 NNRTIs.

E. De Clercq, P. Zhan, Xinyong Liu, 2011, Current medicinal chemistry.

Novel urate transporter 1 (URAT1) inhibitors: a review of recent patent literature (2016–2019)

Dongwei Kang, P. Zhan, Xinyong Liu, 2019, Expert opinion on therapeutic patents.

Molecular design opportunities presented by solvent‐exposed regions of target proteins

Peng Zhan, Erik De Clercq, Yuning Song, 2019, Medicinal research reviews.

Design, synthesis, and antiviral evaluation of novel hydrazone‐substituted thiophene[3,2‐d]pyrimidine derivatives as potent human immunodeficiency virus‐1 inhibitors

E. De Clercq, Dongwei Kang, C. Pannecouque, 2018, Chemical biology & drug design.

New techniques and strategies in drug discovery

Guan Wang, Zhen Zhang, Jing Guo, 2020, Chinese Chemical Letters.

The development of an effective synthetic route of rilpivirine

Dongwei Kang, P. Zhan, Xinyong Liu, 2021, BMC Chemistry.

Novel indolylarylsulfone derivatives as covalent HIV-1 reverse transcriptase inhibitors specifically targeting the drug-resistant mutant Y181C.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase.

E. De Clercq, C. Pannecouque, P. Zhan, 2019, Bioorganic & medicinal chemistry.

1-Hydroxypyrido[2,3-d]pyrimidin-2(1H)-ones as novel selective HIV integrase inhibitors obtained via privileged substructure-based compound libraries.

Lingzi Zhang, C. Pannecouque, P. Zhan, 2017, Bioorganic & medicinal chemistry.

Design, synthesis and evaluation of pyrazole derivatives as non-nucleoside hepatitis B virus inhibitors.

P. Zhan, Xinyong Liu, Chunhong Ma, 2016, European journal of medicinal chemistry.

Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs

E. De Clercq, Dongwei Kang, Boshi Huang, 2019, Acta pharmaceutica Sinica. B.

Synthesis, drug release and anti-HIV activity of a series of PEGylated zidovudine conjugates.

E. De Clercq, C. Pannecouque, P. Zhan, 2012, International journal of biological macromolecules.

First discovery of novel 3-hydroxy-quinazoline-2,4(1H,3H)-diones as specific anti-vaccinia and adenovirus agents via ‘privileged scaffold’ refining approach

Peng Zhan, Lieve Naesens, Heng Zhang, 2016, Bioorganic & Medicinal Chemistry Letters.

Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators.

P. Zhan, Yukihiro Itoh, Miki Suzuki, 2016, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of "Multi-Site"-binding influenza virus neuraminidase inhibitors.

P. Zhan, Xinyong Liu, Xiao Ding, 2019, European journal of medicinal chemistry.

Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant.

Peng Zhan, Xiao Ding, Ye Tian, 2018, Journal of medicinal chemistry.

Medicinal chemistry insights in the discovery of novel LSD1 inhibitors.

Peng Zhan, Xueshun Wang, Takayoshi Suzuki, 2015, Epigenomics.

TSG101: a novel anti-HIV-1 drug target.

E. De Clercq, P. Zhan, Xinyong Liu, 2010, Current medicinal chemistry.

Recent applications of click chemistry in drug discovery

Peng Zhan, Dongwei Kang, Xinyong Liu, 2019, Expert opinion on drug discovery.

The Medicinal Chemistry of Zika Virus

P. Zhan, Xinyong Liu, Letícia Anderson, 2021 .

MMP11 promotes the proliferation and progression of breast cancer through stabilizing Smad2 protein

P. Zhan, Xiang Li, G. Pi, 2021, Oncology reports.

Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity

P. Zhan, Yukihiro Itoh, Takayoshi Suzuki, 2013, Journal of medicinal chemistry.

Design, synthesis and anti-HIV evaluation of novel diarylnicotinamide derivatives (DANAs) targeting the entrance channel of the NNRTI binding pocket through structure-guided molecular hybridization.

Peng Zhan, Christophe Pannecouque, E. De Clercq, 2014, European journal of medicinal chemistry.

Metabolite Identification of HIV-1 Capsid Modulators PF74 and 11L in Human Liver Microsomes

P. Zhan, Xinyong Liu, Lin Sun, 2022, Metabolites.

Design, synthesis, and evaluation of novel heteroaryldihydropyrimidine derivatives as non‐nucleoside hepatitis B virus inhibitors by exploring the solvent‐exposed region

P. Zhan, Xinyong Liu, Xiao Ding, 2020, Chemical biology & drug design.

Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators

E. De Clercq, C. Pannecouque, P. Zhan, 2022, Molecules.

Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, European journal of medicinal chemistry.

From design to biological mechanism evaluation of phenylalanine-bearing HIV-1 capsid inhibitors targeting a vital assembly interface

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Chinese Chemical Letters.

Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities.

P. Zhan, Xinyong Liu, Chin-Ho Chen, 2020, European journal of medicinal chemistry.

Design, synthesis, and antiviral evaluation of novel piperidine-substituted arylpyrimidines as HIV-1 NNRTIs by exploring the hydrophobic channel of NNIBP.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Bioorganic chemistry.

Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies.

E. De Clercq, Dongwei Kang, Boshi Huang, 2021, Journal of medicinal chemistry.

Discovery, optimization, and target identification of novel coumarin derivatives as HIV-1 reverse transcriptase-associated ribonuclease H inhibitors.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, European journal of medicinal chemistry.

Discovery of potent HIV‐1 non‐nucleoside reverse transcriptase inhibitors by exploring the structure–activity relationship of solvent‐exposed regions I

E. De Clercq, Dongwei Kang, C. Pannecouque, 2019, Chemical biology & drug design.

Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles.

Peng Zhan, F. J. Luque, Ye Tian, 2019, Journal of medicinal chemistry.

Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties.

Peng Zhan, Jian Zhang, F. J. Luque, 2019, Journal of medicinal chemistry.

Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors

T. Steitz, Dongwei Kang, C. Pannecouque, 2018, eLife.

Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives as potent HIV-1 NNRTIs.

E. De Clercq, Dongwei Kang, Boshi Huang, 2017, European journal of medicinal chemistry.

Contemporary medicinal chemistry strategies for the discovery and optimization of influenza inhibitors targeting vRNP constituent proteins

P. Zhan, Xinyong Liu, A. Loregian, 2021, Acta pharmaceutica Sinica. B.

Identification of Novel Diarylpyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors by Exploring the Primer Grip Region

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Pharmaceuticals.

Current drug research on PEGylation with small molecular agents

Peng Zhan, Erik De Clercq, P. Zhan, 2013 .

Recent advances in the structure-based rational design of TNKSIs.

Peng Zhan, Takayoshi Suzuki, Yukihiro Itoh, 2014, Molecular bioSystems.

Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors.

P. Zhan, Xinyong Liu, S. Cherukupalli, 2020, European journal of medicinal chemistry.

Drug repurposing: An effective strategy to accelerate contemporary drug discovery

P. Zhan, L. Ouyang, Bin Yu, 2022, Drug Discovery Today.

Design, synthesis and evaluation of heteroaryldihydropyrimidine analogues bearing spiro ring as hepatitis B virus capsid protein inhibitors.

P. Zhan, Xinyong Liu, J. Tavis, 2021, European journal of medicinal chemistry.

Efficient drug discovery by rational lead hybridization based on crystallographic overlay.

Jian Zhang, Peng Zhan, Shuo Zhang, 2019, Drug discovery today.

Discovery of nitropyridine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors via a structure-based core refining approach.

Peng Zhan, Christophe Pannecouque, E. De Clercq, 2014, European journal of medicinal chemistry.

Discovery of novel diarylpyrimidines as potent HIV NNRTIs via a structure-guided core-refining approach.

Peng Zhan, Jan Balzarini, Ye Tian, 2014, European journal of medicinal chemistry.

Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles.

Peng Zhan, Xiao Ding, Dongwei Kang, 2016, Journal of medicinal chemistry.

Microvesicles from human adipose stem cells promote wound healing by optimizing cellular functions via AKT and ERK signaling pathways

P. Zhan, Jing Chen, Zhenbing Chen, 2019, Stem Cell Research & Therapy.

Novel urate transporter 1 (URAT1) inhibitors: a review of recent patent literature (2020–present)

P. Zhan, Xinyong Liu, E. D. da Silva-Júnior, 2022, Expert opinion on therapeutic patents.

Design, synthesis and biological evaluation of 3-benzyloxy-linked pyrimidinylphenylamine derivatives as potent HIV-1 NNRTIs.

E. De Clercq, C. Pannecouque, P. Zhan, 2013, Bioorganic & medicinal chemistry.

Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors' Binding Pocket.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, Journal of medicinal chemistry.

Sulforaphane is a reversible covalent inhibitor of 3‐chymotrypsin‐like protease of SARS‐CoV‐2

P. Zhan, Lijun Rong, Ruikun Du, 2023, Journal of medical virology.

Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Molecules.

Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitors.

Dongwei Kang, P. Zhan, Xinyong Liu, 2021, Bioorganic & medicinal chemistry.

Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, International Journal of Molecular Sciences.

Discovery of novel 1,2,4‐triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Journal of medical virology.

Structure-Based Discovery and Characterization of a Preclinical Drug Candidate for the Treatment of HIV-1 Infection

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Viruses.

Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants.

Peng Zhan, Xiao Ding, Ye Tian, 2017, Journal of medicinal chemistry.

Update on Recent Developments in Small Molecular HIV-1 RNase H Inhibitors (2013-2016): Opportunities and Challenges.

P. Zhan, Xinyong Liu, L. Menéndez-Arias, 2018, Current medicinal chemistry.

Recent advances in the research of HIV-1 RNase H inhibitors.

E. De Clercq, P. Zhan, Xinyong Liu, 2008, Mini reviews in medicinal chemistry.

Discovery of novel "Dual-site" binding oseltamivir derivatives as potent influenza virus neuraminidase inhibitors.

P. Zhan, Xinyong Liu, Waleed A Zalloum, 2020, European journal of medicinal chemistry.

Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.

Peng Zhan, Xiao Ding, Ye Tian, 2018, Journal of medicinal chemistry.

Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2011 – 2014)

Peng Zhan, Ye Tian, Xinyong Liu, 2014, Expert opinion on therapeutic patents.

Ligustrazine derivatives. Part 5: design, synthesis and biological evaluation of novel ligustrazinyloxy-cinnamic acid derivatives as potent cardiovascular agents.

P. Zhan, Xinyong Liu, Hong-fei Chen, 2011, European journal of medicinal chemistry.

Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies.

Dongwei Kang, P. Zhan, Xinyong Liu, 2023, Bioorganic chemistry.

Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2019, RSC advances.

Design, Synthesis, and Biological Evaluation of Novel 3,5‐Disubstituted‐1,2,6‐Thiadiazine‐1,1‐Dione Derivatives as HIV‐1 NNRTIs

Peng Zhan, Jan Balzarini, Ye Tian, 2013, Chemical biology & drug design.

Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, Acta pharmaceutica Sinica. B.

Chemical space exploration around indolylarylsulfone scaffold led to a novel class of highly active HIV-1 NNRTIs with spiro structural features.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, European journal of medicinal chemistry.

GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy

P. Zhan, Hong Liu, Wei-xue Tang, 2023, Acta Pharmacologica Sinica.

Computer-aided drug design in seeking viral capsid modulators.

P. Zhan, Xinyong Liu, Xujie Zhang, 2023, Drug discovery today.

Design, synthesis, and biological evaluation of novel 5‐Alkyl‐6‐Adamantylmethylpyrimidin‐4(3H)‐ones as HIV‐1 non‐nucleoside reverse‐transcriptase inhibitors

E. De Clercq, Dongwei Kang, Boshi Huang, 2016, Chemical biology & drug design.

Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors.

Peng Zhan, Jan Balzarini, Xuwang Chen, 2012, European journal of medicinal chemistry.

Synthesis and Biological Evaluation of a Series of 2‐((1‐substituted‐1H‐1,2,3‐triazol‐4‐yl)methylthio)‐6‐(naphthalen‐1‐ylmethyl)pyrimidin‐4(3H)‐one As Potential HIV‐1 Inhibitors

Peng Zhan, Dongwei Kang, Christophe Pannecouque, 2015, Chemical biology & drug design.

Design, synthesis and biological evaluation of substituted guanidine indole derivatives as potential inhibitors of HIV-1 Tat-TAR interaction.

E. De Clercq, C. Pannecouque, P. Zhan, 2013, Medicinal chemistry (Shariqah (United Arab Emirates)).

Novel RNase H inhibitors blocking RNA-directed strand displacement DNA synthesis by HIV-1 reverse transcriptase.

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Journal of molecular biology.

3D-QSAR analysis of a series of S-DABO derivatives as anti-HIV agents by CoMFA and CoMSIA

P. Zhan, Hu Xu, L. Fu, 2016, SAR and QSAR in environmental research.

Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Journal of medicinal chemistry.

Long non-coding RNAs RP5-821D11.7, APCDD1L-AS1 and RP11-277P12.9 were associated with the prognosis of lung squamous cell carcinoma

Zhou Wang, P. Zhan, Xiaofeng Zhu, 2018, Molecular medicine reports.

Retroviral restriction factors TRIM5α: therapeutic strategy to inhibit HIV-1 replication.

E. De Clercq, P. Zhan, Xinyong Liu, 2011, Current medicinal chemistry.

Design, Synthesis, and Anti‐HIV Evaluation of Novel Triazine Derivatives Targeting the Entrance Channel of the NNRTI Binding Pocket

E. De Clercq, Huiqing Liu, C. Pannecouque, 2015, Chemical biology & drug design.

MDA19, a novel CB2 agonist, inhibits hepatocellular carcinoma partly through inactivation of AKT signaling pathway

P. Zhan, Mei-Chun Rao, Dongfeng Chen, 2019, Biology Direct.

Combination of 2D and 3D-QSAR studies on DAPY and DANA derivatives as potent HIV-1 NNRTIs

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Journal of Molecular Structure.

3D-QSAR and docking studies on piperidine-substituted diarylpyrimidine analogues as HIV-1 reverse transcriptase inhibitors

Lingzi Zhang, P. Zhan, Xinyong Liu, 2015, Medicinal Chemistry Research.

Medicinal chemistry strategies in the discovery and optimization of HBV core protein allosteric modulators (2018–2022 update)

P. Zhan, Xinyong Liu, Shujing Xu, 2023, Chinese Chemical Letters.

Review of small synthetic molecules targeting HBV capsid assembly.

P. Zhan, Xinyong Liu, Na Liu, 2015, Medicinal chemistry (Shariqah (United Arab Emirates)).

Design, synthesis and biological evaluation of novel ligustrazinylated derivatives as potent cardiovascular agents

P. Zhan, Xinyong Liu, Hong-fei Chen, 2013 .

Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 2: discovery of novel [1,2,4]Triazolo[1,5-a]pyrimidines using a structure-guided core-refining approach.

Peng Zhan, Ye Tian, Christophe Pannecouque, 2014, European journal of medicinal chemistry.

Discovery of small molecular inhibitors targeting HIV-1 gp120-CD4 interaction drived from BMS-378806.

E. De Clercq, Boshi Huang, P. Zhan, 2014, European journal of medicinal chemistry.

Downregulation of the Ca2+‐activated K+ channel KC a3.1 by histone deacetylase inhibition in human breast cancer cells

P. Zhan, Takayoshi Suzuki, K. Muraki, 2016, Pharmacology research & perspectives.

Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library.

Fangfang Zhang, Peng Zhan, Ye Tian, 2018, European journal of medicinal chemistry.

Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, RSC medicinal chemistry.

Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines.

E. De Clercq, Boshi Huang, Huiqing Liu, 2015, European journal of medicinal chemistry.

Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents

C. Pannecouque, L. Naesens, P. Zhan, 2012, Archives of pharmacal research.

Identification of Highly Selective and Potent Histone Deacetylase 3 Inhibitors Using Click Chemistry-Based Combinatorial Fragment Assembly

Takashi Okamoto, Peng Zhan, Takayoshi Suzuki, 2013, PloS one.

Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket.

E. De Clercq, Dongwei Kang, Boshi Huang, 2016, European journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Novel 2‐(Pyridin‐3‐yloxy)acetamide Derivatives as Potential Anti‐HIV‐1 Agents

E. De Clercq, Boshi Huang, C. Pannecouque, 2016, Chemical biology & drug design.

Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs.

Peng Zhan, Jan Balzarini, Xuwang Chen, 2014, Bioorganic & medicinal chemistry.

Design, Synthesis and Anti-HIV-1 Evaluation of Novel Arylazolylthioacetanilides as Potent NNRTIS

C. Pannecouque, P. Zhan, Xinyong Liu, 2009 .

The nucleotide receptor STING translocates to the phagosomes to negatively regulate anti-fungal immunity.

P. Zhan, Y. Zheng, Chengjiang Gao, 2023, Immunity.

Inhibition of CDC25B With WG-391D Impedes the Tumorigenesis of Ovarian Cancer

P. Zhan, Yihua Chen, Yu'ning Song, 2019, Front. Oncol..

Discovery of ligustrazine and chalcone derivatives as novel viral nucleoprotein nuclear export inhibitors against influenza viruses

Dongwei Kang, P. Zhan, Xinyong Liu, 2023, Journal of medical virology.

Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators.

Peng Zhan, Yukihiro Itoh, Takayoshi Suzuki, 2015, Journal of medicinal chemistry.

Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs.

Peng Zhan, Jan Balzarini, Christophe Pannecouque, 2013, Bioorganic & medicinal chemistry.

Structural optimization of pyridine-type DAPY derivatives to exploit the tolerant regions of the NNRTI binding pocket.

E. De Clercq, Boshi Huang, C. Pannecouque, 2016, European journal of medicinal chemistry.

Discovery of novel anti-influenza agents via contemporary medicinal chemistry strategies (2014-2018 update).

Dongwei Kang, Zengjun Fang, P. Zhan, 2019, Future medicinal chemistry.

Recent advances in the molecular design and applications of proteolysis targeting chimera-based multi-specific antiviral modality

P. Zhan, Xinyong Liu, L. Menéndez-Arias, 2023, Acta Materia Medica.

[Research progress of dual inhibitors targeting HIV-1 reverse transcriptase and integrase].

P. Zhan, H. Liu, Xin‐yong Liu, 2013, Yao xue xue bao = Acta pharmaceutica Sinica.

Microvesicles from human adipose stem cells promote wound healing by optimizing cellular functions via AKT and ERK signaling pathways

P. Zhan, Jing Chen, Zhenbing Chen, 2019, Stem Cell Research & Therapy.

Author response: Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors

T. Steitz, Dongwei Kang, C. Pannecouque, 2018 .

Discovery of potent and selective Cdc25 phosphatase inhibitors via rapid assembly and in situ screening of Quinonoid-focused libraries.

P. Zhan, Xinyong Liu, Yu'ning Song, 2021, Bioorganic chemistry (Print).

Medicinal chemistry strategies towards the development of non-covalent SARS-CoV-2 Mpro inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2023, Acta pharmaceutica Sinica. B.

Identification of Boronate-Containing Diarylpyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

Dongwei Kang, C. Pannecouque, P. Zhan, 2022, Molecules.

Design, Synthesis, and Acetylcholinesterase Inhibition Assay of Novel 9-(1-(Substituted-benzyl)piperidin-4-yl)-2-chloro-9H-purin-6-amine Derivatives

Dongwei Kang, P. Zhan, Xinyong Liu, 2013 .

Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors

T. Steitz, Dongwei Kang, C. Pannecouque, 2018, eLife.

Discovery of novel DAPY-IAS hybrid derivatives as potential HIV-1 inhibitors using molecular hybridization based on crystallographic overlays.

Peng Zhan, Xueshun Wang, Christophe Pannecouque, 2017, Bioorganic & medicinal chemistry.

Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization.

Peng Zhan, Ye Tian, Dongwei Kang, 2017, European journal of medicinal chemistry.

Targeting hepatitis B virus cccDNA levels: recent progress in seeking small molecule drug candidates.

Shuo Wang, P. Zhan, Xinyong Liu, 2023, Drug discovery today.

Discovery of nitropyridine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors via a structure-based core refining approach.

E. De Clercq, Huiqing Liu, C. Pannecouque, 2014, European journal of medicinal chemistry.

5-Cyano substituted diarylpyridines as potent HIV-1 NNRTIs: Rational design, synthesis, and activity evaluation.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, European journal of medicinal chemistry.

Novel diaryltriazines with a picolinonitrile moiety as potent HIV-1 RT inhibitors: a patent evaluation of WO2016059647(A2)

Dongwei Kang, Boshi Huang, P. Zhan, 2017, Expert opinion on therapeutic patents.

Emerging drug design strategies in anti-influenza drug discovery

P. Zhan, Xinyong Liu, L. Menéndez-Arias, 2023, Acta pharmaceutica Sinica. B.

1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, P. Zhan, 2008, Bioorganic & medicinal chemistry letters.

Design, synthesis and evaluation of pyrazole derivatives as non-nucleoside hepatitis B virus inhibitors.

P. Zhan, Xinyong Liu, Chunhong Ma, 2016, European journal of medicinal chemistry.

Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors

E. De Clercq, Dongwei Kang, Boshi Huang, 2023, Communications chemistry.

Design, Synthesis, and Anti‐HIV Evaluation of Novel Triazine Derivatives Targeting the Entrance Channel of the NNRTI Binding Pocket

E. De Clercq, Huiqing Liu, C. Pannecouque, 2015, Chemical biology & drug design.

Development of chalcone-like derivatives and their biological and mechanistic investigations as novel influenza nuclear export inhibitors.

P. Zhan, Xinyong Liu, P. Kar, 2023, European journal of medicinal chemistry.

Sulfonic acid: key drug design elements with potent, broad-ranging pharmacological activities.

P. Zhan, Xinyong Liu, E. D. da Silva-Júnior, 2023, Future medicinal chemistry.

A novel N-heterocycles substituted oseltamivir derivatives as potent inhibitors of influenza virus neuraminidase: discovery, synthesis and biological evaluation

P. Zhan, Xinyong Liu, A. Loregian, 2023, Journal of enzyme inhibition and medicinal chemistry.

Escaping from Flatland: Multiparameter Optimization Leads to the Discovery of Novel Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Human Immunodeficiency Virus-1 Non-nucleoside Reverse Transcriptase Inhibitors with Superior Antiviral Activities against Non-nucleoside Reverse Transcriptase Inhibito

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, Journal of medicinal chemistry.

Identification of a small-molecule Tim-3 inhibitor to potentiate T cell–mediated antitumor immunotherapy in preclinical mouse models

P. Zhan, Xinyong Liu, Xuetian Yue, 2023, Science Translational Medicine.

Advances in drug structure-activity-relationships for the development of selenium-based compounds against HIV

P. Zhan, Xinyong Liu, Xiangyi Jiang, 2023, Expert opinion on drug discovery.

Identification of the Imidazo[1,2-a]pyrazine Derivative A4 as a Potential Influenza Virus Nucleoprotein Inhibitor.

P. Zhan, Xinyong Liu, Lijun Rong, 2023, ACS pharmacology & translational science.

Increased Siglec-9/Siglec-9L interactions on NK cells predict poor HCC prognosis and present a targetable checkpoint for immunotherapy.

P. Zhan, Xinyong Liu, Zhuanchang Wu, 2024, Journal of hepatology.

Pyrazolo[1,5-a]pyrimidine-based macrocycles as novel HIV-1 inhibitors: a patent evaluation of WO2015123182

P. Zhan, Xinyong Liu, Lin Sun, 2016, Expert opinion on therapeutic patents.

Multifunctional agents against Alzheimer's disease based on oxidative stress: Polysubstituted pyrazine derivatives synthesized by multicomponent reactions.

Dongwei Kang, P. Zhan, Xinyong Liu, 2023, Bioorganic & medicinal chemistry.

Recent advances in the research of 2,3-diaryl-1,3-thiazolidin-4-one derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, P. Zhan, Xinyong Liu, 2012, Current medicinal chemistry.

Discovery of novel fused-heterocycle-bearing diarypyrimidine derivatives as HIV-1 potent NNRTIs targeting tolerant region I for enhanced antiviral activity and resistance profile.

Boshi Huang, C. Pannecouque, P. Zhan, 2024, European journal of medicinal chemistry.

Structure-based design, synthesis, and biological characterization of indolylarylsulfone derivatives as novel human immunodeficiency virus type 1 inhibitors with potent antiviral activities and favorable drug-like profiles.

Dongwei Kang, C. Pannecouque, P. Zhan, 2024, Journal of medical virology.

Discovery of 2,4,6-trisubstituted Pyrimidine Derivatives as Novel Potent HIV-1 NNRTIs by Exploiting the Tolerant Region II of the NNIBP

Dongwei Kang, C. Pannecouque, P. Zhan, 2024, European Journal of Medicinal Chemistry.

Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants

Dongwei Kang, C. Pannecouque, P. Zhan, 2023, Acta pharmaceutica Sinica. B.

Identification of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase.

Dongwei Kang, C. Pannecouque, P. Zhan, 2022, European journal of medicinal chemistry.