S. Douthwaite

S. Douthwaite, 2001, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

The structural basis of macrolide-ribosome binding assessed using mutagenesis of 23S rRNA positions 2058 and 2059.

J. Poehlsgaard, S. Douthwaite, N. Ban, 2004, Journal of molecular biology.

The hyperthermophilic partners Nanoarchaeum and Ignicoccus stabilize their tRNA T-loops via different but structurally equivalent modifications

S. Douthwaite, S. Auxilien, H. Huber, 2020, Nucleic acids research.

Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy

S. Douthwaite, Mingfu Liu, 2002, Proceedings of the National Academy of Sciences of the United States of America.

The antibiotics micrococcin and thiostrepton interact directly with 23S rRNA nucleotides 1067A and 1095A.

S. Douthwaite, G. Rosendahl, 1994, Nucleic acids research.

Virulence properties of Campylobacter jejuni are enhanced by displaying a mycobacterial TlyA methylation pattern in its rRNA

S. Douthwaite, P. Bącal, A. Sałamaszyńska-Guz, 2020, Cellular microbiology.

Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs.

S. Douthwaite, B. Plikaytis, Courtney E. Maus, 2006, Molecular cell.

Binding site of ribosomal proteins on prokaryotic 5S ribonucleic acids: a study with ribonucleases.

R. Garrett, S. Douthwaite, A. Christensen, 1982, Biochemistry.

A "bulged" double helix in a RNA-protein contact site.

H. Noller, R. Garrett, S. Douthwaite, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of the binding sites of protein L11 and the L10.(L12)4 pentameric complex in the GTPase domain of 23 S ribosomal RNA from Escherichia coli.

R. Garrett, S. Douthwaite, A. Liljas, 1990, Journal of molecular biology.

Oxazolidinone Resistance Mutations in 23S rRNA ofEscherichia coli Reveal the Central Region of Domain V as the Primary Site of Drug Action

S. Douthwaite, A. Mankin, S. Swaney, 2000, Journal of bacteriology.

LNAzymes: incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage.

S. Douthwaite, J. Wengel, B. Vester, 2002, Journal of the American Chemical Society.

Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram‐negative from Gram‐positive bacteria

S. Douthwaite, Mingfu Liu, 2002, Molecular microbiology.

Tandem DNA‐bound cAMP‐CRP complexes are required for transcriptional repression of the deoP2 promoter by the CytR repressor in Escherichia coli

S. Douthwaite, P. Valentin-Hansen, L Sogaard-Andersen, 1990, Molecular microbiology.

Nucleotide methylations in rRNA that confer resistance to ribosome-targeting antibiotics

S. Douthwaite, D. Fourmy, S. Yoshizawa, 2005 .

The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose

S. Douthwaite, F. Kirpekar, L. Jakobsen, 2003, Molecular microbiology.

Campylobacter jejuni Virulence Factors Identified by Modulating Their Synthesis on Ribosomes With Altered rRNA Methylation

S. Douthwaite, A. Sałamaszyńska-Guz, M. Murawska, 2022, Frontiers in Cellular and Infection Microbiology.

Structure and role of 5S RNA-protein complexes in protein biosynthesis

H. Noller, R. Garrett, S. Douthwaite, 1981 .

Archease from Pyrococcus abyssi Improves Substrate Specificity and Solubility of a tRNA m5C Methyltransferase*

S. Douthwaite, S. Auxilien, H. Grosjean, 2007, Journal of Biological Chemistry.

The CytR repressor antagonizes cyclic AMP-cyclic AMP receptor protein activation of the deoCp2 promoter of Escherichia coli K-12

S. Douthwaite, P. Valentin-Hansen, J. Martinussen, 1990, Journal of bacteriology.

A single methyltransferase YefA (RlmCD) catalyses both m5U747 and m5U1939 modifications in Bacillus subtilis 23S rRNA

S. Douthwaite, C. Fabret, D. Brégeon, 2011, Nucleic acids research.

Specificity shifts in the rRNA and tRNA nucleotide targets of archaeal and bacterial m5U methyltransferases.

S. Douthwaite, D. Fourmy, S. Auxilien, 2011, RNA.

YibK is the 2'-O-methyltransferase TrmL that modifies the wobble nucleotide in Escherichia coli tRNA(Leu) isoacceptors.

S. Douthwaite, T. Gabaldón, A. Benítez-Páez, 2010, RNA.

YibK is the 2 9-O-methyltransferase TrmL that modifies the wobble nucleotide in Escherichia coli tRNALeu isoacceptors

S. Douthwaite, T. Gabaldón, A. Benítez-Páez, 2010 .

Identifying the methyltransferases for m5U747 and m5U1939 in 23S rRNA using MALDI mass spectrometry

S. Douthwaite, F. Kirpekar, C. T. Madsen, 2003 .

The macrolide binding site on the bacterial ribosome.

J. Poehlsgaard, S. Douthwaite, 2002, Current drug targets. Infectious disorders.

Visualizing the 16-membered ring macrolides tildipirosin and tilmicosin bound to their ribosomal site.

J. Poehlsgaard, S. Douthwaite, R. Warrass, 2012, ACS chemical biology.

Ketolide Antimicrobial Activity Persists after Disruption of Interactions with Domain II of 23S rRNA

J. Poehlsgaard, S. Douthwaite, L. Jakobsen, 2004, Antimicrobial Agents and Chemotherapy.

YibK is the 29-O-methyltransferase TrmL that modifies the wobble nucleotide inEscherichia coli

S. Douthwaite, M. Villarroya, E. Armengod, 2010 .

The flavoprotein Mcap0476 (RlmFO) catalyzes m5U1939 modification in Mycoplasma capricolum 23S rRNA

C. Lartigue, S. Douthwaite, A. Lebaudy, 2014, Nucleic acids research.

Activity of the Ketolide Telithromycin Is Refractory to Erm Monomethylation of Bacterial rRNA

S. Douthwaite, Mingfu Liu, 2002, Antimicrobial Agents and Chemotherapy.

Stephen Douthwaite Substitutions in 23 S rRNA Macrolide Resistance Conferred by Base

S. Douthwaite, B. Vester, 2000 .

Design of camp–CRP‐activated promoters in Escherichia coli

S. Douthwaite, P. Valentin-Hansen, J. Martinussen, 1991, Molecular microbiology.

The activity of rRNA resistance methyltransferases assessed by MALDI mass spectrometry.

S. Douthwaite, F. Kirpekar, Rikke Lind Jensen, 2008, Methods in molecular medicine.

Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase.

S. Douthwaite, Mingfu Liu, G. W. Novotny, 2004, RNA.

Intrinsic resistance to aminoglycosides in Enterococcus faecium is conferred by the 16S rRNA m5C1404-specific methyltransferase EfmM.

S. Douthwaite, Y. Mechulam, E. Schmitt, 2011, RNA.

The aminoglycoside resistance methyltransferase Sgm impedes RsmF methylation at an adjacent rRNA nucleotide in the ribosomal A site.

S. Douthwaite, Fedora Babić, Sonja Čubrilo, 2009, RNA.

Studies on the Structure and Function of Ribosomal RNA

R. Gutell, H. Noller, C. Woese, 1986 .

Combinations of Macrolide Resistance Determinants in Field Isolates of Mannheimia haemolytica and Pasteurella multocida

S. Douthwaite, R. Warrass, Benoît Desmolaize, 2011, Antimicrobial Agents and Chemotherapy.

Biofilm Formation and Motility Are Promoted by Cj0588-Directed Methylation of rRNA in Campylobacter

S. Douthwaite, S. Rose, T. Uśpieński, 2018 .

Identifying the methyltransferases for m(5)U747 and m(5)U1939 in 23S rRNA using MALDI mass spectrometry.

S. Douthwaite, F. Kirpekar, C. T. Madsen, 2003, Nucleic acids research.

Mutations in Conserved Helix 69 of 23S rRNA of Thermus thermophilus That Affect Capreomycin Resistance but Not Posttranscriptional Modifications

S. Douthwaite, W. Chungjatupornchai, S. T. Gregory, 2008, Journal of bacteriology.

Molecular Mechanisms by Which rRNA Mutations Confer Resistance to Clindamycin

J. Poehlsgaard, S. Douthwaite, E. Böttger, 2005, Antimicrobial Agents and Chemotherapy.

Functional interactions within 23S rRNA involving the peptidyltransferase center

S. Douthwaite, 1992, Journal of bacteriology.

Increased NADPH concentration obtained by metabolic engineering of the pentose phosphate pathway in Aspergillus niger

J. Visser, S. Douthwaite, J. Nøhr, 2005, The FEBS journal.

Stephen Posttranscriptional Modifications Capreomycin Resistance but Not That Affect Thermus thermophilus rRNA of Mutations in Conserved Helix 69 of 23 S

S. Douthwaite, W. Chungjatupornchai, S. T. Gregory, 2008 .

A ribonuclease-resistant region of 5S RNA and its relation to the RNA binding sites of proteins L18 and L25.

R. Garrett, S. Douthwaite, R. Wagner, 1979, Nucleic acids research.

YbeA is the m3Psi methyltransferase RlmH that targets nucleotide 1915 in 23S rRNA.

Joanna M. Kasprzak, Katarzyna H. Kaminska, S. Douthwaite, 2008, RNA.

Higher-order structure in the 3'-terminal domain VI of the 23 S ribosomal RNAs from Escherichia coli and Bacillus stearothermophilus.

R. Garrett, S. Douthwaite, A. Christensen, 1984, Journal of molecular biology.

Improved RNA cleavage by LNAzyme derivatives of DNAzymes.

S. Douthwaite, J. Wengel, B. Vester, 2004, Biochemical Society transactions.

Isolation of temperature-sensitive mutants of 16 S rRNA in Escherichia coli.

H. Noller, S. Douthwaite, H. Mori, 1989, Journal of molecular biology.

Ketolide resistance in Streptococcus pyogenes correlates with the degree of rRNA dimethylation by Erm

S. Douthwaite, L. Jakobsen, J. Jalava, 2005, Molecular microbiology.

Mapping posttranscriptional modifications in 5S ribosomal RNA by MALDI mass spectrometry.

S. Douthwaite, P. Roepstorff, F. Kirpekar, 2000, RNA.

Antibiotic interactions at the GTPase‐associated centre within Escherichia coli 23S rRNA.

R. Garrett, S. Douthwaite, J. Egebjerg, 1989, The EMBO journal.

Macrolide antibiotic interaction and resistance on the bacterial ribosome.

J. Poehlsgaard, S. Douthwaite, 2003, Current opinion in investigational drugs.

Structure of 23S rRNA hairpin 35 and its interaction with the tylosin‐resistance methyltransferase RlmAII

Eric Guittet, S. Douthwaite, D. Fourmy, 2003, The EMBO journal.

YgdE is the 2′‐O‐ribose methyltransferase RlmM specific for nucleotide C2498 in bacterial 23S rRNA

S. Douthwaite, J. Bujnicki, M. O'Connor, 2009, Molecular microbiology.

Crystal structure of the Escherichia coli 23S rRNA:m5C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes.

Joanna M. Kasprzak, S. Douthwaite, J. Bujnicki, 2008, Journal of molecular biology.

Jacob II of 23 S rRNA Domainafter Disruption of Interactions with Ketolide Antimicrobial Activity Persists

J. Poehlsgaard, S. Douthwaite, L. Jakobsen, 2004 .

Helcococcus kunzii methyltransferase Erm(47) responsible for MLSB resistance is induced by diverse ribosome-targeting antibiotics.

S. Douthwaite, V. Cattoir, F. Guérin, 2019, The Journal of antimicrobial chemotherapy.

Mycobacterium smegmatis Erm(38) Is a Reluctant Dimethyltransferase

S. Douthwaite, L. Jakobsen, C. T. Madsen, 2005, Antimicrobial Agents and Chemotherapy.

Higher order structure in the 3'-minor domain of small subunit ribosomal RNAs from a gram negative bacterium, a gram positive bacterium and a eukaryote.

R. Garrett, S. Douthwaite, A. Christensen, 1983, Journal of molecular biology.

Transcription analysis of the Streptomyces coelicolor A3(2) rrnA operon.

M. Bibb, G. V. van Wezel, S. Douthwaite, 1994, Microbiology.

Mutations in domain II of 23 S rRNA facilitate translation of a 23 S rRNA-encoded pentapeptide conferring erythromycin resistance.

S. Douthwaite, A. Mankin, T. Tenson, 1996, Journal of molecular biology.

Effect of mutations in the A site of 16 S rRNA on aminoglycoside antibiotic-ribosome interaction.

J. Puglisi, K. Dahlquist, S. Douthwaite, 1999, Journal of molecular biology.

Secondary structure of prokaryotic 5S ribosomal ribonucleic acids: a study with ribonucleases.

R. Garrett, S. Douthwaite, 1981, Biochemistry.

Cooperative assembly of proteins in the ribosomal GTPase centre demonstrated by their interactions with mutant 23S rRNAs

G. Rosendahl, S. Douthwaite, S. Douthwaite, 1995, Nucleic Acids Res..

Interaction of the tylosin-resistance methyltransferase RlmA II at its rRNA target differs from the orthologue RlmA I.

S. Douthwaite, D. Fourmy, L. Jakobsen, 2008, Journal of molecular biology.

LNA and α-L-LNA: Towards Therapeutic Applications

S. Douthwaite, J. Wengel, B. Vester, 2003 .

LNA and alpha-L-LNA: towards therapeutic applications.

S. Douthwaite, J. Wengel, B. Vester, 2003, Nucleosides, nucleotides & nucleic acids.

Methyltransferase Erm(37) Slips on rRNA to Confer Atypical Resistance in Mycobacterium tuberculosis*

S. Douthwaite, L. Jakobsen, F. Doucet-Populaire, 2005, Journal of Biological Chemistry.

The tylosin-resistance methyltransferase RlmA(II) (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748.

J. Poehlsgaard, S. Douthwaite, Mingfu Liu, 2004, Journal of molecular biology.

A novel Erm monomethyltransferase in antibiotic‐resistant isolates of Mannheimia haemolytica and Pasteurella multocida

S. Douthwaite, R. Warrass, Benoît Desmolaize, 2011, Molecular microbiology.

Studies on the structure and function of 16S ribosomal RNA using structure-specific chemical probes

H. Noller, S. Douthwaite, D. Moazed, 1985, Journal of Biosciences.

Helcococcus kunzii MLS B resistance methyltransferase erm (47) is induced by 4 diverse ribosome-targeting antibiotics

S. Douthwaite, F. Guérin, S. Rose, 2019 .

Comparison of Escherichia coli tRNAPhe in the free state, in the ternary complex and in the ribosomal A and P sites by chemical probing.

R. Garrett, S. Douthwaite, R. Wagner, 1983, European journal of biochemistry.