M. Page

发表

Restriction site-free insertion of PCR products directionally into vectors.

G. Chen, N. Qiu, C. Karrer, 2000, BioTechniques.

Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from staphylococcus aureus

M. Page, A. D'arcy, M. Hennig, 1998, Nature Structural Biology.

Stemming the tide? Advances in antibiotic discovery and development in the face of emerging resistance and financial constraint.

M. Page, L. Kellenberger, Malcolm G P Page, 2012, Current opinion in pharmacology.

Structural and kinetic characterization of a β-lactamase-inhibitor protein

André Matagne, J. Frère, M. Page, 1994, Nature.

Biological Activities of Novel Gyrase Inhibitors of the Aminocoumarin Class

M. Page, A. Maxwell, C. Anderle, 2008, Antimicrobial Agents and Chemotherapy.

HYDROGEN BONDING AND PROTEIN PERTURBATION IN BETA -LACTAM ACYL-ENZYMES OF STREPTOCOCCUS PNEUMONIAE PENICILLIN-BINDING PROTEIN PBP2X

P. Caspers, M. Page, C. Wharton, 1999 .

Structure-Activity Relationships of Different β-Lactam Antibiotics against a Soluble Form of Enterococcus faecium PBP5, a Type II Bacterial Transpeptidase

P. Caspers, M. Page, L. Rice, 2005, Antimicrobial Agents and Chemotherapy.

What we may expect from novel antibacterial agents in the pipeline with respect to resistance and pharmacodynamic principles

M. Page, K. Bush, 2017, Journal of Pharmacokinetics and Pharmacodynamics.

Crystallization and preliminary X-ray characterization of maltoporin from Escherichia coli.

M. Page, R. Pauptit, T. Keller, 1990, Journal of molecular biology.

Membrane disrupting antimicrobial peptide dendrimers with multiple amino termini

J. Reymond, M. Page, D. Fotiadis, 2012 .

Bead diffusion assay for discovering antimicrobial cyclic peptides.

J. Reymond, M. Page, Noélie Maillard, 2011, Chemical communications.

Penicillin-binding proteins: evergreen drug targets.

J. Frère, M. Page, 2014, Current opinion in pharmacology.

The Pseudomonas aeruginosa PA14 ABC Transporter NppA1A2BCD Is Required for Uptake of Peptidyl Nucleoside Antibiotics

M. Page, K. Severinov, S. Dubiley, 2015, Journal of bacteriology.

Multiple conformations of the acylenzyme formed in the hydrolysis of methicillin by Citrobacter freundii beta-lactamase: a time-resolved FTIR spectroscopic study.

M. Page, C. Wharton, M. Kania, 1999, Biochemistry.

Structure and Function of the PiuA and PirA Siderophore-Drug Receptors from Pseudomonas aeruginosa and Acinetobacter baumannii

M. Page, J. Naismith, D. Rolo, 2017, Antimicrobial Agents and Chemotherapy.

The complex of ferric-enterobactin with its transporter from Pseudomonas aeruginosa suggests a two-site model

M. Page, J. Naismith, M. Ceccarelli, 2019, Nature Communications.

Crystallographic analysis of bacterial signal peptidase in ternary complex with arylomycin A2 and a beta-sultam inhibitor.

C. Luo, M. Page, M. Paetzel, 2009, Biochemistry.

Rapid identification of substrates for novel proteases using a combinatorial peptide library.

M. Page, V. Schauer-Vukašinović, D. Schlatter, 2000, Journal of combinatorial chemistry.

Complexes formed by the siderophore-monosulfactam conjugate BAL30072 and their interaction with the outer membrane receptor PiuA of P. aeruginosa

M. Page, Ilaria Serra, S. Milenkovic, 2018 .

In Vitro Properties of BAL30072, a Novel Siderophore Sulfactam with Activity against Multiresistant Gram-Negative Bacilli

M. Page, E. Desarbre, Clothilde Dantier, 2010, Antimicrobial Agents and Chemotherapy.

Beta-Lactam Antibiotics

M. Page, 2012 .

Structure and function of the PiuA and PirA siderophore-drug 2 receptors from 3 Pseudomonas aeruginosa and Acinetobacter baumannii

M. Page, J. Naismith, D. Rolo, 2016 .

Resistance Mediated by Penicillin-Binding Proteins

M. Page, 2007 .

Binding of Ceftobiprole and Comparators to the Penicillin-Binding Proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae

M. Page, K. Bush, M. Kania, 2007, Antimicrobial Agents and Chemotherapy.

Emerging cephalosporins

M. Page, 2007, Expert opinion on emerging drugs.

Cephalosporins in clinical development

M. Page, 2004, Expert opinion on investigational drugs.

Discovery and development of new antibacterial agents targeting Gram-negative bacteria in the era of pandrug resistance: is the future promising?

M. Page, K. Bush, 2014, Current opinion in pharmacology.

Involvement of Fe Uptake Systems and AmpC β-Lactamase in Susceptibility to the Siderophore Monosulfactam BAL30072 in Pseudomonas aeruginosa

M. Page, C. van Delden, T. Köhler, 2013, Antimicrobial Agents and Chemotherapy.

Activity of the Novel Macrolide BAL19403 against Ribosomes from Erythromycin-Resistant Propionibacterium acnes

M. Page, L. Kellenberger, J. Dreier, 2007, Antimicrobial Agents and Chemotherapy.

Interactions of ceftobiprole with beta-lactamases from molecular classes A to D.

M. Page, K. Bush, M. Kania, 2007, Antimicrobial agents and chemotherapy.

Ceftobiprole – a case study

M. Page, 2007, Expert opinion on drug discovery.

Drug Discovery Case History

M. Page, 2006 .

Use of resazurin to detect mefloquine as an efflux-pump inhibitor in Pseudomonas aeruginosa and Escherichia coli.

M. Page, J. Dreier, Faustino Vidal-Aroca, 2009, Journal of microbiological methods.

Impact of Specific pbp5 Mutations on Expression of β-Lactam Resistance in Enterococcus faecium

P. Caspers, M. Page, L. Rice, 2004, Antimicrobial Agents and Chemotherapy.

The kinetics of non-stoichiometric bursts of beta-lactam hydrolysis catalysed by class C beta-lactamases.

M. Page, Malcolm G. P. Page, 1993, Biochemical Journal.

The effects of pH on proton sugar symport activity of the lactose permease purified from Escherichia coli.

J. Rosenbusch, M. Page, I. Yamato, 1988, The Journal of biological chemistry.

The role of protons in the mechanism of galactoside transport via the lactose permease of Escherichia coli.

M. Page, 1987, Biochimica et biophysica acta.

In vitro activity of the siderophore monosulfactam BAL30072 against meropenem-non-susceptible Acinetobacter baumannii.

M. Page, P. Higgins, M. Hackel, 2012, The Journal of antimicrobial chemotherapy.

In vivo and in vitro activity of the siderophore monosulfactam BAL30072 against Acinetobacter baumannii.

M. Page, R. Bonomo, K. Hujer, 2011, The Journal of antimicrobial chemotherapy.

In Vitro and In Vivo Properties of BAL30376, a β-Lactam and Dual β-Lactamase Inhibitor Combination with Enhanced Activity against Gram-Negative Bacilli That Express Multiple β-Lactamases

M. Page, K. Gebhardt, A. Schmitt-Hoffmann, 2011, Antimicrobial Agents and Chemotherapy.

In Vitro and In Vivo Properties of Ro 63-9141, a Novel Broad-Spectrum Cephalosporin with Activity against Methicillin-Resistant Staphylococci

M. Page, R. Then, P. Angehrn, 2001, Antimicrobial Agents and Chemotherapy.

β-Lactamase inhibitors

M. Page, 2000 .

Role of asparagine 152 in catalysis of beta-lactam hydrolysis by Escherichia coli AmpC beta-lactamase studied by site-directed mutagenesis.

A. Dubus, M. Page, S. Normark, 1995, Biochemistry.

Hydrogen bonding and protein perturbation in beta-lactam acyl-enzymes of Streptococcus pneumoniae penicillin-binding protein PBP2x.

P. Caspers, M. Page, C. Wharton, 1999, The Biochemical journal.

Structure and function of the dihydropteroate synthase from Staphylococcus aureus.

M. Page, A. D'arcy, I. Hampele, 1997, Journal of molecular biology.

A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance.

M. Page, A. D'arcy, C. Oefner, 1997, Journal of molecular biology.

Characterization of the gene for the chromosomal dihydrofolate reductase (DHFR) of Staphylococcus epidermidis ATCC 14990: the origin of the trimethoprim-resistant S1 DHFR from Staphylococcus aureus?

M. Page, G. Dale, C. Broger, 1995, Journal of bacteriology.

Cautious Optimism for the Antibacterial Pipeline: Despite dire warnings, there is resurgent effort to develop novel antibiotics, with several dozen candidate drugs already entered into clinical trials

M. Page, K. Bush, M. Pucci, 2014 .

Antimicrobial and DNA Gyrase-Inhibitory Activities of Novel Clorobiocin Derivatives Produced by Mutasynthesis

M. Page, L. Heide, Shu‐Ming Li, 2004, Antimicrobial Agents and Chemotherapy.

Universal restriction site-free cloning method using chimeric primers.

Guo Jun Chen, N. Qiu, M. Page, 2002, BioTechniques.

Design, Synthesis, and Evaluation of 2β-Alkenyl Penam Sulfone Acids as Inhibitors of β-Lactamases†

M. Page, F. Winkler, M. Kania, 1996 .

Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents.

M. Page, D. Banner, G. Rosse, 2000, Journal of medicinal chemistry.

Structure-based design of beta-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams.

M. Page, F. Winkler, C. Oefner, 1998, Journal of medicinal chemistry.

Structure-based design of beta-lactamase inhibitors. 2. Synthesis and evaluation of bridged sulfactams and oxamazins.

M. Page, K. Gubernator, C. Hubschwerlen, 1998, Journal of medicinal chemistry.

Propenylamide and propenylsulfonamide cephalosporins as a novel class of anti-MRSA beta-lactams.

A. I. Glushkov, P. Caspers, M. Page, 2010, Bioorganic & medicinal chemistry letters.

Structural Investigations of the Inhibition of Escherichia coli AmpC β-Lactamase by Diazabicyclooctanes

M. Page, C. Schofield, T. Leissing, 2020, Antimicrobial Agents and Chemotherapy.

The role of the outer membrane of Gram-negative bacteria in antibiotic resistance: Ajax' shield or Achilles' heel?

M. Page, 2012, Handbook of experimental pharmacology.

Complexes formed by the siderophore-based monosulfactam antibiotic BAL30072 and their interaction with the outer membrane receptor PiuA of P. aeruginosa

M. Page, J. Naismith, M. Ceccarelli, 2019, BioMetals.

In vitro activity of isavuconazole against 140 reference fungal strains and 165 clinically isolated yeasts from Japan.

M. Page, M. Arisawa, Kazuko Kobayashi, 2010, International journal of antimicrobial agents.

Combined effects of the siderophore monosulfactam BAL30072 and carbapenems on multidrug-resistant Gram-negative bacilli.

M. Page, K. Gebhardt, A. Schmitt-Hoffmann, 2013, The Journal of antimicrobial chemotherapy.

Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering

Brad Spellberg, Robert A. Bonomo, M. Page, 2017, mBio.

Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Stuart P. McElroy, Philip S. Jones, M. Page, 2021, Nature Chemistry.

Enhancing resistance to cephalosporins in class C beta-lactamases: impact of Gly214Glu in CMY-2.

M. Page, R. Bonomo, D. Paterson, 2010, Biochemistry.

Anti-MRSA β-lactams in development

M. Page, 2006 .

Anti-MRSA beta-lactams in development.

M. Page, 2006, Current opinion in pharmacology.

Prospects for the next anti-Pseudomonas drug.

M. Page, J. Heim, 2009, Current opinion in pharmacology.

The kinetics of non-stoichiometric bursts of-lactam hydrolysis catalysed by class C f-lactamases

M. Page, Pharma, 2005 .

b-Lactamase inhibitors.

Malcolm G. P. Page, M. Page, 2000, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

The detection and characterization of an induced RNA polymerase in the chorioallantoic membranes of embryonated eggs infected with influenza A2 virus.

M. Page, K. Brammer, J. D. Coombes, 1969, Virology.

Characterisation in vivo of the reactive thiol groups of the lactose permease from Escherichia coli and a mutant; exposure, reactivity and the effects of substrate binding.

M. Page, I. West, Malcolm G. P. Page, 1986, Biochimica et biophysica acta.

Discovering New Classes of Brugia malayi Asparaginyl-tRNA Synthetase Inhibitors and Relating Specificity to Conformational Change

Sai Chetan K. Sukuru, Leslie A. Kuhn, Jonathan B. Hill, 2006, J. Comput. Aided Mol. Des..

Interactions of Ceftobiprole with β-Lactamases from Molecular Classes A to D

M. Page, K. Bush, M. Kania, 2007, Antimicrobial Agents and Chemotherapy.

The incorporation of cytidine 5'-monophosphate and other ribonucleotides by an enzyme preparation from rat-liver microsomes.

M. Page, H. Klemperer, G. R. Haynes, 1967, The Biochemical journal.

Genetic Analysis and Functional Characterization of the Streptococcus pneumoniae vic Operon

M. Page, C. Thompson, R. Lange, 2002, Infection and Immunity.

The kinetics of the beta-galactoside-proton symport of Escherichia coli.

M. Page, I. West, 1981, The Biochemical journal.

Cloning, over-expression and the catalytic properties of the EcoP15 modification methylase from Escherichia coli.

M. Page, T. Bickle, D. Rao, 1989, Journal of molecular biology.

Peptide Deformylase as an Antibacterial Drug Target: Target Validation and Resistance Development

M. Page, H. Locher, B. Takács, 2001, Antimicrobial Agents and Chemotherapy.

High-Throughput Screening of Dipeptide Utilization Mediated by the ABC Transporter DppBCDF and Its Substrate-Binding Proteins DppA1-A5 in Pseudomonas aeruginosa

M. Page, T. Köhler, D. Pletzer, 2014, PloS one.

Peptide Deformylase as an Antibacterial Drug Target: Assays for Detection of Its Inhibition in Escherichia coli Cell Homogenates and Intact Cells

M. Page, S. Evers, C. Apfel, 2001, Antimicrobial Agents and Chemotherapy.

Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli

C. Fishwick, M. Page, C. Schofield, 2020, Biomolecules.

Structural Insights into the Anti-methicillin-resistant Staphylococcus aureus (MRSA) Activity of Ceftobiprole*

M. Page, N. Strynadka, M. Gretes, 2012, The Journal of Biological Chemistry.

Development of a Sensitive and Specific Enzyme-Linked Immunosorbent Assay for Detecting and Quantifying CMY-2 and SHV β-Lactamases

M. Page, R. Bonomo, A. Hujer, 2002, Journal of Clinical Microbiology.

Getting Drugs into Gram-Negative Bacteria: Rational Rules for Permeation through General Porins.

M. Page, J. Naismith, M. Winterhalter, 2018, ACS infectious diseases.

Preacinetobactin not acinetobactin is essential for iron uptake by the BauA transporter of the pathogen Acinetobacter baumannii

M. Page, J. Naismith, M. Ceccarelli, 2018, eLife.

When is the outer membrane of Escherichia coli rate-limiting for uptake of galactosides?

M. Page, I. West, I C West, 1984, Journal of theoretical biology.

A kinetic analysis of the inhibition of FOX-4 β-lactamase, a plasmid-mediated AmpC cephalosporinase, by monocyclic β-lactams and carbapenems.

M. Page, R. Bonomo, A. Hujer, 2014, The Journal of antimicrobial chemotherapy.

A dynamic structure for the acyl-enzyme species of the antibiotic aztreonam with the Citrobacter freundii beta-lactamase revealed by infrared spectroscopy and molecular dynamics simulations.

M. Page, C. Wharton, P. K. Bryant, 2003, Biochemistry.

Extended-spectrum β-lactamases : structure and kinetic mechanism

M. Page, 2008 .

A Unified Numbering Scheme for Class C β-Lactamases

M. Page, 2019, Antimicrobial Agents and Chemotherapy.

The role of tyrosine 150 in catalysis of beta-lactam hydrolysis by AmpC beta-lactamase from Escherichia coli investigated by site-directed mutagenesis.

A. Dubus, M. Page, S. Normark, 1994, Biochemistry.

Global Transcriptome Analysis of the Responses of a Fluoroquinolone-Resistant Streptococcus pneumoniae Mutant and Its Parent to Ciprofloxacin

M. Page, L. Piddock, E. Marrer, 2006, Antimicrobial Agents and Chemotherapy.

New molecules from old classes: revisiting the development of beta-lactams.

M. Page, J. Heim, 2009, IDrugs : the investigational drugs journal.

Structure‐Based Design of β‐Lactamase Inhibitors. Part 2. Synthesis and Evaluation of Bridged Sulfactams and Oxamazins.

M. Page, K. Gubernator, C. Hubschwerlen, 1999 .

Cloning and characterization of a novel, plasmid-encoded trimethoprim-resistant dihydrofolate reductase from Staphylococcus haemolyticus MUR313

M. Page, G. Dale, H. Langen, 1995, Antimicrobial agents and chemotherapy.

haemolyticus MUR 313 . dihydrofolate reductase from Staphylococcus plasmid-encoded trimethoprim-resistant Cloning and characterization of a novel

M. Page, G. Dale, H. Langen, 1995 .

Molecular Basis of Filtering Carbapenems by Porins from β-Lactam-resistant Clinical Strains of Escherichia coli*

M. Page, J. Naismith, M. Winterhalter, 2015, The Journal of Biological Chemistry.

Synthesis and characterization of the arylomycin lipoglycopeptide antibiotics and the crystallographic analysis of their complex with signal peptidase.

C. Luo, M. Page, M. Paetzel, 2011, Journal of the American Chemical Society.

Antibacterial properties of Ro 40-6890, a broad-spectrum cephalosporin, and its novel orally absorbable ester, Ro 41-3399

M. Page, C. Hubschwerlen, R. Then, 1992, Antimicrobial Agents and Chemotherapy.

Antibacterial Properties ofRo40-6890, aBroad-Spectrum Cephalosporin, andItsNovelOrally Absorbable Ester, Ro41-3399 PETERANGEHRN,*PETERHOHL,CHRISTIANHUBSCHWERLEN,

M. Page, R. Then, 1992 .

Class D β-Lactamases

M. Page, D. Livermore, F. Danel, 2007 .

Effect of divalent metal cations on the dimerization of OXA-10 and -14 class D beta-lactamases from Pseudomonas aeruginosa.

M. Page, M. Paetzel, N. Strynadka, 2001, Biochemistry.

Crystal structure of the class D β-lactamase OXA-10

M. Page, M. Paetzel, N. Strynadka, 2000, Nature Structural Biology.

Direct influence of S9 liver homogenate on fluorescence signals: impact on practical applications in a bacterial genotoxicity assay.

M. Page, C. Apfel, E. Gocke, 2002, Mutation research.

Crystallographic and Biophysical Analysis of a Bacterial Signal Peptidase in Complex with a Lipopeptide-based Inhibitor*

M. Page, M. Paetzel, R. Dalbey, 2004, Journal of Biological Chemistry.

Involvement of the Putative ATP-Dependent Efflux Proteins PatA and PatB in Fluoroquinolone Resistance of a Multidrug-Resistant Mutant of Streptococcus pneumoniae

M. Page, K. Schad, L. Piddock, 2006, Antimicrobial Agents and Chemotherapy.

Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci.

M. Page, C. Hubschwerlen, H. Stalder, 1996, Journal of medicinal chemistry.

In vitro activity of BAL30072 against Burkholderia pseudomallei.

M. Page, H. Schweizer, Brian H. Kvitko, 2011, International journal of antimicrobial agents.

Topography of lactose permease from Escherichia coli.

J. Rosenbusch, M. Page, 1988, The Journal of biological chemistry.

Structure‐Based Design of Potent Beta‐Lactamase Inhibitors

M. Page, F. Winkler, C. Oefner, 2008 .

Essential role of histidine 20 in the catalytic mechanism of Escherichia coli peptidyl-tRNA hydrolase.

Guo Jun Chen, M. Page, J. J. Goodall, 2004, Biochemistry.

Asparaginyl-tRNA synthetase pre-transfer editing assay.

P. Caspers, M. Page, M. Härtlein, 2011, Current drug discovery technologies.

The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae.

C. Gray, M. Page, A. D'arcy, 1999, Journal of molecular biology.

Kinetics of lactose transport into Escherichia coli in the presence and absence of a protonmotive force

M. Page, I. West, 1980, FEBS letters.

Alternative-substrate inhibition and the kinetic mechanism of the beta-galactoside/proton symport of Escherichia coli.

M. Page, Y. Jou, 1982, The Biochemical journal.

Plasmid-mediated colistin resistance in a patient infected with Klebsiella pneumoniae.

M. Page, T. Schwede, S. Nicolet, 2016, Lancet. Infectious Diseases (Print).