F. Tortella

发表

Quantitative electroencephalography spectral analysis and topographic mapping in a rat model of middle cerebral artery occlusion

X. C. Lu, A. Williams, F. Tortella, 2001, Neuropathology and applied neurobiology.

A novel multicenter preclinical drug screening and biomarker consortium for experimental traumatic brain injury: operation brain trauma therapy.

P. Kochanek, F. Tortella, H. Bramlett, 2011, The Journal of trauma.

Systems biology approaches for discovering biomarkers for traumatic brain injury.

Jaques Reifman, Chenggang Yu, Bhaskar Dutta, 2013, Journal of neurotrauma.

Common data elements for traumatic brain injury: recommendations from the biospecimens and biomarkers working group.

G. Manley, T. Veenstra, G. Ling, 2010, Archives of physical medicine and rehabilitation.

Delayed Secondary Phase of Peri-Infarct Depolarizations after Focal Cerebral Ischemia: Relation to Infarct Growth and Neuroprotection

F. Tortella, J. Hartings, M. Rolli, 2003, The Journal of Neuroscience.

AC Electrocorticographic Correlates of Peri-Infarct Depolarizations during Transient Focal Ischemia and Reperfusion

F. Tortella, J. Hartings, M. Rolli, 2006, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Acute and delayed neuroinflammatory response following experimental penetrating ballistic brain injury in the rat

F. Tortella, J. Dave, Anthony J. Williams, 2007, Journal of Neuroinflammation.

Minor and repetitive head injury.

F. Tortella, R. Hayes, A. Buki, 2015, Advances and technical standards in neurosurgery.

The effect of voluntary exercise exposure on histological and neurobehavioral outcomes after ischemic brain injury in the rat

Richard Bauman, F. Tortella, R. Bauman, 2003, Physiology & Behavior.

Neurotoxicity of artemisinin analogs in vitro

F. Tortella, D. Wesche, M. DeCoster, 1994, Antimicrobial Agents and Chemotherapy.

Proteomic identification of biomarkers of traumatic brain injury

Ming Cheng Liu, Stephen B. Lewis, F. Tortella, 2005, Expert review of proteomics.

Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia

F. Tortella, A. Faden, A. Williams, 2001, Brain Research.

Combination therapy of levetiracetam and gabapentin against nonconvulsive seizures induced by penetrating traumatic brain injury

F. Tortella, X. Lu, Z. Liao, 2017, The journal of trauma and acute care surgery.

Nicotinamide Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

P. Kochanek, F. Tortella, H. Bramlett, 2016, Journal of neurotrauma.

Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

P. Kochanek, F. Tortella, H. Bramlett, 2016, Journal of neurotrauma.

Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

P. Kochanek, F. Tortella, H. Bramlett, 2016, Journal of neurotrauma.

Protein Biomarkers in Traumatic Brain Injury: An Omics Approach

F. Tortella, J. Dave, Kevin K. W. Wang, 2014 .

The Diagnosis of Traumatic Brain Injury on the Battlefield

F. Tortella, Kara E. Schmid, 2012, Front. Neur..

Comparing calpain- and caspase-3-mediated degradation patterns in traumatic brain injury by differential proteome analysis.

F. Tortella, R. Hayes, J. Dave, 2006, The Biochemical journal.

Brain oxygen tension monitoring following penetrating ballistic-like brain injury in rats

F. Tortella, X. Lu, D. Shear, 2012, Journal of Neuroscience Methods.

Delayed Treatment of Ischemia/Reperfusion Brain Injury: Extended Therapeutic Window with the Proteosome Inhibitor MLN519

P. J. Elliot, F. Tortella, J. Dave, 2004, Stroke.

Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury

F. Tortella, R. Traystman, M. Yudkoff, 1999, Nature Medicine.

Ethosuximide and phenytoin dose-dependently attenuate acute nonconvulsive seizures after traumatic brain injury in rats.

F. Tortella, X. Lu, D. Shear, 2013, Journal of neurotrauma.

Differential pattern of expression of voltage-gated sodium channel genes following ischemic brain injury in rats

F. Tortella, J. Dave, J. Hunter, 2002, Neurotoxicity Research.

Down-regulation of sodium channel Nav1.1 expression by veratridine and its reversal by a novel sodium channel blocker, RS100642, in primary neuronal cultures

F. Tortella, J. Moffett, J. Dave, 2009, Neurotoxicity Research.

σ receptor-mediated neuroprotection against glutamate toxicity in primary rat neuronal cultures

F. Tortella, K. Klette, M. DeCoster, 1995, Brain Research.

Proteomic analysis and brain‐specific systems biology in a rodent model of penetrating ballistic‐like brain injury

F. Tortella, J. Dave, Kevin K. W. Wang, 2012, Electrophoresis.

Longitudinal assessment of gait abnormalities following penetrating ballistic-like brain injury in rats

F. Tortella, D. Shear, A. Mountney, 2013, Journal of Neuroscience Methods.

Erythropoietin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

P. Kochanek, F. Tortella, H. Bramlett, 2016, Journal of neurotrauma.

Temporal alterations in aquaporin and transcription factor HIF1α expression following penetrating ballistic-like brain injury (PBBI)

F. Tortella, J. Dave, Kara E. Schmid, 2014, Molecular and Cellular Neuroscience.

Long-term administration of amnion-derived cellular cytokine suspension promotes functional recovery in a model of penetrating ballistic-like brain injury

F. Tortella, J. Dave, Z. Liao, 2012, The journal of trauma and acute care surgery.

Challenging the Paradigms of Experimental TBI Models: From Preclinical to Clinical Practice.

F. Tortella, 2016, Methods in molecular biology.

P43/pro-EMAPII: a potential biomarker for discriminating traumatic versus ischemic brain injury.

F. Tortella, R. Hayes, J. Dave, 2009, Journal of Neurotrauma.

Neuroprotection with the proteasome inhibitor MLN519 in focal ischemic brain injury: Relation to nuclear factor κB (NF-κB), inflammatory gene expression, and leukocyte infiltration

F. Tortella, J. Dave, A. Williams, 2006, Neurochemistry International.

Ubiquitin C‐terminal hydrolase‐L1 as a biomarker for ischemic and traumatic brain injury in rats

F. Tortella, R. Hayes, J. Dave, 2010, The European journal of neuroscience.

Biokinetic analysis of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in severe traumatic brain injury patient biofluids.

A. Gabrielli, F. Tortella, C. Robertson, 2011, Journal of neurotrauma.

NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats

F. Tortella, J. Dave, X. Lu, 2009, Journal of Neuroinflammation.

Levetiracetam Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

P. Kochanek, F. Tortella, H. Bramlett, 2016, Journal of neurotrauma.

Repetitive cortical spreading depolarizations in a case of severe brain trauma

F. Tortella, J. Hartings, A. Strong, 2008, Neurological research.

d-ala2-methionine-enkephalinamide self-administration in the morphine-dependent rat

F. Tortella, J. Edward Moreton, 2004, Psychopharmacology.

Proteasome Inhibitor PS 519 Reduces Infarction and Attenuates Leukocyte Infiltration in a Rat Model of Focal Cerebral Ischemia

F. Tortella, P. Elliott, J. Adams, 2000 .

Neuroprotection from glutamate toxicity with ultra-low dose glutamate

F. Tortella, W. Jonas, Y. Lin, 2001, Neuroreport.

Synergism of human amnion-derived multipotent progenitor (AMP) cells and a collagen scaffold in promoting brain wound recovery: Pre-clinical studies in an experimental model of penetrating ballistic-like brain injury

F. Tortella, J. Dave, X. Lu, 2011, Brain Research.

Selective NR2B NMDA receptor antagonists are protective against staurosporine-induced apoptosis.

F. Tortella, J. Dave, A. Williams, 2002, European journal of pharmacology.

Electrocortical pathology in a rat model of penetrating ballistic-like brain injury.

F. Tortella, J. Hartings, Y. Si, 2011, Journal of neurotrauma.

Dextromethorphan attenuates post-ischemic hypoperfusion following incomplete global ischemia in the anesthetized rat

F. Tortella, T. Blackburn, N. J. Russell, 1989, Brain Research.

Intracranial pressure following penetrating ballistic-like brain injury in rats.

F. Tortella, X. Lu, Guo Wei, 2010, Journal of neurotrauma.

Detection of protein biomarkers using high-throughput immunoblotting following focal ischemic or penetrating ballistic-like brain injuries in rats

F. Tortella, R. Hayes, J. Dave, 2008, Brain injury.

Traumatic Brain Injury and Polytrauma in Theaters of Combat: The Case for Neurotrauma Resuscitation?

F. Tortella, L. Leung, 2015, Shock.

Effects of chronic treatment with two selective 5-HT2 antagonists on sleep in the rat

F. Tortella, T. Blackburn, R. Pastel, 1993, Pharmacology Biochemistry and Behavior.

Dextromethorphan and carbetapentane: centrally acting non-opioid antitussive agents with novel anticonvulsant properties

F. Tortella, J. Musacchio, 1986, Brain Research.

Neurochemical changes following combined hypoxemia and hemorrhagic shock in a rat model of penetrating ballistic-like brain injury: A microdialysis study

F. Tortella, D. Shear, Ying Deng-Bryant, 2016, The journal of trauma and acute care surgery.

Studies on opioid peptides as endogenous anticonvulsants.

F. Tortella, A. Cowan, 1982, Life sciences.

Anticonvulsant efficacy of N-methyl-D-aspartate antagonists against convulsions induced by cocaine.

F. Tortella, J. Witkin, B. Heifets, 1999, The Journal of pharmacology and experimental therapeutics.

Treatment with amnion-derived cellular cytokine solution (ACCS) induces persistent motor improvement and ameliorates neuroinflammation in a rat model of penetrating ballistic-like brain injury.

F. Tortella, D. Shear, Ryan D Readnower, 2015, Restorative neurology and neuroscience.

Correlations between blood-brain barrier disruption and neuroinflammation in an experimental model of penetrating ballistic-like brain injury.

F. Tortella, J. Dave, X. Lu, 2014, Journal of neurotrauma.

Neuroprotection and anti-seizure effects of levetiracetam in a rat model of penetrating ballistic-like brain injury.

F. Tortella, Krista L. Caudle, X. Lu, 2016, Restorative neurology and neuroscience.

Neuroprotection (focal ischemia) and neurotoxicity (electroencephalographic) studies in rats with AHN649, a 3-amino analog of dextromethorphan and low-affinity N-methyl-D-aspartate antagonist.

X. C. Lu, F. Tortella, A. Newman, 1999, The Journal of pharmacology and experimental therapeutics.

Dextromethorphan protects against cerebral injury following transient, but not permanent, focal ischemia in rats.

X. C. Lu, F. Tortella, P. Britton, 1997, Life sciences.

Caramiphen: a non-opioid antitussive with potent anticonvulsant properties in rats.

F. Tortella, J. Witkin, J. Musacchio, 1988, European journal of pharmacology.

The sodium channel blocker RS100642 reverses down-regulation of the sodium channel α-subunit Nav 1.1 expression caused by transient ischemic brain injury in rats

F. Tortella, J. Dave, A. Williams, 2009, Neurotoxicity Research.

A Military-Centered Approach to Neuroprotection for Traumatic Brain Injury

F. Tortella, D. Shear, 2013, Front. Neurol..

An autoradiographic study of dextromethorphan high‐affinity binding sites in rat brain: sodium‐dependency and colocalization with paroxetine

F. Tortella, N. Bowery, P. Meoni, 1997, British journal of pharmacology.

Comprehensive Evaluation of Neuroprotection Achieved by Extended Selective Brain Cooling Therapy in a Rat Model of Penetrating Ballistic-Like Brain Injury.

F. Tortella, X. Lu, D. Shear, 2016, Therapeutic hypothermia and temperature management.

Extraluminal cooling of bilateral common carotid arteries as a method to achieve selective brain cooling for neuroprotection.

F. Tortella, J. Hartings, X. Lu, 2008, Journal of neurotrauma.

Advanced and High-Throughput Method for Mitochondrial Bioenergetics Evaluation in Neurotrauma.

F. Tortella, P. Sullivan, D. Shear, 2016, Methods in molecular biology.

Approach to Modeling, Therapy Evaluation, Drug Selection, and Biomarker Assessments for a Multicenter Pre-Clinical Drug Screening Consortium for Acute Therapies in Severe Traumatic Brain Injury: Operation Brain Trauma Therapy.

P. Kochanek, F. Tortella, H. Bramlett, 2016, Journal of neurotrauma.

Operation Brain Trauma Therapy: Simvastatin Treatment in Traumatic Brain Injury

P. Kochanek, F. Tortella, H. Bramlett, 2016 .

Acute and subacute microRNA dysregulation is associated with cytokine responses in the rodent model of penetrating ballistic-like brain injury

F. Tortella, J. Dave, Kara E. Schmid, 2017, The journal of trauma and acute care surgery.

Subacute Changes in Cleavage Processing of Amyloid Precursor Protein and Tau following Penetrating Traumatic Brain Injury

F. Tortella, Kara E. Schmid, D. Shear, 2016, PLoS ONE.

Evaluation of transient forebrain ischemia induced by four vessel occlusion using schedule-controlled behavior

F. Tortella, J. Petras, R. Genovese, 1992, Physiology & Behavior.

Changes in Apoptotic Mechanisms Following Penetrating Ballistic-Like Brain Injury

F. Tortella, J. Dave, Kara E. Schmid, 2011, Journal of Molecular Neuroscience.

Studies on Neuronal Apoptosis Following Soman Exposure in the Rat

F. Tortella, J. Moffett, J. Dave, 2005 .

Opioid Peptides: Possible Physiological Role as Endogenous Anticonvulsants

F. Tortella, 1988 .

Methods of Drug Delivery in Neurotrauma.

F. Tortella, D. Shear, Ryan D Readnower, 2016, Methods in molecular biology.

AHN649: Preclinical Evaluation of a Novel Anticonvulsant and Neuroprotective Analog of Dextromethorphan

F. Tortella, A. Newman, P. Britton, 1997 .

Calcium dynamics in neurons treated with toxic and non-toxic concentrations of glutamate.

F. Tortella, J. Hunter, M. DeCoster, 1992, Neuroreport.

Dodecylglycerol provides partial protection against glutamate toxicity in neuronal cultures derived from different regions of embryonic rat brain.

F. Tortella, J. Dave, B. P. Doctor, 1997, Molecular and chemical neuropathology.

Role of calcium in sigma-mediated neuroprotection in rat primary cortical neurons

F. Tortella, K. Klette, M. DeCoster, 1995, Brain Research.

Dextromethorphan analogs are neuroprotective in vitro and block glutamate-induced excitotoxic calcium signals in neurons

F. Tortella, K. Klette, M. DeCoster, 1995, Neuroscience Letters.

Nefiracetam attenuates post-ischemic nonconvulsive seizures in rats and protects neuronal cell death induced by veratridine and glutamate.

F. Tortella, J. Dave, X. Lu, 2013, Life sciences.

Attenuation of the stimulant and convulsant effects of cocaine by 17-substituted-3-hydroxy and 3-alkoxy derivatives of dextromethorphan

F. Tortella, A. Zapata, A. Newman, 2003, Pharmacology Biochemistry and Behavior.

Experimental Models Combining TBI, Hemorrhagic Shock, and Hypoxemia.

F. Tortella, D. Shear, Ying Deng-Bryant, 2016, Methods in molecular biology.

The acute effects of hemorrhagic shock on cerebral blood flow, brain tissue oxygen tension, and spreading depolarization following penetrating ballistic-like brain injury.

F. Tortella, D. Shear, Guo Wei, 2013, Journal of neurotrauma.

Selective brain cooling in rats ameliorates intracerebral hemorrhage and edema caused by penetrating brain injury: possible involvement of heme oxygenase-1 expression.

F. Tortella, J. Dave, X. Lu, 2011, Journal of neurotrauma.

Intravenous Administration of Simvastatin Improves Cognitive Outcome following Severe Traumatic Brain Injury in Rats.

F. Tortella, X. Lu, D. Shear, 2016, Journal of neurotrauma.

Endogenous opioids and their receptors. Evidence for involvement in the postictal effects of electroconvulsive shock.

J. Holaday, F. Tortella, G. Belenky, 1986, Annals of the New York Academy of Sciences.

Treatment with the snail peptide CGX-1007 reduces DNA damage and alters gene expression of c-fos and bcl-2 following focal ischemic brain injury in rats

F. Tortella, J. Moffett, J. Dave, 2003, Experimental Brain Research.

Phospholipase A2-induced neurotoxicity in vitro and in vivo in rats

F. Tortella, R. Smallridge, J. Dave, 1995, Brain Research.

Severity level and injury track determine outcome following a penetrating ballistic-like brain injury in the rat

G. Ling, F. Tortella, A. Williams, 2006, Neuroscience Letters.

Pituitary opioid involvement in ECS-postictal electrogenesis and behavioral depression in rats

J. Holaday, F. Tortella, A. Cowan, 1984, Peptides.

Morphine tolerance increases -noncompetative d binding sites?

J. Holaday, F. Tortella, T. Burke, 1986 .

Electroconvulsive Shock Activates Endogenous Opioid Systems: Behavioral and Biochemical Correlates

J. Holaday, F. Tortella, G. Belenky, 1986, Annals of the New York Academy of Sciences.

Comparison of the anticonvulsant effects of opioid peptides and etorphine in rats after icv administration.

F. Tortella, M. Adler, A. Cowan, 1981, Life Science.

Anticonvulsant activity of caramiphen analogs.

F. Tortella, J. Stubbins, D. DeHaven-Hudkins, 1995, Life sciences.

Penetrating ballistic-like brain injury in the rat: differential time courses of hemorrhage, cell death, inflammation, and remote degeneration.

F. Tortella, J. Hartings, M. Rolli, 2006, Journal of neurotrauma.

Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury

A. Gabrielli, F. Tortella, P. Bossù, 2012, Brain injury.

Synthesis of Findings, Current Investigations, and Future Directions: Operation Brain Trauma Therapy.

P. Kochanek, F. Tortella, H. Bramlett, 2016, Journal of neurotrauma.

Anticonvulsant effects of dextrorphan in rats: possible involvement in dextromethorphan-induced seizure protection.

M. Pontecorvo, F. Tortella, J. Ferkany, 1988, Life sciences.

EEG, EMG and behavioral evidence for the involvement of endorphin systems in postictal events after electroconvulsive shock in rats.

F. Tortella, A. Cowan, 1982, Life sciences.

Opiate-like electroencephalographic and behavioral effects of electroconvulsive shock in rats.

J. Holaday, F. Tortella, G. Belenky, 1981, European journal of pharmacology.

Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions

Michael J. Leggieri, R. Depalma, F. Tortella, 2017, Brain injury.

Pre-Clinical Traumatic Brain Injury Common Data Elements: Toward a Common Language Across Laboratories.

D. A. Bergstrom, F. Tortella, S. Ahlers, 2015, Journal of neurotrauma.

Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention.

F. Tortella, C. Robertson, R. Hayes, 2012, Annals of emergency medicine.

Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention

F. Tortella, C. Robertson, R. Hayes, 2012, The journal of trauma and acute care surgery.

Opioids and Stress: Effects Upon Nociception, Behavior, and Autonomic Function Following Electroconvulsive Shock, Circulatory Shock, or Central Nervous System Injury

J. Holaday, F. Tortella, J. Long, 1989 .

Characterization of opioid peptide-like anticonvulsant activity in rat cerebrospinal fluid

F. Tortella, J. Long, 1988, Brain Research.

Effects of adrenalectomy and hypophysectomy on postictal seizure protection

F. Tortella, J. Long, 1987, Brain Research.

Endogenous anticonvulsant substance in rat cerebrospinal fluid after a generalized seizure.

F. Tortella, J. Long, 1985, Science.

Endogenous opioid systems: Physiological role in the self-limitation of seizures

J. Holaday, F. Tortella, J. Long, 1985, Brain Research.

Studies on the excitatory and inhibitory influence of intracerebroventricularly injected opioids on seizure thresholds in rats

F. Tortella, M. Adler, A. Cowan, 1984, Neuropharmacology.

Repeated electroconvulsive shock or chronic morphine treatment increases the number of 3H-D-Ala2,D-Leu5-enkephalin binding sites in rat brain membranes.

J. Holaday, F. Tortella, G. Belenky, 1982, Life sciences.

Electroencephalographic and behavioral tolerance to and cross-tolerance between D-Ala2-methionine-enkephalinamide and morphine in the rat.

F. Tortella, J. Moreton, N. Khazan, 1979, The Journal of pharmacology and experimental therapeutics.

Electroencephalographic and behavioral effects of D-ala2-methionine-enkephalinamide and morphine in the rat.

F. Tortella, J. Moreton, N. Khazan, 1978, The Journal of pharmacology and experimental therapeutics.

A quantitative analysis of the shaking behavior induced in rats by beta-endorphin and [D-Ala2, Met5]enkephalinamide.

F. Tortella, A. Cowan, 1982, Life sciences.

Electroconvulsive shock results in a functional activation of endorphin systems.

J. Holaday, F. Tortella, G. Belenky, 1981, Modern problems of pharmacopsychiatry.

A selective role for delta-receptors in the regulation of opioid-induced changes in seizure threshold.

J. Holaday, F. Tortella, A. Cowan, 1983, Life sciences.

Dual Therapeutic Effects of C-10068, a Dextromethorphan Derivative, Against Post-Traumatic Nonconvulsive Seizures and Neuroinflammation in a Rat Model of Penetrating Ballistic-Like Brain Injury.

F. Tortella, Philip B. Graham, V. Uttamsingh, 2015, Journal of neurotrauma.

Dextromethorphan and neuromodulation: old drug coughs up new activities.

F. Tortella, N. Bowery, M. Pellicanò, 1989, Trends in pharmacological sciences.

Behavioral effects of non‐opioid antitussive anticonvulsants

F. Tortella, J. Witkin, Frank C. Tortella, 1989 .

Evaluation of Gabapentin and Ethosuximide for Treatment of Acute Nonconvulsive Seizures following Ischemic Brain Injury in Rats

F. Tortella, J. Hartings, J. Dave, 2006, Journal of Pharmacology and Experimental Therapeutics.

Clinical Utility of Serum Levels of Ubiquitin C-terminal Hydrolase as a Biomarker for Severe Traumatic Brain Injury

A. Gabrielli, F. Tortella, R. Hayes, 2022 .

Neuroproteomics: a biochemical means to discriminate the extent and modality of brain injury.

F. Tortella, R. Hayes, J. Dave, 2010, Journal of neurotrauma.

Extensive degradation of myelin basic protein isoforms by calpain following traumatic brain injury

F. Tortella, R. Hayes, J. Dave, 2006, Journal of neurochemistry.

Ability of Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase-L1, and S100B To Differentiate Normal and Abnormal Head Computed Tomography Findings in Patients with Suspected Mild or Moderate Traumatic Brain Injury

F. Tortella, R. Hayes, P. Barzó, 2016, Journal of neurotrauma.

Brain injury biomarkers may improve the predictive power of the IMPACT outcome calculator.

A. Gabrielli, F. Tortella, R. Hayes, 2012, Journal of neurotrauma.

Glial neuronal ratio: a novel index for differentiating injury type in patients with severe traumatic brain injury.

R. Bullock, F. Tortella, A. Jeromin, 2012, Journal of neurotrauma.

Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study

F. Tortella, R. Hayes, A. Buki, 2011, Critical care.

Serum-Based Phospho-Neurofilament-Heavy Protein as Theranostic Biomarker in Three Models of Traumatic Brain Injury: An Operation Brain Trauma Therapy Study.

P. Kochanek, F. Tortella, H. Bramlett, 2019, Journal of neurotrauma.

EEG seizure activity and behavioral neurotoxicity produced by (+)-MK801, but not the glycine site antagonist L-687,414, in the rat

F. Tortella, R. Hill, 1996, Neuropharmacology.

Suppressant effects of selective 5-HT2 antagonists on rapid eye movement sleep in rats

F. Tortella, B. Cox, T. Blackburn, 1989, Brain Research.

Multiple opiate receptors: functional implications.

J. Holaday, F. Tortella, J. Long, 1985, Federation proceedings.

RS-100642-198, a novel sodium channel blocker, provides differential neuroprotection against hypoxia/hypoglycemia, veratridine or glutamate-mediated neurotoxicity in primary cultures of rat cerebellar neurons

F. Tortella, J. Dave, H. Ved, 2001, Neurotoxicity Research.

EEG spectral analysis of the neuroprotective kappa opioids enadoline and PD117302.

F. Tortella, J. Hunter, J. Hughes, 1997, The Journal of pharmacology and experimental therapeutics.

U50,488, a highly selective kappa opioid: anticonvulsant profile in rats.

J. Holaday, F. Tortella, L. Robles, 1986, The Journal of pharmacology and experimental therapeutics.

Quantitative Real-Time RT—PCR Analysis of Inflammatory Gene Expression Associated with Ischemia—Reperfusion Brain Injury

F. Tortella, J. Moffett, P. Elliott, 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Human amnion-derived multipotent progenitor cell treatment alleviates traumatic brain injury-induced axonal degeneration.

F. Tortella, V. Marshall, J. Dave, 2009, Journal of neurotrauma.

Chronic administration of morphine and naltrexone up-regulate[3H][d-ala2,d-leu5]enkephalin binding sites by different mechanisms

J. Holaday, F. Tortella, J. Long, 1988, Neuropharmacology.

Differential antagonism of mu agonists by U50,488H in the rat.

F. Tortella, F. Porreca, 1987, Life sciences.

Neuroprotective role of c‐fos antisense oligonucleotide: in vitro and in vivo studies

F. Tortella, J. Dave, H. Ved, 1997, Neuroreport.

Synthesis and evaluation of 3-substituted 17-methylmorphinan analogs as potential anticonvulsant agents.

F. Tortella, N. Bowery, A. Newman, 1992, Journal of medicinal chemistry.

Down-regulation of the sodium channel Na(v)1.1 alpha-subunit following focal ischemic brain injury in rats: in situ hybridization and immunohistochemical analysis.

F. Tortella, J. Hartings, J. Dave, 2005, Life sciences.

Topiramate reduces non-convulsive seizures after focal brain ischemia in the rat

F. Tortella, J. Hartings, A. Williams, 2008, Neuroscience Letters.

The Challenge of Mild Traumatic Brain Injury: Role of Biochemical Markers in Diagnosis of Brain Damage

F. Tortella, A. Jeromin, R. Hayes, 2014, Medicinal research reviews.

Human Traumatic Brain Injury Induces Autoantibody Response against Glial Fibrillary Acidic Protein and Its Breakdown Products

F. Tortella, C. Robertson, J. Dave, 2014, PloS one.

A novel animal model of closed-head concussive-induced mild traumatic brain injury: development, implementation, and characterization.

Lai Yee Leung, F. Tortella, J. Dave, 2012, Journal of neurotrauma.

Biochemical Markers of Brain Injury: Applications to Combat Casualty Care

F. Tortella, R. Hayes, J. Dave, 2004 .

Accumulation of Calpain and Caspase-3 Proteolytic Fragments of Brain-Derived αII-Spectrin in Cerebral Spinal Fluid after Middle Cerebral Artery Occlusion in Rats

F. Tortella, B. Pike, R. Hayes, 2004, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Novel Differential Neuroproteomics Analysis of Traumatic Brain Injury in Rats*

F. Tortella, R. Hayes, J. Dave, 2006, Molecular & Cellular Proteomics.

Evidence for mu opioid receptor mediation of enkephalin-induced electroencephalographic seizures.

F. Tortella, H. Mosberg, L. Robles, 1987, The Journal of pharmacology and experimental therapeutics.

Occurrence of nonconvulsive seizures, periodic epileptiform discharges, and intermittent rhythmic delta activity in rat focal ischemia

F. Tortella, J. Hartings, Jed A Hartings, 2003, Experimental Neurology.

Proteasome inhibitor PS519 reduces infarction and attenuates leukocyte infiltration in a rat model of focal cerebral ischemia.

F. Tortella, P. Elliott, J. Phillips, 2000, Stroke.

Opioids: Epilepsy and Neuroprotection

F. Tortella, 1993 .

Spreading depolarizations and late secondary insults after traumatic brain injury.

F. Tortella, J. Hartings, A. Strong, 2009, Journal of neurotrauma.

F. Tortella, V. Khatri, X. Lu, 2013, Journal of neurotrauma.

NNZ-2566, a Glypromate Analog, Attenuates Brain Ischemia-Induced Non-Convulsive Seizures in Rats

F. Tortella, J. Hartings, Y. Si, 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Neuroprotection produced by the NAALADase inhibitor 2-PMPA in rat cerebellar neurons.

F. Tortella, J. Dave, H. Ved, 2000, European journal of pharmacology.

Electroencephalogram analysis and neuroprotective profile of the N-acetylated-alpha-linked acidic dipeptidase inhibitor, GPI5232, in normal and brain-injured rats.

F. Tortella, A. Williams, B. Slusher, 2001, The Journal of pharmacology and experimental therapeutics.

The anticonvulsant effects of dadle are primarily mediated by activation of δ opioid receptors: interactions between δ and μ receptor antagonists

J. Holaday, F. Tortella, L. Robles, 1985 .

Insight into Pre-Clinical Models of Traumatic Brain Injury Using Circulating Brain Damage Biomarkers: Operation Brain Trauma Therapy.

P. Kochanek, F. Tortella, H. Bramlett, 2016, Journal of neurotrauma.

Biomarkers track damage after graded injury severity in a rat model of penetrating brain injury.

F. Tortella, R. Hayes, J. Dave, 2013, Journal of neurotrauma.

Cognitive Evaluation Using Morris Water Maze in Neurotrauma.

F. Tortella, Krista L. Caudle, D. Shear, 2016, Methods in molecular biology.

The kappa opioid agonist U-50,488H antagonizes respiratory effects of mu opioid receptor agonists in conscious rats.

J. Holaday, F. Tortella, J. Long, 1993, The Journal of pharmacology and experimental therapeutics.

Highly selective σ1 ligands based on dextromethorphan

F. Tortella, A. Newman, S. Izenwasser, 1996 .

Tortella and Bowery reply

F. Tortella, Bowery G. Norman, 1990 .

N-Substituted-3-alkoxy-derivatives of dextromethorphan are functional NMDA receptor antagonists in vivo: Evidence from an NMDA-induced seizure model in rats

Jodi L. Smith, F. Tortella, A. Newman, 2021, Pharmacology, Biochemistry and Behavior.

PD117302, a selective non-peptide opioid kappa agonist, protects against NMDA and maximal electroshock convulsions in rats.

F. Tortella, J. C. Hunter, J. Hughes, 1990, Life sciences.

Selective kappa antagonist properties of nor-binaltorphimine in the rat MES seizure model.

J. Holaday, F. Tortella, A. Lipkowski, 1989, Life sciences.

Endogenous opioid peptides and epilepsy: quieting the seizing brain?

F. Tortella, F C Tortella, 1988, Trends in pharmacological sciences.

A comparison of the anticonvulsant effects of two systemically active enkephalin analogues in rats.

F. Tortella, M. Adler, A. Cowan, 1981, European journal of pharmacology.

Inflammatory Gene Response in Rat Brain Following Soman Exposure

F. Tortella, J. Dave, R. Berti, 2005 .

Central neuro-inflammatory gene response following soman exposure in the rat

F. Tortella, J. Dave, A. Williams, 2003, Neuroscience Letters.

Serum brain biomarker level, neurocognitive performance, and self-reported symptom changes in soldiers repeatedly exposed to low-level blast: a breacher pilot study.

Stephanie E. Eonta, Yang Zhang, F. Tortella, 2013, Journal of neurotrauma.

Intrathecal CGX-1007 is neuroprotective in a rat model of focal cerebral ischemia

F. Tortella, R. Mccabe, A. Williams, 2002, Neuroreport.

A comparison of two cognitive test paradigms in a penetrating brain injury model

F. Tortella, X. Lu, D. Shear, 2010, Journal of Neuroscience Methods.

Neuroprotective sigma ligands attenuate NMDA and trans-ACPD-induced calcium signaling in rat primary neurons

F. Tortella, K. Klette, M. DeCoster, 1997, Brain Research.

Antiepileptic Drug Treatment of Nonconvulsive Seizures Induced by Experimental Focal Brain Ischemia

F. Tortella, J. Hartings, A. Williams, 2004, Journal of Pharmacology and Experimental Therapeutics.

Evaluation of neuroprotection and behavioral recovery by the kappa-opioid, PD117302 following transient forebrain ischemia

F. Tortella, J. Moreton, R. Genovese, 1994, Brain Research Bulletin.

Seizures and Cognitive Outcome After Traumatic Brain Injury: A Post Hoc Analysis

J. Kramer, F. Tortella, J. Hartings, 2021, Neurocritical Care.

Subacute Low Dose Nerve Agent Exposure Causes DNA Fragmentation in Guinea Pig Leukocytes

F. Tortella, J. Moffett, J. Dave, 2005 .

Neuroprotective profile of dextromethorphan in an experimental model of penetrating ballistic-like brain injury

F. Tortella, X. Lu, D. Shear, 2009, Pharmacology Biochemistry and Behavior.

Eeg and behavioral effects of ethylketocyclazocine, morphine and cyclazocine in rats: Differential sensitivities towards naloxone

F. Tortella, M. Adler, A. Cowan, 1980, Neuropharmacology.

A multifunctional cytoprotective agent that reduces neurodegeneration after ischemia

F. Tortella, R. Brady, H. Ghanbari, 2006, Proceedings of the National Academy of Sciences of the United States of America.

ICI 154,129, a δ-opioid receptor antagonist raises seizure threshold in rats

J. Holaday, F. Tortella, A. Cowan, 1984 .

Mechanism of Action for NNZ-2566 Anti-inflammatory Effects Following PBBI Involves Upregulation of Immunomodulator ATF3

F. Tortella, J. Dave, Kara E. Schmid, 2013, NeuroMolecular Medicine.

Severity profile of penetrating ballistic-like brain injury on neurofunctional outcome, blood-brain barrier permeability, and brain edema formation.

F. Tortella, J. Dave, X. Lu, 2011, Journal of neurotrauma.

Longitudinal characterization of motor and cognitive deficits in a model of penetrating ballistic-like brain injury.

F. Tortella, X. Lu, D. Shear, 2010, Journal of neurotrauma.

NNZ-2566, a glypromate analog, improves functional recovery and attenuates apoptosis and inflammation in a rat model of penetrating ballistic-type brain injury.

F. Tortella, J. Dave, X. Lu, 2009, Journal of neurotrauma.

Characterization of a new rat model of penetrating ballistic brain injury.

F. Tortella, J. Hartings, J. Dave, 2005, Journal of neurotrauma.

In vivo interactions among opiate receptor agonists and antagonists.

J. Holaday, F. Tortella, J. Long, 1986, NIDA research monograph.

Abstract 13492: Glial Fibrillary Acidic Protein, a Sensitive and Specific Marker in Serum for the Identification of Intracerebral Hemorrhage in Acute Stroke Patients: Results of Improved Assay Performance

A. Gabrielli, F. Tortella, A. Jeromin, 2011 .

Operation Brain Trauma Therapy: 2016 Update.

P. Kochanek, F. Tortella, H. Bramlett, 2018, Military medicine.

Anticonvulsant effects of mu (DAGO) and delta (DPDPE) enkephalins in rats

J. Holaday, F. Tortella, H. Mosberg, 1988, Peptides.

Electroencephalographic assessment of the role of δ receptors in opioid peptide - induced seizures

J. Holaday, F. Tortella, H. Mosberg, 1984, Neuropeptides.

Electroencephalographic assessment of the role of delta receptors in opioid peptide - induced seizures.

J. Holaday, F. Tortella, H. Mosberg, 1984, Neuropeptides.

Decline in arylsulfatase B and Increase in chondroitin 4‐sulfotransferase combine to increase chondroitin 4‐sulfate in traumatic brain injury

S. Bhattacharyya, J. Tobacman, F. Tortella, 2015, Journal of neurochemistry.

The Revised Neurobehavioral Severity Scale (NSS-R) for Rodents.

Erin S. Barry, F. Tortella, A. Yarnell, 2016, Current protocols in neuroscience.

Functional and Molecular Correlates after Single and Repeated Rat Closed-Head Concussion: Indices of Vulnerability after Brain Injury.

F. Tortella, A. Yarnell, D. Shear, 2017, Journal of neurotrauma.

Effect of the proteasome inhibitor MLN519 on the expression of inflammatory molecules following middle cerebral artery occlusion and reperfusion in the rat

F. Tortella, J. Moffett, P. Elliott, 2009, Neurotoxicity Research.

The WRAIR Projectile Concussive Impact Model of Mild Traumatic Brain Injury: Re-design, Testing and Preclinical Validation

F. Tortella, Kara E. Schmid, D. Shear, 2014, Annals of Biomedical Engineering.

A Military-Relevant Model of Closed Concussive Head Injury: Longitudinal Studies Characterizing and Validating Single and Repetitive mTBI

F. Tortella, X. Lu, Jenny R. Browning, 2013 .

Modeling cerebral ischemia in neuroproteomics.

F. Tortella, J. Dave, X. Lu, 2009, Methods in molecular biology.

Amelioration of Penetrating Ballistic-Like Brain Injury Induced Cognitive Deficits after Neuronal Differentiation of Transplanted Human Neural Stem Cells.

R. Bullock, F. Tortella, M. Hefferan, 2017, Journal of neurotrauma.

Effects of delayed intrathecal infusion of an NMDA receptor antagonist on ischemic injury and peri-infarct depolarizations

F. Tortella, J. Hartings, X. Lu, 2005, Brain Research.

Continuous Electroencephalography After Moderate to Severe Traumatic Brain Injury

F. Tortella, J. Hartings, M. Privitera, 2019, Critical care medicine.

PAN-811 (3-Aminopyridine-2-carboxaldehyde thiosemicarbazone), a novel neuroprotectant, elicits its function in primary neuronal cultures by up-regulating Bcl-2 expression

F. Tortella, H. Ghanbari, J. Dave, 2005, Neuroscience.

Novel anticonvulsant analogs of dextromethorphan: improved efficacy, potency, duration and side-effect profile.

F. Tortella, A. Newman, J. Witkin, 1994, The Journal of pharmacology and experimental therapeutics.

Modulators of N-methyl-D-aspartate protect against diazepam- or phenobarbital-resistant cocaine convulsions.

F. Tortella, J. Witkin, Jeffrey M. Witkin, 1991, Life sciences.

Pupillary effects of leucine and methionine enkephalin in rats after intraperitoneal administration

F. Tortella, M. Adler, A. Cowan, 1980, Peptides.

Neuroprotective effects of the sodium channel blocker RS100642 and attenuation of ischemia-induced brain seizures in the rat

F. Tortella, Anthony J Williams, Frank C Tortella, 2002, Brain Research.

Neuroprotection of Selective Brain Cooling After Penetrating Ballistic-like Brain Injury in Rats.

F. Tortella, X. Lu, D. Shear, 2011, Therapeutic hypothermia and temperature management.

Recovery from ischemic brain injury in the rat following a 10 h delayed injection with MLN519

F. Tortella, T. Myers, X. Lu, 2005, Pharmacology Biochemistry and Behavior.

Neuroprotection assessment by topographic electroencephalographic analysis: effects of a sodium channel blocker to reduce polymorphic delta activity following ischaemic brain injury in rats

F. Tortella, J. Hartings, Jed A Hartings, 2003, Fundamental & clinical pharmacology.

Delayed Treatment with MLN519 Reduces Infarction and Associated Neurologic Deficit Caused by Focal Ischemic Brain Injury in Rats via Antiinflammatory Mechanisms Involving Nuclear Factor-κB Activation, Gliosis, and Leukocyte Infiltration

F. Tortella, J. Moffett, P. Elliott, 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies.

F. Tortella, J. Dave, J. Phillips, 2000, The Journal of pharmacology and experimental therapeutics.

Combined hypoxemic and hypotensive insults altered physiological responses and neurofunction in a severity-dependent manner following penetrating ballistic-like brain injury in rats

F. Tortella, D. Shear, Ying Deng-Bryant, 2015, The journal of trauma and acute care surgery.

DNA fragmentation in leukocytes following subacute lowdose nerve agent exposure

F. Tortella, J. Moffett, J. Dave, 2003, Cellular and Molecular Life Sciences CMLS.

Mechanism of Action for NNZ-2566 Anti-inflammatory Effects Following PBBI Involves Upregulation of Immunomodulator ATF3

F. Tortella, J. Dave, Kara E. Schmid, 2013, NeuroMolecular Medicine.

Studies on neuronal apoptoisis in primary forebrain cultures: Neuroprotective/anti-apoptotic action of NR2B NMDA antagonists

F. Tortella, J. Moffett, J. Dave, 2009, Neurotoxicity Research.

Glucose and oxygen metabolism after penetrating ballistic-like brain injury

F. Tortella, Weizhao Zhao, M. Bullock, 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Kappa opioids: therapeutic considerations in epilepsy and CNS injury.

F. Tortella, M. DeCoster, 1994, Clinical neuropharmacology.

Microarray analysis of acute and delayed gene expression profile in rats after focal ischemic brain injury and reperfusion

F. Tortella, J. Hartings, J. Dave, 2004, Journal of neuroscience research.

Military Blast Exposure and Chronic Neurodegeneration: Summary of Working Groups and Expert Panel Findings and Recommendations

Tyler F. Rooks, Laurel J. Ng, Daniel C. Krawczyk, 2017 .

Novel 1-phenylcycloalkanecarboxylic acid derivatives as potential anticonvulsant agents.

F. Tortella, A. Newman, S. Calderon, 1991, Journal of medicinal chemistry.

Tolerance develops to spinal morphine analgesia but not morphine-induced convulsions.

F. Tortella, B. Yoburn, V. Sierra, 1990, European journal of pharmacology.

NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats

F. Tortella, J. Dave, X. Lu, 2009, Journal of Neuroinflammation.